Ishihara Tsutomu 石原務

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ISHIHARA Tsutomu 石原務

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Researcher Number	70349554
Other IDs
Affiliation (Current)	2025: 日本大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 日本大学, 工学部, 教授 2010 – 2012: 日本大学, 工学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering / Biomedical engineering/Biological material science
Keywords	Principal Investigator ナノ粒子 / ポリ乳酸 / DDS / 細胞内デリバリー / 脂質修飾 / 抗体医薬 / 慢性動脈閉塞症 / miRNA / 核酸医薬 / AMO … More / オリゴ核酸 / 血管新生 / アンチmiRNAオリゴ核酸 / 生分解性ポリマー / ドラッグデリバリー / タンパク医薬 / 化学修飾 / 酵素 / バイオ医薬 / 抗体 / ＤＤＳ / レシチン / バイオベター / 遺伝子治療 / 薬物送達システム / siRNA / ポリプレックス / 核酸デリバリー / C型肝炎 / リバビリン / Ｃ型肝炎 / ナノメディスン / ナノバイオロジー Less

細胞内抗原を標的とした新型抗体医薬の開発Principal Investigator
- Principal Investigator
  
  石原務
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nihon University
Treatment of chronic arterial occlusion with biodegradable nanoparticles encapsulating anti-miRNA oligonucleotidesPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Tsutomu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nihon University
Development of lecithin-modified therapeutic proteins as biobettersPrincipal Investigator
- Principal Investigator
  
  Ishihara Tsutomu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nihon University
Development of multifunctional polyplexes without polycationsPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Tsutomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Nihon University
Establishment of novel therapy for hepatitis C by double DDS drugsPrincipal Investigator
- Principal Investigator
  
  ISHIHARA Tsutomu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Nihon University

[Book] 新規モダリティ医薬品のためのDDS技術とその製剤化2023
- Author(s)
  石原務他
- Total Pages
  580
- Publisher
  技術情報協会
- ISBN
  9784861049361
- Data Source
  KAKENHI-PROJECT-20K12654
[Journal Article] Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery2017
- Author(s)
  Kihara Y, Maeda R, Imaizumi A, Ichikawa T, Nemoto N, Ishihara T, Hirano N, and Haruki M.
- Journal Title
  
  J. Nanosci. Nanotechnol.
  
  Volume: 17 Issue: 7 Pages: 5081-5089
- DOI
  10.1166/jnn.2017.13121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350532, KAKENHI-PROJECT-17K01395
[Journal Article] Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity2017
- Author(s)
  Kaneko K, Ishihara T.
- Journal Title
  
  Cogent Medicine
  
  Volume: 4 Issue: 1 Pages: 1418133-1418133
- DOI
  10.1080/2331205x.2017.1418133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01395
[Journal Article] Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells2016
- Author(s)
  Ishihara T, Shibui M, Hoshi T, Mizushima T
- Journal Title
  
  Molecular BioSystems
  
  Volume: 12 Issue: 1 Pages: 274-282
- DOI
  10.1039/c5mb00631g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350532
[Journal Article] Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.2015
- Author(s)
  Ishihara, T., Hayashi, E., Yamamoto, S., Kobayashi, C., Tamura, Y., Sawazaki, R., Tamura, F., Tahara, K., Kasahara, T., Ishihara, T., Takenaga, M., Fukuda, K. and Mizushima, T
- Journal Title
  
  J. Control. Release
  
  Volume: 97 Pages: 97-104
- DOI
  10.1016/j.jconrel.2014.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524, KAKENHI-PROJECT-26460104, KAKENHI-PROJECT-26350532
[Journal Article] Development of biodegradable nanoparticles for liver-specific ribavirin delivery. J2014
- Author(s)
  Ishihara, T., Kaneko, K., Ishihara, T. and Mizushima, T
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 103 Issue: 12 Pages: 4005-4011
- DOI
  10.1002/jps.24219
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524, KAKENHI-PROJECT-26350532
[Journal Article] Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions.2014
- Author(s)
  Kihara Y, Ichikawa T, Abe S, Nemoto N, Ishihara T, Hirano N, Haruki M.
- Journal Title
  
  Polymer Journal
  
  Volume: 46 Issue: 3 Pages: 175-183
- DOI
  10.1038/pj.2013.86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350532
[Journal Article] Interactions of Lecithinized Superoxide Dismutase with Serum Proteins and Cells.2014
- Author(s)
  Ishihara T, Nara S, Mizushima T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 103 Issue: 7 Pages: 1987-1994
- DOI
  10.1002/jps.24031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26350532
[Journal Article] Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication2013
- Author(s)
  Ishihara T
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Fluorescent nucleosides with 'on-off' switching function, pH-responsive fluorescent uridine derivatives.2012
- Author(s)
  Saito Y, Miyamoto S, Suzuki A, Matsumoto K, Ishihara T, Saito I.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 15 Pages: 2753-2756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] (N-isopropylacrylamide)-PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake.2012
- Author(s)
  Ayano E, Karaki M, Ishihara T, KanazawaH, Okano T. Poly
- Journal Title
  
  Colloids Surf B Biointerfaces.
  
  Volume: 99 Pages: 67-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Therapeutic effect of stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate on experimental autoimmune uveoretinitis.2011
- Author(s)
  Sakai T., Ishihara T., Higaki M.,Akiyama G., Tsuneoka H.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 52 Pages: 1516-1521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates2011
- Author(s)
  Ishihara Tsutomu, et al
- Journal Title
  
  J Control Release
  
  Volume: 155 Issue: 1 Pages: 34-39
- DOI
  10.1016/j.jconrel.2010.10.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Nuclear localization and antisense effect of PNA internalized by ASGP-R-mediated endocytosis with protein/DNA conjugates.2011
- Author(s)
  Ishihara T., Kano A., Obara K., Saito M., Chen X., Park T.G., Akaike T., Maruyama A.
- Journal Title
  
  J Control Release
  
  Volume: 155 Pages: 34-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Stealth-nanoparticle strategy for enhancing the efficacy of steroids in mice with noise-induced hearing loss.2010
- Author(s)
  Horie R., Sakamoto T., Nakagawa T., Ishihara T., Higaki M., Ito J.
- Journal Title
  
  Nanomedicine(Lond)
  
  Volume: 5 Pages: 1331-40
- NAID
  120004184965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatory agents2010
- Author(s)
  Ishihara Tsutomu, et al.
- Journal Title
  
  Int.J.Pharm.
  
  Volume: 385 Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers2010
- Author(s)
  Ishihara Tsutomu, et al.
- Journal Title
  
  Biomacromolecules
  
  Volume: 11 Pages: 2700-2706
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles.2010
- Author(s)
  Ishihara T., Mizushima T.
- Journal Title
  
  Exp. Opinion on Drug Deliv.
  
  Volume: 7 Pages: 565-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation andsustained release.2010
- Author(s)
  Takenaga M, Ishihara T, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Mizushima T.
- Journal Title
  
  J Control. Release
  
  Volume: 148 Pages: 249-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Techniques for efficient entrapment of pharmaceuticals in biodegradable solid micro/nanoparticles2010
- Author(s)
  Ishihara Tsutomu, et al.
- Journal Title
  
  Exp.Opinion on Drug Deliv
  
  Volume: 7 Pages: 565-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.2010
- Author(s)
  Ishihara T., Maeda T., Sakamoto H., Takasaki N., Shigyo M., Ishida T., Kiwada H., Mizushima Y., Mizushima T.
- Journal Title
  
  Biomacromolecules
  
  Volume: 11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Preparation and characterization of a nanoparticulate formulation composed of PEG-PLA and PLA as anti-inflammatoryagents.2010
- Author(s)
  T. Ishihara, M. Takahashi, M. Higaki, Y. Mizushima, and T. Mizushima
- Journal Title
  
  Int.J. Pharm.
  
  Volume: 385 Pages: 170-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) on bleomycin-induced pulmonary fibrosis.2010
- Author(s)
  Tanaka KI., Ishihara T., Azuma A., Kudoh S., Ebina M., Nukiwa T., Sugiyama Y., Tasaka Y., Namba T., Ishihara T., Sato K., Mizushima Y., Mizushima T.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Journal Article] Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental ratmodel of intermittent claudication
- Author(s)
  Ishihara T, Takasaki N, Yamamoto S, Hayashi E, Takenaga M, Yamakawa N, Ishihara T, Mizushima T.
- Journal Title
  
  Journal of Pharmacy and Pharmacology.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500410
[Patent] 薬物を封入した肝臓集積性ナノ粒子2011
- Inventor(s)
  石原務、水島徹
- Industrial Property Rights Holder
  石原務、水島徹
- Industrial Property Number
  2011-192838
- Filing Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 骨ターゲティングを目指したペプチド修飾ポリ乳酸ナノ粒子の開発2022
- Author(s)
  山本真大、田口天志、室野井実紀、内野智裕、石原務
- Organizer
  2022年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] Biodegradable polymer nanoparticles for drug delivery2022
- Author(s)
  石原務
- Organizer
  2021年度化学系学協会東北大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] ペプチドを表面に修飾した機能性ポリ乳酸ナノ粒子の作製2022
- Author(s)
  室野井実紀、宮下侑子、伊藤悟、安田京磨、石原務
- Organizer
  2021年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] RGDペプチドを修飾したポリ乳酸ナノ粒子の調製とその核酸医薬への応用2022
- Author(s)
  田口天志、山本真大、山田賢伸、室野井実紀、伊藤悟、石原務
- Organizer
  2022年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] 機能性ポリ乳酸ナノ粒子の調製とその核酸医薬への応用2022
- Author(s)
  田口天志、山本真大、山田賢伸、室野井実紀、伊藤悟、石原務
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] 薬物放出速度制御とターゲッテイング能を有するポリ乳酸ナノ粒子の作製2020
- Author(s)
  安田京磨、吉田拓弥、石原務
- Organizer
  2020高分子学会東北支部研究発表会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] オリゴ核酸を封入したポリ乳酸ナノ粒子の開発2020
- Author(s)
  伊藤悟、佐藤佳純、佐藤仁美、石原務
- Organizer
  2020高分子学会東北支部研究発表会
- Data Source
  KAKENHI-PROJECT-20K12654
[Presentation] ホスファチジルコリンを化学修飾したタンパク質の合成とその活性評価2019
- Author(s)
  宗方泉稀、松本安平、星貴也、澁井美咲、石原務
- Organizer
  2019年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-17K01395
[Presentation] ホスファチジルコリンを化学修飾したタンパク質の合成とその活性評価2018
- Author(s)
  松本安平、星貴也、澁井美咲、水島徹、石原務
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-17K01395
[Presentation] 肝星細胞特異的薬物デリバーを目指した生分解性ナノ粒子の開発2017
- Author(s)
  山下勇一、齋藤菜美恵、石原務
- Organizer
  第66回高分子学会年次大会
- Place of Presentation
  幕張メッセ（千葉県千葉市）
- Year and Date
  2017-05-29
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] ポリカチオンを用いない核酸内包高分子ナノ粒子の開発2016
- Author(s)
  佐藤佳純、石原務
- Organizer
  2016高分子学会東北支部研究発表会
- Place of Presentation
  山形大学（山形県米沢市）
- Year and Date
  2016-11-10
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] 肝硬変治療を目指したセレコキシブ封入ナノ粒子の開発2016
- Author(s)
  山下勇一、齋藤菜美恵、石原務
- Organizer
  第59回日本大学工学部学術研究報告会
- Place of Presentation
  日本大学（福島県郡山市）
- Year and Date
  2016-12-03
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] 肝指向性高分子ナノ粒子の開発2015
- Author(s)
  金子昂平、石原務
- Organizer
  第64回高分子学会討論会
- Place of Presentation
  東北大学
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] 肝炎治療を目指したリバビリン封入高分子ナノ粒子の開発2015
- Author(s)
  金子昂平、石原務、水島徹
- Organizer
  第31回日本DDS学会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2015-07-03
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] 肝炎治療を目指したリバビリン封入ナノ粒子の開発2013
- Author(s)
  石原務
- Organizer
  第29回日本DDS学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 合成高分子を用いたナノ粒子型DDS製剤の開発2012
- Author(s)
  石原務、平野展孝、斉藤義雄、春木満、宇野茂之、槇島誠
- Organizer
  平成24年度化学系学協会東北大会
- Place of Presentation
  秋田
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 合成高分子を用いたナノ粒子型DDS製剤の開発2012
- Author(s)
  石原務
- Organizer
  化学系学協会東北大会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] リバビリンを封入した肝細胞特異的高分子ナノ粒子の開発2012
- Author(s)
  石原務、平野展孝、斉藤義雄、春木満、宇野茂之、槇島誠、水島徹
- Organizer
  第61回高分子学会討論会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] PVP被覆ナノ粒子によるABC現象の回避2010
- Author(s)
  石原務
- Organizer
  第59回高分子学会年次大会
- Place of Presentation
  横浜
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 合成高分子の医薬品への利用2010
- Author(s)
  石原務
- Organizer
  東北ポリマー懇話会
- Place of Presentation
  郡山
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 生分解性高分子を用いたナノ粒子製剤の開発2010
- Author(s)
  石原務
- Organizer
  平成22年度化学系学協会東北大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 水島徹PVP被覆ナノ粒子によるABC現象の回避2010
- Author(s)
  石原務、前田泰司、高崎奈央子
- Organizer
  第59回高分子学会年次大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] DDS材料2010
- Author(s)
  石原務
- Organizer
  第27回医用高分子研究会講座
- Place of Presentation
  東京
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-22500410
[Presentation] 肝炎治療を目指したリバビリン封入高分子ナノ粒子の開発
- Author(s)
  金子昂平,石原務
- Organizer
  平成26年度化学系学協会東北大会
- Place of Presentation
  山形
- Year and Date
  2014-09-21 – 2014-09-22
- Data Source
  KAKENHI-PROJECT-26350532
[Presentation] 薬物放出速度を制御可能な生分解性高分子ナノ粒子の開発
- Author(s)
  石原務
- Organizer
  第３０回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-26350532

1. 水島徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Ishihara Tsutomu 石原 務

ISHIHARA Tsutomu 石原 務

Research Projects

Research Products

Co-Researchers

細胞内抗原を標的とした新型抗体医薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment of chronic arterial occlusion with biodegradable nanoparticles encapsulating anti-miRNA oligonucleotidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of lecithin-modified therapeutic proteins as biobettersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of multifunctional polyplexes without polycationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel therapy for hepatitis C by double DDS drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新規モダリティ医薬品のためのDDS技術とその製剤化2023

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Alkyne-functionalized cationic polysiloxane polymers conjugated with targeting molecules by click reactions for DNA delivery2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of liver-specific ribavirin-loaded nanoparticles with reduced cytotoxicity2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Scavenging of superoxide anions by lecithinized superoxide dismutase in HL-60 cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of biodegradable nanoparticles for liver-specific ribavirin delivery. J2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of alkyne-functionalized amphiphilic polysiloxane polymers and formation of nanoemulsions conjugated with bioactive molecules by click reactions.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interactions of Lecithinized Superoxide Dismutase with Serum Proteins and Cells.2014

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DOI

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[Journal Article] Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication2013

Author(s)

Journal Title

Data Source

Ishihara Tsutomu 石原務

ISHIHARA Tsutomu 石原務