Matsubara Yumiko 松原由美子

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MATSUBARA Yumiko 松原由美子

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Researcher Number	70365427
Other IDs
Affiliation (based on the past Project Information) *help	2023: 慶應義塾大学, 医学部(信濃町), 共同研究員 2016 – 2022: 慶應義塾大学, 医学部(信濃町), 特任准教授 2015 – 2016: 慶應義塾大学, 医学部, 准教授 2014: 慶應義塾大学, 医学部, 特任准教授 2013 – 2014: 慶應義塾大学, 医学部, 講師 … More 2011: 慶應義塾大学, 医学部, 特任講師 2010: 慶應義塾大学, 医学部・臨床検査医学, 講師 2009 – 2010: Keio University, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator Hematology Except Principal Investigator Plastic surgery / Basic Section 55030:Cardiovascular surgery-related / Basic Section 55020:Digestive surgery-related / Digestive surgery / Hematology
Keywords	Principal Investigator 巨核球 / 血小板 / 細胞・組織 / 再生医学 / 脂肪幹細胞 / トランスクリプトーム解析 / 分化誘導 / 血小板輸血 / 遺伝子ターゲティング / 造血幹細胞 / 脂肪組織 / 輸血学 … More Except Principal Investigator … More 血小板 / 間葉系幹細胞 / 再生医療 / ASCL / 細胞シート / 再生医学 / 血管内膜肥厚 / 肝虚血再灌流血流障害 / 肝移植 / 虚血再灌流 / 発癌予防法 / 線維化改善 / 経口血小板増多薬 / 経口血小板増多剤 / トロンボポエチン / 肝再生 / 抗がん作用 / 肝線維化改善 / 肝細胞癌 / 肝硬変 / 細胞分化運命制御 / 細胞運命制御 / 分化誘導 / 脂肪前駆細胞 / 造血幹細胞 / 骨髄脂肪変性 / 巨核球 / 血栓止血学 Less

間葉系幹細胞/間質細胞株（ASCL）細胞シートによる血管内膜肥厚の抑制
- Principal Investigator
  
  松原健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Keio University
Evaluation of Adipose-derived Mesenchymal Stem/stromal Cell Line (ASCL) therapy for hepatic ischemia/reperfusion injury and application to liver transplantation
- Principal Investigator
  
  OBARA Hideaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Keio University
The autologus cure by manufactureing platelets from a human cell line
- Principal Investigator
  
  YAZAWA Masaki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Keio University
Establishment of new treatment by thrombopoietin receptor agonist for liver regeneration in liver cirrhosis and for prevention of liver carcinogenes
- Principal Investigator
  
  OHKOHCHI Nobuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  University of Tsukuba
Identification and characterization of pre megakaryocytic progenitor cells from adipose-derived stem cellsPrincipal Investigator
- Principal Investigator
  
  Matsubara Yumiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University
Basic studies on the autologous cure by manufacturing plateles
- Principal Investigator
  
  Yazawa Masaki
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Keio University
A study on cell-fate switching between megakaryocytes and adipocytes in bone marrow cells
- Principal Investigator
  
  IKEDA Yasuo
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Waseda University
Generation of platelets from human subcutaneous adipose tissues in a culture systemPrincipal Investigator
- Principal Investigator
  
  MATSUBARA Yumiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Keio University

All 2019 2018 2017 2016 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] Annual Review 2016 血液2016
- Author(s)
  小野―宇留賀友佳子、松原由美子
- Total Pages
  234
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26461410
[Book] ダイレクトリプログラミング2015
- Author(s)
  小野―宇留賀友佳子、松原由美子
- Total Pages
  119
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-26461410
[Book] ファーマコナビゲーターシリーズ　抗凝固療法編2015
- Author(s)
  松原由美子
- Total Pages
  413
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26461410
[Book] 血栓・止血ハンドブック2014
- Author(s)
  松原由美子、村田満
- Total Pages
  422
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-26461410
[Book] Annual Review 2014 血液2014
- Author(s)
  松原由美子
- Total Pages
  240
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-26461410
[Book] Platelets and Megakaryocytes, Methods and Protocols2011
- Author(s)
  Yumiko Matsubara, Mitsuru Murata, Yasuo Ikeda
- Total Pages
  500
- Publisher
  Springer(印刷中)
- Data Source
  KAKENHI-PROJECT-21591250
[Book] Platelets and Megakaryocytes, Methods and Protocols2011
- Author(s)
  Yuuiko Matsubara, Mitsuru Nurata, Yasuo Ikeda
- Total Pages
  500
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Megakaryocytes and platelets from a novel human adipose tissue?derived mesenchymal stem cell line2019
- Author(s)
  Tozawa Keiichi、Ono-Uruga Yukako、Yazawa Masaki、Mori Taisuke、Murata Mitsuru、Okamoto Shinichiro、Ikeda Yasuo、Matsubara Yumiko
- Journal Title
  
  Blood
  
  Volume: 133 Issue: 7 Pages: 633-643
- DOI
  10.1182/blood-2018-04-842641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11379
[Journal Article] in vitroでの血小板産生2017
- Author(s)
  松原由美子
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 27 Pages: 532-537
- NAID
  130005421276
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] 体細胞から直接血小板を作成する技術2016
- Author(s)
  小野―宇留賀友佳子、松原由美子
- Journal Title
  
  医学のあゆみ
  
  Volume: 257 Pages: 213-218
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] アナグレライド2016
- Author(s)
  戸澤圭一、松原由美子
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 27 Pages: 49-53
- NAID
  130005127659
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] Human adipose tissue-derived stromal cells can differentiate into　megakaryocytes and platelets by secreting endogenous thrombopoietin.2016
- Author(s)
  Ono-Uruga Y, Tozawa K, Horiuchi T, Murata M, Okamoto S, Ikeda Y, Suda T,Matsubara Y.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: 未定 Issue: 6 Pages: 1-13
- DOI
  10.1111/jth.13313
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461410, KAKENHI-PROJECT-26221309
[Journal Article] Direct reprogramming of fibroblasts and preadipocytes into functional megakaryocytes2014
- Author(s)
  Yumiko Matsubara
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 55 Pages: 387-395
- NAID
  130004920664
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] マウスおよびヒト線維芽細胞から血小板への直接リプログラミング2014
- Author(s)
  松原由美子
- Journal Title
  
  細胞
  
  Volume: 46 Pages: 8-11
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] Megakaryopoiesis2014
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Yumiko Matsubara
- Journal Title
  
  Clin Exp Thromb Hemost
  
  Volume: 1 Issue: 2 Pages: 54-58
- DOI
  10.14345/ceth.14014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461410
[Journal Article] Culture of megakaryocytes and platelets from subcutaneous adipose tissue and a preadipocyte cell line2012
- Author(s)
  Matsubara Y, Murata M, Ikeda Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 788 Pages: 249-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Culture of megakaryocytes and platelets from subcutaneous adipose tissue and a preadipocyte cell line2012
- Author(s)
  Matsubara Y, Murata M, Ikeda Y
- Journal Title
  
  Methods Mol Biol
  
  Volume: 788 Pages: 249-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Effect of chronic kidney disease on platelet reactivity to dual-antiplatelet therapy in patients treated with drug-eluting stents2011
- Author(s)
  Arai T, Kawamura A, Matsubara Y, Yokoyama K, Ikeda, Y, Fukuda K, Murata M
- Journal Title
  
  Heart Vessels
  
  Volume: (Epub ahead of print) Pages: 249-258
- DOI
  10.1007/978-1-61779-307-3_17
- ISBN
  9781617793066, 9781617793073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro2011
- Author(s)
  Ono M, Matsubara Y, Shibano T, Ikeda Y, Murata M
- Journal Title
  
  Platelets
  
  Volume: 22 Issue: 3 Pages: 196-203
- DOI
  10.3109/09537104.2010.541959
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250, KAKENHI-PROJECT-22659183
[Journal Article] Effect of chronic kidney disease on platelet reactivity to dual-antiplatelet therapy in patients treated with drug-eluting stents2011
- Author(s)
  Arai T, Kawamura A, Matsubara Y, Yokoyama K, Ikeda Y, Fukuda K, Murata M
- Journal Title
  
  Heart Vessels
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] GSK-3beta negatively regulates megakaryocyte differentiation and platelet production from human bone marrow cells in vitro.2011
- Author(s)
  Ono Mayumi, Yumiko Matsubara.Yoshiro Shibano, Yasuo Ikeda, Mitsuru Murata
- Journal Title
  
  Platelets
  
  Volume: 22 Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] GSK-3beta negatively regulates megakaryocyte differentiation and platelet production from human bone marrow cells in vitro2011
- Author(s)
  Ono M, Matsubara Y, Shibano Y, Ikeda Y, Murata M
- Journal Title
  
  Platelets
  
  Volume: 22 Pages: 196-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Low Responsiveness to Antiplatelet Drugs2011
- Author(s)
  Matsubara Y
- Journal Title
  
  J Jpn Coll Angiol
  
  Volume: 51 Pages: 309-314
- NAID
  10029767464
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Effect of chronic kidney disease on platelet reactivity to dual-antiplatelet therapy in patients treated with drug-eluting stents2011
- Author(s)
  Arai T, Kawamura A, Matsubara Y, Yokoyama K, Ikeda Y, Fukuda K, Murata M
- Journal Title
  
  Heart Vessels
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] GSK-3beta negatively regulates megakaryocyte differentiation and platelet production from human bone marrow cells in vitro2011
- Author(s)
  Ono M, Matsubara Y, Shibano Y, Ikeda Y, Murata M
- Journal Title
  
  Platelets
  
  Volume: 22 Pages: 196-203
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Low Responsiveness to Antiplatelet Drugs2011
- Author(s)
  Matsubara Y
- Journal Title
  
  J Jpn Coll Angiol
  
  Volume: 51 Pages: 309-314
- NAID
  10029767464
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] GSK-3beta negatively regulates megakaryocyte differentiation and platelet production from human bone marrow cells in vitro.2010
- Author(s)
  Mayumi Ono, Yumiko Matsubara, Yasuo Ikeda, Mitsuru Murata
- Journal Title
  
  Platelets
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] 巨核球・血小板のin vitro分化誘導法2010
- Author(s)
  松原由美子
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 21(5) Pages: 509-513
- NAID
  10027675094
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Generation of megakaryocytes and platelets from preadipocyte cell line 3T3-L1, but not the parent cell line 3T3, in vitro.2010
- Author(s)
  Yumiko Matsubara, Hidenori Suzuki, Yasuo Ikeda, Mitsuru Murata
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 796-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] 巨核球・血小板のin vitro分化誘導法2010
- Author(s)
  松原由美子
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 21(5) Pages: 509-513
- NAID
  10027675094
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Generation of megakaryocytes and platelets from preadipocyte cell line 3T3-L1, but not the parent cell line 3T3, in vitro2010
- Author(s)
  Matsubara Y, Suzuki H, Ikeda Y, Murata M
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 796-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Culture of Megakaryocytes and Platelets from Subcutateous Adipose Tissue and Preadipocyte Cell Line2010
- Author(s)
  Matsubara Y, Murata M, Ikeda Y
- Journal Title
  
  Methods and Protocols (in press)
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Generation of megakaryocytes and platelets from preadipocyte cell line 3T3-L1, but not the parent cell line 3T3, in vitro2010
- Author(s)
  Matsubara Y, Suzuki H, Ikeda Y, Murata M
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 402 Pages: 796-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Generation of megakaryocytes and platelets from preadipocyte cell line 3T3-L1, but not the parent cell line 3T3, in vitro.2010
- Author(s)
  Yumiko Matsubara, Hidenori Suzuki, Yasuo Ikeda, Mitsuru Murata
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 402 Pages: 796-800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659183
[Journal Article] Generation of megakaryocytes and platelets from human subcutaneous adipose tissues2009
- Author(s)
  Matsubara Y, Saito E, Suzuki H, Watanabe N, Murata M, Ikeda Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 378 Pages: 716-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] Generation of megakaryocytes and platelets from human subcutaneous adipose tissues2009
- Author(s)
  Matsubara Y, Saito E, Suzuki H, Watanabe N, Murata M, Ikeda Y
- Journal Title
  
  Biochem Biophys Res Commun 378
  
  Pages: 716-720
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] 血小板・凝固線溶系検査の解釈2009
- Author(s)
  松原由美子
- Journal Title
  
  日本内科学会誌 98
  
  Pages: 19-24
- NAID
  10025192885
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article]2009
- Author(s)
  Matsubara Y, Murata M, Ikeda Y
- Journal Title
  
  Telomeres : Function, Shortening and Lengtheing(Nova Science Publishers, Inc)
  
  Pages: 403-413
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] 総説血小板産生機構2009
- Author(s)
  松原由美子
- Journal Title
  
  最新医学・新しい診断と治療のABC
  
  Volume: 63 Pages: 9-16
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] 総論血小板・凝固線溶系検査の解釈2009
- Author(s)
  松原由美子
- Journal Title
  
  日本内科学会誌
  
  Volume: 98 Pages: 19-24
- Data Source
  KAKENHI-PROJECT-21591250
[Journal Article] 血小板産生機構2009
- Author(s)
  松原由美子
- Journal Title
  
  最新医学・新しい診断と治療のABC 63
  
  Pages: 9-16
- Data Source
  KAKENHI-PROJECT-21591250
[Patent] 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤2019
- Inventor(s)
  松原由美子、矢澤真樹、森泰昌
- Industrial Property Rights Holder
  慶應義塾大学
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2019-034917
- Filing Date
  2019
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-16K11379
[Patent] Agent for promoting wound healing comprising platelet-like cell co-expressing platelet surface antigen and mesenchymal cell surface antigen2018
- Inventor(s)
  Matsubara, Yazawa, Mori
- Industrial Property Rights Holder
  Keio University
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K11379
[Patent] 血小板表面抗原と間葉系細胞表面抗原を共発現する血小板様細胞を含む創傷治癒促進剤2018
- Inventor(s)
  松原由美子、矢澤真樹、森泰昌他
- Industrial Property Rights Holder
  学校法人　慶應義塾
- Industrial Property Rights Type
  特許
- Patent Publication Number
  2019-034917
- Filing Date
  2018
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] 皮下脂肪組織に由来する間葉系間質細胞株からの血小板創製技術の医療応用2017
- Author(s)
  松原由美子
- Organizer
  第24回　血液代替物学会学術総会
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] Effects of Activated Human Platelet Releases on Wound Healing Immunodeficient Mice: Comparison with basic FGF.2017
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Taisuke Mori, Noriko Takizawa, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara, Masaki Yazawa
- Organizer
  XXVI The International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] Function of Manufactured Platelets from Adipose Stem Cell Line: Compared to Platelet Concentrates2017
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  第79回　日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] 皮下脂肪組織に由来する間葉系間質細胞株からの血小板創製技術の医療応用2017
- Author(s)
  松原由美子
- Organizer
  第7回　レギュラトリーサイエンス学会学術総会
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] c-MPL Adipose-derived Stromal Cells as a Megakaryocyte-biased Cells by a Single Cell Analysis2016
- Author(s)
  Noriko Takizawa, Yukako Ono-Uruga, Keiichi Tozawa, Yasuo Ikeda, Yumiko Matsubara;
- Organizer
  第78回　日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Manufacture of Platelets from Human Adipose Tissue-derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Platelet Concentrates.2016
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Noriko Takizawa, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  58th American Society of Hematology
- Place of Presentation
  サンディエゴ (アメリカ)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Manufacture of Platelets from Human Adipose Tissue-derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Platelet Concentrates2016
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Noriko Takizawa, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  The 58th the American Society of Hematology (ASH) annual meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462800
[Presentation] Manufacture of Platelets from Human Adipose Tissue-derived Mesenchymal Stromal/Stem Cells: Functional Comparison to Platelet Concentrates2016
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Masaki Yazawa, Taisuke Mori, Noriko Takizawa, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  The 58th the American Society of Hematology (ASH) annual meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11379
[Presentation] 巨核球・血小板産生研究の新展開2016
- Author(s)
  松原由美子
- Organizer
  第38回　日本血栓止血学会
- Place of Presentation
  奈良春日野国際フォーラム (奈良県奈良市)
- Year and Date
  2016-06-16
- Invited
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Establishment of Human Adipose Tissue-derived Stromal Cell Lines: a Culture System to Manufacture Megakaryocytes Releasing Functional Platelets.2015
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Noriko Takizawa, Tadashi Horiuchi, Shinichiro Okamoto, Mitsuru Murata, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  アメリカ血液学会
- Place of Presentation
  オーランド（アメリカ）
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Characterization of MPL in Human Pre-adipocytes and Its Role in Megakaryocyte Differentiation.2015
- Author(s)
  Yukako Ono-Uruga, Keiichi Tozawa, Noriko Takizawa, Tadashi Horiuchi, Mitsuru Murata, Shinichiro Okamoto, Yasuo Ikeda, Yumiko Matsubara
- Organizer
  日本血液学会学術集会
- Place of Presentation
  ホテル金沢 (石川県金沢市)
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] 脂肪幹細胞 (脂肪前駆細胞) 由来の巨核球・血小板2015
- Author(s)
  松原由美子
- Organizer
  日本輸血・細胞治療学会総会
- Place of Presentation
  京王プラザホテル (東京都新宿区)
- Year and Date
  2015-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Establishment and Characterization of Human Pre-adipocyte Cell Line for Manufacturing Platelets.2015
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Noriko Takizawa, Tadashi Horiuchi, Yasuo Ikeda, Shin-ichiro Okamoto, Yumiko Matsubara
- Organizer
  日本血液学会学術集会
- Place of Presentation
  ホテル金沢 (石川県金沢市)
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Identification of Megakaryocytic Progenitor Cells among Subcutaneous Pre-adipocytes Thrombopoietin.2015
- Author(s)
  Keiichi Tozawa, Yukako Ono-Uruga, Tadashi Horiuchi, Shinichiro Okamoto, Mitsuru Murata, Yasuo Ikeda, Toshio Suda, Yumiko Matsubara
- Organizer
  国際血栓止血学会
- Place of Presentation
  トロント（カナダ）
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] ヒト脂肪前駆細胞からの巨核球分化誘導システム:トランスフェリン/CD71/TPO 分泌機序を介した高効率産生.2015
- Author(s)
  戸澤圭一、小野―宇留賀友佳子、堀内正、村田満、岡本真一郎、池田康夫、須田年生、松原由美子
- Organizer
  日本血栓止血学会学術集会
- Place of Presentation
  甲府市総合市民会館 (山梨県甲府市)
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Yuhuan Wang, Yukako Ono, Yasuo Ikeda, Shinichiro Okamoto, Mitsuru Murata, Mortimer Poncz, Yumiko Matsubara
- Organizer
  53^<rd> The American Society of Hematology
- Place of Presentation
  San Diego (USA)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Wang Y, Ono Y, Ikeda Y, Okamoto S, Murata M, Poncz M, Matsubara Y
- Organizer
  53^<rd> The American Society of Hematology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Differentiation of OP9 Bone Marrow Stroma Cells into Megakaryocytes and Platelets via a p45NF-E2-mediated Mechanism2011
- Author(s)
  Yumiko Matsubara, Yukako Ono, Hidenori Suzuki, Fumio Arai, Toshio Suda, Mitsuru Murata, Yasuo Ikeda
- Organizer
  XXIII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  京都
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Yuhuan Wang, Yukako Ono, Yasuo Ikeda, Shinichiro Okamoto, Mitsuru Murata, Mortimer Poncz, Yumiko Matsubara
- Organizer
  53^<rd> The American Society of Hematology
- Place of Presentation
  San Diego (USA)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Differentiation of OP9 Bone Marrow Stroma Cells into Megakaryocytes and Platelets via a p45NF-E2-mediated Mechanism2011
- Author(s)
  Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y
- Organizer
  XXIII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Ono Y, Matsubara Y, Iida K, Suzuki H, Ikeda Y, Okamoto S, Murata M
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Differentiation of OP9 Bone Marrow Stroma Cells into Megakaryocytes and Platelets via a p45NF-E2-mediated Mechanism2011
- Author(s)
  Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y
- Organizer
  XXIII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Wang Y, Ono Y, Ikeda Y, Okamoto S, Murata M, Poncz M, Matsubara Y
- Organizer
  53^<rd> The American Society of Hematology
- Place of Presentation
  San Diego(USA)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Induction of Megakaryocytes from Fibroblasts by p45NF-E2/Maf2011
- Author(s)
  Ono Y, Matsubara Y, Iida K, Suzuki H, Ikeda Y, Okamoto S, Murata M
- Organizer
  第73回日本血液学会
- Place of Presentation
  名古屋国際会議場(名古屋)
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Generation of Megakaryocytes from Mouse Subcutaneous Adipose Tissues in vitro2010
- Author(s)
  Sonoda A, Matsubara Y, Suzuki H, Ikeda Y, Matsuo K, Murata M
- Organizer
  第72回日本血液学会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Generation of Megakaryocytes from Mouse Subcutaneous Adipose Tissues in vitro.2010
- Author(s)
  Akira Sonoda, Yumiko Matsubara, Hidenori Suzuki, Yasuo Ikeda
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Generation of Megakaryocytes from Mouse Subcutaneous Adipose Tissues in vitro2010
- Author(s)
  Sonoda A, Matsubara Y, Suzuki H, Ikeda Y, Matsuo K, Murata M
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜パシィフィコ(横浜)
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22659183
[Presentation] Generation of Megakaryocytes from Mouse Subcutaneous Adipose Tissues in vitro.2010
- Author(s)
  Akira Sonoda, Yumiko Matsubara, Hidenori Suzuki, Yasuo Ikeda, Koichi Matsuo, Mitsuru Murata
- Organizer
  第72回日本血液学会
- Place of Presentation
  横浜
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] 抗血小板剤の臨床薬理2009
- Author(s)
  松原由美子、村田満
- Organizer
  弟10回日本検査血液学会
- Place of Presentation
  甲府
- Year and Date
  2009-07-05
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] アスピリン服用によるGPIbαのsheddingと血小板機能抑制効果2009
- Author(s)
  山地賢三郎、松原由美子、星野晴彦、鈴木則宏、池田康夫、村田満
- Organizer
  弟32回日本血栓止血学会
- Place of Presentation
  北九州
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Effect of aspirin administration on GPIb alpha shedding : association of glycocalycin level with platelet sensitivity to aspirin2009
- Author(s)
  山地賢三郎, 松原由美子, 星野晴彦, 鈴木則宏, 池田康夫, 村田満
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] 血小板CD109の血小板機能調節における役割2009
- Author(s)
  松本公宏、松原由美子、星野晴彦、横山健次、芝野俊郎、鈴木則宏、池田康夫、村田満
- Organizer
  第32回日本血栓止血学会
- Place of Presentation
  リーガロイヤルホテル(北九州)
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Could D-dimer in the type 2 diabetic patients be a marker of the macrovascular complications2009
- Author(s)
  Yokoyama K, Tsukada Y, Matsubara Y, Kawai Y, Oikawa Y, Shimada A, Itoh H, Murata M, Ikeda Y
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] ヒト皮下脂肪組織からのin vitro分化誘導による巨核球分化・血小板産生2009
- Author(s)
  松原由美子
- Organizer
  第32回日本血栓止血学会
- Place of Presentation
  リーガロイヤルホテル(北九州)
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] 血小板産生におけるGSK-3bの役割: in vitro分化誘導法による検討2009
- Author(s)
  小野眞由美、松原由美子、芝野俊郎、池田康夫、村田満
- Organizer
  第32回日本血栓止血学会
- Place of Presentation
  リーガロイヤルホテル(北九州)
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] GSK-3 negatively regulates thrombopoiesis in an in vitro normal human CD34-positive cell-derived differentiation system2009
- Author(s)
  小野眞由美, 松原由美子, 芝野俊郎, 池田康夫, 村田満
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Effect of aspirin administration on GPIb alpha shedding : association of glycocalycin level with platelet sensitivity to aspirin2009
- Author(s)
  Yamaji K, Matsubara Y, Hoshino H, Suzuki N, Ikeda Y, Murata M
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] An inhibitory role of platelet CD 109 in platelet function2009
- Author(s)
  Matsumoto K, Matsubara Y, Hoshino H, Yokoyama K, Watanabe G, Shibano T, Suzuki N, Ikeda Y, Murata M
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] An inhibitory role of platelet CD109 in platelet function2009
- Author(s)
  Matsumoto K, Matsubara Y, Hoshino H, Yokoyama K, Watanabe G, Shibano T, Suzuki N, Ikeda Y, Murata M
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] GSK-3 negatively regulates thrombopoiesis in an in vitro normal human CD34-positive cell-derived differentiation system2009
- Author(s)
  Ono M, Matsubara Y, Shibano T, Ikeda Y, Mitsuru Murata
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston(USA)
- Year and Date
  2009-07-14
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] ヒト皮下脂肪組織からのin vitro分化誘導による巨核球分化・血小板産生2009
- Author(s)
  松原由美子
- Organizer
  弟32回日本血栓止血学会
- Place of Presentation
  北九州
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] Could D-dimer in the type 2 diabetic patients be a marker of the macrovascular complications2009
- Author(s)
  Yokoyama K, Tsukada Y, Matsubara Y, Kawai Y, Oikawa Y, Shimada A, Itoh H, Murata M, Ikeda Y
- Organizer
  XXII The International Society on Thrombosis and Haemostasis
- Place of Presentation
  Boston
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] 血小板CD109の血小板機能調節における役割2009
- Author(s)
  松本公宏、松原由美子、星野晴彦、横山健次、芝野俊郎、鈴木則宏、池田康夫、村田満
- Organizer
  弟32回日本血栓止血学会
- Place of Presentation
  北九州
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] 血小板産生におけるGSK-3βの役割:in vitro分化誘導法による検討2009
- Author(s)
  小野眞由美、松原由美子、芝野俊郎、池田康夫、村田満
- Organizer
  弟32回日本血栓止血学会
- Place of Presentation
  北九州
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PROJECT-21591250
[Presentation] ヒト脂肪前駆細胞からの巨核球分化誘導システム:トランスフェリン/CD71/TPO 分泌機序を介した高効率産生
- Author(s)
  戸澤圭一、小野―宇留賀友佳子、堀内正、村田満、岡本真一郎、池田康夫、須田年生、松原由美子
- Organizer
  第37回日本血栓止血学会
- Place of Presentation
  甲府 (甲府市総合市民会館)
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] 脂肪幹細胞 (脂肪前駆細胞) 由来の巨核球・血小板
- Author(s)
  松原由美子
- Organizer
  第63回日本輸血学会
- Place of Presentation
  東京 (京王プラザホテル)
- Year and Date
  2015-05-28 – 2015-05-30
- Invited
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] A Novel Mechanism of Megakaryopoiesis from Pre-adipocytes: Involvement of Transferrin/ CD71/ TPO Pathways
- Author(s)
  Yukako Ono-Uruga, Keiichi Tozawa, Sahoko Matsuoka, Tadashi Horiuchi, Shinichiro Okamoto, Mitsuru Murata, Yasuo Ikeda, Toshio Suda, Yumiko Matsubara
- Organizer
  56rd The American Society of Hematology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-12-05 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-26461410
[Presentation] Megakaryocyte Differentiation from Preadipocytes through the Production of Endogenous Thrombopoietin via CD71
- Author(s)
  Yukako Ono-Uruga, Sahoko Matsuoka, Tadashi Horiuchi, Shinichiro Okamoto, Mitsuru Murata, Yasuo Ikeda, Toshio Suda, and Yumiko Matsubara.
- Organizer
  第76回日本血液学会
- Place of Presentation
  大阪 (大阪国際会議場)
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26461410

1. Yazawa Masaki (60327567)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. OBARA Hideaki (20276265)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 森泰昌 (00296708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 福田和正 (50348786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. IKEDA Yasuo (00110883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
6. OHKOHCHI Nobuhiro (40213673)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 千葉満 (20583735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 村田聡一郎 (40436275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 倉田昌直 (20538665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 松岡佐保子 (20317340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 松原健太郎 (70348671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Matsubara Yumiko 松原 由美子

MATSUBARA Yumiko 松原 由美子

Research Projects

Research Products

Co-Researchers

間葉系幹細胞/間質細胞株（ASCL）細胞シートによる血管内膜肥厚の抑制

Principal Investigator

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Review Section

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Evaluation of Adipose-derived Mesenchymal Stem/stromal Cell Line (ASCL) therapy for hepatic ischemia/reperfusion injury and application to liver transplantation

Principal Investigator

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Review Section

Research Institution

The autologus cure by manufactureing platelets from a human cell line

Principal Investigator

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Research Institution

Establishment of new treatment by thrombopoietin receptor agonist for liver regeneration in liver cirrhosis and for prevention of liver carcinogenes

Principal Investigator

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Research Institution

Identification and characterization of pre megakaryocytic progenitor cells from adipose-derived stem cellsPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Basic studies on the autologous cure by manufacturing plateles

Principal Investigator

Project Period (FY)

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Research Institution

A study on cell-fate switching between megakaryocytes and adipocytes in bone marrow cells

Principal Investigator

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Research Institution

Generation of platelets from human subcutaneous adipose tissues in a culture systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Annual Review 2016 血液2016

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Data Source

[Book] ダイレクトリプログラミング2015

Author(s)

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[Book] ファーマコナビゲーターシリーズ 抗凝固療法編2015

Author(s)

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[Book] 血栓・止血ハンドブック2014

Author(s)

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[Book] Annual Review 2014 血液2014

Author(s)

Total Pages

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[Book] Platelets and Megakaryocytes, Methods and Protocols2011

Author(s)

Matsubara Yumiko 松原由美子

MATSUBARA Yumiko 松原由美子

[Book] ファーマコナビゲーターシリーズ　抗凝固療法編2015

[Journal Article] Human adipose tissue-derived stromal cells can differentiate into　megakaryocytes and platelets by secreting endogenous thrombopoietin.2016