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Koike Manabu  小池 学

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… Alternative Names

KOIKE Manabu  小池 学

小池 学  コイケ マナブ

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Researcher Number 70280740
Other IDs
External Links
Affiliation (Current) 2025: 国立研究開発法人量子科学技術研究開発機構, QST病院 重粒子線治療研究部, シニアスタッフ
Affiliation (based on the past Project Information) *help 2021 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 重粒子線治療研究部, 上席研究員
2019 – 2023: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 重粒子線治療研究部, 上席研究員(定常)
2017 – 2018: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 重粒子線治療研究部, 主幹研究員(定常)
2016: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主幹研究員(定常)
2015: 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, チームリーダー … More
2014: 独立行政法人放射線医学総合研究所, 放射線障害研究グループ, 主任研究員
2012 – 2014: 独立行政法人放射線医学総合研究所, その他部局等, 研究員
2012 – 2014: 独立行政法人放射線医学総合研究所, 放射線防護研究センター, 主任研究員
2012: 放射線医学総合研究所, 研究員
2009 – 2011: 独立行政法人放射線医学総合研究所, 放射線障害研究グループ, 主任研究員
2008 – 2010: National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員
2008: 放射線医学総合研究所, 研究員
2006 – 2007: Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Researcher, 生体影響機構, 研究員
2006: National Institute of Radiological Sciences, Research Center for Radiation Protection, Senior Researcher, 放射線防護研究センター, 主任研究員
2005: 独立行政法人放射線医学総合研究所, 研究員
2003: 独立行政法人放射線医学総合研究所, 放射線障害研究グループ, 研究員
2002: 独立行政法人, 放射線医学総合研究所・放射線障害研究グループ, 研究員
2001: 放射線医学総合研究所, 放射線障害研究グループ, 研究員
2000: 放射線医学総合研究所, 第2研究グループ, 研究員
1998: 放射線医学総合研究所, 第2研究グループ, 研究員
1997: 放射線医学総合研究所, 第2研究グループ・第5サブグループ, 研究員
1996: 放射線医学総合研究所, 第2研究グループ, 研究員 Less
Review Section/Research Field
Principal Investigator
環境影響評価(含放射線生物学) / Risk sciences of radiation/Chemicals / Basic Section 63020:Radiation influence-related / Risk sciences of radiation and chemicals
Except Principal Investigator
Risk sciences of radiation/Chemicals / Environmental pharmacy / Basic Section 57020:Oral pathobiological science-related / Basic Section 42020:Veterinary medical science-related / Basic Section 49030:Experimental pathology-related / Basic Section 63020:Radiation influence-related … More / Surgical dentistry / Risk sciences of radiation and chemicals / Veterinary medical science / Carcinogenesis / Biological Sciences Less
Keywords
Principal Investigator
DSB / Ku70 / GFP / Ku80 / DNA repair / 電離放射線 / NHEJ / Mitochondria / Cell tissue / Protein … More / Gene / Radiation / DNA修復 / Kup80 / Kup70 / ku70 / Live cell imaging / XLF / 修復蛋白質 / センサーマウス / DSB損傷 / 可視化 / ミトコンドリア / DNA損傷 / Ku / 非相同末端結合 / 酵素 / 細胞組織 / 蛋白質 / 遺伝子 / 放射線 / DNA二重鎖切断修復 / GFT / localization / 細胞内局在 / Two-hybrid法 / Ku p80 / Ku p70 / 遺伝子ターゲッティング / ノーザンブロット法 / FISH法 / 染色体マッピング … More
Except Principal Investigator
分子シミュレーション / Ku / DNA二本鎖切断 / 重粒子線 / wound healing / keratinocyte / Ah receptor / NHEJ / Ku70 / 放射線 / ライブセルイメージング / 盲腸 / 大腸がん / 炎症 / DNA損傷認識 / 創傷治癒 / ケラチノサイト / Ahレセプター / 皮膚 / AhR / 粘膜悪性黒色腫 / 重粒子線治療j法 / 患者血漿サンプル / 口腔粘膜悪性黒色腫 / 頭頸部悪性粘膜黒色腫 / 悪性粘膜黒色腫 / 重粒子線治療 / 予後予測 / 頭頚部悪性黒色腫 / 粘膜悪性黒色腫細胞株樹立 / PDGF / 血液検体 / miRNA / 頭頚部粘膜悪性黒色腫 / Ku80 / 増感 / がん治療 / イヌ / 発がん / 食餌成分 / 腫瘍形成 / Reg3 / Lgr5 / antimicrobial peptide / FGFR2 / Pitx2 / Reg3b / tumorigenesis / organoid culture / LGR5 / inflammation / IL-1b / tumor formation / ileocecal junction / アセチル化 / 核移行シグナル(NLS) / 核移行シグナル (NLS) / Importin / 核移行シグナル(NLS) / アセチルリジン / DNA二本鎖切断修復 / 口腔がん / 化学療法 / 放射線治療 / EMT / 放射線抵抗性 / 頭頸部粘膜悪性黒色腫 / 放射線治療抵抗性 / 口腔扁平上皮癌 / 重粒子線治療法 / 頭頸部がん / APサイト / DSB修復 / DNA修復 / クラスターDNA損傷 / クラスターDNA損傷修復 / epidermal-mesenchymal transition / skin / Slug / ダイオキシン / 上皮-間葉転換 / 上皮・間葉転換 / 像管財 / XRCC4 / XLF / 犬 / 増感剤 / 伴侶動物 / 損傷認識 / 損傷修復 / DNA損傷修復 / 三次元培養 / β-catenin / サイトカイン / Ah レセプター / 大腸癌 / Kuタンパク質 / 分子動力学シミュレーション / 腸上皮細胞 / 皮脂腺 / 腸 / Blimp1 / 骨髄キメラ / 造血細胞系 / 突然変異 / 色素性乾皮症 / ノックイン / 老化 / 色素性乾皮症G群 / 早期死亡 / 塩基除去修復 / ヌクレオチド除去修復 / 疾患モデルマウス / 二重変異マウス / 色素性乾皮症 G群 / 色素性乾皮症 A群 Less
  • Research Projects

    (23 results)
  • Research Products

    (51 results)
  • Co-Researchers

    (17 People)
  •  超高齢化社会に向けたDNA修復遺伝子Kuの機能解析のパラダイムシフト:加齢影響Principal Investigator

    • Principal Investigator
      小池 学
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63020:Radiation influence-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  伴侶動物の革新的がん治療法開発に向けた次世代型重粒子線増感がん治療薬開発基盤研究

    • Principal Investigator
      小池 亜紀
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  AhRによる腫瘍抑制作用とその欠損マウスにおける腫瘍形成メカニズムの解析

    • Principal Investigator
      生田 統悟
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      Research Institute for Clinical Oncology Saitama Cancer Center
  •  Theoretical and experimental analysis for the nuclear transport mechanism of double-strand break repair protein, Ku70

    • Principal Investigator
      Fujimoto Hirofumi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63020:Radiation influence-related
    • Research Institution
      National Institute of Infectious Diseases
  •  Development of combined therapy utilizing heavy particle radiation treatment for oral mucosal malignant melanoma

    • Principal Investigator
      Fujii Makiko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Hiroshima University
  •  Analysis of repair mechanisms by imaging methods in vivo: Next-generation DSB sensor micePrincipal Investigator

    • Principal Investigator
      KOIKE MANABU
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63020:Radiation influence-related
    • Research Institution
      National Institutes for Quantum Science and Technology
  •  Theoretical and experimental analysis of the binding efficiency of Ku protein to radiation induced clustered DNA damages

    • Principal Investigator
      Fujimoto Hirofumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      National Institute of Infectious Diseases
  •  Establishment of the multidisciplinary treatment for oral cancer using a heavy particle ion radiation therapy

    • Principal Investigator
      Fujii Makiko
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Surgical dentistry
    • Research Institution
      Hiroshima University
  •  Development of a sensor mouse model of DNA damage : next-generation DSB sensor mousePrincipal Investigator

    • Principal Investigator
      KOIKE MANABU
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      National Institutes for Quantum and Radiological Science and Technology
  •  Fundamental study for the development of new radiosensitizers based on the molecular mechanism of DNA double strand break repair of companion animals

    • Principal Investigator
      KOIKE AKI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Veterinary medical science
    • Research Institution
      National Institutes for Quantum and Radiological Science and Technology
  •  A paradigm shift by two Ku80: New model of the radiation-induced DNA damage response mechanism in human cellsPrincipal Investigator

    • Principal Investigator
      KOIKE MANABU
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Radiological Sciences
  •  Structural analysis of the binding mechanism of the Ku protein to DNA that contains overhangs in its end

    • Principal Investigator
      FUJIMOTO HIROFUMI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Infectious Diseases
  •  Suppression of colon tumorigenesis by Ah receptor

    • Principal Investigator
      IKUTA Togo
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Carcinogenesis
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  Structural analysis of the interaction between the Ku protein and DNA

    • Principal Investigator
      FUJIMOTO Hirofumi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Infectious Diseases
  •  Development of a novel DNA damage sensor mouse model.Principal Investigator

    • Principal Investigator
      KOIKE Manabu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Radiological Sciences
  •  Expression and Function of the Ah receptor

    • Principal Investigator
      IKUTA Togo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  DNA double-strand break repair proteins in mitochondria of mammalian cellsPrincipal Investigator

    • Principal Investigator
      KOIKE MANABU
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      National Institute of Radiological Sciences
  •  Biological function of Ah receptor

    • Principal Investigator
      IKUTA Togo
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  GFPにより可視化した非相同末端結合蛋白質によるDNA損傷認識機構に関する研究Principal Investigator

    • Principal Investigator
      小池 学
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      National Institute of Radiological Sciences
  •  XPG欠損マウスを用いたヌクレオチド除去修復と塩基除去修復の相互作用の解析

    • Principal Investigator
      塩見 忠博
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Radiological Sciences
  •  放射線に応答し細胞内局在を変化するDNA二重鎖切断修復蛋白質の同定と機能解析Principal Investigator

    • Principal Investigator
      小池 学
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      National Institute of Radiological Sciences
  •  遺伝子ターゲッティング法を用いた電離放射線高感受性修復欠損マウス系統の樹立Principal Investigator

    • Principal Investigator
      小池 学
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      National Institute of Radiological Sciences
  •  遺伝子ターゲッティング法を用いた電離放射線高感受性修復欠損マウス系統の樹立Principal Investigator

    • Principal Investigator
      小池 学
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      環境影響評価(含放射線生物学)
    • Research Institution
      National Institute of Radiological Sciences

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2005 Other

All Journal Article Presentation

  • [Journal Article] 伴侶動物の革新的がん治療法開発のための次世代重粒子線増感がん治療薬の開発に向けた基礎研究2024

    • Author(s)
      小池学、小池亜紀
    • Journal Title

      Precision Medicine

      Volume: 7 Pages: 60-62

    • Data Source
      KAKENHI-PROJECT-22K06036
  • [Journal Article] Molecular cloning, subcellular localization, and rapid recruitment to DNA damage sites of chicken Ku702024

    • Author(s)
      Koike Manabu、Yamashita Hideji、Yutoku Yasutomo、Koike Aki
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41598-024-51501-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06036
  • [Journal Article] Combined ataxia telangiectasia mutated and DNA-dependent protein kinase inhibition radiosensitizes Madin–Darby canine kidney cells2022

    • Author(s)
      Manabu KOIKE, Yasutomo YUTOKU, Aki KOIKE
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 11 Pages: 1485-1490

    • DOI

      10.1292/jvms.22-0061

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06036
  • [Journal Article] Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites.2022

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      FEBS Open Bio.

      Volume: 12 Issue: 4 Pages: 798-810

    • DOI

      10.1002/2211-5463.13363

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K12337
  • [Journal Article] Detection of double-stranded DNA breaks and apoptosis induced by bleomycin in mouse intestine2021

    • Author(s)
      Ikuta T, Koike A, Koike M.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 46 Issue: 12 Pages: 611-618

    • DOI

      10.2131/jts.46.611

    • NAID

      130008123675

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07437
  • [Journal Article] Feline XLF accumulates at DNA damage sites in a Ku‐dependent manner.2019

    • Author(s)
      Koke M., Yutoku Y., Koike A.
    • Journal Title

      FEBS Open Bio

      Volume: - Issue: 6 Pages: 1052-1062

    • DOI

      10.1002/2211-5463.12589

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Journal Article] Cloning of canine Ku80 and its localization andaccumulation at DNA damage sites.2017

    • Author(s)
      Koke, M., Yutoku, Y., Koike, A.
    • Journal Title

      FEBS Open Bio.

      Volume: 7 Issue: 12 Pages: 1854-1863

    • DOI

      10.1002/2211-5463.12311

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Journal Article] Cloning, localization and focus formation at DNA damage sites of canine XLF2017

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 1 Pages: 22-28

    • DOI

      10.1292/jvms.16-0440

    • NAID

      130005289876

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26450438
  • [Journal Article] Cloning, localization and focus formation at DNA damage sites of canine Ku702017

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 3 Pages: 554-561

    • DOI

      10.1292/jvms.16-0649

    • NAID

      130005466302

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26450438, KAKENHI-PROJECT-16K00554
  • [Journal Article] Cloning, localization and focus formation at DNA damage sites of canine XRCC42016

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 12 Pages: 1865-1871

    • DOI

      10.1292/jvms.16-0381

    • NAID

      130005286386

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26450438
  • [Journal Article] Nuclear localization of mouse Ku70 in interphase cells and focus formation of mouse Ku70 at DNA damage sites immediately after irradiation2015

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 9 Pages: 1137-1142

    • DOI

      10.1292/jvms.14-0651

    • NAID

      130005100717

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24510078
  • [Journal Article] Impact of Amino Acid Substitutions in Two Functional Domains of Ku80: DNA-Damage-Sensing Ability of Ku80 and Survival after Irradiation2014

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 76 Issue: 1 Pages: 51-56

    • DOI

      10.1292/jvms.13-0283

    • NAID

      130003362299

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24510078
  • [Journal Article] The Defect of Ku70 Affects Sensitivity to X-Ray and Radiation-Induced Caspase-Dependent Apoptosis in Lung Cells2013

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 4 Pages: 415-420

    • DOI

      10.1292/jvms.12-0333

    • NAID

      130002502180

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510078
  • [Journal Article] Ku80 attentuates cytotoxicity induced by green fluorescent protein transduction independently of non-homologous end joining.2013

    • Author(s)
      Koike M*, Yutoku Y, Koike A.
    • Journal Title

      FEBS Open Bio

      Volume: 3 Issue: 1 Pages: 46-50

    • DOI

      10.1016/j.fob.2012.12.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510077
  • [Journal Article] A possible overestimation of the effect of acetylation on lysine residues in KQ mutant analysis2012

    • Author(s)
      Hirofumi Fujimoto, Mariko Higuchi, Manabu Koike, Hirotaka Ode, Miroslav Pinak, Juraj Kotulic Bunta, Toshiyuki Nemoto, Takashi Sakudoh, Naoko Honda, Hideaki Maekawa, Kimiaki Saito, Kozo Tsuchida
    • Journal Title

      J. Comput. Chem

      Volume: 33 Issue: 3 Pages: 239-246

    • DOI

      10.1002/jcc.21956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510063, KAKENHI-PROJECT-22310038
  • [Journal Article] Accumulation of Ku70 at DNA double-strand breaks in living epithelial cells2011

    • Author(s)
      Manabu Koike, Yasutomo Yutoku, Aki Koike
    • Journal Title

      Exp. Cell. Res

      Volume: 317 Issue: 17 Pages: 2429-2437

    • DOI

      10.1016/j.yexcr.2011.07.018

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Journal Article] Establishment of Ku70-Deficient Lung Epithelial Cell Lines and Their Hypersensitivity to Low-Dose X-Irradiation2011

    • Author(s)
      Manabu KOIKE, Yasutomo YUTOKU, Aki KOIKE
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 73 Issue: 5 Pages: 549-554

    • DOI

      10.1292/jvms.10-0454

    • NAID

      130000444626

    • ISSN
      0916-7250, 1347-7439
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Journal Article] Establishment of Ku70-deficient lung epithelial cell lines and their hypersensitivity to low-dose X-irradiation2011

    • Author(s)
      Koike M, Yutoku Y, Koike A
    • Journal Title

      Journal of Veterinary Medical Science

      Pages: 549-554

    • NAID

      130000444626

    • Data Source
      KAKENHI-PROJECT-20510059
  • [Journal Article] Establishment of Ku70-Deficient Lung Epithelial Cell Lines and Their Hypersensitivity to Low-Dose X-Irradiation.2010

    • Author(s)
      Koike M, Yutoku Y, Koike A.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: in press

    • NAID

      130000444626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20510059
  • [Journal Article] 放射線によるDNA二本鎖切断損傷とDNA修復酵素の挙動イメージング2005

    • Author(s)
      伊吹裕子, 豊岡達士, 小池亜紀, 小池 学
    • Journal Title

      放射線科学 48

      Pages: 308-315

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510057
  • [Journal Article] Live cell imaging of DNA repair proteins and DNA double-strand breaks by ionizing irradiation2005

    • Author(s)
      Ibuki Y, Toyooka T, Koike A, Koike M
    • Journal Title

      Radiological Sciences 48

      Pages: 308-315

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17510057
  • [Journal Article] Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair.2005

    • Author(s)
      Koike M, Koike A
    • Journal Title

      Exp.Cell.Res. 305

      Pages: 266-276

    • Data Source
      KAKENHI-PROJECT-17510057
  • [Journal Article] Ku70-binding site of Ku80 is required for the stabilization of Ku70 in the cytoplasm, for the nuclear translocation of Ku80, and for Ku80-dependent DNA repair.2005

    • Author(s)
      Koike M, Koike A
    • Journal Title

      Exp. Cell. Res. 305

      Pages: 266-276

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17510057
  • [Journal Article] Establishment of Ku70-Deficient Lung Epithelial Cell Lines and Their Hypersensitivity to Low-Dose X-Irradiation.

    • Author(s)
      Manabu KOIKE, Yasutomo YUTOKU, Aki KOIKE
    • Journal Title

      Journal of Veterinary Medical Science 14

      Volume: in press

    • NAID

      130000444626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] Detection of double-stranded DNA breaks and apoptosis induced by bleomycin in mouse intestine.2021

    • Author(s)
      Ikuta T, Koike A, Koike M.
    • Organizer
      第44回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K07437
  • [Presentation] ブレオマイシン処理によるマウス腸組織のDNA二本鎖切断とアポトーシス細胞の検出2020

    • Author(s)
      生田統悟、小池亜紀、小池学
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20K07437
  • [Presentation] DNA 修復機構と重粒子線がん治療の高精度化と適応拡大2020

    • Author(s)
      小池学
    • Organizer
      昭和大学学士会後援セミナー
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K12337
  • [Presentation] 重粒子線治療に資する難治性がんのDNA修復能の変化を指標とする基礎研究2019

    • Author(s)
      小池学,大森さくら,湯徳靖友,藤井万紀子
    • Organizer
      平成30年度HIMAC共同利用研究成果発表会
    • Data Source
      KAKENHI-PROJECT-19K12337
  • [Presentation] Acetylation of nuclear localization signal controls importin-mediated nuclear transport of Ku702019

    • Author(s)
      Fujimoto H, Ikuta T, Koike A, Koike M
    • Organizer
      The 16th International Congress of Radiation Research (ICRR2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K12337
  • [Presentation] 組織特異的DNA修復経路欠損マウスの開発-腸管上皮特異的Ku70欠損マウス2019

    • Author(s)
      生田統悟、神田浩明、小池亜紀、小池学
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K11653
  • [Presentation] 重粒子線治療研究に資するDSBセンサー発現抑制細胞株を用いた細胞周期依存的な放射線感受性とDNA二本鎖切断損傷修復2018

    • Author(s)
      湯徳靖友、大森さくら、小池亜紀、小池学
    • Organizer
      アイソトープ・放射線研究発表会
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] 有糸分裂期のDSB誘導性の染色体分配異常へのKuの関与2018

    • Author(s)
      湯徳靖友、小池亜紀、大森さくら、小池学
    • Organizer
      日本分子生物学会
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] 量子生命科学研究に向けたヒトと伴侶動物のDNA修復タンパク質Kuのライブセルイメージング:DSB損傷認識と翻訳後修飾変化2018

    • Author(s)
      小池学
    • Organizer
      生物学・光源・物性研究者による量子生物学勉強会(第2回)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] 計算化学的手法を用いたKu70のアセチル化の効果の解析2017

    • Author(s)
      藤本浩文,生田統悟,小池亜紀,小池学
    • Organizer
      日本放射線影響学会第60回大会
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] 細胞内の「放射線からDNAを守る仕組み」のビジュアル化 ―先端生命科学に基づくキャラクターを活用した教材化の可能性―2017

    • Author(s)
      小池学,湯徳靖友,小池亜紀
    • Organizer
      第54回アイソトープ・放射線研究発表会
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] DNA修復蛋白質Kuに関する研究2017

    • Author(s)
      小池学
    • Organizer
      第2回QSTバイオ研究討論会
    • Data Source
      KAKENHI-PROJECT-16K00554
  • [Presentation] 伴侶動物のDNA二本鎖切断修復の分子機構に基づく新しい放射線増感剤開発の基盤研究―DNA修復蛋白質XRCC4が損傷DNAに集積する様子のライブセルイメージング―2016

    • Author(s)
      小池亜紀、湯徳靖友、小池学
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-26450438
  • [Presentation] ヒトのDNA修復蛋白質が損傷DNAを修復するために損傷部に集積する様子のライブセル イメージング-たった 1 つの遺伝子変異の影響-2013

    • Author(s)
      小池 学、湯徳靖友、小池亜紀
    • Organizer
      第50回 アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24510078
  • [Presentation] ヒトDNA修復蛋白質が損傷DNAを修復するために損傷部に集積する様子の可視化2012

    • Author(s)
      小池 学、湯徳 靖友、小池 亜紀
    • Organizer
      第49回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24510078
  • [Presentation] がん細胞への放射線作用とDNA修復機構2011

    • Author(s)
      小池学
    • Organizer
      昭和大学腫瘍分子研セミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-10-17
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] がん細胞への放射線作用とDNA修復機構2011

    • Author(s)
      小池学
    • Organizer
      昭和大学腫瘍分子研セミナー
    • Place of Presentation
      東京,品川
    • Year and Date
      2011-10-17
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] エックス線照射したマウス個体におけるH2AXリン酸化修飾変化の組織特異性に関する研究2010

    • Author(s)
      菅澤純、湯徳靖友、小池亜紀、小池学
    • Organizer
      第47回アイソトープ・放射線研究発表会
    • Place of Presentation
      日本科学未来館(東京都)
    • Year and Date
      2010-07-09
    • Data Source
      KAKENHI-PROJECT-20510059
  • [Presentation] 計算化学的手法を用いたKuタンパク質とDNAの相互作用部位の構造解析2010

    • Author(s)
      藤本浩文, 樋口真理子, 小池学, Miroslav Pinak, Juraj Kotulic Bunta, 根本俊行, 前川秀彰, 作道隆, 高田直子, 土田耕三
    • Organizer
      BMB2010事務局(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ホトアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] 近紫外線レーザーマイクロ照射によるDNA修復酵素の挙動解析2009

    • Author(s)
      小池学
    • Organizer
      第4回高崎量子応用シンポジウム
    • Place of Presentation
      高崎シティーギャラリー・コアホール
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-20510059
  • [Presentation] Molecular mechanisms of DNA double-strand break recognition process by NHEJ factor Ku in mammalian living cells2009

    • Author(s)
      小池学
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] 近紫外線レーザーマイクロ照射によるDNA修復酵素の挙動解析2009

    • Author(s)
      小池学
    • Organizer
      第4回 高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎シティギャラリー・コアホール
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-20510059
  • [Presentation] Molecular mechanisms of DNA double-strand break recognition process by NHEJ factor Ku in mammalian living cells2009

    • Author(s)
      小池学
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] 近紫外線レーザーマイクロ照射によるDNA修復酵素の挙動解析2009

    • Author(s)
      小池学
    • Organizer
      第4回高崎量子応用研究シンポジウム
    • Place of Presentation
      群馬
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] 近紫外線レーザーマイクロ照射によるDNA修復酵素の挙動解析2009

    • Author(s)
      小池学
    • Organizer
      第4回 高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎シティギャラリー・コアホール(群馬県)
    • Year and Date
      2009-10-09
    • Data Source
      KAKENHI-PROJECT-21510063
  • [Presentation] DNA修復蛋白質XLF/NHEJ1が損傷DNAを修復するために損傷部に集積する様子のライブセルイメージングとDSB認識の分子機構の解明ー人間、家畜、伴侶動物、実験動物ー

    • Author(s)
      小池 亜紀、湯徳 靖友、小池 学
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道大学高等教育推進機構
    • Year and Date
      2014-09-09 – 2014-09-12
    • Data Source
      KAKENHI-PROJECT-26450438
  • [Presentation] ヒトのDNA 修復蛋白質が損傷DNA を修復するために損傷部に集積する様子のライブセルイメージング-患者由来のXLF遺伝子変異の影響̶-

    • Author(s)
      小池 学、湯徳 靖友、小池 亜紀
    • Organizer
      第51回アイソトープ・放射線研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-07 – 2014-07-09
    • Data Source
      KAKENHI-PROJECT-24510078
  • 1.  KOIKE Aki (50415410)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 10 results
  • 2.  IKUTA Togo (00262072)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 3.  FUJIMOTO Hirofumi (60373396)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 4.  Fujii Makiko (70406031)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  SAKUDOH Takashi (70455393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  TSUCHIDA Kozo (40231435)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  KAWAJIRI Kaname (50142112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KOBAYASHI Yasuhito (80425652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  塩見 忠博 (40162573)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  高萩 真彦 (30260235)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  森 雅彦 (30270614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  原田 良信 (90192707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  小藤 昌志 (10375066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  今井 高志 (50183009)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  柿本 直也 (50324794)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  峯 裕一 (60605989)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  Verdonschot RG (30756094)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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