HIDA Naoko 肥田直子

Researcher Number	70360112
Affiliation (based on the past Project Information) *help	2015: 慶應義塾大学, 医学部, 共同研究員 2013 – 2014: 慶應義塾大学, 医学部, 特任助教 2012 – 2013: 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 研究員 2012: 慶應義塾大学, 医学部, 研究員 2011: (独)国立成育医療研究センター, 生殖・細胞医療研究部, 共同研究員 … More 2009 – 2010: National Research Institute for Child Health and Development, 生殖・細胞医療研究部, 共同研究員 2008: National Research Institute for Child Health and Development, 生殖・細胞医療研究部, 共同研究員 2007 – 2008: 慶應義塾大学, 医学部, 助教 2005 – 2007: 国立成育医療センター(研究所), 生殖医療研究部, 共同研究員 2003 – 2004: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Thoracic surgery / Biomedical engineering/Biological material science
Keywords	Principal Investigator バイオリソース / ヒト幹細胞 / 心筋分化 / 再生医療 / 虚血性心疾患 / 虚血性心疾 / 再生医学 / 移植・再生医療 / 循環器 / 免疫寛容 … More / 羊膜 / ヒト間葉系細胞 / 細胞リソース / プロファイリング / 共培養 / 間葉系細胞 / 間葉系幹細胞 / 細胞プロファイリング / 細胞移植 / 遺伝子解析 / ES細胞 / バイオテクノロジー / 発生・分化 / 細胞・組織 / 心筋 / 細胞ラベリング / 生体吸収性ポリマー / 骨・軟骨 / 神経 / 分化誘導 / 骨髄間葉系幹細胞 … More Except Principal Investigator 細胞移植 / 心不全 / 幹細胞 / 間葉系幹細胞 / ヒト幹細胞 / 重症心不全 / 循環器・高血圧 / 再生医学 / 移植・再生医療 / 内視鏡 / 低侵襲 / 間葉系 / 疾患モデル動物 / 幹細胞移植 / 疾患モデル / 再生医療 / 免疫寛容 / 心疾患 / 大動物モデル / トランスレーショナルリサーチ / 細胞移植医療 / Arrhythmia / 心筋誘導 / arrhythmia / gene / human / stem cell / Cell sheet Less

Identification of Cardiomyogenic Factor and Improved Efficiency of Cardiomyogenesis in Human Mesenchymal Stem Cells(MSCs)- Participation of new immune cells -Principal Investigator
- Principal Investigator
  
  HIDA NAOKO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Keio University
  National Research Institute for Child Health and Development
Treatment for severe heart failure using human plancenta derived mesenchymal cells and differentiation inducing molecule to myocardiocytes
- Principal Investigator
  
  OKAMOTO KAZUMA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Keio University
Regenerative medicine for heart failure in large animal models
- Principal Investigator
  
  TOYODA Masashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Optimization and standardization of cultivation for human mesenchymal stem cells derived from differential tissuesPrincipal Investigator
- Principal Investigator
  
  HIDA Naoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development
Management of proarrhythmias according to the cardiac stem cell therapy
- Principal Investigator
  
  MIYOSHI Syunichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Keio University
虚血性心疾患/心筋症に対するヒト胎児付属物を用いた拍動心筋細胞移植戦略Principal Investigator
- Principal Investigator
  
  肥田直子
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development
高率に心筋へと分化するヒト間葉系幹細胞の探索と細胞移植後の病理病態学Principal Investigator
- Principal Investigator
  
  肥田直子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development
「幹細胞工学→再生医療」におけるナノバイオ・トレースシステムの創製Principal Investigator
- Principal Investigator
  
  肥田直子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Keio University

All 2015 2014 2011 2010 2008 2007 2004 Other

All Journal Article Presentation

[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015
- Author(s)
  Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
- Journal Title
  
  Biol Reprod
  
  Volume: 93巻 Issue: 2 Pages: 1-9
- DOI
  10.1095/biolreprod.114.127126
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10685, KAKENHI-PROJECT-15K15610, KAKENHI-PROJECT-25462574, KAKENHI-PROJECT-25463226, KAKENHI-PROJECT-25670181, KAKENHI-PROJECT-26861340
[Journal Article] Multidisciplinary approach to the treatment of cardiac AA amyloidosis and aortic stenosis due to Castleman's disease: A hybrid therapy withtocilizumab and aortic valve replacement.2014
- Author(s)
  Shirakawa K, Egashira T, Ieda M, Kawaguchi S, Okamoto K, Kudo M, Yokoyama K,Tsuruta H, Murata M, Mikami S, Anzai A, Hayashida K, Kohno T, Maekawa Y, Sano M, Yozu R, Fukuda K.
- Journal Title
  
  Int J Cardiol
  
  Volume: 173(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592047
[Journal Article] Treatment of human mesenchymal stem cells withangiotensin receptor blocker improved efficiency of cardiomyogenic trans differentiation and improved cardiac function via angiogenesis.2011
- Author(s)
  Numasawa Y, Kimura T, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H, Segawa K, Ogawa S, Umezawa A
- Journal Title
  
  Stem Cells
  
  Volume: 29(9) Pages: 1405-14
- Data Source
  KAKENHI-PROJECT-22659076
[Journal Article] Pretreatment of human mesenchymal stemcells with pioglitazone improved efficiency of cardiomyogenictransdifferentiation and cardiac function.2011
- Author(s)
  Shinmura D, Togashi I, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H,Segawa K, Tsukada Y, Ogawa S, Umezawa A
- Journal Title
  
  Stem Cells
  
  Volume: 29(2) Pages: 357-66
- Data Source
  KAKENHI-PROJECT-22659076
[Journal Article] Pretreatment of Human Mesenchymal Stem Cells with Pioglitazone Improved Efficiency of Cardiomyogenic Transdifferentiation and Improved Cardiac Function2010
- Author(s)
  Shinmura D., Togashi I., Miyoshi S., Nishiyama N., Hida N., Tsuji H., Tsuruta H., Nakamizo H., Segawa K., Tsukada Y., Ogawa S., Umezawa A.
- Journal Title
  
  Stem Cells.
  
  Volume: 29 Pages: 357-366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659076
[Journal Article] Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes2010
- Author(s)
  Tsuji H, Miyoshi S, Ikegami Y, Hida N, Asada H, Togashi I, Suzuki J, Satake M, Nakamizo H, Tanaka M, Mori T, Segawa K, Nishiyama N, Inoue J, Makino H, Miyado K, Ogawa S, Yoshimura Y, Umezawa A.
- Journal Title
  
  Circ Res.
  
  Volume: 28;106(10) Pages: 1613-1623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659076
[Journal Article] Serum-independent cardiomyogenic transdifferentiation in human endome trium-derived mesenchymal cells.2010
- Author(s)
  Ikegami Y, Miyoshi S, Nishiyama N, Hida N, Okamoto K, Miyado K, Segawa K, Ogawa S, Umezawa A.
- Journal Title
  
  Artif Organs.
  
  Volume: Apr;34(4) Pages: 280-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659076
[Journal Article] Novel cardiac precursor -like cells from human menstrual blood -derived mesenchymal cells.2008
- Author(s)
  Hida N, Miyoshi S
- Journal Title
  
  Stem Cells 26・7
  
  Pages: 1695-1704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300175
[Journal Article] Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells2008
- Author(s)
  N. Hida, S Miyoshi
- Journal Title
  
  Stem Cells 26(7)
  
  Pages: 1695-1704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300175
[Journal Article] 心筋再生と不整脈心筋細胞シート移植片のホストとの電気的同期現象2008
- Author(s)
  三好俊一郎, 肥田直子
- Journal Title
  
  心電図 28(4)(招待)
  
  Pages: 309-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300175
[Journal Article] The significant cardiomyogenic potential of human umbilical cord blood-derived mesenchymal stem cells in vitro2007
- Author(s)
  S Miyoshi, N. Hida
- Journal Title
  
  Stem Cells. 25(8)
  
  Pages: 2017-2024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300175
[Journal Article] 'Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells2007
- Author(s)
  S Miyoshi, N. Hida
- Journal Title
  
  Exp Cell Res. 313(12)
  
  Pages: 2550-2562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300175
[Journal Article] ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor.2004
- Author(s)
  Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, Yoshida K, Nakada M, Ohuchi E, Okada
- Journal Title
  
  Am J Pathol. 165・5
  
  Pages: 1743-1753
- Data Source
  KAKENHI-PROJECT-15659089
[Journal Article] The Significant Cardiomyogenic Potential of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Vitro
- Author(s)
  Nishiyama N, Miyoshi S, Hida N, et al.
- Journal Title
  
  STEM CELLS (in press)
- Data Source
  KAKENHI-PROJECT-17659107
[Presentation] 心嚢内視鏡を用いた心筋への低侵襲ヒト幹細胞デリバリーシステムの開発2011
- Author(s)
  岡本一真、三好俊一郎、木村雄弘、肥田直子、四津良平
- Organizer
  第15回日本心筋・血管新生療法研究会
- Place of Presentation
  ホテルブエナビスタ (長野県）
- Data Source
  KAKENHI-PROJECT-23592047
[Presentation] Pretreatement with IL10 significantly improved efficiency of immunological tolerance and rate of survival of cardiomyocyte transdifferentiated from human amniotic membrane-derived mesenchymal stem cell in vivo2010
- Author(s)
  Hiroko Tsuji, Shunichiro Miyoshi, Naoko Hida, Nobuhiro Nishiyama, Ikuko Togashi Hikaru Nakamizo, Yukinori Ikegai, Kaoru Segawa, Yasunori Yoshimura, Satoshi Ogawa, Akihiro Umezawa
- Organizer
  第74回日本循環器学会
- Place of Presentation
  京都国際会議場
- Year and Date
  2010-03-06
- Data Source
  KAKENHI-PROJECT-19659093
[Presentation] ピオグリダゾン活性化骨髄間葉系幹細胞移植がイヌ心筋梗塞モデルで心機能を改善する2010
- Author(s)
  高橋辰郎、古梶清和、三好俊一郎、岡本一真、石田治、木村雄弘、宗形昌儒、村木浩司、稲川浩平、肥田直子、西山信大、新村大輔、梅澤明弘、四津良平
- Organizer
  第63回日本胸部外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-22659076

1. UMEZAWA Akihiro (70213486)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. MIYOSHI Syunichiro (10296577)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. TOYODA Masashi (50392486)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 秦順一 (90051614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. GOJO Satoshi (90316745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ITAKURA Yoko (30582746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAMI Daisuke (80415588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. INOUE Mayu (40596920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKAMOTO KAZUMA (10338064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. KIMURA Takehiro (20449002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. MARUYAMA Tetsuo (10209702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. OHTA Kuniaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 長島隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIDA Naoko 肥田 直子

Research Projects

Research Products

Co-Researchers

Identification of Cardiomyogenic Factor and Improved Efficiency of Cardiomyogenesis in Human Mesenchymal Stem Cells(MSCs)- Participation of new immune cells -Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Treatment for severe heart failure using human plancenta derived mesenchymal cells and differentiation inducing molecule to myocardiocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative medicine for heart failure in large animal models

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Optimization and standardization of cultivation for human mesenchymal stem cells derived from differential tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Management of proarrhythmias according to the cardiac stem cell therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

虚血性心疾患/心筋症に対するヒト胎児付属物を用いた拍動心筋細胞移植戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高率に心筋へと分化するヒト間葉系幹細胞の探索と細胞移植後の病理病態学Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

「幹細胞工学→再生医療」におけるナノバイオ・トレースシステムの創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multidisciplinary approach to the treatment of cardiac AA amyloidosis and aortic stenosis due to Castleman's disease: A hybrid therapy withtocilizumab and aortic valve replacement.2014

Author(s)

Journal Title

Data Source

[Journal Article] Treatment of human mesenchymal stem cells withangiotensin receptor blocker improved efficiency of cardiomyogenic trans differentiation and improved cardiac function via angiogenesis.2011

Author(s)

Journal Title

Data Source

[Journal Article] Pretreatment of human mesenchymal stemcells with pioglitazone improved efficiency of cardiomyogenictransdifferentiation and cardiac function.2011

Author(s)

Journal Title

Data Source

[Journal Article] Pretreatment of Human Mesenchymal Stem Cells with Pioglitazone Improved Efficiency of Cardiomyogenic Transdifferentiation and Improved Cardiac Function2010

Author(s)

Journal Title

Data Source

[Journal Article] Xenografted human amniotic membrane-derived mesenchymal stem cells are immunologically tolerated and transdifferentiated into cardiomyocytes2010

Author(s)

Journal Title

Data Source

[Journal Article] Serum-independent cardiomyogenic transdifferentiation in human endome trium-derived mesenchymal cells.2010

Author(s)

Journal Title

HIDA Naoko 肥田直子