Ago Hideo 吾郷日出夫

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吾郷日出夫アゴウヒデオ

AGO Hideo 吾郷日出夫

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Researcher Number	70360477
Other IDs	https://orcid.org/0000-0002-9040-488X
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 放射光科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2015 – 2017: 国立研究開発法人理化学研究所, 放射光科学総合研究センター, 専任研究員 2013: 独立行政法人理化学研究所, 放射光科学総合研究センター, 専任研究員 2008 – 2012: The Institute of Physical and Chemical Research, 宮野構造生物物理研究室, 専任研究員 2006: RIKEN Spring-8 Center Harima Institute, Structural Biophysics Laboratory, Senior Research Scientist, 構造生物物理, 主任研究員 2005 – 2006: 理化学研究所, 構造生物物理, 先任研究員
Review Section/Research Field	Principal Investigator Structural biochemistry Except Principal Investigator General medical chemistry
Keywords	Principal Investigator X線結晶構造解析 / 膜タンパク質 / 結晶化 / 膜蛋白質 / 蛋白質 / 放射光 / 脂質メディエータ / 放射光構造生物 / lipid mediator / membrane protein … More / Protein crystallography / 脂質 / 炎症 / ロイコトリエン / 界面活性剤 / Ｘ線結晶構造解析 / モノクローナル抗体 / 酵素活性 / 蛋白質改変 / X線結晶構造 / 膜蛋白 / プロスタグランジンE2 / アラキドン酸カスケード … More Except Principal Investigator metal-binding / apotosis / ceramide / sphingomyelinase / 阻害剤 / 酵素 / X線結晶構造解析 / 脂質ラフト / アポトーシス / 膜結合 / 金属結合 / スフィンゴミエリナーゼ / セラミド / スフィンゴミエリン / リン脂質 Less

Structure basis of lipophilic ligand binding of membrane protein involving in lipid mediator biosynthesisPrincipal Investigator
- Principal Investigator
  
  Ago Hideo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research
Crystal structure determination of microsomal prostaglandin E2 synthase 1 with the open active site.Principal Investigator
- Principal Investigator
  
  AGO Hideo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
X-ray crystallographic analysis of microsomal prostaglandin E2synthase1Principal Investigator
- Principal Investigator
  
  AGO Hideo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Structural basis of the neutral sphingomyelinase to understand the lipid raft
- Principal Investigator
  
  TSUGE Hideaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokushima Bunri University

All 2017 2013 2012 2011 2010 2009 2008 2006

All Journal Article Presentation

[Journal Article] Development of a dose-limiting data collection strategy for serial synchrotron rotation crystallography2017
- Author(s)
  Hasegawa Kazuya、Yamashita Keitaro、Murai Tomohiro、Nuemket Nipawan、Hirata Kunio、Ueno Go、Ago Hideo、Nakatsu Toru、Kumasaka Takashi、Yamamoto Masaki
- Journal Title
  
  Journal of Synchrotron Radiation
  
  Volume: 24 Issue: 1 Pages: 29-41
- DOI
  10.1107/s1600577516016362
- NAID
  120005947170
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04343
[Journal Article] Protein microcrystallography using synchrotron radiation2017
- Author(s)
  Yamamoto Masaki、Hirata Kunio、Yamashita Keitaro、Hasegawa Kazuya、Ueno Go、Ago Hideo、Kumasaka Takashi
- Journal Title
  
  IUCrJ
  
  Volume: 4 Issue: 5 Pages: 529-539
- DOI
  10.1107/s2052252517008193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04343
[Journal Article] A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid2013
- Author(s)
  Ago, H. Okimoto, N. Kanaoka, Y. Morimoto, G. Ukita, Y. Saino, H. Taiji, M. Miyano, M.
- Journal Title
  
  journal of biochemistry
  
  Volume: in press Issue: 5 Pages: 421-429
- DOI
  10.1093/jb/mvt007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570153
[Journal Article] The Catalytic Architecture of Leukotriene C4 Synthase with Two Arginine Residues2011
- Author(s)
  Saino, Hiromichi Ukita, Yoko Ago, Hideo Irikura, Daisuke Nisawa, Atsushi Ueno, Go Yamamoto, Masaki Kanaoka, Yoshihide Lam, Bing K. Austen, K. Frank Miyano, Masashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 16392-16401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570153
[Journal Article] Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-β-D-selenomaltoside.2011
- Author(s)
  Saino Hiromichi, Ago Hideo, Ukita Yoko, Miyano Masashi.
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun.
  
  Volume: 67 Pages: 1666-1673
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570153
[Journal Article] The catalytic architecture of Leukotriene C4 synthase with two arginine residues2011
- Author(s)
  Saino H., Ago H., et al.
- Journal Title
  
  J.Biol.Chem. (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20370042
[Journal Article] システインロイコトリエン研究の新知見2010
- Author(s)
  吾郷日出夫、宮野雅司
- Journal Title
  
  日本結晶学会誌 52
  
  Pages: 69-75
- NAID
  10026107914
- Data Source
  KAKENHI-PROJECT-20370042
[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006
- Author(s)
  Ago H., 等
- Journal Title
  
  J Biol Chem. 281・23
  
  Pages: 16157-16167
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590256
[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006
- Author(s)
  Ago H., et al.
- Journal Title
  
  J Biol Chem. 281・23
  
  Pages: 16157-16167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590256
[Journal Article] Structural basis of the Sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006
- Author(s)
  Ago H., 等
- Journal Title
  
  J Biol chem. 281・23
  
  Pages: 16157-16167
- Data Source
  KAKENHI-PROJECT-17590256
[Presentation] Fixed target serial crystallography at SACLA2017
- Author(s)
  Masaki Yamamoto, Hideo Ago, Kunio Hirata, Keitaro Yamashita, Go Ueno, Minoru Kubo, Seiki Baba, Kazuya Hasegawa, Takashi Kumasaka, Atsuhiro Shimada, Kyoko Shinzawa-Itoh, Tomitake Tsukihara, Shinya Yoshikawa, Michihiro Suga, Fusamichi Akita, Jian-Ren Shen
- Organizer
  ACA2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04343
[Presentation] X-ray protein crystallography free from radiation damage at SACLA2012
- Author(s)
  Ago, H.
- Organizer
  The Sagamore XVII
- Place of Presentation
  Date, Hokkaido
- Year and Date
  2012-07-19
- Data Source
  KAKENHI-PROJECT-23570153
[Presentation] Synchrotron radiation structural biology of proteins functioning at biological membrane2010
- Author(s)
  吾郷日出夫
- Organizer
  第27回内藤コンファレンス生体膜ダイナミクスと脂質生物学[I]
- Place of Presentation
  札幌市
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-20370042
[Presentation] Synchrotron radiation structural biology of proteins functioning at biological memebrane2010
- Author(s)
  吾郷日出夫
- Organizer
  第27回内藤コンファレンス生体膜ダイナミクスと脂質生物学[I]
- Place of Presentation
  札幌市
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-20370042
[Presentation] プロスタグランジンE_2合成酵素1の大量発現精製と結晶化2009
- Author(s)
  吾郷日出夫
- Organizer
  日本結晶学会平成21年度年会
- Place of Presentation
  西宮市
- Data Source
  KAKENHI-PROJECT-20370042
[Presentation] プロスタグランジンE_2合成酵素1の大量発現精製と結晶化2009
- Author(s)
  吾郷日出夫
- Organizer
  日本結晶学会年会
- Place of Presentation
  関西学院大学上ヶ原キャンパス(兵庫県西宮市)
- Data Source
  KAKENHI-PROJECT-20370042
[Presentation] ロイコトリエンC_4合成酵素の変異体による酵素触媒機構の解析2008
- Author(s)
  吾郷, 日出夫
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20370042

1. SAINO Hiromichi (40525549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. TSUGE Hideaki (40299342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KATUNUMA Nobuhiko (50035375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAKURAI Jun (80029800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MIYANO Masashi (80332287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ago Hideo 吾郷 日出夫

吾郷 日出夫 アゴウ ヒデオ

AGO Hideo 吾郷 日出夫

Research Projects

Research Products

Co-Researchers

Structure basis of lipophilic ligand binding of membrane protein involving in lipid mediator biosynthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crystal structure determination of microsomal prostaglandin E2 synthase 1 with the open active site.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

X-ray crystallographic analysis of microsomal prostaglandin E2synthase1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis of the neutral sphingomyelinase to understand the lipid raft

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of a dose-limiting data collection strategy for serial synchrotron rotation crystallography2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Protein microcrystallography using synchrotron radiation2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Catalytic Architecture of Leukotriene C4 Synthase with Two Arginine Residues2011

Author(s)

Journal Title

Data Source

[Journal Article] Seleno-detergent MAD phasing of leukotriene C4 synthase in complex with dodecyl-β-D-selenomaltoside.2011

Author(s)

Journal Title

Data Source

[Journal Article] The catalytic architecture of Leukotriene C4 synthase with two arginine residues2011

Author(s)

Journal Title

Data Source

[Journal Article] システインロイコトリエン研究の新知見2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Structural basis of the Sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from bacillus cereus.2006

Author(s)

Journal Title

Data Source

[Presentation] Fixed target serial crystallography at SACLA2017

Author(s)

Organizer

Ago Hideo 吾郷日出夫

吾郷日出夫アゴウヒデオ

AGO Hideo 吾郷日出夫