HASHIMOTO Ken 橋本研

Researcher Number	70343457
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2010: 明海大学, 歯学部, 助教 2009: 明海大学, 歯学部, 助教授 2004 – 2006: 明海大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Functional basic dentistry Except Principal Investigator Conservative dentistry / Functional basic dentistry
Keywords	Principal Investigator 歯周病 / マクロファージ / アスパラギン合成酵素 Except Principal Investigator 創傷治癒 / メカニズム / 修復象牙質 / Enamel Proteins / プレニルアルコール / ビタミンK_2 / ベンズアルデヒド誘導体 … More / 細胞のタイプ / 環状α,β-不飽和ケトン / 細胞間での感受性の差 / β不飽和ケトン / 環状α / 構造活性相関 / オートファジー / アポトーシス / 細胞死のタイプ / 口腔扁平上皮癌細胞 Less

A study of the mechanism of reparative dentin by Enamel Proteins.
- Principal Investigator
  
  YUKIO Nakamura
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
Basic research for the development of autophagy-inducing therapy against human oral squamous cell carcinoma cell lines
- Principal Investigator
  
  SAKAGAMI Hiroshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University
歯周病によるマクロファージの活性化とアスパラギン合成酵素誘導Principal Investigator
- Principal Investigator
  
  橋本研
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Meikai University

All 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Steroidal glycosides from Furcraea foetida and their cytotoxic activity.2009
- Author(s)
  Yokosuka A, Sano T, Hashimoto K, Sakagami H, Mimaki Y
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 1161-1166
- NAID
  130000124800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity.2009
- Author(s)
  Yokosuka A, Sano T, Hashimoto K, Sakagami H, Mimaki Y
- Journal Title
  
  Chem Pharm Bull 57
  
  Pages: 1425-1430
- NAID
  130000124549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Type of cell death induced byα-trifluoromethyl acyloins in oral squamous cell carcinoma.2009
- Author(s)
  Ideo A, Hashimoto K, Shimada J, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 175-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtha[2, 3-b]furan-4, 9-diones and related compounds in human tumor cell lines: relationship to electronic structure.2009
- Author(s)
  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohiashi N, Sakagami H, Yamamoto K, Tanaka A
- Journal Title
  
  Anticancer Res 29
  
  Pages: 455-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1, 4]oxazine and 2-aminotropone derivatives.2009
- Author(s)
  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 1123-1130
- NAID
  120005520592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell line2009
- Author(s)
  Hatano H, Takekawa H, Hashimoto K, Ishihara M, et al., (8名)
- Journal Title
  
  Anticancer Research 29
  
  Pages: 3079-3086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines2009
- Author(s)
  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.
- Journal Title
  
  relationship to electronic structure. Anticancer Res. Jan 29(1)
  
  Pages: 455-464
- Data Source
  KAKENHI-PROJECT-20592233
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines : relationship to electronic structure2009
- Author(s)
  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, 他4名
- Journal Title
  
  Anticancer Res. 29(1)
  
  Pages: 455-464
- NAID
  120005520593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592233
[Journal Article] Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines2009
- Author(s)
  Hatano H, Takekawa H, Hashimoto K, Ishihara M, Kawase M, Chu Q, Wang QT, Sakagami H
- Journal Title
  
  Anticancer Res 29
  
  Pages: 3079-3086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008
- Author(s)
  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1069-1078
- NAID
  120005520596
- Data Source
  KAKENHI-PROJECT-20592233
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by β-cyclodextrin benzaldehyde inclusion compound.2008
- Author(s)
  Liu Y, Sakagami H, Hashimoto K, Kikuchi H, Amano O, Ishihara M, Kanda Y, Kunii S, Kochi M, Zhang W, Yu G
- Journal Title
  
  Anticancer Res 28
  
  Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificic cytotoxicity and type of cell death induced by sodium 5, 6-benzylidene-L-ascorbate.2008
- Author(s)
  Kishino K, Hashimoto K, Amano O, Kochi M, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 2577-2584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols.2008
- Author(s)
  Sakagami H, Hashimoto K, Suzuki F, Ishihara M, Kikuchi H, Katayama T, Satoh K
- Journal Title
  
  Anticancer Res 28
  
  Pages: 151-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008
- Author(s)
  Murayama H, Miyahara K, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, 他4人
- Journal Title
  
  Anticancer Res. 28
  
  Pages: 1069-1078
- NAID
  120005520596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592233
[Journal Article] Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line2008
- Author(s)
  Hashimoto K, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1713-1718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008
- Author(s)
  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1069-1078
- NAID
  120005520596
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line.2008
- Author(s)
  Hashimoto K, Sakagami H
- Journal Title
  
  Anticancer Res 28
  
  Pages: 1713-1718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specific cytotoxic activity and type of cell death induced by 4-trifluoromethylimidazoles in human oral squamous cell carcinoma cell lines.2007
- Author(s)
  Takekawa F, Nagumo T, Shintani S, Hashimoto K, Kikuchi H, Katayama T, Ishihara M, Amano O, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4065-4070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Journal Article] Tumor-specificity and type of cell death induced by phenoxazines.2007
- Author(s)
  Suzuki F, Hashimoto K, Ishihara M, Westman G, Samuelsson K, Kawase M, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 27
  
  Pages: 4233-4238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] タンニンータンパク質複合体のヒト癌細胞株に対する腫瘍選択性と誘導される細胞死のタイプ2010
- Author(s)
  坂上宏, 岸野香織, 橋本研, 野崎阿季子, 波多野力
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] ヒト口腔癌細胞の細胞死誘導におけるDNaseγの役割2009
- Author(s)
  橋本研, 坂上宏
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] ベンズアルデヒドによりヒト口腔扁平上皮癌細胞に誘導される細胞死の解析2009
- Author(s)
  岸野香織, 橋本研, 天野修, 坂上宏
- Organizer
  第51回歯科基礎医学会
- Place of Presentation
  新潟
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] Induction of non-apoptosis by a, b-unsaturated ketones in OSCC cell lines2008
- Author(s)
  Sakagami H, Hashimoto K, Ishihara M, Nagasaka H, Kawase M, Dimmock J
- Organizer
  IADR
- Place of Presentation
  Toronto
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] 複素環式化合物の腫瘍選択性と誘導される細胞死のタイプ2008
- Author(s)
  坂上宏, 橋本研, 小林正樹, 鈴木史香, 竹川文弘石原真理子, 天野修, 菊地寛高, 中村幸生, 河瀬雅美, 本橋登
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19592156
[Presentation] ベンズアルデヒド類のヒト口腔扁平上皮癌細胞に対する選択毒性2007
- Author(s)
  坂上宏, 劉宇, 岸野香織, 小林正樹, 橋本研, 石原真理子
- Organizer
  第49回歯科基礎医学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19592156

1. SAKAGAMI Hiroshi (50138484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
2. KAWASE Masami (20112641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. MIMAKI Yoshihiro (90229790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. YUKIO Nakamura (40207931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 須田朋代 (60226579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HASHIMOTO Ken 橋本 研

Research Projects

Research Products

Co-Researchers

A study of the mechanism of reparative dentin by Enamel Proteins.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic research for the development of autophagy-inducing therapy against human oral squamous cell carcinoma cell lines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

歯周病によるマクロファージの活性化とアスパラギン合成酵素誘導Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Steroidal glycosides from Furcraea foetida and their cytotoxic activity.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Triterpene glycosides from the whole plant of Anemone hupehensis var. japonica and their cytotoxic activity.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Type of cell death induced byα-trifluoromethyl acyloins in oral squamous cell carcinoma.2009

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtha[2, 3-b]furan-4, 9-diones and related compounds in human tumor cell lines: relationship to electronic structure.2009

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1, 4]oxazine and 2-aminotropone derivatives.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell line2009

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines2009

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines : relationship to electronic structure2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Tumor-specific cytotoxic activity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines2009

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by β-cyclodextrin benzaldehyde inclusion compound.2008

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specificic cytotoxicity and type of cell death induced by sodium 5, 6-benzylidene-L-ascorbate.2008

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specificity and type of cell death induced by vitamin K2 derivatives and prenylalcohols.2008

Author(s)

Journal Title

Data Source

[Journal Article] Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.2008

HASHIMOTO Ken 橋本研