KUWATA TAKEO 桑田岳夫

… Alternative Names

Kuwata Takeo 桑田岳夫

KUWATA Takeo 桑田岳夫

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Researcher Number	70346063
Other IDs
Affiliation (Current)	2025: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 特任准教授 2019 – 2020: 熊本大学, ヒトレトロウイルス学共同研究センター, 特定事業教員 2018: 熊本大学, エイズ学研究センター, 特定事業教員 2017: 熊本大学, エイズ学研究センター, 特任講師 2014 – 2016: 熊本大学, エイズ学研究センター, 助教 2011 – 2012: 熊本大学, エイズ学研究センター, 助教 2010: 熊本大学, 大学院・先導機構, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Laboratory animal science Except Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine
Keywords	Principal Investigator アカゲザル / SIV / HIV / 抗体 / 中和抗体 / エイズ / シングルセル / RNA-seq / カニクイザル / SHIV … More / single cell RNA-seq / 寛解 / 遺伝子多型 / ワクチン / vaccine / antibody / 免疫学 / 感染症 / ウイルス / モノクローナル抗体 … More Except Principal Investigator HIV/AIDS / 中和抗体 / HIV感染症 / Tanzania / neutralizing antibody / HIV-1 / 感染症 / 内科 / ウイルス / 感染症防御学 / 感染症治療学 Less

Analysis of remission mechanism by administration of anti-HIV antibody using single cell RNA-seqPrincipal Investigator
- Principal Investigator
  
  Kuwata Takeo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kumamoto University
Identification of broadly neutralizing antibodies to HIV-1 and its correlates with host genetic factors
- Principal Investigator
  
  UENO Takamasa
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kumamoto University
Analysis of mechanism to induce potent neutralizing antibodies using SIV-infected macaquesPrincipal Investigator
- Principal Investigator
  
  Kuwata Takeo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kumamoto University
Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)
- Principal Investigator
  
  Matsushita Shuzo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Kumamoto University
Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strainsPrincipal Investigator
- Principal Investigator
  
  Kuwata Takeo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University
Analysis of autoantibodies induced during progression to AIDSPrincipal Investigator
- Principal Investigator
  
  KUWATA Takeo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kumamoto University

[Journal Article] Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV2024
- Author(s)
  Ngare Isaac、Tan Toong Seng、Toyoda Mako、Kuwata Takeo、Takahama Soichiro、Nakashima Eriko、Yamasaki Naoya、Motozono Chihiro、Fujii Teruhisa、Minami Rumi、Barabona Godfrey、Ueno Takamasa
- Journal Title
  
  Viruses
  
  Volume: 16 Issue: 4 Pages: 555-555
- DOI
  10.3390/v16040555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05989
[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023
- Author(s)
  Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4 Pages: 00660-23
- DOI
  10.1128/spectrum.00660-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
[Journal Article] Idiotopes of antibodies against <scp>HIV</scp>‐1 <scp>CD4</scp>‐induced epitope shared with those against microorganisms2023
- Author(s)
  Biswas Shashwata、Kuwata Takeo、Yamauchi Soichiro、Okazaki Kyo、Kaku Yu、Hasan Md Zahid、Morioka Hiroshi、Matsushita Shuzo
- Journal Title
  
  Immunology
  
  Volume: 171 Issue: 4 Pages: 534-548
- DOI
  10.1111/imm.13742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05989
[Journal Article] Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates2023
- Author(s)
  Matsumoto Kaho、Kuwata Takeo、Tolbert William D.、Richard Jonathan、Ding Shilei、Prevost Jeremie、Takahama Shokichi、Judicate George P.、Ueno Takamasa、Nakata Hirotomo、Kobayakawa Takuya、Tsuji Kohei、Tamamura Hirokazu、Smith Amos B.、Pazgier Marzena、Finzi Andres、Matsushita Shuzo
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 1
- DOI
  10.1128/jvi.01638-22
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-22K15243, KAKENHI-PROJECT-20H03362, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K19657
[Journal Article] Development and characterization of a panel of anti-idiotype antibodies to 1C10 that cross-neutralize HIV-1 subtype B viruses2022
- Author(s)
  Kaku Yu、Matsumoto Kaho、Kuwata Takeo、Zahid Hasan Md、Biswas Shashwata、Gorny Miroslaw K.、Matsushita Shuzo
- Journal Title
  
  Frontiers in Virology
  
  Volume: 2 Pages: 932187-932187
- DOI
  10.3389/fviro.2022.932187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970
[Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021
- Author(s)
  Matsuoka Saori、Kuwata Takeo、Ishii Hiroshi、Sekizuka Tsuyoshi、Kuroda Makoto、Sano Masato、Okazaki Midori、Yamamoto Hiroyuki、Shimizu Mikiko、Matsushita Shuzo、Seki Yohei、Saito Akatsuki、Sakawaki Hiromi、Hirsch Vanessa M.、Miura Tomoyuki、Akari Hirofumi、Matano Tetsuro
- Journal Title
  
  Journal of Virology
  
  Volume: 95 Issue: 7
- DOI
  10.1128/jvi.02455-20
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02666, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K07157, KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989
[Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021
- Author(s)
  Kobayakawa Takuya、Tsuji Kohei、Konno Kiju、Himeno Ai、Masuda Ami、Yang Tingting、Takahashi Kohei、Ishida Yusuke、Ohashi Nami、Kuwata Takeo、Matsumoto Kaho、Yoshimura Kazuhisa、Sakawaki Hiromi、Miura Tomoyuki、Harada Shigeyoshi、Matsushita Shuzo、Tamamura Hirokazu
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 3 Pages: 1481-1496
- DOI
  10.1021/acs.jmedchem.0c01153
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15951, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18K08458, KAKENHI-PROJECT-19K22488, KAKENHI-PROJECT-19H03146, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K08501
[Journal Article] Neutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Neutralization-Resistant SIVsmE543-3 Infection2021
- Author(s)
  Nomura Yuto、Matsuoka Saori、Okazaki Midori、Kuwata Takeo、Matano Tetsuro、Ishii Hiroshi
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 6 Pages: 1181-1181
- DOI
  10.3390/v13061181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02745, KAKENHI-PROJECT-21K05989
[Journal Article] Phenotypic and Genotypic Co-receptor Tropism Testing in HIV-1 Epidemic Region of Tanzania Where Multiple Non-B Subtypes Co-circulate2021
- Author(s)
  Judicate George P.、Barabona Godfrey、Kamori Doreen、Mahiti Macdonald、Tan Toong Seng、Ozono Seiya、Mgunya Amina Shaban、Kuwata Takeo、Matsushita Shuzo、Sunguya Bruno、Lyamuya Eligius、Tokunaga Kenzo、Ueno Takamasa
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 12 Pages: 703041-703041
- DOI
  10.3389/fmicb.2021.703041
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21K07060, KAKENHI-PROJECT-21K19657
[Journal Article] Existence of replication-competent minor variants with different coreceptor usage in plasma from HIV-1-infected individuals2020
- Author(s)
  Maeda Y, Takemura T, Chikata T, Kuwata T, Terasawa H, Fujimoto R, Kuse N, Akahoshi T, Murakoshi H, Van Tran G, Zhang Y, Pham CH, Pham AHQ, Monde K, Sawa T, Matsushita S, Nguyen TV, Van Nguyen K, Hasebe F, Yamashiro T, Takiguchi M.
- Journal Title
  
  Journal of Virology
  
  Volume: 94 Issue: 12
- DOI
  10.1128/jvi.00193-20
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-16K09938, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032
[Journal Article] Prediction of Contact Residues in Anti-HIV Neutralizing Antibody by Deep Learning2020
- Author(s)
  Kaku Yu、Kuwata Takeo、Gorny Miroslaw K.、Matsushita Shuzo
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 73 Issue: 3 Pages: 235-241
- DOI
  10.7883/yoken.JJID.2019.496
- NAID
  130007845455
- ISSN
  1344-6304, 1884-2836
- Year and Date
  2020-05-29
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-18K06032
[Journal Article] Synergistic inhibition of cell-to-cell HIV-1 infection by combinations of single chain variable fragments and fusion inhibitors2019
- Author(s)
  Mamun MA, Kuwata T, Tanaka K, Alam M, Takahama S, Shimura K, Matsuoka M, Fukuda N, Morioka H, Tamamura H, Matsushita S
- Journal Title
  
  Biochemistry and biophysics reports
  
  Volume: 20 Pages: 100687-100687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06032
[Journal Article] The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses.2019
- Author(s)
  Thida W, Kuwata T, Maeda Y, Yamashiro T, Tran GV, Nguyen KV, Takiguchi M, Gatanaga H, Tanaka K, Matsushita S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 508 Issue: 1 Pages: 46-51
- DOI
  10.1016/j.bbrc.2018.11.063
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09938, KAKENHI-PROJECT-15H02658, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-18H02854, KAKENHI-PROJECT-16H02775
[Journal Article] Total HIV-1 DNA dynamics and influencing factors in long-term ART-treated Japanese adults: a retrospective longitudinal analysis.2018
- Author(s)
  Stanoeva KR, König A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S.
- Journal Title
  
  J Acquir Immune Defic Syndr
  
  Volume: - Issue: 2 Pages: 239-247
- DOI
  10.1097/qai.0000000000001662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09016, KAKENHI-PROJECT-15H04870, KAKENHI-PROJECT-18K06032, KAKENHI-PROJECT-18H02854
[Journal Article] Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes2017
- Author(s)
  T1.Tanaka, K., Kuwata, T., Alam, M., Kaplan., G, Takahama, S., Valdez, K.P.R., Roitburd-Berman, A., Gershoni. J.M., Matsushita, S.
- Journal Title
  
  Retrovirology
  
  Volume: 14 Issue: 1 Pages: 44-59
- DOI
  10.1186/s12977-017-0369-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04870
[Journal Article] Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies2016
- Author(s)
  Kuwata T, Enomoto I, Baba M, Matsushita S
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 60 Issue: 1 Pages: 437-450
- DOI
  10.1128/aac.02285-15
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Cross-Neutralization Activity of Single-Chain Variable Fragment (scFv) Derived from Anti-V3 Monoclonal Antibodies Mediated by Post-Attachment Binding2016
- Author(s)
  Maruta, Y., Kuwata, T., Tanaka, K., Alam, M., Valdez, K. P., Egami, Y., Yoshiaki Suwa, Y., Morioka, H. and Matsushita, S.
- Journal Title
  
  Jpn J Infect Dis
  
  Volume: 69 Issue: 5 Pages: 395-404
- DOI
  10.7883/yoken.JJID.2015.667
- NAID
  130005416280
- ISSN
  1344-6304, 1884-2836
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-15H04870
[Journal Article] Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors2016
- Author(s)
  Alam, M., Kuwata, T., Shimura, K., Yokoyama, M., Ramirez Valdez, K. P., Tanaka, K., Maruta, Y., Oishi, S., Fujii, N., Sato, H., Matsuoka M. and Matsushita S.
- Journal Title
  
  Retrovirology
  
  Volume: 13 Issue: 1 Pages: 70-70
- DOI
  10.1186/s12977-016-0304-7
- NAID
  120005973385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430091, KAKENHI-PROJECT-16K08824, KAKENHI-PROJECT-15H04654, KAKENHI-PROJECT-15H04870
[Journal Article] Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains.2015
- Author(s)
  Ramirez, K.P., Kuwata, T., Maruta, Y, Tanaka K., Muntasir, A., Yoshimura, K., Matsushita, S.
- Journal Title
  
  Virology
  
  Volume: 475 Pages: 187-203
- DOI
  10.1016/j.virol.2014.11.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PROJECT-26430091
[Journal Article] Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques2015
- Author(s)
  Guo K, Halemano K, Schmitt K, Katuwal M, Wang Y, Harper MS, Heilman KJ, Kuwata T, Stephens EB, Santiago ML
- Journal Title
  
  Immunogenetics
  
  Volume: 67 Issue: 7 Pages: 355-370
- DOI
  10.1007/s00251-015-0844-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Journal Article] Conformational epitope consisting of theV3 and V4 loops as a target for potent andbroad neutralization of simianimmunodeficiency viruses2013
- Author(s)
  Kuwata T, Takaki K, Yoshimura K,Enomoto I, Wu F, Ourmanov I, Hirsch VM,Yokoyama M, Sato H, Matsushita S
- Journal Title
  
  J Virol
  
  Volume: 87(10) Pages: 5424-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Journal Article] Conformational epitope consisting of the V3 and V4 loops as a target for potent and broad neutralization of simian immunodeficiency viruses.2013
- Author(s)
  Kuwata T
- Journal Title
  
  J Virol.
  
  Volume: in press Issue: 10 Pages: 933-943
- DOI
  10.1128/jvi.00201-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387, KAKENHI-PROJECT-24591484, KAKENHI-PROJECT-24591485, KAKENHI-PUBLICLY-25115519
[Journal Article] Isolation of potent neutralizing monoclonal antibodies from an SIV-Infected rhesus macaque by phage display.2011
- Author(s)
  Kuwata, T.
- Journal Title
  
  AIDS Res. Hum. Retroviruses
  
  Volume: 27 Issue: 5 Pages: 487-500
- DOI
  10.1089/aid.2010.0191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300152, KAKENHI-PROJECT-22500387
[Journal Article] Isolation of potentneutralizing monoclonal antibodies froman SIV-Infected rhesus macaque by phagedisplay2011
- Author(s)
  Kuwata T, Katsumata Y, Takaki K, MiuraT, Igarashi T
- Journal Title
  
  AIDS Res Hum Retroviruses
  
  Volume: 27(5) Pages: 487-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Journal Article] Isolation of Potent Neutralizing Monoclonal Antibodies from an SIV-Infected Rhesus Macaque by Phage Display2010
- Author(s)
  桑田岳夫
- Journal Title
  
  AIDS RESEARCH AND HUMAN RETROVIRUSES
  
  Volume: Vol 26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500387
[Patent] コロナウイルス変異株に対するヒト抗体またはその抗原結合断片2023
- Inventor(s)
  松下修三;郭悠;桑田岳夫;河岡義裕;今井正樹;山吉誠也
- Industrial Property Rights Holder
  松下修三;郭悠;桑田岳夫;河岡義裕;今井正樹;山吉誠也
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21K05989
[Patent] 抗HIV-1 V3抗体1C10（0.5γ）に結合する抗体及びその抗原結合断片並びにその応用2021
- Inventor(s)
  松下修三、郭悠、桑田岳夫
- Industrial Property Rights Holder
  松下修三、郭悠、桑田岳夫
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21K05989
[Patent] 抗HIV抗体の製造方法2021
- Inventor(s)
  松下修三；桑田岳夫；清水　衛；冨田正浩；道下眞弘
- Industrial Property Rights Holder
  松下修三；桑田岳夫；清水　衛；冨田正浩；道下眞弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-553897
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21K05989
[Patent] 抗ＨＩＶ抗体の製造方法2018
- Inventor(s)
  松下修三; 桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Holder
  松下修三; 桑田岳夫; 清水　衛; 冨田正浩; 道下眞弘
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-203114
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] SARS-CoV-2 Delta株ブレイクスルー感染例から分離した抗体の交差中和活性2023
- Author(s)
  桑田岳夫、郭悠、清水美紀子、 Biswas Shashwata、松本佳穂、 Khairy Hamdy Edri Ahmed、松下修三
- Organizer
  日本エイズ学会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] SARS-CoV-2 Delta株ブレイクスルー感染例から分離した中和抗体の解析2023
- Author(s)
  桑田岳夫
- Organizer
  日本抗ウイルス療法学会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] CD4類似化合物YIR-821は多くのHIV-1臨床株に有効である2022
- Author(s)
  松本佳穂, 桑田岳夫 ,高濱正吉 , George P Judicate, 上野貴将, 小早川拓也, 玉村啓和 , 松下修三
- Organizer
  日本エイズ学会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] 中和抗体抵抗性SIV感染サルにおいて免疫グロブリン遺伝子多型が中和抗体誘導に及ぼす影響の解析2021
- Author(s)
  野村柚仁、松岡佐織、岡崎みどり、桑田岳夫、俣野哲郎、石井洋
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] CD4類似化合物YIR-821によるサブタイプB HIV-1患者抗体の活性増強効果2021
- Author(s)
  松本佳穂、桑田岳夫、Zahid Md H、郭悠、Biswas S、高濱正吉、玉村啓和、松下修三
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] Plasma IL-21 associates with HIV-1 Neutralizing Potency of polyclonal IgG in the periphery2021
- Author(s)
  Isaac Ngare, Takeo Kuwata, Godfrey Barabona, Takamasa Ueno
- Organizer
  11th IAS Conference on HIV Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703
[Presentation] Maraviroc less sensitive HIV-1 variants in a region where multiple non-B subtypes co-circulate2021
- Author(s)
  George P. Judicate, Godfrey Barabona, Doreen Kamori, Macdonald Mahiti, Takeo Kuwata, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
- Organizer
  HIV research for prevention (HIVR4P)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03703
[Presentation] Anti-Idiotype antibodies as sorting probes to isolate anti-CD4i antibodies2021
- Author(s)
  Biswas S, Yamauchi S, Morioka H, Kaku Y, Kuwata T, Matsushita S
- Organizer
  第35回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-21K05989
[Presentation] Functional characterization of HIV-1 envelopes from Tanzania where multiple non-B co-circulates2020
- Author(s)
  George P. Judicate, Godfrey Barabona, Doreen Kamori, Macdonald Mahiti, Takeo Kuwata, Bruno Sunguya, Eligius Lyamuya, Takamasa Ueno
- Organizer
  第34回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03703
[Presentation] Polymorphism of Immunoglobulin germline gene restricts induction of bnAbs against SIV2019
- Author(s)
  Kuwata T
- Organizer
  第33回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Synergistic inhibition by single chain fragment variables and fusion inhibitors in both cell-free and cell-associated HIV-1 infections2018
- Author(s)
  Mamun M A, Maruta Y, Tanaka K, Alam M, Thida W, Takahama S, Kuwata T and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] 抗HIV治療薬ドルテグラビル、マラビロクを含むcART中に出現した耐性ウイルスの解析2018
- Author(s)
  桑田岳夫、Kaung Htet Lin、蜂谷敦子、Win Thida、中田浩智、岩谷靖雅、吉村和久、松下修三
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] 抗イディオタイプ抗体による抗V3中和単クローン抗体産生B細胞単離方法の検討2018
- Author(s)
  郭悠、桑田岳夫、田中和樹、Biswas Shashwata、Zahid MD Hassan、松下修三
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Role of Conventional Antibodies in Control of HIV-1 CRF01_AE viruses2018
- Author(s)
  Thida W, Kuwata T, Maeda Y, Tran G V, Nguyen K V, Takiguchi M, Gatanaga H and Matsushita S
- Organizer
  HIV Research for Prevention 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Analysis of the envelope gene in the patient treated with maraviroc2018
- Author(s)
  Lin K H, Kuwata T, Thida W, Shimizu M and Matsushita S
- Organizer
  第32回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K06032
[Presentation] Single cell sorting による抗 V3 中和単クローン抗体に対する抗イディオタイプ.2017
- Author(s)
  郭悠, 桑田岳夫, 田中和樹, Alam Mohammad Mamun, 高濱正吉, Hassan MD Zahid, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Neutralization sensitivities of clade B and CRF01_AE viruses of HIV-1 isolated from patients with recent diagnosis in Japan.2017
- Author(s)
  Thida, W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimizu, M., Kawanami, Y., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and Neutralization Potency and coverage of anti-V3 scFv’sagainst HIV-1 subtype-B viruses.2017
- Author(s)
  Alam Mohammad, 田中和樹, Muntasir Alam, Win Thida, 桑田岳夫, 松下修三.
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Evaluation of Binding affinity and kinetics, Neutralization Potency and Coverage of anti-V3 scFv’s against HIV-1 Subtype-B viruses in vitro.2017
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida, W., Kuwata T., Matsushita S.
- Organizer
  18th Kumamoto AIDS seminar.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Dynamics of HIV-1 DNA in long-term treated patients with hematological co-morbidities2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Post-attachment Neutralization of a Wide Range of HIV-1 Strains by Anti-CD4i Single Chain Variable Fragment (scFv)2016
- Author(s)
  Tanaka K, Kuwata T, Maruta Y, Ramirez Valdez K P, Alam M, Kawanami Y, Matsushita S
- Organizer
  HIVR4P 2016
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies2016
- Author(s)
  Kuwata T, Enomoto I, Baba M and Matsushita S
- Organizer
  The annual Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Analysis and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis2016
- Author(s)
  Thida W, Kuwata T, Alam M, Tanaka K, Maun M, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on longterm ART2016
- Author(s)
  K. Stanoeva, A. Konig, A. Fukuda, Y. Kawanami, T. Kuwata, Y. Satou, S. Matsushita.
- Organizer
  21st International AIDS Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] PM1/CCR5 cells transduced with T312 Intrabody have survival advantage, if challenged with SF162 HIV-1 strain2016
- Author(s)
  Alves G, Kuwata T, Tanaka Y, Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] HIV proviral DNA quantification in a cohort of Japanese patients on long-term ART2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y, Matsushita S
- Organizer
  2016 Towards an HIV Cure Symposium
- Place of Presentation
  Durban, South Africa
- Year and Date
  2016-07-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Induction of antibodies, which belonged to the same class as broadly neutralizing antibody B404, in macaques infected with SIVsmH635FC2016
- Author(s)
  Kuwata T, Sano M, Matsuoka S, Shimizu M, Miura T, Seki Y, Akari H, Matano T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Total HIV DNA levels dynamics upon ART initiation2016
- Author(s)
  Stanoeva KR., Konig A., Fukuda A., Kawanami Y., Kuwata T., Satou Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Increased total HIV DNA levels in long-term treated patients with hemophilia.2016
- Author(s)
  Stanoeva K, Konig A, Fukuda A, Kawanami Y, Kuwata T, Satou Y., Matsushita S.
- Organizer
  第30回日本エイズ学会学術集会・総会.
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Incompatibility of HIV-1 Resistance to Both Cenicriviroc and Neutralizing Antibodies Boston, Massachusetts.2016
- Author(s)
  Kuwata,T., Enomoto I., Baba M., Matsushita S.
- Organizer
  Conference on Retroviruses and Opportunistic Infections
- Place of Presentation
  Boston, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro2016
- Author(s)
  Mamun M, Maruta Y, Tanaka K, Alam M, Thida W, Kuwata T and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] CD4+T細胞の分化に対するHIV感染とmiR125bの影響の検討2016
- Author(s)
  郭悠、南留美、小松真梨子、高濱宗一郎、高濱正吉、桑田岳夫、山本政弘、松下修三
- Organizer
  第30回日本エイズ学会学術集会・総会
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Isolation and characterization of HIV-1 envelope glycoprotein in Japanese patients with recent diagnosis.2016
- Author(s)
  Thida W., Kuwata T., Muntasir A., Tanaka K., Mamun M., Shimuzu M., Kawanami Y., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Post-attachment neutralization of a broad range of HIV-1 strains by the small antibody fragments targeting CD4-induced (CD4i) epitope2016
- Author(s)
  Tanaka K, Kuwata T, Takahama S, Alam M, Maruta Y, Ramirez Valdez K P, Shimizu M, Kawanami Y and Matsushita S
- Organizer
  17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Construction, purification and analysis of neutralization potency of anti-V3 scFv’s against HIV-1 strains in vitro.2016
- Author(s)
  Mamun M., Maruta Y., Tanaka K., Muntasir A., Thida W., Kuwata T., Matsushita S.
- Organizer
  2nd Kumamoto IRCMS International Symposium.17th Kumamoto AIDS seminar
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Potent and broad neutralizing activity of small antibody fragments targeting CD4i (CD4-induced) epitope.2015
- Author(s)
  Tanaka, K., Kuwata, T., Maruta, Y., Ramirez, K., Alam, M., Egami, Ikumi Y., Enomoto, I., Kawanami, Y., Matsushita. S.
- Organizer
  The 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015)
- Place of Presentation
  Vancouver, Canada.
- Year and Date
  2015-07-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Impact of gp41 mutations on resistance to B404, a broad neutralizing antibody reactive against a conformational epitope of SIV gp1202015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Effect of gp41 mutations on the sensitivity to neutralizing antibodies against HIV.2015
- Author(s)
  Muntasir, A., Kuwata, T., Ramirez, K., Maruta, Y., Tanaka, K., Shimura, K., Oishi, S., Fujii, N., Matsuoka, M., Matsushita, S.
- Organizer
  第29回日本エイズ学会学術集会・総会.
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] ファージ・ライブラリーを用いた抗 V3単クローン抗体のエピトープ解析.2015
- Author(s)
  平田泉、桑田岳夫、丸田泰広、田中和樹、Muntasir, A.、松下修三
- Organizer
  第29回日本エイズ学会学術集会・総会
- Place of Presentation
  東京ドームホテル、東京
- Year and Date
  2015-11-30
- Data Source
  KAKENHI-PROJECT-15H04870
[Presentation] Impact of gp41 mutations for escape from a broad neutralizing antibody against SIV2015
- Author(s)
  Kuwata T, Shimizu M, Matsushita S
- Organizer
  16th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] SIV感染サルから分離された中和抗体B404はV3,V4ループを含むEnv立体構造を認識する2012
- Author(s)
  桑田岳夫
- Organizer
  第26回日本エイズ学会学術集会・総会
- Place of Presentation
  慶應義塾大学日吉キャンパス、横浜市
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] CRF01_AE HIV-1 感染症例IgG の交差中和活性の解析2012
- Author(s)
  園田貴丈、Samatchaya Boonchawalit、田中和樹、丸田康広、Kristel Ramirez、桑田岳夫、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIV 感染サルから分離された中和抗体 B404 は V3,V4ループを含む Env 立体構造を認識する2012
- Author(s)
  桑田岳夫、吉村和久、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] gp120 のCD4-induced epitope に結合する中和抗体の解析2012
- Author(s)
  田中和樹、桑田岳夫、丸田泰広、園田貴丈、Kristel Ramirez 、松下修三
- Organizer
  第26回日本エイズ学会学術集会
- Place of Presentation
  横浜慶應義塾大学
- Year and Date
  2012-11-26
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Conformational epitope inbolving V3 and V4 loops is a major tartget for antibody-mediated neutralization in SIV smH635-infected macaques.2012
- Author(s)
  Kuwata T.
- Organizer
  13th Kumamoto AIDS Seminar GCOE Joint International Symposium
- Place of Presentation
  阿蘇グランヴィリオホテル、熊本県阿蘇市
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIVsmH635FC感染サルにおける特定のエピトープと遺伝子に偏った中和抗体の誘導2011
- Author(s)
  桑田岳夫
- Organizer
  第25回日本エイズ学会学術集会
- Place of Presentation
  ハイアットリージェンシー東京(東京都)
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Isolation of Potent Neutralizing Monoclonal Antibodies against V3 Loop from SIV-infected Macaques2011
- Author(s)
  桑田岳夫
- Organizer
  AIDS Vaccine 2011
- Place of Presentation
  Bangkok Convention Centre (Bangkok, Thai)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Biased induction of neutralizing antibodies with particular specificity and gene usage in SIVsmH635FC-infected macaques2011
- Author(s)
  桑田岳夫
- Organizer
  12th Kumamoto AIDS Seminar
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(熊本県)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Contribution of antibody response to effective viral suppression and progression of disvease during SIV infection2010
- Author(s)
  桑田岳夫
- Organizer
  International Young Investigator Symposium
- Place of Presentation
  熊本大学(熊本県)
- Year and Date
  2010-04-04
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Isolation of monoclonal neutralizing antibodies from SIV-infected macaques by phage display2010
- Author(s)
  桑田岳夫
- Organizer
  11th Kumamoto AIDS Seminar
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル(熊本県)
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] ファーシ・ティスプレイ法による強力な抗SIV中和活性をもつモノクローナル抗体の作製2010
- Author(s)
  桑田岳夫
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  あわぎんホール(徳島県)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] Generation of monoclonal antibodies with potent neutralizing activity from a SIV-infected macaque2010
- Author(s)
  桑田岳夫
- Organizer
  The 28th Annual Symposium for Nonhuman Primate Models for AIDS
- Place of Presentation
  Westin New Orleans Canal Place (New Orleans, USA)
- Year and Date
  2010-10-19
- Data Source
  KAKENHI-PROJECT-22500387
[Presentation] SIVサル・モデルを用いた中和抗体の解析
- Author(s)
  桑田岳夫
- Organizer
  第17回日本レトロウイルス研究会夏期セミナー
- Place of Presentation
  伊豆山研修センター(静岡県熱海市)
- Year and Date
  2014-07-03 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] 強力な抗SIV中和抗体B404からの逃避メカニズムの解析
- Author(s)
  桑田岳夫、松下修三
- Organizer
  第28回日本エイズ学会学術集会・総会
- Place of Presentation
  大阪国際会議場（大阪府北区）
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26430091
[Presentation] Mutations in gp41 is Critical to Escape from B404, a Broad Neutralizing Antibody Against SIV, Which Recognizes a V3/V4 Conformational Epitope
- Author(s)
  Takeo Kuwata, Kazuhisa Yoshimura, Fan Wu, Ilnour Ourmanov, Vanessa M. Hirsch, Masaru Yokoyama, Hironori Sato and Shuzo Matsushita
- Organizer
  32nd Annual Symposium on Nonhuman Primate Models for AIDS
- Place of Presentation
  The Nines Hotel (Portland, Oregon, USA)
- Year and Date
  2014-11-11 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-26430091

1. IGARASHI Tatsuhiko (90467431)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. MATSUSHITA Shuzo (00199788)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
3. UENO Takamasa (10322314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 佐藤賢文 (70402807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 前田洋助

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 俣野哲朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 辻耕平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUWATA TAKEO 桑田 岳夫

Kuwata Takeo 桑田 岳夫

KUWATA Takeo 桑田 岳夫

Research Projects

Research Products

Co-Researchers

Analysis of remission mechanism by administration of anti-HIV antibody using single cell RNA-seqPrincipal Investigator

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Identification of broadly neutralizing antibodies to HIV-1 and its correlates with host genetic factors

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Analysis of mechanism to induce potent neutralizing antibodies using SIV-infected macaquesPrincipal Investigator

Principal Investigator

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Research toward elimination of HIV persistent infected cells remaining under antiretroviral therapy (ART)

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Development of antibody-inducing vaccine models by analysis of B404 which neutralizes various SIV strainsPrincipal Investigator

Principal Investigator

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Analysis of autoantibodies induced during progression to AIDSPrincipal Investigator

Principal Investigator

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[Journal Article] Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV2024

Author(s)

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[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023

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[Journal Article] Idiotopes of antibodies against <scp>HIV</scp>‐1 <scp>CD4</scp>‐induced epitope shared with those against microorganisms2023

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[Journal Article] Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates2023

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[Journal Article] Development and characterization of a panel of anti-idiotype antibodies to 1C10 that cross-neutralize HIV-1 subtype B viruses2022

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[Journal Article] A Potent Anti-Simian Immunodeficiency Virus Neutralizing Antibody Induction Associated with a Germ Line Immunoglobulin Gene Polymorphism in Rhesus Macaques2021

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[Journal Article] Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors2021

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[Journal Article] Neutralizing Antibody Induction Associated with a Germline Immunoglobulin Gene Polymorphism in Neutralization-Resistant SIVsmE543-3 Infection2021

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KUWATA TAKEO 桑田岳夫

Kuwata Takeo 桑田岳夫

KUWATA Takeo 桑田岳夫