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OYAKE Mutsuo  小宅 睦郎

ORCIDConnect your ORCID iD *help
Researcher Number 70313559
Affiliation (based on the past Project Information) *help 2003 – 2004: 新潟大学, 医歯学総合病院, 助手
2003: 新潟大学, 医学附属病院, 助手
2001 – 2003: 新潟大学, 医学部附属病院, 助手
2001: 新潟大学, 医学部・付属病院, 助手
2000 – 2001: 新潟大学, 医学部・附属病院, 助手
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology / Neurology / Biological Sciences
Keywords
Principal Investigator
脊髄小脳変性症 / モデル動物 / ポリグルタミン病 / 歯状核赤核淡蒼球ルイ体萎縮症 / TAFII130 / CREB転写 / モデルマウス / CREB依存性転写 / ボリグルタミン病 / DRPLA / てんかん / レポーター遺伝子 / ノックアウトマウス … More
Except Principal Investigator
… More DNA repair / XRCC1 / polyglutamine / 脊髄小脳変性症 / poly(ADP-ribose)polymerase / APTX / UPS / spinocerebellar degeneration / ocular motor apraxia / aprataxin / DNA修復 / microtubules filaments / intermediate filaments / aggresome / MTOC / unfolding protein / DRPLA / Huntington disease / CAG repeat / CREB mediated transcription / spinocerebellar ataxia / CREB依存性転写 / ポリグルタミン / cerebellum / liypoalbuminemia / single strand DNA break / hypoalbuminemia / hypoalbuminenia / DNA Repair / spinoxerebellar degeneration / 小脳 / 低アルブミン血症 / 眼球運動失行 / アプラタキシン / 一本鎖DNA修復 / huntington disease / polygultamine / dentatorubral-pallidoluysian atrophy / expression profiling / CREB-dependent transcriptional activation / cAMP-responsive gene / transcriptional dysregulation / nuclear accumulation / polyglutamine diseases / TAFII130 / 神経細胞死 / 転写因子 / 遺伝性神経変性疾患 / トランスジェニックマウス / c-fos / CREB-依存性転写活性化 / animal model / transcription / polyglutamine disease / molecular mechanism / neurodegeneration / 歯状核赤核・淡倉球ルイ体萎縮症 / CAGリピート / 歯状核赤核・淡蒼球ルイ体萎縮症 / 遺伝子発現プロファイリング / CREB依存性転写活性化 / cAMP依存性遺伝病 / 転写障害 / 核内集積 / ポリグルタミン病 Less
  • Research Projects

    (6 results)
  • Research Products

    (4 results)
  • Co-Researchers

    (7 People)
  •  Transcriptional disturbance and Neurodegeneration.

    • Principal Investigator
      ONODERA Osamu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      NIIGATA UNIVERSITY
  •  モデル動物を用いた伸長ポリグルタミン鎖がCREB依存性転写活性化に及ぼす効果Principal Investigator

    • Principal Investigator
      小宅 睦郎
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Identified the causative gene for EAOH end elucidation the molecular mechanisms of neurodegeneration in EAOH

    • Principal Investigator
      TSUJI Shoji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokyo
  •  Research for the role of dystrophic neurites in neuronal cell dysfunction of Polyglutamine disease

    • Principal Investigator
      ONODERA Osamu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  ノックアストマウスによるDRPLA遺伝子の機能と発現分布に関する研究Principal Investigator

    • Principal Investigator
      小宅 睦郎
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Molecular mechanisms of neurodegeneration

    • Principal Investigator
      TSUJI Shoji
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      Niigata University

All 2004

All Journal Article

  • [Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004

    • Author(s)
      Sano, Y., Date, H, Igarashi, S, Onodera, O, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S
    • Journal Title

      Ann. Neurol. 55

      Pages: 241-249

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12210008
  • [Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004

    • Author(s)
      Sano, Y., Date, H, Igarashi, S, Onodera, 0, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S.
    • Journal Title

      Ann. Neurol 55

      Pages: 241-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12210008
  • [Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein wi2004

    • Author(s)
      Sano, Y., Date, H, Igarashi, S, Onodera, O, Oyake, M, Takahashi, T, Hayashi, S, Morimatsu, M, Takahashi, H, Makifuchi, T, Fukuhara, N, Tsuji, S.
    • Journal Title

      Ann.Neurol. 55

      Pages: 241-249

    • Data Source
      KAKENHI-PROJECT-12210008
  • [Journal Article] Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair protein.2004

    • Author(s)
      Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S.
    • Journal Title

      Ann Neurol. 55(2)

      Pages: 241-249

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390272
  • 1.  ONODERA Osamu (20303167)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  TSUJI Shoji (70150612)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  GOTO Jun (10211252)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKAHASHI Yuji (00372392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  IGARASHI Shuichi (60345519)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  清水 潤 (40260492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  成瀬 聡 (70313541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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