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MATSUZAKI Koichi  松崎 恒一

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… Alternative Names

松崎 恆一  マツザキ コウイチ

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Researcher Number 70278638
Other IDs
Affiliation (based on the past Project Information) *help 2018: 関西医科大学, 医学部, 非常勤講師
2007 – 2012: Kansai Medical University, Faculty of medicine The Third Department of Internal Medicine, Associate Professor
2004 – 2006: 関西医科大学, 医学部, 講師
1996 – 2002: 関西医科大学, 医学部, 講師
1998: 関西医科大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology
Keywords
Principal Investigator
TGF-β / Smad / TGF-β受容体 / 肝細胞癌 / Hepatocellular Carcinoma / 肝線維化 / 肝再生 / TGF-B / TGF-B受容体 / Liver fibrosis … More / Carcinogenesis / TGF-beta / JNK / CDK / シグナル伝達 / 肝発がん / 肝発癌 / アクチビン / TGF-R … More
Except Principal Investigator
自己免疫性膵炎 / IgG4 / PSTI / 硬化性胆管炎 / 動物モデル / 制御性T細胞 / 癌 / 細菌 / シグナル伝達 / 発生・分化 / 癌幹細胞 / 転移 / carbonic anhydrase / lactoferrin / Th1 / autoimmune pancreatitis / IL-10 / Th17 / 原発性硬化性胆管炎 / 免疫学 / 上部消化管学(食道、胃、十二指腸) / 消化管上皮幹細胞 / 消化管粘膜再生 / 腫瘍 / 上皮幹細胞 / TGF-β受容体 / 大腸腫瘍 / TGF β受容体 / TGF-beta / TGF-beta receptor / colon cancer / colon adenoma / 肝癌細胞 / インテグリン / hepatocellular carcinoma / integrin / metastasis / Th2免疫反応 / Th2 balance / 唾液腺炎 / 自己抗体 / regulatory T cell / animal model / WBN / Kob rat / 大腸腫瘍モデルマウス / 腫瘍幹細胞 / 腫瘍化 / 深部浸潤 / 脈管侵襲 / ヒト大腸癌 / ヒト食道癌 / 大腸癌 / 疾患モデルマウス / 癌の発生 / 癌の進展 Less
  • Research Projects

    (14 results)
  • Research Products

    (68 results)
  • Co-Researchers

    (21 People)
  •  Analysis of cancer stem cells and appearance, development and progression of cancer lesions focusing on phosphorylation of the linker region of Smad2/3

    • Principal Investigator
      FUKUI Toshiro
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Mechanisms of liver carcinogenesis through phospho-Smad by gene-targeted micePrincipal Investigator

    • Principal Investigator
      MATSUZAKI Koichi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Identification of a biomarker of the epithelial stem cell and analysis of the regenerative and carcinogenic mechanisms of digestive tract

    • Principal Investigator
      FUKUI Toshiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Pathogenetic mechanisms of autoimmune pancreatitis and sclerosing cholangitis

    • Principal Investigator
      OKAZAKI Kazuichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  The analysis of relationships of lymphocyte differentiation, gastric mucosal immune response, and carcinogenic mechanism to signaling cascade of TGF-β.

    • Principal Investigator
      FUKUI Toshiro
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Immunological study of pathogenesis and fibrosis in autoimmune pancreatitis

    • Principal Investigator
      OKAZAKI Kazuichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  A immunological study of target antigens in patients with autoimmune pancreatitis and animal models

    • Principal Investigator
      OKAZAKI Kazuichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  TGF-β Signal Transduction via MAPK in Hepatocellular Carcinoma and Therapeutic ApplicationPrincipal Investigator

    • Principal Investigator
      MATSUZAKI Koichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Autocrine TGF-β Signal Transaction and Regulalion in Hepatocellular Carcinoma.Principal Investigator

    • Principal Investigator
      MATSUZAKI Koichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Analyses of TGF-β Signal Transduction Mechanisms in Hepatocellular Carcinoma and Applications for its Treatment.Principal Investigator

    • Principal Investigator
      MATSUZAKI Koichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Integrins in hepatocellular carcinoma and antimetastatic therapies

    • Principal Investigator
      NAITOH Yuji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  肝細胞癌におけるTGF-βシグナル伝達機構の解析Principal Investigator

    • Principal Investigator
      松崎 恒一
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  急性肝障害時におけるTGF-β受容体の発現と役割Principal Investigator

    • Principal Investigator
      松崎 恒一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University
  •  Down regulation of TGF-beta receptors in Human colorectal Canter

    • Principal Investigator
      SAWAMURA Takaya
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kansai Medical University

All 2013 2012 2011 2010 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] Future Outlook. In Hepatocellular Carcinoma2013

    • Author(s)
      Murata M., Yoshida K., and Matsuzaki K
    • Total Pages
      10
    • Publisher
      InTech – open science
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Book] 臨床消化器内科2005

    • Author(s)
      松崎 恒一
    • Total Pages
      8
    • Publisher
      日本メデイカルセンター
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Book] 第7回学術集会記録集2005

    • Author(s)
      松崎 恒一
    • Total Pages
      3
    • Publisher
      メディカルトリビューン社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Book] 分子細胞生物学基礎実験法 改訂第2版2004

    • Author(s)
      松崎恒一
    • Total Pages
      7
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Book] Future Outlook. In Hepatocellular Carcinoma (ed. Daria Nahtigel). Early chronic inflammation and subsequent somatic mutations shift phospho-Smad3 signaling from tumor-suppression to fibro-carcinogenesis in human chronic liver diseases.

    • Author(s)
      Murata M, Yoshida K, and Matsuzaki K
    • Publisher
      InTech - open science
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Tak1 mediates agonist-induced rSmad activation and linker region phosphorylation in the neural crest-derived ectomesenchyme during craniofacial development2013

    • Author(s)
      Kenji Yumoto, Penny S. Thomas, Koichi Matsuzaki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C2013

    • Author(s)
      Takashi Yamaguchi, Koichi Matsuzaki
    • Journal Title

      Hepatology Research

      Volume: 43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Phosphorylated Smad2 and Smad3 signaling: Shifting between tumor suppression and fibro-carcinogenesis in chronic hepatitis C2013

    • Author(s)
      Yamaguchi T, Matsuzaki K, Inokuchi R, Kawamura R, Yoshida K, Murata M, Fujisawa J, Fukushima N, Sata M, Kage M, Nakashima O, Tamori A, Kawada N, Tsuneyama K, et al.
    • Journal Title

      Hepatology Res [Epub ahead of print]

      Volume: (In press) Pages: 1327-1342

    • DOI

      10.1111/hepr.12082

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24790724, KAKENHI-PROJECT-22390153
  • [Journal Article] TGF-β-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.2013

    • Author(s)
      Yumoto K, Thomas S, Matsuzaki K.
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 13467-80

    • DOI

      10.1074/jbc.m112.431775

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] TGF-β Signaling in Onset and Progression ofHepatocellular Carcinoma.2012

    • Author(s)
      Meindl-Beinker M, Matsuzaki K.
    • Journal Title

      Digestive Dis

      Volume: 30 Pages: 514-23

    • DOI

      10.1159/000341704

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] TGF-β Signaling in Onset and Progression of Hepatocellular Carcinoma2012

    • Author(s)
      Meindl-Beinker N.M., Matsuzaki K., and Dooley S
    • Journal Title

      Digestive Diseases

      Volume: 30 Pages: 514-523

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Smad phosphoisoform signals in acute and chronic liver injury : similarities and differences between epithelial and mesencliymal cells2012

    • Author(s)
      Matsuzaki K.
    • Journal Title

      Cell & Tissue Research

      Volume: 347 Pages: 225-243

    • DOI

      10.1007/s00441-011-1178-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells2012

    • Author(s)
      Koichi Matsuzaki
    • Journal Title

      Cell & Tissue Res

      Volume: 347 Pages: 225-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Modulation of TGF-β/Smad signaling in hepatic stellate cells during chronic liver injury2012

    • Author(s)
      Yoshida K, Matsuzaki K.
    • Journal Title

      Frontiers in Gastrointestinal Sciences

      Volume: 53 Pages: 1-7

    • DOI

      10.3389/fphys.2012.00053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790724, KAKENHI-PROJECT-22390153
  • [Journal Article] Modulation of TGF-β/Smad signaling in hepatic stellate cells during chronic liver injury2012

    • Author(s)
      Katsunori Yoshida K and Koichi Matsuzaki
    • Journal Title

      Frontiers in Gastrointestinal Science

      Volume: 3 Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer2012

    • Author(s)
      Yijun Wu, Qi Li, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Müllenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Koichi Matsuzaki
    • Journal Title

      PLoS ONE

      Volume: 7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis2011

    • Author(s)
      Kawamata S, Matsuzaki K, et al.
    • Journal Title

      Inflammatory Bowel Disease

      Volume: 7 Pages: 683-695

    • DOI

      10.1002/ibd.21395

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach2011

    • Author(s)
      Toshiro Fukui
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 456-168

    • DOI

      10.1007/s00535-010-0364-8

    • NAID

      10029028438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590878, KAKENHI-PROJECT-21790689, KAKENHI-PROJECT-22790676, KAKENHI-PROJECT-22390153
  • [Journal Article] The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach ; particularly increasing in mucosae of Helicobacter-associated gastritis.2011

    • Author(s)
      Fukui T., Kishimoto M., Nakajima A., Yamashina M., Nakayama S., Kusuda T., Sakaguchi Y., Yoshida K., Uchida K., Nishio A., Matsuzaki K., Okazaki K.
    • Journal Title

      Journal of Gastroenterology

      Volume: 46 Pages: 456-468

    • NAID

      10029028438

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells2011

    • Author(s)
      Matsuzaki Koichi
    • Journal Title

      Cell & Tissue Research

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Smad phosphoisoform signaling specificity : the right place at the right time2011

    • Author(s)
      Matsuzaki K.
    • Journal Title

      Carcinogenesis

      Volume: 32 Pages: 1578-1588

    • DOI

      10.1093/carcin/bgr172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] ウイルス性慢性肝疾患におけるリン酸化Smadを介する線維化・がん化シグナル2011

    • Author(s)
      松崎恒一
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108 Pages: 1363-1373

    • NAID

      10030297930

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Expression of Pituitary Tumor Transforming Gene I (PTTG1)/Securin in hepatitis B virus-associated liver diseases : Evidence for a Hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation.2010

    • Author(s)
      Molina-Jimenez F, Matsuzaki K, et al.
    • Journal Title

      Hepatology

      Volume: 51 Pages: 777-787

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Expression of pituitary tumor transforming gene 1 (PTTG1)/securin in hepatitis B virus-associated liver diseases: evidence for a hepatitis B virus X protein-mediated inhibition of PTTG1 ubiquitination and degradation.2010

    • Author(s)
      Molina-Jimenez F, Benedicto I, Seki T,Okazaki K, Matsuzaki K, et al.
    • Journal Title

      Hepatology

      Volume: 51 Pages: 777-87

    • DOI

      10.1002/hep.23468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Reversible Smad-dependent signaling between tumor suppression and oncogenesis2007

    • Author(s)
      Sekimoto G, Matsuzaki K, Yoshida K, Mori S, Murata M, Seki T, Matsui H, Fujisawa J, Okazaki K.
    • Journal Title

      Cancer Res. 67

      Pages: 5090-6

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590755
  • [Journal Article] Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis (a review)2006

    • Author(s)
      Matsuzaki K.
    • Journal Title

      Histology and Histopathology 21

      Pages: 645-662

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β during carcinogenesis : the shift from epithelial to mesenchymal signaling (a review)2006

    • Author(s)
      Matsuzaki K, Okazaki K.
    • Journal Title

      Journal of Gastroenterology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis2006

    • Author(s)
      Koichi Matsuzaki
    • Journal Title

      Histology and Histopathology 21

      Pages: 645-662

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Notch signaling modulates the nuclear localization of phosphorylated Smad2 and controls the competence of ectodermal cells for activin A2005

    • Author(s)
      Abe T., Furue M., Kondow A., Matsuzaki K., et al.
    • Journal Title

      Mechanisms of Development 122

      Pages: 671-680

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Acceleration of Smad2 and Smad3 phosphorylation via c-Jun N-terminal kinase during human colorectal carcinogenesis2005

    • Author(s)
      Yamagata H., Matsuzaki K., et al.
    • Journal Title

      Cancer Research 65

      Pages: 157-165

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Notch signaling modulates the nuclear localization of carboxy-terminal-phosphorylated smad2 and controls the competence of ectodermal cells for activin A.2005

    • Author(s)
      Abe T, Furue M, Kondow A, Matsuzaki K, Asashima M.
    • Journal Title

      Mechanisms of Development 122

      Pages: 671-680

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and PDGF Signal via JNK-dependent Smad2/3 Phosphorylatio in Rat Hepatic Stellate Cells after Acute Liver Injury.2005

    • Author(s)
      Yoshida K, Matsuzaki K
    • Journal Title

      American Journal of Pathology 166

      Pages: 1029-1039

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and PDGF Signal via JNK-dependent Smad2/3 Phosphorylation in Rat Hepatic Stellate Cells after Acute Liver Injury2005

    • Author(s)
      Yoshida K, Matsuzaki K, Mori S, Tahashi Y, Yamagata H, Furukawa F, Seki T, Nishizawa M, Fujisawa J, Okazaki K.
    • Journal Title

      American Journal of Pathology 166

      Pages: 1029-1039

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Notch signaling modulates the nuclear localization of pSmad2C an controls the competence of ectodermal cells for activin A.2005

    • Author(s)
      Abe T, Furue M, Kondow A, Matsuzaki K
    • Journal Title

      Mechanisms of Development 122

      Pages: 671-680

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and PDGF signal via JNK-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury2005

    • Author(s)
      Yoshida K., Matsuzaki K., et al.
    • Journal Title

      American Journal of Pathology 166

      Pages: 1029-1039

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Acceleration of Smad2 and Smad3 Phosphorylation via c-Jun N-terminal Kinase during Human Colorectal Carcinogenesis2005

    • Author(s)
      Yamagata H, Matsuzaki K, Mori S, Yoshida K, Tahashi Y, Furukawa F, Sekimoto G, Watanabe T, Uemura Y, Sakaida N, Yoshioka K, Kamiyama Y, Seki T, Okazaki K.
    • Journal Title

      Cancer Research 65

      Pages: 157-165

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Acceleration of Smad2 and Smad3 Phosphorylation via c-Ju N-terminal Kinase during Human Colorectal Carcinogenesis2005

    • Author(s)
      Yamagata H, Matsuzaki K
    • Journal Title

      Cancer Reserch 65

      Pages: 157-165

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and HGF Transmit the Signals through JNK-Dependent Amad2/3 Phosphorylation at the Linker Regions2004

    • Author(s)
      Mori S, Matsuzaki K
    • Journal Title

      Oncogene 23

      Pages: 7146-7429

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and HGF Transmit the Signals through JNK-Dependent Smad2/3 Phosphorylation at the Linker Regions2004

    • Author(s)
      Mori S, Matsuzaki K, Yoshida K, Furukawa F, Tahashi Y, Yamagata H, Seki T, Matsui H., Nishizawa M, Fujisawa J., Okazaki K.
    • Journal Title

      Oncogene 23

      Pages: 7416-7429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and HGF Transmit the Signals through JNK-Dependent Smad2/3 Phosphorylation at the Linker Regions2004

    • Author(s)
      Mori S, Matsuzaki K et al.
    • Journal Title

      Oncogene 23

      Pages: 7416-7429

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions2004

    • Author(s)
      Mori S, Matsuzaki K, Okazaki K, et al.
    • Journal Title

      Oncogene. 23(44)

      Pages: 7416-7429

    • Data Source
      KAKENHI-PROJECT-16590645
  • [Journal Article] Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis

    • Author(s)
      Matsuzaki K
    • Journal Title

      Histology and Histopathology (In press)

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β and PDGF Signal via JNK-dependent Smad2/3 Phosphorylation in Rat Hepatic Stellate Cells After Acute Liver Injury.

    • Author(s)
      Yoshida K, Matsuzaki K et al.
    • Journal Title

      American Journal of Pathology (in press)

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β during carcinogenesis : the shift from epithelial to mesenchymal signaling

    • Author(s)
      Koichi Matsuzaki, Kazuichi Okazaki
    • Journal Title

      Journal of Gastroenterology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Smad phospho-isoforms direct context dependentTGF-β signaling

    • Author(s)
      Matsuzaki K.
    • Journal Title

      Cytokine & Growth Factor Review

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Journal Article] Acceleration of Smad2 and Smad3 Phosphorylation via JNK during Human

    • Author(s)
      Yamagata H, Matsuzaki K et al.
    • Journal Title

      Cancer Research (in press)

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] TGF-β during carcinogenesis : the shift from an epithelial to a mesenchymal signaling

    • Author(s)
      Matsuzaki K, Okazaki K
    • Journal Title

      Journal of Gastroenterology (In press)

    • Data Source
      KAKENHI-PROJECT-16590646
  • [Journal Article] Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer

    • Author(s)
      Yijun Wu, Qi Li, Jiren Yu, Yunchuan Mu, Stefan Munker, Chengfu Xu, Zhe Shen, Roman Mullenbach, Yan Liu, Li Li, Norbert Gretz, Derek Zieker, Jun Li, Koichi Matsuzaki, et al
    • Journal Title

      PLoS ONE

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Patent] リンカー領域がリン酸化された Smad3を特異的に認識するモノクローナル抗体2012

    • Inventor(s)
      瀬川辰也、清藤勉、松崎恒一
    • Industrial Property Rights Holder
      株式会社免疫生物研究所
    • Filing Date
      2012-07-07
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Patent] リンカー領域がリン酸化されたSmad3を特異的に認識するモノクローナル抗体2012

    • Inventor(s)
      瀬川辰也、清藤勉、松崎恒一
    • Industrial Property Rights Holder
      瀬川辰也、清藤勉、松崎恒一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible phospho-Smad signaling between tumor-suppression andfibro-carcinogenesis in human chronic liver diseases2013

    • Author(s)
      Matsuzaki K.
    • Organizer
      The 2nd JSGE International Topic Conference / The 8th JSGE-AGA Joint Meeting
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2013-05-02
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] 慢性炎症が惹起する前がん病変のがん化シグナルは、治療介入により、がん抑制シグナルに回帰する:TGF-βシグナル伝達からみた臨床検討2012

    • Author(s)
      松崎恒一
    • Organizer
      第192回日本消化器病学会東北支部例会
    • Place of Presentation
      仙台国際センター、仙台
    • Year and Date
      2012-02-04
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] 原発性胆汁性肝硬変症におけるTGF-βシグナル伝達機構の解析2011

    • Author(s)
      川村梨那子、松崎恒一
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック、東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] 核酸アナログ治療後、B型慢性肝疾患の線維化・癌化シグナルは、癌抑制シグナルに回帰する2011

    • Author(s)
      吉田勝紀、Long Qing、松崎恒一
    • Organizer
      第47回日本肝臓学会総会
    • Place of Presentation
      ホテルグランパシフィック、東京
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible phosphorylated Smad3 signaling between tumor-suppression and fibro-carcinoeenesis in chronic hepatitis C2011

    • Author(s)
      Matsuzaki Koichi
    • Organizer
      The 3^<rd> JCA AACR Special Joint Conference
    • Place of Presentation
      Chiba, Japan
    • Year and Date
      2011-03-02
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Smad phosphoisoform signaling specificity : the right place at the right time2011

    • Author(s)
      Matsuzaki K.
    • Organizer
      70th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya congress center, Nagoya, Japan
    • Year and Date
      2011-10-04
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Smad phosphoisoform signalingspecificity: the right place at the right time2011

    • Author(s)
      Matsuzaki K.
    • Organizer
      70th Annual Meeting of the Japanese CancerAssociation
    • Place of Presentation
      Nagoya, Japan.
    • Year and Date
      2011-10-07
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible phosphorylatedSmad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis C2011

    • Author(s)
      Matsuzaki K.
    • Organizer
      The3^<rd> JCA-AACR Special Joint Conference
    • Place of Presentation
      Chiba,Japan
    • Year and Date
      2011-05-16
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible Smad signaling in chronic liver diseases2010

    • Author(s)
      Matsuzaki Koichi
    • Organizer
      Roche round table seminar
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2010-04-17
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Smad signaling in human liver diseases2010

    • Author(s)
      Matsuzaki Koichi
    • Organizer
      GastroForschung-Kolloquium-2010
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2010-04-15
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Smad signaling in human liver diseases2010

    • Author(s)
      Matsuzaki K.
    • Organizer
      GastroForschung- Kolloquium-2010Heidelberg
    • Place of Presentation
      University, Heidelberg, Germany
    • Year and Date
      2010-04-05
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Smad3 phosphoisoform-mediated signaling during colorectal cancer using chronic colitis mice model2010

    • Author(s)
      Matsuzaki K., Seki T., Okazaki K.
    • Organizer
      61st Annual Meeting, American Association for the Study of Liver Diseases
    • Place of Presentation
      Boston, USA
    • Year and Date
      2010-10-30
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible Smad signaling in chronic liver diseases2010

    • Author(s)
      Matsuzaki K.
    • Organizer
      Roche round tableseminar, Vienna
    • Place of Presentation
      Austria
    • Year and Date
      2010-04-07
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] 急性肝障害時の肝細胞ならびに肝星細胞におけるTGF-βシグナル伝達の検討

    • Author(s)
      村田美樹、松崎恒一
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      全日空ホテル(金沢)
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible phospho-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis B

    • Author(s)
      Katsunori Yoshida, Koichi Matsuzaki
    • Organizer
      The 2nd International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling" TGF-β Family: Signal Network and Tumor Microenvironment
    • Place of Presentation
      昭和薬科大学(東京)
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible or irreversible phospho-Smad2/3 signaling between tumor-suppression and fibro-carcinogenesis in hepatitis C virus-related chronic liver diseases

    • Author(s)
      Miki Murata, Koichi Matsuzaki
    • Organizer
      The 2nd International Symposium by JSPS Core-to-Core Program "Cooperative International Framework in TGF-β Family Signaling" TGF-β Family: Signal Network and Tumor Microenvironment
    • Place of Presentation
      昭和薬科大学(東京)
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible or irreversible phospho-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in hepatitis C virus-related chronic liver diseases

    • Author(s)
      Katsunori Yoshida, Koichi Matsuzaki
    • Organizer
      The 10th JSH Single topic conference "Hepatitis C: Best practice based on science", Tokyo, Japan
    • Place of Presentation
      京王プラザホテル(東京)
    • Data Source
      KAKENHI-PROJECT-22390153
  • [Presentation] Reversible phospho-Smad signaling between tumor-suppression and fibro-carcinogenesis in human chronic liver diseases

    • Author(s)
      Koichi Matsuzaki
    • Organizer
      The 2nd JSGE International Topic Conference / The 8th JSGE-AGA Joint Meeting
    • Place of Presentation
      城山観光ホテル(鹿児島)
    • Invited
    • Data Source
      KAKENHI-PROJECT-22390153
  • 1.  OKAZAKI Kazuichi (70145126)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 6 results
  • 2.  UCHIDA Kazushige (40411516)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 1 results
  • 3.  SEKI Toshihito (70163087)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 5 results
  • 4.  FUKUI Toshiro (60402905)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  NAKAHASHI Yoshitsugu (70247930)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  SAWAMURA Takaya (10105786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TANI Kazuhiro (20257934)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  WATANABE Toshihiko (20201212)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAITOH Yuji (30198014)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NISHIO Akiyoshi (50362463)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  MIYOSHI Hideaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FUKATA Norimasa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KOYABU Masaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KISHIMOTO Masanobu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 15.  TKAHASHI Yu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SUZUKI Ryo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MIYAMOTO Sachi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  MATSUMOTO Yasushi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  TANIMURA Yuji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  常山 幸一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  吉田 勝紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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