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Sugiyama Tsuyoshi  杉山 剛志

… Alternative Names

杉山 剛志  スギヤマ ツヨシ

SUGIYAMA Tsuyoshi  杉山 剛志

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Researcher Number 70268001
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-8517-9067
Affiliation (Current) 2025: 岐阜医療科学大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 岐阜医療科学大学, 薬学部, 教授
2018: 岐阜医療科学大学, 保健科学部, 教授
2016 – 2017: 岐阜薬科大学, 薬学部, 准教授
2009 – 2010: Gifu Pharmaceutical University, 薬学部, 准教授
2004 – 2005: 岐阜薬科大学, 薬学部, 助教授
2001 – 2002: 愛知医科大学, 医学部, 助手
1995 – 1998: 愛知医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Bacteriology (including Mycology) / Biological pharmacy / Bacteriology (including Mycology)
Except Principal Investigator
Bacteriology (including Mycology)
Keywords
Principal Investigator
Toll-like receptors / Lipopolysaccharides / poly I : C / Signaltransduction / Cytokines / Nitric Oxide / Bacterial CpG DNA / Signal transduction / アジュバント / IgA … More / 炎症性腸疾患 / 感染性腸炎 / 腸内細菌叢 / 免疫学 / Rho GTPase / RhoGEF / アクチン重合 / III型分泌機構 / シトロバクター・ローデンティウム / 腸管出血性大腸菌 / poly I:C / LiponolysaccharidesLiponolysaccharides / 感染免疫 / Macrophage / Morphological change / Mitogen-activated protein kinase / Interferon-γ / B-1 cell … More
Except Principal Investigator
HSP / LPS / エンドトキシン / アポトーシス / 肝細胞 / endotoxic shock / hepatocyte / TNF / stress response / apoptosis / endotoxin / lipopolysaccharide / エンドトキシンショック / マウス / ストレス蛋白 / TNFi / peroxynitrite / ニトロチロシン / iNOS / 一酸化窒素 / ストレスタンパク / D-ガラクトサミン / ストレス応答 / 熱ショック蛋白 Less
  • Research Projects

    (9 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (6 People)
  •  Analysis of Intestinal epithelial cell responses inducing secretory IgA as a basis for mucosal immune adjuvant developmentPrincipal Investigator

    • Principal Investigator
      杉山 剛志
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Gihu University of Medical Science
  •  Establishment of intestinal flora modification method for prevention of enterohemorrhagic Escherichia coli infection and inflammatory enteritisPrincipal Investigator

    • Principal Investigator
      杉山 剛志
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      Gihu University of Medical Science
  •  Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant developmentPrincipal Investigator

    • Principal Investigator
      Sugiyama Tsuyoshi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Gihu University of Medical Science
      Gifu Pharmaceutical University
  •  コッホの原則を満たす実験的マウス潰瘍性大腸炎起炎菌の同定Principal Investigator

    • Principal Investigator
      杉山 剛志
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Gifu Pharmaceutical University
  •  Inhibitory mechanism and the target of Toll like receptor signaling inhibitorsPrincipal Investigator

    • Principal Investigator
      SUGIYAMA Tsuyoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Gifu Pharmaceutical University
  •  低濃度LPSに反応するB-1細胞のCD14を介したシグナル伝達経路の解析Principal Investigator

    • Principal Investigator
      杉山 剛志
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Aichi Medical University
  •  THE ROLE OF STRESS PROTEINS IN ENDOTOXIN-INDUCED HEPATIC INJURY

    • Principal Investigator
      YOKOCHI Takashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      AICHI MEDICAL UNIVERSITY
  •  実験的エンドトキシンショックにおけるアポトーシスの関与

    • Principal Investigator
      横地 高志
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Aichi Medical University
  •  細菌内毒素投与による熱ショック蛋白誘導機序

    • Principal Investigator
      YOKOCHI Takashi
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      Aichi Medical University

All 2019 2018 2017 2016 2004

All Journal Article Presentation Book

  • [Book] エンドトキシン・自然免疫研究 21 エンドトキシン・自然免疫研究のフロンティアをめざして2018

    • Author(s)
      早水良、杉山剛志
    • Total Pages
      88
    • Publisher
      医学図書出版株式会社
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Journal Article] The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells2019

    • Author(s)
      Nishikawa Masashi、Nakano Shun、Nakao Hiromu、Sato Katsuya、Sugiyama Tsuyoshi、Akao Yukihiro、Nagaoka Hitoshi、Yamakawa Hisashi、Nagase Takahiro、Ueda Hiroshi
    • Journal Title

      Cellular Signalling

      Volume: 61 Pages: 93-107

    • DOI

      10.1016/j.cellsig.2019.04.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-18K15045, KAKENHI-PROJECT-18J13111, KAKENHI-PROJECT-19K07043
  • [Journal Article] Peyer’s Patches as a Portal for DNA Delivery by <i>Lactococcus lactis</i> <i>in Vivo</i>2018

    • Author(s)
      Ayumu Yano, Keita Takahashi, Yusuke Mori, Shiori Watanabe, Yuki Hanamura, Tsuyoshi Sugiyama, Naoki Inoue
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 41 Issue: 2 Pages: 190-197

    • DOI

      10.1248/bpb.b17-00657

    • NAID

      130006329249

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-16K19127
  • [Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production2004

    • Author(s)
      Sugiyama T. et al.
    • Journal Title

      Microbiology and Immunology 48・12

      Pages: 957-963

    • NAID

      10014092321

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590367
  • [Journal Article] Inhibition of LPS-induced nitric oxide and cytokine production in RAW 264 cells by 2-aminopurine2004

    • Author(s)
      Sugiyama T.et al.
    • Journal Title

      Journal of Endotoxin Research 10・5

      Pages: 340-340

    • Data Source
      KAKENHI-PROJECT-16590367
  • [Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-β production2004

    • Author(s)
      Sugiyama T.et al.
    • Journal Title

      Microbiology and Immunology 48・12

      Pages: 957-963

    • NAID

      10014092321

    • Data Source
      KAKENHI-PROJECT-16590367
  • [Journal Article] 2-aminopurine inhibits lipopolysaccharide-induced nitric oxide production by preventing IFN-beta production.2004

    • Author(s)
      Sugiyama T. et al.
    • Journal Title

      Microbiol Immunol 48(12)

      Pages: 957-963

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590367
  • [Presentation] 上皮細胞でのⅢ型分泌装置を介したアクチン重合はCitrobacter rodentium特異的分泌型IgA産生誘導に必須ではない2019

    • Author(s)
      鶴見駿、髙橋圭太、井上直樹、杉山剛志
    • Organizer
      第31回 微生物シンポジウム
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] KIAA0599 augments TRIF- and Myd88-dependent TLR signaling2018

    • Author(s)
      Tsuyoshi Sugiyama, Kanna Nakao, Ryo Hayami, Takuya Hasegawa, Keita Takahashi, Naoki Inoue, Takahiro Nagase, Hiroshi Ueda
    • Organizer
      Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] A/E病変に伴うアクチンの重合が制御する宿主遺伝子発現2017

    • Author(s)
      安田祐里花、鶴見駿、早水良、惠西丈彦、高橋圭太、井上直樹、 杉山剛志
    • Organizer
      第21 回腸管出血性大腸菌感染症研究会参加
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] 糞便移植を用いたデキストラン硫酸ナトリウム誘発マウス潰瘍性大腸炎モデルにおける腸内細菌叢と病態の関係の解析2017

    • Author(s)
      惠西丈彦、西科冴香、安田祐里花、村岡夏実、加藤大樹、 前川洋一、井上直樹、杉山剛志
    • Organizer
      第54 回日本細菌学会中部支部総会
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] Rhoグアニンヌクレオチド交換因子KIAA0362のToll様受容体シグナルへの影響2017

    • Author(s)
      早水良、杉山剛志
    • Organizer
      第23回日本エンドトキシン・自然免疫研究会
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] Rhoグアニンヌクレオチド交換因子PLEKHG3によるTRIF依存的シグナル増強作用2017

    • Author(s)
      中尾莞奈、早水良、秋元奈央、長谷川拓也、高橋圭太、 井上直樹、長瀬隆弘、上田浩、杉山剛志
    • Organizer
      第54 回日本細菌学会中部支部総会
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] ARHGEF15 augments TRIF-dependent pathway of TLR signaling via enhancing the phosphorylation of IRF-32016

    • Author(s)
      Sugiyama T, Hasegawa T, Takahashi K, Inoue N., Nagase T., Ueda H.
    • Organizer
      14th Biennial Meeting of International Endotoxin and Innate Immunity Society
    • Place of Presentation
      ドイツ・ハンブルグ
    • Year and Date
      2016-09-22
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08241
  • [Presentation] 腸管上皮細胞におけるRho GTPase活性化のToll様受容体シグナルへの影響2016

    • Author(s)
      矢端文彦、中尾莞奈、早水良、田中秀幸、児玉雄大、高橋圭太、井上直樹、 長瀬隆弘、上田浩、杉山剛志
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
    • Place of Presentation
      岐阜
    • Year and Date
      2016-10-30
    • Data Source
      KAKENHI-PROJECT-16K08241
  • 1.  YOKOCHI Takashi (20126915)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  KATO Yutaka (40267985)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  上田 浩 (50253779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  高橋 圭太 (50634929)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 5.  所 俊志 (10551088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  村上 泰介 (40384135)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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