KUWATA TAKEO 桑田岳夫

… Alternative Names

Researcher Number	70346063
Other IDs
Affiliation (Current)	2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 特定事業教員
Affiliation (based on the past Project Information) *help	2019 – 2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 特定事業教員 2018 – 2019: 熊本大学, エイズ学研究センター, 特定事業教員 2017: 熊本大学, エイズ学研究センター, 特任講師 2014 – 2016: 熊本大学, エイズ学研究センター, 助教 2011 – 2012: 熊本大学, エイズ学研究センター, 助教 2010: 熊本大学, 大学院・先導機構, 特任助教
Review Section/Research Field	Principal Investigator Laboratory animal science / Laboratory animal science / Basic Section 42040:Laboratory animal science-related Except Principal Investigator Infectious disease medicine / Basic Section 54030:Infectious disease medicine-related
Keywords	Principal Investigator SIV / アカゲザル / HIV / エイズ / 中和抗体 / モノクローナル抗体 / ウイルス / 感染症 / 免疫学 / antibody … More Except Principal Investigator 感染症治療学 / 感染症防御学 / ウイルス / 内科 / 感染症 / HIV/AIDS / 中和抗体 Less

Identification of broadly neutralizing antibodies to HIV-1 and its correlates with host genetic factorsOngoing
- Principal Investigator
  
  上野貴将
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
SIV感染サルを用いた強力な中和抗体を誘導するメカニズムの解析Principal InvestigatorOngoing
- Principal Investigator
  
  桑田岳夫
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kumamoto University
Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)
- Principal Investigator
  
  Matsushita Shuzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strainsPrincipal Investigator
- Principal Investigator
  
  Kuwata Takeo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Analysis of autoantibodies induced during progression to AIDSPrincipal Investigator
- Principal Investigator
  
  KUWATA Takeo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University

All 2019 2018 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors2019
- Author(s)
  Mamun MA, Kuwata T, Tanaka K, Alam M, Takahama S, Shimura K, Matsuoka M, Fukuda N, Morioka H, Tamamura H, Matsushita S
- Journal Title
  
  Biochemistry and biophysics reports
  
  Volume: 20 Pages: 100687-100687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06032
[Journal Article] The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses2019
- Author(s)
  Thida W, Kuwata T, Maeda Y, Yamashiro T, Tran GV, Nguyen KV, Takiguchi M, Gatanaga H, Tanaka K, Matsushita S
- Journal Title
  
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  
  Volume: 508 Pages: 46-51
- DOI
  10.1016/j.bbrc.2018.11.063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09938, KAKENHI-PROJECT-15H02658, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-18H02854
[Journal Article] Total HIV-1 DNA Dynamics and Influencing Factors in Long-Term ART-Treated Japanese Adults: A Retrospective Longitudinal Analysis2018
- Author(s)
  Stanoeva KR, König A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S.
- Journal Title
  
  Journal of Acquired Immune Deficiency Syndromes
  
  Volume: - Pages: 239-247
- DOI
  10.1097/qai.0000000000001662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09016, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18H02854
[Journal Article] Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes2017
- Author(s)
  T1.Tanaka, K., Kuwata, T., Alam, M., Kaplan., G, Takahama, S., Valdez, K.P.R., Roitburd-Berman, A., Gershoni. J.M., Matsushita, S.
- Journal Title
  
  Retrovirology
  
  Volume: 14 Pages: 44-59
- DOI
  10.1186/s12977-017-0369-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04870
[Journal Article] Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding2016
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Alam, M., Valdez, K. P., Egami, Y., Yoshiaki Suwa, Y., Morioka, H. and Matsushita, S.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 5 Pages: 395-404
- DOI
  10.7883/yoken.jjid.2015.667
  10.7883/yoken.JJID.2015.667
- NAID
  130005416280
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Incompatible natures of HIV-1 envelope in resistance to the CCR5 antagonist cenicriviroc and neutralizing antibodies．2016
- Author(s)
  Kuwata T, Enomoto I, Baba M, Matsushita S
- Journal Title
  
  Antimicrob Agents Chemother.
  
  Volume: 60 Pages: 437-450
- DOI
  10.1128/aac.02285-15
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016
- Author(s)
  Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Ramirez Valdez, K. P., Tanaka, K., Maruta, Y., Oishi, S., Fujii, N., Sato, H., Matsuoka M. and Matsushita S.
- Journal Title
  
  Retrovirology
  
  Volume: 13 Pages: 70-70
- DOI
  10.1186/s12977-016-0304-7
- NAID
  120005973385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15H04870
[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains2015
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Virology
  
  Volume: 475 Pages: 187-203
- DOI
  10.1016/j.virol.2014.11.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-26430091
[Journal Article] Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques2015
- Author(s)
  Guo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago ML
- Journal Title
  
  Immunogenetics
  
  Volume: 67 Pages: 355-370
- DOI
  10.1007/s00251-015-0844-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Journal Article] Conformational epitope consisting of theV3 and V4 loops as a target for potent andbroad neutralization of simianimmunodeficiency viruses2013
- Author(s)
  Kuwata T, Takaki K, Yoshimura K,Enomoto I, Wu F, Ourmanov I, Hirsch VM,Yokoyama M, Sato H, Matsushita S
- Journal Title
  
  J Virol
  
  Volume: 87(10) Pages: 5424-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Journal Article] Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses2013
- Author(s)
  Kuwata T
- Journal Title
  
  Journal of Virology
  
  Volume: in press Pages: 5424-5436
- DOI
  10.1128/jvi.00201-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PUBLICLY-25115519
[Journal Article] Isolation of potentneutralizing monoclonal antibodies froman SIV-Infected rhesus macaque by phagedisplay2011
- Author(s)
  Kuwata T, Katsumata Y, Takaki K, MiuraT, Igarashi T
- Journal Title
  
  AIDS Res Hum Retroviruses
  
  Volume: 27(5) Pages: 487-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Journal Article] Isolation of Potent Neutralizing Monoclonal Antibodies from an SIV-Infected Rhesus Macaque by Phage Display2011
- Author(s)
  Kuwata, T.
- Journal Title
  
  AIDS RESEARCH AND HUMAN RETROVIRUSES
  
  Volume: 27 Pages: 487-500
- DOI
  10.1089/aid.2010.0191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300152, KAKENHI-PROJECT-22500387
[Journal Article] Isolation of Potent Neutralizing Monoclonal Antibodies from an SIV-Infected Rhesus Macaque by Phage Display2010
- Author(s)
  桑田岳夫
- Journal Title
  
  AIDS RESEARCH AND HUMAN RETROVIRUSES
  
  Volume: Vol 26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Patent] 抗ＨＩＶ抗体の製造方法2018
- Inventor(s)
  松下修三; 桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Holder
  松下修三; 桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-203114
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Polymorphism of Immunoglobulin germline gene restricts induction of bnAbs against SIV2019
- Author(s)
  Kuwata T
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Role of Conventional Antibodies in Control of HIV-1 CRF01_AE viruses2018
- Author(s)
  Thida W, Kuwata T, Maeda Y, Tran G V, Nguyen K V, Takiguchi M, Gatanaga H and Matsushita S
- Organizer
  HIV Research for Prevention 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Analysis of the envelope gene in the patient treated with maraviroc2018
- Author(s)
  Lin K H, Kuwata T, Thida W, Shimizu M and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] 抗HIV治療薬ドルテグラビル、マラビロクを含むcART中に出現した耐性ウイルスの解析2018
- Author(s)
  桑田岳夫、Kaung Htet Lin、蜂谷敦子、Win Thida、中田浩智、岩谷靖雅、吉村和久、松下修三
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Synergistic inhibition by single chain fragment variables and fusion inhibitors in both cell-free and cell-associated HIV-1 infections2018
- Author(s)
  Mamun M A, Maruta Y, Tanaka K, Alam M, Thida W, Takahama S, Kuwata T and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] 抗イディオタイプ抗体による抗V3中和単クローン抗体産生B細胞単離方法の検討2018
- Author(s)
  郭悠、桑田岳夫、田中和樹、Biswas Shashwata、Zahid MD Hassan、松下修三
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Single cell sorting による抗 V3 中和単クローン抗体に対する抗イディオタイプ.2017
- Author(s)
  郭悠, 桑田岳夫, 田中和樹, Alam Mohammad Mamun, 高濱正吉, Hassan MD Zahid, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and Neutralization Potency and coverage of anti-V3 scFv’sagainst HIV-1 subtype-B viruses.2017
- Author(s)
  Alam Mohammad, 田中和樹, Muntasir Alam, Win Thida, 桑田岳夫, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and kinetics, Neutralization Potency and Coverage of anti-V3 scFv’s against HIV-1 Subtype-B viruses in vitro.2017
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida, W., Kuwata T., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Neutralization sensitivities of clade B and CRF01_AE viruses of HIV-1 isolated from patients with recent diagnosis in Japan.2017
- Author(s)
  Thida, W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimizu, M., Kawanami, Y., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Dynamics of HIV-1 DNA in long-term treated patients with hematological co-morbidities2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Isolation and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis.2016
- Author(s)
  Thida W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimuzu M., Kawanami Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro2016
- Author(s)
  Mamun M, Maruta Y, Tanaka K, Alam M, Thida W, Kuwata T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies Boston, Massachusetts.2016
- Author(s)
  Kuwata,T., Enomoto I., Baba M., Matsushita S.
- Organizer
  Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] PM1/CCR5 cells transduced with T312 Intrabody have survival advantage, if challenged with SF162 HIV-1 strain2016
- Author(s)
  Alves G, Kuwata T, Tanaka Y, Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] CD4+T細胞の分化に対するHIV感染とmiR125bの影響の検討2016
- Author(s)
  郭悠、南留美、小松真梨子、高濱宗一郎、高濱正吉、桑田岳夫、山本政弘、松下修三
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies2016
- Author(s)
  Kuwata T, Enomoto I, Baba M and Matsushita S
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Analysis and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis2016
- Author(s)
  Thida W, Kuwata T, Alam M, Tanaka K, Maun M, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Increased total HIV DNA levels in long-term treated patients with hemophilia.2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y., Matsushita S.
- Organizer
  第30回日本エイズ学会学術集会・総会.
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Total HIV DNA levels dynamics upon ART initiation2016
- Author(s)
  Stanoeva KR., Konig A., Fukuda A., Kawanami Y., Kuwata T., Satou Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on long-term ART2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  2016 Towards an HIV Cure Symposium
- Place of Presentation
  Durban, South Africa
- Year and Date
  2016-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on longterm ART2016
- Author(s)
  K. Stanoeva, A. Konig, A. Fukuda, Y. Kawanami, T. Kuwata, Y. Satou, S. Matsushita.
- Organizer
  21st International AIDS Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro.2016
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida W., Kuwata T., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Post-attachment neutralization of a broad range of HIV-1 strains by the small antibody fragments targeting CD4-induced (CD4i) epitope2016
- Author(s)
  Tanaka K, Kuwata T, Takahama S, Alam M, Maruta Y, Ramirez Valdez K P, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Post-attachment Neutralization of a Wide Range of HIV-1 Strains by Anti-CD4i Single Chain Variable Fragment (scFv)2016
- Author(s)
  Tanaka K, Kuwata T, Maruta Y, Ramirez Valdez K P, Alam M, Kawanami Y, Matsushita S
- Organizer
  HIVR4P 2016
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Induction of antibodies, which belonged to the same class as broadly neutralizing antibody B404, in macaques infected with SIVsmH635FC2016
- Author(s)
  Kuwata T, Sano M, Matsuoka S, Shimizu M, Miura T, Seki Y, Akari H, Matano T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody reactive against a conformational epitope of SIV gp1202015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Effect of gp41 mutations on the sensitivity to neutralizing antibodies against HIV.2015
- Author(s)
  Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.
- Organizer
  第29回日本エイズ学会学術集会・総会.
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope.2015
- Author(s)
  Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S.
- Organizer
  The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015)
- Place of Presentation
  Vancouver, Canada.
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Impact of gp41 mutations for escape from a broad neutralizing antibody against SIV2015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  16th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析.2015
- Author(s)
  平田泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] CRF01_AE HIV-1 感染症例IgG の交差中和活性の解析2012
- Author(s)
  園田貴丈、Samatchaya Boonchawalit、田中和樹、丸田康広、Kristel Ramirez、桑田岳夫、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する2012
- Author(s)
  桑田岳夫
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIV 感染サルから分離された中和抗体 B404 は V3,V4ループを含む Env 立体構造を認識する2012
- Author(s)
  桑田岳夫、吉村和久、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] gp120 のCD4-induced epitope に結合する中和抗体の解析2012
- Author(s)
  田中和樹、桑田岳夫、丸田泰広、園田貴丈、Kristel Ramirez 、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-26
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Conformational epitope inbolving V3 and V4 loops is a major tartget for antibody-mediated neutralization in SIV smH635-infected macaques.2012
- Author(s)
  Kuwata T.
- Organizer
  13th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  阿蘇グランヴィリオホテル、熊本県阿蘇市
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Isolation of Potent Neutralizing Monoclonal Antibodies against V3 Loop from SIV-infected Macaques2011
- Author(s)
  桑田岳夫
- Organizer
  AIDS Vaccine 2011
- Place of Presentation
  Bangkok Convention Centre (Bangkok, Thai)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIVsmH635FC感染サルにおける特定のエピトープと遺伝子に偏った中和抗体の誘導2011
- Author(s)
  桑田岳夫
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京(東京都)
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Biased induction of neutralizing antibodies with particular specificity and gene usage in SIVsmH635FC-infected macaques2011
- Author(s)
  桑田岳夫
- Organizer
  12th Kumamoto AIDS Seminar
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(熊本県)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Generation of monoclonal antibodies with potent neutralizing activity from a SIV-infected macaque2010
- Author(s)
  桑田岳夫
- Organizer
  The 28th Annual Symposium for Nonhuman Primate Models for AIDS
- Place of Presentation
  Westin New Orleans Canal Place (New Orleans, USA)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Contribution of antibody response to effective viral suppression and progression of disvease during SIV infection2010
- Author(s)
  桑田岳夫
- Organizer
  International Young Investigator Symposium
- Place of Presentation
  熊本大学(熊本県)
- Year and Date
  2010-04-04
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] ファーシ・ティスプレイ法による強力な抗SIV中和活性をもつモノクローナル抗体の作製2010
- Author(s)
  桑田岳夫
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  あわぎんホール(徳島県)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Isolation of monoclonal neutralizing antibodies from SIV-infected macaques by phage display2010
- Author(s)
  桑田岳夫
- Organizer
  11th Kumamoto AIDS Seminar
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(熊本県)
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIVサル・モデルを用いた中和抗体の解析
- Author(s)
  桑田岳夫
- Organizer
  第17回日本レトロウイルス研究会夏期セミナー
- Place of Presentation
  伊豆山研修センター(静岡県熱海市)
- Year and Date
  2014-07-03 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] 強力な抗SIV中和抗体B404からの逃避メカニズムの解析
- Author(s)
  桑田岳夫、松下修三
- Organizer
  第28回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪国際会議場（大阪府北区）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Mutations in gp41 is Critical to Escape from B404, a Broad Neutralizing Antibody Against SIV, Which Recognizes a V3/V4 Conformational Epitope
- Author(s)
  Takeo Kuwata, Kazuhisa Yoshimura, Fan Wu, Ilnour Ourmanov, Vanessa M. Hirsch, Masaru Yokoyama, Hironori Sato and Shuzo Matsushita
- Organizer
  32nd Annual Symposium on Nonhuman Primate Models for AIDS
- Place of Presentation
  The Nines Hotel (Portland, Oregon, USA)
- Year and Date
  2014-11-11 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-26430091

1. IGARASHI Tatsuhiko (90467431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. MATSUSHITA Shuzo (00199788)

# of Collaborated Projects: 2 results

# of Collaborated Products: 34 results
3. 佐藤賢文 (70402807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 上野貴将 (10322314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉村和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 横山勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤井信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大石真也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 前田洋助

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 滝口雅文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐藤裕徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUWATA TAKEO 桑田 岳夫

Kuwata Takeo 桑田 岳夫

KUWATA Takeo 桑田 岳夫

Research Projects

Research Products

Co-Researchers

Identification of broadly neutralizing antibodies to HIV-1 and its correlates with host genetic factorsOngoing

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SIV感染サルを用いた強力な中和抗体を誘導するメカニズムの解析Principal InvestigatorOngoing

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Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)

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Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strainsPrincipal Investigator

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Analysis of autoantibodies induced during progression to AIDSPrincipal Investigator

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[Journal Article] Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors2019

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[Journal Article] The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses2019

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[Journal Article] Total HIV-1 DNA Dynamics and Influencing Factors in Long-Term ART-Treated Japanese Adults: A Retrospective Longitudinal Analysis2018

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[Journal Article] Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes2017

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[Journal Article] Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding2016

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[Journal Article] Incompatible natures of HIV-1 envelope in resistance to the CCR5 antagonist cenicriviroc and neutralizing antibodies．2016

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[Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016

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NAID

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[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains2015

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Data Source

[Journal Article] Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques2015

KUWATA TAKEO 桑田岳夫

Kuwata Takeo 桑田岳夫

KUWATA Takeo 桑田岳夫

[Presentation] Single cell sorting による抗 V3 中和単クローン抗体に対する抗イディオタイプ.2017