Ohtani Hisakazu 大谷壽一

… Alternative Names

OHTANI Hisakazu 大谷壽一

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Researcher Number	70262029
Other IDs
External Links
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授 2025: 慶應義塾大学, 薬学部(芝共立), 教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 慶應義塾大学, 薬学部(芝共立), 教授 2012 – 2015: 慶應義塾大学, 薬学部, 教授 2009: 慶應義塾大学, 薬学部, 教授 2006 – 2008: The University of Tokyo, 大学院・薬学系研究科, 准教授 2006: 東京大学, 大学院薬学系研究科, 助教授 … More 2006: THE UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF PHARMACEUTICAL SCIENCES, VICE PROFESSOR, 大学院薬学系研究科, 寄付講座教員(客員助教授) 2005: 東京大学, 大学院・薬学系研究科, 寄付講座教員(客員助教授) 2005: 東京大学, 大学院薬学系研究科, 客員助教授 2004: 九州大学, 大学院・薬学研究院, 助教授 2000: Graduate Sch.of Pharm.Sci., KYUSHU UNIVERSITY Ass.Prof., 薬学研究院, 助教授 1999: 東大, 医学部附属病院, 助手 1998: Fac.of Med.Univ.of Tokyo, assistant, 医学部・附属病院, 助手 1997: 東京大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Applied pharmacology / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related / Medical sociology Except Principal Investigator Medical pharmacy / Medical sociology / 応用薬理学・医療系薬学 / Eating habits, studies on eating habits / Intelligent informatics
Keywords	Principal Investigator 遺伝子多型 / 薬物相互作用 / トランスポータ / 代謝酵素 / 飲食物 / 代謝阻害 / 個人差 / 個別化医療 / CYP2C / ジャバラ … More / 果汁 / OATPs / シトクロムP450 / グレープフルーツ / 飲食物成分 / トランスポーター / cytochrome P450 / 遺伝子多形 / 薬物トランスポータ / 薬物代謝酵素 / rats / microdialysis / 5-HT / fever / Veratrine / Clomipramine / antidepressant / Syndrome maline / 発熱反応 / ラット / マイクロダイアリシス / セロトニン / 発熱 / ベラトリン / クロミプラミン / 抗うつ薬 / 悪性症候群 / テーラーメード薬物治療 / テーラーメイド薬物治療 / 不可逆的阻害 / テーラーメード医療 / 医療ミス / データベース / 医薬品適正使用 / 剤形 / 包装 / トロホブラスト細胞 / 薬物輸送担体 / 血液胎盤関門 / 胎児毒性 / 胎児移行 / 胎盤 … More Except Principal Investigator Glial-Derived Neurotrophic Factor / 医薬品情報 / 投薬ミス / DRUG INFORMATION / DRUG EVOLUTION / PROPER USE OF DRUG / DRUG INTERACTIONS / COMPUTER-AIDED SYSTEM / DOSAGE OPTIMIZATION / PERSONALIZED MEDICATION / 医療品情報 / 育薬 / 医薬品適正使用 / 薬物相互作用 / 電子カルテ / 処方設計支援 / テーラーメード医療 / Blood-brain barrier / Brain capillary endothelial cells / Parkinson' disease / HVJ-liposomes / Gene Therapy / 遺伝子の発現 / in vivo / in vitro / 血液脳関門 / 脳毛細血管内皮細胞 / パーキンソン病 / 膜融合リポソーム / 遺伝子治療 / アクシデント・インシデント事例 / 事故疫学 / リスクマネジメント / 情報交換ネットワーク / リスクコミュニケーション / 有害事象情報 / 有用性情報 / 健康食品 / 薬物輸送担体 / 胎盤 / 薬物胎児移行 / 非ステロイド性消炎鎮痛剤 / 胎児毒性 / 生体分子 / 薬剤反応性 / 薬物動態学 / インタビューフォーム / 医療用添付文書 / 格付け / レーティング / ジェネリック / 後発医薬品 / 類似性指標 / 医薬品名類似度 / 処方関連度 / 医薬品情報学 Less

Analysis of the inter-individual variations of food-drug interactions via CYP2Cs and OATPsPrincipal Investigator
- Principal Investigator
  
  Ohtani Hisakazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactionsPrincipal Investigator
- Principal Investigator
  
  Hisakazu OHTANI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450Principal Investigator
- Principal Investigator
  
  OHTANI Hisakazu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Keio University
健康食品の安心・安全確保のための全国ネットワークの構築とその実証に関する研究
- Principal Investigator
  
  堀里子
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  The University of Tokyo
投薬ミス事例ライブラリーに基づく「事故疫学」確立と事前予測法の開発
- Principal Investigator
  
  澤田康文
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  The University of Tokyo
Development of system to predict fetal toxicity based on PK/PD evaluation by transplacental transfer and effect of drugs
- Principal Investigator
  
  SAWADA Yasufumi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
医療ミス防止をめざした医薬品の製剤・包装関連情報の規格化と有効利用法の確立Principal Investigator
- Principal Investigator
  
  大谷壽一
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  The University of Tokyo
医薬品情報学及び薬剤学に基づいたジェネリック医薬品の評価・格付け法の開発と評価
- Principal Investigator
  
  澤田康文
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical sociology
- Research Institution
  The University of Tokyo
医薬品の商標名類似度と処方関連度に基づく投薬ミス防止システム
- Principal Investigator
  
  竹田正幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Intelligent informatics
- Research Institution
  Kyushu University
薬物の経胎盤胎児移行における薬物輸送担体の機能的役割に関する研究Principal Investigator
- Principal Investigator
  
  大谷壽一
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokyo
  Kyushu University
DEVELOPMENT OF COMPUTER-AIDED PRESCRIPTION SYSTEM FOR PERSONALIZED PHARMACOTHERAPY BASED ON THE PHAEMACOKINETICS AND PHARMACODYNAMICS
- Principal Investigator
  
  SAWADA Yasufumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
薬剤の催不整脈性に対するリスクファクターとしての性差の解析Principal Investigator
- Principal Investigator
  
  大谷壽一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo
Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.
- Principal Investigator
  
  KOYABU Noriko, 松尾浩民
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  KYUSHU UNIVERSITY
Analysis of the relationship between antidepressant-induced Syndrome maline and Pharmaco KineticPrincipal Investigator
- Principal Investigator
  
  OHTANI Hisakazu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2009 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Comparison of the inhibitory effects of azole antifungals on cytochrome P450 3A4 genetic variants2021
- Author(s)
  Yamaguchi Yuki、Akiyoshi Takeshi、Kawamura Go、Imaoka Ayuko、Miyazaki Mitsue、Guengerich F. Peter、Nakamura Katsunori、Yamamoto Koujirou、Ohtani Hisakazu
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 38 Pages: 100384-100384
- DOI
  10.1016/j.dmpk.2021.100384
- NAID
  210000170640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06758
[Journal Article] The citrus fruit-derived flavanone glycoside narirutin is a novel potent inhibitor of organic anion-transporting polypeptides2020
- Author(s)
  Morita T, Akiyoshi T, Sato R, Uekusa Y, Katayama K, Yajima K, Imaoka A, Sugimoto Y, Kiuchi F, Ohtani H.
- Journal Title
  
  J Agric Food Chem
  
  Volume: 68 Issue: 48 Pages: 14182-14191
- DOI
  10.1021/acs.jafc.0c06132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-18K07302
[Journal Article] Profile of the inhibitory effects of gefitinib on CYP2D6 variants in vitro2020
- Author(s)
  Semba Yurika、Akiyoshi Takeshi、Hibino Hideyuki、Imaoka Ayuko、Ohtani Hisakazu
- Journal Title
  
  Int. Journal of Clinical Pharmacology and Therapeutics
  
  Volume: 58 Issue: 10 Pages: 539-542
- DOI
  10.5414/cp203698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06758
[Journal Article] pH-dependent transport kinetics of the human organic anion-transporting polypeptide 1A22019
- Author(s)
  T. Morita, T Akiyoshi, R. Sato, K. Katayama, K. Yajima, H. Kataoka, A. Imaoka, Y. Sugimoto, H. Ohtani
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 2 Pages: 220-227
- DOI
  10.1016/j.dmpk.2019.12.002
- NAID
  50014558590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K07302
[Journal Article] Inhibitory kinetics of fruit components on CYP2C19 activity.2019
- Author(s)
  H. Seki, T. Akiyoshi, A. Imaoka, H. Ohtani
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 34 Issue: 3 Pages: 181-186
- DOI
  10.1016/j.dmpk.2019.02.002
- NAID
  50014542460
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06758
[Journal Article] Inactivation kinetics and residual activity of CYP3A4 after treatment with erythromycin2017
- Author(s)
  Ishikawa Yuko、Akiyoshi Takeshi、Imaoka Ayuko、Ohtani Hisakazu
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 38 Issue: 7 Pages: 420-425
- DOI
  10.1002/bdd.2078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08596
[Journal Article] Variation in the inhibitory potency of terbinafine among genetic variants of CYP2D62015
- Author(s)
  Takeshi Akiyoshi, Miho Ishiuchi, Ayuko Imaoka, and Hisakazu Ohtani
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: in press
- NAID
  50014429969
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.2013
- Author(s)
  114. T. Akiyoshi, M. Ito, S. Murase, M. Miyazaki, F.P. Guengerich, K. Nakamura, K. Yamamoto, H. Ohtani
- Journal Title
  
  Drug Metabol. Pharmacokinet
  
  Volume: 25(5) Pages: 411-415
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants2013
- Author(s)
  Takeshi Akiyoshi, Marie Ito, Saori Murase, Mitsue Miyazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto and Hisakazu Ohtani
- Journal Title
  
  Drug Metabol Pharmacokinet
  
  Volume: 28
- NAID
  130004933542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590668
[Journal Article] 患者の健康食品使用に関する薬剤師の行動実態調査2009
- Author(s)
  朝比奈泰子、堀里子、大谷壽一、澤田康文
- Journal Title
  
  医療薬学 35(10)
  
  Pages: 685-92
- NAID
  130004502496
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650124
[Journal Article] 医療従事者を対象として定期的に健康食品情報を提供するインターネット研修システムの構築とその評価2009
- Author(s)
  朝比奈泰子、堀里子、大谷壽一、澤田康文
- Journal Title
  
  薬学雑誌 129(6)
  
  Pages: 773-80
- NAID
  130000136184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20650124
[Journal Article] Transplacental pharmacokinetics of diclofenac in perfused human placenta.2009
- Author(s)
  K. Shintaku, S. Hori, M. Tsujimoto, H. Nagata, S. Satoh, K. Tsukimori, H. Nakano, T. Fujii, Y. Taketani, H. Ohtani, Y. Sawada
- Journal Title
  
  Drug Metab Dispos. 37(5)
  
  Pages: 962-968
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390040
[Journal Article] Assessment of the α1-Adorenoceptor Antagonists in Benign Prostatic Hyperplasia Based on the Receptor Occupancy Theory.2007
- Author(s)
  K.Ito, H.Ohtani, Y.Sawada
- Journal Title
  
  Br.J.Clin.Pharmacol. 63
  
  Pages: 393-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Piloerection induced by replacing fluvoxamine with milnacipran.2007
- Author(s)
  S.Hori, N.Matsuo, A.Yamamoto, T.Hazui, H.Yagi, M.Nakano, Y.Suzuki, A.Miki, H.Ohtani, Y.Sawada
- Journal Title
  
  Br.J.Clin.Pharmacol. 63
  
  Pages: 665-671
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Antacid interaction with new quinolones : Dose regime recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations.2007
- Author(s)
  K.Miyata, H.Ohtani, M.Tsujimoto, Y.Sawada
- Journal Title
  
  Intl.J.Clin.Pharmacol.Ther. 45
  
  Pages: 63-70
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.2007
- Author(s)
  K. Shintaku, Y. Arima, Y. Dan, T. Takeda, K. Kogushi, M. Tsujimoto, H. Nagata, S. Satoh, K. Tsukimori, H. Nakano, S. Hori, H. Ohtani and Y. Sawada
- Journal Title
  
  Drug Metabolism & Disposition 35(5)
  
  Pages: 772-778
- Data Source
  KAKENHI-PROJECT-16689013
[Journal Article] Piloerection induced by replacing fluvoxamine with milnacipran2007
- Author(s)
  S.Hori, N.Matsuo, A.Yamamoto, T.Hazui, H.Yagi, M.Nakano, Y.Suzuki, A.Miki, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology (印刷中)
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Antacid interaction with new quinolones : Dose regime recommendations based on pharmacokinetic modeling of clinical data for ciprofloxacin, gatifloxacin and norfloxacin and metal cations.2007
- Author(s)
  K.Miyata, H.Ohtani, M.Tsujimoto, Y.Sawada
- Journal Title
  
  International Journal of Clinical Pharmacology and Therapeutics 45
  
  Pages: 63-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium.2007
- Author(s)
  S.Inoue, H.Ohtani, M.Tsujimoto, S.Hori, Y.Sawada
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 22・3(印刷中)
- NAID
  130004462990
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta.2007
- Author(s)
  K. Shintaku, Y. Arima, Y. Dan, T. Takeda, K. Kogushi, M. Tsujimoto, H. Nagata, S. Satoh, K. Tsukimori, H. Nakano, S. Hori, H. Ohtani, Y. Sawada
- Journal Title
  
  Drug Metab. Dispos. 35(5)
  
  Pages: 772-778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390040
[Journal Article] Assessment of the alpha-adorenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theory.2007
- Author(s)
  K.Ito, H.Ohtani, Y.Sawada Y.
- Journal Title
  
  British Journal of Clinical Pharmacology 63
  
  Pages: 393-403
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Piloerection induced by replacing fluvoxamine with milnacipran2007
- Author(s)
  S.Hori, N.Matsuo, A.Yamamoto, T.Hazui, H.Yagi, M.Nakano, Y.Suzuki, A.Miki, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology 63
  
  Pages: 665-671
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists.2006
- Author(s)
  A.Ohnishi, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology 61
  
  Pages: 671-676
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists.2006
- Author(s)
  A.Ohnishi, H.Ohtani, Y.Sawada
- Journal Title
  
  Br.J.Clin.Pharmacol. 61
  
  Pages: 671-676
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacist Questionnaire on Pharmaceutical Response to Patients' Poor Compliance [in Japanese]2006
- Author(s)
  A.Hisazumi, H.Ohtani, A.Miki, S.Hori, Y.Sawada
- Journal Title
  
  Jpn.J.Drug Inform. 8
  
  Pages: 133-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Dosage adjustment of quinolone antibiotics and angiotensin converting enzyme inhibitors in patients with renal dysfunction.2006
- Author(s)
  H.Ohtani, Y.Kinoshita, Y.Nagasaki, H.Sata, A.Miki, M.Tsujimoto, Y.Sawada
- Journal Title
  
  International Journal of Clinical Pharmacology and Therapeutics 44
  
  Pages: 428-437
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Major determinant factors of the extent of interaction between grapefruit juice and calcium channel antagonists.2006
- Author(s)
  A.Ohtani, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology (印刷中)
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Dosage adjustment of quinolone antibiotics and angiotensin converting enzyme inhibitors in patients with renal dysfunction.2006
- Author(s)
  H.Ohtani, Y.Kinoshita, Y.Nagasaki, H.Sata, A.Miki, M.Tsujimoto, Y.Sawada
- Journal Title
  
  Intl.J.Clin.Pharmacol.Ther. 44
  
  Pages: 428-437
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacokinetics modeling of the interaction between St John's wort and cyclosporine2006
- Author(s)
  Y.Murakami, T.Tanaka, H.Murakami, M.Tsujimoto, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology (印刷中)
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacokinetic modeling of the interaction between St John's wort and cyclosporine2006
- Author(s)
  Y.Murakami, T.Tanaka, H.Murakami, M.Tsujimoto, H.Ohtani, Y.Sawada
- Journal Title
  
  British Journal of Clinical Pharmacology 62
  
  Pages: 196-199
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] モルヒネ製剤の剤形変更時の薬剤師の対応に関する研究2006
- Author(s)
  久澄礼子, 大谷壽一, 堀里子, 澤田康文
- Journal Title
  
  医薬品情報学 8
  
  Pages: 205-211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Dosage adjustment of quinolone antibiotics and angiotensin converting enzyme inhibitors in patients with renal dysfunction.2006
- Author(s)
  H.Ohtani, Y.Kinoshita, Y.Nagasaki, H.Sata, A.Miki, M.Tsujimoto, Y.Sawada.
- Journal Title
  
  International Journal of Clinical Pharmacology and Therapeutics 44
  
  Pages: 428-437
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] 適正な処方設計・調剤支援システムのための医薬品製剤情報の規格化[技術ノート]2006
- Author(s)
  佐田宏子, 澤田康文, 大谷壽一
- Journal Title
  
  医療情報学 26
  
  Pages: 209-214
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] 服薬不遵守時の薬剤師の対応に関する実状と問題点.2006
- Author(s)
  久澄礼子, 大谷壽一, 三木晶子, 堀里子, 澤田康文
- Journal Title
  
  医薬品情報学 8
  
  Pages: 133-136
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] 医薬品の薬名類似度を評価するための新規指標の構築とその評価2006
- Author(s)
  大谷壽一他
- Journal Title
  
  薬学雑誌 (印刷中)
- Data Source
  KAKENHI-PROJECT-16650031
[Journal Article] 服薬不遵守時の薬剤師の対応に関する実状と問題点.2006
- Author(s)
  久澄礼子, 大谷壽一, 三木晶子, 堀里子, 澤田康文
- Journal Title
  
  医薬品情報学 8
  
  Pages: 133-136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacokinetic modelling of the interaction between St John's wort and cyclosporine.2006
- Author(s)
  Y.Murakami, T.Tanaka, H.Murakami, M.Tsujimoto, H.Ohtani, Y.Sawada
- Journal Title
  
  Br.J.Clin.Plumnacol. 62
  
  Pages: 196-199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacist Questionnaire on Pharmaceutical Supports for the alteration of the dosage form of Morphine [in Japanese]2006
- Author(s)
  A.Hisazumi, H.Ohtani, S.Hori, Y.Sawada
- Journal Title
  
  Jpn.J.Drug Inform. 8
  
  Pages: 205-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release.2005
- Author(s)
  A.Matsui-Sakata, H.Ohtani, Y.Sawada
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 20
  
  Pages: 187-199
- NAID
  10016453807
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Functional analysis of organic cation transporter 3 expressed in human placenta.2005
- Author(s)
  R.Sata, H.Ohtani, M.Tsujimoto, H.Murakami, N.Koyabu, T.Nakamura, T.Uchiumi, M.Kuwano, H.Nagata, K.Tsukimori, H.Nakano, Y.Sawada
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics 315
  
  Pages: 888-895
- Data Source
  KAKENHI-PROJECT-16689013
[Journal Article] Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus.2005
- Author(s)
  A.Matsui-Sakata, H.Ohtani, Y.Sawada
- Journal Title
  
  Drug Metabolism and Pharmacokinetics 20
  
  Pages: 368-378
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus.2005
- Author(s)
  A.Matsui-Sakata, H.Ohtani, Y.Sawada
- Journal Title
  
  Drug Metab.Pharmacokinet. 20
  
  Pages: 368-378
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release.2005
- Author(s)
  A.Matsui-Sakata, H.Ohtani, Y.Sawada
- Journal Title
  
  Drug Metab.Pharmacokinet. 20
  
  Pages: 187-199
- NAID
  10016453807
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Journal Article] Development of a pharmacokinetic model to optimize the dosage regimen of TS-1, a combination preparation of tegafur, gimeracil and oteracil potassium.
- Author(s)
  S.Inoue, H.Ohtani, M.Tsujimoto, S.Hori, Y.Sawada
- Journal Title
  
  Drug Metabol.Pharmacokinet. (in press)
- NAID
  130004462990
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390043
[Presentation] CYP2C9 遺伝的変異型における resveratrol および sesamin の阻害特性の比較2020
- Author(s)
  稲田理乃, 秋好健志, 今岡鮎子, 大谷壽一
- Organizer
  日本薬学会第 140 年会
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] ジャバラ (Citrus jabara) に含まれる narirutin の OATP1A2 阻害プロファイル2020
- Author(s)
  森田時生, 秋好健志, 矢島広大, 今岡鮎子, 植草義徳, 木内文之, 片山和浩, 大谷壽一
- Organizer
  医療薬学フォーラム 2020
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] かんきつ果汁中の新規 OATP2B1 阻害成分の探索とその阻害活性の定量的評価2019
- Author(s)
  森田時生、秋好健志、矢島広大、今岡鮎子、植草義徳、木内文之、片山和浩、杉本芳一、大谷壽一
- Organizer
  第13回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] 薬物相互作用臨床試験をもとにした代謝経路寄与率算出の妥当性の評価2019
- Author(s)
  肥沼佳菜, 土谷聡耀, 秋好健志, 今岡鮎子, 大谷壽一
- Organizer
  第３回フレッシャーズカンファランス
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] ヒト有機アニオン輸送ポリペプチド OATP1A2 の pH 依存的輸送特性2019
- Author(s)
  森田時生、秋好健志, 片岡寛樹、矢島広大、今岡鮎子、片山和浩、杉本芳一、大谷壽一
- Organizer
  日本薬学会第 139 年会
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] High and low affinity kinetics of OATP2B1 - Inhibitory potency and pH-dependency of inhibitors -.2019
- Author(s)
  Ryo Sato, Takeshi Akiyoshi, Ayuko Imaoka, Kazuhiro Katayama, Yoshikazu Sugimoto, Hisakazu Ohtani
- Organizer
  日本薬物動態学会第 34 回年会
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] Comparative analysis of human cytochrome P450 2C19 enzyme kinetics among six variants.2019
- Author(s)
  Daichi Watanabe, Miyuki Shimoji, Hiroyuki Seki, Takeshi Akiyoshi, Ayuko Imaoka, Akikazu Murakami, Hidehiro Kishimoto, Norie Murayama, Hiroshi Yamazaki, Katsunori Nakamura, Hisakazu Ohtani
- Organizer
  9th AASP Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] ヒト小腸有機アニオン輸送ポリペプチド (OATP) 1A2, および OATP2B1 の pH sensitive な輸送特性の解析2018
- Author(s)
  森田時生、佐藤稜、秋好健志, 今岡鮎子、片山和浩、杉本芳一、大谷壽一
- Organizer
  第 62 回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] CYP2C19 代謝活性に対する天然果実成分の阻害様式及びキネティクスの評価2018
- Author(s)
  関博行, 秋好健志, 今岡鮎子, 大谷壽一.
- Organizer
  日本薬学会第 138 年会
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] ヒト小腸有機アニオン輸送ポリペプチド OATP1A2 および 2B1 の輸送能の pH 依存性2018
- Author(s)
  森田時生、佐藤稜、秋好健志, 今岡鮎子、片山和浩、杉本芳一、大谷壽一
- Organizer
  日本医療薬学会第2回フレッシャーズ・カンファランス
- Data Source
  KAKENHI-PROJECT-18K06758
[Presentation] CYP3A4 genetic variants に対する各種アゾール系抗真菌薬の阻害特性の比較2017
- Author(s)
  川村豪, 今岡鮎子, 秋好健志, 日比野英幸, 荒木拓也, 宮崎光江, F.P Guengerich, 中村克徳, 中村智徳, 山本康次郎, 大谷壽一
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] グレープフルーツジュース成分および resveratrol の CYP2C9 阻害特性解析2017
- Author(s)
  内山茉里夏, 秋好健志, 今岡鮎子, 大谷壽一
- Organizer
  日本薬学会第 137 年会
- Place of Presentation
  仙台国際センター (宮城県仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] CYP3A4 各変異型分子種の代謝活性に対する MBI 阻害剤の阻害強度の体系的比較2016
- Author(s)
  内藤里菜、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県・横浜市)
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] CYP3A4 遺伝的 variant に対する競合阻害剤の阻害特性の体系的比較2015
- Author(s)
  綾華奈子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、 F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  第53回日本薬学会関東支部大会
- Place of Presentation
  日本大学薬学部 (千葉県・船橋市)
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K08596
[Presentation] 各種CYP3A4変異型分子種に対するベラパミルおよびその代謝物のMBI特性2015
- Author(s)
  秋好健志、大橋拓人、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4遺伝的variantsに対する各種競合阻害剤の阻害特性の比較2015
- Author(s)
  綾華奈子、小林由季、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、F.P.Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 各種CYP3A4変異型分子に対するグレープフルーツ果汁およびその成分のMBI特性2014
- Author(s)
  秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] In vitro データをもとにした、CYP2D6 variants における paroxetine の非線形体内動態の予測2014
- Author(s)
  丹羽しおり、秋好健志、今岡鮎子、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] CYP3A4変異型分子種におけるtestosterone及びmidazolamの代謝に対する競合阻害剤の阻害強度の比較2014
- Author(s)
  小縣淳子、秋好健志、今岡鮎子、日比野英幸、荒木拓也、宮崎光江、Guengerich FP、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 果実成分によるCYP3A4のMBI特性に対する遺伝子変異の影響2013
- Author(s)
  鈴木恵美、日比野英幸、秋好健志、村瀬沙織、荒木拓也、宮崎光江、Peter Guengerich、中村克徳、中村智徳、山本康次郎、大谷壽一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590668
[Presentation] 服薬に関するトラブル事例発生の規格化とその背後要因分類2009
- Author(s)
  湯本千佳, 堀里子, 三木晶子, 大谷壽一, 澤田康文
- Organizer
  第12回日本医薬品情報学会総会・学術大会
- Place of Presentation
  福岡
- Year and Date
  2009-07-19
- Data Source
  KAKENHI-PROJECT-20659080
[Presentation] CYP3A4のMechanism-based inhibition は基質依存的に生じるか
- Author(s)
  石川裕子、秋好健志、今岡鮎子、大谷壽一
- Organizer
  医療薬学フォーラム2014
- Place of Presentation
  東京
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-24590668

1. SAWADA Yasufumi (80114502)

# of Collaborated Projects: 8 results

# of Collaborated Products: 33 results
2. HORI Satoko (70313145)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
3. KOYABU Noriko (00315102)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. FUJII Tomoyuki (40209010)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. TSUKIMORI Kiyomi (90253450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. AKIYOSHI Takeshi (50399143)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
7. YAMAMOTO Koujirou (70174787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. AOYAMA Takao (60262028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIWADA Hiroshi (50120184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IMAOKA Ayuko (10710957)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
13. 竹田正幸 (50216909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 篠原歩 (00226151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 坂内英夫 (20323644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 畑埜晃平 (60404026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 松尾浩民 (60274479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KOTAKI Hajime

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KIKUCHI Hiroshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 菊地寛

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ohtani Hisakazu 大谷 壽一

OHTANI Hisakazu 大谷 壽一

Research Projects

Research Products

Co-Researchers

Analysis of the inter-individual variations of food-drug interactions via CYP2Cs and OATPsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Quantitative analysis of the factors that confer inter-individual variation of the extent of beverage-drug interactionsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Quantitative analysis of genetic factors affecting the extent of drug interactions via mechanism based inhibition of cytochrome P450Principal Investigator

Principal Investigator

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Research Institution

健康食品の安心・安全確保のための全国ネットワークの構築とその実証に関する研究

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

投薬ミス事例ライブラリーに基づく「事故疫学」確立と事前予測法の開発

Principal Investigator

Project Period (FY)

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Research Institution

Development of system to predict fetal toxicity based on PK/PD evaluation by transplacental transfer and effect of drugs

Principal Investigator

Project Period (FY)

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Research Institution

医療ミス防止をめざした医薬品の製剤・包装関連情報の規格化と有効利用法の確立Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

医薬品情報学及び薬剤学に基づいたジェネリック医薬品の評価・格付け法の開発と評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

医薬品の商標名類似度と処方関連度に基づく投薬ミス防止システム

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

薬物の経胎盤胎児移行における薬物輸送担体の機能的役割に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

DEVELOPMENT OF COMPUTER-AIDED PRESCRIPTION SYSTEM FOR PERSONALIZED PHARMACOTHERAPY BASED ON THE PHAEMACOKINETICS AND PHARMACODYNAMICS

Principal Investigator

Project Period (FY)

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Research Institution

薬剤の催不整脈性に対するリスクファクターとしての性差の解析Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Introduction of tyrosine hydroxylase gene into the cells from brain for the treatment of parkinson's disease.

Principal Investigator

Project Period (FY)

Ohtani Hisakazu 大谷壽一

OHTANI Hisakazu 大谷壽一