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MIZUNO Tetsuya  水野 哲也

ORCIDConnect your ORCID iD *help
Researcher Number 70335008
Other IDs
Affiliation (based on the past Project Information) *help 2015: 名古屋大学, 環境医学研究所, 客員准教授
2012 – 2014: 名古屋大学, 環境医学研究所, 准教授
2007 – 2008: Nagoya University, 環境医学研究所, 准教授
2006: 名古屋大学, 環境医学研究所, 助教授
2004: Nagoya University, Research Institute of Environmental Medicine, Associate Professor, 環境医学研究所, 助教授
2003: 名古屋大学, 環境医学研究所, 助手
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology
Keywords
Principal Investigator
ミクログリア / CpG / 脳移行性ペプチド / RVG-CPG / 機能性ペプチド核酸 / アルツハイマー病 / 神経保護作用 / TGF / IL-34 / 神経免疫 … More / 脳神経疾患 / 調節性T細胞 / 炎症性脱髄 / ミッドカイン … More
Except Principal Investigator
neuronal degeneration / cytokine / multiple sclerosis / microglia / 神経変性 / サイトカイン / 多発性硬化症 / ミクログリア Less
  • Research Projects

    (4 results)
  • Research Products

    (50 results)
  • Co-Researchers

    (2 People)
  •  Treatment for Alzheimer disease by CpG with RVGPrincipal Investigator

    • Principal Investigator
      Mizuno Tetsuya
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  Induction of regulatory microglia and its therapeutic developmentPrincipal Investigator

    • Principal Investigator
      MIZUNO Tetsuya
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  The role of midkine family in inflammatory demyelinationPrincipal Investigator

    • Principal Investigator
      MIZUNO Tetsuya
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University
  •  The role of microglia on the development of neurological disorders

    • Principal Investigator
      SUZUMURA Akio
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Nagoya University

All 2015 2014 2013 2012 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia2015

    • Author(s)
      Parajuli B, Horiuchi H, Mizuno T, Takeuchi H, Suzumura A
    • Journal Title

      Glia

      Volume: 63 Issue: 12 Pages: 2274-84

    • DOI

      10.1002/glia.22892

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26670441
  • [Journal Article] FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway.2014

    • Author(s)
      Mariko Noda, Kento Takii, Bijay Parajuli, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of Neuroinflammation

      Volume: 11(1) Issue: 1 Pages: 76-76

    • DOI

      10.1186/1742-2094-11-76

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-26670441
  • [Journal Article] GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia.2013

    • Author(s)
      Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura
    • Journal Title

      Journal of Neuroinflammation

      Volume: 9(1) Issue: 1 Pages: 268-268

    • DOI

      10.1186/1742-2094-9-268

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24659430
  • [Journal Article] Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease.2013

    • Author(s)
      B Parajuli, Y Sonobe, H Horiuchi, H Takeuchi, T Mizuno, A Suzumura
    • Journal Title

      Cell Death & Disease

      Volume: 4 Issue: 12 Pages: e975-e975

    • DOI

      10.1038/cddis.2013.503

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24111520, KAKENHI-PROJECT-24659430
  • [Journal Article] The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity.2012

    • Author(s)
      Li E, Noda M, Doi Y, Parajuli B, Kawanokuchi J, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A.
    • Journal Title

      Journal of neuroinflamation

      Volume: 9 Pages: 148-148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Journal Article] TGF-β induced by interleukin-34-stimulated microglia regulates microglial proliferation and attenuates oligomeric amyloid β neurotoxicity2012

    • Author(s)
      Ma D, Doi Y, Jin S, Li E, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A
    • Journal Title

      Neuroscience Letters

      Volume: 529(1) Issue: 1 Pages: 86-91

    • DOI

      10.1016/j.neulet.2012.08.071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591258, KAKENHI-PROJECT-24659430, KAKENHI-PUBLICLY-24111520
  • [Journal Article] The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloidβtoxicity2012

    • Author(s)
      Li E, Noda M, Doi Y, Parajuli B, Kawanokuchi J, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A.
    • Journal Title

      Journal of neuroinflamation

      Volume: 9(1186/1742-2094-9-148) Pages: 148-148

    • Data Source
      KAKENHI-PROJECT-24659430
  • [Journal Article] Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity2008

    • Author(s)
      Liang J, Mizuno T, Suzumura A 他(11人10番目)
    • Journal Title

      Brain Research 1210

      Pages: 11-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Microglia express a functional receptor for interleukin-23.2008

    • Author(s)
      SONOBE Yoshifumi, MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      Biochemical and Biophysical Research Communic ations. 370

      Pages: 129-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Interferon-γ directly induces neurotoxicity through a neuron specific, calciumpermeable complex of IFN-γ receptor and AMPA GluR1 receptor.2008

    • Author(s)
      MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      FASEB Journal 22

      Pages: 1797-1806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Production and functions of IL-17 in microglia2008

    • Author(s)
      Kawanokuchi J, Mizuno T, Suzumura A 他(7人5番目)
    • Journal Title

      Journal of Neuroimmunology 194

      Pages: 54-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Microglia express a functional receptor for interleukin-232008

    • Author(s)
      Sonobe Y, Mizuno T, Suzumura A 他(7人6番目)
    • Journal Title

      Biochemical and Biophysical Research Communications 370

      Pages: 129-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalo- myelitis through the expansion of regulatory T cell population2008

    • Author(s)
      Wang J, Takeuchi H, Sonobe Y, Mizuno T 他(12人5番目)
    • Journal Title

      Proc Natl Acad Sci U S A 105

      Pages: 3915-3920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Excitatory amino acid transporter expression by astrocytes is neuroprotective against microglial excitotoxicity.2008

    • Author(s)
      LIANG Jianfeng, MIZUNO Tetsuya, SUZUMURA Akio
    • Journal Title

      Brain Research 1210

      Pages: 11-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Interferon-. directly induces neurotoxicity through a neuron specific, calcium- permeable complex of IFN- receptor and AMPA GluR1 receptor2008

    • Author(s)
      Mizuno T, Suzumura A 他(10人1番目)
    • Journal Title

      FASEB Journal 22

      Pages: 1797-1806

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell2008

    • Author(s)
      Wang J, Takeuchi H. Sonobe Y. Mizuno T.
    • Journal Title

      Proceedings of the National Academy of Sciences USA 105

      Pages: 3915-3920

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Production and functions of IL-17 in microglia.2008

    • Author(s)
      Kawanokuchi J, Mizuno T, Suzumura A,
    • Journal Title

      Journal of Neuroimmunology 194

      Pages: 54-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Chronological changes of CD8-T cell subsets in the cxperimental auloimmune eneephalomvelilis, a mouse model of multiple2007

    • Author(s)
      Sonobe Y, Jin S, Takeuchi H, Mizuno T,
    • Journal Title

      Tohoku Journal of Experimental Medicine 213

      Pages: 329-339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Chronological changes of CD4+ and CD8+ T cell subsets in the experimental autoimmune encephalo- myelitis, a mouse model of multiple sclerosis2007

    • Author(s)
      Sonobe Y, Jin S, Takeuchi H, Mizuno T 他(7人6番目)
    • Journal Title

      Tohoku Journal of Experimental Medicine 213

      Pages: 329-339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Production of interferon-γby microglia.2006

    • Author(s)
      Kawanokuchi J, Mizuno T, Takeuchi H, Kato H, Wang J, Mitsuma N, Suzumura A
    • Journal Title

      Multiple Sclerosis 12

      Pages: 558-564

    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Role of glia-derived cytokines on neuronal degeneration and regeneration2006

    • Author(s)
      Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T
    • Journal Title

      Annals of New York Academy of Science 1088

      Pages: 219-229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Production of interferon-2006

    • Author(s)
      Kawanokuchi J, Mizuno T, Takeuchi H, Kato H, Wang J, Mitsuma N, Suzumura A
    • Journal Title

      by microglia Multiple Sclerosis 12

      Pages: 558-564

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Midkine deficiency protects against Experimental Autoimmnue Encephalomyelitis by expansion of CD4^+CD25^+Foxp3^+ regulatory T cells.2006

    • Author(s)
      Wwng J, Takeuchi H, Jin S, Sonobe Y, Mizuno T, Muramatsu H, Muramatsu T, Suzumura A
    • Journal Title

      Journal of Neuroimmunology 178

      Pages: 169-169

    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] Role of glia-derived cytokines on neuronal degeneration and regeneration.2006

    • Author(s)
      Suzumura A, Takeuchi H, Zhang G, Kuno R, Mizuno T
    • Journal Title

      Annals of New York Academy of Science 1088

      Pages: 219-229

    • Data Source
      KAKENHI-PROJECT-18590933
  • [Journal Article] The radical scavenger edaravone prevents oxidative neurotoxicity by peroxynitrite and by activated microglia.2005

    • Author(s)
      Banno, M., Mizuno, T., Kato, H., Zang, G., Kawanokuchi, J., Kuno, R., Jin, S., Takeuchi, H., Suzumura, A.
    • Journal Title

      Neuropharmacol. 48

      Pages: 283-290

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Autocrine activation of microglia by tumor necrosis factor-α.2005

    • Author(s)
      Kuno, R., Wang, J., Kawanokuchi, J., Takeuchi, H., Mizuno, T., Suzumura, A.
    • Journal Title

      J.Neuroimmunol 162

      Pages: 89-96

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] The radical scavenger edaravone prevents oxidative neurotoxicity by peroxynitrite and by activated microglia.2005

    • Author(s)
      Banno, M., Mizuno, T., Kato, H., Zang, G., Suzumura.A.
    • Journal Title

      Neuropharmacol. 48

      Pages: 283-290

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Autocrine activation of microglia by tumor necrosis factor-α.2005

    • Author(s)
      Kuno, R., Wang, J., Kawanokuchi, J., Takeuchi, H., Mizuno, T., Suzumura, A.
    • Journal Title

      J Neuroimmunol. 162

      Pages: 89-96

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations.2005

    • Author(s)
      Sonobe, Y., Yawata, I., Kawanokuchi, J., Takeuchi, H., Mizuno, T., Suzumura, A.
    • Journal Title

      Brain Res. 1040

      Pages: 202-207

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport.2005

    • Author(s)
      Takeuchi, H., Mizuno T, Zhang G, Wang J, Kawanokuchi J, Kuno R, Suzumura A.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 10444-10454

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) ameliorates experimental autoimmune encephalomyelitis2004

    • Author(s)
      Kato, H., Ito, A., Jin, S., Mizuno, T., Suzumura, A.
    • Journal Title

      Multiple Scler. 10

      Pages: 651-659

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia.2004

    • Author(s)
      Mizuno, T., Kurotani, T., Komatsu, Y., Kawanokuchi, J., Kato, H., Mits
    • Journal Title

      Neuropharmacol. 46

      Pages: 404-411

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide(PACAP) ameliorates experimental autoimmune encephalomyelitis2004

    • Author(s)
      Kato, H., Ito, A., Jin, S., Mizuno, T., Suzumura, A.
    • Journal Title

      Multiple Scler. 10

      Pages: 651-659

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia.2004

    • Author(s)
      Mizuno, T., Kurotani, T., Komatsu, Y., Kawanokuchi, J., Kato, H., Mitsuma, N., Suzumura, A.
    • Journal Title

      Neuropharmacol. 46

      Pages: 404-411

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Effects of interferon-β on microglial functions as inflammatory and antigen presenting cells in the central nervous system.2004

    • Author(s)
      Kawanokuchi, J., Mizuno, T., Kato, H., Mitsuma, N., Suzumura, A.
    • Journal Title

      Neuropharmacol. 46

      Pages: 734-742

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Effects of interferon-on microglial functions as inflammatory and antigen presenting cells in the central nervous system.2004

    • Author(s)
      Kawanokuchi, J., Mizuno, T., Kato, H., Mitsuma, N., Suzumura, A.
    • Journal Title

      Neuropharmacol. 46

      Pages: 734-742

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Phosphodiesterase inhibitors suppress IL-12 production with microglia and T helper 1 development.2003

    • Author(s)
      Suzumura, A., Ito.A, Mizuno, T.
    • Journal Title

      Multiple Scler. 9

      Pages: 574-578

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Production and neuroprotective functions of fractalkine in the central nervous system.2003

    • Author(s)
      Mizuno, T., Kawanokuchi, J., Numata, K., Suzumura, A.
    • Journal Title

      Brain Res. 979

      Pages: 65-70

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Phosphodiesterase inhibitors suppress IL-12 production with microglia and T helper 1 development.2003

    • Author(s)
      Suzumura, A., Ito, A., Mizuno, T.
    • Journal Title

      Multiple Scler. 9

      Pages: 574-578

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Journal Article] Production and neuroprotective functions of fractalkine in the central nervous system2003

    • Author(s)
      Mizuno, T., Kawanokuchi, J., Numata, K., Suzumura, A.
    • Journal Title

      Brain Res. 979

      Pages: 65-70

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590886
  • [Presentation] 可溶性Aβオリゴマーによるミクログリアの神経傷害作用.2013

    • Author(s)
      Parajuli B, 水野哲也
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] アルツハイマー病の慢性炎症機序におけるミクログリアの役割2013

    • Author(s)
      水野哲也
    • Organizer
      第32回日本認知症学会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] 可溶性Aβオリゴマーによるミクログリアの神経傷害作用2013

    • Author(s)
      PARAJULI Bijay、水野哲也、竹内英之、錫村明生
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      (下関)(口演)
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] The neuroprotective role of microglia treated with MFG-E82012

    • Author(s)
      Tetsuya Mizuno
    • Organizer
      11th International Congress of Neuroimmunology
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] Milk fat globule-EGF factor 8のAbeta神経毒性に対する作用の検討2012

    • Author(s)
      水野哲也、野田万理子、土井由紀子、錫村明生
    • Organizer
      第53回神経学会学術集会
    • Place of Presentation
      (東京)(ポスター)
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] The neuroprotective role of microglia treated with milk fat globule-EGF factor 82012

    • Author(s)
      MIZUNO Tetsuya, NODA Mariko, LI Endong, DOI Yukiko, PARAJULI Bijay, KAWANOKUCHI Jun, SONOBE Yoshifumi, TAKEUCHI Hideyuki, SUZUMURA Akio
    • Organizer
      11th International Congress of Neuroimmunology
    • Place of Presentation
      (Boston, USA) (ポスター)
    • Data Source
      KAKENHI-PROJECT-24659430
  • [Presentation] 中枢神経系におけるインターロイキン-25の発現とその機能2008

    • Author(s)
      片岡邦夫、水野哲也、錫村明生
    • Organizer
      第20回神経免疫学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Presentation] 中枢神経系におけるインクーロイキン-25の発現とその機能2008

    • Author(s)
      片岡邦夫, 水野哲也, 錫村明生
    • Organizer
      第20回神経免疫学会学術集会
    • Place of Presentation
      新潟
    • Year and Date
      2008-04-17
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Presentation] Midkine欠損マウスでは制御性T細胞の増加によりEAEの発症が抑制される2006

    • Author(s)
      竹内英之、王金岩、水野哲也、錫村明生
    • Organizer
      第47回日本神経学会総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-11
    • Data Source
      KAKENHI-PROJECT-18590933
  • [Presentation] 可溶性Abetaオリゴマーによるミクログリアの慢性神経炎症作用

    • Author(s)
      水野哲也、Bijay Parajuli、竹内英之、錫村明生
    • Organizer
      日本神経学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-23
    • Data Source
      KAKENHI-PROJECT-26670441
  • 1.  SUZUMURA Akio (50196896)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 31 results
  • 2.  竹内 英之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results

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