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NAKAMURA Hiroyuki  中村 浩幸

ORCIDConnect your ORCID iD *help
Researcher Number 70256866
Affiliation (Current) 2025: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 室長
Affiliation (based on the past Project Information) *help 2023: 国立研究開発法人国立成育医療研究センター, 母児感染研究室, 室長
2016 – 2023: 国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 室長
2017: 国立成育医療研究センター, 母児感染研究室長
2014: 独立行政法人国立成育医療研究センター, その他部局等, 室長
2012 – 2013: 独立行政法人国立成育医療研究センター, 母児感染研究部, 室長
2005: National Center for Child Health and Development, Department of Infectious Diseases, Laboratory Head, 母児感染研究部, 室長
2004: 国立成育医療センター研究所, 母児感染研究部, 室長
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Embryonic/Neonatal medicine / Virology
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Otorhinolaryngology / Pediatrics
Keywords
Principal Investigator
難聴 / サイトメガロウイルス / 先天性サイトメガロウイルス感染症 / 母子感染 / CMV / 神経障害 / shRNA / 神経学的合併症 / 先天性CMV感染症 / p53 … More / vIRF1 / KSHV / HHV-8 / 先天感染症 / iPS細胞 / 母児感染 / ウイルス生活環 / 相互作用 / 低分子ヘアピン型RNA / 日和見感染症 / HCMV / ヒトサイトメガロウイルス / ゲノムワイドスクリーニング / 精神発達遅滞 / 感音性難聴 / 神経 / 感覚器障害 / 細胞障害 / 神経学的障害 / IE2 / SLITRK6 / interferon / ATM / インターフェロン / ヒトヘルペスウイルス8型 / 母子感染症 / 人工多能性幹細胞 / アポトーシス / 先天性感染症 … More
Except Principal Investigator
ウイルス感染 / CMV感染症 / ミニ腸 / 腸管オルガノイド / ヒトサイトメガロウイルス (CMV) / 生殖・泌尿器疾患 / 泌尿器官 / 生殖器官 / 感染症 / 神経系疾患 / 泌尿器系疾患 / 生殖器系疾患 / 細胞外微粒子 / 神経疾患 / 共生細菌叢 / 神経細胞 / 生殖・泌尿器官 / ウイルス感染制御 / テトラスパニン / CD9 / エクソソーム / マイクロエクソソーム / 母胎感染 / ウイルス胎盤感染 / PCR / 進行性難聴 / 先天性ウイルス感染 / 母胎胎内感染 / 臍帯 / 乾燥臍帯 / RNAウイルス / 先天性風疹症候群 / 遅発性難聴 / 胎盤感染 / 神経幹・前駆細胞 / ヒトサイトメガロウイルス / 難聴 / SLITRK6 / CMV / サイトメガロウイルス / 先天性サイトメガロウイルス感染症 Less
  • Research Projects

    (9 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (17 People)
  •  ミニ腸による日和見CMV腸炎制御へ向けた感染予測・制御機序の研究

    • Principal Investigator
      内田 孟
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      National Center for Child Health and Development
  •  先天性サイトメガロウイルス感染による神経学的合併症の分子病態解明とその制御法開発Principal Investigator

    • Principal Investigator
      中村 浩幸
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Center for Child Health and Development
  •  Childbirth versus infectious diseases: Molecular linkage between receptivity and insusceptibility

    • Principal Investigator
      Miyado Kenji
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      National Center for Child Health and Development
  •  Exploration of cellular factors involved in CMV neuropathogenesis in congenital CMV infectionPrincipal Investigator

    • Principal Investigator
      Nakamura Hiroyuki
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      National Center for Child Health and Development
  •  Analysis on the role of SLITRK6 in congenital CMV infection

    • Principal Investigator
      Fujiwara Shigeyoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      National Center for Child Health and Development
  •  Mechanism of neurodevelopmental disabilities caused by congenital cytomegalovirus infectionPrincipal Investigator

    • Principal Investigator
      Nakamura Hiroyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      National Center for Child Health and Development
  •  Relation of viral infection during pregnancy to hearing-impaired children

    • Principal Investigator
      Morimoto Noriko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      National Center for Child Health and Development
  •  Establishment of experimental models for the study of congenital cytomegalovirus infectionPrincipal Investigator

    • Principal Investigator
      NAKAMURA Hiroyuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      National Research Institute for Child Health and Development
  •  Molecular mechanism of repressing IFN-mediated activity by viral interferon regulatory factor.Principal Investigator

    • Principal Investigator
      NAKAMURA Hiroyuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      National Center for Child Health and Development

All 2022 2021 2020 2019 2018 2017 2016 2014 2013 2012 2006 2005 2004

All Journal Article Presentation Patent

  • [Journal Article] Rubella Virus Triggers Type I Interferon Antiviral Response in Cultured Human Neural Cells: Involvement in the Control of Viral Gene Expression and Infectious Progeny Production.2022

    • Author(s)
      Sakuragi S, Liao H, Yajima K, Fujiwara S, Nakamura H.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 17 Pages: 9799-9799

    • DOI

      10.3390/ijms23179799

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07901, KAKENHI-PROJECT-19H01067
  • [Journal Article] Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis2020

    • Author(s)
      Fujiwara Shigeyoshi、Nakamura Hiroyuki
    • Journal Title

      Pathogens

      Volume: 9 Issue: 2 Pages: 116-116

    • DOI

      10.3390/pathogens9020116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10068, KAKENHI-PROJECT-19K08335
  • [Journal Article] Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction2020

    • Author(s)
      Kang Woojin、Harada Yuichirou、Yamatoya Kenji、Kawano Natsuko、Kanai Seiya、Miyamoto Yoshitaka、Nakamura Akihiro、Miyado Mami、Hayashi Yoshiki、Kuroki Yoko、Saito Hidekazu、Iwao Yasuhiro、Umezawa Akihiro、Miyado Kenji
    • Journal Title

      Laboratory Investigation

      Volume: 100 Issue: 4 Pages: 583-595

    • DOI

      10.1038/s41374-019-0353-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06474, KAKENHI-PROJECT-19K09793, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-18H03556, KAKENHI-PROJECT-18K06240
  • [Journal Article] Suppression of Non-Random Fertilization by MHC Class I Antigens2020

    • Author(s)
      Kamiya Junki、Kang Woojin、Yoshida Keiichi、Takagi Ryota、Kanai Seiya、Hanai Maito、Nakamura Akihiro、Yamada Mitsutoshi、Miyamoto Yoshitaka、Miyado Mami、Kuroki Yoko、Hayashi Yoshiki、Umezawa Akihiro、Kawano Natsuko、Miyado Kenji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 22 Pages: 8731-8731

    • DOI

      10.3390/ijms21228731

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06240, KAKENHI-PROJECT-19K06474, KAKENHI-PROJECT-19K09682, KAKENHI-PROJECT-19K09793, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-18H03556, KAKENHI-PROJECT-17K16850, KAKENHI-PROJECT-23K20330
  • [Journal Article] Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality.2020

    • Author(s)
      Yamada M, Sato S, Ooka R, Akashi K, Nakamura A, Miyado K, Akutsu H, Tanaka M.
    • Journal Title

      Reprod Med Biol.

      Volume: 3:20(1) Issue: 1 Pages: 53-61

    • DOI

      10.1002/rmb2.12356

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09787, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-20H00550
  • [Journal Article] Chronic Active Epstein?Barr Virus Infection: Is It Immunodeficiency, Malignancy, or Both?2020

    • Author(s)
      Fujiwara Shigeyoshi、Nakamura Hiroyuki
    • Journal Title

      Cancers

      Volume: 12 Issue: 11 Pages: 3202-3202

    • DOI

      10.3390/cancers12113202

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08335
  • [Journal Article] Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.2019

    • Author(s)
      Ogawa S, Yamada M, Nakamura A, Sugawara T, Nakamura A, Miyajima S, Harada Y, Ooka R, Okawa R, Miyauchi J, Tsumura H, Yoshimura Y, Miyado K, Akutsu H, Tanaka M, Umezawa A, Hamatani T.
    • Journal Title

      Stem Cell Reports

      Volume: 12 Issue: 6 Pages: 1366-1379

    • DOI

      10.1016/j.stemcr.2019.05.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08666, KAKENHI-PROJECT-19K22602, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-16H05475, KAKENHI-PROJECT-17H04236, KAKENHI-PROJECT-17H05100
  • [Journal Article] Calaxin is required for cilia-driven determination of vertebrate laterality2019

    • Author(s)
      Sasaki Keita、Shiba Kogiku、Nakamura Akihiro、Kawano Natsuko、Satouh Yuhkoh、Yamaguchi Hiroshi、Morikawa Motohiro、Shibata Daisuke、Yanase Ryuji、Jokura Kei、Nomura Mami、Miyado Mami、Takada Shuji、Ueno Hironori、Nonaka Shigenori、Baba Tadashi、Ikawa Masahito、Kikkawa Masahide、Miyado Kenji、Inaba Kazuo
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 226-226

    • DOI

      10.1038/s42003-019-0462-y

    • NAID

      120006957456

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07425, KAKENHI-PROJECT-18K06241, KAKENHI-PROJECT-19K06474, KAKENHI-PROJECT-19K06592, KAKENHI-PROJECT-19K09682, KAKENHI-PROJECT-17H01440, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-17K16313, KAKENHI-PROJECT-16H02502
  • [Journal Article] Human cytomegalovirus downregulates SLITRK6 expression through IE2.2017

    • Author(s)
      Liao H, Sato H, Chiba R, Kawai T, Nakabayashi K, Hata K, Akutsu H, Fujiwara S, Nakamura H.
    • Journal Title

      Journal of Neurovirology

      Volume: 23 Issue: 1 Pages: 79-86

    • DOI

      10.1007/s13365-016-0475-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K10118
  • [Journal Article] The highly conserved human cytomegalovirus UL136 ORF generates multiple Golgi-localizing protein isoforms through differential translation initiation2014

    • Author(s)
      Liao H, Lee JH, Kondo R, Katata M, Imadome K, Miyado K, Inoue N, Fujiwara S, Nakamura H
    • Journal Title

      Virus Res

      Volume: 179 Pages: 241-6

    • DOI

      10.1016/j.virusres.2013.11.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-24591616, KAKENHI-PROJECT-25460578
  • [Journal Article] Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress2013

    • Author(s)
      Nakamura H, Imadome K, et al.(他10名)
    • Journal Title

      Herpesviridae

      Volume: 4(1) Issue: 1 Pages: 2-2

    • DOI

      10.1186/2042-4280-4-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591375, KAKENHI-PROJECT-24591616, KAKENHI-PROJECT-25460578
  • [Journal Article] Pathogenesis by gammaherpesviruses.2006

    • Author(s)
      Nakamura H, Fujiwara S.
    • Journal Title

      Nippon Rinsho 64 (Suppl.3)

      Pages: 580-583

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590397
  • [Journal Article] γヘルペスウイルスの病原性発現機構2006

    • Author(s)
      中村 浩幸
    • Journal Title

      日本臨床増刊 ヘルペスウイルス学-基礎・臨床研究の進歩- 64巻増刊号3

      Pages: 580-583

    • Data Source
      KAKENHI-PROJECT-16590397
  • [Journal Article] Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.2006

    • Author(s)
      Shin YC, Nakamura H, Liang X, Feng P, Chang H, Kowalik TF, Jung JU.
    • Journal Title

      J.Virol. 80

      Pages: 2257-2266

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590397
  • [Journal Article] γヘルペスウイルスの病原性発現機構2006

    • Author(s)
      中村浩幸
    • Journal Title

      日本臨床増刊 ヘルペスウイルス学 -基礎・臨床研究の進歩- 64巻増刊号3

      Pages: 580-583

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590397
  • [Journal Article] Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival.2005

    • Author(s)
      Imadome K, Shimizu N, Arai A, Miura O, Watanabe K, Nakamura H, Nonoyama S, Yamamoto K, Fujiwara S.
    • Journal Title

      J.Infect.Dis. 192

      Pages: 1340-1348

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590397
  • [Journal Article] Kaposi's sarcoma-associated herpesvirus K7 protein targets a ubiquitin-like/ubiquitin-associated domain-containing protein to promote protein degradation.2004

    • Author(s)
      Feng P, Scott CW, Che NH, Nakamura H, Chung YH, Monteiro MJ, Jung JU.
    • Journal Title

      Moll.Cell.Biol. 24

      Pages: 3938-3948

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590397
  • [Patent] サイトメガロウイルス関連疾患の予防又は治療用の剤2020

    • Inventor(s)
      中村浩幸、渡邉拓実、藤原成悦
    • Industrial Property Rights Holder
      国立開発法人国立成育医療研究センター
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19K08335
  • [Patent] サイトメガロウイルス関連疾患の予防又は治療用の剤2019

    • Inventor(s)
      中村浩幸、渡邉拓実、藤原成悦
    • Industrial Property Rights Holder
      国立研究開発法人国立成育医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-213781
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19K08335
  • [Presentation] A Combined Systematic and Targeted Literature Review of the Burden of Cytomegalovirus and Congenital Cytomegalovirus Infection in Japan.2022

    • Author(s)
      Hosoya S, Nakamura H, Umezawa A, Kawai K, Myers E, Mucha J, Neumann M, Lewandowski W, Kaczanowska M, Schmidt E, Natenshon A, Talarico C, Buck PO, Diaz-Decaro J.
    • Organizer
      The 10th Asian Congress of Pediatric Infectious Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K07901
  • [Presentation] ヒト神経系細胞におけるCMV感染と細胞外小胞との関連について2021

    • Author(s)
      矢島広大、安藤由梨花、櫻木小百合、藤原成悦、康宇鎭、宮戸健二、河野菜摘子、中村浩幸
    • Organizer
      第34回ヘルペスウイルス研究会
    • Data Source
      KAKENHI-PROJECT-19K08335
  • [Presentation] 大脳層構造形成におけるカルシウムセンサーEFCAB1の必須な役割2019

    • Author(s)
      中村彰宏、宮戸健二、山田満稔、田中守
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H01067
  • [Presentation] ヒトサイトメガロウイルスはIE2を介して難聴原因遺伝子SLITRK6の発現を抑制する2018

    • Author(s)
      廖 華南、渡邉拓実、藤原成悦、中村浩幸
    • Organizer
      第32回ヘルペスウイルス研究会
    • Data Source
      KAKENHI-PROJECT-16K10118
  • [Presentation] ヒトサイトメガロウイルスはIE2を介して難聴原因遺伝子SLITRK6の発現を抑制する2018

    • Author(s)
      廖華南、渡邉拓実、藤原成悦、中村浩幸
    • Organizer
      第32回ヘルペスウイルス研究会
    • Data Source
      KAKENHI-PROJECT-17K10068
  • [Presentation] Innate immune response to Rubella virus infection in human neural cells2018

    • Author(s)
      Huanan Liao, Takumi, Watanabe, Shigeyoshi Fujiwara, Nakamura Hiroyuki
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10118
  • [Presentation] Innate immune response to Rubella virus infection in human neural cells2018

    • Author(s)
      Liao H, Watanabe T, Fujiwara S, Nakamura H
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10068
  • [Presentation] Human cytomegalovirus infection downregulates the expression of SLITRK6, one of causative genes for hereditary sensorineural hearing loss.2016

    • Author(s)
      Hiroyuki Nakamura, Huanan Liao, Shigeyoshi Fujiwara.
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-16K10118
  • [Presentation] サイトメガロウイルスによる神経幹・前駆細胞障害機構の解析2013

    • Author(s)
      廖 華南、近藤力太、堅田真礼、南 佳ほり、阿久津英憲、梅澤明弘、井上直樹、藤原成悦、中村浩幸
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24591616
  • [Presentation] ヒト人工多能性幹細胞を用いた神経幹細胞への実験的HCMV感染系の確立2012

    • Author(s)
      中村浩幸、廖 華南、南 佳ほり、阿久津英憲、梅澤明弘、井上直樹、藤原成悦
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-24591616
  • 1.  Fujiwara Shigeyoshi (30173488)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 2.  Morimoto Noriko (40286555)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Miyado Kenji (60324844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  宮入 烈 (10296626)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  齋藤 昭彦 (30531389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  河野 菜摘子 (00451691)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  山田 満稔 (40383864)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  浜谷 敏生 (60265882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  内田 孟 (30648697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  阿久津 英憲 (50347225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 11.  IZUMITA Ryouhei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  EDAYOSHI Mina
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HAYASHI Yoshiki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  SUGAWARA Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  IMADOME Kenichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 16.  NONAKA Shigenori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  井上 直和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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