Kojima Hirotatsu 小島宏建

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KOJIMA Hirotatsu 小島宏建

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Researcher Number	70345255
Other IDs
Affiliation (Current)	2025: 東京大学, 創薬機構, 特任教授
Affiliation (based on the past Project Information) *help	2007 – 2009: The University of Tokyo, 生物機能制御化合物ライブラリー機構, 准教授 2007: The University of Tokyo, Associate Professor 2005 – 2006: 東京大学, 大学院薬学系研究科, 助手 2003 – 2005: 東京大学, 大学院・薬学系研究科, 助手
Review Section/Research Field	Principal Investigator Drug development chemistry / Biological Sciences Except Principal Investigator Biophysics
Keywords	Principal Investigator 蛍光 / 診断 / 可視化 / 有機化学 / 薬学 / 分析科学 / 生体分子 / 分子認識 / 近赤外 / イメージング … More / 画像化 / in vivo / 一酸化窒素 / トリアゾール / ジアミン / シアニン … More Except Principal Investigator MRI / Photoinduced electron Transfer / Near Infra-red Emission / Fluorescent Probe / Molecular Imaging / DAC / 蛍光顕微鏡 / 一酸化窒素 / 超寿命蛍光 / 長寿命蛍光 / 可視化 / バイオイメージング / 亜鉛 / レシオ / 蛍光 / 光誘起電子移動 / 近赤外発光 / 蛍光プローブ / 分子イメージング Less

Development of diagnostic imaging reagents based on designing and synthesizing fluorescent probesPrincipal Investigator
- Principal Investigator
  
  KOJIMA Hirotatsu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
近赤外蛍光を利用し、生体分子を選択的に促える新規光診断法の開発Principal Investigator
- Principal Investigator
  
  小島宏建
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
近赤外蛍光を利用するバイオイメージングプローブの創製と体内診断薬への展開Principal Investigator
- Principal Investigator
  
  小島宏建
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of Bioimaging Probes For In Vivo Application
- Principal Investigator
  
  NAGANO Tetsuo
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
In vivo検出可能な近赤外一酸化窒素感受性蛍光色素の開発研究Principal Investigator
- Principal Investigator
  
  小島宏建
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo

All 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book Patent

[Book] マクマリー生化学反応機構-ケミカルバイオロジーの理解のために-2007
- Author(s)
  長野哲雄監訳、浦野泰照、小島宏建、鈴木紀行、平野智也訳
- Total Pages
  20
- Publisher
  東京化学同人
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.2010
- Author(s)
  Oushiki, D., Kojima, H., Terai, T., Arita, M., Hanaoka, K., Urano, Y., Nagano, T.
- Journal Title
  
  J. Am. Chem. Soc. 132
  
  Pages: 2795-2801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689003
[Journal Article] Molecular design strategies for near-infrared ratiometric fluorescent probes based on unique spectral properties of aminocyanines.2009
- Author(s)
  Kiyose, K., Aizawa, S., Sasaki, E., Kojima, H., Hanaoka, K., Terai, T., Urano, Y., Nagano, T.
- Journal Title
  
  Chem. Eur. J. 15
  
  Pages: 9191-9200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689003
[Journal Article] 生体イメージングを目指した近赤外蛍光プローブの開発研究2008
- Author(s)
  小島宏建
- Journal Title
  
  薬誌 128
  
  Pages: 1653-1663
- NAID
  110006991380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689003
[Journal Article] Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase (GST) and application for activity imaging in living cells.2008
- Author(s)
  Fujikawa, Y., Urano, Y., Komatsu, T., Hanaoka, K., Kojima, H., Terai, T., Inoue, H., Nagano, T.
- Journal Title
  
  J. Am. Chem. Soc. 130
  
  Pages: 14533-14543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689003
[Journal Article] Functional Near-Infrared Fluorescent Probes.2008
- Author(s)
  Kiyose, K., Kojima, H., and Nagano, T.
- Journal Title
  
  Chemistry-An Asian Journal 3
  
  Pages: 506-515
- Data Source
  KAKENHI-PROJECT-17689006
[Journal Article] Functional Near-Infrared Fluorescent Probes2008
- Author(s)
  Kazuki Kiyose, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  Chemistry-An Asian journal 3
  
  Pages: 506-515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Functional Near-Infrared Fluorescent Probes2008
- Author(s)
  Kiyose, K., Kojima, H., Nagano, T.
- Journal Title
  
  Chemistry-An Asian Journal 3
  
  Pages: 506-515
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer:Key Role of Ortho Substituion2007
- Author(s)
  Matsumoto, T., Urano, Y., Shoda, T., Kojima, H., Nagano, T.
- Journal Title
  
  Organic Letters 9
  
  Pages: 3375-3377
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Highly Activatable and Rapidly Releasable Caged Fluorescein Derivatives2007
- Author(s)
  Tomonori Kobayashi, Yasuteru Urano, Mako Kamiya, Tasuku Ueno, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J Am. Chem. Soc. 129
  
  Pages: 6696-6697
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] "Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron Transfer-Controlled Fluorescence ON/OFF Switching2007
- Author(s)
  Hisato Sunahara, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am Chem. Soc. 129
  
  Pages: 5597-5604
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Design and Synthesis of Fluorescent Probes for Selective Detection of Highly Reactive Oxygen Species in Mitochondria of Living Cells2007
- Author(s)
  Yuichiro Koide, Yasuteru Urano, Suguru Kenmoku, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 10324-10325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer : Key Role of Ortho Substituion2007
- Author(s)
  Takuya Matsumoto, Yasuteru Urano, Takuji Shoda, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  Org. Lett. 9
  
  Pages: 3375-3377
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Design and Synthesis of a Library of BODIPY-Based Environmental Polarity Sensors Utilizing Photoinduced Electron Transfer-Controlled Fluorescence ON/OFF Switching2007
- Author(s)
  Sunahara, H., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 129
  
  Pages: 5597-5604
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Highly Specific, Rhodamine-Based Fluorescence Probe for Hypochlorous Acid and Its Application to Real-Time Imaging of Phagocytosis2007
- Author(s)
  Suguru Kenmoku, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 7313-7318
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc2007
- Author(s)
  Kensuke Komatsu, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 129
  
  Pages: 13447-13454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Design and Synthesis of Fluorescent Probes for Selective Detection of Highly Reactive Oxygen Species in Mitochondria of Living Cells2007
- Author(s)
  Koide, Y., Urano, Y., Kenmoku, S., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 129
  
  Pages: 10324-10325
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of an Iminoooumarin-Based Zinc Sensor Suitable for Ratio metric Fluorescence Imaging of Neuronal Zinc2007
- Author(s)
  Komatsu, K., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 129
  
  Pages: 13447-13454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc2007
- Author(s)
  Komatsu, K., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 129
  
  Pages: 13447-13454
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Highly Specific, Rhodamine-Based Fluorescence Probefor Hypoehlorous Acid and Its Application to Real-Time Imaging of Phagocytosis2007
- Author(s)
  Kenmoku, S., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society. 129
  
  Pages: 7313-7318
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Highly Activatable and Rapidly Releasable Caged Fluorescein Derivatives2007
- Author(s)
  Kobayashi, T., Urano, Y., Kamiya, M., Ueno, T., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 129
  
  Pages: 6696-6697
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Tunable Design Strategy for Fluorescence Probes Based on 4-Substituted BODIPY Chromophore; Improvement of Highly Sensitive Fluorescence Probe for Nitric Oxide2006
- Author(s)
  Yu Gabe, Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  Analytical and bioanalytical Chemistry 386
  
  Pages: 621-626
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Mechanism-Based Molecular Design of Highly Selective Fluorescence Probes for Nitrative Stress2006
- Author(s)
  Ueno, T., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 128
  
  Pages: 10640-10641
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore2006
- Author(s)
  Kazuki Kiyose, Hirotatsu Kojima, Yasuteru Urano, Tetsuo Nagano
- Journal Title
  
  J. Am Chem. Soc. 128
  
  Pages: 6548-6549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Mechanism-Based Molecular Design of-Highly Selective Fluorescence Probes for Nitrative Stress2006
- Author(s)
  Tasuku Ueno, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am Chem. Soc. 128
  
  Pages: 10640-10641
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Tunable Design Strategy for Fluorescence Probes Based on 4-Substituted BODIPY Chromophore;Improvement of Highly Sensitive Fluorescence Probe for Nitric Oxide2006
- Author(s)
  Gabe, Y., Ueno, T., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Analytical and Bioanalytical Chemistry 386
  
  Pages: 621-626
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore2006
- Author(s)
  Kiyose, K., Kojima, H., Urano, Y., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 128
  
  Pages: 6548-6549
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a ratiometric fluorescent zinc ion probe in near-infrared region, based on tricarbocyanine chromophore.2006
- Author(s)
  Kiyose, K., Kojima, H., Urano, Y., Nagano, T.
- Journal Title
  
  J.Am.Chem.Soc. 128
  
  Pages: 6548-6549
- Data Source
  KAKENHI-PROJECT-17689006
[Journal Article] Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs2005
- Author(s)
  Eita Sasaki, Hirotatsu Kojima, Hiroaki Nishimatsu, Yasuteru Urano, Kazuya Kikuchi, Yasunobu Hirata, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 127
  
  Pages: 3684-3685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications2005
- Author(s)
  Eri Kawabata, Kazuya Kikuchi, Yasuteru Urano,. Hirotatsu Kojima, Akira Odani, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 127
  
  Pages: 818-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Selective Zinc Sensor Molecules with Various Affinities for Zn^<2+>, Revealing Dynamics and Regional Distribution of Synaptically Released Zn^<2+>in Hippocampal Slices2005
- Author(s)
  Kensuke Komatsu, Kazuya Kikuchi, Hirotatsu Kojima, Yasuteru Urano, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 127
  
  Pages: 10197-10204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Design and Synthesis of Zinc-Selective Chelators for Extracellular Applications2005
- Author(s)
  Kawabata, E., Kikuchi, K., Urano, Y., Kojima, H., Odani, A., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 127
  
  Pages: 818-819
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs.2005
- Author(s)
  Eita Sasaki, Hirotatsu Kojimaら
- Journal Title
  
  J.Am.Chem.Soc. 127・11
  
  Pages: 3684-3685
- Data Source
  KAKENHI-PROJECT-15790070
[Journal Article] Highly Sensitive Near-infrared Fluorescence Probes for Nitric Oxide and Their Application to Isolated Organs2005
- Author(s)
  Sasaki, E., Kojima, H., Nishimatsu, H., Urano, Y., Kikuchi, K.., Hirata Y., Nagano. T.
- Journal Title
  
  Journal of the American Chemical Society 127
  
  Pages: 3684-3685
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Selective Zinc Sensor Molecules with Various Affinities for Zn^<2+>, Revealing Dynamics and Regional Distribution of Synaptically Released Zn^<2+> in Hippocampal Slices2005
- Author(s)
  Komatsu, K., Kikuchi, K., Kojima, H., Urano Y., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 127
  
  Pages: 10197-10204
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Rational Design of Novel Photoinduced Electron Transfer Type Fluorescent Probes for Sodium Cation2004
- Author(s)
  Kenmoku, K., Urano, Y., Kanda, K., Kojima, H., Kikuchi, K., Nagano, T.
- Journal Title
  
  Tetrahedron 60
  
  Pages: 11067-11073
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Distinct Glutamate Receptors Govern Differential Levels of Nitric Oxide Production in a Layer-Specific Manner in the Rat Cerebellar Cortex2004
- Author(s)
  Daisuke 0kada, Chan-Choo Yap, Hirotatsu Kojima, Kazuya Kikuchi, Tetsuo Nagano
- Journal Title
  
  Neuroscience 125
  
  Pages: 461-472
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Rational Principles for Modulating Fluorescence Properties of Fluorescein2004
- Author(s)
  Tasuku Ueno, Yasuteru Urano, Ken-ichi Setsukinai, Hideo Takakusa, Hirotatsu Kojima, Kazuya Kikuchi, Kei Ohkubo, Shunichi Fukuzumi, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 126
  
  Pages: 14079-14085
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] A Novel Fluorescent Probe for Zinc Ion Based on BODIPY Chromophore2004
- Author(s)
  Hitomi Koutaka, Jun-ichi Kosuge, Noboru Fukasaku, Tomoya Hirano, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  Chem. Pharm. Bull 52
  
  Pages: 700-703
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Zinc Ion-Selective Luminescent Lanthanide Chemosensor for Biological Applications2004
- Author(s)
  Kenjiro Hanaoka, Kazuya Kikuchi, Hirotatsu Kojima, Yasuteru Urano, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 126
  
  Pages: 12470-12476
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Rational Design of Novel Photoinduced Electron Transfer Type Fluorescent Probes for Sodium Cation2004
- Author(s)
  Suguru Kenmoku, Yasuteru Urano, Koujirou Kanda, Hirotatsu Kojima, Kazuya Kikuchi, Tetsuo Nagano
- Journal Title
  
  Tetrahedron 60
  
  Pages: 11067-11073
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Distinct Glutamate Receptors Govern Differential Levels of Nitric Oxide Production in a Layer-Specific Manner the Rat Cerebellar Cortex2004
- Author(s)
  Okada, D., Yap, C., Kojima, H., Kikuchi, K., Nagano, T.
- Journal Title
  
  Neuroscience 125
  
  Pages: 461-472
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore-Rational Design of Potentially Useful Bioimaging Fluorescence Probe-2004
- Author(s)
  Gabe, Y., Urano, Y., Kikuchi, K, Kojima, H., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 126
  
  Pages: 3357-3367
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] A Novel Fluorescent Probe for Zinc Ion Based on BODIPY Chromophore2004
- Author(s)
  Koutaka, H., Kosuge, J., Fukasaku, N., Hirano, T., Kikuchi, K., Urano, Y., Kojima, H., Nagano, T.
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 52
  
  Pages: 700-703
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene Chromophore -Rational Design of Potentially Useful Bioimaging Fluorescence Probe2004
- Author(s)
  Yu Gabe, Yasuteru Urano, Kazuya Kikuchi, Hirotatsu Kojima, Tetsuo Nagano
- Journal Title
  
  J. Am. Chem. Soc. 126
  
  Pages: 3357-3367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Development of a Zinc Ion-Selective Luminescent Lanthanide Chemosensor for Biological Applications2004
- Author(s)
  Hanaoka, K., Kikuchi, K., Kojima, H., Urano, Y., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 126
  
  Pages: 12470-12476
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Journal Article] Rational Principles for Modulating Fluorescence Properties of Fluorescein2004
- Author(s)
  Ueno, T., Urano, Y., Setsukinai, K., Takakusa, H., Kojima, H., Kikuchi, K., Ohkubo, K., Fukuzumi, K., Nagano, T.
- Journal Title
  
  Journal of the American Chemical Society 126
  
  Pages: 14079-14085
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 活性酸素測定用試薬2009
- Inventor(s)
  長野哲雄、小島宏建、黄色大悲
- Industrial Property Rights Holder
  国立大学法人東京大学
- Filing Date
  2009-02-27
- Data Source
  KAKENHI-PROJECT-20689003
[Patent] 活性酸素測定用試薬2008
- Inventor(s)
  長野哲雄、小島宏建、黄色大悲
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2008-049651
- Filing Date
  2008-02-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 蛍光プローブ2008
- Inventor(s)
  長野哲雄, 小島宏建, 清瀬一貴
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2007-035768
- Filing Date
  2008-02-15
- Overseas
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 蛍光プローブ2008
- Inventor(s)
  長野哲雄、小島宏建、藍澤早希子、清瀬一貴
- Industrial Property Rights Holder
  国立大学法人東京大学
- Filing Date
  2008-02-29
- Description
  「研究成果報告書概要(和文)」より
- Overseas
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 活性酸素測定用試薬2008
- Inventor(s)
  長野哲雄, 小島宏建, 黄色大悲
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2008-049651
- Filing Date
  2008-02-29
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 蛍光プローブ2008
- Inventor(s)
  長野哲雄, 小島宏建, 藍澤早希子, 清瀬一貴
- Industrial Property Rights Holder
  国立大学法人東京大学
- Filing Date
  2008-02-29
- Overseas
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 蛍光プローブ2008
- Inventor(s)
  長野哲雄、小島宏建、清瀬一貴
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2007-035768
- Filing Date
  2008-02-15
- Description
  「研究成果報告書概要(和文)」より
- Overseas
- Data Source
  KAKENHI-PROJECT-16370071
[Patent] 蛍光プローブ2006
- Inventor(s)
  長野哲雄, 小島宏建, 清瀬一貴
- Industrial Property Rights Holder
  長野哲雄, 小島宏建, 清瀬一貴
- Industrial Property Number
  2006-057265
- Filing Date
  2006-03-03
- Data Source
  KAKENHI-PROJECT-17015011
[Patent] 蛍光プローブ2006
- Inventor(s)
  長野哲雄, 小島宏建, 清瀬一貴
- Industrial Property Rights Holder
  長野哲雄, 小島宏建, 清瀬一貴
- Industrial Property Number
  2006-057265
- Filing Date
  2006-03-03
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 新規近赤外蛍光プローブを用いた酸化ストレスのin vivoイメージング2010
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] 新規近赤外蛍光プローブを用いた酸化ストレスの生細胞イメージング2009
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] Development of near-infrared fluorescent probes for nitric oxide and zincion2009
- Author(s)
  Kojima, H., Kiyose, K., Nagano, T
- Organizer
  Optical Imaging 2006
- Place of Presentation
  Bethesda
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] Development of near-infrared fluorescent probes for bioimaging of nitric oxide and reactive oxygen species2009
- Author(s)
  Kojima, H.
- Organizer
  The 5th Joint Meeting of The Societies For Free Radical Research Australasia and Japan
- Place of Presentation
  豪州シドニー
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] In vivoイメージングを目指した活性酸素種検出蛍光プローブの開発2009
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  日本分子イメージング学会第4回学術集会
- Place of Presentation
  東京
- Year and Date
  2009-05-14
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] Development of near-infrared fluorescent probes for bioimaging of nitric oxide and reactive oxygen species.2009
- Author(s)
  Kojima, H.
- Organizer
  The 5th Joint Meeting of The Societies For Free Radical Research Australasia and Japan
- Place of Presentation
  Sydney
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] 新規検出原理に基づいた脂質過酸化物検出蛍光プローブの開発2009
- Author(s)
  冨樫将高, 浦野泰照, 小島宏建, 五十嵐一衛, 長野哲雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] In vivoイメージングを目指した近赤外蛍光プローブの開発2008
- Author(s)
  小島宏建
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 生体に応用可能な活性酸素プローブの開発2008
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] 新規高感度アクロレイン検出蛍光プローブの開発2008
- Author(s)
  冨樫将高, 浦野泰照, 小島宏建, 五十嵐一衛, 長野哲雄
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] シアニン色素の活性酸素感受性の検討とこれに基づく新しい活性酸素検出プローブの開発2008
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  第69回分析化学討論会
- Place of Presentation
  名古屋
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] In vivoイメージングを目指した新規活性酸素プローブの開発2008
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  日本ケミカルバイオロジー研究会第3回年会
- Place of Presentation
  東京
- Year and Date
  2008-05-19
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] 近赤外蛍光プローブの開発に基づく、in vivo消化器官pHモニタリング系の構築2008
- Author(s)
  清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 一酸化窒素および活性酸素種検出蛍光プローブの開発2008
- Author(s)
  小島宏建, 黄色大悲, 佐々木栄太, 西松寛明, 平田恭信, 大崎隆, 古謝玄太, 坂部雅世, 長野哲雄
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-06-19
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] 近赤外領域で測定可能な活性酸素プローブの開発と応用2008
- Author(s)
  黄色大悲, 小島宏建, 長野哲雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 酸化ストレス評価を目的とした新規アクロレイン蛍光プローブの開発2008
- Author(s)
  冨樫将高、浦野泰照、小島宏建、五十嵐一衛、長野哲雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] 酸化ストレス評価を目的とした新規アクロレイン検出法の開発2008
- Author(s)
  冨樫将高, 浦野泰照, 小島宏建, 五十嵐一衛, 長野哲雄
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] In vivoイメージングを目指した活性酸素プローブの開発と応用2008
- Author(s)
  黄色大悲, 小島宏建, 寺井琢也, 長野哲雄
- Organizer
  第3回バイオ関連化学合同シンポジウム
- Place of Presentation
  横浜
- Year and Date
  2008-09-18
- Data Source
  KAKENHI-PROJECT-20689003
[Presentation] シアニン色素の分子内開環/閉環反応機構に関する基礎的検討2008
- Author(s)
  藍澤早希子, 清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] Development of near-infrared fluorescent probes for in vivo bioimaging.2007
- Author(s)
  Kojima, H., Kiyose, K., Aizawa, S. and Nagano, T.
- Organizer
  10th Conference on Methods and Applications of Fluorescence
- Place of Presentation
  オーストリアSalzburg
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 分子プローブによる細胞イメージング2007
- Author(s)
  小島宏建
- Organizer
  薬理学サマーセミナー2007
- Place of Presentation
  三島
- Year and Date
  2007-08-12
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] FRETを制御原理とする近赤外蛍光pHプローブの開発2007
- Author(s)
  藍澤早希子, 清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-09
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] Development of near-infrared fluorescent probes for pH.2007
- Author(s)
  Kojima, H., Kiyose, K., Aizawa, S. and Nagano, T.
- Organizer
  234th ACS National Meeting
- Place of Presentation
  米国Boston
- Year and Date
  2007-08-19
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] アミノシアニンの特性を利用したFRET型近赤外蛍光プローブの開発2007
- Author(s)
  藍澤早希子, 清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  第22回生体機能関連化学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] Development of near-infrared fluorescent probes for nitric oxide and zinc ion2007
- Author(s)
  Kojima, H., Kiyose, K., Sasaki, E., Nishimatsu, H., Hirata, Y., Nagano, T
- Organizer
  BiOS 2007-SPIE Photonics West
- Place of Presentation
  San Jose
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] Development and application of ratiometric fluorescent probes in near-infrared region for in vivo imaging2007
- Author(s)
  Kiyose, K., Kojima, H., Nagano, T.
- Organizer
  Joint Molecular Imaging Conference
- Place of Presentation
  米国Providence
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 一酸化窒素蛍光プローブの開発と応用2007
- Author(s)
  小島宏建
- Organizer
  第7回日本抗加齢医学会総会
- Place of Presentation
  京都
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 近赤外波長変化型蛍光プローブの開発と応用2007
- Author(s)
  清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  日本ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] In vivoイメージングを目指した近赤外波長変化型蛍光プローブの開発2007
- Author(s)
  清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  日本分子イメージング学会第2回学術集会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] 波長変化型近赤外蛍光pHプローブの開発とin vivoイメージングへの応用2007
- Author(s)
  清瀬一貴, 小島宏建, 長野哲雄
- Organizer
  第22回生体機能関連化学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] NOの化学と蛍光プローブの開発2007
- Author(s)
  小島宏建, 長野哲雄
- Organizer
  第29回日本フリーラジカル学会学術集会日本過酸化脂質・フリーラジカル学会第31回大会合同学会
- Place of Presentation
  名古屋
- Year and Date
  2007-06-09
- Data Source
  KAKENHI-PROJECT-17689006
[Presentation] Development of ratiometric near-infrared fluorescent sensors2006
- Author(s)
  Kojima, H., Kiyose, K., Nagano, T
- Organizer
  The 5th Annual Meeting of the Society for Molecular Imaging
- Place of Presentation
  Hawaii
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] フルオレセインを母核とするアクロレイン検出蛍光プローブの開発2006
- Author(s)
  冨樫将高、浦野泰照、小島宏建五十嵐一衛、長野哲雄
- Organizer
  日本薬学会第126年会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] Development of fluorescent probes for nitric oxide as an intercellular messenger2006
- Author(s)
  Kojima, H., Osaki, T., Yamada, R., Ikegaya, Y., Matsuki, N., Nagano, T
- Organizer
  13th Biennial Congress Society for Free Radical Research-International (SFRRI 2006)
- Place of Presentation
  Davos
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071
[Presentation] Development of ratiometric fluorescent sensors with tricarbocyanine chromophore2006
- Author(s)
  Kiyose, K., Kojima, H., Nagano, T
- Organizer
  21st IUPAC Symposium on Photochemistry
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370071

1. NAGANO Tetsuo (20111552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 47 results
2. URANO Yasuteru (20292956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 38 results
3. HIRATA Yasunobu (70167609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. KIKUCHI Kazuya (70292951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results

Kojima Hirotatsu 小島 宏建

KOJIMA Hirotatsu 小島 宏建

Research Projects

Research Products

Co-Researchers

Development of diagnostic imaging reagents based on designing and synthesizing fluorescent probesPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

近赤外蛍光を利用し、生体分子を選択的に促える新規光診断法の開発Principal Investigator

Principal Investigator

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Review Section

Research Institution

近赤外蛍光を利用するバイオイメージングプローブの創製と体内診断薬への展開Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Development of Bioimaging Probes For In Vivo Application

Principal Investigator

Project Period (FY)

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In vivo検出可能な近赤外一酸化窒素感受性蛍光色素の開発研究Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Book] マクマリー生化学反応機構-ケミカルバイオロジーの理解のために-2007

Author(s)

Total Pages

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Description

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[Journal Article] Development and application of a near-infrared fluorescence probe for oxidative stress based on differential reactivity of linked cyanine dyes.2010

Author(s)

Journal Title

Data Source

[Journal Article] Molecular design strategies for near-infrared ratiometric fluorescent probes based on unique spectral properties of aminocyanines.2009

Author(s)

Journal Title

Data Source

[Journal Article] 生体イメージングを目指した近赤外蛍光プローブの開発研究2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase (GST) and application for activity imaging in living cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional Near-Infrared Fluorescent Probes.2008

Author(s)

Journal Title

Data Source

[Journal Article] Functional Near-Infrared Fluorescent Probes2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Functional Near-Infrared Fluorescent Probes2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] A Thiol-Reactive Fluorescence Probe Based on Donor-Excited Photoinduced Electron Transfer:Key Role of Ortho Substituion2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Highly Activatable and Rapidly Releasable Caged Fluorescein Derivatives2007

Author(s)

Journal Title

Kojima Hirotatsu 小島宏建

KOJIMA Hirotatsu 小島宏建