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NAGATA Masao  永田 正男

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永田 正男  ナガタ マサオ

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Researcher Number 70294220
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2008: 神戸大学, 大学院医学研究科, 准教授
2007 – 2008: Kobe University, Graduate School of Medicine, Professor
2007: 神戸大学, 医学系研究科, 准教授
2007: Kobe University, Graduate School of Medicine, Associate Professor
2006: 神戸大学, 大学院医学系研究科, 助教授 … More
2005 – 2006: 神戸大学, 大学院・医学系研究科, 助教授
2000: 神戸大学, 医学部, 助教授
1999: 神戸大学, 医学部・附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Metabolomics / 内科学一般
Except Principal Investigator
Metabolomics / Pathological medical chemistry
Keywords
Principal Investigator
NOD mouse / Dendritic cells / Pioglitazone / Thiazolidine derivative / Type 1 diabetes / 液体食事負荷試験 / チアゾリン誘導体 / NKT細胞 / 緩徐進行型1型糖尿病 / ピオグリタゾン … More / NODマウス / 樹状細胞 / ピオグルタゾン / チアゾリジン誘導体 / 1型糖尿病 / p53 / アデノウイルスベクター / 原発性肺癌 / アデノウイルス / 遺伝子治療 / 肺癌 / 食道癌 … More
Except Principal Investigator
mTOR / CD11c / 自己免疫 / 1型糖尿病 / 栄養センサー / immune tolerance / regulatory T cell / cytokine / regulatory dendritic cell / bone marrow cell / autoimmunity / type 1 diabetes / 免疫寛容 / 調節性T細胞 / サイトカイン / 制御性樹状細胞 / 骨髄細胞 / autoreactive T cell / insulin / Type 1 diabetes / 自己反応性T細胞 / インスリン / Nutrition Sensor / Energy Metabolism / Signal Transduction / 癌 / 糖尿病 / エネルギー代謝 / シグナル伝達 / 細胞内シグナル / 分子病態栄養学 Less
  • Research Projects

    (6 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (7 People)
  •  Regulation of mTOR-mediated nutrition sensing system

    • Principal Investigator
      HARA Kenta
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kobe University
  •  Prediction of human type 1 diabetes and preventive immune cell therapy using dendritic cells

    • Principal Investigator
      YASUDA Hisafumi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kobe University
  •  Physiological role and molecular mechanism of mTOR signaling as a sensor of nutrition

    • Principal Investigator
      HARA Kenta
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kobe University
  •  Research of prevention of type 1 diabetes by thiazolidine derivative.Principal Investigator

    • Principal Investigator
      NAGATA Masao
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kobe University
  •  Research of autoreactive Tcells to insulin as a major autoantigen in type 1 diabetes

    • Principal Investigator
      MORIYAMA Hiroaki
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Kobe University
  •  P53欠失/変異食道癌・肺癌に対するアデノベクターを用いた癌遺伝子治療Principal Investigator

    • Principal Investigator
      永田 正男
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Kobe University

All 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

  • [Book] Public Health Policy and Approaches for Noncommunicable Disease Prevention and Control in Japan : A case study2005

    • Author(s)
      Masao Nagata
    • Total Pages
      55
    • Publisher
      World Health Organization, Centre for Health development, Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Upregulation of the mTOR Complex 1 Pathway by Rheb in Pancreatic β Cells Leads to Increased β Cell Mass and Prevention of Hyperglycemia.2009

    • Author(s)
      Hamada S., Hara K., Hamada T., Yasuda H., Moriyama H., Nakayama R., Nagata M., Yokono K.
    • Journal Title

      Diabetes. 58

      Pages: 1321-1332

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Autoreactive T cell response in CD25 negative fraction of peripheral blood mononuclear cells from establishedtype 1 diabetes2008

    • Author(s)
      Morivama, H, Kotani, R, Katsuta, A, Kameno, M, Arai, T, Okumachi, Y, Kishi, M, Yamada, K, Yasuda, H, Hara, K, Yokono, K, Nagata M
    • Journal Title

      Ann N Y Acad Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulating molecules2008

    • Author(s)
      Sakata, M, Yasuda, H, Moriyama, H, Yamada, K, Kotani, R, Kurohara, M, Okumachi, Y, Kishi, M, Arai, T, Hara, K, Hamada, H, Yokono, K, Nagata, M
    • Journal Title

      Diabetes Res Clin Pract 80(3)

      Pages: 352-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Prevention of recurrent but not spontaneous autoimmune diabetes by transplanted NOD islets adenovirally transduced with immunomodulationg molecules.2008

    • Author(s)
      Sakata M., Yasuda H., Moriyama K., Yamada K., Kotani R., Kurohara M., Okumachi Y., Kishi M., Arai T., Hara K., Hamada H., Yokono K., Nagata M.
    • Journal Title

      Diabetes Res.Clin.Pract. 80

      Pages: 352-359

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] One amino acid difference is critical for suppression for the development of experimental autoimmune diabetes (EAD) with intravenous injection of insulin:9-23 peptide.2008

    • Author(s)
      Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi Okumachi Y., Moriyama H., Kameno M., Arai T., Kishi M., Kurohara M., Yamada K., Yasuda H., Hara K., Yokono K. Nagata M.
    • Journal Title

      Biochem. Biophys. Res. Commun. 374

      Pages: 581-586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Immunological aspects of 'fulminant type 1 diabetes'2008

    • Author(s)
      Nagata M, et. al.
    • Journal Title

      Diabetes Res Clin Pract.

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Modification of the Rb-binding Domain of Replication-Competent Adenovirus Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-kB Activity2007

    • Author(s)
      Yamada, K, Moriyama, H, Yasuda, H, Hara, K, Maniwa, Y, Hamada, H, Koichi, Yokono, Nagata, M
    • Journal Title

      Hum Gene Ther 18(5)

      Pages: 389-400

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice2007

    • Author(s)
      Moriyama, H., Nagata, M., T., Arai, Y., Okumachi, K., Yamada, R., Kotani, H., Yasuda, K., Hata, K, Yokono
    • Journal Title

      Diabetes Res Clin Pract S155-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knouckout NOD mice.2007

    • Author(s)
      Moriyama H., Nagata M., Arai T., Okumachi Y., Yamada K., Kotani R., Yasuda H., Hara K., Yokono K.
    • Journal Title

      Diabetes Res.Clin.Pract. 77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Immunological aspects of'fulminant type 1 diabetes2007

    • Author(s)
      Nagata, M, Morivama, H, Kotani, R, Yasuda, H, Kishi, M, Kurohara, M., Hara, K, Yokono, K
    • Journal Title

      Diabetes Res Clin Pract

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes'2007

    • Author(s)
      Nagata M
    • Journal Title

      Diabetes Research & Clinical Practice (in press)

    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes2007

    • Author(s)
      Masao, Nagata., et. al.
    • Journal Title

      Diabetes Res.Clin.Pract 77

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590990
  • [Journal Article] Immunological aspects of `fulminant type 1 diabetes'2007

    • Author(s)
      Nagata, M, H. Moriyama, R. Kotani, H. Yasuda, M. Kishi, M. Kurohara, K. Hara, K. Yokono
    • Journal Title

      Diabetes Res Clin Pract S99-S103

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes'2007

    • Author(s)
      Nagata M.
    • Journal Title

      Diabetes Res. Clin. Pract. 77

      Pages: 99-103

    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes'2007

    • Author(s)
      Nagata M
    • Journal Title

      Diabetes Research & Clinical Practice 77S

    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Immunological aspects of fulminant type 1 diabetes.2007

    • Author(s)
      Nagata M
    • Journal Title

      Diabetes Res Clin Pract. 77S

    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Regulation of hypoxia-inducible factor 1 by glucose availability under hypoxic conditions.2007

    • Author(s)
      Zhou J., Hara K., Inoue M., Hamada S., Yasuda H., Moriyama H., Endo H., Hirota K., Yonezawa K., Nagata M., Yokono K.
    • Journal Title

      Kobe J. Med. Sci 53

      Pages: 283-296

    • NAID

      110006646896

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes'2007

    • Author(s)
      Nagata M
    • Journal Title

      Diabetes Research & Clinical Practice (in press)

    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes2007

    • Author(s)
      Masao Nagata
    • Journal Title

      Diabetes Res.Clin.Pract. (in press)

    • Data Source
      KAKENHI-PROJECT-18590990
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes2007

    • Author(s)
      Masao Nagata
    • Journal Title

      Diabetes Res. Clin. Pract. 77

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590990
  • [Journal Article] Modification of the Rb-binding Domain of Replication- Competent Adenovirus Vector Enhances Cytotoxicity Against Human Esophageal Cancers via NF-kB Activity.2007

    • Author(s)
      Yamada K., Moriyama H., Yasuda H., Hara K., Maniwa Y., Hamada H., Yokono K., Nagata M.
    • Journal Title

      Human Gene Therapy 2007 18

      Pages: 389-400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice2007

    • Author(s)
      Morivama, H, Nagata, M., Arai, T, Okumachi, Y, Yamada, K, Kotani, R, Yasuda, H, Hara, K, Yokono, K
    • Journal Title

      Diabetes Res Clin Pract 23:77S

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Immunological aspects of fluminant type 1 diabetes2007

    • Author(s)
      Nagata M
    • Journal Title

      Diabetes Res Clin Pract. S99

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Prevention of the manifestation of diabetes in the elderly in the presymptomatic stage2006

    • Author(s)
      永田 正男
    • Journal Title

      Nippon Ronen Igakkai Zasshi. 43

      Pages: 84-86

    • NAID

      10020554609

    • Data Source
      KAKENHI-PROJECT-17590931
  • [Journal Article] A possible association of ProI2Ala polymorphism in peroxisome proliferator-activated receptor gamma2 gene with obesity in native Javanese in Indonesia2005

    • Author(s)
      Danawati, C. W., Nagata, M., Moriyama, H., Hara, K., Yasuda, H., Nakayama, M., Kotani, R., Yamada, K., Sakata, M., Kurohara, M., Wiyono, P., Asdie, H., Sakaue, M., Taniguchi, H., Yokono. K
    • Journal Title

      Diabetes Metab Res 21

      Pages: 465-469

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes.

    • Author(s)
      Nagata M.
    • Journal Title

      Diabetes Res.Clin.Pract. (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590267
  • [Journal Article] Immunological Aspects of 'Fulminant Type 1 Diabetes.

    • Author(s)
      Nagata M., Moriyama H., Kotani R., Yasuda H., Kishi M., Kurohara M., Hara K., Yokono K.
    • Journal Title

      Diabetes Res. Clin. Pract.

      Pages: 0-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes.

    • Author(s)
      Nagata M.
    • Journal Title

      Diabetes Res.Clin.Pract. (In press)

    • Data Source
      KAKENHI-PROJECT-17590267
  • [Journal Article] Immunological Aspects of Fulminant Type 1 Diabetes.

    • Author(s)
      Nagata M.
    • Journal Title

      Diabetes Research & Clinical Practice (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590267
  • [Journal Article] Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes

    • Author(s)
      Kurohara, M, Yasuda, H, Moriyama, H, Sakata, M, Yamada, K, Kotani, R, Nakayama, M, Hara, K, Yokono, K, Nagata, M
    • Journal Title

      Kobe J. Med. Sci (in press)

    • NAID

      110006648210

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590931
  • [Presentation] Upregulation of mTORC1 pathway by Rheb in pancreatic βcells leads to increased β cell mass and prevention of hyperglycemia. 68th Scientific Sessions2008

    • Author(s)
      Kenta Hara, Suirin Hamada, Akira Nakamura, Hisafumi Yasuda, Hiroaki Moriyama, Masao Nagata, Koichi Yokono
    • Organizer
      The American Diabetes Association
    • Place of Presentation
      San Francisco, CA, USA
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Presentation] 膵β細胞におけるmTORシグナルの活性化と糖尿病発症の抑制2008

    • Author(s)
      濱田水鈴、原 賢太、中村 晃、安田尚史、森山啓明、永田正男、横野浩一
    • Organizer
      第50回日本老年医学会学術集会・総会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Presentation] mTORシグナルのRhebによる活性化は膵β細胞の成長を促し高血糖を抑制する2008

    • Author(s)
      濱田水鈴、原 賢太、中村 晃、安田尚史、森山啓明、永田正男、横野浩一
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Presentation] RhebによるmTORC1経路の活性化は膵β細胞の成長を促し高血糖を抑制する2007

    • Author(s)
      原 賢太、濱田水鈴、濱田 猛、中村 晃、安田尚史、森山啓明、永田正男、横野浩一
    • Organizer
      第19回分子糖尿病学シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2007-12-08
    • Data Source
      KAKENHI-PROJECT-19590308
  • [Presentation] Autoreactive T cell responses in CD25 negative fraction of peripheral blood mononuclear cells from established type 1 diabetes2007

    • Author(s)
      Morivama, H., Kotani, R., Kameno, M., Arai, T, Okumachi, Y., Kishi, M., Kurohara, M, Yasuda, H., Yamada, K., Yokono, K, Nagata M
    • Organizer
      the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
    • Place of Presentation
      Miami, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Presentation] One amino acid difference of insulin:9-23 peptides critically influence on the effect of deletional therapy for experimental autoimmune diabetes (EAD). Acta Diabetologia Vol. 44, S36 Poster presentation at the 9°i International Congress of the immunology of Diabetes Society and American Diabetes Association Research Symposium at Miami, November 20072007

    • Author(s)
      Okumachi, Y., Moriyama, H., Kameno, M., Arai, T, Kishi, M., Kurohara, M, Yamada, K., Yasuda, H., Yokono, K., Nagata, M
    • Organizer
      the 9th International Congress of the immunology of Diabetes Society and American Diabetes Association Research (IDS-9)
    • Place of Presentation
      Miami, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Presentation] Intravenous Administration of Insulinl B9-23 Peptide Reduces T Cell Reactivity to Insulin and Protects Autoimmune Diabetes in Experimental Autoimmune Diabetes2006

    • Author(s)
      Okumachi, Y, Morivama, H., Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Kotani, R., Yasuda, H., Hara, K., Yokono, K., Nagata, M
    • Organizer
      the 66th American Diabetes Association (ADA) meeting
    • Place of Presentation
      Washington DC, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Presentation] Subcutaneous transplantation with Proinsulin2 expressing fibroblasts protects diabetes in NOD mice2006

    • Author(s)
      Yamada, K., Moriyama, H., Okumachi, Y, Arai, T., Kishi, M., Kurohara, M., Yasuda, H., Hara, K, Yokono, K., Nagata, M
    • Organizer
      the 66th American Diabetes Association (ADA) meeting
    • Place of Presentation
      Washington DC, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • [Presentation] Insulin reactive T cells in EAD(Exprimental Autoimmune Diabetes) Model2005

    • Author(s)
      Moriyama, H, Nagata, M, Kotani, R, Okumachi, Y, Arai, T, Yamada, K, Yasuda, H, Eisenbarth, GS, Yokono, K
    • Organizer
      the 8th Meeting of the Immunology of Diabetes Society (IDS-8)
    • Place of Presentation
      Awaji Island
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590932
  • 1.  YOKONO Koichi (50144580)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 25 results
  • 2.  MORIYAMA Hiroaki (70372646)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 20 results
  • 3.  HARA Kenta (70397826)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 19 results
  • 4.  YASUDA Hisafumi (50403233)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 11 results
  • 5.  NAKAMURA Masato (40227921)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TAKAHASHI Kazuma (60292215)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAWAMURA Tomoyuki (60271186)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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