Takatsu Hiroyuki 高津宏之

… Alternative Names

TAKATSU Hiroyuki 高津宏之

高津宏之タカツヒロユキ

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Researcher Number	70360576
Other IDs
Affiliation (Current)	2025: 京都大学, 薬学研究科, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2022: 京都大学, 薬学研究科, 研究員 2013 – 2014: 京都大学, 薬学研究科(研究院), 研究員 2004 – 2006: 独立行政法人理化学研究所, 免疫系構築研究チーム, 研究員 2003: 独立行政法人理化学研究所, 粘膜免疫系再構築研究チーム, 研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 48040:Medical biochemistry-related / Biological pharmacy / Pathological medical chemistry
Keywords	Principal Investigator フリッパーゼ / P4-ATPase / リン脂質 / ATP11C / ATP8B1 / 内皮細胞 / 毛細血管 / ホスファチジルコリン / 知的障害 / ATP8B2 … More / 生体膜 / 細胞生物学 / ダウンレギュレーション / PS露出 / エンドサイトーシス / PKC / uropod / phosphatidylserine / 極性細胞 / ホスファチジルセリン / 胆汁うっ滞症 / PFIC / Fc受容体 / nepmucin / CD300lg / CD300 / 免疫グロブリン / IgM / IgA / Fc受容体(FcR) Less

Elucidation of the relationship between phospholipid flippase ATP8B2 mutation and intellectual disabilitiesPrincipal Investigator
- Principal Investigator
  
  TAKATSU Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Regulatory mechanism of phospholipids flippase ATP11C in non-apoptotic cellsPrincipal Investigator
- Principal Investigator
  
  Takatsu Hiroyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyoto University
Inadequate flip-flop of phosphatidylcholine is responsible for PFIC (progressive familial intrahepatic cholestasis).Principal Investigator
- Principal Investigator
  
  TAKATSU Hiroyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
毛細血管内皮細胞特異的に発現する新規のIg受容体様タンパク質の同定と機能解析Principal Investigator
- Principal Investigator
  
  高津宏之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
M細胞における新規IgA受容体の同定と機能解析Principal Investigator
- Principal Investigator
  
  高津宏之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research

All 2021 2019 2018 2017 2014 2006 Other

All Journal Article Presentation

[Journal Article] The interaction of ATP11C-b with ezrin contributes to its polarized localization2021
- Author(s)
  Inoue Hiroki、Takatsu Hiroyuki、Hamamoto Asuka、Takayama Masahiro、Nakabuchi Riki、Muranaka Yumeka、Yagi Tsukasa、Nakayama Kazuhisa、Shin Hye-Won
- Journal Title
  
  Journal of Cell Science
  
  Volume: 134 Issue: 20
- DOI
  10.1242/jcs.258523
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H04904, KAKENHI-PROJECT-19H00980, KAKENHI-PROJECT-20K07325, KAKENHI-PROJECT-20H03209
[Journal Article] The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane2019
- Author(s)
  Takayama Masahiro、Takatsu Hiroyuki、Hamamoto Asuka、Inoue Hiroki、Naito Tomoki、Nakayama Kazuhisa、Shin Hye-Won
- Journal Title
  
  Journal of Cell Science
  
  Volume: 132 Issue: 17
- DOI
  10.1242/jcs.231720
- NAID
  120006731146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00980, KAKENHI-PROJECT-17H03655, KAKENHI-PROJECT-17K08270
[Journal Article] Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.2019
- Author(s)
  Roland, B.P., Naito, T., Best, J.T., Arinaiz-Yepez, C., Takatsu, H., Yu, R.J., Shin, H.-W., and Graham, T.R.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 6 Pages: 1794-1806
- DOI
  10.1074/jbc.ra118.005876
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03655, KAKENHI-PROJECT-17K08270
[Journal Article] Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)2019
- Author(s)
  Shin, H.-W. and Takatsu, H.
- Journal Title
  
  FASEB Journal
  
  Volume: 33 Issue: 3 Pages: 3087-3096
- DOI
  10.1096/fj.201801873r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03655, KAKENHI-PROJECT-17K08270
[Journal Article] ATPase reaction cycle of P4‐ATPases affects their transport from the endoplasmic reticulum2019
- Author(s)
  Tone Takuya、Nakayama Kazuhisa、Takatsu Hiroyuki、Shin Hye‐Won
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 3 Pages: 412-423
- DOI
  10.1002/1873-3468.13629
- NAID
  120006800731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H00980, KAKENHI-PROJECT-17H03655, KAKENHI-PROJECT-20K07325
[Journal Article] Phospholipid-flipping activity of P4-ATPase drives membrane curvature.2018
- Author(s)
  Takada, N., Naito, T., Inoue, T., Nakayama, K., Takatsu, H., and *Shin, H.-W.
- Journal Title
  
  The EMBO Journal
  
  Volume: in press Issue: 9
- DOI
  10.15252/embj.201797705
- NAID
  120007144982
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H00764, KAKENHI-PROJECT-15H04370, KAKENHI-PROJECT-16J05381, KAKENHI-PROJECT-17K08270, KAKENHI-PROJECT-17H03655
[Journal Article] Phospholipid flippase ATP11C is endocytosed and downregulated following Ca<sup>2+</sup>-mediated protein kinase C activation.2017
- Author(s)
  Takatsu H, Takayama M, Naito T, Takada N, Tsumagari K, Ishihama Y, Nakayama K, Shin HW.
- Journal Title
  
  Nat Commun.
  
  Volume: Nov 10;8(1) Issue: 1 Pages: 1423-1423
- DOI
  10.1038/s41467-017-01338-1
- NAID
  120006365525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08270, KAKENHI-PUBLICLY-16H00764, KAKENHI-PROJECT-15H04370, KAKENHI-PROJECT-16J05381, KAKENHI-PROJECT-17H03655
[Journal Article] Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane2014
- Author(s)
  Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K. and Shin, H.W.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 289 Issue: 48 Pages: 33543-33556
- DOI
  10.1074/jbc.m114.593012
- NAID
  120005690224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22000013, KAKENHI-PROJECT-24659134, KAKENHI-PROJECT-24790278, KAKENHI-PUBLICLY-25113514, KAKENHI-PROJECT-25670165, KAKENHI-PROJECT-26460065
[Journal Article] CD300 Antigen Like Family Member G : A Novel Ig Receptor Like Protein Exclusively Expressed on Capillary Endothelium.2006
- Author(s)
  Takatsu H. et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 348
  
  Pages: 183-191
- Data Source
  KAKENHI-PROJECT-17790335
[Presentation] P4-ATPaseによるグルコシルセラミドの輸送と生理的意義2019
- Author(s)
  高津宏之、内藤朋樹、Siddabasavegowda Bommegowda、有田誠、中山和久、申惠媛
- Organizer
  第９２回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K08270
[Presentation] リン脂質フリッパーゼATP11Cとezrinの相互作用2018
- Author(s)
  井上寛己、高津宏之、高山真裕、中山和久、申　惠媛
- Organizer
  第９１回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08270
[Presentation] リン脂質フリッパーゼATP11CのC末バリアントの特性2018
- Author(s)
  高津宏之、高山真裕、井上寛己、中山和久、申　惠媛
- Organizer
  第９１回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08270
[Presentation] Functional differences between splicing variants of phospholipids flippase ATP11C2017
- Author(s)
  Masahiro Takayama, Hiroyuki Takatsu , Kazuhisa Nakayama and Hye-Won Shin
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08270
[Presentation] 非アポトーシス細胞におけるリン脂質フリッパーゼATP11Cの制御機構2017
- Author(s)
  高津宏之、高山真裕、中山和久、申　惠媛
- Organizer
  2017年度　生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08270
[Presentation] ホスファチジルコリンのフリップ‧-フロップの相関性の破綻とPFIC（進行性家族性肝内胆汁うっ滞症）2014
- Author(s)
  高津宏之、田中雅久、中山和久、申　惠媛
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25670165
[Presentation] 脂質二重層の非対称性を調節するP4-ATPaseのリサイクリング経路における機能解析
- Author(s)
  小野夏生、高津宏之、中山和久、申　惠媛
- Organizer
  第86回　日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25670165
[Presentation] ATP8B1(FIC1, familial intrahepatic cholestasis 1)はフォスファチジルコリンのフリッパーゼである
- Author(s)
  高津宏之、中山和久、申　惠媛
- Organizer
  第86回　日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25670165

1. SUZUKI Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 申惠媛

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
3. 中山和久

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 長田重一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 瀬川勝盛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takatsu Hiroyuki 高津 宏之

TAKATSU Hiroyuki 高津 宏之

高津 宏之 タカツ ヒロユキ

Research Projects

Research Products

Co-Researchers

Elucidation of the relationship between phospholipid flippase ATP8B2 mutation and intellectual disabilitiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of phospholipids flippase ATP11C in non-apoptotic cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inadequate flip-flop of phosphatidylcholine is responsible for PFIC (progressive familial intrahepatic cholestasis).Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

毛細血管内皮細胞特異的に発現する新規のIg受容体様タンパク質の同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

M細胞における新規IgA受容体の同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The interaction of ATP11C-b with ezrin contributes to its polarized localization2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ATPase reaction cycle of P4‐ATPases affects their transport from the endoplasmic reticulum2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Phospholipid-flipping activity of P4-ATPase drives membrane curvature.2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Phospholipid flippase ATP11C is endocytosed and downregulated following Ca<sup>2+</sup>-mediated protein kinase C activation.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane2014

Author(s)

Journal Title

DOI

NAID

Takatsu Hiroyuki 高津宏之

TAKATSU Hiroyuki 高津宏之

高津宏之タカツヒロユキ