Hirahashi Jun'ichi 平橋淳一

… Alternative Names

HIRAHASHI Junichi 平橋淳一

平橋淳一ヒラハシジュンイチ

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Researcher Number	70296573
Other IDs	https://orcid.org/0000-0003-3881-2322
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 慶應義塾大学, 医学部(信濃町), 講師 2014 – 2015: 慶應義塾大学, 医学部, 講師 2010 – 2013: 東京大学, 医学部附属病院, 助教 2005 – 2006: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 54010:Hematology and medical oncology-related / Hematology / 膠原病・アレルギー・感染症内科学 / Kidney internal medicine Except Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine
Keywords	Principal Investigator 血栓 / 好中球 / 炎症 / ラクトフェリン / 血小板 / Mac-1 / 急性炎症 / Immunothrombosis / 糖尿病 / ヒストン … More / 腎炎 / 構造活性相関研究 / ペプチド / 構造修飾 / 腹腔内免疫 / 腸内環境 / 中分子ペプチド / 横紋筋融解症後急性腎障害 / 白血球細胞外トラップ / リン酸化 / 金属同位体標識 / CyTOF / CD11ｂ / DAMPs / 血管障害 / 細胞外ヒストン / PSGL-1 / CD40L / NETｓ / 血管炎 / 自己免疫 / 好中球細胞外トラップ / vasculitis / autoimmune / lactoferrin / inflammation / neutrophil / 免疫複合体 / Mac1 / エラスターゼ / 血尿 / 急性腎不全 / 糸球体腎炎 … More Except Principal Investigator スフィンゴリン脂質 / 自己免疫性疾患 / 腎障害 / 活性酸素種 / NADPHオキシダーゼ / PKCδ / SHP-1 / Lyn / STIM1 / 好中球 / Fcγ受容体IIA / Fc受容体 / HDAC / DNAメチル化 / エピジェネティクス / DNA メチル化 / ヒストン脱アセチル化酵素 / 糖尿病性腎症 / 慢性腎臓病 Less

Development of Novel Therapeutic Agents for Crush Syndrome by Targeting Leukocyte Extracellular TrapsPrincipal Investigator
- Principal Investigator
  
  平橋淳一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Keio University
Regulation in affinity of Fc receptor by sphingolipids
- Principal Investigator
  
  OKUBO Koshu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
Elucidation of inflammatory mechanism and development of new treatment by immunological analysis of platelet-leukocyte contactPrincipal Investigator
- Principal Investigator
  
  HIRAHASHI Junichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Keio University
Investigation of Dysregulated Immunothrombosis in inflammatory diseases and development of a new therapeutic tool.Principal Investigator
- Principal Investigator
  
  Hirahashi Junichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Regulation of neutrophil extracellular traps via fenton reaction and its application to the treatment of refractory autoimmune vasculitisPrincipal Investigator
- Principal Investigator
  
  HIRAHASHI Junichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Keio University
  The University of Tokyo
Studies of epigenetic abnormalities in chronic kidney disease as a novel therapeutic target
- Principal Investigator
  
  MARUMO Takeshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
  Kyorin University
腎糸球体内微小血栓の形成過程における白血球接着因子の機能解析と治療への応用Principal Investigator
- Principal Investigator
  
  平橋淳一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2006 2005 Other

All Journal Article Presentation Book Patent Other

[Book] 医学のあゆみ2016
- Author(s)
  山崎修、平橋淳一
- Total Pages
  7
- Publisher
  日本医学社
- Data Source
  KAKENHI-PROJECT-15K09459
[Book] 新膠原病・血管炎の腎障害2016
- Author(s)
  大久保光修、平橋淳一
- Publisher
  東京医学社
- Data Source
  KAKENHI-PROJECT-15K09459
[Journal Article] 疾患REVIEW　横紋筋融解症と急性腎障害(解説)2020
- Author(s)
  平橋　淳一
- Journal Title
  
  SRL宝函
  
  Volume: 41巻1号 Pages: 11-21
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies2020
- Author(s)
  Sada KE, Ohashi K, Asano Y, Hayashi K, Morishita M, Watanabe H, Matsumoto Y, Fujimoto S, Takasaki Y, Yamagata K, Banno S, Dobashi H, Amano K, Harigai M, Arimura Y, Makino H and Hirahashi J as a collaborator.
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 22 Issue: 1
- DOI
  10.1186/s13075-020-02341-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08339, KAKENHI-PROJECT-17K09986
[Journal Article] 【腎臓と運動・スポーツ】運動後急性腎不全　横紋筋融解症による腎不全(解説/特集)2020
- Author(s)
  大久保光修、平橋　淳一
- Journal Title
  
  腎と透析
  
  Volume: 88巻4号 Pages: 526-532
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps2020
- Author(s)
  Tanaka Mototsugu, Kinoshita-Daitoku Ryo, Kiga Kotaro, Sanada Takahito, Zhu Bo, Okano Tokuju, Aikawa Chihiro, Iida Tamako, Ogura Yoshitoshi, Hayashi Tetsuya, Okubo Koshu, Kurosawa Miho, Hirahashi Junichi, Suzuki Toshihiko, Nakagawa Ichiro, Nangaku Masaomi, Mimuro Hitomi
- Journal Title
  
  Scientific Reports
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] Association between age at disease onset of anti-neutrophil cytoplasmic antibody?associated vasculitis and clinical presentation and short-term outcomes2020
- Author(s)
  Monti S, Craven A, Klersy C, Montecucco C, Caporali R, Watts R, Merkel PA, Luqmani R and Hirahashi J as a collaborator.
- Journal Title
  
  Rheumatology
  
  Volume: 60 Issue: 2 Pages: 617-628
- DOI
  10.1093/rheumatology/keaa215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] 【腎疾患コンサルテーション】急性腎障害(AKI)　横紋筋融解症/クラッシュシンドロームへの対応　(解説/特集)2020
- Author(s)
  平橋　淳一
- Journal Title
  
  腎と透析
  
  Volume: 89巻4号 Pages: 546-549
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] 急性腎障害におけるMETsの関与とその制御2019
- Author(s)
  平橋　淳一
- Journal Title
  
  炎症と免疫
  
  Volume: 27 Pages: 284-288
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] 横紋筋融解症・腎臓専門医の視点より2019
- Author(s)
  大久保光修、平橋　淳一
- Journal Title
  
  腎と透析
  
  Volume: 86 Pages: 491-493
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] 圧挫症候群における腎障害のメカニズム2019
- Author(s)
  大久保光修、平橋　淳一
- Journal Title
  
  腎臓内科・泌尿器科
  
  Volume: 10 Pages: 260-265
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] 横紋筋融解症による急性腎障害発症の新たなメカニズム2019
- Author(s)
  平橋　淳一
- Journal Title
  
  医学のあゆみ
  
  Volume: 268 Pages: 587-588
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] NETsに対する治療戦略2019
- Author(s)
  平橋　淳一
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 4 Pages: 325-332
- Data Source
  KAKENHI-PROJECT-18K08339
[Journal Article] Macrophage extracellular chromatin release induced by Mac-1 mediated platelet-macrophage interactions triggers acute kidney injury in rhabdomyolysis.2018
- Author(s)
  Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J.
- Journal Title
  
  Nat. Med.
  
  Volume: 24 Issue: 2 Pages: 232-238
- DOI
  10.1038/nm.4462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-16H02606, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-15K09459, KAKENHI-PROJECT-16K15294, KAKENHI-PROJECT-16K19497, KAKENHI-PUBLICLY-16H01369
[Journal Article] Mac-1 Signaling Via Src-family and Syk Kinases results in elastase dependent thrombohemorrhagic vasculopathy.2006
- Author(s)
  Hirahashi J, Mekala D, Ziffle JV, Xiao L, Saffaripour S, etc
- Journal Title
  
  Immunity 25
  
  Pages: 271-283
- Data Source
  KAKENHI-PROJECT-17790547
[Journal Article] Inducible Co-Stimulator Null MRL-Faslpr Mice : Uncoupling of Autoantibodlies and T Cell Responses in Lupus. 122-30, 20062006
- Author(s)
  Zeller GC, Hirahashi J Schwarting A, Sharpe AH, Kelley VR
- Journal Title
  
  J Am Soc Nephrol 17
  
  Pages: 122-130
- Data Source
  KAKENHI-PROJECT-17790547
[Journal Article] Regulation of vascular endothelial barrier function by Epac, a cAMP activated exchange factor for Rap GTPase.2005
- Author(s)
  Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN
- Journal Title
  
  Blood 105
  
  Pages: 1950-1955
- Data Source
  KAKENHI-PROJECT-17790547
[Journal Article] Inducible co-stimulator null MRL-Faslpr mice : uncaupling of autoantibodies and T cell responses in lupus.
- Author(s)
  Zeller GC, Hirahashi J, Schwarting A, Sharpe AH etc
- Data Source
  KAKENHI-PROJECT-17790547
[Patent] ①白血球の細胞外トラップ形成の阻害剤2014
- Inventor(s)
  平橋淳一
- Industrial Property Rights Holder
  平橋淳一
- Industrial Property Rights Type
  特許
- Filing Date
  2014-10-08
- Data Source
  KAKENHI-PROJECT-24591461
[Patent] ①白血球の細胞外トラップ形成の阻害剤2014
- Inventor(s)
  平橋淳一
- Industrial Property Rights Holder
  平橋淳一
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-08
- Overseas
- Data Source
  KAKENHI-PROJECT-24591461
[Patent] 白血球の細胞外トラップ形成の阻害剤2013
- Inventor(s)
  平橋淳一、浦野泰照、大久保光修、神谷真子、加賀谷伸治
- Industrial Property Rights Holder
  国立大学法人東京大学、株式会社ＮＲＬファーマ
- Industrial Property Rights Type
  特許
- Filing Date
  2013
- Overseas
- Data Source
  KAKENHI-PROJECT-24591461
[Patent] 白血球の細胞外トラップ形成の阻害剤2013
- Inventor(s)
  平橋淳一
- Industrial Property Rights Holder
  平橋淳一
- Industrial Property Rights Type
  特許
- Filing Date
  2013
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] 災害大国日本における横紋筋融解症 AKI とラクトフェリン2021
- Author(s)
  平橋　淳一
- Organizer
  日本ラクトフェリン学会第9回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08339
[Presentation] 糖尿病では急性期傷害関連タンパクHistoneに対する白血球の炎症免疫応答が亢進している2019
- Author(s)
  平橋　淳一、黒澤　美穂、大久保　光修
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08339
[Presentation] 糖尿病では急性期傷害関連タンパクHistoneに対する白血球の炎症免疫応答が亢進している2019
- Author(s)
  平橋　淳一
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08339
[Presentation] 糖尿病における心血管病への脆弱性を白血球の急性期タンパクヒストンへの反応性から解析する2019
- Author(s)
  平橋　淳一
- Organizer
  第10回日本プライマリ・ケア連合学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08339
[Presentation] 炎症急性期タンパクHistoneに対する感受性とThromboinflammation2019
- Author(s)
  平橋　淳一
- Organizer
  第25回MPO研究会
- Data Source
  KAKENHI-PROJECT-18K08339
[Presentation] Histone requires Mac-1 (CD11b/CD18)-mediated neutrophil-platelet interaction to induce thromboembolism2017
- Author(s)
  Miho Kurosawa ，Koshu Okubo ，Osamu Yamazaki ，Matsuhiko Hayashi , Junichi Hirahashi
- Organizer
  第18回国際血管炎・ANCA学会
- Place of Presentation
  伊藤国際学術研究センター（東京都文京区）
- Year and Date
  2017-03-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09459
[Presentation] 糖尿病における易血栓性はhistone感受性の亢進を背景としたimmunothrombosis制御異常に起因する2016
- Author(s)
  黒澤美穂、大久保光修、山崎修、下澤達雄、南学正臣、林松彦、平橋淳一
- Organizer
  第59回日本腎臓学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県西区）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K09459
[Presentation] Lactoferrin modulates “Immunothrombosis” in inflammatory diseases2015
- Author(s)
  Junichi Hirahashi
- Organizer
  第12回国際ラクトフェリン学会
- Place of Presentation
  ウエスティンナゴヤキャッスル（愛知県名古屋市西区）
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09459
[Presentation] ANCA血管炎・腎炎の免疫学と治療2015
- Author(s)
  平橋淳一
- Organizer
  第45回日本腎臓学会東部学術大会
- Place of Presentation
  東京ミッドタウン（東京都港区）
- Year and Date
  2015-10-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K09459
[Presentation] ラクトフェリン：炎症性および血栓性疾患に対する新たな治療薬としての可能性2014
- Author(s)
  平橋淳一
- Organizer
  日本ラクトフェリン学会第6回学術集会
- Place of Presentation
  エポカルつくば（茨城県つくば市）
- Year and Date
  2014-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] ANCA血管炎の病態メカニズムと新たな治療法への展望2014
- Author(s)
  平橋淳一
- Organizer
  腎臓血管加齢機構血管炎をもっと知ろう（第2回）
- Place of Presentation
  東京都健康長寿医療センター（東京都板橋区）
- Year and Date
  2014-11-23
- Invited
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] 好中球細胞外トラップ（NETs）抑制物質ラクトフェリンの機能解析2014
- Author(s)
  大久保光修、林松彦、神谷真子、浦野泰照、西裕志、Tanya Mayadas、藤田敏郎、南学正臣、平橋淳一
- Organizer
  第５回分子腎臓フォーラム
- Place of Presentation
  ベルサール八重洲（東京都中央区）
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] 好中球細胞外トラップ（NETs）を制御する物質：ラクトフェリン2014
- Author(s)
  平橋　淳一、大久保　光修、神谷　真子、浦野　泰照、加賀谷　伸治
- Organizer
  第19回日本血管病理研究会
- Place of Presentation
  両国ＫＦＣビル（東京都墨田区）
- Year and Date
  2014-10-04
- Invited
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] ＡＮＣＡ関連血管炎の病態と新たな治療法2014
- Author(s)
  平橋淳一
- Organizer
  第７回基礎と臨床を結ぶ分子病態研究会
- Place of Presentation
  学士会館（東京都千代田区）
- Year and Date
  2014-11-01
- Invited
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] Lactoferrin Is a Suppressor of Neutrophil Extracellular Traps in Inflammation2013
- Author(s)
  Koshu Okubo, Masaomi Nangaku, Toshiro Fujita, Junichi　Hirahashi
- Organizer
  2013 American Society of Nephrology (Atlanta)
- Place of Presentation
  アトランタ（アメリカ）
- Data Source
  KAKENHI-PROJECT-24591461
[Presentation] Lactoferrin is a suppressor of neutrophil extracellular traps in inflammation2013
- Author(s)
  Koshu Okubo, Mako Kamiya, Yasuteru Urano, Hiroshi Nishi, Jan Herter, Tanya Mayadas, Daigoro Hirohama, Kazuo Suzuki, Tomokazu Nagao, Mototsugu Tanaka, Miho Kurosawa, Shinji Kagaya, Keiichi Hishikawa, Masaomi Nangaku, Toshiro Fujita, and Junichi Hirahashi
- Organizer
  XIth International Conference on Lactoferrin:Structure, Function, and Applications (2013 Rome)
- Place of Presentation
  ローマ（イタリア）
- Data Source
  KAKENHI-PROJECT-24591461
[]
[]

1. OKUBO Koshu (60749125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. MARUMO Takeshi (70265817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. URANO Yasuteru (20292956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KAMIYA Mako (90596462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. KAWAKAMI Hiroshi (90458860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 高山健太郎 (70611482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 長谷耕二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirahashi Jun'ichi 平橋 淳一

HIRAHASHI Junichi 平橋 淳一

平橋 淳一 ヒラハシ ジュンイチ

Research Projects

Research Products

Co-Researchers

Development of Novel Therapeutic Agents for Crush Syndrome by Targeting Leukocyte Extracellular TrapsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation in affinity of Fc receptor by sphingolipids

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of inflammatory mechanism and development of new treatment by immunological analysis of platelet-leukocyte contactPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Dysregulated Immunothrombosis in inflammatory diseases and development of a new therapeutic tool.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of neutrophil extracellular traps via fenton reaction and its application to the treatment of refractory autoimmune vasculitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of epigenetic abnormalities in chronic kidney disease as a novel therapeutic target

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腎糸球体内微小血栓の形成過程における白血球接着因子の機能解析と治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 新膠原病・血管炎の腎障害2016

Author(s)

Publisher

Data Source

[Journal Article] 疾患REVIEW 横紋筋融解症と急性腎障害(解説)2020

Author(s)

Journal Title

Data Source

[Journal Article] Treatment-related damage in elderly-onset ANCA-associated vasculitis: safety outcome analysis of two nationwide prospective cohort studies2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【腎臓と運動・スポーツ】運動後急性腎不全 横紋筋融解症による腎不全(解説/特集)2020

Author(s)

Journal Title

Data Source

[Journal Article] Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps2020

Author(s)

Journal Title

Data Source

[Journal Article] Association between age at disease onset of anti-neutrophil cytoplasmic antibody?associated vasculitis and clinical presentation and short-term outcomes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【腎疾患コンサルテーション】急性腎障害(AKI) 横紋筋融解症/クラッシュシンドロームへの対応 (解説/特集)2020

Hirahashi Jun'ichi 平橋淳一

HIRAHASHI Junichi 平橋淳一

平橋淳一ヒラハシジュンイチ

[Journal Article] 疾患REVIEW　横紋筋融解症と急性腎障害(解説)2020

[Journal Article] 【腎臓と運動・スポーツ】運動後急性腎不全　横紋筋融解症による腎不全(解説/特集)2020

[Journal Article] 【腎疾患コンサルテーション】急性腎障害(AKI)　横紋筋融解症/クラッシュシンドロームへの対応　(解説/特集)2020