OYAKE Mutsuo 小宅睦郎

Researcher Number	70313559
Affiliation (based on the past Project Information) *help	2003 – 2004: 新潟大学, 医歯学総合病院, 助手 2003: 新潟大学, 医学附属病院, 助手 2001 – 2003: 新潟大学, 医学部附属病院, 助手 2001: 新潟大学, 医学部・付属病院, 助手 2000 – 2001: 新潟大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology / Neurology / Biological Sciences
Keywords	Principal Investigator 脊髄小脳変性症 / モデル動物 / ポリグルタミン病 / 歯状核赤核淡蒼球ルイ体萎縮症 / TAFII130 / CREB転写 / モデルマウス / CREB依存性転写 / ボリグルタミン病 / DRPLA / てんかん / レポーター遺伝子 / ノックアウトマウス … More Except Principal Investigator … More DNA repair / XRCC1 / polyglutamine / 脊髄小脳変性症 / poly(ADP-ribose)polymerase / APTX / UPS / spinocerebellar degeneration / ocular motor apraxia / aprataxin / DNA修復 / microtubules filaments / intermediate filaments / aggresome / MTOC / unfolding protein / DRPLA / Huntington disease / CAG repeat / CREB mediated transcription / spinocerebellar ataxia / CREB依存性転写 / ポリグルタミン / cerebellum / liypoalbuminemia / single strand DNA break / hypoalbuminemia / hypoalbuminenia / DNA Repair / spinoxerebellar degeneration / 小脳 / 低アルブミン血症 / 眼球運動失行 / アプラタキシン / 一本鎖DNA修復 / huntington disease / polygultamine / dentatorubral-pallidoluysian atrophy / expression profiling / CREB-dependent transcriptional activation / cAMP-responsive gene / transcriptional dysregulation / nuclear accumulation / polyglutamine diseases / TAFII130 / 神経細胞死 / 転写因子 / 遺伝性神経変性疾患 / トランスジェニックマウス / c-fos / CREB-依存性転写活性化 / animal model / transcription / polyglutamine disease / molecular mechanism / neurodegeneration / 歯状核赤核・淡倉球ルイ体萎縮症 / CAGリピート / 歯状核赤核・淡蒼球ルイ体萎縮症 / 遺伝子発現プロファイリング / CREB依存性転写活性化 / cAMP依存性遺伝病 / 転写障害 / 核内集積 / ポリグルタミン病 Less

Transcriptional disturbance and Neurodegeneration.
- Principal Investigator
  
  ONODERA Osamu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  NIIGATA UNIVERSITY
モデル動物を用いた伸長ポリグルタミン鎖がCREB依存性転写活性化に及ぼす効果Principal Investigator
- Principal Investigator
  
  小宅睦郎
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Identified the causative gene for EAOH end elucidation the molecular mechanisms of neurodegeneration in EAOH
- Principal Investigator
  
  TSUJI Shoji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Research for the role of dystrophic neurites in neuronal cell dysfunction of Polyglutamine disease
- Principal Investigator
  
  ONODERA Osamu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
ノックアストマウスによるDRPLA遺伝子の機能と発現分布に関する研究Principal Investigator
- Principal Investigator
  
  小宅睦郎
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Molecular mechanisms of neurodegeneration
- Principal Investigator
  
  TSUJI Shoji
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Niigata University

All 2004

All Journal Article

[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004
- Author(s)
  Sano, Y., Date, H, Igarashi, S, Onodera, O, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S
- Journal Title
  
  Ann. Neurol. 55
  
  Pages: 241-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210008
[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004
- Author(s)
  Sano, Y., Date, H, Igarashi, S, Onodera, 0, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S.
- Journal Title
  
  Ann. Neurol 55
  
  Pages: 241-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210008
[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein wi2004
- Author(s)
  Sano, Y., Date, H, Igarashi, S, Onodera, O, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S.
- Journal Title
  
  Ann.Neurol. 55
  
  Pages: 241-249
- Data Source
  KAKENHI-PROJECT-12210008
[Journal Article] Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.2004
- Author(s)
  Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S.
- Journal Title
  
  Ann Neurol. 55(2)
  
  Pages: 241-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390272

1. ONODERA Osamu (20303167)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. TSUJI Shoji (70150612)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. GOTO Jun (10211252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKAHASHI Yuji (00372392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. IGARASHI Shuichi (60345519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 清水潤 (40260492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 成瀬聡 (70313541)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OYAKE Mutsuo 小宅 睦郎

Research Projects

Research Products

Co-Researchers

Transcriptional disturbance and Neurodegeneration.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モデル動物を用いた伸長ポリグルタミン鎖がCREB依存性転写活性化に及ぼす効果Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identified the causative gene for EAOH end elucidation the molecular mechanisms of neurodegeneration in EAOH

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for the role of dystrophic neurites in neuronal cell dysfunction of Polyglutamine disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ノックアストマウスによるDRPLA遺伝子の機能と発現分布に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of neurodegeneration

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein wi2004

Author(s)

Journal Title

Data Source

[Journal Article] Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.2004

Author(s)

Journal Title

Description

Data Source

OYAKE Mutsuo 小宅睦郎