INOUE Hirofumi 井上博文

… Alternative Names

Researcher Number	70321635
Affiliation (based on the past Project Information) *help	2014: 愛媛大学, 大学院医学系研究科, 講師 2012: 愛媛大学, 医学(系)研究科(研究院), 講師 2009 – 2012: 愛媛大学, 大学院・医学系研究科, 講師 2007: Ehime University, Graduate School of Medicine, Senior Assistant Professor 2007: Ehime University, 大学院・医学系研究科, 講師 … More
Review Section/Research Field	Principal Investigator Applied pharmacology / Biological Sciences / Pathological medical chemistry Except Principal Investigator Biological Sciences / General medical chemistry / General medical chemistry
Keywords	Principal Investigator 悪性腫瘍 / HB-EGF / イメージング / 血管新生 / 血管内皮細胞 / VEGF / 発光イメージング / インビボイメージング / メッセンジャーRNA / 3'非翻訳領域 … More Except Principal Investigator Smad / BMP / TGF-β / HB-EGF / c-myc / Schnurri / PLZF / Shedding / DNAチップ / LIF / p300 / c-Ski / E1A / CTF / bFGF / EGF / PDGF / アクチビン / BMPII型レセプター / シグナル伝達と遺伝子発現 / 膜型増殖因子 / shedding / CTFシグナル / 転写リプレッサー / レトログレード小胞輸送 / HB-EGF-CTF / repressor / BCL6 / Bcl6 / 増殖因子 / 細胞増殖 / Transcriptional repressor / Pbx 1 / 小胞輸送 / 細胞増殖抑制 / ectodomian shedding / ADAM17 / proHB-EGF / proamphiregulin / proTNF-α / annexin / レムナントペプチドシグナル / amphiregulin / TNF-alpha / 細胞膜蛋白質 / Ectodomain Shedding / TNF-α / EIA / Shn / STAT / シグナル伝達 / 癌遺伝子 / 癌抑制遺伝子 / ユビキチン化 / 転写因子 / 血管新生 / ユビチキン化 / 受容体 / Smurf1 / Wntシグナル / シグナルクロストーク / がんの浸潤・転移 / signal transduction / oncogene / anti-oncogene / ubiquitination / transcription factor / angiogenesis / 細胞周期進行 / EGF-ファミリー / TGF-α / ampbiregulin / epiregulin / メタロプロテアーゼ / γ-セクレターゼ / cell cycle progression Less

Regulation of ectodomian shedding by ADAM17 and remnant signaling
- Principal Investigator
  
  HIGASHIYAMA Shigeki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University
ＨＢ－ＥＧＦ前駆体切断機構を利用したＳＨＥＤＤＩＮＧ活性可視化と腫瘍転移予測Principal Investigator
- Principal Investigator
  
  井上博文
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Visualization of angiogenesis in a mouse for evaluation of anti-angiogenesis drugsPrincipal Investigator
- Principal Investigator
  
  INOUE Hirofumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Ehime University
Isolation and Analysis of a transcriptional repressor to cause cardiac myopathyPrincipal Investigator
- Principal Investigator
  
  INOUE Hirofumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Ehime University
Functional analysis of the C-treminal frangment of membrane-anchored growth factors
- Principal Investigator
  
  HIGASHIYAMA Shigeki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Ehime University
Carboxy-ternminal fragment signaling of membrane-anchored growth factors the EGF family
- Principal Investigator
  
  HIGASHIYAMA Shigeki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University
BMPおよびアクチビンの細胞内シグナル伝達機構の解析
- Principal Investigator
  
  MASAHIRO Kawabata
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
Smadの転写調節機構
- Principal Investigator
  
  川畑正博
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Japanese Foundation For Cancer Research
Mechanisms of TGF-β signaling and its abnormalities in human cancer
- Principal Investigator
  
  MIYAZONO Kohei
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Signal transduction of the TGF-βsuperfamily and its disturbances.
- Principal Investigator
  
  MASAHIRO Kawabata
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Japanese Foundation for Cancer Research

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Patent

[Journal Article] Spaciotemporal visualisation of proHB-EGF ectodomain shedding in living cells2013
- Author(s)
  井上博文、坂上倫久、小澤岳昌、
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: ー
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23113512
[Journal Article] Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells.2013
- Author(s)
  H. Inoue, T. Sakaue, T. Ozawa and S. Higashiyama
- Journal Title
  
  J Biochem
  
  Volume: 154 Pages: 67-76
- DOI
  10.1093/jb/mvt030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21675001, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24659280
[Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin.2012
- Author(s)
  Hironao Nakayama
- Journal Title
  
  Mol. Biol. Cell.
  
  Volume: (印刷中) Pages: 1964-1975
- DOI
  10.1091/mbc.e11-08-0683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790319, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382, KAKENHI-PROJECT-24591628, KAKENHI-PROJECT-24591655, KAKENHI-PROJECT-24659280, KAKENHI-PUBLICLY-23112513
[Journal Article] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding.2012
- Author(s)
  Shinji Fukuda
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Pages: 315-20
- DOI
  10.1016/j.bbrc.2012.02.156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790319, KAKENHI-PROJECT-24390074, KAKENHI-PROJECT-24590382
[Journal Article] Activation of epidermal growth factor receptor gene is involved in transforming growth factor-beta-mediated fibronectin expression in a chondrocyte progenitor cell line.2010
- Author(s)
  Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H.
- Journal Title
  
  Int J Mol Med. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.2009
- Author(s)
  Uetani T, Nakayama H, Okayama H, Okura T, Higaki J, Inoue H, Higashiyama S.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 12399-12409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] Insufficiency of pro-heparin-binding epidermal growth factor-like growth factor shedding enhances hypoxic cell death in H9c2 cardiomyoblasts via the activation of caspase-3 and c-Jun N-terminal kinase.2009
- Author(s)
  Uetani T, Inoue H, Higashiyama S
- Journal Title
  
  J Biol Chem. 284(18)
  
  Pages: 12399-409
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression.2008
- Author(s)
  Nanba D, Inoue H, Higashiyama S
- Journal Title
  
  J Cell Physiol. 214(2)
  
  Pages: 465-73
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] Pbx1is a major target of PLZF-mediated melanoma cell growth suppression.2007
- Author(s)
  Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
- Journal Title
  
  Oncogene 26
  
  Pages: 339-348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390081
[Journal Article] Pbx1 is a major target of PLZF-mediated melanoma cell growth suppression.2007
- Author(s)
  Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
- Journal Title
  
  Oncogene 26
  
  Pages: 339-348
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] Pre-B-cell leukemia transcription factor 1 is a major target of promyelocytic leukemia zinc-finger-mediated melanoma cell growth suppression.2007
- Author(s)
  Shiraishi K, Inoue H, Higashiyama S
- Journal Title
  
  Oncogene 26(3)
  
  Pages: 339-48
- Data Source
  KAKENHI-PROJECT-17014068
[Journal Article] Pbxl is a major target of PLZF-mediated melanoma cell growth suppression.2007
- Author(s)
  Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., Higashiyama, S.
- Journal Title
  
  Oncogene 26
  
  Pages: 339-348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390081
[Patent] EGF受容体リガンド切断検知蛍光バイオセンサー2013
- Inventor(s)
  井上　博文、東山　繁樹
- Industrial Property Rights Holder
  井上　博文、東山　繁樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-007807
- Filing Date
  2013-01-18
- Data Source
  KAKENHI-PUBLICLY-23113512
[Patent] 新規ユビキチンリガーゼ及びその利用法2009
- Inventor(s)
  東山繁樹, 井上博文, 大貫秀隆
- Industrial Property Rights Holder
  国立大学法人愛媛大学
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-17014068
[Patent] 新規ユビキチンチガーゼ複合体及びその利用法2009
- Inventor(s)
  東山繁樹、井上博文、大貫秀隆
- Industrial Property Rights Holder
  愛媛大学
- Industrial Property Number
  2009-277073
- Filing Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-17014068
[Patent] 血管新生制御剤, 及びそのスクリーニング方法、並びにスクリーニング用キット2008
- Inventor(s)
  東山繁樹、井上博文、大貫秀隆
- Industrial Property Rights Holder
  国立大学法人愛媛大学
- Filing Date
  2008-08-14
- Data Source
  KAKENHI-PROJECT-17014068
[Presentation] 蛍光バイオセンサープローブを用いたＨＢ－ＥＧＦ前駆体切断イベントの可視化2013
- Author(s)
  井上博文、小澤岳昌、東山繁樹
- Organizer
  がん支援活動公開シンポジウム
- Place of Presentation
  学術総合センター（東京都）
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PUBLICLY-23113512
[Presentation] BAZF mRNA binding protein regulates mRNA stability of BAZF proangiogenic gene under a VEGF-A stimulation2012
- Author(s)
  井上博文
- Organizer
  北米血管生物学会年会
- Place of Presentation
  アメリカ合衆国ユタ州
- Year and Date
  2012-01-18
- Data Source
  KAKENHI-PROJECT-22590501
[Presentation] ZF50 mRNA binding protein regulates mRNA stability of proangiogenic genes under a VEGF-A stimulation2011
- Author(s)
  井上博文
- Organizer
  日本生化学会
- Place of Presentation
  日本京都
- Year and Date
  2011-10-24
- Data Source
  KAKENHI-PROJECT-22590501
[Presentation] A zinc finger transcription factor regulates vascular sprouting through the downregulation of Notch signaling in vascular endothelial cells.2009
- Author(s)
  Hidetaka Ohnuki, Hirofumi Inoue, Hironao Nakayama, Shinji Fukuda, Shigeki Higashiyama
- Organizer
  Keystone Symposia -Angiogenesis and Lymphangiogenesis in Cancer-
- Place of Presentation
  Big Sky Resort, Big Sky, Montana, USA (Hidetaka Ohnuki received Keystone Symposia Scholarship Award, NIH, National Cancer Institute Grant #1R13CA135834-01. )
- Data Source
  KAKENHI-PROJECT-17014068
[Presentation] Ectodomian shedding ofEGF family members-the molecular mechanism and the physiological roles-(Symposium)2008
- Author(s)
  Hirofulrn Inoue, Shigeki Higasluyama, et.al.
- Organizer
  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイラント (神戸)
- Data Source
  KAKENHI-PROJECT-17014068
[Presentation] Sheddingフィールド形成因子同定と増殖因子シグナル制御機構2007
- Author(s)
  中山寛尚、井上博文、東山繁樹
- Organizer
  第30回日本分子生物学会第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-17014068
[Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007
- Author(s)
  上谷晃由、井上博文、東山繁樹
- Organizer
  30回日本分子生物学学会年会・第80回日本生化学学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18590298
[Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007
- Author(s)
  上谷晃由、井上博文、大蔵隆文、檜垣實夫、東山繁樹
- Organizer
  第30回日本分子生物学会第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-17014068
[Presentation] Molecular Mechanism of cardiac cell death regulated by ectodomain Shedding of growth factor2007
- Author(s)
  Teruyoshi, Uetani, Hirofumi, Inoue, Shigeki, Higashiyama
- Organizer
  Biochemistry and Molecular Biology 2007
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590298
[Presentation] 増殖因子切断による心筋細胞死誘導制御の解析2007
- Author(s)
  上谷晃由、井上博文、東山繁樹
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590298

1. IMAMURA Takeshi (70264421)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HIGASHIYAMA Shigeki (60202272)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
3. MASAHIRO Kawabata (60224838)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KEN Yagi (10322637)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. HIEDA Miki (00380254)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 加藤光保 (20194855)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MORIMOTO Chie (10332826)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUDA Shinji (70398238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. MATSUSHITA Natsuki (40271556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. JHO Takashi (30231369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MIYAZAWA Keiji (40209896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. WATABE Tetsuro (00334235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAITOH Masao (90345041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 難波大輔 (10380255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. FUKUDA Hisayo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 橋本公二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 白方裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 小澤岳昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE Hirofumi 井上 博文

HIROFUMI Inoue 井上 博文

Research Projects

Research Products

Co-Researchers

Regulation of ectodomian shedding by ADAM17 and remnant signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ＨＢ－ＥＧＦ前駆体切断機構を利用したＳＨＥＤＤＩＮＧ活性可視化と腫瘍転移予測Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Visualization of angiogenesis in a mouse for evaluation of anti-angiogenesis drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation and Analysis of a transcriptional repressor to cause cardiac myopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of the C-treminal frangment of membrane-anchored growth factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Carboxy-ternminal fragment signaling of membrane-anchored growth factors the EGF family

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BMPおよびアクチビンの細胞内シグナル伝達機構の解析

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Smadの転写調節機構

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Mechanisms of TGF-β signaling and its abnormalities in human cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Signal transduction of the TGF-βsuperfamily and its disturbances.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Spaciotemporal visualisation of proHB-EGF ectodomain shedding in living cells2013

Author(s)

Journal Title

Data Source

[Journal Article] Spatiotemporal visualization of proHB-EGF ectodomain shedding in living cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell surface-annexins regulate ADAM-mediated ectodomain shedding of proamphiregulin.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding.2012

Author(s)

Journal Title

INOUE Hirofumi 井上博文

HIROFUMI Inoue 井上博文