OIKE Masahioro 大池正宏

… Alternative Names

大池正宏オオイケマサヒロ

OIKE Masahiro 大池正宏

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Researcher Number	70271103
Other IDs
External Links
Affiliation (Current)	2025: 九州大学, 医学研究院, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2014: 九州大学, 医学(系)研究科(研究院), 准教授 2007: 九州大学, 医学(系)研究科(研究院), 准教授 2007: Kyushu University, Faculty of Medicine, Associate Professor 2006: Kyushu University, Faculty of Medical Sciences, Associate Professor, 大学院医学研究院, 助教授 2005: Kyushu University, Faculty of Medical Sciences, Associate Professor, 大学院・医学研究院, 助教授 … More 2000 – 2004: 九州大学, 大学院・医学研究院, 講師 2001 – 2003: 九州大学, 大学院・医学研究院, 助教授 1999: Kyushu University, Graduate School of Medical Sciences, Lecturer, 大学院・医学系研究科, 講師 1998: 九州大学, 医学部, 講師 1995: 九州大学, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology Except Principal Investigator General pharmacology / Endocrinology / General pharmacology
Keywords	Principal Investigator 血管内皮細胞 / ATP / カルシウム / TGFβ1 / アクチン / 小分子G蛋白 / チロシンキナーゼ / 機械刺激 / vascular endothelium / パッチクランプ … More / actin stress fibers / tyrosine kinases / small molecule G protein / heparan sulfate proteoglycan / integrin α5β1 / mechanical stress / RhoA / アクチン細胞骨格 / ヘパラン硫酸プロテオグリカン / インテグリンα5β1 / myosin light chain kinase / matrix metalloprotease / Th2 cytokines / muscle contractility / airway smooth muscle cells / ミオシン軽鎖キナーゼ / マトリックスメタロプロテアーゼ / Th2サイトカイン / 平滑筋収縮機構 / 気道平滑筋 / actin / small G protein / tyrosine kinase / Dbl protein / calcium / mechanosensitivity / endothelium / Rho-キナーゼ / Dbl蛋白 / model vessel / L-arginine / nitric oxide synthase / nitric oxide / pulmonary hypertension / モデル血管 / L-アルギニン / 一酸化窒素合成酵素 / 一酸化窒素 / 肺高血圧症 / Calcium / Chloride channel / Mechanical stress / Endothelium / ハッチクランフ法 / カルシウムイオン / 機械的刺激 / クロライドチャネル / 血管内皮 / TGFβ / 創薬 / 上皮間葉移行 / 阻害薬 / インシリコスクリーニング / 血管収縮能 / 内皮由来物質 / 動脈硬化 / 電気泳動 / 培養細胞 / 内因性蛋白 / 血管平滑筋細胞 / アラキドン酸 / クロライド電流 / 機械刺激感受性 … More Except Principal Investigator TRPM4 / RXR / PPARγ / subtype / isoform / リアノジン受容体 / Ca^<2+> / 血管内皮細胞 / actin-cytoskeleton / integrin / Rho A / endothelial cells / smooth muscle / cerebral artery / stretch / 脂質メディエーター / 血管平滑筋細胞 / TRP蛋白質 / 機械刺激感受性チャネル / Ca^<2+>動員機構 / 末梢抵抗血管 / 平滑筋細胞 / 大脳動脈 / 伸展刺激 / 陽イオンチャネル / インテグリン / 血管平滑筋 / 機械刺激受容機構 / 末梢血流 / aromatase / granulosa cell / ovary / アロマターゼ / 顆粒膜細胞 / 卵巣 / skeletal muscle / cardiac muscle / FK506 binding protein / ryanodine receptor / CaィイD12+ィエD1 / CRC / E-C coupling / RYR / FKBP12.6 / FKBP12 / FK506結合タンパク質 / 骨格筋 / 心筋 / FK506結合蛋白質 / ミオシン軽鎖 / IL-4 / IL-13 / サイトカイン / 気道過敏性 / 平滑筋 / 気道 / アルツハイマー病 / 誘導型一酸化窒素合成酵素 / 一酸化窒素 / アポトーシス / アミロイドβ蛋白 Less

In silico screening of small molecule compounds for substitution of neutralizing antibodies.Principal Investigator
- Principal Investigator
  
  OIKE Masahioro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production
- Principal Investigator
  
  ITO Yusii
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto Health Science University
内皮由来血管組織化因子の同定Principal Investigator
- Principal Investigator
  
  大池正宏
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Mechanosensory molecules and mechanical stress-induced primary responses in vascular endothelial cells.Principal Investigator
- Principal Investigator
  
  OIKE Masahiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Pharmacological study on the mechano-sensitive molecules involved in vascular smooth muscle and endothelial cells.
- Principal Investigator
  
  ITO Yushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
アミロイドβ蛋白による大脳皮質微小血管内皮よりの神経作用物質分泌の解析
- Principal Investigator
  
  木村千稚
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Possible involvement of epithelial-smooth muscle functional relationship in developing airway hyperresponsiveness induced by Th2 cytokine.Principal Investigator
- Principal Investigator
  
  OIKE Masahiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
Molecular mechanisms of endothelial mechanosensitivity.Principal Investigator
- Principal Investigator
  
  OIKE Masahiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Regulartory Mechanism of Ovarian Aromatase by Nuclear Receptor, PPARγ : RXR
- Principal Investigator
  
  YANASE Toshihilo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Kyushu University
Alterations of endothelial functions in pulmonary hypertensionPrincipal Investigator
- Principal Investigator
  
  OIKE Masahiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
Specific interaction of FK506 binding protein (FKBP) isoforms with the ryanodine/CaィイD12+ィエD1 release channel subtypes
- Principal Investigator
  
  ITO Yushi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
Secretory actions of volume-regulated chloride channel in vascular endothelial cells.Principal Investigator
- Principal Investigator
  
  OIKE Masahiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
血管内皮細胞における機械刺激受容の細胞内メカニズムの分子薬理学的研究Principal Investigator
- Principal Investigator
  
  大池正宏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University

All 2014 2013 2008 2007 2006 2004 Other

All Journal Article Presentation Book

[Book] Annual Review 2006 呼吸器2006
- Author(s)
  伊東祐之, 大池正宏, 小西秀平(分担執筆)
- Total Pages
  254
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18390075
[Book] Annual Review 2006 呼吸器2006
- Author(s)
  伊東祐之, 大池正宏, 小西秀平(分担執筆)
- Total Pages
  254
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18659069
[Book] Annual Review 2006 呼吸器 (分担執筆)2006
- Author(s)
  伊東祐之, 大池正宏, 小西秀平
- Total Pages
  253
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590197
[Journal Article] Development of vascular smooth muscle contractility by endothelium-derived transforming growth factor β proteins.2014
- Author(s)
  Kimura C, Konishi S, Hasegawa M, Oike M.
- Journal Title
  
  Pflugers Arch: European Journal of Physiology
  
  Volume: 466 Issue: 2 Pages: 369-380
- DOI
  10.1007/s00424-013-1329-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670129
[Journal Article] Dual modulation of airway amooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production2008
- Author(s)
  Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 4191-4199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390065
[Journal Article] Dual modulation of airway smooth muscle contraction by TH2 cytokines via matrix metalloproteinase-1 production2008
- Author(s)
  Ohta, Y., Hayashi, M., Kanenura, T., Abe, K., Ito, Y., Oike, M
- Journal Title
  
  The Journal of Immunology 180
  
  Pages: 4191-4199
- Data Source
  KAKENHI-PROJECT-19390065
[Journal Article] Long-term treatment with TGFβ_1 impairs mechanotransduction in bovine aortic endothelial cells.2007
- Author(s)
  Watanabe M, Oike M, Ohta Y, Ito Y.
- Journal Title
  
  British Journal of Pharmacology 150巻・4号
  
  Pages: 424-433
- Data Source
  KAKENHI-PROJECT-18390075
[Journal Article] Proapoptotic nitric oxide production in amyloid β protein-treated cerebral microvascular endothelial cells.2007
- Author(s)
  Kimura C, Oike M, Watanabe M, Ito Y
- Journal Title
  
  Microcirculation 14巻・2号
  
  Pages: 89-97
- Data Source
  KAKENHI-PROJECT-18659069
[Journal Article] Long-term treatment with TGFβ_1 impairs mechanotransduction in bovine aortic endothelial cells.2007
- Author(s)
  Watanabe M, Oike M, Ohta Y, Ito Y
- Journal Title
  
  British Journal of Pharmacology 150巻・4号
  
  Pages: 424-433
- Data Source
  KAKENHI-PROJECT-18659069
[Journal Article] Proapoptotic nitric oxide production in amyloid β protein-treated cerebral microvascular endothelial cells.2007
- Author(s)
  Kimura C, Oike M, Watanabe M, Ito Y.
- Journal Title
  
  Microcirculation 14巻・2号
  
  Pages: 89-97
- Data Source
  KAKENHI-PROJECT-18390075
[Journal Article] Pivotal of integrin α_5β_1 in hypotonic stress-induced responses of human endothelium.2006
- Author(s)
  Hirakawa M, Oike M, Watanabe M, Karashima Y, Ito Y.
- Journal Title
  
  FASEB Journal 20巻・10号
  
  Pages: 1992-1999
- Data Source
  KAKENHI-PROJECT-18390075
[Journal Article] Sustained contraction and loss of NO production in TGFβ_1-treated endothelial cells.2006
- Author(s)
  Watanabe M, Oike M, Ohta Y, Nawata H, Ito Y.
- Journal Title
  
  British Journal of Pharmacology 149巻・4号
  
  Pages: 355-364
- Data Source
  KAKENHI-PROJECT-18390075
[Journal Article] Sustained contraction and loss of NO production in TGFβ_1-treated endothelial cells.2006
- Author(s)
  Watanabe M, Oike M, Ohta Y, Nawata H, Ito Y
- Journal Title
  
  British Journal of Pharmacology 149巻・4号
  
  Pages: 355-364
- Data Source
  KAKENHI-PROJECT-18659069
[Journal Article] Pivotal role of integrin α_5β_1 in hypotonic stress-induced responses of human endothelium.2006
- Author(s)
  Hirakawa M, Oike M, Watanabe M, Karashima Y, Ito Y
- Journal Title
  
  FASEB Journal 20巻・10号
  
  Pages: 1992-1999
- Data Source
  KAKENHI-PROJECT-18659069
[Journal Article] Constitutive nitric oxide production in bovine aortic and brain microvascular endothelial cells : a comparative study.2004
- Author(s)
  Kimura C, Oike M, Ohnaka K, Nose Y, Ito Y.
- Journal Title
  
  Journal of Physiology 554巻3号
  
  Pages: 721-730
- Data Source
  KAKENHI-PROJECT-16590199
[Presentation] 内皮由来物質による血管平滑筋の組織様構築及び収縮能の形成2014
- Author(s)
  大池正宏、木村千稚
- Organizer
  第67回日本薬理学会西南部会
- Place of Presentation
  産業医科大学
- Year and Date
  2014-11-23
- Data Source
  KAKENHI-PROJECT-25670129
[Presentation] 血管内皮によるA549細胞へのEMT誘導とその抑制の試み2013
- Author(s)
  大池正宏、木村千稚
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25670129
[Presentation] 気道平滑筋細胞における内因性MMP-1による細胞周囲コラーゲン線維の分解とその収縮能調節作用2008
- Author(s)
  大池正宏
- Organizer
  第49回日本平滑筋学会総会
- Place of Presentation
  奈良
- Year and Date
  2008-07-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390075
[Presentation] 血管内皮上清による血管平滑筋細胞のカルシウム動態の変化2007
- Author(s)
  小西秀平, 渡邊未知, 木村千稚, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80 回総会2007年3月15日
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] ヘパリナーゼIIIは血管内皮細胞の機械刺激応答を阻害する2007
- Author(s)
  渡邊未知, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80 回総会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] 血管内皮上清による血管平滑筋細胞のカルシウム動態の変化2007
- Author(s)
  小西秀平, 渡邊未知, 木村千稚, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80回総会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] Digestion of pericellular collagen fibers by endogenous MMP-1 in airway smooth muscle cells2007
- Author(s)
  M., Oike
- Organizer
  The 49th annual meeting of Japan Society of Smooth Muscle Research
- Place of Presentation
  Nara
- Year and Date
  2007-07-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390075
[Presentation] 気道平滑筋におけるTh2サイトカインによるMMP-1の発現とその収縮能への影響2007
- Author(s)
  大池正宏
- Organizer
  第48回日本平滑筋学会総会
- Place of Presentation
  岡山
- Year and Date
  2007-07-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390075
[Presentation] マトリックスメタルプロテアーゼ1 による気道平滑筋の収縮能の変化2007
- Author(s)
  太田良紀, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80 回総会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] 気道平滑筋細胞における内因性MMP-1による細胞周囲コラーゲン線維の分解とその収縮能調節作用2007
- Author(s)
  大池正宏、他
- Organizer
  第49回日本平滑筋学会総会
- Place of Presentation
  橿原市
- Data Source
  KAKENHI-PROJECT-18659069
[Presentation] 気道平滑筋細胞における内因性MM-lによる細胞周囲コラーゲン線維の分解とその収縮能調節作用2007
- Author(s)
  大池正宏, 他
- Organizer
  第49回日本平滑筋学会総会
- Place of Presentation
  橿原市
- Data Source
  KAKENHI-PROJECT-18390075
[Presentation] マトリックスメタロプロテアーゼ1による気道平滑筋の収縮能の変化2007
- Author(s)
  太田良紀, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80回総会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] ヘパリナーゼIIIは血管内皮細胞の機械刺激応答を阻害する2007
- Author(s)
  渡邊未知, 大池正宏, 伊東祐之
- Organizer
  日本薬理学会第80回総会
- Place of Presentation
  名古屋
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-19390065
[Presentation] Effects of Th2 cytokine-induced expression of MMP-1 on tracheal contraction2006
- Author(s)
  M., Oike
- Organizer
  The 48th annual meeting of Japan Society of Smooth Muscle Research
- Place of Presentation
  Okayama
- Year and Date
  2006-07-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390075
[Presentation] 血管及びリンパ管内皮からの恒常的なTGFβの分泌とその腫瘍細胞における上皮間葉移行への関与
- Author(s)
  大池正宏、木村千稚
- Organizer
  第88回薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25670129

1. ITO Yusii (80037506)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. 木村千稚 (90359935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. INOUE Ryuji (30232573)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ONOUE Hitoshi (70221166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YANASE Toshihilo (30239818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAWATA Hajime (10038820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORITA Hiromitsu (30380463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKEUCHI Hiroshi (70304813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRAKAWA Masakazu (20380454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OIKE Masahioro 大池 正宏

大池 正宏 オオイケ マサヒロ

OIKE Masahiro 大池 正宏

Research Projects

Research Products

Co-Researchers

In silico screening of small molecule compounds for substitution of neutralizing antibodies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

内皮由来血管組織化因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanosensory molecules and mechanical stress-induced primary responses in vascular endothelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pharmacological study on the mechano-sensitive molecules involved in vascular smooth muscle and endothelial cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アミロイドβ蛋白による大脳皮質微小血管内皮よりの神経作用物質分泌の解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible involvement of epithelial-smooth muscle functional relationship in developing airway hyperresponsiveness induced by Th2 cytokine.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of endothelial mechanosensitivity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulartory Mechanism of Ovarian Aromatase by Nuclear Receptor, PPARγ : RXR

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Alterations of endothelial functions in pulmonary hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Specific interaction of FK506 binding protein (FKBP) isoforms with the ryanodine/CaィイD12+ィエD1 release channel subtypes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Secretory actions of volume-regulated chloride channel in vascular endothelial cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

血管内皮細胞における機械刺激受容の細胞内メカニズムの分子薬理学的研究Principal Investigator

Principal Investigator

OIKE Masahioro 大池正宏

大池正宏オオイケマサヒロ

OIKE Masahiro 大池正宏