Isobe Takeshi 礒部威

… Alternative Names

ISOBE Takeshi 礒部威

磯部威イソベタケシ

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Researcher Number	70284198
Other IDs
External Links
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 教授
Affiliation (based on the past Project Information) *help	2024: 島根大学, 学術研究院医学・看護学系, 教授 2018 – 2019: 島根大学, 学術研究院医学・看護学系, 教授 2010 – 2017: 島根大学, 医学部, 教授 1997 – 2000: 広島大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / 応用薬理学・医療系薬学 Except Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related / Respiratory organ internal medicine
Keywords	Principal Investigator 肺癌 / 塩酸イリノテカン / 小細胞肺癌 / 血管新生抑制 / ヌードマウス / 薬剤耐性 / 血管新生 / 小細胞癌 / 非閉塞性肺疾患癌 / 個別化治療 … More / 呼吸器感染症 / 肺線維症 / 非閉塞性肺疾患 / 薬動力学 / 薬物動態 / 血小板減少 / トロンボポエチン / カルボプラチン … More Except Principal Investigator 化学療法 / chemotherapy / p53 / alternative splicing / hTERT / 腫瘍循環器 / 血栓塞栓症 / 肺がん / SIRT / NAMPT / 癌 / 臨床試験 / 好中球減少 / neutropenia / prognosis / cytology / telomerase / lung cancer / 遺伝子変異 / 遺伝子 / 予後 / 細胞診 / テロメラーゼ / 肺癌 / 感染実験 / ジェノタイプ / マウスモデル / 免疫補助療法 / 漢方薬 / 非結核性抗酸菌 Less

肺がん患者の血栓塞栓症発症のリスク評価ツール確立とVTE発症メカニズム解明の研究
- Principal Investigator
  
  津端由佳里
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shimane University
A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy
- Principal Investigator
  
  Tsubata Yukari
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Shimane University
New therapeutic strategy for small-cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Isobe Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Shimane University
Proteomic analysis and genotyping of nontuberculosis mycobacteria to investigate effects of traditional Chinese medicines against pathogenesis
- Principal Investigator
  
  SANO Chiaki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Shimane University
Personalized cancer medicine for non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  ISOBE Takeshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Shimane University
Study on the relaationship between telomerase activity or genetic aberrations and response to chemotherapy in lung cancer
- Principal Investigator
  
  HIYAMA Keiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HIROSHIMA UNIVERSITY
カルボプラチンの薬物動態モニタリングによる血清トロンボポエチン活性変動の予測Principal Investigator
- Principal Investigator
  
  磯部威
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Hiroshima University

All 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Up-regulated integrinα4β1 on systemic lymphocytes and serum IL-17A in interstitial pneumonia2016
- Author(s)
  Taooka Y, Ohe M, Tada M, Sutani A, Isobe T
- Journal Title
  
  Clin Respir J.
  
  Volume: 10(6) Issue: 6 Pages: 722-730
- DOI
  10.1111/crj.12277
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461159
[Journal Article] The A allele at rs13419896 of EPAS1 is associated with enhanced expression and poor prognosis for non-small cell lung cancer.2015
- Author(s)
  Andika C. Putra, Hidetaka Eguchi, Kian Leong Lee, Yuko Yamane, Ewita Gustine, Takeshi Isobe, Masahiko Nishiyama, Keiko Hiyama, Lorenz Poellinger, Keiji Tanimoto*.
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 8 Pages: 0134496-0134496
- DOI
  10.1371/journal.pone.0134496
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11252, KAKENHI-PROJECT-25461159, KAKENHI-PROJECT-221S0001
[Journal Article] Nephrotoxicity induced by piperacillin-tazobactam in late elderly Japanese patients with nursing and healthcare associated pneumonia2014
- Author(s)
  Karino F, Nishimura N, Ishihara N, Moriyama H, Miura K, Hamaguchi S, Sutani A, Kuraki T, Ikawa K, Morikawa N, Naora K, Isobe T
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 37 Pages: 1971-1976
- NAID
  130004693807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461159
[Journal Article] Multiple logistic regression analysis of risk factors in elderly pneumonia patients: QTc interval prolongation as a prognostic factor2014
- Author(s)
  Taooka Y, Takezawa G, Ohe M, Sutani A, Isobe T
- Journal Title
  
  Multidiscip Respir Med
  
  Volume: 9 Issue: 1 Pages: 1-6
- DOI
  10.1186/2049-6958-9-59
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461159
[Journal Article] Comparative analysis of a complement fixation assay and enzyme immunoassay to determine the seroprevalence of measles and varicella in a survey of healthcare workers2013
- Author(s)
  Shibata H, Kumakura S, Isobe T, Hirose M, Ohe M, Nishimura N, Onoda K, Nagai A, Yamaguchi S
- Journal Title
  
  J Int Med Res
  
  Volume: 41 Pages: 224-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] 難治性Mycobacterium abscessus complex症例分離菌のマウスモデルを用いた基礎的検討2017
- Author(s)
  佐野千晶，多田納豊，森　雄亮，堀田尚誠，津端由佳里，濱口　愛，濱口俊一，竹山博泰，礒部　威，冨岡治明
- Organizer
  第92回日本結核病学会総会
- Place of Presentation
  東京・東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] 非結核性抗酸菌症の増悪に関わる宿主因子についての研究．2016
- Author(s)
  佐野千晶，多田納豊，森　雄亮，堀田尚誠，津端由佳里，濱口俊一，濱口愛，沖本民生，竹山博泰，冨岡治明，礒部威
- Organizer
  第10回日本結核病学会中国四国支部研究会
- Place of Presentation
  岡山・ダイワロイネットホテル岡山駅前
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] 新規感染方法による非結核性抗酸菌症マウスモデルについての検討2016
- Author(s)
  佐野千晶，多田納豊，沖本民生，堀田尚誠，濱口俊一，竹山博泰，冨岡治明，礒部威
- Organizer
  第91回日本結核病学会総会
- Place of Presentation
  金沢市・ホテル日航金沢
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Establishment of the Novel Mouse Models of Human Lung Nontuberculous Mycobacterial Infections2016
- Author(s)
  T. Isobe, C. Sano, R.Tanino, Y. Tatano, Y. Mori, M. Nakao,Y. Amano, T. Hotta, M. Hamaguchi, T. Okimoto,Y. Tsubata, S. Hamaguchi, H. Takeyama
- Organizer
  American Thoracic Society 2016 International Conference
- Place of Presentation
  The Moscone Center，San Francisco USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] 非結核性抗酸菌症増悪に関与する宿主因子についての基礎的研究2015
- Author(s)
  佐野千晶，多田納豊，金廣優一，吉山裕規，濱口愛，沖本民生，津端由佳里，三浦聖高，星野鉄兵，濱口俊一，須谷顕尚，竹山博泰，久良木隆繁，冨岡治明，礒部　威
- Organizer
  第9回日本結核病学会中国四国支部研究会
- Place of Presentation
  岡山・岡山コンベンションセンター
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Mycobacterium avium complex (MAC)増殖に関する宿主要因についての成績ならびに中国四国支部会MAC症宿主要因解明プロジェクトのお願い2014
- Author(s)
  佐野千晶，多田納豊，金廣優一，冨岡治明，吉山裕規，濱口愛，沖本民生，津端由佳里，三浦聖高，大江美紀，須谷顕尚，竹山博泰，久良木隆繁，礒部威
- Organizer
  第8回日本結核病学会中国四国支部研究会
- Place of Presentation
  岡山・ダイワロイネットホテル岡山駅前
- Year and Date
  2014-09-13
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Mycobacterium avium complex 症患者における血清抗Glycopeptidolipid core IgA 抗体の時間的変動に関する検討2014
- Author(s)
  三浦聖高，谷野良輔，木庭尚哉，堀田尚誠，沖本民生，津端由佳里，濱口俊一，大江美紀，須谷顕尚，竹山博康，粟屋幸一，久良木隆繁，廣瀬昌博，礒部威
- Organizer
  第64回日本結核病学会中国四国支部会
- Place of Presentation
  岡山市・岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] 肺抗酸菌症を疑い気管支鏡検査を施行した症例の検討2013
- Author(s)
  三浦聖高，須谷顕尚，木庭尚哉，沖本民生，津端由佳里，濱口俊一，本田健，大江美紀，久良木隆繁，竹山博泰，廣瀬晶博，礒部威
- Organizer
  第36回日本呼吸器内視鏡学会学術集会
- Place of Presentation
  さいたま市・大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Phase I/II and pharmacological clinical study of combination chemotherapy with irinotecan and erlotinib for recurrent lung cancer2013
- Author(s)
  Okimoto T, Hotta T, Koba N, NishikawaE, Maehara M, Miura K, Karino F, Iwamoto S, Tsubata Y, Hamaguchi S, Honda T, Mitsuhiro T, Ohe M, Sutani A, Kuraki T,Takeyama H, M, Hamada A, Isobe T
- Organizer
  Aamerican Thoracic Society
- Place of Presentation
  Philadelphia(米国)
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] Phase I/II And Pharmacological Clinical Study Of Combination Chemotherapy With Irinotecan And Erlotinib For Recurrent Lung Cancer2013
- Author(s)
  Okimoto T, Isobe T
- Organizer
  American Thoracic Society
- Place of Presentation
  Philadelphia（米国）
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] 当院における喀痰抗酸菌陽性症患者の臨床的検討2013
- Author(s)
  三浦聖高，多田光宏，本田健，大江美紀，須谷顕尚，久良木隆繁，竹山博泰，森山英彦，廣瀬晶博，礒部威
- Organizer
  第53回日本呼吸器学会学術講演会
- Place of Presentation
  東京・東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Effect of erlotinib on the pharmacokinetics of irinotecan and its metabolites in an animal model: a drug-drug interaction study2013
- Author(s)
  Sanematsu E, Isobe T
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Washington（米国）
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] Evaluation of novel orthotopic nude mouse models for human small cell lung cancer2012
- Author(s)
  Isobe T , Nishio Y, Fuchita H, Koba N,Nishikawa E, Hotta T, Okimoto T, Iwamoto S, Karino F, Tsubata Y, Miura K, Tada M, Suzuki T, Honda T, Hamaguchi S, Hanada M, Ohe M, Sutani A, Kuraki T, Takeyama H, Onn A, Roy S. Herbst
- Organizer
  Japanese Cancer Society
- Place of Presentation
  Royton Sapporo(北海道)
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] Comparison of biomarker expression between biopsy and surgical specimens of non-small-cell lung cancer. Assessement by immunohistochemical staining.2012
- Author(s)
  Okimoto T, Tsubata Y, Sutani A, Fuchita H, Koba N, Nishikawa E, Hotta T, Okimoto T, Iwamoto S, Karino F, Miura K, Tada M, Suzuki T, Honda T, Hamaguchi S, Ohe M, Sutani A, Kuraki T, Isobe T
- Organizer
  American Thoracic Sosiety
- Place of Presentation
  SanFrancisco(米国)
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] Comparison of biomarker expression between biopsy and surgical specimens of non-small-cell lung cancer.　Assessement by immunohistochemical staining.2012
- Author(s)
  Okimoto, Isobe T
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco（米国）
- Data Source
  KAKENHI-PROJECT-22590864
[Presentation] 気管支鏡による抗酸菌検査と血清抗 Glycopeptidolipid core IgA 抗体についての検討
- Author(s)
  三浦聖高，木庭尚哉，堀田尚誠，谷野良輔，沖本民生，前原　愛，津端由佳里，濱口俊一，大江美紀，須谷顕尚，久良木隆繁，竹山博康，粟屋幸一，廣瀬昌博，礒部　威
- Organizer
  第89回日本結核病学会総会
- Place of Presentation
  岐阜・長良川国際会議場
- Year and Date
  2014-05-09 – 2014-05-10
- Data Source
  KAKENHI-PROJECT-25461159
[Presentation] Comparison Of Clinical And Radiographic Characteristics Between Nontuberculous Mycobacterial Lung Disease And Pulmonary Tuberculosis
- Author(s)
  K. Miura, N. Koba, T. Hotta, R. Tanino, M. Hamaguchi, T. Okimoto, Y. Tsubata, S. Hamaguchi, M. Ohe, A. Sutani, H. Takeyama, Y. Awaya, H. Moriyama, M. Hirose, T. Kuraki, T. Isobe
- Organizer
  ATS 2014 international conference
- Place of Presentation
  San Diego Convention Center, USA
- Year and Date
  2014-05-16 – 2014-05-21
- Data Source
  KAKENHI-PROJECT-25461159
[]

1. Tsubata Yukari (50643417)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SANO Chiaki (70325059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. HIYAMA Keiko (60253069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ISHIOKA Shinichi (10191868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 多田納豊 (70432614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 金廣優一 (60609197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 三浦聖高 (90646986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. 冨岡治明 (40034045)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 吉山裕規 (10253147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 須谷顕尚 (80306290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 沖本民生 (00733586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 濱口俊一 (70609354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 堀口道子 (70632470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 斉藤光江 (30205679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 山下親正 (30622188)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TANINO Ryosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. 谷本圭司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isobe Takeshi 礒部 威

ISOBE Takeshi 礒部 威

磯部 威 イソベ タケシ

Research Projects

Research Products

Co-Researchers

肺がん患者の血栓塞栓症発症のリスク評価ツール確立とVTE発症メカニズム解明の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New therapeutic strategy for small-cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteomic analysis and genotyping of nontuberculosis mycobacteria to investigate effects of traditional Chinese medicines against pathogenesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Personalized cancer medicine for non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the relaationship between telomerase activity or genetic aberrations and response to chemotherapy in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カルボプラチンの薬物動態モニタリングによる血清トロンボポエチン活性変動の予測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Up-regulated integrinα4β1 on systemic lymphocytes and serum IL-17A in interstitial pneumonia2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The A allele at rs13419896 of EPAS1 is associated with enhanced expression and poor prognosis for non-small cell lung cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nephrotoxicity induced by piperacillin-tazobactam in late elderly Japanese patients with nursing and healthcare associated pneumonia2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Multiple logistic regression analysis of risk factors in elderly pneumonia patients: QTc interval prolongation as a prognostic factor2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative analysis of a complement fixation assay and enzyme immunoassay to determine the seroprevalence of measles and varicella in a survey of healthcare workers2013

Author(s)

Journal Title

Data Source

[Presentation] 難治性Mycobacterium abscessus complex症例分離菌のマウスモデルを用いた基礎的検討2017

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 非結核性抗酸菌症の増悪に関わる宿主因子についての研究．2016

Author(s)

Organizer

Isobe Takeshi 礒部威

ISOBE Takeshi 礒部威

磯部威イソベタケシ

[Presentation] Comparison of biomarker expression between biopsy and surgical specimens of non-small-cell lung cancer.　Assessement by immunohistochemical staining.2012