TOKUNAGA Chiharu 徳永千春

Researcher Number	70335462
External Links
Affiliation (based on the past Project Information) *help	2002 – 2004: Kobe University, Biosignal Research Center, Assistant Professor, バイオシグナル研究センター, 助手
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Biological Sciences / Pathological medical chemistry / Functional biochemistry / Functional biochemistry
Keywords	Principal Investigator TOS motif / raptor / 4EBP1 / p70 S6 kinase / AMPK / mTOR / energy metabolic sensor / nutrient sensor / Kog1 / リン酸化 / rapamycin / エネルギー代謝センサー / 栄養環境センサー … More Except Principal Investigator … More mTOR / raptor / p70 S6 kinase / rapamycin / 細胞成長 / cell growth / アミノ酸 / Rapamycin / スキャフォールド蛋白質 / 栄養環境 / FKBP12 / ラパマイシン / PRAS40 / TSC / 質量分析 / 細胞環境 / 抗がん剤 / 質量分析計 / amino acids / side effect / restenosis prevention / immunosuppressant / 血小板現象 / 中性脂肪上昇 / 創傷治癒遅延 / タンパク質リン酸化 / 創傷治癒 / 血小板減少 / 4EBP1 / mTOR複合体 / リン酸化 / 副作用 / 再狭窄阻害 / 免疫抑制剤 / heat shock protein 90 / pyrimidine biosynthesi / tuberous sclerosis / amino acid / mass spectrometry / rapter / Hsp90 / 核酸新生 / scaffold protein / TOS motif / elF4E binding protein / 蛋白合成 / scaffold蛋白 / p70S6キナーゼ / Scaffold蛋白質 / TOSモチーフ / eIF4E結合蛋白質 / AMP-activated protein kinase / Rheb / RNA翻訳制御 / 細胞成長制御 / ノックアウト / 翻訳後修飾 / プロテオーム解析 / mLST8 Less

アミノ酸情報感知伝達システムを担う分子情報の集積と構築
- Principal Investigator
  
  米澤一仁
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
がん抑制遺伝子TSCとGTP結合蛋白Rhebの制御をうけるmTORシグナルの研究
- Principal Investigator
  
  米澤一仁
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Study on the Mammalian target of rapamycin in thrombocytepoiesis, wound healing, and hyperlipemia
- Principal Investigator
  
  YOSHINO Ken-ichi, 米澤一仁
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
細胞成長システム制御因子分子情報の集積と構築
- Principal Investigator
  
  米澤一仁
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
がん抑制遺伝子TSCに制御されるラパマイシン標的蛋白mTORシグナルの研究
- Principal Investigator
  
  米澤一仁
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
RNA翻訳制御スイッチとして働くラパマイシン標的蛋白mTORシグナルの研究
- Principal Investigator
  
  米澤一仁
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Molecular Mining and Functional Analysis of Cell Growth Control System
- Principal Investigator
  
  YOSHINO Ken-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
"Research of crosstalk between nutrient sensing mTOR signaling pathway and energy metabolic sensing AMPK"Principal Investigator
- Principal Investigator
  
  TOKUNAGA Chiharu
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
哺乳細胞において細胞成長を司るシグナル伝達分子群のプロテオーム解析と機能同定
- Principal Investigator
  
  YONEZAWA Kazuyoshi
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Studies on molecular mechanism of mTOR signaling that controls various cellular functions in response to amino acid sufficiency.
- Principal Investigator
  
  YONEZAWA Kazuyoshi, 原賢太
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University

All 2006 2004 2003

All Journal Article Book Patent

[Book] 糖尿病学 20032003
- Author(s)
  徳永千春
- Total Pages
  168
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-15570116
[Book] 糖尿病学20032003
- Author(s)
  徳永千春
- Total Pages
  168
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-15030228
[Book] 糖尿病学 20032003
- Author(s)
  徳永千春
- Total Pages
  168
- Publisher
  診断と治療社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size2006
- Author(s)
  Eguchi, S., Tokunaga, C., Hidayat, S., Oshiro, N., Yoshino, K., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  Genes Cells 11 (7)
  
  Pages: 757-766
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin2006
- Author(s)
  Ohji, G., Hidayat, S., Nakashima, A., Tokunaga, C., Oshiro, N., Yoshino, K., Yokono, K., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  J. Biochem. 139 (1)
  
  Pages: 129-135
- NAID
  10018848648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] ラパマイシン標的タンパク質mTORシグナル伝達系2004
- Author(s)
  徳永千春
- Journal Title
  
  細胞工学 23・3
  
  Pages: 340-348
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] ラパマイシン標的タンパク質mTORシグナル伝達系2004
- Author(s)
  徳永千春
- Journal Title
  
  細胞工学 23・3
  
  Pages: 340-348
- Data Source
  KAKENHI-PROJECT-15030228
[Journal Article] ラパマイシン標的タンパク質mTORシグナル伝達系2004
- Author(s)
  徳永千春
- Journal Title
  
  細胞工学 23
  
  Pages: 340-348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Tokunaga, C.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313・2
  
  Pages: 443-446
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function2004
- Author(s)
  Oshiro, N., Yoshino, K., Hidayat, S., Tokunaga, C., Hara, K., Eguchi, S., Avruch, J., Yonezawa, K.
- Journal Title
  
  Genes Cells 9 (4)
  
  Pages: 359-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Tokunaga, C.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313・2
  
  Pages: 443-446
- Data Source
  KAKENHI-PROJECT-15030228
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313-2
  
  Pages: 443-446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] ラパマイシン標的タンパク質mTORシグナル伝達系2004
- Author(s)
  徳永千春
- Journal Title
  
  細胞工学 23(3)
  
  Pages: 340-348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Tokunaga, C.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313
  
  Pages: 443-446
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] Mammalian Target of Rapamycin (mTOR) Signaling System.2004
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Cell Technol. 23-3
  
  Pages: 340-348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] mTOR integrates amino acid-and energy-sensing pathways.2004
- Author(s)
  Tokunaga, C.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313・2
  
  Pages: 443-446
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Tokunaga, C.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313・2
  
  Pages: 443-446
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] mTOR integrates amino acid- and energy-sensing pathways.2004
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Biochem.Biophys.Res.Commun. 313-2
  
  Pages: 443-446
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] ラパマイシン標的タンパク質mTORシグナル伝達系2004
- Author(s)
  徳永千春
- Journal Title
  
  細胞工学 23・3
  
  Pages: 340-348
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] Mammalian Target of Rapamycin (mTOR) Signaling System.2004
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Cell Technol. 23-3
  
  Pages: 340-348
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Journal Article] 診断と治療性2003
- Author(s)
  徳永千春
- Journal Title
  
  糖尿病学2003
  
  Pages: 168-168
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] mTOR signaling network and insulin action2003
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Tonyobyogaku 2003
  
  Pages: 21-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570116
[Journal Article] Amino san-mTOR-raptor Sigunaru Dentatsukei no Kaimei to Insulin Sayo.2003
- Author(s)
  Chiharu, Tokunaga
- Journal Title
  
  Tonyobyogaku 2003
  
  Pages: 21-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590273
[Patent] 哺乳動物のラパマイシン標的蛋白質(mTOP)に結合する性質を持つ新規蛋白質及びその遺伝子2004
- Inventor(s)
  米澤一仁, 原賢太, 吉野健一, 徳永千暮
- Industrial Property Rights Holder
  米澤一仁, 原賢太, 吉野健一, 徳永千暮
- Filing Date
  2004-05-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590273

1. YONEZAWA Kazuyoshi (70283900)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
2. YOSHINO Ken-ichi (90280792)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
3. OSHIRO Noriko (70372662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KIKKAWA Ushio (40150354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 原賢太 (70294254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TOKUNAGA Chiharu 徳永 千春

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"Research of crosstalk between nutrient sensing mTOR signaling pathway and energy metabolic sensing AMPK"Principal Investigator

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[Book] 糖尿病学 20032003

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Data Source

[Book] 糖尿病学20032003

Author(s)

Total Pages

Publisher

Data Source

[Book] 糖尿病学 20032003

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin2006

Author(s)

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NAID

TOKUNAGA Chiharu 徳永千春