Tsuchimoto Daisuke 土本大介

… Alternative Names

TSUCHIMOTO Daisuke 土本大介

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Researcher Number	70363348
Other IDs
External Links
Affiliation (Current)	2025: 九州大学, 生体防御医学研究所, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 九州大学, 生体防御医学研究所, 助教 2007 – 2014: Kyushu University, 生体防御医学研究所, 助教 2004 – 2006: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Biological Sciences / Experimental pathology Except Principal Investigator Risk sciences of radiation/Chemicals / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 細胞死 / イノシン / イノシン三リン酸 / ITPA / 脱分極 / てんかん / cell death / 酸化ストレス / p38MAPK / 細胞増殖抑制 … More / 2-OH-ATP / 神経変性 / 遺伝子改変マウス / 膜電位 / EIEE35 / 静止膜電位脱分極 / 発達性およびてんかん性脳症 / 発達性およびてんかん性脳症３５ / 脳症 / 静止膜電位 / マウスモデル / イノシン三リン酸分解酵素 / nuclear genome / mitochondrial genome / Huntington's disease / Parkinson's disease / neurodegeneration / 8-oxoguanine / oxidative stress / 損傷ヌクレオチド分解酵素 / 塩基除去修復 / 酸化DNA損傷 / 核ゲノム / ミトコンドリアゲノム / ハンチントン舞踏病 / パーキンソン病 / 8-オキソグアニン / 酸化ATP / cell growth suppression / inosine / 8-oxo-GTP / 発がん / 遊離ヌクレオチド損傷 / DNA酸化損傷 / 動物 … More Except Principal Investigator DNA修復 / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル / 化学物質 / 環境ストレス / アルツハイマー病 / ヌクレオチドプール / 放射線 / 活性酸素 / ８－オキソグアニン / ミクログリア / ８-オキソグアニン / アミロイドーシス / 神経新生 / 加齢 / 神経細胞死 / ミクログリオーシス / 神経炎症応答 / 8-オキソグアニン / 環境スレス / 自然突然変異 / 細胞増殖阻害 / 酸化的損傷 / 神経変性 / 細胞死 / バイスタンダー効果 / 突然変異 / RNA / DNA Less

イノシン三リン酸分解酵素欠損の分子病態解明Principal Investigator
- Principal Investigator
  
  土本大介
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyushu University
Elucidation of molecular pathogenesis of ITPA deficiency and development of its treatmentPrincipal Investigator
- Principal Investigator
  
  Tsuchimoto Daisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyushu University
Investigation of brain damage caused by reactive oxygen species and its defense mechanisms
- Principal Investigator
  
  Yusaku Nakabeppu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
ＡＴＰの酸化体によるシグナル伝達Principal Investigator
- Principal Investigator
  
  土本大介
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress
- Principal Investigator
  
  NAKABEPPU YUSAKU
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
ATPおよびGTPの酸化体による細胞内シグナル伝達機構の解明Principal Investigator
- Principal Investigator
  
  土本大介
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse modelsPrincipal Investigator
- Principal Investigator
  
  TSUCHIMOTO Daisuke
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Molecular pathological analysis of defects in DNA base excision repair system using gene modified micePrincipal Investigator
- Principal Investigator
  
  TSUCHIMOTO Daisuke
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University

[Journal Article] Neural stem cell?specific ITPA deficiency causes neural depolarization and epilepsy2020
- Author(s)
  Koga Yuichiro、Tsuchimoto Daisuke、Hayashi Yoshinori、Abolhassani Nona、Yoneshima Yasuto、Sakumi Kunihiko、Nakanishi Hiroshi、Toyokuni Shinya、Nakabeppu Yusaku
- Journal Title
  
  JCI Insight
  
  Volume: 5 Issue: 22
- DOI
  10.1172/jci.insight.140229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09896, KAKENHI-PROJECT-18K06960, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-16H06276
[Journal Article] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes2019
- Author(s)
  Haruyama, N., Sakumi, K., Katogi, A., Tsuchimoto, D., De Luca, G., Bignami, M., and Nakabeppu, Y.
- Journal Title
  
  Progress in Neurobiology
  
  Volume: 180 Pages: 101613-101613
- DOI
  10.1016/j.pneurobio.2019.04.002
- NAID
  120006839234
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.2018
- Author(s)
  Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI.
- Journal Title
  
  Annals of Neurology
  
  Volume: 84 Issue: 2 Pages: 208-224
- DOI
  10.1002/ana.25279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11477, KAKENHI-PROJECT-18K19650, KAKENHI-PROJECT-17K19663, KAKENHI-PROJECT-17H01391
[Journal Article] 2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway2017
- Author(s)
  Asada Shinji、Ohta Eiko、Akimoto Yoriko、Abolhassani Nona、Tsuchimoto Daisuke、Nakabeppu Yusaku
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6528-6528
- DOI
  10.1038/s41598-017-06636-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01391
[Journal Article] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.2014
- Author(s)
  Nomaru, H., Sakumi, K., Katogi, A., Ohnishi, Y.N., Kajitani, K., Tsuchimoto, D., Nestler, E.J., and Nakabeppu, Y.
- Journal Title
  
  Glia
  
  Volume: N/A Issue: 8 Pages: 1284-1298
- DOI
  10.1002/glia.22680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-24591735, KAKENHI-PROJECT-25870494
[Journal Article] MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death2014
- Author(s)
  Oka S, Leon J, Tsuchimoto D, Sakumi K, Nakabeppu Y
- Journal Title
  
  Oncogenesis
  
  Volume: 3 Issue: 10 Pages: 1-10
- DOI
  10.1038/oncsis.2014.35
- NAID
  120005703608
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-25461281
[Journal Article] Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation2014
- Author(s)
  Stavnezer J, Linehan EK, Thompson MR, Habboub G, Ucher AJ, Kadungure T, Tsuchimoto D, Nakabeppu Y
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 111 Issue: 25 Pages: 9217-9222
- DOI
  10.1073/pnas.1405590111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells2014
- Author(s)
  Guikema JE, Linehan EK, Esa N, Tsuchimoto D, Nakabeppu Y, Woodland RT, Schrader CE
- Journal Title
  
  J Immunol
  
  Volume: 193 Pages: 931-939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012
- Author(s)
  Sheng, Z., et. al.
- Journal Title
  
  The Journal of clinical investigation
  
  Volume: 122 Issue: 12 Pages: 4344-4361
- DOI
  10.1172/jci65053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004
[Journal Article] Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.2011
- Author(s)
  Guikema, J.E., R.M.Gerstein, E.K.Linehan, E.K.Cloherty, E.Evan-Browning, D.Tsuchimoto, Y.Nakabeppu, C.E.Schrader.
- Journal Title
  
  J Immunol
  
  Volume: 186 Pages: 1943-1950
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues.2011
- Author(s)
  Iwama, E., D.Tsuchimoto, T.Iyama, K.Sakumi, A.Nakagawara, K.Takayama, Y.Nakanishi, Y.Nakabeppu.
- Journal Title
  
  J Mol Neurosci.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] DNA glycosylase encoded by MUTYH functions as a molecular switch for programmed cell death under oxidative stress to suppress tumorigenesis2011
- Author(s)
  Oka S, Nakabeppu Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Issue: 4 Pages: 677-682
- DOI
  10.1111/j.1349-7006.2011.01869.x
- NAID
  10029291748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-22501014
[Journal Article] ニトロソ化ストレスによるイノシン三リン酸の生成と細胞応答2011
- Author(s)
  作見邦彦, 土本大介, 中別府雄作
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 175-180
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] A comprehensive screening system for damaged nucleotide-binding proteins.2010
- Author(s)
  Tsuchimoto, D., T.Iyama, M.Nonaka, N.Abolhassani, E.Ohta, K.Sakumi, Y.Nakabeppu.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 37-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Abolhassani, N., T.Iyama, D.Tsuchimoto, K.Sakumi, M.Ohno, M.Behmanesh, Y.Nakabeppu.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 2891-2903
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 38 Pages: 2891-2903
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241013
[Journal Article] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single strand breaks in nuclear DNA with growth arrest2010
- Author(s)
  Iyama T, Abolhassani N, Tsuchimoto D (責任著者), Nonaka M, Nakabeppu Y
- Journal Title
  
  Nucleic Acids Res. 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] ITPA protein, an enzyme that eliminates deaminated purine nucleoside triphosphates in cells.2010
- Author(s)
  Sakumi, K., N.Abolhassani, M.Behmanesh, T.Iyama, D.Tsuchimoto, Y.Nakabeppu.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 43-50
- NAID
  120005227205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals2010
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D(共同責任著者), Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y(共同責任著者)
- Journal Title
  
  Nucleic Acids Res. 15
- NAID
  120005227421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] NUDT16 is a (deoxy) inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
- Author(s)
  Iyama, T., N.Abolhassani, D.Tsuchimoto, M.Nonaka, Y.Nakabeppu.
- Journal Title
  
  Nucleic Acids Res
  
  Volume: 38 Pages: 4834-4843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] A comprehensive screening system for damaged nucleotide-binding proteins.2010
- Author(s)
  Tsuchimoto D., et al.
- Journal Title
  
  Mutation Research
  
  Volume: 703 Pages: 37-42
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21117512
[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
- Author(s)
  Nakabeppu, Y., S.Oka, Z.Sheng, D.Tsuchimoto, K.Sakumi.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 51-58
- NAID
  120005227112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Journal Article] Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase2009
- Author(s)
  Nonaka M, Tsuchimoto D(責任著者), Sakumi K, Nakabeppu Y
- Journal Title
  
  preferring 5-iodocytosine. FEBS J. 276(6)
  
  Pages: 1654-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.2009
- Author(s)
  Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T.
- Journal Title
  
  Int Immunol. 8
  
  Pages: 947-55
- NAID
  10025387710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] ITPase-deficient mice show growth retardation and die before weaning2009
- Author(s)
  Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y(責任著者)
- Journal Title
  
  Cell Death Differ. 10
  
  Pages: 1315-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.2008
- Author(s)
  Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y(責任著者)
- Journal Title
  
  DNA Repair (Amst). 7(9)
  
  Pages: 1437-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.2008
- Author(s)
  Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y(責任著者).
- Journal Title
  
  EMBO J. 27(2)
  
  Pages: 421-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.2008
- Author(s)
  Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y(責任著者)
- Journal Title
  
  DNA Repair (Amst). 7(3)
  
  Pages: 418-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Oxidative Damage in Nucleic Acids and Parkinson's Disease.2007
- Author(s)
  Nakabeppu, Y., Tsuchimoto, D., Yamaguchi, H., Sakumi, K.
- Journal Title
  
  J.Neurosci.Res. 85・5
  
  Pages: 919-934
- NAID
  120000985083
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] APE1-and APE2-dependent DNA breaks in immunoglobulin class switch recombination.2007
- Author(s)
  Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE.
- Journal Title
  
  J Exp Med. 204(12)
  
  Pages: 3017-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390114
[Journal Article] Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids.2006
- Author(s)
  Nakabeppu, Y., Sakumi, K., Sakamoto, K., Tsuchimoto, D., Tsuzuki, T., Nakatsu,Y.
- Journal Title
  
  Biol.Chem. 387・4
  
  Pages: 373-379
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] MTH1,an oxidized purine nucleoside triphosphatase,prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.2006
- Author(s)
  Nakabeppu, Y., Kajitani, K., Sakamoto, K., Yamaguchi, H., Tsuchimoto,D.
- Journal Title
  
  DNA Repair 5・7
  
  Pages: 761-772
- Data Source
  KAKENHI-PROJECT-16390119
[Journal Article] A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.2006
- Author(s)
  Ohno, M., Miura, T., Furuichi, M., Tominaga, Y., Tsuchimoto, D., Sakumi, K., Nakabeppu,Y.
- Journal Title
  
  Genome Res. 16・5
  
  Pages: 567-575
- Data Source
  KAKENHI-PROJECT-16390119
[Presentation] マウスモデルを用いた早期乳児てんかん性脳症EIEE35の発症メカニズムの解明2022
- Author(s)
  土本大介
- Organizer
  第６４回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06869
[Presentation] マウスモデルを用いた早期乳児てんかん性脳症EIEE35の発症メカニズムの解明2022
- Author(s)
  土本大介
- Organizer
  第64回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06869
[Presentation] 神経幹細胞特異的イノシン三リン酸分解酵素ノックアウトマウスは脳神経細胞脱分極とてんかん発作を示す2021
- Author(s)
  土本大介
- Organizer
  2020年度先端モデル動物支援プラットフォーム成果発表会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] 神経幹細胞特異的Itpaノックアウトマウスは神経細胞脱分極とてんかん様けいれん発作を示し、早期に死亡する2020
- Author(s)
  土本大介、古賀祐一郎、林良憲、アボルハッサニ・ノナ、米嶋康臣、作見邦彦、中西博、豊國伸哉、中別府雄作
- Organizer
  第４３回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] ITPA欠損によるヒトてんかん性脳症のモデルとしての神経幹細胞特異的Itpaノックアウトマウス2019
- Author(s)
  4.土本　大介, 古賀　祐一郎, 林　良憲, アボルハッサニ　ノナ, 米嶋　康臣, 中西　博, 豊國　伸哉, 中別府　雄作
- Organizer
  平成30年度先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] マウスにおける神経幹細胞特異的ITPA欠損は神経細胞の脱分極を引き起こし，てんかん性発作と早期死亡の原因となる2019
- Author(s)
  土本大介，古賀祐一郎，林良憲，アボルハッサニノナ，米嶋康臣，作見邦彦，中西博，豊國伸哉，中別府雄作
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 加齢雌マウス脳に蓄積する8-オキソグアニンは海馬歯状回と大カレハ島の神経新生を障害し性的二形性をきたす2019
- Author(s)
  春山直樹，作見邦彦，加藤木敦央，土本大介，中別府雄作
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in dentate gyrus and major island of Calleja, and thus causing sexually dimorphic phenotypes2019
- Author(s)
  Yusaku Nakabeppu, Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Neural stem cell specific ITPA deficiency causes depolarization of neurons, resulting in epileptic seizure and early death in mice.2019
- Author(s)
  Daisuke Tsuchimoto, Yuichiro Koga, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, and Yusaku Nakabeppu
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] Defense mechanisms against the dysfunction resulting from damage to the genome by reactive oxygen species during aging2019
- Author(s)
  Naoki Haruyama, Nona Abolhassani, Guianfranco Mazzei, Julio Leon, Zijing Sheng, Sugako Oka, Mizuki Ohno, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 2019 International Association of Gerontology and Geriatrics (IAGG) Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Accumulation of 8-oxoguanine in nuclear genome of neural progenitors in aged mouse brain causes atrophy of major island of Calleja resulting in locomotor hyperactivity2018
- Author(s)
  Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 41st Annual Meeting of The Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Neural stem cell-specific Itpa knockout mouse as a model of human ITPA deficiency2018
- Author(s)
  1.Daisuke Tsuchimoto, Yuichiro Koga, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Hiroshi Nakanishi, Yusaku Nakabeppu
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] Oxidative DNA damage and Repair in Cancer and Aging2018
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Eiko Ohta, Zijing Sheng, Mizuki Ohno, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  The 14th Japan - Korea Joint Symposium on Cancer and Ageing Research
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] ITPA欠損によるヒトてんかん性脳症のモデルとしての神経幹細胞特異的Itpaノックアウトマウス2018
- Author(s)
  3.土本　大介, 古賀　祐一郎, 林　良憲, アボルハッサニ　ノナ, 米嶋　康臣, 中西　博, 中別府　雄作
- Organizer
  第41回日本分子生物学会年会出席
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] Neural stem cell-specific Itpa knockout mouse as a model of human ITPA deficiency2018
- Author(s)
  2.Daisuke Tsuchimoto, Yuichiro Koga, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Hiroshi Nakanishi, Yusaku Nakabeppu
- Organizer
  The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06960
[Presentation] 側坐核・カレハ島の新生GABAニューロンへの8-オキソグアニンの蓄積は加齢マウスの多動の原因となる2017
- Author(s)
  春山直樹, 作見邦彦, 加藤木　敦央, 土本大介, 中別府　雄作
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Nuclear accumulation of 8-oxoguanine in nucleus accumbens neurons contributes to age-related locomotor hyperactivity in Mth1/Ogg1-double knockout mice2017
- Author(s)
  Naoki Haruyama, Atsuhisa Katogi, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  九州大学教育改革シンポジウム2017
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Accumulation of 8-oxoguanine in the nuclei of newly-generated GABAergic neurons in the nucleus accumbens and islands of Calleja contributes to locomotor hyperactivity in aged mice2017
- Author(s)
  Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 27th Hot Spring Harbor International Symposium
- Data Source
  KAKENHI-PROJECT-17H01391
[Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013
- Author(s)
  38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Gordon research conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復機構に依存した細胞増殖抑制とゲノム不安定性を引き起こす.2013
- Author(s)
  米嶋康臣, 土本大介, 外間政朗, Abolhassani Nona, 猪山輝昭, 作見邦彦, 塩見尚子, 森雅彦, 塩見忠博, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Comprehensive analysis of gene expression regulated by Fosb gene in brain-derived cells2013
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Noriko Yutsudo, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanism to maintain the low level of deoxyinosine in DNA.2013
- Author(s)
  Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Keystone Symposium on Genomic Instability and DNA Repair (X6)
- Place of Presentation
  Banff, Alberta, Canada
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb gene products regulate expression of C5ar1 and C5l2 genes and microglial activation.2013
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  The 43rd annual meeting of the Society for neuroscience
- Place of Presentation
  San Diego. CA, USA.
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb遺伝子産物は補体C5aレセプターの遺伝子発現を制御することにより，ミクログリアの活性化に寄与している．2013
- Author(s)
  能丸寛子，作見邦彦，加藤木敦央，大西克典，梶谷康介，土本大介，Eric J. Nestler，中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 核酸損傷と生体防御2013
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
- Organizer
  第24回日本生体防御学会学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferating and differentiated human neuroblastoma cell line SH-SY5Y, and their modulation by BDNF and inhibitors for CDK5 and calpains.2013
- Author(s)
  Erika Castillo, Julio Leon, 秋本頼子, 作見邦彦, 岡素雅子, 土本大介, 中別府雄作
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2013
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi & Yusaku Nakabeppu
- Organizer
  Gordon Research Conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cross-talk between insulin and other growth factors signaling regulate their neuroprotective functions.2013
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Erika Castillo, Yusaku Nakabeppu
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Synergistic interaction between insulin and other growth factors modulates their neuroprotective functions.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine causes complex neurodegeneration in a MUTYH-dependent manner, which can be efficiently suppressed by MTH1 and/or OGG1.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  Yumebutai, Awaji, Hyogo
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB遺伝子産物によるアナフィラトキシンC5a走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
- Author(s)
  能丸寛子，作見邦彦，土本大介，中別府雄作
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスは MUTYH による塩基除去修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012
- Author(s)
  盛子敬，岡素雅子，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides.2012
- Author(s)
  Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Nakabeppu Y, Samson LD
- Organizer
  7th Annual CEHS Poster Session
- Place of Presentation
  Cambridge, MA, USA
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cytotoxic effects of X-ray irradiation on proliferative and differentiated human neuroblastoma cell line, SH-SY5Y, and modulation by neurotrophic factors and CDK5 inhibitor.2012
- Author(s)
  Erika Castillo, Julio Leon, Yoriko Akimoto, Yasuto Yoneshima, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 9th ASMRM and Chinese Mit'2012
- Place of Presentation
  Beijing, China
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Cooperative neuroprotection by insulin and neurotrophic factors.2012
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells.2012
- Author(s)
  Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Tetsuo Noda and Yusaku Nakabeppu
- Organizer
  4th US-JAPAN DNA REPAIR MEETING
- Place of Presentation
  Virginia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Obesity and altered expression of genes related to Diabetes-mellitus in Alzheimer’s disease mouse model.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] fosB遺伝子産物によるアナフィラトキシンC5a 走化性受容体遺伝子C5arとGpr77の発現制御機構の解析.2012
- Author(s)
  能丸寛子，作見邦彦，土本大介，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Obesity and altered expression of genes related to diabetes mellitus in a transgenic mouse model of Alzheimer's disease.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 2-OH-ATP as a signal molecule for the oxidative stress in mammalian cells。2012
- Author(s)
  Eiko Ohta, Kunihiko Sakumi, Daisuke Tsuchimoto, Yuka Takiguchi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYHはp53による発がん抑制のメディエータである.2012
- Author(s)
  岡素雅子，レオンフリオ，土本大介，作見邦彦，中別府雄作
- Organizer
  第35回日本がん疫学・分子疫学研究会総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Alzheimer’s disease mouse model exhibits altered expression of genes related to diabetes-mellitus with obesity.2012
- Author(s)
  Sugako Oka, Masaaki Hokama, Julio Leon, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 哺乳動物のITP 分解酵素とエンドヌクレアーゼV.2012
- Author(s)
  作見邦彦，土本大介，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性酸素による核酸の修飾とゲノム応答の遺伝学.2012
- Author(s)
  中別府雄作，土本大介，盛子敬，岡素雅子，作見邦彦
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] イノシン三リン酸によるゲノム不安定化機構と細胞内イノシン三リン酸生成経路の解明.2012
- Author(s)
  米嶋康臣，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair by MUTYH initiates calpain/PARP-dependent neurodegeneration under oxidative stress.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2011
- Author(s)
  中別府雄作, 猪山輝昭, 岡素雅子, 盛子敬, 作見邦彦, 土本大介
- Organizer
  第2回 Molecular Cardiovascular Conference
- Place of Presentation
  余市(招待講演)
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物細胞におけるデオキシイノシンヌクレオチドによるゲノム不安定化とその防御機構2011
- Author(s)
  土本大介, 猪山輝昭, アボルハッサニノナ, 米嶋康臣, 作見邦彦, 中別府雄作
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  6th Global-COE Young Investigators Forum
- Place of Presentation
  Bintan Isaland, Indonesia.
- Year and Date
  2011-02-12
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Roles of insulin in survival and proliferation of SH-SY5Y neuroblastoma cells under neuronal differentiation2011
- Author(s)
  Julio Leon, Masaaki Hokama, Sugako Oka, Erika Castillo, Kunihiko Sakumi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 2-OH-ATP as a candidate molecule for the oxidative stress sensor in mammalian cells2011
- Author(s)
  Kunihiko Sakumi, Eiko Ohta, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2011
- Author(s)
  太田詠子, 土本大介, 作見邦彦, 瀧口友香, 中別府雄作
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism of genome instability triggered by deoxyinosine nucleotides and defense systems in mammalian cells2011
- Author(s)
  Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物細胞におけるデオキシイノシンヌクレオチドによるゲノム不安定化機構とその防御システム2011
- Author(s)
  土本大介, 他8名
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市、パシフィコ横浜(ポスター発表)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-23117713
[Presentation] MUTYHはp53による発がん抑制のメディエータである2011
- Author(s)
  岡素雅子, フリオレオン, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第40回日本環境変異原学会シンポジウム
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2011
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  Keystone Symposia on Genomic Instability and DNA Repair
- Place of Presentation
  Keystone, Colorado, USA.
- Year and Date
  2011-02-01
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスはDNA修復酵素MUTYHに依存して神経変性を引き起こす2011
- Author(s)
  盛子敬, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第4回Kyushu CVD Conference
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物細胞におけるデオキシイノシンヌクレオチドによるゲノム不安定化とその防御機構2011
- Author(s)
  土本大介, 他5名
- Organizer
  日本遺伝学会第83回大会
- Place of Presentation
  京都市、京都大学農学部(ワークショップ発表)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PUBLICLY-23117713
[Presentation] 酸化ヌクレオチド2-OH-ATPによる細胞死の制御機構2010
- Author(s)
  太田詠子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16は(デオキシ)イノシンニリン酸分解酵素であり、その欠損は核DNAの一本鎖切断の蓄積と増殖抑制をもたらす2010
- Author(s)
  土本大介, 他4名
- Organizer
  BMB2010
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PUBLICLY-21117512
[Presentation] Deoxyinosine incorporated into DNA under ITPA deficiency2010
- Author(s)
  Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態2010
- Author(s)
  中別府雄作, 猪山輝昭, Nona Abolhassani, 太田詠子, 盛子敬, 岡素雅子, 作見邦彦, 土本大介
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality control in the purine nucleotide pools is essential for maintaining genomic integrity in mammals.2010
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Teruaki Iyama, Zijing Sheng, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16は(デオキシ)イノシン二リン酸分解酵素であり,その欠損は核DNAの一本鎖切断の蓄積と増殖抑制をもたらす2010
- Author(s)
  土本大介, 猪山輝昭, アボルハッサニノナ, 野中麻里, 中別府雄作
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] The biological significance of ITPA protein and its substrates, ITP and dITP in mouse2010
- Author(s)
  Kunihiko Sakumi, Nona Abolhassani, Mehrdad Behmanesh, Teruaki Iyama, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.2010
- Author(s)
  Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Mizuki Ohno, Mehrdad Behmanesh, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest.2010
- Author(s)
  Teruaki Iyama, Nona Abolhassani, Daisuke Tsuchimoto, Mari Nonaka, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mitochondrial toxin, 3-nitropropionic acid induces striatal degeneration through the two distinct MUTYH-dependent cell death pathways.2010
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻に起因するゲノム障害とその防御機構2010
- Author(s)
  中別府雄作, Nona Abolhassani, 猪山輝昭, 太田詠子, 盛子敬, 岡素雅子, 土本大介, 作見邦彦
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ヒトnudt16は(デオキシ)イノシン二リン酸を(デオキシ)イノシン一リン酸に加水分解する新規ヌクレオチドプール浄化酵素である2009
- Author(s)
  土本大介、猪山輝昭、アボルハッサニ・ノナ、中別府雄作
- Organizer
  2009年第20回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市琵琶湖コンファレンスセンター
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein.2009
- Author(s)
  Daisuke Tsuchimoto, et al.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PUBLICLY-21117512
[Presentation] ヒトNUDT16は(デオキシ)イノシンニリン酸を(デオキシ)イノシンーリン酸に加水分解する新規ヌクレオチドプール浄化酵素である2009
- Author(s)
  土本大介, ら
- Organizer
  第20回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市琵琶湖コンファレンスセンター
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PUBLICLY-21117512
[Presentation] Yusaku Nakabeppu Human NUDT16 is a novel nucleotide pool sanitizing enzyme hydrolyzing (deoxy)inosine diphosphate to (deoxy)inosine monophosphate.2009
- Author(s)
  Daisuke Tsuchimoto, Teruaki Iyama, Nona Abolhassani
- Organizer
  2009年第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein.2009
- Author(s)
  aisuke Tsuchimoto, Eiji Iwama, Teruaki Iyama, Yusaku Nakabeppu
- Organizer
  2009年第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] ヒトNUDT16は(デオキシ)イノシンニリン酸を(デオキシ)イノシンーリン酸に加水分解する新規ヌクレオチドプール浄化酵素である2009
- Author(s)
  土本大介, ら、
- Organizer
  第20回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市琵琶湖コンファレンスセンター
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Human NUDT16 is a novel nucleotide pool sanitizing enzyme hydrolyzing(deoxy)inosine diphosphate to(deoxy)inosine monophosphate2009
- Author(s)
  Tsuchimoto D, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Human NUDT16 is a novel nucleotide pool sanitizing enzyme hydrolyzing (deoxy) inosine diphosphate to (deoxy) inosine monophosphate2009
- Author(s)
  Tsuchimoto D, et al.
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PUBLICLY-21117512
[Presentation] Human NUDT16 Is a Novel Nucleotide Pool Sanitizing Enzyme Hydrolyzing (Deoxy)Inosine Diphosphate to (Deoxy)Inosine Monophosphate.2009
- Author(s)
  Teruaki Iyama, Daisuke Tsuchimoto, Nona Abolhassani, Yusaku Nakabeppu
- Organizer
  The 49th annual meeting of the American Society for Cell Biology, San Diego Convention Center, San Diego
- Place of Presentation
  CA, USA
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析2009
- Author(s)
  土本大介ら
- Organizer
  日本分子生物学会・日本生化学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Yusaku Nakabeppu An increased expression of NUDT16 with IDP/dIDP hydrolyzing activity in immortalized ITPA-null mouse embryonic fibroblasts suppressed ITPA-deficient phenotypes.2009
- Author(s)
  Nona Abolhassani, Teruaki Iyama, Daisuke Tsuchimoto, Kunihiko Sakumi, Mizuki Ohno, Behmanesh Mehrdad
- Organizer
  2009年第32回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Identification of the full-length form of Prune2, a neuroblastoma-related protein.2009
- Author(s)
  Daisuke Tsuchimoto, et al.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  愛知県名古屋市名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 核とミトコンドリアゲノムへの8-oxoguanineの同時蓄積によって起動されるプログラム細胞死2008
- Author(s)
  岡素雅子、大野みずき、土本大介、作見邦彦、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 新規損傷ヌクレオチド浄化酵素ITPBP2の同定と機能解析2008
- Author(s)
  土本大介、吉田菜桜子、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 哺乳動物細胞における2-OH-ATPの生物学的影響2008
- Author(s)
  太田詠子、土本大介、大野みずき、作見邦彦、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Novel pathway for hydrolysis of inosine nucleotides detected in immortalized ITPA-null mouse embryo fibroblasts2008
- Author(s)
  アボルハッサニ・ノナ、作見邦彦、大野みずき、土本大介、ベーマネッシュ・メールダート、中別府雄作
- Organizer
  2008年第31回日本分子生物学会・第81回日本生化学会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] Nitric oxide induces cell death through oxidation of mitochondrial deoxynucleotide pools.2007
- Author(s)
  市川淳二、土本大介、岡素雅子、大野みずき、作見邦彦、中別府雄作
- Organizer
  2007年第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] ITP結合タンパク質ITPBP1の生化学的特性の解析2007
- Author(s)
  野中麻里、土本大介、太田詠子、作見邦彦、中別府雄作
- Organizer
  2007年第30回日本分子生物学会・第80回日本生化学会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19390114
[Presentation] 放射線照射によって生成される損傷プリンヌクレオシドの同定と定量
- Author(s)
  秋本頼子, Nona Abolhassani, Erika Castillo, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] The human NEI endonuclease VIII-like 3 (NEIL3) is a novel gene associated with the development of auto-antibodies
- Author(s)
  Michel J. Massaad, Daisuke Tsuchimoto, Janet Chou, Toshiro Ohsumi, Jia Zhou, Haifa Jabara, Jennifer Kane, Klaus Schmitz, Markianos Kyriacos, Kumiko Torisu, Yusaku Nakabeppu, Peter Kang, Eliane Choueiry, Andre Megarbane, Masayuki Mizui, George Tsokos, Waleed El-Herz, Luigi Notarangelo, Susan Wallace, Raif S. Geha
- Organizer
  16th Biennial Meeting of the European Society for Immunodeficiency
- Place of Presentation
  Prague，Czech Republic
- Year and Date
  2014-10-29 – 2014-11-01
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Accumulation of deoxyinosine triphosphate induces mismatch repair-dependent cell growth arrest and instability of genomic DNA.
- Author(s)
  Yasuto Yoneshima, Daisuke Tsuchimoto, Nona Abolhassani, Teruaki Iyama, Kunihiko Sakumi, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Yusaku Nakabeppu
- Organizer
  International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb遺伝子産物はマクロファージにおける補体C5a受容体遺伝子，C5ar1とC5ar2の発現を制御する
- Author(s)
  森岡紀子, 能丸寛子, 作見邦彦, 土本大介, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Microglial activation by Fosb gene.
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Yoshinori N Ohnishisi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  International Symposium between Kyushu University Post-Global Centers of Excellence Program and School of Biomedical Sciences, Monash University
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia
- Author(s)
  Hiroko Nomaru, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] デオキシイノシン三リン酸の蓄積はミスマッチ修復タンパク質MLH1に依存した細胞周期の遅延をもたらす
- Author(s)
  土本大介, 米嶋康臣, Nona Abolhassani, 猪山輝昭, 作見邦彦, 塩見尚子, 森雅彦, 塩見忠博, 野田哲生, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004

1. NAKABEPPU Yusaku (30180350)

# of Collaborated Projects: 6 results

# of Collaborated Products: 104 results
2. SAKUMI Kunihiko (50211933)

# of Collaborated Projects: 3 results

# of Collaborated Products: 71 results
3. OKA Sugako (80467894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
4. SHENG Zijing (90467895)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. AKIMOTO Yoriko (50613254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. OHYAGI Yasumasa (30301336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林良憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tsuchimoto Daisuke 土本 大介

TSUCHIMOTO Daisuke 土本 大介

Research Projects

Research Products

Co-Researchers

イノシン三リン酸分解酵素欠損の分子病態解明Principal Investigator

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Elucidation of molecular pathogenesis of ITPA deficiency and development of its treatmentPrincipal Investigator

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Review Section

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Investigation of brain damage caused by reactive oxygen species and its defense mechanisms

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ＡＴＰの酸化体によるシグナル伝達Principal Investigator

Principal Investigator

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Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress

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環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明

Principal Investigator

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ATPおよびGTPの酸化体による細胞内シグナル伝達機構の解明Principal Investigator

Principal Investigator

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Review Section

Research Institution

Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse modelsPrincipal Investigator

Principal Investigator

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Molecular pathological analysis of defects in DNA base excision repair system using gene modified micePrincipal Investigator

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[Journal Article] Neural stem cell?specific ITPA deficiency causes neural depolarization and epilepsy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway2017

Author(s)

Journal Title

DOI

Data Source

Tsuchimoto Daisuke 土本大介

TSUCHIMOTO Daisuke 土本大介