Yokokawa Akitomo 横川彰朋

… Alternative Names

YOKOKAWA Akitomo 横川彰朋

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Researcher Number	70328558
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東京薬科大学, 薬学部, 講師 2012 – 2014: 東京薬科大学, 薬学部, 助教 2004 – 2006: 東京薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator 11β-HSD / 酵素活性 / 本態性高血圧 / 腎疾患 / 11β-HSD2 / コルチゾン / コルチゾール Except Principal Investigator GC-MS-SIM / hypertension / renal disease … More / cortisol ratio / urinary cortisone / 11β-activity / stable isotope methodology / cortisone / cortisol / 11β-HSD2酵素活性評価 / 安定同位体標識 / 速度論的解析 / 体内動態 / グリチルリチン酸 / 安定同位体標識体 / 11β-HSD2の酵素活性 / 腎疾患患者 / F比 / 尿中E / GC-MS分析 / コルチゾン / 11β-HSD2酵素活性 / コルチゾール Less

個別化薬物治療を目指した内因性物質による新規CYP1A2活性評価法の開発Principal Investigator
- Principal Investigator
  
  横川彰朋
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
The relationship between 11beta-hydroxysteroid dehydrogenase 2 enzyme activity and blood pressure in patients with renal diseasePrincipal Investigator
- Principal Investigator
  
  YOKOKAWA Akitomo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension
- Principal Investigator
  
  KASUYA Yasuji
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Sciences

All 2014 2013 2012 2005

All Journal Article Presentation

[Journal Article] Intraindividual and Interindividual Variabilities in Endogenous Cortisol 6β-Hydroxylation Clearance as an Index for In Vivo CYP3A Phenotyping in Humans2013
- Author(s)
  Hiromi Shibasaki, Kaori Hosoda, Mari Goto, Atsushi Suzuki, Akitomo Yokokawa, Kazuo Ishii, and Takashi Furuta
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 41 Issue: 2 Pages: 475-479
- DOI
  10.1124/dmd.112.048561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790172
[Journal Article] The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity2012
- Author(s)
  Akitomo Yokokawa, Toru Takasaka, Hiromi Shibasaki, Yasuji Kasuya, Soko Kawashima, Akira Yamada, and Takashi Furuta
- Journal Title
  
  Steroids
  
  Volume: 77 Issue: 12 Pages: 1291-1297
- DOI
  10.1016/j.steroids.2012.07.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790172
[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, S.Takashima, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-2
  
  Pages: 117-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005
- Author(s)
  Kasuya Y, Yokokawa A, Hamura K, Shibasaki H, Furuta T
- Journal Title
  
  Steroids 70・12
  
  Pages: 811-816
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005
- Author(s)
  Y.Kasuya, A.Yokokawa, K.Hamura, H.Shibasaki, T.Futruta
- Journal Title
  
  Steroids 70-12
  
  Pages: 811-816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590126
[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005
- Author(s)
  Kasuya Y, Yokokawa A, Takashima S, Furuta T, Shibasaki H
- Journal Title
  
  Steroids 70・2
  
  Pages: 117-125
- Data Source
  KAKENHI-PROJECT-16590126
[Presentation] LC-MS/MSによる尿中6α-および6β-ヒドロキシコルチゾールの安定同位体質量分析法の開発2014
- Author(s)
  横川彰朋，青野智恵美，柴崎浩美，細田香織，石井和夫，古田隆
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790172
[Presentation] ヒトin vivo における11β-HSD2 活性の日内・日間変動に関する研究2013
- Author(s)
  横川彰朋，柴崎浩美，細田香織，石井和夫，古田隆
- Organizer
  第53 回日本臨床化学会年次集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-24790172
[Presentation] Individual variability of cortisone/cortisol ratio correlated to the cortisol concentration in human urine as a new index for phenotyping in vivo 11β-hydroxysteroid dehydrogenase 2 activity2012
- Author(s)
  Akitomo Yokokawa, Hiromi Shibasaki, Takashi Furuta
- Organizer
  6th European Congress of Pharmacology
- Place of Presentation
  Granada, Spain
- Data Source
  KAKENHI-PROJECT-24790172
[Presentation] 尿量増加による尿中cortisone/cortisol比の変動とヒトin vivo 11β-HSD2酵素活性評価法2012
- Author(s)
  横川彰朋，柴崎浩美，古田隆
- Organizer
  第52 回日本臨床化学会年次集会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-24790172

1. FURUTA Takashi (70120152)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. SHIBASAKI Hiromi (20206121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. KASUYA Yasuji (90096686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 山田明

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 川嶋聡子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yokokawa Akitomo 横川 彰朋

YOKOKAWA Akitomo 横川 彰朋

Research Projects

Research Products

Co-Researchers

個別化薬物治療を目指した内因性物質による新規CYP1A2活性評価法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The relationship between 11beta-hydroxysteroid dehydrogenase 2 enzyme activity and blood pressure in patients with renal diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of in vivo enzymatic activity of cortisol metabolism associated with hypertension

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intraindividual and Interindividual Variabilities in Endogenous Cortisol 6β-Hydroxylation Clearance as an Index for In Vivo CYP3A Phenotyping in Humans2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Use of 11 a-deuterium labeled cortisol as a tracer for assessing reduced 11 β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Validation of the plasma half-life of 11α-deuterium cortisol as a sensitive indexr for the analysis of 11β-HSD2 activity in vivo.2005

Author(s)

Journal Title

Data Source

[Journal Article] Validation of the plasma half-life of 1la-deuterium cortisol as a sensitive index for the analysis of human 11β-HSD2 activity in vivo.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Use of 11α-deuterium labeled cortisol as a tracer for assessing reduced 11β-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject2005

Author(s)

Journal Title

Data Source

[Presentation] LC-MS/MSによる尿中6α-および6β-ヒドロキシコルチゾールの安定同位体質量分析法の開発2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ヒトin vivo における11β-HSD2 活性の日内・日間変動に関する研究2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Individual variability of cortisone/cortisol ratio correlated to the cortisol concentration in human urine as a new index for phenotyping in vivo 11β-hydroxysteroid dehydrogenase 2 activity2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 尿量増加による尿中cortisone/cortisol比の変動とヒトin vivo 11β-HSD2酵素活性評価法2012

Author(s)

Organizer

Place of Presentation

Data Source

Yokokawa Akitomo 横川彰朋

YOKOKAWA Akitomo 横川彰朋