Nagayama Satoshi 長山聡

… Alternative Names

Researcher Number	70362499
Other IDs
External Links
Affiliation (Current)	2019 : 公益財団法人がん研究会, 有明病院消化器外科, 医長
Affiliation (based on the past Project Information) *help	2015 – 2019 : 公益財団法人がん研究会, 有明病院消化器外科, 医長 2017 : 公益財団法人がん研究会, 有明病院消化器外科, 医長 2015 : 公益財団法人がん研究会, 有明病院消化器外科, 医長 2014 – 2015 : 公益財団法人がん研究会, 大腸外科, 医長 2013 : 公益財団法人がん研究会, その他部局等, その他 … More
Review Section/Research Field	Principal Investigator Digestive surgery / Tumor biology / Basic Section 50010:Tumor biology-related / Tumor biology Except Principal Investigator Digestive surgery / Tumor diagnostics / Complex Systems Disease Theory / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related / Experimental pathology
Keywords	Principal Investigator 大腸癌 / 浸潤 / 抗体療法 / FZD10 / 大腸癌肝転移 / 発癌 / WNT伝達系 / Wnt伝達系 / 癌幹細胞 / 遺伝子変異 / 化学療法 / 大腸癌発生 … More Except Principal Investigator … More

Elucidation of chemoresistance-resistant signal mechanism of colon cancer liver metastasisOngoing
- Principal Investigator
  
  足立淳
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
遺伝性疾患を用いた遺伝的背景による大腸がん制御機構の解明Ongoing
- Principal Investigator
  
  八尾良司
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
遺伝子変異情報に基づいた大腸癌に対する新規治療戦略の開発Principal InvestigatorOngoing
- Principal Investigator
  
  長山聡
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Discovery of drug resistant mechnism by kinome analysis using patient derived cultured cellsOngoing
- Principal Investigator
  
  朝長毅
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
大規模経時採取血漿バンクの網羅的タンパク質変動解析による大腸癌再発予測因子の解明Ongoing
- Principal Investigator
  
  植田幸嗣
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Japanese Foundation for Cancer Research
Early diagnosis of colon cancer metastasis by multifaceted proteome analysis of metastatic lesion tissue and exosome
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Biomarker discovery of colorectal cancer metastasis from cancer tissues and verification in plasma exosomes by targeted proteomics.
- Principal Investigator
  
  Shiromizu Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Discovery of druggable targets of colorectal cancers by genomic analysis with cancer stem-like cellsPrincipal Investigator
- Principal Investigator
  
  Nagayama Satoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
Establishment of quantitation method for proteome-based phospho-signaling pathway and its application for prediction of drug effect monitoring
- Principal Investigator
  
  Tomonaga Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor diagnostics
- Research Institution
  National Institutes of Biomedical Innovation, Health and Nutrition
Functinal analysis of a novel gene involved in the progression of colorectal cancersPrincipal Investigator
- Principal Investigator
  
  NAGAYAMA satoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Japanese Foundation for Cancer Research
A role of FZD10, a WNT receptor, in the colon carcinogenesis.Principal Investigator
- Principal Investigator
  
  NAGAYAMA Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
腫瘍血管新生と低酸素環境を標的としたテーラーメード癌治療法の創出
- Principal Investigator
  
  MORI Akira
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
癌肉腫における上皮間葉二相性組織形成の分子機構
- Principal Investigator
  
  TOGUCHIDA Junya
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
大腸癌肝転移巣に対するFZD10を標的分子とした新規抗体療法の開発Principal Investigator
- Principal Investigator
  
  長山聡
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University
Analysis of cytokine secretion in locally recurrent rectal cancer and host-immune enhancement by gene induction
- Principal Investigator
  
  ONODERA Hisashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyoto University

All 2017 2016 2015 2014 2013 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers2014
- Author(s)
  Ryo Takahashi, Satoshi Nagayama, Moritoshi Furu, Yoichiro Kajita, Tomohisa Kato, Seiya Imoto, Yoshiharu Sakai and Junya Toguchida
- Journal Title
  
  Cancer Medicine
  
  Volume : (in press)
- Data Source
  KAKENHI-PROJECT-23501276
[Journal Article] AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers2014
- Author(s)
  Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J.
- Journal Title
  
  Cancer Med
  
  Volume : なし Pages : 759-774
- DOI
  10.1002/cam4.237
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501276, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-25670643
[Journal Article] Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma2009
- Author(s)
  Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T
- Journal Title
  
  Oncogene 28
  
  Pages : 1110-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.2009
- Author(s)
  Nagayama S, et al.
- Journal Title
  
  Cancer Sci. 100
  
  Pages : 405-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors.2009
- Author(s)
  Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J
- Journal Title
  
  Cancer Sci 100
  
  Pages : 405-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors2009
- Author(s)
  Nagayama S
- Journal Title
  
  Cancer Science 100
  
  Pages : 405-412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10.2008
- Author(s)
  Chikako Fukukawa, Hirofumi Hanaoka, Satoshi Nagayama, Tatsuhiko Tsunoda, Junya Toguchida, Keigo Endo, Yusuke Nakamura, Toyomasa Katagiri
- Journal Title
  
  Cancer Sci 99
  
  Pages : 432-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591589
[Journal Article] The administration of naked plasmid DNA in to the liver induces antit umor innate immunity in amurine liver metastasis model.2007
- Author(s)
  Yonenaga Y, Mori A, Fujimoto A, Nagayama S, Tachibana T, Onodera H, Uemoto S
- Journal Title
  
  Journal of Gene Medicine 9
  
  Pages : 299-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591461
[Journal Article] Tumour plasticity and extravascular circulation in ECV304 human bladder carcinoma cells.2006
- Author(s)
  Fujimoto A, Onodera H, Mori A, Nagayama S, Yonenaga Y, Tachibana
- Journal Title
  
  Anticancer Research 26
  
  Pages : 59-69
- Data Source
  KAKENHI-PROJECT-18591461
[Journal Article] Tumour plasticity and extravascular circulation in ECV304 human bladder carcinoma cells2006
- Author(s)
  Fujimoto A, Onodera H, Mori A, Nagayama S, Yonenaga Y, Tachibana T
- Journal Title
  
  Anticancer Res. 26(1A)
  
  Pages : 59-69
- Data Source
  KAKENHI-PROJECT-17790912
[Journal Article] Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas, and regulated by a member of ets family transcription factor, ELF32006
- Author(s)
  Yoshiki Kohno, Takeshi Okamoto, Tatsuya Ishibe, Satoshi Nagayama, Yasuko Shima, Kohichi Nishijo, Kohtaro R.Shibata, Koichi Fukiage, Seiji Otsuka, Daisuke Ueshima, Nobuhito Araki, Norifumi Naka, Yasuaki Nakashima, Tomoki Aoyama, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages : 38941-38950
- Data Source
  KAKENHI-PROJECT-17790912
[Journal Article] Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas2005
- Author(s)
  Nagayama, S., et al.
- Journal Title
  
  Oncogene 24(15)
  
  Pages : 6201-6212
- Data Source
  KAKENHI-PROJECT-17659114
[Journal Article] Therapeutic potential of antibodies against FZD10, a cell-surface protein, for synovial sarcomas2005
- Author(s)
  Nagayama, S., et al.
- Journal Title
  
  Oncogene 24
  
  Pages : 6201-6212
- Data Source
  KAKENHI-PROJECT-17790912
[Presentation] 大腸癌切除組織と組織培養分泌エクソソームの網羅的プロテオーム比較分析による大腸癌リキッドバイオプシー診断法開発2017
- Author(s)
  村岡賢, 大西なおみ, 池田篤志, 須磨崎真, 長山聡, 植田幸嗣
- Organizer
  日本細胞外小胞学会2017年年会
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Proteome-wide profiling of viable tissue-derived extracellular vesicles for development of early diagnostic biomarkers for colorectal cancer2017
- Author(s)
  Muraoka, S., Nagayama, S., and Ueda, K.
- Organizer
  The International Society For Extracellular Vesicles 6th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0116
[Presentation] Targeted proteomic analysis for biomarker discovery of colorectal cancer metastasis from plasma EVs.2016
- Author(s)
  Takashi Shiromizu, Mimiko Ishida, Naomi Ohnishi, Risa Fujii, Koji Ueda, Satoshi Nagayama and Takeshi Tomonaga.
- Organizer
  5th Annual Meeting of the International Society for Extracellular Vesicles
- Place of Presentation
  ロッテルダム
- Year and Date
  2016-05-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 大腸がん同一症例の原発/転移組織の定量プロテオミクス解析による転移マーカー探索および血中エクソソームマーカーへの応用2015
- Author(s)
  白水崇、長山聡、朝長毅
- Organizer
  第35回日本分子腫瘍マーカー研究会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-07
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] Proteomic analysis for biomarker discovery in metastatic colorectal cancer tissues and plasma exosomes.2015
- Author(s)
  Takashi Shiromizu, Satoshi Nagayama, Takeshi Tomonaga
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 大腸癌臨床組織膜タンパク質および血中エクソソームのプロテオーム解析による転移マーカーの探索2015
- Author(s)
  白水崇、長山聡、朝長毅
- Organizer
  第2回日本細胞外小胞学会
- Place of Presentation
  広島
- Year and Date
  2015-08-26
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] Biomarker discovery of colorectal cancer metastasis from cancer tissues and verification in plasma exosomes by targeted proteomics.2015
- Author(s)
  Takashi Shiromizu, Satoshi Nagayama, Takeshi Tomonaga
- Organizer
  第13回日本プロテオーム学会
- Place of Presentation
  熊本
- Year and Date
  2015-07-23
- Data Source
  KAKENHI-PROJECT-15K06865
[Presentation] 細胞骨格関連タンパクC7059は細胞形態および細胞遊走を制御し、大著癌進展に関与する2014
- Author(s)
  長山聡
- Organizer
  日本外科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] アクチン骨格関連タンパクC7059 は細胞遊走能および浸潤仮足(invadopodia)形成を制御し,大腸癌進展に関与する2013
- Author(s)
  高橋亮、長山聡、布留守敏、梶田洋一郎、村上哲平、加藤滋、久森重夫、山田理大、大越香江、角田茂、田中英治、河田健二、小濱和貴、長谷川傑、岡部寛、戸口田淳也、坂井義治
- Organizer
  第113回日本外科学会
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] 細胞骨格関連タンパクC7059 は細胞形態,遊走能および浸潤仮足形成を制御し,大腸癌進展に関与する2013
- Author(s)
  高橋亮、長山聡、布留守敏、梶田洋一郎、大越香江、山田理大、河田健二、長谷川傑、戸口田淳也、坂井義浩
- Organizer
  第68回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-23501276
[Presentation] 細胞骨格関連タンパクC7059 は細胞遊走能を制御して大腸癌進展に関与する2013
- Author(s)
  長山聡、高橋亮、井元清哉、布留守敏、梶田洋一郎、片桐豊雅、中村祐輔、坂井義治、戸口田淳也
- Organizer
  第72回日本癌学会
- Place of Presentation
  (英語口演)
- Data Source
  KAKENHI-PROJECT-23501276

1. TOMONAGA Takeshi (80227644)

# of Collaborated Projects : 5results

# of Collaborated Products : 5results
2. TOGUCHIDA Junya (40273502)

# of Collaborated Projects : 3results

# of Collaborated Products : 8results
3. 片山量平 (60435542)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
4. 足立淳 (20437255)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
5. MORI Akira (60324646)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
6. SAKAI Yoshiharu (60273455)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
7. KUBO Hajime (50362520)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. ONODERA Hisashi (50240825)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. TSURUYAMA Tatsuaki (00303842)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. Shiromizu Takashi (00582678)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
11. ISHIHAMA Yasushi (30439244)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. MATSUBARA Hisahiro (20282486)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 波多野悦朗 (80359801)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 小川晃平 (10359789)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 米永吉邦 (10422974)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 西尾誠人 (00281593)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 藤田直也 (20280951)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 植田幸嗣 (10509110)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
19. 八尾良司 (80291095)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 野村大成 (90089871)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. KATO Tomohisa

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

Nagayama Satoshi 長山 聡

NAGAYAMA Satoshi 長山 聡

Research Projects

Research Products

Co-Researchers

Elucidation of chemoresistance-resistant signal mechanism of colon cancer liver metastasisOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝性疾患を用いた遺伝的背景による大腸がん制御機構の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝子変異情報に基づいた大腸癌に対する新規治療戦略の開発Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of drug resistant mechnism by kinome analysis using patient derived cultured cellsOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

大規模経時採取血漿バンクの網羅的タンパク質変動解析による大腸癌再発予測因子の解明Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Early diagnosis of colon cancer metastasis by multifaceted proteome analysis of metastatic lesion tissue and exosome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Biomarker discovery of colorectal cancer metastasis from cancer tissues and verification in plasma exosomes by targeted proteomics.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Discovery of druggable targets of colorectal cancers by genomic analysis with cancer stem-like cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of quantitation method for proteome-based phospho-signaling pathway and its application for prediction of drug effect monitoring

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functinal analysis of a novel gene involved in the progression of colorectal cancersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A role of FZD10, a WNT receptor, in the colon carcinogenesis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

腫瘍血管新生と低酸素環境を標的としたテーラーメード癌治療法の創出

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

癌肉腫における上皮間葉二相性組織形成の分子機構

Principal Investigator

Project Period (FY)

Nagayama Satoshi 長山聡

NAGAYAMA Satoshi 長山聡