Ling Feng 凌楓

… Alternative Names

LING Feng 凌楓

凌楓リョウフウ

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Researcher Number	70281665
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 特別嘱託研究員
Affiliation (based on the past Project Information) *help	2018 – 2022: 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 2016 – 2017: 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 専任研究員 2015: 国立研究開発法人理化学研究所, 吉田化学遺伝学研究室, 研究員 2008 – 2014: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 専任研究員 2013: 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 研究員 2006 – 2007: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 先任研究員 1996 – 1998: 理化学研究所, 遺伝生化学研究室, 研究員
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 43010:Molecular biology-related / Genome biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator ミトコンドリア / ミトコンドリアDNA / 出芽酵母 / ホモプラスミー / コンカテマー / Saccharomyces cerevisiae / ヘテロプラスミー / ローリングサークル型DNA複製 / 組換え / ミトコンドリアDNAの組換え … More / 活性酸素種 / Concatemer / DNA二本鎖切断 / DNA複製 / 酸化ストレス応答 / ローリングサークル型複製 / 除去修復 / 相同DNA対合 / ストレス / 核酸 / 遺伝子 / 遺伝学 / CCE1遺伝子 / DNA組換え / MHR1遺伝子 / 欠失変異mtDNA / mtDNAの組換え / ミトコンドリアのABCトランスポーター / フリードライヒ運動失調症 / 二本鎖切断 / 酸化ストレス / TCA回路 / 超抑制複製 / アポトーシスの活性化因子 / mhr1-1変異 / mtDNAの組換酵素Mhr1 / 経時寿命 / ヌクレオシド / ホモプラスミー化 / mtDNAコピー数 / mtDNA複製 / ローリングサイクル型 / 二本鎖DNA切断 / 相同組換え酵素 / ミトコンドリアDNA複製・修復・分配 / 活性酸素種(ROS) / 過酸化水素 / ローリングサーク型複製 / mtDNAの欠失変異 / 酸素消費速度 / iPS細胞 / マイトファージの活性化 / ローリングサークル型mtDNA複製 / DNA鎖交換体の形成 / 欠失変異ミトコンドリアDNA / 相同的組換え / 相同的DNA対合 / DNA repair / Heteroplasmv / Homoplasmv / Rolling circle DNA replication / Homologous DNA recombination / DNA double-strand break / DNA修復 / 相同DNA組換え / ５’ー３’エキソヌクレアーゼ / ROSスカンベンジャー / チェック・ポイント活性化 / 細胞周期 / ロ-リングサークル型複製 / DNA損傷修復 / DNA二重鎖切断 / 活性酸素種( / チェックポイント / 品質管理 / Rolling-circle type / zygote / replication / mitochondrial fusion / ミトコンドリアヌクレアーゼ / 呼吸鎖複合体 / Mhr1タンク質 / DNA損傷 / ミトコンドリア融合 / Saccharomvces cerevisias / DNAの組換え / 酵素 / 組換え中間体解離酵素 / 組換え中間体 / DNA結合能 / mhr1-1変異体 / 酵素呼吸阻害剤 / 活性酵素種 / ミトコンドリアDNAの安定維持 / mhr1変異 / 遺伝子変換型組換え … More Except Principal Investigator NMR / DNAトポロジー / SPOl1 / RecA / 相同対合 / Rad51 / RAD52 / 遺伝的組換え / 天然変性タンパク質 / 分子認識 / バイオテクノロジー / Dな / 酵素 / 蛋白質 / RecA型組換え酵素 / 組換え酵素 / 組換えメディエーター / RecA蛋白質 / RecA/Rad51族組換え酵素 / 相同DNA対合 / Rad51 組換え酵素 / Srs2 DNAヘリカーゼ / RecA族組換え酵素 / Rad52 組換えメディエーター / LOH / 体細胞組換え / 相同DNA組換え / 天然変性領域 Less

Study on mechanisms for maintenance of mitochondrial DNA integrityPrincipal Investigator
- Principal Investigator
  
  凌楓
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Institute of Physical and Chemical Research
The studies on the molecular basis of human mitochondrial DNA homoplasmy formationPrincipal Investigator
- Principal Investigator
  
  LING Feng
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
Regulatory mechanism for initiating yeast mitochondrial DNA recombination-driven reolication upon nuclear DNA damagePrincipal Investigator
- Principal Investigator
  
  LING Feng
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Institute of Physical and Chemical Research
A Mechanism for Mitochondrial DNA Copy Number-regulated Simultaneous Expression of Proteins in Respiratory Complexes.Principal Investigator
- Principal Investigator
  
  LING Feng
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  The Institute of Physical and Chemical Research
Functions of intrinsically disordered regions in homologous recombination
- Principal Investigator
  
  SHIBATA Takehiko
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Analysis of Molecular Mechanism for Regulating Initiation of Recombination-mediated Mitochondrial DNA ReplicationPrincipal Investigator
- Principal Investigator
  
  LING Feng
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research
A Novel Regulatory Mechanism for Initiation of Mitochondrial DNA ReplicationPrincipal Investigator
- Principal Investigator
  
  FENG Ling
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research
酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator
- Principal Investigator
  
  凌楓
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The Institute of Physical and Chemical Research
酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator
- Principal Investigator
  
  凌楓
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator
- Principal Investigator
  
  凌楓
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research

[Book] ミトコンドリアダイナミクス(機能から疾患・老化まで)2021
- Author(s)
  凌楓、吉田稔石原直忠ほか82名：
- Total Pages
  458
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860437466
- Data Source
  KAKENHI-PROJECT-20K06498
[Journal Article] Rolling-Circle Replication in Mitochondrial DNA Inheritance: Scientific Evidence and Significance from Yeast to Human Cells2020
- Author(s)
  Feng Ling, Minoru Yoshida
- Journal Title
  
  Genes (Basel)
  
  Volume: 11(5) Issue: 5 Pages: 514-526
- DOI
  10.3390/genes11050514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07294, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-20K06498
[Journal Article] Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr12019
- Author(s)
  Feng Ling, Eliot Bradshaw, Minoru Yoshida
- Journal Title
  
  Scientific Reports
  
  Volume: 9 (1) Issue: 1 Pages: 5433-5445
- DOI
  10.1038/s41598-019-41699-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07294, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204
[Journal Article] Regulation of Small Mitochondrial DNA Replicative Advantage by Ribonucleotide Reductase in Saccharomyces cerevisiae2017
- Author(s)
  Elliot Bradshaw, Minoru Yoshida, *Feng Ling,
- Journal Title
  
  G3 (Bethesda)
  
  Volume: 7 Issue: 9 Pages: 3083-3090
- DOI
  10.1534/g3.117.043851
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07294, KAKENHI-PROJECT-26221204
[Journal Article] ROS stimulate mitochondrial allele segregation towards homoplasmy in human cells2016
- Author(s)
  Feng Ling, Rong Niu, Hideyuki Hatakeyama, Yu-ichi Goto, Takehiko Shibata and Minoru Yoshida
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 27 Issue: 10 Pages: 1-10
- DOI
  10.1091/mbc.e15-10-0690
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440013, KAKENHI-PROJECT-26221204
[Journal Article] Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast2013
- Author(s)
  Feng Ling, Akiko Hori, Ayako Yoshitani, Rong Niu, Minoru Yoshida, and Takehiko Shibata
- Journal Title
  
  Nucleic Acids Research
  
  Pages: 5799-5816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Din7 and Mhr1 expression levels regulate double-strand-break–induced replication and recombination of mtDNA at ori5 in yeast2013
- Author(s)
  Feng Ling, Akiko Hori, Ayako Yoshitani, Rong Niu, Minoru Yoshida and Takehiko Shibata,
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 41 (11) Pages: 5799-5816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Din7 and Mhr1 expression levels regulate double-strand-break-induced replication and recombination of mtDNA at ori5 in yeast2013
- Author(s)
  *Feng Ling, Akiko Hori, Ayako Yoshitani, Rong Niu, Minoru Yoshida and Takehiko Shibata
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 41(8) Issue: 11 Pages: 5799-5816
- DOI
  10.1093/nar/gkt273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Mitochondrial fission proteins Fis1 and Mdv1, but not Dnm1, play a role in maintenance of heteroplasmy in budding yeast2012
- Author(s)
  Elliot Bradshaw, Minoru Yoshida and Feng Ling
- Journal Title
  
  FEBS Letters
  
  Volume: 586(8) Pages: 1245-1251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Increases in Mitochondrial DNA Content and 4977-bp Deletion Upon ATM/Chk2 Checkpoint Activation in HeLa Cells2012
- Author(s)
  Rong Niu, Minoru Yoshida and *Feng Ling
- Journal Title
  
  PLoS ONE
  
  Volume: 7(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Increased 4977-bp deletion in mitochondrial DNA upon ATM/Chk2 checkpoint activation in HeLa cells2012
- Author(s)
  Rong Niu, Minoru Yoshida and Feng Ling
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Enlightenment of yeast mitochondrial homoplasmy : diversified roles of gene conversion2011
- Author(s)
  Feng Ling
- Journal Title
  
  Genes
  
  Volume: 2 Pages: 169-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Gene conversion through double-strand break-induced DNA replication and mitochondrial homoplasmy2011
- Author(s)
  Feng Ling, Tsutomu Mikawa and Takehiko Shibata
- Journal Title
  
  Genes
  
  Volume: 2 Pages: 169-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Mitochondrial fusion increases the mitochondrial DNA copy number in budding yeast2011
- Author(s)
  Akiko Hori, Minoru Yoshida and Feng Ling
- Journal Title
  
  Genes to Cells
  
  Volume: 16 Pages: 527-544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510237
[Journal Article] Enlightenment of yeast mitochondrial homoplasmy : diversified roles of gene conversion2011
- Author(s)
  Ling, F.
- Journal Title
  
  Genes
  
  Volume: 2 Pages: 169-190
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113004
[Journal Article] Enlightenment of yeast mitochondrial homoplasmy : diversified roles of gene conversion2011
- Author(s)
  Ling, F., Mikawa, T. and Shibata, T.
- Journal Title
  
  Genes (Basel)
  
  Volume: 2 Issue: 1 Pages: 169-190
- DOI
  10.3390/genes2010169
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113004, KAKENHI-PROJECT-22570147, KAKENHI-PROJECT-23510237
[Journal Article] Gene conversion through double-strand break-induced DNA replication and mitochondrial homoplasmy2011
- Author(s)
  Feng Ling, Tsutomu Mikawa, Takehiko Shibata
- Journal Title
  
  Genes 2
  
  Pages: 169-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Analysis of DNA-binding sites on Mhr1, a yeast mitochondrial ATP-independent homologous pairing protein2010
- Author(s)
  Tokiha Masuda, Feng Ling, Takehiko Shibata, Tsutomu Mikawa
- Journal Title
  
  FEBS Journal 277
  
  Pages: 1440-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Analysis of DNA-binding sites on Mhr1, a yeast mitochondrial ATP-independent homologous pairing protein2010
- Author(s)
  Masuda, T., Ling, F., Shibata, T. and Mikawa, T.
- Journal Title
  
  FEBS J.
  
  Volume: 277 Pages: 1440-1452
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113004
[Journal Article] Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase2009
- Author(s)
  Feng Ling
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 9341-9353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Negative supercoil interference with homologous pairing mediated by Mhr1, an ATP-independent recombinase structurally unrelated to RecA/Rad512009
- Author(s)
  Feng Ling, Minoru Yoshida, Takehiko Shibata
- Journal Title
  
  The Journal of Biological Chemistry 284
  
  Pages: 9341-9353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase2009
- Author(s)
  Ling, F.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 9341-9353
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113004
[Journal Article] Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase2009
- Author(s)
  Feng Ling
- Journal Title
  
  Journal of Biological Chemistry 284(印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Reactive oxygen species contribute to recombination-mediated replication to regulate the mitochondrial DNA copy number2009
- Author(s)
  Akiko Hori, Minoru Yoshida, Takehiko Shibata, Feng Ling
- Journal Title
  
  Nucleic Acids Research 37
  
  Pages: 749-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase2009
- Author(s)
  Ling, F., Yoshida, M. and Shibata, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 Pages: 9341-9353
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21113004
[Journal Article] A novel cis-acting element required for DNA damage-inducible expression of yeast DIN72008
- Author(s)
  Ayako Yoshitani, Minoru Yoshida, and Feng Ling,
- Journal Title
  
  Bioehemical and Biophysical Research Communication 365
  
  Pages: 183-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] A novel cis-acting element required for DNA damage-inducible expression of yeast DIN7.2008
- Author(s)
  Ayako Yoshitani, Minoru Yoshida, Feng Ling
- Journal Title
  
  Biochemical and Biophysical Research Communications 365(1)
  
  Pages: 183-188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] The yeast checkpoint kinase Dun1 down-regulates DIN7 in the absence of DNA damage2008
- Author(s)
  Ayako Yoshitani, Feng Ling, Minoru Yoshida
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry 72(6)
  
  Pages: 1630-1634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570171
[Journal Article] A novel cis-acting element required for DNA damage-inducilble experession of yeast DIN72008
- Author(s)
  Ayako Yoshitani, Minoru Yoshida, Feng Ling
- Journal Title
  
  Biochemical and Biophysical Research Communication 365
  
  Pages: 183-188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA recombination-Initiation plays a role in the extremely biased inheritance of yeast[rho] mitochondrial DNA that contains the replication origin ori52007
- Author(s)
  Feng Ling, Akiko Hore, Takehiko Shibata
- Journal Title
  
  Molecular and Cellular Biology 27
  
  Pages: 1133-1145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA Recombination-Initiation Plays a Role in the Extremely Biased Inheritance of Yeast[rho-]Mitochondrial DNA That Contains the Replication Origin ori52007
- Author(s)
  Feng Ling, Akiko Hori, and Takehiko Shibata
- Journal Title
  
  MOLECULAR AND CELLULAR BIOLOGY 27
  
  Pages: 1133-1145
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA recombination-Initiation plays a role in the extremely biased inheritance of yeast [rho] mitochondrial DNA that contains the replication origin ori52007
- Author(s)
  Feng Ling, Akiko Hori, and Takehiko Shibata
- Journal Title
  
  Moleeular and cellular biology 27
  
  Pages: 1133-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA recombination protein-dependent mechanism of homoplasmy and its proposed functions2007
- Author(s)
  Takehiko Shibata, Feng Ling
- Journal Title
  
  Mitochondrion 7
  
  Pages: 17-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA recombination protein-dependent mechanism of homoplasmy and its proposed functions2007
- Author(s)
  Takehiko Shibata and Feng Ling,
- Journal Title
  
  Mitochondrion 7
  
  Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] ローリングサークル型DNA複製:ミトコンドリアDNAコピー数制御機構の新しい普遍的モデル2007
- Author(s)
  凌楓
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 886-892
- NAID
  40015530565
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] a universal model for controlling mechanisms of mitochondrial DNA copy number2007
- Author(s)
  Feng Ling, Akiko Hori, Minoru Yoshida, Takehiko Shibata Rolling circle replication
- Journal Title
  
  Tanpakushitsu Kakusan Koso 52(8)
  
  Pages: 886-92
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] DNA recombination-Initiation plays a role in the extremely biased inheritance of yeast [rho^-] mitochondrial DNA that contains the replication origin ori52007
- Author(s)
  Feng Ling
- Journal Title
  
  Molecular and Cellular Biology 27
  
  Pages: 1133-1145
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570168
[Journal Article] ローリングサークル型DNA複製:ミトコンドリアDNAコピー数制御機構の新しい普遍的モデル2007
- Author(s)
  凌楓、堀晶子、吉田稔、柴田武彦
- Journal Title
  
  蛋白質核酸酵素 52
  
  Pages: 886-892
- NAID
  40015530565
- Data Source
  KAKENHI-PROJECT-18570168
[Patent] ヘテロプラスミー細胞をホモプラスミー化する方法2009
- Inventor(s)
  凌楓、柴田武彦、牛栄、吉田稔、後藤雄一
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-285729
- Filing Date
  2009-12-16
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] Major apurine/apyrimidinic endonuclease Apn1 plays a rol in the highly biased inheritance of yeast[rho-] mitochondrial DNA in budding yeast2021
- Author(s)
  凌楓、朱文娟、吉田稔
- Organizer
  FY2021 CSRS interim Progress ReportMeeting
- Data Source
  KAKENHI-PROJECT-20K06498
[Presentation] ミトコンドリアDNA遺伝の新機構と応用の可能性2021
- Author(s)
  凌楓
- Organizer
  令和3年度第二回名古屋産学官・医連携研究会（名古屋連携研究会： NJK）
- Invited
- Data Source
  KAKENHI-PROJECT-20K06498
[Presentation] eIF5A ハイプシン化阻害剤 GC7 によるミトコンドリア制御2020
- Author(s)
  松本健、黒川留美、凌楓、鈴木健裕、堂前直、吉田稔
- Organizer
  日本ポリアミン学会年会
- Data Source
  KAKENHI-PROJECT-17K07294
[Presentation] A new paradigm of eukaryotic mitochondrial genetic inheritance revealed from studies on yeast mitochondrial DNA replication2020
- Author(s)
  ◯ Ling Feng, Yoshida Minoru
- Organizer
  第４３回日本分子生物学会年会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07294
[Presentation] A new paradigm of eukaryotic mitochondrial genetic inheritance revealed from studies on yeast mitochondrial DNA replication2020
- Author(s)
  ◯Ling Feng, Yoshida Minoru
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06498
[Presentation] The mitochondrial recombinase Mhr1 sustains yeast chronological life span2019
- Author(s)
  Feng Ling、Minoru Yoshida
- Organizer
  国立研究開発法人理化学研究所環境資源科学研究センターの中間発表
- Data Source
  KAKENHI-PROJECT-17K07294
[Presentation] Effects of GC7, a potent inhibitor of eIF5A hypusination, on mitochondrial proteins2019
- Author(s)
  松本　健、黒川留美、Mohammad Tariq、Tilman Schneider-Poetsch、凌　楓、室井誠、鈴木健裕、堂前　直、伊藤昭博、長田裕之、吉田　稔
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K07294
[Presentation] Mitochondral DNA recombination is critical for sustaining yeast chronological lifespan2018
- Author(s)
  Feng LING
- Organizer
  Annual Meeting of Aging project 2018
- Data Source
  KAKENHI-PROJECT-17K07294
[Presentation] A mechanism for oxidative stress-stimulated mitochondrial DNA homoplasmy2016
- Author(s)
  Feng LING, Rong Niu, T. Shibata, Y. Goto, Hatakeyama, H., and M. Yoshida
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440013
[Presentation] A novel mechanism for human mitochondrial allele segregation towards homoplasmy2016
- Author(s)
  Feng LING
- Organizer
  Global Conference of Chinese Geneticists
- Place of Presentation
  Zhejiang University, Hangzhou, Zhejiang Province, China
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-26440013
[Presentation] DNA組換えに立脚したミトコンドリア遺伝の仕組みに関する研究2015
- Author(s)
  凌楓
- Organizer
  柴田武彦先生古稀記念シンポジウム
- Place of Presentation
  早稲田大学大隈会館
- Year and Date
  2015-03-07
- Data Source
  KAKENHI-PROJECT-26440013
[Presentation] 健全な iPS 細胞樹立に向けたミトコンドリア病患者細胞の mtDNA ホモプラスミー化促進法の開発2014
- Author(s)
  凌楓、牛栄、柴田武彦、吉田稔、畠山英之、後藤雄一
- Organizer
  CREST/さきがけ/JST-CIRM 合同シンポジウム
- Place of Presentation
  東京都江東区青海2-3-6 日本科学未来館
- Year and Date
  2014-01-15
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] Role of Recombination-mediated Replication in Mitochondrial Inheritance2012
- Author(s)
  Feng Ling
- Organizer
  The Glycobiology Forum at Jiang Nan University
- Place of Presentation
  School of Biotechnology, Jiangnan University, No. 188800 Lihu Avenue, Wuxi, Jiangsu, P. C. 214122, China
- Year and Date
  2012-07-10
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] A Novel Mechanism for Mitochondrial Inheritance & Its Biomedical Importance2012
- Author(s)
  Feng Ling
- Organizer
  Symposium of Mitochondral Biomedicine
- Place of Presentation
  Zhejiang University in Hangzhou, Zhejiang Province, China
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] Recombination-mediated Replication in Mitochondrial DNA Inheritance2012
- Author(s)
  Feng Ling, Rong Niu, Eliot Bradshaw, Minoru Yoshida
- Organizer
  Global Conference of Chinese Geneticists
- Place of Presentation
  Zhejiang University in Hangzhou, Zhejiang Province, China
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] A Novel Mechanism for Mitochondrial DNA Inheritance and its Medical Significance2012
- Author(s)
  Feng Ling
- Organizer
  Mitochondrial Genetics Forum at Peking University
- Place of Presentation
  Peking University First Hospital, Xi-shi-ku St, Beijing 100034, China
- Year and Date
  2012-08-29
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] Recombination-mediated Replication in Mitochondrial DNA Inheritance2012
- Author(s)
  ○Feng Ling, Rong Niu, Eliot Bradshaw, Minoru Yoshida
- Organizer
  Global Conference of Chinese Geneticists,
- Place of Presentation
  Zhejiang University in Hangzhou, Zhejiang Province, China
- Invited
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] Mitochondrial DNA homoplasmy as gene homogenization of repeated sequences by rolling circle replication.2011
- Author(s)
  Feng Ling, Rong Niu, Elliot Bradshaw, Takehiko Shibata, Minoru Yoshida
- Organizer
  RIKEN Joint Retreat 2011
- Place of Presentation
  Yamaha Resort Tsumagi, Kakegawa, Shizuoka
- Year and Date
  2011-01-31
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] Mitochondrial DNA homoplasmy as gene homogenization of repeated sequences by rolling circle replication.2011
- Author(s)
  Takehiko Shibata, Feng Ling, Tsutomu Mikawa
- Organizer
  The 7th conference of Asian Societyfor mitochondrial research and Medicine and 10th Japanese Society for mitochondrial research and Medicine
- Place of Presentation
  Fukuoka city
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] A Molecular Mechanism for Mitochondrial DNA Homoplasmy and its Application2011
- Author(s)
  Feng Ling
- Organizer
  RIKEN Joint Retreat 2011
- Place of Presentation
  Yamaha Resort Tsumagi, Kakegawa, Shizuoka
- Year and Date
  2011-01-31
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] 相同組換え開始制御に働く天然変性タンパク質の機能2010
- Author(s)
  柴田武彦, 新井直人, 香川亘, 胡桃坂仁志, 増田ときは, 美川務, 新宮良宣, 堀晶子, 凌楓
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌日本
- Data Source
  KAKENHI-PLANNED-21113004
[Presentation] Mitochondrial DNA homoplasmy as gene homogenization of repeated sequences by rolling circle replication2010
- Author(s)
  Shibata, T., Ling, F. and Mikawa, T.
- Organizer
  7th Conference of Asian Society for Mitochondrial Research and Medicine(ASMRM) and 10th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
- Place of Presentation
  Fukuoka, Japan
- Data Source
  KAKENHI-PLANNED-21113004
[Presentation] ROSで誘導される組換え依存型ミトコンドリアDNA複製2009
- Author(s)
  凌楓、堀晶子,牛栄、柴田武彦、吉田稔
- Organizer
  第9回日本ミトコンドリア学会年会
- Place of Presentation
  東京大学医学部鉄門記念講堂
- Year and Date
  2009-12-17
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] ミトコンドリアDNAコピー数を増加させるミトコンドリア融合2009
- Author(s)
  堀晶子、吉田稔、凌楓
- Organizer
  第32回日本分子生物学年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] DNAの位相幾何学的変化を伴わない組換え中間体形成2008
- Author(s)
  柴田武彦、凌楓
- Organizer
  第26回染色体ワークショップ
- Place of Presentation
  姫路
- Year and Date
  2008-01-16
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] 酵母ミトコンドリアDNA複製開始点での二重鎖切断修復に働く相同DNA対合酵素Mhr12008
- Author(s)
  凌楓、堀晶子、柴田武彦、吉田稔
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] ミトコンドリアの相同組換え酵素反応へのDNAの高次構造の効果2008
- Author(s)
  凌楓
- Organizer
  第8回日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] ミトコンドリアの相同組換え酵素反応へのDNAの高次構造の効果2008
- Author(s)
  凌楓、吉田稔、柴田武彦
- Organizer
  第8回日本ミトコンドリア学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] ミトコンドリアゲノムの遺伝的均一化におけるDNA損傷応答因子Din7の役割2007
- Author(s)
  凌楓、柴田武彦、堀晶子、吉田稔
- Organizer
  バイオアーキテクトシンポジウム
- Place of Presentation
  独立行政法人理化学研究所和光研究所鈴木梅太郎記念ホール
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] A role of DNA damage-inducible protein, Din7 in recombination-mediated mitochondrial DNA replication2007
- Author(s)
  Feng Ling, Akiko Hori, Minoru Yoshida and Takehiko Shibata
- Organizer
  FASEB Summer Research Conference on Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Snowmass Village, Colorado, USA
- Year and Date
  2007-07-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] A role of DNA damage-inducible protein,Din7 in recombination-mediated mitochondrial DNA replication2007
- Author(s)
  Feng Ling, Akiko Hori, Minoru Yoshida and Takehiko Shibata
- Organizer
  FASEB Summer Research Conference on Genetic Recombination & Genome Rearrangements
- Place of Presentation
  Snowmass Village,Colorado,USA
- Year and Date
  2007-07-29
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] An accelerated increases of mtDNA copy number by reactive oxygen species and its possible mechanism2007
- Author(s)
  Akiko Hori, Feng Ling, Takehiko Shibata, Minoru Yoshida
- Organizer
  Biochemistry and Molecular Biology, Yokohama(Pacifico Yakohama, InterContinental Yokohama Grand)
- Place of Presentation
  Japan
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] The promoting mechanism of mtDNA copy number in hydrogen peroxide-treated isolated mitochondria2007
- Author(s)
  Akiko Hori, Feng Ling, Takehiko Shibata, Minoru Yoshida
- Organizer
  The 7th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine(J-mit)
- Place of Presentation
  Kagoshima, Japan
- Year and Date
  2007-12-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] ミトコンドリアゲノムの遺伝的均一化におけるDNA損傷応答因子Din7の役割2007
- Author(s)
  堀晶子、凌楓、柴田武彦、吉田稔
- Organizer
  ミトコンドリア学会第7回年会
- Place of Presentation
  南日本新聞社南ホール鹿児島
- Year and Date
  2007-12-20
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] A role of DNA damage-responding protein, Din7 in the establishment of mitochondrial homoplasmy2007
- Author(s)
  Feng Ling, Takehiko Shibata, Akiko Hori, Minoru Yoshida
- Organizer
  Bioarchitect symposium RIKEN(Umetaro Memorial Hall)
- Place of Presentation
  Japan
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] A role of DNA damage-inducible protein, Din7 in recombination・mediated mitochondrial DNA replication2007
- Author(s)
  Feng Ling, Akiko Hori, Minoru Yoshida, Takehiko Shibata
- Organizer
  FASEB Summer Research Conference on Genetic Recombination&Genome Rearrangements
- Place of Presentation
  Snowmas Village, Colorado, USA
- Year and Date
  2007-07-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] 活性酸素種に夜mtDNAコピー数増加とその可能なメカニズム2007
- Author(s)
  堀晶子、凌楓、柴田武彦、吉田稔
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会年会合同大会
- Place of Presentation
  パシフィコ横浜ヨコハマグランドインターコンチネンタルホテル
- Year and Date
  2007-12-04
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] ミトコンドリアのエキソヌクレアーゼによる不安定化からゲノムを守る出芽酵母の相同DNA対合酵素Mhr12007
- Author(s)
  凌楓、柴田武彦、堀晶子、吉田稔
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会年会合同大会
- Place of Presentation
  パシフィコ横浜ヨコハマグランドインターコンチネンタルホテル
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] 活性酸素種によるmtDNAコピー数増加とその可能なメカニズム2007
- Author(s)
  堀晶子、凌楓、柴田武彦、吉田稔
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会年会合同大会
- Place of Presentation
  パシフィコ横浜ヨコハマグランドインターコンチネンタルホテル
- Year and Date
  2007-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] 単離ミトコンドリア解析で明されたROSによるmtDNAコピー数制御機構2007
- Author(s)
  堀晶子、凌楓、柴田武彦、吉田稔
- Organizer
  ミトコンドリア学会第7回年会
- Place of Presentation
  南日本新聞社南ホール鹿児島
- Year and Date
  2007-12-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] A homologous DNA pairing-promoting Mhrlp functions to prevent mtDNA instability caused by overproducing Din7p, an exo-Dnase in yeast2007
- Author(s)
  Feng Ling, Takehiko Shibata, Akiko Hori, Minoru Yoshida
- Organizer
  Biochemistry and Molecular Biology, Yokohama(Pacifico Yakohama, InterContinental Yokohama Grand)
- Place of Presentation
  Japan
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18570168
[Presentation] 健全なiPS細胞樹立に向けたミトコンドリア病患者細胞のmtDNAホモプラスミー化促進法の開発
- Author(s)
  凌楓、牛栄、柴田武彦、吉田稔、畠山英之、後藤雄一
- Organizer
  CREST/さきがけ/JST-CIRM 合同シンポジウム
- Place of Presentation
  東京都江東区青海2-3-6 日本科学未来館
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] 出芽酵母のミトコンドリアDNAの複製開始領域に起きる二重鎖切断導入機構
- Author(s)
  堀晶子、柴田武彦、吉田稔、凌楓
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)
- Data Source
  KAKENHI-PROJECT-20570171
[Presentation] Role of Recombination-mediated Replication in Mitochondrial Inheritance
- Author(s)
  Feng Ling
- Organizer
  The Glycobiology Forum at Jiang Nan University, School of Biotechnology, Jiangnan University,
- Place of Presentation
  No. 188800 Lihu Avenue, Wuxi, Jiangsu, P.C. 214122, China
- Invited
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] A Novel Mechanism for Mitochondrial DNA Inheritance and its Medical Significanc
- Author(s)
  Feng Ling
- Organizer
  Mitochondrial Genetics Forum at Peking University
- Place of Presentation
  Peking University First Hospital, Xi-shi-ku St, Beijing 100034, China
- Invited
- Data Source
  KAKENHI-PROJECT-23510237
[Presentation] 健全なiPS細胞樹立に向けたミトコンドリア病患者細胞のmtDNAホモプラスミー化機構の解析
- Author(s)
  凌楓、牛栄、小林大貴、吉田稔、畠山英之、後藤雄一
- Organizer
  CREST ｢iPS細胞｣領域　研究領域ミーティング
- Place of Presentation
  兵庫県立淡路夢舞台国際会議場
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-26440013

1. INOUE Jin (10469893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SHIBATA Takehiko (70087550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. KUSANO Kohji (70336098)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ARAI Naoto (70297795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KAGAWA Wataru (70415123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KIKAWA Tsutomu (20321820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Ling Feng 凌 楓

LING Feng 凌 楓

凌 楓 リョウ フウ

Research Projects

Research Products

Co-Researchers

Study on mechanisms for maintenance of mitochondrial DNA integrityPrincipal Investigator

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The studies on the molecular basis of human mitochondrial DNA homoplasmy formationPrincipal Investigator

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Regulatory mechanism for initiating yeast mitochondrial DNA recombination-driven reolication upon nuclear DNA damagePrincipal Investigator

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A Mechanism for Mitochondrial DNA Copy Number-regulated Simultaneous Expression of Proteins in Respiratory Complexes.Principal Investigator

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Functions of intrinsically disordered regions in homologous recombination

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Analysis of Molecular Mechanism for Regulating Initiation of Recombination-mediated Mitochondrial DNA ReplicationPrincipal Investigator

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A Novel Regulatory Mechanism for Initiation of Mitochondrial DNA ReplicationPrincipal Investigator

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酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator

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酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator

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酵母ミトコンドリアDNAの相同的組換えの機能と制御に関する研究Principal Investigator

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[Book] ミトコンドリアダイナミクス(機能から疾患・老化まで)2021

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[Journal Article] Rolling-Circle Replication in Mitochondrial DNA Inheritance: Scientific Evidence and Significance from Yeast to Human Cells2020

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[Journal Article] Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr12019

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[Journal Article] Regulation of Small Mitochondrial DNA Replicative Advantage by Ribonucleotide Reductase in Saccharomyces cerevisiae2017

Ling Feng 凌楓

LING Feng 凌楓

凌楓リョウフウ