Tanigaki Kenji 谷垣健二

… Alternative Names

TANIGAKI Kenji 谷垣健二

谷垣健二タニガキケンジ

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Researcher Number	70362473
Other IDs
Affiliation (Current)	2025: 滋賀県立総合病院(臨床研究センター), ゲノム疫学研究部門, 専門研究員
Affiliation (based on the past Project Information) *help	2023: 滋賀県立総合病院(臨床研究センター), ゲノム疫学研究部門, 専門研究員 2023: 滋賀県立総合病院(臨床研究センター), 神経病態研究部門, 専門研究員 2018 – 2022: 滋賀県立総合病院(研究所), 神経病態研究部門, 専門研究員 2015 – 2017: 滋賀県立成人病センター(研究所), 神経病態研究部門, 専門研究員 2013 – 2016: 滋賀県立成人病センター(研究所), その他部局等, その他 … More 2014: 滋賀県立成人病センター(研究所), その他部局等, 専門研究員 2013: 滋賀県立成人病センター(研究所), その他部局等, 研究員 2013: 滋賀県立成人病センター, 研究員 2012: 滋賀県立成人病センター研究所, 専門研究員 2011 – 2012: 滋賀県立成人病センター(研究所), 神経病態研究部門, 専門研究員 2009: Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員 2008 – 2009: Research Institute, Shiga Medical Center, 遺伝子研究部門, 専門研究員 2005 – 2006: 滋賀県立成人病センター(研究所), 遺伝子研究部門, 主任研究員 Less
Review Section/Research Field	Principal Investigator General medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related / Pathological medical chemistry Except Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery / Basic Section 56040:Obstetrics and gynecology-related / Pathological medical chemistry
Keywords	Principal Investigator schizophrenia / 22q11 deletion syndrome / copy number variation / 神経発生 / Notch / RBP-J / QTL / epistasis / Dgcr8 / 22q11欠損症候群 … More / 統合失調症 / conditional knockout / 大脳皮質 / consomic mice / QTL analysis / NgR1 / Comt / PPI / NMDAR / miRNA / 脳神経疾患 / lymphoblastoid cell / EBV / lymphoblastoid cell line / Schizophrenia / SDF1 / ケモカイン / Cxcl12 / Cxcr4 / 22q11 / レンチウイルス / 動物モデル / Cre / 神経回路網 / 転写因子 / instrumental learning / striatum / neuron / active avoidance / 高次生命医学 / 発生医学 / conditional knockout mice … More Except Principal Investigator 抗癌剤 / DDS / ファージディスプレイ / 血液脳関門 / 分子標的薬 / 悪性神経膠腫 / ナノエマルジョン / ゲルダナマイシン / MRI / がん幹細胞 / VEGFA / VEGFA抗体 / 腫瘍微小環境 / 抗VEGFA抗体 / 自然免疫マウスモデル / 卵巣癌 / CD276 / B7H3 / エピゲノム / anti-cancer agent / molecular targeted / glioblastoma / m-RNA / lipid nanoparticle / ペプチドプローブ / pituitary adenoma / VEGF受容体阻害薬 / NOTCH阻害薬 / 下垂体卒中 / 下垂体腺腫 / DAPT / HES / NOTCH / PROP1 / クッシング病 / 難治性下垂体腺腫 / OSI-930 / VEGF / Notch / Prop1 / 悪性神経厚種 / ファージディスプレイ法 / 分子標的抗癌剤 / drug delivery system / 分子標的 / 磁気共鳴画像 / 抗がん剤 / 癌幹細胞 / エンドゾーム / 神経幹細胞 / 骨髄間質細胞 / 胚性幹細胞 / 移植治療 / 再生医療 / 脳梗塞 / 脳血管障害学 / Mastermind / 統合失調症 / Notchシグナル Less

Exploring epistasis responsible for the pathogenesis of schizophreniaPrincipal Investigator
- Principal Investigator
  
  谷垣健二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Shiga General Hospital Clinical Research Center
難治性卵巣癌に対する、抗VEGF抗体とB7H3を標的とした併用療法の開発
- Principal Investigator
  
  村上隆介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Development of molecular-targeted anticancer agents for epigenetic changes in malignant glioma
- Principal Investigator
  
  椎野顯彦
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
Elucidation of the missing heritability of schizophreniaPrincipal Investigator
- Principal Investigator
  
  Tanigaki Kenji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Research Institute, Shiga Medical Center
Analysis of NOTCH and PROP1 as new therapeutic targets in high-risk pituitary adenomas
- Principal Investigator
  
  Hojo Masato
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Research Institute, Shiga Medical Center
Development of Innovative Anticancer Drug Delivery System for Malignant Glioma
- Principal Investigator
  
  Shiino Akihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Shiga University of Medical Science
Development of molecular targeted anticancer drug using peptide probe for glioblastoma multiforme
- Principal Investigator
  
  Shiino Akihiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Shiga University of Medical Science
Involvement of Cxcl12/Cxcr4 signaling deficits in schizophreniaPrincipal Investigator
- Principal Investigator
  
  Tanigaki Kenji
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Research Institute, Shiga Medical Center
Transplantation of iPS cell-derived neuronal stem cells into ischemic brain
- Principal Investigator
  
  Takagi Yasushi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University
The neural circuits underlying the pathophysiologies of schizophreniaPrincipal Investigator
- Principal Investigator
  
  TANIGAKI Kenji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Research Institute, Shiga Medical Center
Involvement of a co-factor of Notch signaling, Mastermind, into Schizophrenia
- Principal Investigator
  
  KITAGAWA Motoo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Chiba University
The neural circuit for dopaminergic system regulation by Notch signalingPrincipal Investigator
- Principal Investigator
  
  TANIGAKI Kenji
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  滋賀県立成人病センター研究所
   Research Institute, Shiga Medical Center
The molecular mechanism of maturation defects of RBP-J-deficient neurons.Principal Investigator
- Principal Investigator
  
  TANIGAKI Kenji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Research Institute, Shiga Medical Center
神経機能におけるNotch/RBP-Jシグナルの役割の解析Principal Investigator
- Principal Investigator
  
  谷垣健二
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Research Institute, Shiga Medical Center

[Journal Article] Inhibition of VEGF receptors induces pituitary apoplexy: An experimental study in mice2023
- Author(s)
  Sugita Yoshito、Takada Shigeki、Tanigaki Kenji、Muraki Kazue、Uemura Munehiro、Hojo Masato、Miyamoto Susumu
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 3 Pages: e0279634-e0279634
- DOI
  10.1371/journal.pone.0279634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07319, KAKENHI-PROJECT-20K09360
[Journal Article] Contribution of PROP1 in the pathogenesis of Cushing’s disease: A preliminary study2023
- Author(s)
  Takebe Noriyoshi、Hojo Masato、Takada Shigeki、Sugita Yoshito、Tanigaki Kenji、Tanji Masahiro、Miyamoto Susumu
- Journal Title
  
  Interdisciplinary Neurosurgery
  
  Volume: 31 Pages: 101691-101694
- DOI
  10.1016/j.inat.2022.101691
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09360
[Journal Article] B7-H3 Suppresses Antitumor Immunity via the CCL2-CCR2-M2 Macrophage Axis and Contributes to Ovarian Cancer Progression2022
- Author(s)
  Miyamoto T, Murakami R, Hamanishi J, Tanigaki K, Hosoe Y, Mise N, Takamatsu S, Mise Y, Ukita M, Taki M, Yamanoi K, Horikawa N, Abiko K, Yamaguchi K, Baba T, Matsumura N, Mandai M.
- Journal Title
  
  Cancer Immunol Res .
  
  Volume: 10 Issue: 1 Pages: 56-69
- DOI
  10.1158/2326-6066.cir-21-0407
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09287, KAKENHI-PROJECT-20K18210, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-21J15178, KAKENHI-PROJECT-20K07319, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-20K21665, KAKENHI-PROJECT-20K16431
[Journal Article] Machine learning of brain structural biomarkers for Alzheimer's disease (AD) diagnosis, prediction of disease progression, and amyloid beta deposition in the Japanese population2021
- Author(s)
  Shiino Akihiko、Shirakashi Yoshitomo、Ishida Manabu、Tanigaki Kenji、Japanese Alzheimer's Disease Neuroimaging Initiative
- Journal Title
  
  Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
  
  Volume: 13 Issue: 1
- DOI
  10.1002/dad2.12246
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07319
[Journal Article] Machine Learning for Diagnosis of AD and Prediction of MCI Progression From Brain MRI Using Brain Anatomical Analysis Using Diffeomorphic Deformation.2021
- Author(s)
  Ali Haidar Syaifullah, Akihiko Shiino, Hitoshi Kitahara, Ryuta , Manabu Ishida, Kenji Tanigaki
- Journal Title
  
  Front Neurol
  
  Volume: 111 Pages: 576029-576029
- DOI
  10.3389/fneur.2020.576029
- NAID
  120006979531
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07319
[Journal Article] Tbx1, a gene encoded in 22q11.2 copy number variant, is a link between alterations in fimbria myelination and cognitive speed in mice2021
- Author(s)
  Hiramoto Takeshi、Sumiyoshi Akira、Yamauchi Takahira、Tanigaki Kenji、Shi Qian、Kang Gina、Ryoke Rie、Nonaka Hiroi、Enomoto Shingo、Izumi Takeshi、Bhat Manzoor A.、Kawashima Ryuta、Hiroi Noboru
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 未定 Issue: 2 Pages: 929-938
- DOI
  10.1038/s41380-021-01318-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08079, KAKENHI-PROJECT-20K07319
[Journal Article] Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ.2020
- Author(s)
  Mikael Marttinen, Catarina B Ferreira, Kaisa M A Paldanius, Mari Takalo, Teemu Natunen, Petra Makinen, Luukas Leppanen, Ville Leinonen, Kenji Tanigaki, Gina Kang, Noboru Hiroi, Hilkka Soininen, Kirsi Rilla, Annakaisa Haapasalo, Mikko Hiltunen
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 11 Pages: 2482-2482
- DOI
  10.3390/cells9112482
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07319
[Journal Article] Maternal approach behaviors toward neonatal calls are impaired by mother's experiences of raising pups with a risk gene variant for autism.2020
- Author(s)
  Risa Kato, Akihiro Machida, Kensaku Nomoto, Gina Kang, Takeshi Hiramoto, Kenji Tanigaki, Kazutaka Mogi, Noboru Hiroi, Takefumi Kikusui
- Journal Title
  
  Dev Psychobiol
  
  Volume: 63 Issue: 1 Pages: 108-113
- DOI
  10.1002/dev.22006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07319, KAKENHI-PUBLICLY-20H04932, KAKENHI-PROJECT-18H02356, KAKENHI-PROJECT-19K21822, KAKENHI-PROJECT-19K22373
[Journal Article] Thalamocortical Circuit Dysfunctions in Schizophrenia: Insights From 22q11.2 Deletion Syndrome.2020
- Author(s)
  Kenji Tanigaki
- Journal Title
  
  Biol Psychiatry Cogn Neurosci Neuroimaging
  
  Volume: 5 Issue: 9 Pages: 842-843
- DOI
  10.1016/j.bpsc.2020.07.003
- Data Source
  KAKENHI-PROJECT-20K07319
[Journal Article] Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis.2018
- Author(s)
  Boku S, Izumi T, Abe S, Takahashi T, Nishi A, Nomaru H, Naka Y, Kang G, Nagashima M, Hishimoto A, Enomoto S, Duran-Torres G, Tanigaki K, Zhang J, Ye K, Kato S, Männistö PT, Kobayashi K, Hiroi N.
- Journal Title
  
  Mol Psychiatry.
  
  Volume: 23 Issue: 4 Pages: 985-992
- DOI
  10.1038/mp.2017.158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-16K10183
[Journal Article] Regulation of striatal dopamine responsiveness by Notch/RBP-J signaling.2017
- Author(s)
  Toritsuka M, Kimoto S, Muraki K, Kitagawa M, Kishimoto T, Sawa A, Tanigaki K.
- Journal Title
  
  Transl Psychiatry.
  
  Volume: 7 Issue: 3 Pages: e1049-e1049
- DOI
  10.1038/tp.2017.21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-26460381, KAKENHI-PROJECT-16K08577
[Journal Article] Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM.2017
- Author(s)
  Shiino A, Chen YW, Tanigaki K, Yamada A, Vigers P, Watanabe T, Tooyama I, Akiguchi I.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 39818-39818
- DOI
  10.1038/srep39818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-16K18050
[Journal Article] Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery.2017
- Author(s)
  Nagura K, Takemoto Y, Moronaga S, Uchida Y, Shimono S, Shiino A, Tanigaki K, Amano T, Yoshino F, Noda Y, Koizumi S, Komatsu N, Kato T, Yamauchi J, Tamura R.
- Journal Title
  
  Chemistry.
  
  Volume: 23 Pages: 15713-15720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293074
[Journal Article] Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor.2016
- Author(s)
  Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, Fukuda M, Saiki M, Hojo M, Miyamoto S, Onishi N, Saya H, Inubushi T, Nozaki K, Tanigaki K.
- Journal Title
  
  PLoS One
  
  Volume: 16;11(2): Issue: 2 Pages: e0149826-e0149826
- DOI
  10.1371/journal.pone.0149826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10330
[Journal Article] Polymorphism within a Neuronal Activity-Dependent Enhancer of NgR1 Is Associated with Corpus Callosum Morphology in Humans2015
- Author(s)
  Isobe M, Tanigaki K, Muraki K, Miyata J, Takemura A, Sugihara G, Takahashi H, Aso T, Fukuyama H, Hazama M, Murai T
- Journal Title
  
  Mol Neuropsychiatry
  
  Volume: 1 Issue: 2 Pages: 105-115
- DOI
  10.1159/000430463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460381, KAKENHI-PROJECT-22220003, KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-15H01690
[Journal Article] Neuronal migration abnormalities and its possible implications for schizophrenia.2015
- Author(s)
  Kazue Muraki, Kenji Tanigaki
- Journal Title
  
  Front Neurosci.
  
  Volume: 9 Pages: 74-74
- DOI
  10.3389/fnins.2015.00074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670154, KAKENHI-PROJECT-26293074, KAKENHI-PROJECT-26460381
[Journal Article] Arsenic trioxide sensitizes glioblastoma to a myc inhibitor.2015
- Author(s)
  Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, Fukuda M, Saiki M, Hojo M, Miyamoto S, Onishi N, Saya H, Inubushi T, Nozaki K, Tanigaki.
- Journal Title
  
  Plos One
  
  Volume: 10 Issue: 6 Pages: e0128288-e0128288
- DOI
  10.1371/journal.pone.0128288
- NAID
  120005947136
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460381, KAKENHI-PROJECT-26293074
[Journal Article] 遺伝子研究と統合失調症2014
- Author(s)
  谷垣健二
- Journal Title
  
  精神科
  
  Volume: 25 Pages: 593-597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670154
[Journal Article] 遺伝子研究と統合失調症2014
- Author(s)
  谷垣健二
- Journal Title
  
  精神科
  
  Volume: 25 Pages: 593-597
- Data Source
  KAKENHI-PROJECT-26293074
[Journal Article] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11 deletion syndrome mouse model.2013
- Author(s)
  Toritsuka M, Kimoto S, Muraki K, Landek-Salgado MA, Yoshida A, Yamamoto N, Horiuchi Y, Hiyama H, Tajinda K, Keni N, Illingworth E, Iwamoto T, Kishimoto T, Sawa A, Tanigaki K.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Issue: 43 Pages: 17552-17557
- DOI
  10.1073/pnas.1312661110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592545, KAKENHI-PROJECT-24659143, KAKENHI-PROJECT-25460506, KAKENHI-PROJECT-25670154
[Journal Article] Notch signaling regulates nucleocyt oplasmic Olig2 translocation in rea ctive astrocytes differentiation of ter ischemic stroke2013
- Author(s)
  Marumo T, Takagi Y, Muraki K, Hashi moto N, Miyamoto S, Tanigaki K
- Journal Title
  
  Neurosci Res
  
  Volume: (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Kif14 mutation causes severe brain malformation and hypomyelination.2013
- Author(s)
  Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T.
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e53490-e53490
- DOI
  10.1371/journal.pone.0053490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790350, KAKENHI-PROJECT-24300126
[Journal Article] Notch signaling regulates nucleocytoplasmic Olig2 translocation in reactive astrocytes differentiation after ischemic stroke2013
- Author(s)
  Marumo T, Takagi Y, Muraki K, Hashimoto N, Miyamoto S, Tanigaki K.
- Journal Title
  
  Neurosci Res
  
  Volume: 75(3) Issue: 3 Pages: 204-9
- DOI
  10.1016/j.neures.2013.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790350, KAKENHI-PROJECT-24659143, KAKENHI-PROJECT-25293308
[Journal Article] Hear Res Localization of septin proteins in the mouse cochlea2012
- Author(s)
  Yoshida A, Yamamoto N, Kinoshita M, Hiroi N, Hiramoto T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito J.
- Journal Title
  
  Epub ahead of print
  
  Volume: 289 Issue: 1-2 Pages: 40-51
- DOI
  10.1016/j.heares.2012.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791595, KAKENHI-PROJECT-23229009, KAKENHI-PROJECT-23370084, KAKENHI-PROJECT-23790350, KAKENHI-PROJECT-24592545
[Journal Article] Alterations of social interaction through genetic and environmental manipulation of the 22q11.2 gene Sept5 in the mouse brain.2012
- Author(s)
  Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N.
- Journal Title
  
  Hum Mol Genet
  
  Volume: 21(15) Issue: 15 Pages: 3489-99
- DOI
  10.1093/hmg/dds180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Localization of septin proteins in the mouse cochlea2012
- Author(s)
  Yoshida A, Yamam oto N, Kinoshita M, Hiroi N, Hiramo to T, Kang G, Trimble WS, Tanigaki K, Nakagawa T, Ito
- Journal Title
  
  J. Hear Res
  
  Volume: 289 (1-2) Pages: 40-51
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome.2012
- Author(s)
  Kagemasa Kajiwara
- Journal Title
  
  Translational Psychiatry
  
  Volume: 2 Issue: 8 Pages: 1-16
- DOI
  10.1038/tp.2012.70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590666, KAKENHI-PROJECT-22592050, KAKENHI-PROJECT-23790350
[Journal Article] Selective overexpression of Comt in prefrontal cortex rescues schizo phrenia-like phenotypes in a mouse model of 22q11 deletion syndrome2012
- Author(s)
  Kimoto S, Muraki K, Toritsuka M, Mu gikura S, Ka j iwara K, Kishimoto T, Illingworth E, Tanigaki K
- Journal Title
  
  Transl Psychiatry
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Alterations of social interaction t hrough genetic and environmental ma nipulation of the 22q11.2 gene Sept 5 in the mouse brain2012
- Author(s)
  Harper KM, Hiramoto T, Tanigaki K, Kang G, Suzuki G, Trimble W, Hiroi N
- Journal Title
  
  Hum Mol Genet
  
  Volume: 21(15) Pages: 3489-99
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus2011
- Author(s)
  Ishifune C, et al
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 Issue: 5 Pages: 1309-20
- DOI
  10.1002/eji.201041159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09121, KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-21590536, KAKENHI-PROJECT-23790350
[Journal Article] Notch signaling regulates the d evelopment of a novel type of T hy1-expressing dendritic cell i n the thymus2011
- Author(s)
  Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagi to H, Yasutomo K
- Journal Title
  
  Eur J Immunol
  
  Volume: 41 (5) Pages: 1309-20
- Data Source
  KAKENHI-PROJECT-23790350
[Journal Article] Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.2009
- Author(s)
  Carlen M, Meletis K, Goritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabe-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisen J.
- Journal Title
  
  Nat Neurosci 12
  
  Pages: 259-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790244
[Journal Article] Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.2009
- Author(s)
  arlen M, Meletis K, Goritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabe-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisen J.
- Journal Title
  
  Nat Neurosci 12
  
  Pages: 259-67
- Data Source
  KAKENHI-PROJECT-20790244
[Journal Article] RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.2009
- Author(s)
  Fujimoto M, Takagi Y, Muraki K, Nozaki K, Yamamoto N, Tsuji M, Hashimoto N, Honjo T, Tanigaki K.
- Journal Title
  
  Dev Biol. 332
  
  Pages: 339-350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790244
[Journal Article] Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice.2009
- Author(s)
  Suzuki G, Harper KM, Hiramoto T, Sawamura T, Lee M, Kang G, Tanigaki K, Buell M, Geyer MA, Trimble WS, Agatsuma S, Hiroi N.
- Journal Title
  
  Hum Mol Genet 18
  
  Pages: 1652-60
- Data Source
  KAKENHI-PROJECT-20790244
[Journal Article] RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.2009
- Author(s)
  Fujimoto M, Takagi Y, Muraki K, Nozaki K, Yamamoto N, Tsuji M, Hashimoto N, Honjo T, Tanigaki K.
- Journal Title
  
  Dev Biol 332
  
  Pages: 339-50
- Data Source
  KAKENHI-PROJECT-20790244
[Journal Article] Regulation of lymphocyte development by Notch signaling2007
- Author(s)
  Kenji Tanigaki
- Journal Title
  
  Nature Immunology (In press)
- Data Source
  KAKENHI-PROJECT-17689014
[Presentation] Cxcr4シグナルと統合失調症の関与2023
- Author(s)
  谷垣健二
- Organizer
  第４６回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K06419
[Presentation] Neuropathological analysis of Notch4 knockout mice.2022
- Author(s)
  Kenji Tanigaki
- Organizer
  第４５回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K07319
[Presentation] Behavioral Analysis of Notch4 knockout mice2021
- Author(s)
  Kenji Tanigaki
- Organizer
  第44回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K07319
[Presentation] Cxcr4 ノックアウトマウスの行動学的解析2020
- Author(s)
  谷垣健二
- Organizer
  第43回日本神経科学会
- Data Source
  KAKENHI-PROJECT-20K07319
[Presentation] Preparation of Robust Metal-Free Magnetic Nanoemulsions Encapsulating Low-Molecular-Weight Nitroxide Radicals and Hydrophobic Drugs Directed Toward MRI-Visible Targeted Delivery System.2018
- Author(s)
  K. Nagura, Y. Takemoto, S. Moronaga, Y. Uchida, S. Shimono, A. Shiino, K. Tanigaki, T. Amano, F. Yoshino, Y. Noda, S. Koizumi, N. Komatsu, T. Kato, J. Yamauchi, R. Tamura
- Organizer
  27th International Liquid Crystal Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08942
[Presentation] Regulation of Striatal Dopamine Responsiveness by Notch/RBP-J Signaling2017
- Author(s)
  Kenji Tanigaki
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-26293074
[Presentation] Deficits in microRNA-mediated Cxcr4/Cxcl12 signaling in neurodevelopmental deficits in a 22q11-deletion syndrome mouse model.2015
- Author(s)
  Kenji Tanigaki
- Organizer
  第38回神経科学会
- Place of Presentation
  神戸
- Year and Date
  2015-07-30
- Invited
- Data Source
  KAKENHI-PROJECT-26293074
[Presentation] 22q11欠損症候群モデルマウスにおける介在神経細胞移動の異常2015
- Author(s)
  谷垣健二
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293074
[Presentation] Comt-mediated regulation of GABAergic system in a 22q11 deletion syndrome model mice.2014
- Author(s)
  谷垣健二
- Organizer
  日本神経化学会
- Place of Presentation
  奈良
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-25670154
[Presentation] Comt-mediated regulation of GABAergic system in a 22q11 deletion syndrome model mice.2014
- Author(s)
  谷垣健二
- Organizer
  日本神経化学会
- Place of Presentation
  奈良
- Year and Date
  2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293074
[Presentation] 統合失調症とCxcr4/Cxcl12 シグナルの関与2014
- Author(s)
  谷垣健二
- Organizer
  第9回統合失調症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25670154
[Presentation] Molecular mechanisms underlying schizophrenia-like phenotypes of 22q11 model mice2013
- Author(s)
  Kenji Tanigaki
- Organizer
  11th world congress of biological psychiatry
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-25670154
[Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice.2013
- Author(s)
  谷垣健二
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24659143
[Presentation] Behavioral analysis of neuron-specific RBP-J knockout mice2013
- Author(s)
  谷垣健二
- Organizer
  The Notch Meeting VII
- Place of Presentation
  ギリシャ共和国アテネ市
- Data Source
  KAKENHI-PROJECT-24659143
[Presentation] Behavioral Analysis of Neuron-specific RBP-J knockout mice.2013
- Author(s)
  谷垣健二
- Organizer
  Notch Meeting VII
- Place of Presentation
  ギリシャ共和国アテネ市
- Data Source
  KAKENHI-PROJECT-24659143
[Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice.2013
- Author(s)
  Kenji Tanigaki
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25670154
[Presentation] Neuropathological analysis of 22q deletion syndrome model mice2013
- Author(s)
  谷垣健二
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-24659143
[Presentation] RBP-J conditional knockoutマウスの行動学的解析2012
- Author(s)
  谷垣健二
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24659143
[Presentation] Rescue of behavioral abnormalitie s of 22g11.2 deletion syndrome mo del mice by prefrontal cortex-spe cific COMT overexpression2012
- Author(s)
  Kenji Tanigaki
- Organizer
  第35回神経科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] Behavioral Analysis of Neuron-specific RBP-J knockout mice2011
- Author(s)
  Kenji Tanigaki
- Organizer
  The Notch Meeting
- Place of Presentation
  Greece
- Year and Date
  2011-10-05
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] Behavioral Analysis of Neuron-specific RBP-J knockout mice.2011
- Author(s)
  Kenji Tanigaki
- Organizer
  Notch Meeting
- Place of Presentation
  Greece
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] Neuropathological analysis of 22q 11.2 deletion syndrome model mice2011
- Author(s)
  谷垣健二
- Organizer
  第34回神経科学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] Neuropathological analysis of 22q11.2 deletion syndrome model mice2011
- Author(s)
  Kenji Tanigaki
- Organizer
  The 32nd Naito Conferece on Biol ogical basis of mental functions and disorders
- Place of Presentation
  八ケ岳
- Year and Date
  2011-10-19
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] RBP-J promotes neuronal differentiation.2009
- Author(s)
  Tanigaki K.
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-20790244
[Presentation] RBP-J promotes neuronal differentiation.2009
- Author(s)
  Tanigaki K.
- Organizer
  The Notch Meeting
- Place of Presentation
  ギリシア
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-20790244
[Presentation] RBP-J promotes neuronal differentiation.2009
- Author(s)
  Tanigaki K.
- Organizer
  第32回日本神経科学会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-20790244
[Presentation] BP-Jの神経機能における役割の解析2008
- Author(s)
  谷垣健二
- Organizer
  第3回Notch研究会
- Place of Presentation
  国立遺伝学研究所
- Year and Date
  2008-07-17
- Data Source
  KAKENHI-PROJECT-20790244
[Presentation] RBP-Jの神経機能における役割の解析2008
- Author(s)
  谷垣健二
- Organizer
  第3回Notch研究会
- Place of Presentation
  国立遺伝学研究所
- Year and Date
  2008-07-17
- Data Source
  KAKENHI-PROJECT-20790244
[Presentation] RBP-J conditional knockout マウスの行動学的解析
- Author(s)
  谷垣　健二
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790350
[Presentation] RBP-J conditional knockout マウスの行動学的解析
- Author(s)
  谷垣健二
- Organizer
  第35回日本分子生物学会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24659143

1. Shiino Akihiko (50215935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. KITAGAWA Motoo (40262026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. HASHIMOTO Kenji (10189483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Takagi Yasushi (40312227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Hojo Masato (60372588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 高橋淳 (10270779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森實飛鳥 (10528730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 荒川芳輝 (20378649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Zhao Li (40636156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田村類 (60207256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 丹治正大 (50766657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 村上隆介 (40782363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. YAMAMOTO Norio

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. BABA Tsukasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. IZUMI Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 村木一枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 梶原景正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 万代昌紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tanigaki Kenji 谷垣 健二

TANIGAKI Kenji 谷垣 健二

谷垣 健二 タニガキ ケンジ

Research Projects

Research Products

Co-Researchers

Exploring epistasis responsible for the pathogenesis of schizophreniaPrincipal Investigator

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難治性卵巣癌に対する、抗VEGF抗体とB7H3を標的とした併用療法の開発

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Development of molecular-targeted anticancer agents for epigenetic changes in malignant glioma

Principal Investigator

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Elucidation of the missing heritability of schizophreniaPrincipal Investigator

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Analysis of NOTCH and PROP1 as new therapeutic targets in high-risk pituitary adenomas

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Development of Innovative Anticancer Drug Delivery System for Malignant Glioma

Principal Investigator

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Development of molecular targeted anticancer drug using peptide probe for glioblastoma multiforme

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Involvement of Cxcl12/Cxcr4 signaling deficits in schizophreniaPrincipal Investigator

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Transplantation of iPS cell-derived neuronal stem cells into ischemic brain

Principal Investigator

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The neural circuits underlying the pathophysiologies of schizophreniaPrincipal Investigator

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Involvement of a co-factor of Notch signaling, Mastermind, into Schizophrenia

Principal Investigator

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The neural circuit for dopaminergic system regulation by Notch signalingPrincipal Investigator

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The molecular mechanism of maturation defects of RBP-J-deficient neurons.Principal Investigator

Principal Investigator

Tanigaki Kenji 谷垣健二

TANIGAKI Kenji 谷垣健二

谷垣健二タニガキケンジ