TSUNADA Seiji 綱田誠二

Researcher Number	70264158
External Links
Affiliation (based on the past Project Information) *help	2007 – 2010: Saga University, Saga Medical School Dept. of Gastrointestinal Endoscopy, Assistant Professor 2003 – 2006: 佐賀大学, 医学部, 助手 2002: 佐賀医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology
Keywords	Principal Investigator EGF / ODC / glutathione / lipid peroxides / apoptosis / オルニチン脱炭酸酵素活性 / グルタチオン / 過酸化脂質 / アポトーシス Except Principal Investigator 大腸癌 … More / aberrant crypt foci / Colon cancer / azoxymethane / 多価不飽和脂肪酸 / 飽和脂肪酸 / アポトーシス / 共役リノール酸 / Wntシグナル / 共役脂肪酸 / 酸化ストレス / Wnt signaling / triglyiceride / conjugated linoleic acid / free fatty acid / 不飽和脂肪酸 / グルタチオン / 発癌抑制効果 / COX-1選択的阻害剤 / Wnt signal / aberrant crypt foci, / saturated fatty acid, / polyunsaturated fatty acid, / 侵潤癌 / 高脂肪食 / abberant clipt foci / DNA酸価 / 発癌機序 / 異所性クリプト / ω6多価不飽和脂質 / ミトコンドリア / HSP90 / p53 / 細胞増殖 / COX-2 / 発癌抑制 / アラキドン酸カスケード / 脂肪酸 / 脂肪摂取 Less

Differences of the effect of colonic carcinogenesis by various kinds of fatty acids
- Principal Investigator
  
  RYUICHI Iwakiri
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
Clarify the mechanism of colon carcinogenesis by fat intake
- Principal Investigator
  
  IWAKIRI Ryuichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
Dietary saturated fatty acid n-6 poly-unsaturated fatty acid accelerate azoxymethane induced colon carcinogenesis through up-regulation of Wnt/beta-catenin signaling
- Principal Investigator
  
  IWAKIRI Ryuichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
The effect of chronic consumption of lipid peroxides on tumorigenesis in intestine : whether anti-oxidants suppresses tumorigenesis in intestinePrincipal Investigator
- Principal Investigator
  
  TSUNADA Seiji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saga University
  佐賀医科大学
小腸粘膜のアポトーシスの側面からと腸管内過酸化脂質代謝と大腸癌との関連の検討
- Principal Investigator
  
  岩切龍一
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  佐賀医科大学

All 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation Book

[Book] 消化と吸収:Annual Review消化器 89-92.(戸田剛太郎,税所宏光,寺野彰,幕内雅敏,編)2004
- Author(s)
  綱田誠司
- Total Pages
  4
- Publisher
  中外医学社.東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Book] 消化と吸収.:Annual Review消化器 89-92(戸田剛太郎,税所宏光,寺野彰,幕内雅敏,編)2004
- Author(s)
  綱田誠司
- Total Pages
  4
- Publisher
  中外医学社.東京
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients : Evaluation by a case-control study.2011
- Author(s)
  Tsuruoka N, Iwakiri R, Hara M, Shirahama N, Sakata Y, Miyahara K, Eguchi Y, Shimoda R, Ogata S, Tsunada S, Sakata H, Fujimoto K.
- Journal Title
  
  J Gastroenterol Hepatol 26
  
  Pages: 1047-1052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590745
[Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.2010
- Author(s)
  Shiraishi R, Iwakiri R, Fujise T, Kuroki T, Kakimoto T, Takashima T, Sakata Y, Tsunada S, Nakashima Y, Yanagita T, Fujimoto K.
- Journal Title
  
  J.Gastroenterol. 45
  
  Pages: 625-635
- NAID
  10027216628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590745
[Journal Article] Long-term ingestion of reduced glutathione suppressed an accelerating effect of beef tallow diet on colon carcinogenesis in rats.2009
- Author(s)
  Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Miao L, Sakata Y, Tsunada S, Noda T, Iwakiri R, Fujimoto K.
- Journal Title
  
  J Gastroenterol. 44
  
  Pages: 1026-1035
- NAID
  10025581768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590745
[Journal Article] Indigestible material attenuated changes in apoptosis in the fasted rat jejunal mucosa.2008
- Author(s)
  Kakimoto T, Fujise T, Shiraishi R, Kuroki T, Park JM, Ootani A, Sakata Y, Tsunada S, Iwakiri R, Fujimoto K.
- Journal Title
  
  Exp Biol Med 233
  
  Pages: 310-316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590745
[Journal Article] Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/{beta}-catenin signaling in rats2007
- Author(s)
  Fujise, T., Iwakiri, R., Kakimoto, T., Shiraishi, R., Sakata, Y., Wu, B., Tsunada, S., Ootani, A., Fujimoto, K
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Journal Article] Differentiation of Gastric Surface Mucous Cells(GSM06) Induced by Air Liquid Interface Is Regulated Partly through Mitogen-Activated Protein Kinase Pathway2007
- Author(s)
  Yokoyama, F., Sakata, Y., Ootani, A., Fujise, T., Kakimoto, T., Amemori, S., Kuroki, T., Tsunada, S., Iwakiri, R., Fujimoto, K
- Journal Title
  
  J. Gastroenterol. Hepatol 22
  
  Pages: 2310-2315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Journal Article] Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro2007
- Author(s)
  memori, S., Ootani, A., Aoki, S., Fujise, T., Shimoda, R., Kakimoto, T., Shiraishi, R., Sakata, Y., Tsunada, S., Iwakiri, R., Fujimoto, K
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Journal Article] T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats.2006
- Author(s)
  Wu B, Ootani A, Iwakiri R, Sakata Y, Fujise T, Amemori S, Yokoyama F, Tsunada S, Toda S, Fujimoto K.
- Journal Title
  
  Exp Biol Med 231(1)
  
  Pages: 91-98
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use in bleeding peptic ulcers in Japan.2006
- Author(s)
  Ootani H, Iwakiri R, Shimoda R, Nakahara S, Amemori S, Fujise T, Kikkawa A, Tsunada S, Sakata H, Fujimoto K.
- Journal Title
  
  J Gastroenterol. 41
  
  Pages: 41-46
- NAID
  10017328407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] Apoptotic pathway in the rat small intestinal mucosa is different between fasting and ischemia-reperfusion.2006
- Author(s)
  Fujise, T., Iwakiri, R., Wu, B., Amemori, S., Kakimoto, T., Yokoyama, F., Sakata, Y., Tsunada, S., Fujimoto, K
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Journal Article] Apoptotic pathway in the rat small intestinal mucosa is different between fasting and ischemia-reperfusion.2006
- Author(s)
  Fujise T, Iwakiri R, Bin W, Amemori S, Kakimoto T, Yokoyama F, Sakata Y, Tsunada S, Fujimoto K.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] Apoptosis in rat jejunal mucosa is regulated partly through the central nervous system, which controls feeding behavior.2005
- Author(s)
  Lin T, Sakata H, Ootani A, Fujise T, Tsunada S, Amemori S, Danjo A, Yokoyama F, Sakata Y, Iwakiri R, Toda S, Fujimoto K.
- Journal Title
  
  J Gastroenterol Hepatol. 20
  
  Pages: 1285-1291
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] Ischemic preconditioning attenuates ischemia-reperfusion-induced mucosal apoptosis by inhibiting the mitochondria-dependent pathway in rat small intestine.2004
- Author(s)
  Wu B, Ootani A, Iwakiri R, Fujise T, Tsunada S, Toda S, Fujimoto K.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] Venous congestion induces mucosal apoptosis via tumor necrosis factor-alpha-mediated cell death in the rat small intestine.2004
- Author(s)
  Wu B, Fujise T, Iwakiri R, Ootani A, Amemori S, Tsunada S, Toda S, Fujimoto K.
- Journal Title
  
  J Gastroenterol. 39
  
  Pages: 1056-1062
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590605
[Journal Article] s-GERDとFunctional Dyspepsia:概念と治療2004
- Author(s)
  綱田誠司
- Journal Title
  
  Pharm Medica. 22(1)
  
  Pages: 17-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] s-GERD and Functional Dyspepsia : Concept & therapy.2004
- Author(s)
  Tsunada S.
- Journal Title
  
  Pharm Medica. 22(1)
  
  Pages: 17-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Digestion and absorption.2004
- Author(s)
  Tsunada S.
- Journal Title
  
  Annual Review Gastroenterology(Hiromitu Saisyo, Akira Terano, Masatoshi Makuuti)
  
  Pages: 89-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and the reversal by glutathione.2003
- Author(s)
  Tsunada S
- Journal Title
  
  Dig.Dis.Sci. 48
  
  Pages: 210-222
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and the reversal by glutathione.2003
- Author(s)
  Tsunada S, Iwakiri R, Noda T, Fujimoto K, Fuseler J, Rhoads CA, Aw TY.
- Journal Title
  
  Dig.Dis.Sci. 48
  
  Pages: 210-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Endoscopic suture with metallic clips for perforation due to endoscopic mucosal resection in the stomach.2003
- Author(s)
  Tsunada S
- Journal Title
  
  Gastrointest.Endosc. 57
  
  Pages: 948-951
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Reply to Hello, Mr.Clips, could you chip in please?2003
- Author(s)
  Tsunada S
- Journal Title
  
  Gastroenterology 125
  
  Pages: 1896-1898
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Endoscopic suture with metallic clips for perforation due to endoscopic mucosal resection in the stomach.2003
- Author(s)
  Tsunada S.
- Journal Title
  
  Gastrointest Endosc. 57
  
  Pages: 948-951
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Redox imbalance in the colonic mucosa of ulcerative colitis.2003
- Author(s)
  Tsunada S, Iwakiri R, Ootani H, Aw TY, Fujimoto K.
- Journal Title
  
  Scand.J.Gastroenterol 38
  
  Pages: 1002-1003
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Reply to Hello, Mr.Clips, could you chip in please?2003
- Author(s)
  Tsunada S, Iwakiri R, Sakata H, Ogata S, Fujimoto K.
- Journal Title
  
  Gastroenterology 125
  
  Pages: 1896-1989
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Chronic lipid hydroperoxide stress suppresses mucosal proliferation in rat intestine : potentiation of ornithine decarboxylase activity by epidermal growth factor.2003
- Author(s)
  Tsunada S
- Journal Title
  
  Dig.Dis.Sci. 48
  
  Pages: 2333-2341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Reply to Hello, Mr. Clips, could you chip in please?2003
- Author(s)
  Tsunada S
- Journal Title
  
  Gastroenterology 125
  
  Pages: 1896-1898
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Redox imbalance in the colonic mucosa of ulcerative colitis.2003
- Author(s)
  Tsunada S
- Journal Title
  
  Scand.J.Gastroenterol 38
  
  Pages: 1002-1003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Journal Article] Chronic lipid hydroperoxide stress suppresses mucosal proliferation in rat intestine: potentiation of ornithine decarboxylase activity by epidermal growth factor.2003
- Author(s)
  Tsunada S, Iwakiri R, Fujimoto K, Aw TY.
- Journal Title
  
  Dig.Dis.Sci. 48
  
  Pages: 2333-2341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590659
[Presentation] 高脂肪摂取ラットにおける抗酸化物質の大腸発癌に及ぼす影響2009
- Author(s)
  白石良介、藤瀬剛弘、柿本隆志、綱田誠司、岩切龍一、藤本一眞
- Organizer
  5回日本消化管学会総会学術集会抄録集264
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590745
[Presentation] 牛脂長期摂取ラットにおける大腸発癌抑制効果の検討2009
- Author(s)
  白石良介、藤瀬剛弘、綱田誠司、野田隆博、岩切龍一、藤本一眞
- Organizer
  第95回日本消化器病学会総会日消誌106:A310
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20590745
[Presentation] Glutathione, antioxidant, affects colon carcinogenesis induced by long term feeding of beef tallow diet in rats pretreated with azoxymethane.2008
- Author(s)
  Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Amemori S, Tsunada S, Iwakiri R, Fujimoto K.
- Organizer
  16th UEGW. Gut 57 (Suppl.II) : A457
- Place of Presentation
  Vienna
- Data Source
  KAKENHI-PROJECT-20590745
[Presentation] Enhanced colon carcinogenesis with high beef tallow diet in rats was attenuated by conjugated linoleic acid.2008
- Author(s)
  Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Amemori S, Tsunada S, Iwakiri R, Yanagita T, Fujimoto K.
- Organizer
  16th UEGW. Gut 57 (Suppl.II) : A457
- Place of Presentation
  Vienna
- Data Source
  KAKENHI-PROJECT-20590745
[Presentation] Mechanism of colon carcinogenesis induced by dietary fatty acid and accelerating Wnt signaling2007
- Author(s)
  Shiraishi, R., Fujise, T., Kakimoto, T., Kuroki, T., Yamaguchi, K., Watanabe, K., Ootani, H., Shimoda, R., Tsunada, S., Sakata, H., Iwakiri, R., Fujimoto, K
- Organizer
  108th Annual Meeting of the American Gastroenterological Association, DDW
- Place of Presentation
  Washington, DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Presentation] Dietary fatty acid composition and GSH affect rat colon carcinogenesis2007
- Author(s)
  Shiraishi, R., Fujise, T., Kakimoto, T., Kuroki, T., Yamaguchi, K., Watanabe, K., Ootani, H., Shimoda, R., Tsunada, S., Sakata, H., Iwakiri, R., Fujimoto, K
- Organizer
  108th Annual Meeting of the American Gastroenterological Association DDW
- Place of Presentation
  Washington, DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Presentation] Effects of dietary fatty acid composition on rat colon carcinogenesis2006
- Author(s)
  Fujise, T., Kakimoto, T., Shiraishi, R., Yamaguchi, K., Amemori, S., Sakata, Y., Tsunada, S., Iwakiri, R., Fujimoto, K
- Organizer
  107th Annual Meeting of the American Gastroenterological Association
- Place of Presentation
  Los Angeles
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691
[Presentation] Increase in carcinogenesis induced by beef tallow and corn oil through Wnt/beta-catenin signaling pathway is attenuated by fish oil and olive oil in the azoxymethane-induced rat colon cancer model2006
- Author(s)
  Fujise, T., Iwakiri, R., Kakimoto, T., Shiraishi, R., Sakata, Y., Wu, B., Tsunada, S., Ootani, A., Fujimoto, K
- Organizer
  14th UEGW
- Place of Presentation
  Berlin
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590691

1. RYUICHI Iwakiri (70232642)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. TODA Shuji (80188755)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results

TSUNADA Seiji 綱田 誠二

Research Projects

Research Products

Co-Researchers

Differences of the effect of colonic carcinogenesis by various kinds of fatty acids

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarify the mechanism of colon carcinogenesis by fat intake

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dietary saturated fatty acid n-6 poly-unsaturated fatty acid accelerate azoxymethane induced colon carcinogenesis through up-regulation of Wnt/beta-catenin signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of chronic consumption of lipid peroxides on tumorigenesis in intestine : whether anti-oxidants suppresses tumorigenesis in intestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小腸粘膜のアポトーシスの側面からと腸管内過酸化脂質代謝と大腸癌との関連の検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 消化と吸収:Annual Review消化器 89-92.(戸田剛太郎,税所宏光,寺野彰,幕内雅敏,編)2004

Author(s)

Total Pages

Publisher

Description

Data Source

[Book] 消化と吸収.:Annual Review消化器 89-92(戸田剛太郎,税所宏光,寺野彰,幕内雅敏,編)2004

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients : Evaluation by a case-control study.2011

Author(s)

Journal Title

Data Source

[Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow.2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Long-term ingestion of reduced glutathione suppressed an accelerating effect of beef tallow diet on colon carcinogenesis in rats.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Indigestible material attenuated changes in apoptosis in the fasted rat jejunal mucosa.2008

Author(s)

Journal Title

Data Source

[Journal Article] Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/{beta}-catenin signaling in rats2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Differentiation of Gastric Surface Mucous Cells(GSM06) Induced by Air Liquid Interface Is Regulated Partly through Mitogen-Activated Protein Kinase Pathway2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats.2006

Author(s)

TSUNADA Seiji 綱田誠二