UMAHARA Takahiko 馬原孝彦

Researcher Number	70266477
Affiliation (based on the past Project Information) *help	2018 – 2021: 東京医科大学, 医学部, 客員教授 2011 – 2017: 東京医科大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 52010:General internal medicine-related / Neurology Except Principal Investigator General internal medicine(including psychosomatic medicine) / Basic Section 52010:General internal medicine-related / General pharmacology
Keywords	Principal Investigator 頸動脈プラ－ク / Beclin-1 / オ－トファジ－ / ＴＤＰ-43 / オートファジ－ / Beclin1 / HMGB1 / 14-3-3蛋白 / 分子制御細胞死 / 認知症 … More / 分子制御された細胞死 / 内頚動脈プラ-ク / 動脈硬化 / マクロファ-ジ / 14-3-3タンパク / TDP-43 / オートファーゴソーム / 脳動脈硬化 / BRCA1 / beclin1 / Rubicon / リン酸化TDP-43 / 頚動脈プラ-ク / 脳血管障害 / 血管性認知症 / アルツハイマ－病 / Beclin 1 / 筋萎縮性側索硬化症 / リン酸化TDP43 / 頸動脈 / 血栓 / レビ－小体型認知症 / 脳梗塞 / Ｂｅｃｌｉｎ1 / ＨＭＧＢ1 / １４－３－３蛋白 / 神経細胞死 … More Except Principal Investigator 糖尿病 / アルツハイマー病 / フレイル / Sarcopenia / Alzheimer病 / cingulate island sign / 糖尿病性認知症 / Lewy / DLB / Alzheimer / IMP-SPECT / Cingulate Island Sign / 脳血流SPECT / レビー小体型認知症 / 脳血流 / 認知機能 / 軽度認知機能障害 / シスタチンC / シスタチンＣ / 血清シスタチンＣ / 大脳白質病変容積 / 軽度認知障害 / 前頭前野背外側 / 抑うつ / 大脳白質病変 / アルツハイマ－病 / 白質病変容積 / PVH / DWMH / WMH / MCI / 認知症介護者 / BPSD / 認知症 / 介護うつ / 介護負担感 / 介護者教育 / ヒューマニン / 神経細胞死 Less

Comprehensive study of "molecular-controlled cell death and autophagy" in dementia and cerebrovascular disease in the elderlyPrincipal Investigator
- Principal Investigator
  
  TAKAHIKO UMAHARA
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical University
Exploratory research on treatments for Diabetes-related dementia
- Principal Investigator
  
  KANETAKA HIDEKAZU
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tokyo Medical University
Effects of caregivers' education on depression symptoms and sense of burden of dementia patient caregivers
- Principal Investigator
  
  Sakurai Hirofumi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
The effect of white matter hyperintensity volume on cognition, depressive symptoms, and regional cerebral blood flow in mild cognitive impairment
- Principal Investigator
  
  Hirao Kentaro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Tokyo Medical University
Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1Principal Investigator
- Principal Investigator
  
  Umahara Takahiko
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University
Characterization and clinical application of endogenous Alzheimer's disease-suppressing factor
- Principal Investigator
  
  MATSUOKA Masaaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical University

All 2021 2020 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment2021
- Author(s)
  Kentaro Hirao, Fumio Yamashita, Shu Sakurai, Akito Tsugawa, Rieko Haime, Raita Fukasawa, Tomohiko Sato, Hidekazu Kanetaka, Takahiko Umahara, Hirofumi Sakurai, Haruo Hanyu, Soichiro Shimizu
- Journal Title
  
  Geriatr Gerontol Int
  
  Volume: 21 Issue: 8 Pages: 644-650
- DOI
  10.1111/ggi.14211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09327
[Journal Article] Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries2020
- Author(s)
  Umahara T, Uchihara T, Hirao K, Shimizu S, Hashimoto T, Akimoto J, Kohno M, Hanyu H.
- Journal Title
  
  Histol Histopathol
  
  Volume: 35 Pages: 159-167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426
[Journal Article] Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.2020
- Author(s)
  Umahara T, Uchihara T, Hirao K, Shimizu S, Hanyu H.
- Journal Title
  
  Histology and Histopathology
  
  Volume: 35 Pages: 1023-1028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426
[Journal Article] Essential autophagic protein Beclin 1 localizes to atherosclerotic lesions of human carotid and major intracranial arteries2020
- Author(s)
  Umahara Takahiko、Uchihara Toshiki、Hirao Kentaro、Shimizu Soichiro、Hashimoto Takao、Kohno Michihiro、Hanyu Haruo
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 414 Pages: 116836-116836
- DOI
  10.1016/j.jns.2020.116836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07426, KAKENHI-PROJECT-17H03555
[Journal Article] 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease2018
- Author(s)
  Wakabayashi Kaori、Umahara Takahiko、Hirokawa Katsuiku、Hanyu Haruo、Uchihara Toshiki
- Journal Title
  
  Neuroscience Letters
  
  Volume: 674 Pages: 171-175
- DOI
  10.1016/j.neulet.2018.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14572, KAKENHI-PROJECT-26461282, KAKENHI-PROJECT-17H03555
[Journal Article] 14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis,2016
- Author(s)
  Umahara T, Uchihara T, Shibata N, Nakamura A, Hanyu H
- Journal Title
  
  Brain Res
  
  Volume: 1646 Pages: 132-8
- DOI
  10.1016/j.brainres.2016.05.051
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430057, KAKENHI-PROJECT-25670427, KAKENHI-PROJECT-26461282, KAKENHI-PROJECT-16K14572
[Presentation] 軽度認知障害における局所大脳白質病変容積と認知機能との関連2020
- Author(s)
  櫻井周,平尾健太郎,山下典生,都河明人,ハイメ理恵子,深澤雷太,佐藤友彦,金高秀和,馬原孝彦,櫻井博文,羽生春夫,清水聰一郎
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K09327
[Presentation] 脳梗塞剖検脳における急性期および慢性期でのHMGB1局在の差異2017
- Author(s)
  馬原孝彦、山川仁子、櫻井博文、羽生春夫
- Organizer
  第51回日本成人病（生活習慣病）学会学術集会
- Place of Presentation
  東京都千代田区
- Year and Date
  2017-01-14
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 14-3-3 sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites of the patients　with Lewy body disease2017
- Author(s)
  Umahara　Ｔ, Wakabayashi　Ｋ Hirokawa Ｋ, Hanyu Ｈ , Uchihara　Ｔ
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 免疫組織化学から認知症治療開発へ向けての情報提示2017
- Author(s)
  馬原孝彦
- Organizer
  日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 高齢者脳動脈および脳実質病変でのHMGB1の発現様式2016
- Author(s)
  馬原孝彦　廣瀬大輔　深沢雷太　清水聰一郎　山川仁子　平尾健太郎　金高秀和　櫻井博文　羽生春夫内原俊記
- Organizer
  第58回日本老年医学会学会学術集会
- Place of Presentation
  石川県金沢市
- Year and Date
  2016-06-08
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] Localizaｔon of Beclin-1 in　human main cerebral and　caroed arteries2016
- Author(s)
  Takahiko Umahara, Shoichiro Shimizu, Kentaro Hirao, Haruo Hanyu, Toshiki Uchihara
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] Immunohistochemical Examination of Human Mural Thrombus Associated with Carotid Plaques2016
- Author(s)
  Takahiko Umahara, Haruo Hanyu, Toshiki Uchihara
- Organizer
  the 9th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2016-10-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 脳細動脈におけるマクロファ－ジとHMGB 1蛋白の局在2016
- Author(s)
  馬原　孝彦
- Organizer
  第50回日本成人病（生活習慣病）学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2016-01-17
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 急性期脳梗塞剖検脳でのHMGB 1の発現様式-抗体治療の基礎的研究として-2016
- Author(s)
  馬原　孝彦
- Organizer
  第41回日本脳卒中学会総会
- Place of Presentation
  札幌市
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] オ－トファジ－関連物質Beclin 1の頸動脈硬化病変での発現－第二報－2015
- Author(s)
  馬原　孝彦
- Organizer
  第57回日本老年医学会学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2015-06-14
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] Immunolocalization of 14-3-3 proteins in atheroslerotic lesions of human carotid and main cerebral arteries2015
- Author(s)
  馬原　孝彦
- Organizer
  International Association of Gerontology and Geriatrics Asia/Oceania 2015 Congress
- Place of Presentation
  チェンマイ　タイ
- Year and Date
  2015-10-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 主幹脳動脈および頸動脈病変でのHMGB1蛋白の局在意義-続報-2015
- Author(s)
  馬原　孝彦
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟市
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] ダメ－ジ関連分子パタ－ンHMGB 1蛋白の局在様式-脳卒中治療応用への基礎的検討-
- Author(s)
  馬原　孝彦
- Organizer
  日本脳卒中学会総会
- Place of Presentation
  広島県広島市　リーガロイヤルホテル広島
- Year and Date
  2015-03-26 – 2015-03-27
- Data Source
  KAKENHI-PROJECT-26461282
[Presentation] 障害関連分子HMGB1の分布-「炎症と認知機能障害」の基礎的検討として-
- Author(s)
  馬原　孝彦
- Organizer
  日本認知症学会総会学術集会
- Place of Presentation
  神奈川県横浜市　パシフィコ横浜
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461282

1. 羽生春夫 (10228520)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. 清水聰一郎 (10385031)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
3. Hirao Kentaro (40516639)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. Sakurai Hirofumi (60235223)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. KANETAKA HIDEKAZU (90385021)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. 秋元治朗 (10212440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 橋本孝朗 (60266517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. 佐藤友彦 (70421071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. MATSUOKA Masaaki (70222297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. IWAMOTO Toshihiko (10246168)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 宮澤啓介 (50209897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 赫寛雄 (70307338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 織田順 (60459500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 深澤雷太 (30795646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 山下典生 (90628455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 河野道宏 (50718707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高田祐輔 (20449193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

UMAHARA Takahiko 馬原 孝彦

Research Projects

Research Products

Co-Researchers

Comprehensive study of "molecular-controlled cell death and autophagy" in dementia and cerebrovascular disease in the elderlyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research on treatments for Diabetes-related dementia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of caregivers' education on depression symptoms and sense of burden of dementia patient caregivers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of white matter hyperintensity volume on cognition, depressive symptoms, and regional cerebral blood flow in mild cognitive impairment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of neuronal death control target 14-3-3 protein / HMGB1 / Beclin1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization and clinical application of endogenous Alzheimer's disease-suppressing factor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Association of regional white matter hyperintensity volumes with cognitive dysfunction and vascular risk factors in patients with amnestic mild cognitive impairment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries2020

Author(s)

Journal Title

Data Source

[Journal Article] Phosphorylated TDP-43 localizes to chronic cerebral infarctions in human brains.2020

Author(s)

Journal Title

Data Source

[Journal Article] Essential autophagic protein Beclin 1 localizes to atherosclerotic lesions of human carotid and major intracranial arteries2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 14-3-3 protein sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites in patients with Lewy body disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 14-3-3 eta isoform colocalizes TDP-43 on the coarse granules in the anterior horn cells of patients with sporadic amyotrophic lateral sclerosis,2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 軽度認知障害における局所大脳白質病変容積と認知機能との関連2020

Author(s)

Organizer

Data Source

[Presentation] 脳梗塞剖検脳における急性期および慢性期でのHMGB1局在の差異2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 14-3-3 sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites of the patients with Lewy body disease2017

Author(s)

UMAHARA Takahiko 馬原孝彦

[Presentation] 14-3-3 sigma isoform co-localizes with phosphorylated α-synuclein in Lewy bodies and Lewy neurites of the patients　with Lewy body disease2017

[Presentation] Localizaｔon of Beclin-1 in　human main cerebral and　caroed arteries2016