Kimura Tomoki 木村朋紀

… Alternative Names

木村朋紀キムラトモキ

KIMURA Tomoki 木村朋紀

Less

Researcher Number	70340859
Other IDs
Affiliation (Current)	2025: 摂南大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2023: 摂南大学, 薬学部, 教授 2018 – 2021: 摂南大学, 理工学部, 准教授 2015: 摂南大学, 理工学部, 准教授 2013 – 2014: 摂南大学, 薬学部, 准教授 2010 – 2012: Setsunan University, 薬学部, 講師 … More 2009: Setsunan University, 摂南大学・薬学部, 講師 2007: 摂南大学, 薬学部, 助教 2003 – 2006: 摂南大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Environmental pharmacy / Basic Section 63030:Chemical substance influence on environment-related / Environmental and hygienic pharmacy Except Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Environmental pharmacy
Keywords	Principal Investigator MTF-1 / 亜鉛 / メタロチオネイン / エピジェネティクス / カドミウム / 毒性発現機序 / 栄養膜幹細胞 / p300 / MTF1 / 遺伝子発現調節 … More / 細胞増殖 / 肝細胞 / ERK / EGF / 亜鉛トランスポーター / NTF-1 / アデノウイルスベクター / 過酸化水素 / 酸化ストレス / アデノウィルスベクター / ドミナントネガティブ体 … More Except Principal Investigator 内分泌かく乱 / エストロゲン作動性 / フルオレン9-ビスフェノール / 評価系 / 感受性 / ヒト由来細胞 / 化学発がん Less

胎盤幹細胞を活用した環境化学物質曝露の影響評価と毒性発現メカニズムの解明Principal Investigator
- Principal Investigator
  
  木村朋紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Setsunan University
Analysis of reproductive toxicity and nonlinear reaction mechanism of bisphenol A analogues in food containers
- Principal Investigator
  
  Nakanishi Tsuyoshi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Gifu Pharmaceutical University
Molecular mechanisms involved in zinc-deficiency mediated epigenetic regulation of gene expressionPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Setsunan University
Molecular mechanisms of zinc-induced epigenetic changes in chromatinof MTF-1 target gene promotersPrincipal Investigator
- Principal Investigator
  
  KIMURA Tomoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Setsunan University
Mechanisms of heavy metal-dependent transactivation by transcription factor MTF-1Principal Investigator
- Principal Investigator
  
  KIMURA Tomoki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Setsunan University
ヒト細胞の化学発がん抵抗性の克服と新規な化学発がんin vitro評価系の開発
- Principal Investigator
  
  伊藤徳夫
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Osaka University
亜鉛応答性転写因子MTF-1による細胞機能調節機構の解析Principal Investigator
- Principal Investigator
  
  木村朋紀
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Setsunan University
転写因子MTF-1を介したストレス防御機構の解析Principal Investigator
- Principal Investigator
  
  木村朋紀
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Setsunan University

[Journal Article] ヒト胎盤幹細胞を用いた環境化学物質影響評価システム開発に向けた毒性発現メカニズムの解明2024
- Author(s)
  小串祥子、木村朋紀
- Journal Title
  
  月刊「細胞」
  
  Volume: 56 Pages: 45-47
- Data Source
  KAKENHI-PROJECT-23K11440
[Journal Article] Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust.2021
- Author(s)
  Jia Y, Zhang H, Hu W, Wang L, Kang Q, Liu J, Nakanishi T, Hiromori Y, Kimura T, Tao S, Hu J.
- Journal Title
  
  J. Hazard. Mater.
  
  Volume: 426 Pages: 127847-127847
- DOI
  10.1016/j.jhazmat.2021.127847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12260, KAKENHI-PROJECT-18H03381
[Journal Article] Cadmium inhibits all-trans-retinoic acid-induced increase of nitroblue tetrazolium reduction activity and induces metallothionein 1G expression in human acute myelocytic leukemia HL-60 Cells2020
- Author(s)
  Shoko Ogushi, Shuji Ikemoto, Nobuhiko Miura, Tsuyoshi Nakanishi, Tomoki Kimura
- Journal Title
  
  BPB Reports
  
  Volume: 3 Pages: 34-38
- NAID
  130007944907
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03381
[Journal Article] CpG site-specific regulation of metallothionein-1 gene expression2020
- Author(s)
  Shoko Ogushi, Yuya Yoshida, Tsuyoshi Nakanishi, Tomoki Kimura
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 17 Pages: 5946-5946
- DOI
  10.3390/ijms21175946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03381
[Journal Article] In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice.2020
- Author(s)
  Yoshida I, Ishida K, Yoshikawa H, Kitamura S, Hiromori Y, Nishioka Y, Ido A, Kimura T, Nishikawa JI, Hu J, Nagase H, Nakanishi T.
- Journal Title
  
  J Hazard Mater.
  
  Volume: 385 Pages: 121526-121526
- DOI
  10.1016/j.jhazmat.2019.121526
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06737, KAKENHI-PROJECT-19K19413, KAKENHI-PROJECT-18J01790, KAKENHI-PROJECT-18H03381
[Journal Article] Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8 γ2020
- Author(s)
  Yamamoto Katsuya、Hiromori Youhei、Matsumaru Daisuke、Ishii Yoichiro、Takeshita Yuki、Tsubakihara Iori、Kimura Tomoki、Nagase Hisamitsu、Nakanishi Tsuyoshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 9 Pages: 581-587
- DOI
  10.2131/jts.45.581
- NAID
  130007895029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07361, KAKENHI-PROJECT-18K06737, KAKENHI-PROJECT-18H03381
[Journal Article] Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells2019
- Author(s)
  Tomoki Kimura, Takuomi Hosaka, Tsuyoshi Nakanishi, Osamu Aozasa
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 4 Pages: 309-316
- DOI
  10.2131/jts.44.309
- NAID
  130007623314
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03381
[Journal Article] Screening of House Dust from Chinese Homes for Chemicals with Liver X Receptors Binding Activities and Characterization of Atherosclerotic Activity Using an in Vitro Macrophage Cell Line and ApoE-/- Mice.2019
- Author(s)
  Hu W, Jia Y, Kang Q, Peng H, Ma H, Zhang S, Hiromori Y, Kimura T, Nakanishi T, Zheng L, Qiu Y, Zhang Z, Wan Y, Hu J.
- Journal Title
  
  Environ Health Perspect
  
  Volume: 127 Issue: 11 Pages: 117003-117003
- DOI
  10.1289/ehp5039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06737, KAKENHI-PROJECT-18H03381
[Journal Article] The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective2016
- Author(s)
  Kimura T, Kambe T
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 17 Issue: 3 Pages: 1-22
- DOI
  10.3390/ijms17030336
- NAID
  120005947123
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04501, KAKENHI-PROJECT-25460179, KAKENHI-PROJECT-26660086
[Journal Article] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter2011
- Author(s)
  奥村文香、Yong Li、伊藤徳夫、中西剛、磯部正和、Glen K.Andrews, 木村朋紀
- Journal Title
  
  Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 1809巻
  
  Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p3002011
- Author(s)
  木村朋紀、奥村文香、小野寺章、中西剛、伊藤徳夫、磯部正和
- Journal Title
  
  The Journal of Toxicological Sciences 36巻
- NAID
  10028101162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p3002011
- Author(s)
  木村朋紀
- Journal Title
  
  Journal of Toxicological Sciences
  
  Volume: 36(印刷中)
- NAID
  10028101162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Molecular mechanisms of zinc-mediated induction and chromium(VI)-mediated inhibition of mouse metallothionein-I gene transcription2010
- Author(s)
  木村朋紀
- Journal Title
  
  Journal of Health Science 56巻(印刷中)
  
  Pages: 1-6
- NAID
  130000254713
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Molecular mechanisms of zinc-mediated induction and chromium(VI)-mediated inhibition of mouse metallothionein-I gene transcription2010
- Author(s)
  木村朋紀
- Journal Title
  
  Journal of Health Science 56巻
  
  Pages: 161-166
- NAID
  130000254713
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Mechanisms of heavy metal sensing by metal response element-binding transcription factor-12009
- Author(s)
  木村朋紀
- Journal Title
  
  Journal of Health Science 55巻
  
  Pages: 484-494
- NAID
  130000127927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Mechanisms of heavy metal sensing by metal response element-binding transcription factor-12009
- Author(s)
  木村朋紀、伊藤徳夫、Glen K.Andrews
- Journal Title
  
  Journal of Health Science 55巻
  
  Pages: 484-494
- NAID
  130000127927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790137
[Journal Article] Metal response element-binding transcription factor-1 is activated by degradation of metallothionein.2009
- Author(s)
  Kimura, T., Okumura, F., Oguro, I., Nakanishi, T., Sone, T., Isobe, M., Tanaka, K., Itoh, N.
- Journal Title
  
  J. Health Sci. 55
  
  Pages: 72-76
- NAID
  110007055930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659029
[Journal Article] Chromium(VI)inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-P300 complex.2008
- Author(s)
  Kimura, T., Li, Y., Okumura, R, Itoh, N., Nakanishi, T., Sone, T., Isobe, M., Andrews, GK.
- Journal Title
  
  Biochem. J. 415
  
  Pages: 477-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659029
[Journal Article] Function of metallothionein in gene expression and signal transduction-Newly found protective role of metallothionein2008
- Author(s)
  Tomoki Kimura, Norio Itoh
- Journal Title
  
  J. Health Sci. 54(印刷中)
- NAID
  110006684371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659029
[Journal Article] Role of Metal-Responsive Transcription Factor-1 (MTF-1) in EGF-Dependent DNA Synthesis in Primary Hepatocytes2006
- Author(s)
  Tomoki Kimura, et al.
- Journal Title
  
  Journal of Cellular Biochemistry 99
  
  Pages: 485-494
- Data Source
  KAKENHI-PROJECT-17790104
[Journal Article] C-terminal deletion mutant of MRE-binding transcription factor-1 inhibits MRE-driven gene expression2004
- Author(s)
  Tomoki Kimura, et al.
- Journal Title
  
  Journal of Cellular Biochemistry 93・3
  
  Pages: 609-618
- Data Source
  KAKENHI-PROJECT-15790080
[Presentation] ビスフェノールA曝露による絨毛外性栄養膜細胞機能への影響評価2024
- Author(s)
  小串祥子、阿部令菜、中西剛、中嶋義隆、中村武浩、木村朋紀
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K11440
[Presentation] ヒト胎盤由来栄養膜幹細胞や絨毛外性栄養膜細胞株を利用したカドミウムの胎盤毒性評価2023
- Author(s)
  木村朋紀
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K11440
[Presentation] 絨毛外性栄養膜細胞HTR-8/SVneoの遊走へのビスフェノールAの影響2023
- Author(s)
  阿部令菜、小串祥子、中村武浩、中嶋義隆、木村朋紀
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-23K11440
[Presentation] リンパ肉腫細胞P1798におけるカドミウム長期曝露によるメタロチオネイン誘導能の変化とその役割2016
- Author(s)
  木村　朋紀、川嶋　真実、青笹　治
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  愛知県産業労働センター（名古屋）
- Year and Date
  2016-07-01
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] 金属曝露がもたらすエピジェネティックな変化とその分子機構2016
- Author(s)
  木村　朋紀
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] メタロチオネイン遺伝子発現に対するエピジェネティックな制御機構の解析2015
- Author(s)
  木村　朋紀
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  ホテル日航金沢（金沢）
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] 金属曝露がもたらすエピジェネティックな変化とその分子機構2014
- Author(s)
  木村　朋紀
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県つくば市竹園）
- Year and Date
  2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] 重金属応答性転写因子MTF-1の標的遺伝子における亜鉛によるクロマチン構造変化2013
- Author(s)
  保坂卓臣、藤森廣幸、木村朋紀
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン-I遺伝子プロモーター領域のクロマチン構造と転写活性2012
- Author(s)
  田中亨、古田雄三、保坂卓臣、木村朋紀、藤森廣幸、磯部正和
- Organizer
  フォーラム2012：衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] Transcriptional activation enhanced by the change in chromatin structure of mouse metallothionein-I promoter2012
- Author(s)
  保坂卓臣、木村朋紀、古田雄三、藤森廣幸、磯部正和
- Organizer
  第6回アジア毒性学会学術集会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン-I遺伝子の転写におけるクロマチンリモデリングファクターSnf2Hの役割2012
- Author(s)
  射手園雄一、保坂卓臣、岡田和也、木村朋紀、藤森廣幸、磯部正和
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] クロマチンリモデリングファクターBrm・Brg1欠損細胞におけるメタロチオネイン遺伝子発現2012
- Author(s)
  岡田和也、保坂卓臣、射手園雄一、木村朋紀、藤森廣幸、磯部正和
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter and the epigenetic changes brings enhanced transcriptional activation2012
- Author(s)
  木村朋紀、古田雄三、奥村文香、保坂卓臣、磯部正和、Glen K. Andrews
- Organizer
  The International Society of Zinc Biology Conference
- Place of Presentation
  メルボルン、オーストラリア
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン-I遺伝子の転写におけるクロマチンリモデリングファクターSnf2Hの役割2012
- Author(s)
  射手園雄一、保坂卓臣、岡田和也、木村朋紀、藤森廣幸、磯部正和
- Organizer
  フォーラム2012：衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] 重金属によるメタロチオネイン遺伝子の転写制御2012
- Author(s)
  木村朋紀
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] 亜鉛によるメタロチオネイン遺伝子発現におけるクロマチン構造変化とその意義2012
- Author(s)
  保坂卓臣、木村朋紀、古田雄三、藤森廣幸、磯部正和
- Organizer
  第39回日本毒性学会学術年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン-I遺伝子プロモーター領域のクロマチン構造と転写活性2012
- Author(s)
  田中亨、古田雄三、保坂卓臣、木村朋紀、藤森廣幸、磯部正和
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] マウスメタロチオネイン-I遺伝子プロモーター領域におけるクロマチン構造変化と転写量との関連性2012
- Author(s)
  保坂卓臣、木村朋紀、古田雄三、藤森廣幸、磯部正和
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter2011
- Author(s)
  木村朋紀、奥村文香、Yong Li、伊藤徳夫、中西剛、磯部正和、Glen K. Andrews
- Organizer
  2011 International Conference Metals andGenetics
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter2011
- Author(s)
  木村朋紀、奥村文香、Yong Li、伊藤徳夫、中西剛、磯部正和、Glen K. Andrews
- Organizer
  2011 International Conference Metals and Genetics
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン遺伝子発現に関わるクロマチンリモデリングファクター2011
- Author(s)
  保坂卓臣、木村朋紀、射手園雄一、岡田和也、藤森廣幸、磯部正和
- Organizer
  フォーラム2011衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン遺伝子発現に関わるクロマチンリモデリングファクター2011
- Author(s)
  保坂卓臣、木村朋紀、射手園雄一、岡田和也、藤森廣幸、磯部正和
- Organizer
  フォーラム2011 衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] メタロチオネイン遺伝子の転写に伴うクロマチン構造変化とその意義2011
- Author(s)
  木村朋紀、奥村文香、古田雄三、保坂卓臣、藤森廣幸、磯部正和
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会2011
- Place of Presentation
  名古屋
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-23790163
[Presentation] Cr(VI) inhibits mouse metallothionein-I gene transcription by modifying transactivation potential of the co-activator p3002010
- Author(s)
  木村朋紀
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島文理大学(徳島)
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 6価クロムによるメタロチオネイン遺伝子発現抑制機構の解析2010
- Author(s)
  木村朋紀
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター(沖縄)
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 重金属応答性転写因子MTF-1によるメタロチオネイン誘導における細胞内シグナル伝達系の役割2010
- Author(s)
  奥村文香、木村朋紀、磯部正和
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ、岡山
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 亜鉛によるメタロチオネイン遺伝子発現に伴うクロマチン構造変化に関与する因子群の解析2010
- Author(s)
  木村朋紀
- Organizer
  フォーラム2010:衛生薬学・環境トキシコロジー
- Place of Presentation
  星薬科大学(東京)
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter.2010
- Author(s)
  木村朋紀、奥村文香、Yong Li、伊藤徳夫、中西剛、磯部正和、Glen K.Andrews
- Organizer
  第60回藤原セミナー
- Place of Presentation
  大阪国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 6価クロムによるメタロチオネイン遺伝子発現抑制機構の解析2010
- Author(s)
  木村朋紀、奥村文香、小野寺章、中西剛、伊藤徳夫、磯部正和
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター、沖縄
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 亜鉛によるメタロチオネイン遺伝子発現に伴うクロマチン構造変化に関与する因子群の解析2010
- Author(s)
  木村朋紀、古田雄三、奥村文香、磯部正和
- Organizer
  フォーラム2010:衛生薬学・環境トキシコロジー
- Place of Presentation
  星薬科大学、東京
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Cr(VI) inhibits mouse metallothionein-I gene transcription by modifying transactivation potential of the co-activator p3002010
- Author(s)
  木村朋紀、奥村文香、小野寺章、中西剛、伊藤徳夫、磯部正和
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島文理大、徳島
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 細胞内シグナル伝達系を介した重金属応答性転写因子MTF-1によるメタロチオネイン誘導2010
- Author(s)
  木村朋紀
- Organizer
  日本薬学会第130年会
- Place of Presentation
  桃太郎アリーナ(岡山)
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter.2010
- Author(s)
  木村朋紀
- Organizer
  第60回藤原セミナー
- Place of Presentation
  大阪国際会議場(大阪)
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] メタロチオネイン遺伝子の転写に伴うクロマチン内ヒストンH3減少の機序解析2010
- Author(s)
  古田雄三、木村朋紀、奥村文香、磯部正和
- Organizer
  第2回メタロミクス研究フォーラム
- Place of Presentation
  京都薬科大、京都
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying transactivation potential of the co-activator p3002010
- Author(s)
  木村朋紀、奥村文香、小野寺章、中西剛、伊藤徳夫、磯部正和
- Organizer
  The XII International Congress of Toxicology
- Place of Presentation
  バルセロナ、スペイン
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Chromium(VI) inhibits mouse metallothionein-I gene transcription by modifying transactivation potential of the co-activator p3002010
- Author(s)
  木村朋紀
- Organizer
  The XII International Congress of Toxicology
- Place of Presentation
  バルセロナ(スペイン)
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 転写因子MTF-1を介したマウスメタロチオネイン-I遺伝子発現にともなうクロマチン構造変化2009
- Author(s)
  木村朋紀、奥村文香、Yong Li、伊藤徳夫、中西剛、曽根知道、磯部正和、Glen K.Andrews
- Organizer
  第3回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター、東京
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] カドミウムによるメタロチオネイン誘導におけるリン酸化シグナル伝達系の役割2009
- Author(s)
  木村朋紀、奥村文香、磯部正和
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会2009
- Place of Presentation
  東京大学、東京
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 転写因子MTF-1を介したマウスメタロチオネイン-I遺伝子発現にともなうクロマチン構造変化2009
- Author(s)
  木村朋紀
- Organizer
  第3回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター(東京)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 転写因子MTF-1を介した遺伝子発現にともなうクロマチン構造変化とその持続性2009
- Author(s)
  奥村文香、木村朋紀、Yong Li、伊藤徳夫、中西剛、磯部正和、Glen K.Andrews
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄コンベンションセンター、沖縄
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] カドミウムによるメタロチオネイン誘導におけるリン酸化シグナル伝達系の役割2009
- Author(s)
  木村朋紀
- Organizer
  メタロチオネインおよびメタルバイオサイエンス研究会2009
- Place of Presentation
  東京大学山上会館(東京)
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Chromium(VI)inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex2009
- Author(s)
  木村朋紀
- Organizer
  The 5th International Congress of Asian Society of Toxicology
- Place of Presentation
  Taipei Veterans General Hospital(台湾)
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] カドミウムによるメタロチオネイン誘導におけるJNKの役割2009
- Author(s)
  奥村文香、木村朋紀、磯部正和
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  岩手県民情報交流センター、盛岡
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 重金属応答性転写因子MTF-1による転写活性化機構に関する研究2009
- Author(s)
  木村朋紀
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄コンベンションセンター、沖縄
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Zinc-induced epigenetic changes in the mouse metallothionein-I promoter chromatin are mediated by the zinc-sensing transcription factor MTF-12009
- Author(s)
  奥村文香、木村朋紀、Yong Li Y、伊藤徳夫、中西剛、曽根知道、磯部正和、Glen K.Andrews
- Organizer
  The 5th International Congress of Asian Society of Toxicology
- Place of Presentation
  台北、台湾
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Chromium (VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1.p300 complex2009
- Author(s)
  木村朋紀
- Organizer
  The 5th International Congress of Asian Society of Toxicology
- Place of Presentation
  台北、台湾
- Year and Date
  2009-09-13
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] 重金属応答性転写因子MTF-1による転写活性化機構に関する研究2009
- Author(s)
  木村朋紀
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄コンベンションセンター(沖縄)
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21790137
[Presentation] Mechanisms of metallothionein gene transcription and epigenetic changes in the promoter
- Author(s)
  木村朋紀
- Organizer
  X ISTERH2013
- Place of Presentation
  京王プラザホテル（東京都新宿区西新宿）
- Invited
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] リンパ肉腫細胞P1798へのカドミウム長期処理によるメタロチオネイン誘導能の変化
- Author(s)
  福本　冬里、木村　良宇、保坂　卓臣、木村　朋紀
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば国際会議場（茨城県つくば市竹園）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] 重金属応答性転写因子MTF-1による転写活性化に対する転写共役因子p300の促進効果
- Author(s)
  保坂卓臣、友近祐真、竹村知、下村希実、木村朋紀
- Organizer
  フォーラム2013：衛生薬学・環境トキシコロジー
- Place of Presentation
  九州大学医学部百年講堂（福岡市東区）
- Data Source
  KAKENHI-PROJECT-25460179
[Presentation] 重金属応答性転写因子MTF-1の亜鉛依存的な DNA結合における転写共役因子p300の役割
- Author(s)
  友近祐真、北澤文子、竹村知、下村希実、保坂卓臣、木村朋紀
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館（熊本市中央区）
- Data Source
  KAKENHI-PROJECT-25460179

1. Nakanishi Tsuyoshi (50303988)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. HOSAKA Takuomi (30611579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 伊藤徳夫 (60176352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 永瀬容康 (00252700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 永瀬久光 (40141395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 井戸章子 (00336629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. HIROMORI Youhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. 神戸大朋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 松丸大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kimura Tomoki 木村 朋紀

木村 朋紀 キムラ トモキ

KIMURA Tomoki 木村 朋紀

Research Projects

Research Products

Co-Researchers

胎盤幹細胞を活用した環境化学物質曝露の影響評価と毒性発現メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of reproductive toxicity and nonlinear reaction mechanism of bisphenol A analogues in food containers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms involved in zinc-deficiency mediated epigenetic regulation of gene expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of zinc-induced epigenetic changes in chromatinof MTF-1 target gene promotersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of heavy metal-dependent transactivation by transcription factor MTF-1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト細胞の化学発がん抵抗性の克服と新規な化学発がんin vitro評価系の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

亜鉛応答性転写因子MTF-1による細胞機能調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

転写因子MTF-1を介したストレス防御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ヒト胎盤幹細胞を用いた環境化学物質影響評価システム開発に向けた毒性発現メカニズムの解明2024

Author(s)

Journal Title

Data Source

[Journal Article] Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cadmium inhibits all-trans-retinoic acid-induced increase of nitroblue tetrazolium reduction activity and induces metallothionein 1G expression in human acute myelocytic leukemia HL-60 Cells2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] CpG site-specific regulation of metallothionein-1 gene expression2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8 γ2020

Author(s)

Kimura Tomoki 木村朋紀

木村朋紀キムラトモキ

KIMURA Tomoki 木村朋紀