Moriguchi Tomohisa 森口朋尚

… Alternative Names

MORIGUCHI Tomohisa 森口朋尚

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Researcher Number	70334133
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院理工学府, 准教授
Affiliation (based on the past Project Information) *help	2016: 群馬大学, 大学院理工学府, 准教授 2007: Gunma University, 大学院・工学研究科, 准教授 2005 – 2006: GUNMA UNIVERSITY, Chemistry, Associate Professor, 工学部, 助教授 2003 – 2004: 群馬大学, 工学部, 助手
Review Section/Research Field	Principal Investigator Chemistry related to living body Except Principal Investigator Bio-related chemistry / Chemistry related to living body
Keywords	Principal Investigator ペプチド核酸 / 分岐型核酸 / アンチセンス核酸 / 人工核酸 Except Principal Investigator 光励起電子移動 / 一塩基ミスマッチ / モレキュラービーコン / シリル化ペリレン / シリル化ピレン / 蛍光性オリゴDNA … More / functional chimera DNA / metal complex / pyrimidine-gap / diastereomer / novel non-nucleosidic component / alternate-stranded triplex / intercalator / α-β chimeric oligoDNA / 交叉型三重 / 融解温度 / アントラキノン / 熱安定性 / コンジュゲート / 亜リン酸化 / 交叉型三重鎖 / ビスヒロドキシプロピオン酸 / 機能性キメラDNA / 金属配位子 / ピリミジンギャップ / ジアステレオマー / 非ヌクレオシド性プラットホーム / 交差型三重鎖 / インターカレーター / キメラDNA Less

Development of fluorogenic probe for gene-analisis utilizing novel silylated fluorescent material
- Principal Investigator
  
  Shinozuka Kazuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Gunma University
RNAヘリカーゼ活性をもつ分岐状DNA-PNAハイブリッドアンチセンス核酸の開発Principal Investigator
- Principal Investigator
  
  森口朋尚
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Gunma University
Functionalization of oligonucleotides capable to form alternate-stranded triplex containing stereoisomeric nucleotide units
- Principal Investigator
  
  SHINOZUKA Kazuo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Gunma University

All 2017 2016 2015 2014 2008 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Pseudo-Dumbbell Type Molecular Beacon Probes bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore2015
- Author(s)
  Jakir Ahmed Chowdhury, Tomohisa Moriguchi, Kazuo Shinozuka,
- Journal Title
  
  Bull. Chem. Soc. Jpn.
  
  Volume: 88 Pages: 496-502
- NAID
  130004801842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26410173
[Journal Article] Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA2015
- Author(s)
  Tomohisa Moriguchi, Satomi Hida, Fumio Yoneda and Kazuo Shinozuka,
- Journal Title
  
  Aust. J. Chem.
  
  Volume: 68 Issue: 12 Pages: 256-259
- DOI
  10.1246/cl.140805
- NAID
  130004693836
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26410173
[Journal Article] Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5'-Terminus2015
- Author(s)
  T.Moriguchi, D. Moki, T. Sekiguchi, T. Kato, K. Shinozuka
- Journal Title
  
  Chem. Lett
  
  Volume: 44 Issue: 1 Pages: 44-46
- DOI
  10.1246/cl.140800
- NAID
  130004701543
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26410173
[Journal Article] Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5'-Terminus2014
- Author(s)
  Jakir Ahmed Chowdhury, Tomohisa Moriguchi, Kazuo Shinozuka,
- Journal Title
  
  Chem Lett.
  
  Volume: 44 Issue: 2 Pages: 44-46
- DOI
  10.1071/ch14477
- NAID
  130004701543
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26410173
[Journal Article] Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3'-Methanodeoxyuridine2008
- Author(s)
  Tomohisa Moriguchi
- Journal Title
  
  Chemistry Letters 37(印刷中)
- NAID
  10021080653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis2006
- Author(s)
  森口朋尚
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages: 187-188
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2, 2-bis (hydroxymethyl)propionic acid/anthraquinone/polyamine exhibited improved and stereo-nonspecific triplex-forming ability.2006
- Author(s)
  A.T.M.Z.Azam, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Chemical Communications
  
  Pages: 335-337
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid/anthraquinone/polyamine exhibited improved and stereononspecific triplex-forming ability.2006
- Author(s)
  A.T.M.Z.Azam, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Chemical Communications
  
  Pages: 335-337
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position2006
- Author(s)
  森口朋尚
- Journal Title
  
  Nucleosides Nucleotides Nucleic Acids 25
  
  Pages: 601-612
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability2006
- Author(s)
  森口朋尚
- Journal Title
  
  Chem.Commun.
  
  Pages: 335-337
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Novel fluorescent oligo-DNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher2006
- Author(s)
  森口朋尚
- Journal Title
  
  Bioorg.Med.Chem.Lett. 16
  
  Pages: 2685-2688
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA2006
- Author(s)
  森口朋尚
- Journal Title
  
  Protein Peptide Lett 13
  
  Pages: 417-419
- Data Source
  KAKENHI-PROJECT-18750142
[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid/anthraquinone/polyamine exhibited improved and stereo-nonspecific triplex-forming ability2006
- Author(s)
  A.T.M.Z.Azam, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Chemical Communications
  
  Pages: 335-337
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified α-β chimeric DNA2005
- Author(s)
  T.Moriguchi, A.T.M.Z.Azam, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res. Sym. Ser., 49
  
  Pages: 7-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified α-β chimeric DNA2005
- Author(s)
  T.Moriguchi, A.T.M.Z.Azam, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 49
  
  Pages: 7-8
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triple helix forming ability of novel anthraquinone modified α-β chimeric DNA.2005
- Author(s)
  T.Moriguchi, A.T.M.Z.Azam, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 49
  
  Pages: 7-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triplex forming ability of novel α-β chimeric oligonucleotides bearing an intercalator-conjugated nucleobase.2004
- Author(s)
  A.T.M.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res. Sym. Ser., 48
  
  Pages: 207-208
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] α-β chimeric oligcDNA bearing intercalator-conjugated nucleoside inside the linker sequence remarkably inproves thermal stability of an alternate-stranded triple helix.2004
- Author(s)
  A.T.M.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 14
  
  Pages: 5747-5750
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triplex forming ability of novel α-β chimeric oligonucleotides bearing an intercalator-conjugated nucleobase.2004
- Author(s)
  A.T.M.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 48
  
  Pages: 207-208
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] α-βChimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix2004
- Author(s)
  ATM.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 5747-5750
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphotriester linkage facilitates triplex formation with dsDNA. bearing a Pyrimidine-gapped polypurine sequence.2004
- Author(s)
  M.Sato, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 14
  
  Pages: 1305-1308
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] α-β chimeric oligoDNA bearing intercalator-conjugated nucleoside inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix.2004
- Author(s)
  A.T.M.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 14
  
  Pages: 5747-5750
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Synthesis and alternate-stranded triplex forming ability of novel α-βchimeric oligonucleotides bearing an intercalator-conjugated nucleobase2004
- Author(s)
  ATM.Z.Azam, M.Hasegawa, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Nucleic Acids Res.Sym.Ser. 48
  
  Pages: 207-208
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Novel anthraquinone conjugate of 2,2-bis(hydroxymethyl)propionic acid incorporated to a TFO with phosphotriester linkage facilitates triplex formation with dsDNA bearing a Pyrimidine-gapped polypurine sequence.2004
- Author(s)
  M.Sato, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 14
  
  Pages: 1305-1308
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Novel dinucleoside phosphotriester unit conjugated with an intercalator moiety in a Stereospecific manner enhances thermal stability of an alternate-stranded triple helix.2003
- Author(s)
  T.Miyashita, N.Matsumoto, T.Moriguchi, K.Shinozuka
- Journal Title
  
  Tetrahedron Letters 44
  
  Pages: 7399-7402
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Journal Article] Novel dinucleoside phosphotriester unit conjugated with an intercalator moiety in a Stereospecific manner enhances thermal stability of an alternate-stranded triple helix.2003
- Author(s)
  T.Miyashita, N.Matsumoto, T.Moriguchi, K..Shinozuka
- Journal Title
  
  Tetrahedron Letters 44
  
  Pages: 7399-7402
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15550144
[Presentation] 短鎖オリゴマーを用いたモレキュラービーコンプローブの配列識別能の向上2017
- Author(s)
  川崎昌和、森口朋尚、篠塚和夫
- Organizer
  日本化学会第97春季年会
- Place of Presentation
  東京
- Year and Date
  2017-03-16
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] 高リスク型HPV検出用モレキュラービーコンの開発2016
- Author(s)
  入江勇輔、森口朋尚、篠塚和夫
- Organizer
  第2回核酸医薬学会
- Place of Presentation
  東京
- Year and Date
  2016-11-15
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] ダンベル型構造を形成するデコイ核酸の熱安定性及び酵素耐性2016
- Author(s)
  佐藤華苗、森口朋尚、篠塚和夫
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都府京田辺市　同志社大学
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] Development of Dumbbell-Shaped Molecular Beacon Probes Bearing Diphenylsilylated Pyrene2016
- Author(s)
  T. Moriguchi, R. Nakayama, D. Moki, and K. Shinozuka
- Organizer
  The 43rd International Symposium of Nucleic Acids Chemistry
- Place of Presentation
  KUMAMOTO
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] Development of Convenient Genotyping of High-Risk HPV using Fluorescence DNA Probes2016
- Author(s)
  Y. Irie, K. Shinozuka, T. Sano, T. Moriguchi
- Organizer
  The 3rd International Symposium of Gunma University Medical Innovation
- Place of Presentation
  KIRYU
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] 高リスク型HPVモレキュラービーコンプローブの開発2016
- Author(s)
  入江勇輔、森口朋尚、篠塚和夫
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都府京田辺市　同志社大学
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] シリル化シアノピレンを導入したモレキュラービーコンプローブの開発2016
- Author(s)
  時田和樹・森口朋尚・篠塚和夫
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  京都府京田辺市　同志社大学
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] ジフェニルシリルピレンを導入したダンベル型モレキュラービーコンの開発2015
- Author(s)
  森口朋尚、中山綾平、篠塚和夫
- Organizer
  日本核酸医薬学会第1回年会
- Place of Presentation
  京都府　京都テルサ
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] Development of Molecular Beacon Probes for High-Risk HPV Genotyping2015
- Author(s)
  Yusuke Irie, Tomohisa Moriguchi, Kazuo Shinozuka
- Organizer
  The 5th International Symposium on Element Innovation
- Place of Presentation
  Kiryu, Japan
- Year and Date
  2015-11-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] Synthesis and fluorescence property of the modified oligonucleotides containing silylated cyanopyrene derivatives2014
- Author(s)
  Satomi Hida, Tomohisa Moriguchi, Kazuo Shinozuka
- Organizer
  The 4th International Symposium on Element Innovation
- Place of Presentation
  Kiryu, Japan
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] シリル化ピレンで標識化された人工DNAの合成と性質2008
- Author(s)
  森口朋尚
- Organizer
  日本化学会第88春季年会
- Place of Presentation
  東京・立教大学
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18750142
[Presentation] Development of novel quencher free fluorescent oligoDNA probe utilizing silylated pyrene as a fluorophore
- Author(s)
  Jakir Ahmed Chowdhury, Tomohisa Moriguchi, Kazuo Shinozuka
- Organizer
  The 41st International Symposium on Nucleic Acid Chemistry
- Place of Presentation
  Kitakyushu, Japan
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PROJECT-26410173
[Presentation] 新規シリル化ピレン誘導体およびこれを導入した蛍光プローブの開発
- Author(s)
  飛田怜実、森口朋尚、篠塚和夫
- Organizer
  アンチセンス・遺伝子・デリバリーシンポジウム2014
- Place of Presentation
  東京
- Year and Date
  2014-09-08 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-26410173

1. SHINOZUKA Kazuo (20206105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
2. 井上裕介 (90304302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Jakir Ahmed Chowdury

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KAWASAKI Masakazu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. IRIE Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. HIDA Satomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. MOKI Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. TOKITA Kazuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Moriguchi Tomohisa 森口 朋尚

MORIGUCHI Tomohisa 森口 朋尚

Research Projects

Research Products

Co-Researchers

Development of fluorogenic probe for gene-analisis utilizing novel silylated fluorescent material

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RNAヘリカーゼ活性をもつ分岐状DNA-PNAハイブリッドアンチセンス核酸の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functionalization of oligonucleotides capable to form alternate-stranded triplex containing stereoisomeric nucleotide units

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pseudo-Dumbbell Type Molecular Beacon Probes bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Synthesis and Spectroscopic Properties of a Novel Bifunctional Pyrene Derivative and its Incorporation into OligoDNA2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5'-Terminus2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis and Properties of Novel Fluorescently Labeled Oligonucleotides Possessing Silylated Pyrene at the 5'-Terminus2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3'-Methanodeoxyuridine2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Development of DNA-intercalator-polyamine multi-conjugate bearing the ability of the sequence-specific RNA hydrolysis2006

Author(s)

Journal Title

Data Source

[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2, 2-bis (hydroxymethyl)propionic acid/anthraquinone/polyamine exhibited improved and stereo-nonspecific triplex-forming ability.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid/anthraquinone/polyamine exhibited improved and stereononspecific triplex-forming ability.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and duplex-forming property of oligonucleotides bearing a novel polyamine-modified intercalator at the terminal or the internal position2006

Author(s)

Journal Title

Data Source

[Journal Article] Modified α-β chimeric oligoDNA bearing a multi-conjugate of 2,2-bis(hydroxymethyl)propionic acid-anthraquinone-polyamine exhibited improved and stereo-nonspecific triplex-forming ability2006

Author(s)

Journal Title

Data Source

[Journal Article] Novel fluorescent oligo-DNA probe bearing a multi-conjugated nucleoside with a fluorophore and a non-fluorescent intercalator as a quencher2006

Author(s)

Journal Title

Data Source

[Journal Article] Crystallization and preliminary X-ray crystallographic analysis of yeast tyrosyl-tRNA synthetase complexed with its cognate tRNA2006

Author(s)

Journal Title

Moriguchi Tomohisa 森口朋尚

MORIGUCHI Tomohisa 森口朋尚