OCHI Kozo 越智幸三

… Alternative Names

越智幸三オチコウゾウ

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Researcher Number	70353985
Other IDs
Affiliation (based on the past Project Information) *help	2013: 広島工業大学, その他部局等, 教授 2012: 広島工業大学, 生命学部, 教授 2010 – 2011: 広島工業大学, 情報学部, 教授 2008: National Agricultural Research Organization, 食品総合研究所食品バイオテクノロジー研究領域, ユニット長 2008: National Agricultural Research Organization, 食品総合研究所食品バイオテクノロジー研究領域生物機能解析ユニット, ユニット長 … More 2007: National Agricultural Research Organization, 食品総合研究所・食品バイオテクノロジー研究領域, ユニット長 2006: 独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所食品バイオテクノロジー研究領域, ユニット長 2005: 独立行政法人食品総合研究所, 生物機能開発部, 室長 Less
Review Section/Research Field	Principal Investigator Applied microbiology
Keywords	Principal Investigator 放線菌 / RNAポリメラーゼ / 希土類元素 / 微生物育種 / 微生物遺伝 / 休眠遺伝子 / 微生物遺伝・育種 / Thermus thermophilus / ppGpp / Thermus … More / 枯草菌 / 緊縮制御 / 抗生物質 / 二次代謝 / 転写制御 / 遺伝子 / 発酵 / 応用微生物 Less

Development of the technology to activate actinomycete silent genesPrincipal Investigator
- Principal Investigator
  
  OCHI Kozo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Hiroshima Institute of Technology
Activation of dormant ability by modulating RNA polymerase and global clarification of transcription mechanismPrincipal Investigator
- Principal Investigator
  
  越智幸三
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  National Agricultural Research Organization
  National Food Research Institute

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book

[Book] 微生物の「休眠遺伝子」を活性化し抗生物質などを作り出す技術を開発、ブレインテクノニュース2007
- Author(s)
  越智幸三
- Data Source
  KAKENHI-PROJECT-17380058
[Book] From microbial differentiation to ribosome engineering. Biosci. Biotechnol. Biochem.2007
- Author(s)
  Ochi, K.
- Data Source
  KAKENHI-PROJECT-17380058
[Book] リボゾーム工学による微生物からの有用物質発見、月刊バイオインダストリー2007年10月号2007
- Author(s)
  保坂毅、王国君、岡本晋、越智幸三
- Data Source
  KAKENHI-PROJECT-17380058
[Book] 微生物の二次代謝に生理的意義はあるのか? 抗生物質生産の新たな意味を探る、化学と生物2007
- Author(s)
  越智幸三、稲岡隆史
- Data Source
  KAKENHI-PROJECT-17380058
[Book] 蛋白質核酸酵素2005
- Author(s)
  戸澤譲, 越智幸三
- Total Pages
  1
- Publisher
  共立出版株式会社
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size2014
- Author(s)
  Tojo S, Kim JY, Tanaka Y, Inaoka T, Hiraga Y, Ochi K.
- Journal Title
  
  J Bacteriol
  
  Volume: 196 Issue: 8 Pages: 1514-1524
- DOI
  10.1128/jb.01441-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055, KAKENHI-PROJECT-24510298
[Journal Article] Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements2014
- Author(s)
  Ochi K, Tanaka Y, Tojo S
- Journal Title
  
  J Ind Microbiol Biotechnol
  
  Volume: 41 Issue: 2 Pages: 403-414
- DOI
  10.1007/s10295-013-1349-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] New strategies for drug discovery : activation of silent or weakly expressed microbial gene clusters2013
- Author(s)
  Ochi K, Hosaka T
- Journal Title
  
  Appl Microbiol Biotechnol
  
  Volume: 97 Issue: 1 Pages: 87-98
- DOI
  10.1007/s00253-012-4551-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Chromosomal circularization of the model Streptomyces species, Streptomyces coelicolor A(3).2013
- Author(s)
  Nindita, Y., T. Nishikawa, K. Arakawa, G. Wang, K. Ochi, Z. Qin, and H. Kinashi.
- Journal Title
  
  FEMS Microbiol. Lett.
  
  Volume: 347 Pages: 149-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] rRNA (rrn)operon-engineered Bacillus subtilis as a feasible test organism for antibiotic discovery2013
- Author(s)
  Tanaka Y, Nanamiya H, Yano K, Kakugawa K, Kawamura F, Ochi K
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 57 Issue: 4 Pages: 1948-1951
- DOI
  10.1128/aac.02604-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055, KAKENHI-PROJECT-22570005
[Journal Article] New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters2013
- Author(s)
  Kozo Ochi Takeshi Hosaka
- Journal Title
  
  Applied Microbiology and Biotechnology
  
  Volume: 97 Pages: 87-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] rRNA(rrn)Operon-Engineered Bacillus subtilis as a Feasible Test Organism for Antibiotic Discovery2013
- Author(s)
  Yukinori　Tanaka Hideaki Nanamiya Koichi Yano Koji Kakugawa Fujio Kawamura Kozo Ochi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 57 Pages: 1948-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes2013
- Author(s)
  Tanaka Y, Kasahara K, Hirose Y, Murakami K, Kugimiya R, Ochi K
- Journal Title
  
  J Bacteriol
  
  Volume: 195 Issue: 13 Pages: 2959-2970
- DOI
  10.1128/jb.00147-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Structure and biosynthesis of scabichelin a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.222013
- Author(s)
  Kodani S, Bicz J, Song L, Deeth RJ, Ohnishi-kameyama M, Yoshida M, Ochi K, Challis GL
- Journal Title
  
  Org Biomol Chem
  
  Volume: 11 Issue: 28 Pages: 4686-4694
- DOI
  10.1039/c3ob40536b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Chromosomal circularization of the model Streptomyces species2013
- Author(s)
  Nindita Y, Nishikawa T, Arakawa K, Wang G, Ochi K, Qin Z, Kinashi H
- Journal Title
  
  Streptomyces coelicolor A3(2). FEMS Microbiol Lett
  
  Volume: 347 Pages: 149-155
- DOI
  10.1111/1574-6968.12228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055, KAKENHI-PUBLICLY-25108718, KAKENHI-PROJECT-25450155
[Journal Article] A magic bullet for antibiotic discovery2012
- Author(s)
  Ochi K, Okamoto S
- Journal Title
  
  Chem Biol
  
  Volume: 19 Issue: 8 Pages: 932-934
- DOI
  10.1016/j.chembiol.2012.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements2012
- Author(s)
  Inaoka T, Ochi K
- Journal Title
  
  J Bacteriol
  
  Volume: 194 Pages: 5632-5637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] A Magic Bullet for Antibiotic Discovery2012
- Author(s)
  Kozo Ochi Susummu Okamoto
- Journal Title
  
  Chemistry & Biology
  
  Volume: 19 Pages: 932-934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Development of the ability to producesecondary metabolites in Streptomyces through the acquisition of erythromycin resistance2012
- Author(s)
  Imai, Y., Fujiwara, T., Ochi K., Hosaka, T.
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: (in press) Issue: 6 Pages: 323-326
- DOI
  10.1038/ja.2012.16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780068, KAKENHI-PROJECT-22380055
[Journal Article] Heterologous expression of a plant RelA-SpoT homologue results in increased stress tolerance in Scaccharomyces cerevisiae by accumulation of the bacterial alarmone ppGpp2012
- Author(s)
  Kozo Ochi Tomoyasu Nishizawa Takashi Inaoka Akiyo YAmada Kohsuke Hashimoto Takeshi Hosaka Susumu Okamoto Yoshishiro Ozeki
- Journal Title
  
  Microbiology
  
  Volume: 158 Pages: 2213-2224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Heterologous expression of a plant RelA-SpoT homologue results in increased stress tolerance in Saccharomyces cerevisiae by accumulation of the bacterial alarmone ppGpp2012
- Author(s)
  Ochi K, Nishizawa T, Inaoka T, Yamada A, Hashimoto K, Hosaka T, Okamoto S, Ozeki Y
- Journal Title
  
  Microbiology
  
  Volume: 158 Issue: 8 Pages: 2213-2224
- DOI
  10.1099/mic.0.057638-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055, KAKENHI-PROJECT-23370016, KAKENHI-PROJECT-24657026
[Journal Article] Crystal Structure Analysis of the Translation Factor RF3 (release factor 3)2012
- Author(s)
  K. Kihira, Y. Shimizu, Y. Shomura, N. Shibata, M. Kitamura, A. Nakagawa, T. Ueda, K. Ochi, Y.Higuchi
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Issue: 20 Pages: 3705-3709
- DOI
  10.1016/j.febslet.2012.08.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370061, KAKENHI-PROJECT-22380055, KAKENHI-PROJECT-24657077
[Journal Article] Crystal structure analysis of the translation factor PF3 (release factor 3)2012
- Author(s)
  Kiyohito Kihira Yoshihiro Shimizu Yasuhito Shomura Naoki Shibata Masaya Kitamura Atsushi Nakagawa Takuya Ueda Kozo Ochi Yoshiki Higuchi
- Journal Title
  
  FEBS Lettrs
  
  Volume: 586 Pages: 3705-3709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Undecaprenyl Pyrophosphate Involment in Susceptibility of Bacillus subtilis to Rare Earth Elements2012
- Author(s)
  Takeshi Inaoka Kozo Ochi
- Journal Title
  
  Journal of Bacteriology
  
  Volume: 194 Pages: 5632-5637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis2011
- Author(s)
  Takashi Inaoka, Kozo Ochi
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 77 Pages: 8181-8183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] New siderophore isolated from Streptomyces sp.TM-34 with potent inhibitory activity against angiotensin-converting enzyme2011
- Author(s)
  Shinya Kodani, Mayumi Ohnishi-Kameyama, Mitsuru Yoshida , Kozo ochi
- Journal Title
  
  The European Journal of Organic Chemistry
  
  Volume: DOI :10.1002/ejoc.200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis2011
- Author(s)
  Inaoka T, Ochi K
- Journal Title
  
  Appl Environ Microbiol
  
  Volume: 77 Issue: 22 Pages: 8181-8183
- DOI
  10.1128/aem.06205-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055, KAKENHI-PROJECT-22780078
[Journal Article] Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis2011
- Author(s)
  Inaoka T, Ochi K
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 75 Pages: 618-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] The G243D mutation (afsB mutation) in the principal sigma factor sigmaHrdB alters intracellular ppGpp level and antibiotic production in Streptomyces coelicolor A3(2)2010
- Author(s)
  Wang G, Tanaka Y, Ochi K
- Journal Title
  
  Microbiology
  
  Volume: 156 Issue: 8 Pages: 2384-2392
- DOI
  10.1099/mic.0.039834-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Rare earth elements active the secondary metabolite-biosynthetic clusters in Streptomyces coelicolor A3(2)2010
- Author(s)
  Yukinori Tanaka, Takeshi Hosaka, Kozo Ochi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 63 Pages: 477-481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] The G243D mutation (afsB mutation) in the principal sigma factor alters intracellular ppGpp level and antibiotic production in Streptomyces coelicolor A3(2)2010
- Author(s)
  Guojun Wang, Yukinori Tanaka, Kozo Ochi
- Journal Title
  
  Microbiology
  
  Volume: 156 Pages: 2384-2392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Rare earth elements activate the secondary metabolite-biosynthesis gene clusters in Streptomyces coelicolor A3(2)2010
- Author(s)
  Tanaka Y., Hosaka T. and Ochi K
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: Vol.63 Issue: 8 Pages: 477-481
- DOI
  10.1038/ja.2010.53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21780068, KAKENHI-PROJECT-22380055
[Journal Article] Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 80892010
- Author(s)
  Fukuda K, Tamura T, Ito H, Yamamoto S, Ochi K, Inagaki K
- Journal Title
  
  J Biosci Bioeng
  
  Volume: 109 Issue: 5 Pages: 459-465
- DOI
  10.1016/j.jbiosc.2009.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22380055
[Journal Article] Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.2009
- Author(s)
  Hosaka, T., M. Ohnishi-Kameyama, H. Muramatsu, K. Murakami, Y. Tsurumi, S. Kodani, M. Yoshida, A. Fujie, K. Ochi
- Journal Title
  
  Nature Biotechnology 27
  
  Pages: 462-464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Inactivation of KsgA, a 16S rRNA Methyltransferase, Causes Vigorous Emergence of Mutants with High-Level Kasugamycin Resistance2009
- Author(s)
  K Ochi, J Kim, Y Tanaka, G Wang, K Masuda, H Nanamiya, S Okamoto, S Tokuyama, Y Adachi, F Kawamura
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 53
  
  Pages: 193-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Biosynthesis of Actinorhodin and Related Antibiotics : Discovery of Alternative Routes for quinine Formation Encoded in the act Gene Cluster2009
- Author(s)
  S Okamoto, T Taguchi, K Ochi, K Ichinose
- Journal Title
  
  Chemistry & Biology 16
  
  Pages: 226-237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Inactivation of KsgA, 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance.2009
- Author(s)
  Ochi, K., J-Y. Kim., Y. Tanaka, G. Wang, K. Masuda, H. Nanamiya, S. Okamoto, S. Tokuyasu, Y. Adachi, F. Kawamura.
- Journal Title
  
  Antimicrob. Agents Chemother. 53
  
  Pages: 193-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Identification and Characterization of a Novel Multidrug Resistance Operon2009
- Author(s)
  Kim, J. Y. T. Inaoka, K. Hirooka, H. Matsuoka, M. Murata, R. Ohki, Y. Adachi, Y. Fujita, K. Ochi.
- Journal Title
  
  mdtRP (yusOP) of Bacillus subtilis. 191
  
  Pages: 3273-3281
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Activation of dormant genes by Nonomuraea ATCC 39727 "mutant type" RNA polymerase.2009
- Author(s)
  Tala, A., G. Wang,. M. Zemanova., S. Okamoto., K. Ochi., P. Alifano.
- Journal Title
  
  J. Bacteriol. 191
  
  Pages: 805-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic over production.2009
- Author(s)
  Wang, G., T. Inaoka, S. Okamoto, K. Ochi.
- Journal Title
  
  Antimicrob. Agents Chem other 53
  
  Pages: 1019-1026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Biosynthesis of actinorhodin and related antibiotics : Discovery of alternative routes for quinine formation encoded in the Streptomyces coelicolor gene cluster.2009
- Author(s)
  Okamoto, S., T. Taguchi, K. Ochi, K. Ichinose.
- Journal Title
  
  Chem. Biol. 16
  
  Pages: 226-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Bacterial alarmone, guanosine 5'-diphosphate 3'-diphosphate (ppGpp), binds the b' subunit of plastid-encoded plastid RNA polymerase in chloroplasts.2009
- Author(s)
  Sato, M., K. Takahashi, Y. Ochiai, T. Hosaka, K. Ochi, K. Nabeta.
- Journal Title
  
  ChemBioChem. 10
  
  Pages: 1227-1233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Novel gene regulation mediated by overproduction of secondary metabolite neotrehalosadiamine in Bacillus subtilis2009
- Author(s)
  T Inaoka, T Satomura, Y Fujita, K Ochi
- Journal Title
  
  FEMS Microbiol Lett 291
  
  Pages: 151-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations2008
- Author(s)
  G Wang, T Hosaka, K Ochi
- Journal Title
  
  Applied and Environmental Microbiology 74
  
  Pages: 2834-2840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Activation of Dormant Bacterial Genes by Nonomuraea sp. Strain ATCC 39727 Mutant-Type RNA Polymerase2008
- Author(s)
  A Tala, G Wang, M Zemanova, S Okamoto, K Ochi, P Alifano
- Journal Title
  
  Journal of Bacteriology 191
  
  Pages: 805-814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] A Novel Insertion Mutation in Streptomyces coelicolor Ribosomal S12 protein results in paromomycin Resistance and Antibiotic Overproduction2008
- Author(s)
  G Wang, T Inaoka, S Okamoto, K Ochi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 53
  
  Pages: 1019-1026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug-resistance mutations.2008
- Author(s)
  Wang, G., T. Hosaka, K. Ochi.
- Journal Title
  
  Appl. Environ. Microbiol. 74
  
  Pages: 2834-2840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Actinoperylone, a novel peryle nequinone-type shunt product, from a deletion mutant of the actVA-OFR5 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2).2008
- Author(s)
  Taguchi, T., S. Okamoto., T. Itoh., Y. Ebizuka., K. Ochi, K. Ichinose.
- Journal Title
  
  Tetrahedron Letters. 49
  
  Pages: 1208-1211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Isolation and characterization of soprulation-initiation mutation in Bacillus subtilis prfB gene.2007
- Author(s)
  Asai, K., T. Inaoka., H, Nanamiya., Y. Sadaie., K. Ochi., F. Kawamura.
- Journal Title
  
  Biosci. Biotechnol. Biochem. 71
  
  Pages: 397-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp.2007
- Author(s)
  Kawai, K., G. Wang., S. Okamoto., K. Ochi.
- Journal Title
  
  FEMS Microbiol. Lett. 274
  
  Pages: 311-315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction.2007
- Author(s)
  Nishimura, K., T. Hosaka., S. Tokuyama., S. Okamoto., K. Ochi.
- Journal Title
  
  J. Bacteriol. 189
  
  Pages: 3876-3883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants.2007
- Author(s)
  Nishimura, K., S. K. Johansen., T. Inaoka., T. Hosaka., S. Tokyuyama., T. Tahara., S. Okamoto., F. Kawamura., S. Douthwaite., K. Ochi.
- Journal Title
  
  J. Bacteriol. 189
  
  Pages: 6068-6073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Glucose up take pathway-specific regulation of synhtesis of neotrehalosadiamine, an novel autoinducer produced in Bacillus subtilis.2007
- Author(s)
  Inaoka, T., K. Ochi.
- Journal Title
  
  J. Bacteriol. 189
  
  Pages: 65-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] A fail-safe system for the ribosome under zinc-limiting conditions in Bacillus subtilis.2007
- Author(s)
  Natori, Y., H. Nanamiya., G. Akanuma., S. Kosono., T. Kudo., K. Ochi., F. Kawamura.
- Journal Title
  
  Mol. Microbiol. 63
  
  Pages: 294-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria.2007
- Author(s)
  Okamoto, S., A. Tamaru., C. Nakajima., K. Nishimura., Y. Tanaka., S. Tokuyama., Y. Suzuki., K. Ochi.
- Journal Title
  
  Mol. Microbiol. 63
  
  Pages: 1096-1106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibitoic-overproducing Streptomyces coel icolor ribosomal rpsL mutant.2006
- Author(s)
  Hosaka, T., J. Xu., K. Ochi.
- Journal Title
  
  Mol. Microbiol. 61
  
  Pages: 833-897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Physiological analysis of tehstringent response elicited in an extreme thermophilic bacterium, The rmus thermophilus.2006
- Author(s)
  Kasai, K., T. Nishizawa., K. Takahashi., T. Hosaka., H. Aoki., K. Ochi.
- Journal Title
  
  J. Bacteriol. 188
  
  Pages: 7111-7122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Improvement of α-amylase production by modulating the ribosomal component S12 protein in Bacillus subtilis 168.2006
- Author(s)
  Kurosawa, K., T. Hosaka, N. Tamehiro, T. Inaoka, K. Ochi.
- Journal Title
  
  Appl. Environ. Microbiol. 72
  
  Pages: 71-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] EshA accentuates ppGpp accumulation and is conditionally required for antibiotic producton in Streptomyces coelicolor A3(2).2006
- Author(s)
  Saito, N., J. Xu., T. Hosaka., S. Okamoto., H. Aoki., M. J. Bibb., K. Ochi.
- Journal Title
  
  J. Bacteriol. 188
  
  Pages: 4952-4961
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Journal Article] Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.
- Author(s)
  Taguchi, T., S. Okamoto., A. Lezhava., A. Li., K. Ochi., Y. Ebizaka., K. Ichinose.
- Journal Title
  
  FEMS Microbiol. Lett. 269
  
  Pages: 234-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17380058
[Presentation] ハイグロマイシンBの活用による紅麹菌の潜在的二次代謝活性化2014
- Author(s)
  水上智也, 越智幸三, 保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  東京・明治大学生田キャンパス
- Year and Date
  2014-03-29
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リンコマイシンによるStreptomyces 属放線菌の潜在的抗生物質生産能の活性化2014
- Author(s)
  今井優, 佐藤誠造, 田中幸徳, 越智幸三保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  日本農芸化学会
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces 属放線菌の潜在的抗生物質生産能力を引き出すエリスロマイシン耐性変異の特定と機能解析2013
- Author(s)
  今井　優綾木啓太　渡邉　健　　越智幸三　　保坂　毅
- Organizer
  日本農芸化学会2013年度大会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 亜致死濃度のリンコマイシンが放線菌の二次代謝に及ぼす影響2013
- Author(s)
  今井優, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  メルパルク広島
- Year and Date
  2013-09-05
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 休眠遺伝子とその活用2013
- Author(s)
  越智幸三
- Organizer
  韓国農芸化学会
- Place of Presentation
  韓国プサン
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 休眠遺伝子覚醒技術の構築とその活用2013
- Author(s)
  越智幸三
- Organizer
  バイオインダストリー協会「育種の最前線」
- Place of Presentation
  メルパルク広島
- Year and Date
  2013-12-07
- Invited
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces 属放線菌の潜在的抗生物質生産能力を引き出すエリスロマイシン耐性変異の特定と機能解析2013
- Author(s)
  今井優, 綾木啓太, 渡邊健, 越智幸三, 保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Activation of silent genes in bacteria2013
- Author(s)
  越智幸三
- Organizer
  米国化学会
- Place of Presentation
  アメリカ・ニューオリンズ
- Year and Date
  2013-04-08
- Invited
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] rRNA(rrn)オペロン改変枯草菌を被検菌とした新規RNA ポリメラーゼ攻撃性抗生物質探索法の開発2013
- Author(s)
  田中幸徳, 河村富士夫, 越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  日本放線菌学会
- Year and Date
  2013-09-05
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 抗生物質生産能力が向上したStreptomyces coelicolor A3(2) のrpsLK88E 変異株におけるシグマ因子遺伝子の発現プロファイル解析2013
- Author(s)
  藤澤知弘, 岩川千紘, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  メルパルク広島
- Year and Date
  2013-09-06
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces 属放線菌の潜在的抗生物質生産能力を引き出すエリスロマイシン耐性変異の同定と特性解析2012
- Author(s)
  今井優, 渡邊健, 綾木啓太, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Year and Date
  2012-09-07
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces coelicolor A3(2)の抗生物質高生産rpsLK88E 変異株の定常期高翻訳活性を担う因子群の包括的解析2012
- Author(s)
  岩川千紘, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 放線菌の抗生物質高生産rpsL(S12)変異株の定常期に存在する翻訳活性化因子の解析2012
- Author(s)
  岩川千紘, 今井優, 渡邊健, 越智幸三,保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 放線菌の抗生物質高生産rpsL(S12)変異株のて定常期に存在する翻訳活性化因子の解析2012
- Author(s)
  岩川千紘, 今井優, 渡邉健, 越智幸三, 保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 抗生物質抗生産をひきおこす「リンコマイシン耐性変異」の同定と解析2012
- Author(s)
  王　国君　　田中幸徳　　保坂　毅　　越智　幸三
- Organizer
  2012年度日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リファンピシン耐性付与による放線菌の抗生物質生産性の増加と二次代謝の活性化に関する研究2012
- Author(s)
  田中幸徳, 越智幸三
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces coelicolorA3(2) の抗生物質高生産rpsLK88E変異株の定常期高翻訳活性を担う因子群の包括的解析2012
- Author(s)
  岩川千紘　　越智幸三　　保坂　毅
- Organizer
  2012年度日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 抗生物質抗生産をひきおこす「リンコマイシン耐性変異」の同定と解析2012
- Author(s)
  王国君田中幸徳保坂毅越智幸三
- Organizer
  日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リボゾーム工学により育種したサイクロデキストラン合成酸素生産菌の解析2012
- Author(s)
  田中幸徳, 舟根和美, 保坂毅, 稲岡隆史, 越智幸三
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リボゾーム攻撃性薬剤を利用した紅麹菌の潜在的色素生産力の劇的活性化2012
- Author(s)
  水上智也, 越智幸三, 保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リファンピシン耐性（rpoB）変異の導入による各種放線菌の”休眠遺伝子”活性化と二次代謝産物の分析2012
- Author(s)
  田中　幸徳　　廣瀬由鷹　　釘宮理恵　　笠原　堅　　越智幸三
- Organizer
  2012年度日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リファンピシン耐性(rpoB)変異の導入による各種放線菌の"休眠遺伝子"活性化と二次代謝産物の分析2012
- Author(s)
  田中幸徳, 廣瀬由鷹, 釘宮理恵, 笠原堅,越智幸三
- Organizer
  日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 海藻アカモクの食物繊維の季節変化2011
- Author(s)
  村上香、橋本哲明、角川幸治、越智幸三
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 放線菌の潜在的な二次代謝産物生産能の顕在化に及ぼすエリスロマイシン耐性付与の効果2011
- Author(s)
  今井優、藤原達也、千菊夫、越智幸三、保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 薬剤耐性変異の活用による抗生物質非生産放線菌の潜在能力開発2011
- Author(s)
  吉田龍右、田川遼、千菊夫、越智幸三、保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 生かさず殺さず-生物の潜在能力を探る-2011
- Author(s)
  越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  学校法人北里研究所(東京都)
- Year and Date
  2011-02-18
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces lividansの潜在的な抗菌物質生産力の顕在化に及ぼすエリストロマイシン耐性変異の効果2011
- Author(s)
  今井優, 藤原達也, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces sp.631689 の抗生物質高生産ゲンタミシン耐性変異株におけるリボゾームの特性解析2011
- Author(s)
  保坂毅, 藤原達也, 今井優, 越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces sp.631689の抗生物質高生産ゲンタミシン耐性変異株におけるリボゾームの特性解析2011
- Author(s)
  保坂毅, 藤原達也, 今井優, 越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces lividans の潜在的な抗生物質生産力の顕在化に及ぼすエリストロマイシン耐性変異の効果2011
- Author(s)
  今井優, 藤原達也, 越智幸三, 保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] ゲンタミシン耐性変異による放線菌の抗生物質生産活性化機構の解明2011
- Author(s)
  藤原達也、千菊夫、越智幸三、保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] S.avermitilis SUKAにおけるリファンピシン耐性変異が異種微生物由来の二次代謝産物生産に与える影響2011
- Author(s)
  小松護、三浦俊輔、越智幸三、池田治生
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都市)
- Year and Date
  2011-03-27
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Waking up bacterial sleeping genes- a new insight into secondary metabolism2010
- Author(s)
  Kozo Ochi
- Organizer
  Society for general Microbiology
- Place of Presentation
  University of Nottingham Jubilee Campus
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Waking Up Bacterial Sleeping Genes : a New Method to Elicit Bacterial Capabilities2010
- Author(s)
  Kozo Ochi
- Organizer
  Genetics of Industrial Microorganisms
- Place of Presentation
  Melbourne Convention, Exhibition Centre
- Year and Date
  2010-06-29
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 薬剤耐性付与による抗菌物質非生産放線菌の潜在能力活性化2010
- Author(s)
  吉田龍右、田川遼、岩川千紘、渡辺健、千菊夫、越智幸三、保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 様々な放線菌から分離したエリスロマイシン耐性変異株の特性解析2010
- Author(s)
  今井優、藤原達也、田中幸徳、千菊夫、越智幸三、保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 放線菌Streptomyces coelicolor A3(2)の二次代謝に及ぼす希土類元素の影響2010
- Author(s)
  田中幸徳、保坂毅、越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces avermitilisにおけるreLAの機能解析2010
- Author(s)
  小松護、越智幸三、池田治生
- Organizer
  日本放線菌学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] ストレプトマイシン弱耐性変異rsmG導入によるStreptomyces属の二次代謝能の変化2008
- Author(s)
  田中幸徳、岡本晋、小松譲、徳山真治、池田治生、越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  フルーツパーク富士屋ホテル(山梨県山梨市)
- Data Source
  KAKENHI-PROJECT-17380058
[Presentation] Actinorhodin 生合成におけるActVA-5, ActVA-6 の機能解析2008
- Author(s)
  田口貴章、岡本晋、越智幸三、市瀬浩志
- Organizer
  日本放線菌学会
- Place of Presentation
  フルーツパーク富士屋ホテル(山梨県山梨市)
- Data Source
  KAKENHI-PROJECT-17380058
[Presentation] Streptromyces coelicolor変異株における染色体環状化の解析2008
- Author(s)
  西川友也、荒川賢治、王国君、越智幸三、木梨陽康
- Organizer
  日本放線菌学会
- Place of Presentation
  フルーツパーク富士屋ホテル(山梨県山梨市)
- Data Source
  KAKENHI-PROJECT-17380058
[Presentation] 希土類元素「スカンジウム」による放線菌二次代謝の活性化2007
- Author(s)
  Kozo Ochi, et. al.
- Organizer
  2007年度日本放線菌学会大会
- Place of Presentation
  しまなみ交流館(テアトロシェルネ)・広島県尾道市
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-17380058
[Presentation] 亜致死濃度のリンコマイシンが放線菌の二次代謝に及ぼす影響
- Author(s)
  今井優　越智幸三　保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] リンコマイシンによるStreptomyces属放線菌の潜在的抗生物質生産能の活性化
- Author(s)
  今井優　佐藤誠造　田中幸徳　越智幸三　保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  東京・明治大学生田キャンパス
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] ｒRNA（ｒｒｎ）オペロン改変枯草菌を被検菌とした新規RNAポリメラーゼ攻撃性抗生物質探索法の開発
- Author(s)
  田中幸徳　河村富士夫　越智幸三
- Organizer
  日本放線菌学会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] 抗生物質生産能力が向上したStreptomyces coelicolor A3(2)のrpsLK88E変異株におけるシグマ因子遺伝子の発現プロファイル解析
- Author(s)
  藤澤知弘　岩川千紘　越智幸三　保坂毅
- Organizer
  日本放線菌学会
- Place of Presentation
  メルパルク広島
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Streptomyces 属放線菌の潜在的抗生物質生産能力を引き出すエリスロマイシン耐性変異の同定と特性解析
- Author(s)
  今井　優　　渡邉　健　　綾木啓太　　越智幸三　　保坂　毅
- Organizer
  2012年度日本放線菌学会大会
- Place of Presentation
  府中市府中の森芸術劇場
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] ハイグロマイシンBの活用による紅麹菌の潜在的二次代謝活性化
- Author(s)
  水上智也　越智幸三　保坂毅
- Organizer
  日本農芸化学会
- Place of Presentation
  東京・明治大学生田キャンパス
- Data Source
  KAKENHI-PROJECT-22380055
[Presentation] Acivation of silent genes in bacteria
- Author(s)
  越智幸三
- Organizer
  米国化学会
- Place of Presentation
  ニューオリンズ
- Invited
- Data Source
  KAKENHI-PROJECT-22380055

1. HOSAKA Takeshi

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# of Collaborated Products: 2 results
2. 庄村康人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 樋口芳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OCHI Kozo 越智 幸三

越智 幸三 オチ コウゾウ

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Development of the technology to activate actinomycete silent genesPrincipal Investigator

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Activation of dormant ability by modulating RNA polymerase and global clarification of transcription mechanismPrincipal Investigator

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[Book] 微生物の「休眠遺伝子」を活性化し抗生物質などを作り出す技術を開発、ブレインテクノニュース2007

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[Book] From microbial differentiation to ribosome engineering. Biosci. Biotechnol. Biochem.2007

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[Book] リボゾーム工学による微生物からの有用物質発見、月刊バイオインダストリー2007年10月号2007

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[Book] 微生物の二次代謝に生理的意義はあるのか? 抗生物質生産の新たな意味を探る、化学と生物2007

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[Book] 蛋白質 核酸 酵素2005

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[Journal Article] The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size2014

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[Journal Article] Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements2014

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[Journal Article] New strategies for drug discovery : activation of silent or weakly expressed microbial gene clusters2013

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[Journal Article] Chromosomal circularization of the model Streptomyces species, Streptomyces coelicolor A(3).2013

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[Journal Article] rRNA (rrn)operon-engineered Bacillus subtilis as a feasible test organism for antibiotic discovery2013

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[Journal Article] New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters2013

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[Journal Article] rRNA(rrn)Operon-Engineered Bacillus subtilis as a Feasible Test Organism for Antibiotic Discovery2013

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[Journal Article] Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes2013

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[Journal Article] Structure and biosynthesis of scabichelin a novel tris-hydroxamate siderophore produced by the plant pathogen Streptomyces scabies 87.222013

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[Journal Article] Chromosomal circularization of the model Streptomyces species2013

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OCHI Kozo 越智幸三

越智幸三オチコウゾウ

[Book] 蛋白質核酸酵素2005