OKUMURA Akihiko 奥村明彦

Researcher Number	70288512
Affiliation (based on the past Project Information) *help	2002 – 2008: 愛知医科大学, 医学部, 講師 1996: Aichi Medical Univ., School of Medicine, Assistant Professor, 医学部, 助手 1996: 愛知医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Biological Sciences / Gastroenterology
Keywords	Principal Investigator 自己免疫性肝炎 / Bad / TNF-R1 / toll-like receptor (TLR) / dendritic cells (DCs) / autoimmune hepatitis (AIH) / regulatory T cell (Tr) / 樹状細胞(DC) / IL-10 / サイトカイン … More / CTLA-4 / Foxp3 / 制御性T細胞 / CYP2D6 / real time PCR / apoptosis / Plasmacytoid DC / Myeloid DC / Toll-like receptor / アポトーシス抵抗性 / TNFα / TNFR1 / 樹状細胞 / 制御制T細胞 / リアルタイムPCR法 / アポトーシス / Toll-like receptor(TLR) / 自己免疫性肝炎(AIH) / 制御性T細胞(Tr) / cytokines / CD28 / TNF-R-SF18 / Toll-like receptors (TLR) / Toll-like receptors(TLR) / liver infiltrating lymphocytes / CD4^+ CD25^+-T cell (T-reg) / CD8^+-T cell / CD4^+-T cell / murine hepatitis model / 抗体産生 / 肝障害 / 特異的免疫応答 / CD8+T細胞 / CD4+T細胞 / 融合蛋白 / ベクター / 肝内浸潤リンパ球(LIL) / CD8比 / CD4 / CD4+CD25+T細胞 / ASGPR / マウスモデル … More Except Principal Investigator CTL / HBV / CD40 / IL-2 / α-galactosylceramide / transgenic mouse / B型肝炎ウイルス / NKT / TNF-α / トランスジェニックマウス / NKT cell / サイトカイン / NKT細胞 / 末梢血リンパ球 / 細胞障害性Tリンパ球 / 大腸癌 / レクチン / 肝転移 / CD4OL / cytotoxic T lymphocyte / hepatitis B virus / CD40L / knock-out mouse / DNAマイクロアレイ / 細胞傷害性Tリンパ球 / ノックアウトマウス / cytokine / intrahpepatic mononuclear cell / peripheral blood mononucler cell / α galactosylceramide / hepatocellular carcinoma / virus hepatitis / Vα24+T細胞 / T細胞受容体 / 肝臓癌 / C型肝炎 / Vα14 NKT knockouut mouse / マウスモデル / α GalCer / ウイルス性肝炎 / 樹状細胞 / αGalCer / 肝内リンパ球 / 肝臓がん / ウイルス肝炎 / antibody / Helper T cell / mutation / sequence / HLA-A2 / PBMC / 細胞障害性試験 / 肝内浸潤リンパ球 / B型急性肝炎 / 肝細胞障害 / e2エピトープ / アミノ酸変異 / GST融合蛋白 / HBVコア領域 / 急性増悪 / HLA拘束性 / B型慢性肝炎 / ASGPR / 胃癌 / ASGRP Less

ガラクトース型C型レクチンによる消化器癌転移の制御とその診断への応用
- Principal Investigator
  
  入村達郎
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Investigation of novel therapeutic approach through regulatory T cells (Tr) and dendritic cells (DCs) for the patients with autoimmune hepatitis (AIH)Principal Investigator
- Principal Investigator
  
  OKUMURA Akihiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
大腸癌肝転移形成におけるレクチンを介する接着と増殖の制御
- Principal Investigator
  
  入村達郎
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analysis and therapeutic application of crosstalk between innate immunity and acquired immunity in viral hepatitis.
- Principal Investigator
  
  ISHIKAWA Tetsuya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Roles of regulatory T cells (Tr) and dendritic cells (DCs) in the pathogenesis of autoimmune hepatitis(AIH)Principal Investigator
- Principal Investigator
  
  OKUMURA Akihiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Identification and clinical application for the role of NKT cells in patients with chronic hepatitis and hepatocellualr carcinoma infected hepatitis virus
- Principal Investigator
  
  KAKUMU Shinichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University School of Medicine
Analysis for the kinetics of host gene expression in the progression or recovery process of hepatic inflammation.
- Principal Investigator
  
  ISHIKAWA Tetsuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University School of Medicine
Establishment of murine model for auto immune hepatitis (AIH)Principal Investigator
- Principal Investigator
  
  OKUMURA Akihiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
Cellular immune response against HBV nucleocapsid antigen
- Principal Investigator
  
  KAKUMU Shinichi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Aichi Medical University
  Nagoya University

All 2008 2007 2006 2005 2003 Other

All Journal Article Presentation

[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppress or function of CD4+CD25+T cells in patients with autoimmune hepatitis2008
- Author(s)
  Okumura A, et. al.
- Journal Title
  
  Hepatology Research (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590754
[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppress or function of CD4+CD25+T cells in patients with autoimmune hepatitis2008
- Author(s)
  Okumura A, et al.
- Journal Title
  
  Hepatology Research 38
  
  Pages: 866-903
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590754
[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis2008
- Author(s)
  Okumura A, et al.
- Journal Title
  
  Hepatology Research 38
  
  Pages: 866-903
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590754
[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.2006
- Author(s)
  Ayada M, Ishikawa T, Okumura A, et al.
- Journal Title
  
  Hepatology Research 34
  
  Pages: 214-221
- NAID
  10020404871
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.2006
- Author(s)
  Ayada M, Ishikawa T, Okumura A, et al.
- Journal Title
  
  Hepatol Res 34
  
  Pages: 214-221
- NAID
  10020404871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Changes in natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma2005
- Author(s)
  Akihiko Okumura
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590644
[Journal Article] Changes in natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, et al.
- Journal Title
  
  Hepatol Res 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Changes on natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, et al.
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Data Source
  KAKENHI-PROJECT-17590688
[Journal Article] Changes in natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, et al.
- Journal Title
  
  Hepatol Res In press
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Changes in natural killer T cells subsets auring therapy in type C hepatitis and hepatocellular carcinoma2005
- Author(s)
  Okumura A, et al.
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Data Source
  KAKENHI-PROJECT-17014027
[Journal Article] Changes in natural killer T cell subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, et al.
- Journal Title
  
  Hepatol Res 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Changes on natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, et. al.
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590688
[Journal Article] Changes in natural killer T cell subsets during therapy in type C hepatitis and hepatocellular crcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, et al.
- Journal Title
  
  Hepatol Res 32
  
  Pages: 213-217
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Changes on natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma2005
- Author(s)
  Okumura A, et. al.
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590688
[Journal Article] Changes in natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, Sato K, Ayada M, Hotta N, Yamauchi T, Fukuzawa Y, Kakumu S.
- Journal Title
  
  Hepatology Research 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590644
[Journal Article] 自己免疫性肝炎(AIH)における制御性T細胞(Tr)の機能低下2005
- Author(s)
  奥村明彦
- Journal Title
  
  消化器と免疫 42
  
  Pages: 29-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590644
[Journal Article] Changes in natural killer T cells subsets during therapy in type C hepatitis and hepatocellular carcinoma.2005
- Author(s)
  Okumura A, Ishikawa T, Maeno T, et al.
- Journal Title
  
  Hopatology Research 32
  
  Pages: 213-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Mechanisms of increased insulin resistance in non-cirrhotic patients With chronic hepatitis C virus infection.2003
- Author(s)
  Maeno T, Okumura A, Ishikawa T, et al.
- Journal Title
  
  J Gastroenterol Hepatol 18
  
  Pages: 1358-1363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Mechanisms of increased insulin resistance in non-cirrhotic patients With chronic C virus infection.2003
- Author(s)
  Maeno T, Okumura A, Ishikawa T, et al.
- Journal Title
  
  J Gastroenterol Hepatol 18
  
  Pages: 1358-1363
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Mechanisms of increased insulin resistance in non-cirrhotic patients with chronic heaptitis C virus infection.2003
- Author(s)
  Maeno T, Okumura A, Ishikawa T, et al.
- Journal Title
  
  Journal of Gastroenterology and Hepatology 18
  
  Pages: 1358-1363
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Mechanisms of increased insulin resistance in non-cirrhotic patients with chronic hepatitis C virus infection.2003
- Author(s)
  Maeno T, Okumura A, Ishikawa T, et al.
- Journal Title
  
  J Gastroenterol Hepatol 18
  
  Pages: 1358-1363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590697
[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.
- Author(s)
  Ayada M, Ishikawa T, Okumura A, et al.
- Journal Title
  
  Hepatol Res In press
- NAID
  10020404871
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.
- Author(s)
  Ayada M, Ishikawa T, Okumura A, et al.
- Journal Title
  
  Hepatol Res (In press)
- NAID
  10020404871
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390236
[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.
- Author(s)
  Ayada M, Ishikawa T, Okumura A, et al.
- Journal Title
  
  Hepatol Res (In press)
- NAID
  10020404871
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390236
[Presentation] Dendritic cells in patients with autoimmune hepatitis are resistant to apoptosis induced through TNF receptor2008
- Author(s)
  Okumura A, et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2008-05-21
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590754
[Presentation] Dendritic cells in patients with autoimmune hepatitis are resistant to apoptosis induced through TNF receptor2008
- Author(s)
  Okumura A, et al.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego
- Year and Date
  2008-05-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590754
[Presentation] 自己免疫性肝炎(AIH)患者の樹状細胞(DC)におけるToll-like receptor(TLR)の発現プロフィールに関する検討〜健常人・C型慢性肝炎患者との比較〜2007
- Author(s)
  奥村明彦
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Data Source
  KAKENHI-PROJECT-18590754
[Presentation] 自己免疫性肝炎(AIH)患者の樹状細胞(DC)におけるアポトーシス関連分子の発現〜健常人・C型慢性肝炎患者との比較〜2007
- Author(s)
  奥村明彦, ら
- Organizer
  第43回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2007-05-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590754
[Presentation] Expression of apoptosis-related molecules on dendritic cells(DCs) in patients with autoimmune hepatitis(AIH).2007
- Author(s)
  Okumura A, et al.
- Organizer
  The 43th Annual Meeting of Japan Society of Hepatology
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590754

1. KAKUMU Shinichi (10115545)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
2. ISHIKAWA Tetsuya (10288508)

# of Collaborated Projects: 7 results

# of Collaborated Products: 15 results
3. 入村達郎 (80092146)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YOSHIDA Kentaro (60201852)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ITO Hiroyasu (80373075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中森正二 (70294080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. IWATA Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高柳正弘

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OKUMURA Akihiko 奥村 明彦

Research Projects

Research Products

Co-Researchers

ガラクトース型C型レクチンによる消化器癌転移の制御とその診断への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel therapeutic approach through regulatory T cells (Tr) and dendritic cells (DCs) for the patients with autoimmune hepatitis (AIH)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大腸癌肝転移形成におけるレクチンを介する接着と増殖の制御

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis and therapeutic application of crosstalk between innate immunity and acquired immunity in viral hepatitis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of regulatory T cells (Tr) and dendritic cells (DCs) in the pathogenesis of autoimmune hepatitis(AIH)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and clinical application for the role of NKT cells in patients with chronic hepatitis and hepatocellualr carcinoma infected hepatitis virus

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis for the kinetics of host gene expression in the progression or recovery process of hepatic inflammation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of murine model for auto immune hepatitis (AIH)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cellular immune response against HBV nucleocapsid antigen

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppress or function of CD4+CD25+T cells in patients with autoimmune hepatitis2008

Author(s)

Journal Title

Data Source

[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppress or function of CD4+CD25+T cells in patients with autoimmune hepatitis2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Deficiency of Foxp3 and CTLA-4 gene expression and impaired suppressor function of CD4+CD25+ T cells in patients with autoimmune hepatitis2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Alteration of serum cytokine balances among different phases of chronic hepatitis B virus infection.2006

Author(s)

OKUMURA Akihiko 奥村明彦