SHIME HIROAKI 志馬寛明

… Alternative Names

Shime Hiroaki 志馬寛明

SHIME Hiroaki 志馬寛明

志馬寛明シメヒロアキ

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Researcher Number	70372133
Other IDs
External Links
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 名古屋市立大学, 医薬学総合研究院(医学), 講師 2018: 名古屋市立大学, 大学院医学研究科, 講師 2017: 名古屋市立大学, 大学院医学研究科, 助教 2016: 北海道大学, 医学研究科, 助教 2012 – 2014: 北海道大学, 医学(系)研究科(研究院), 助教 … More 2013: 北海道大学, 大学院・大医学研究科, 助教 2010 – 2011: 北海道大学, 大学院・医学研究科, 助教 2008: Hokkaido University, 大学院・先端生命科学研究院, 特任助教 2007: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses, 研究所, 研究員 2005: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 研究員 2004: 大阪府立成人病センター(研究所), 研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Basic Section 49030:Experimental pathology-related / Bacteriology (including Mycology) Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Immunology / Biological Sciences
Keywords	Principal Investigator 自然免疫 / 免疫抑制 / TLR / MDSC / アジュバント / 癌 / RNAアジュバント / ミエロイド / がん免疫療法 / ミエロイド系細胞 … More / がん免疫 / 腫瘍免疫 / 癌免疫療法 / マクロファージ / 炎症 / 免疫調節 / IL-23 / 免疫制御 / 樹状細胞 / 皮膚 / 紫外線 / 創傷治癒 / 制御性T細胞 / toll-like receptor (TLR) / 腫瘍内微小環境 / TAM / インターフェロン / NK細胞 / IPS-1 MAVS / 免疫抑制細胞 / 腫瘍随伴マクロファージ(TAM) / 二本鎖RNA / poly I:C / 抗腫瘍免疫 / TRIF / TICAM-1 / 2本鎖RNA / TLR3 / Toll-likereceptor / TLR(toll-like recetor) / メモリーT細胞 / 抗原提示細胞 / Toll-like receptor(TLR) / IL-17 / 乳酸 / サイトカイン / Toll-like receptor / 肺癌 / IL-12 / PAMP / BCG-CWS / 免疫増強 … More Except Principal Investigator 樹状細胞 / 自然免疫 / Toll-like receptor / 口腔癌 / 補体 / 免疫担当細胞 / 自己免疫疾患 / 病巣感染 / IPS-1 / TICAM-1 / インターフェロン / TICAM-1経路 / MyD88 経路 / Toll-like receptor (TLR) / 腫瘍浸潤マクロファージ / 発がん・抗がん微小環境 / マクロファージ / 抗がん免疫 / パターン認識 / Toll like receptor Less

Elucidation of a novel control mechanism of regulatory T cells in human head and neck squamous cell carcinoma
- Principal Investigator
  
  Imai Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Nagoya City University
Functional characterization of ultraviolet-expanded regulatory T cells in skinPrincipal Investigator
- Principal Investigator
  
  Shime Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Nagoya City University
Mechanisms of autoimmune diseases triggered by infectious foci and treatment strategies
- Principal Investigator
  
  山崎小百合
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Nagoya City University
Anti-tumor immune responses mediated by TLR-activated tumor-associated myeloid cellsPrincipal Investigator
- Principal Investigator
  
  Shime Hiroaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya City University
  Hokkaido University
Regulation of function of tumor-infiltrating myeloid cells by RNA adjuvantPrincipal Investigator
- Principal Investigator
  
  SHIME Hiroaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
Molecular mechanisms of dendritic cell maturation in response to pattern sensing
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
感染発がんを変調する宿主炎症応答機構
- Principal Investigator
  
  SEYA Tsukasa
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Functional conversion of tumor-supporting myeloid cells to tumoricidal effectors by dsRNA adjuvantPrincipal Investigator
- Principal Investigator
  
  SHIME Hiroaki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
Analysis of the immune response enhanced by tumor-secreted lactic acidPrincipal Investigator
- Principal Investigator
  
  SHIME Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hokkaido University
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
微生物成分に対する自然免疫応答を癌が増強するメカニズムの解析Principal Investigator
- Principal Investigator
  
  志馬寛明
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses

[Book] Advanced technologies for adjuvant research and development抗がん免疫アジュバントの開発と現状2011
- Author(s)
  瀬谷司,佐藤治子,志馬寛明,松本美佐子
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer2023
- Author(s)
  Minohara K, Imai M, Matoba T, Wing JB, Shime H, Odanaka M, Uraki R, Kawakita D, Toyama T, Takahashi S, Morita A, Murakami S, Ohkura N, Sakaguchi S, Iwasaki S, Yamazaki S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 114 Issue: 4 Pages: 1256-1269
- DOI
  10.1111/cas.15698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09911
[Journal Article] Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens2021
- Author(s)
  Uraki Ryuta、Imai Masaki、Ito Mutsumi、Shime Hiroaki、Odanaka Mizuyu、Okuda Moe、Kawaoka Yoshihiro、Yamazaki Sayuri
- Journal Title
  
  PLOS Pathogens
  
  Volume: 17 Issue: 12 Pages: e1010085-e1010085
- DOI
  10.1371/journal.ppat.1010085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19KK0202
[Journal Article] Reply to Slominski et al.: UVB irradiation induces proenkephalin+ regulatory T cells with a wound-healing function2021
- Author(s)
  Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 3
- DOI
  10.1073/pnas.2021919118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19KK0202, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-20H03469, KAKENHI-PROJECT-18K16158
[Journal Article] Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function2020
- Author(s)
  Shime Hiroaki、Odanaka Mizuyu、Tsuiji Makoto、Matoba Takuma、Imai Masaki、Yasumizu Yoshiaki、Uraki Ryuta、Minohara Kiyoshi、Watanabe Maiko、Bonito Anthony John、Fukuyama Hidehiro、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi、Yamazaki Sayuri
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 34 Pages: 20696-20705
- DOI
  10.1073/pnas.2000372117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07334, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-20K09911, KAKENHI-PROJECT-19K18779, KAKENHI-PROJECT-19KK0202, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-19H04812, KAKENHI-PROJECT-20H03469, KAKENHI-PROJECT-18K16158, KAKENHI-PROJECT-20H03703, KAKENHI-PROJECT-20K16265, KAKENHI-PROJECT-19K23868
[Journal Article] Hyperglycemia is associated with psoriatic inflammation in both humans and mice2019
- Author(s)
  Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 印刷中 Issue: 6 Pages: 1329-1338
- DOI
  10.1016/j.jid.2019.01.029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07071, KAKENHI-PUBLICLY-17H05798, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-19K07510, KAKENHI-PROJECT-19KK0202, KAKENHI-PUBLICLY-19H04812, KAKENHI-PUBLICLY-19H04813, KAKENHI-PROJECT-17H04242, KAKENHI-PROJECT-17K11679
[Journal Article] Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy2019
- Author(s)
  Yoshida Sumito、Shime Hiroaki、Matsumoto Misako、Kasahara Masanori、Seya Tsukasa
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10
- DOI
  10.3389/fimmu.2019.00671
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-19KK0202
[Journal Article] Type I Interferon-Independent Dendritic Cell Priming and Antitumor T Cell Activation Induced by a Mycoplasma fermentans Lipopeptide2018
- Author(s)
  Takeda Yohei、Azuma Masahiro、Funami Kenji、Shime Hiroaki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9
- DOI
  10.3389/fimmu.2018.00496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08704
[Journal Article] Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models.2018
- Author(s)
  Takeda Y, Yoshida S, Takashima K, Ishii‐Mugikura N, Shime H, Seya T, Matsumoto M.
- Journal Title
  
  Cancer science
  
  Volume: 109 Issue: 7 Pages: 2119-2129
- DOI
  10.1111/cas.13649
- NAID
  120006502508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06484, KAKENHI-PROJECT-16K08704
[Journal Article] TLRアゴニストを用いた抗癌免疫アジュバント療法2018
- Author(s)
  志馬寛明、松本美佐子、山崎小百合、瀬谷　司
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 8(2) Pages: 5-12
- Data Source
  KAKENHI-PROJECT-16K08704
[Journal Article] Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model2018
- Author(s)
  Yoshida Sumito、Shime Hiroaki、Takeda Yohei、Nam Jin-Min、Takashima Ken、Matsumoto Misako、Shirato Hiroki、Kasahara Masanori、Seya Tsukasa
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 4 Pages: 956-965
- DOI
  10.1111/cas.13543
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-15H04716
[Journal Article] Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.2017
- Author(s)
  Shime H, Matsumoto M, Seya T.
- Journal Title
  
  Cell Death & Differentiation
  
  Volume: 24 Issue: 3 Pages: 385-396
- DOI
  10.1038/cdd.2016.131
- NAID
  120006337763
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08704
[Journal Article] Ultraviolet B?Induced Maturation of CD11b-Type Langerin?Dendritic Cells Controls the Expansion of Foxp3+Regulatory T Cells in the Skin2017
- Author(s)
  Yamazaki Sayuri、Odanaka Mizuyu、Nishioka Akiko、Kasuya Saori、Shime Hiroaki、Hemmi Hiroaki、Imai Masaki、Riethmacher Dieter、Kaisho Tsuneyasu、Ohkura Naganari、Sakaguchi Shimon、Morita Akimichi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 200 Issue: 1 Pages: 119-129
- DOI
  10.4049/jimmunol.1701056
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-17K11679, KAKENHI-PROJECT-17K19568, KAKENHI-PROJECT-16H06295, KAKENHI-PUBLICLY-17H05798, KAKENHI-PUBLICLY-17H05799, KAKENHI-PROJECT-15H04744, KAKENHI-PROJECT-16H05177, KAKENHI-PROJECT-17H04088, KAKENHI-PROJECT-15K08431, KAKENHI-PROJECT-16K15259, KAKENHI-PROJECT-16K15376, KAKENHI-PROJECT-17H04242
[Journal Article] The anti-oxidant ergothioneine augments the immunomodulatory function of TLR agonists by direct action on macrophages.2017
- Author(s)
  Yoshida, S., Shime, H., Funami, K., Takaki, H., Tomiyama, T., Matsumoto, M., Kasahara, M. and Seya, T.
- Journal Title
  
  PLoS ONE
  
  Volume: 12 Issue: 1 Pages: e0169360-e0169360
- DOI
  10.1371/journal.pone.0169360
- NAID
  120006219937
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04716, KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-16K19134
[Journal Article] Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cells2017
- Author(s)
  Shime Hiroaki、Maruyama Akira、Yoshida Sumito、Takeda Yohei、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  OncoImmunology
  
  Volume: 7 Issue: 1 Pages: e1373231-e1373231
- DOI
  10.1080/2162402x.2017.1373231
- NAID
  120006456415
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08704
[Journal Article] The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice2017
- Author(s)
  Ono Junya、Shime Hiroaki、Takaki Hiromi、Takashima Ken、Funami Kenji、Yoshida Sumito、Takeda Yohei、Matsumoto Misako、Kasahara Masanori、Seya Tsukasa
- Journal Title
  
  Journal of Biomedical Science
  
  Volume: 24 Issue: 1 Pages: 79-88
- DOI
  10.1186/s12929-017-0387-z
- NAID
  120006370604
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08704, KAKENHI-PROJECT-16K19134, KAKENHI-PROJECT-15H04716
[Journal Article] Live imaging of TAK1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyI:C.2016
- Author(s)
  Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M
- Journal Title
  
  Cancer Science
  
  Volume: Epub ahead of print Issue: 5 Pages: 644-652
- DOI
  10.1111/cas.12923
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26830070, KAKENHI-PROJECT-16K08704
[Journal Article] STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation2016
- Author(s)
  Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, Seya T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 478 Issue: 4 Pages: 1764-1771
- DOI
  10.1016/j.bbrc.2016.09.021
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704, KAKENHI-ORGANIZER-25112001
[Journal Article] Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.2016
- Author(s)
  Kasamatsu, J., Deng, M., Matsumoto, M., Azuma, M., Funami, K., Shime, H., Kasahara, M., Oshiumi, H. and Seya, T.
- Journal Title
  
  BMC Immunol.
  
  Volume: 17 Issue: 1 Pages: 9-9
- DOI
  10.1186/s12865-016-0147-y
- NAID
  120005766743
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04716, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K08704
[Journal Article] The role of innate immune signaling in regulation of tumor-associated myeloid cells2015
- Author(s)
  Shime H, Matsumoto M, Seya T
- Journal Title
  
  Inflammation and immunity in cancer
  
  Pages: 25-47
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.2015
- Author(s)
  Matsumoto M, Tatematsu M, Nishikawa F, Azuma M, Ishii N, Morii-Sakai A, Shime H, Seya T
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6280-6280
- DOI
  10.1038/ncomms7280
- NAID
  120005619610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] PolyI:C-induced, TLR3/RIP3-dependent necroptosis backs up immune effector-mediated tumor elimination in vivo.2015
- Author(s)
  Takemura R, Takaki H, Okada S, Shime H, Oshiumi H, Akazawa T, Matsumoto M, Tejima T, and Seya T.
- Journal Title
  
  Cancer Immunology Research
- NAID
  120005820710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.2015
- Author(s)
  Maruyama A, Shime H, Takeda Y, Azuma M, Matsumoto M, and Seya T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 457 Issue: 3 Pages: 445-450
- DOI
  10.1016/j.bbrc.2015.01.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Poly I:Cの刺激により活性化したミエロイド由来抑制性細胞はナチュラルキラー細胞に抗癌活性を付与する2014
- Author(s)
  志馬寛明、児島絢子、丸山晃、斉藤祐介、押海裕之、松本美佐子、瀬谷　司
- Journal Title
  
  北海道医学雑誌
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] dsRNAによるTAM、MDSCの腫瘍免疫抑制作用から活性化作用への変換2014
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Journal Title
  
  臨床・免疫アレルギー科
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic : polycytidylic acid treatment in mouse tumor models2014
- Author(s)
  Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
- Journal Title
  
  J Innate Immun
  
  Volume: 6 Pages: 293-305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] dsRNAによるTAM, MDSCの腫瘍免疫抑制作用から活性化作用への変換2014
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 61 Pages: 613-620
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor model.2014
- Author(s)
  Shime, H., A. Kojima, A. Maruyama, Y. Saito, H. Oshiumi, M. Matsumoto, and T. Seya.
- Journal Title
  
  J. Innate. Immun.
  
  Volume: 6 Issue: 3 Pages: 293-305
- DOI
  10.1159/000355126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590558, KAKENHI-PUBLICLY-24117702, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570
[Journal Article] 腫瘍浸潤マクロファージのRNA応答2014
- Author(s)
  瀬谷　司、志馬寛明、松本美佐子
- Journal Title
  
  細胞工学
  
  Volume: 33 Pages: 1242-1246
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] TLR3シグナル経路の活性化は腫瘍内ミエロイド系細胞を癌攻撃型エフェクターに転換する2013
- Author(s)
  志馬寛明、松本美佐子、押海裕之、田中伸哉、中根明夫、岩倉洋一郎、田原秀晃、井上徳光、瀬谷　司
- Journal Title
  
  北海道医学雑誌
  
  Volume: 88 Pages: 81-81
- NAID
  10031165881
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] Toll-like receptor (TLR)と制御性T細胞(Treg)2013
- Author(s)
  志馬寛明、瀬谷　司
- Journal Title
  
  週刊医学のあゆみ
  
  Volume: 246 Pages: 871-878
- Data Source
  KAKENHI-PROJECT-24590470
[Journal Article] TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.2012
- Author(s)
  Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M.
- Journal Title
  
  Oncoimmunol.
  
  Volume: 1 Issue: 6 Pages: 917-923
- DOI
  10.4161/onci.21244
- NAID
  120005228664
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24590570, KAKENHI-PROJECT-24659214, KAKENHI-PUBLICLY-24117702
[Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, Tahara H, Inoue N, Seya T
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109(6) Pages: 2066-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  H.Shime
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Issue: 6 Pages: 2066-2071
- DOI
  10.1073/pnas.1113099109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-21200079, KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21590326, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24659214
[Journal Article] TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors2012
- Author(s)
  Shime H, M. Matsumoto, H. Oshiumi, S. Tanaka, A. Nakane, Y. Iwakura, H. Tahara, N. Inoue, and T. Seya
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 109 Pages: 2066-2071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] TAMable tumor-associated macrophages in response to innate RNA sensing2012
- Author(s)
  Seya T, Shime H, Matsumoto M
- Volume
  (in press)
- NAID
  120005228653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] TAMable tumor-associated macrophages in response to innate RNA sensing.2012
- Author(s)
  Seya T, Shime H, Matsumoto M.
- Journal Title
  
  Oncoimmunol.
  
  Volume: 1 Issue: 6 Pages: 1000-1001
- DOI
  10.4161/onci.19894
- NAID
  120005228653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-24590470, KAKENHI-PROJECT-24659214
[Journal Article] IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.2011
- Author(s)
  Yabu M, Shime H
- Journal Title
  
  International Immunology
  
  Volume: 23 Pages: 29-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Natural killer cell activation secondary to innate pattern sensing2011
- Author(s)
  Seya T, Kasamatsu J, Azuma M, Shime H, Matsumoto M
- Journal Title
  
  J Innate Immun
  
  Volume: 3(3) Pages: 264-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] IL-23 dependent and-independent enhancement pathway of IL-17A production by lactic acid2011
- Author(s)
  Yabu, M., Shime, H., Hara, H., Saito, T., Matsumoto, M., Seya, T., Akazawa, T. and Inoue, N.
- Journal Title
  
  Intl Immunology
  
  Volume: 23(1) Issue: 1 Pages: 29-41
- DOI
  10.1093/intimm/dxq455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590326, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] Natural killer cell activation secondary to innate pattern sensing2011
- Author(s)
  Seya T, Kasamatsu J, Azuma M, et al
- Journal Title
  
  J Innate Immune
  
  Volume: 3 Issue: 3 Pages: 264-273
- DOI
  10.1159/000326891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-09J01843, KAKENHI-PROJECT-11J04706, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-23390120
[Journal Article] 腫瘍浸潤myeloid cellsによる免疫抑制2011
- Author(s)
  志馬寛明
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 56 Pages: 23-30
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.2011
- Author(s)
  Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Issue: 12 Pages: 10702-10711
- DOI
  10.1074/jbc.m110.185793
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22790320, KAKENHI-PROJECT-23390120
[Journal Article] 腫瘍浸潤myeloid cellsによる免疫抑制2011
- Author(s)
  志馬寛明、松本美佐子、瀬谷司
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: vol.56 Pages: 23-30
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Raftlin is involved in the nucleocapture complex to induce poly(I : C)-mediated TLR3 activation2011
- Author(s)
  Watanabe, A., M. Tatematsu, K. Saeki, S. Shibata, H. Shime, A. Yoshimura, C. Obuse, T. Seya, and M. Matsumoto
- Journal Title
  
  J. Biol. Chem
  
  Volume: 86 Pages: 10702-10711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390120
[Journal Article] Development of monoclonal antibodies that specifically interact with necrotic lymphoma cells2011
- Author(s)
  Wakasa K, Shime H, Kurita-Taniguchi M, Matsumoto M, Imamura M, Seya T
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55(5) Pages: 373-7
- NAID
  10031121481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] 自然免疫と癌治療2011
- Author(s)
  瀬谷司、押海裕之、志馬寛明、松本美佐子
- Journal Title
  
  実験医学
  
  Volume: vol.29 Pages: 111-118
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR22011
- Author(s)
  Sawahata R, Shime H, Yamazaki S, Inoue N, Akazawa T, Fujimoto Y, Fukase K, Matsumoto M, Seya T
- Journal Title
  
  Microbes Infect
  
  Volume: 13(4) Pages: 350-8
- NAID
  120002912001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] A rapid and simple PCR method for identifying isolates of the genus Azospirillum within populations of rhizosphere bacteria2011
- Author(s)
  Shime-Hattori A, Kobayashi S, Ikeda S, Asano R, Shime H, Shinano T
- Journal Title
  
  J Appl Microbiol
  
  Volume: 111(4) Pages: 915-924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] IL-23-dependent and-independent enhancement pathways of IL-17A production by lactic acid2011
- Author(s)
  Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, Akazawa T, Inoue N
- Journal Title
  
  Int. Immunol
  
  Volume: 23 Pages: 29-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV)2011
- Author(s)
  Aly, H.H., H.Oshiumi, H.Shime, M.Matsumoto, T.Wakita, K.Shimotohno, T.Seya
- Journal Title
  
  Plos ONE
  
  Volume: 6 Issue: 6 Pages: e21284-e21284
- DOI
  10.1371/journal.pone.0021284
- NAID
  120003169041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200079, KAKENHI-PUBLICLY-22021002, KAKENHI-PLANNED-22114008, KAKENHI-PUBLICLY-22117501, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-22790450, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558, KAKENHI-PROJECT-23659407
[Journal Article] Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I : C)-mediated TLR3 Activation2011
- Author(s)
  Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
- Journal Title
  
  J Biol Chem
  
  Volume: 286(12) Pages: 10702-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Development of monoclonal antibodies that specifically interact with necrotic lymphoma cells2011
- Author(s)
  Wakasa K, Shime H (equally contributed)
- Journal Title
  
  Microbiol Immunol
  
  Volume: 55 Issue: 5 Pages: 373-377
- DOI
  10.1111/j.1348-0421.2011.00319.x
- NAID
  10031121481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR22011
- Author(s)
  Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M. and Seya, T.
- Journal Title
  
  Microbes and Infection
  
  Volume: 13 Issue: 4 Pages: 350-358
- DOI
  10.1016/j.micinf.2010.12.003
- NAID
  120002912001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590326, KAKENHI-PLANNED-22114008, KAKENHI-PROJECT-22790371, KAKENHI-PROJECT-23241074, KAKENHI-PROJECT-23390088, KAKENHI-PROJECT-23390120, KAKENHI-PROJECT-23590558
[Journal Article] Pattern recognition receptors of innate immunity and their application to tumor immunotherapy2010
- Author(s)
  Seya T, Shime H, Ebihara T, Oshiumi H, Matsumoto M
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 313-320
- NAID
  10026587432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] Pattern-recognition receptors of innate immunity and their application to tumor immunotherapy. (review)2010
- Author(s)
  Seya, T., H.Shime, T.Ebihara, H.Oshiumi, M.Matsumoto
- Journal Title
  
  Cancer Sci.
  
  Volume: 101 Pages: 313-320
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008
[Journal Article] Adjuvant engineering for cancer immunotherapy : development of a synthetic TLR2 ligand with increased cell adhesion.2010
- Author(s)
  Akazawa, T., N.Inoue, H.Shime, K.Sugiura, K.Kodama, M.Matsumoto, T.Seya
- Journal Title
  
  Cancer Sci.
  
  Volume: 101 Pages: 1596-1603
- NAID
  10026594411
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22114008
[Journal Article] Adjuvant engineering for cancer immunotherapy : development of a synthetic TLR2 ligand with increased cell adhesion2010
- Author(s)
  Akazawa T, Inoue N, Shime H, Kodama K, Matsumoto M, Seya T
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 1596-1603
- NAID
  10026594411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790371
[Journal Article] TLR刺激によるTh17細胞の増加2009
- Author(s)
  志馬寛明、井上徳光、松本美佐子、瀬谷司
- Journal Title
  
  臨床免疫・アレルギー科 51巻
  
  Pages: 479-486
- Data Source
  KAKENHI-PROJECT-19790302
[Journal Article] Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway2008
- Author(s)
  Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N.
- Journal Title
  
  J Immunol. 180
  
  Pages: 7175-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790302
[Journal Article] Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.2008
- Author(s)
  Hiroaki Shime
- Journal Title
  
  The Journal of Immunology 掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] The role of regulatory T cells and dendritic cells in controlling the tumor microenvironment of human head and neck squamous cell carcinoma2022
- Author(s)
  Kiyoshi Minohara, Masaki Imai, Takuma Matoba, James Badger Wing, Hiroaki Shime, Mizuyu Odanaka, Ryuta Uraki, Akimichi Morita, Naganari Ohkura, Shimon Sakaguchi, Sayuri Yamazaki
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09911
[Presentation] Skin regulatory T cells expanded by ultraviolet B exposure have a unique gene expression profile compared to other tissue Treg cells.2021
- Author(s)
  Odanaka M, Shime H, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Transient depletion of Treg cells induces adaptive immunity to SARS-CoV-2 antigens.2021
- Author(s)
  Uraki R, Imai M, Shime H, Kawaoka Y, Yamazaki S
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09911
[Presentation] Transient depletion of Treg cells induces adaptive immunity to SARS-CoV-2 antigens.2021
- Author(s)
  Uraki R, Imai M, Shime H, Kawaoka Y, Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin regulatory T cells producing proenkephalin expand upon ultraviolet B exposure without ST2-IL33 axis and promote keratinocyte outgrowth.2021
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第46回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Proenkephalin+ regulatory T cells expanded by ultraviolet-B exposure maintain skin homeostasis with a healing function.2021
- Author(s)
  Shime H, Odanaka M, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] 制御性T細胞を標的としたSARS-CoV-2に対する新規予防法の開発2021
- Author(s)
  浦木隆太, 今井優樹, 伊藤睦美, 志馬寛明, 小田中瑞夕, 奥田萌, 河岡義裕, 山崎小百合
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin regulatory T cells expanded by ultraviolet B exposure have a unique gene expression profile compared to other tissue Treg cells.2021
- Author(s)
  Odanaka M, Shime H, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito AJ, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, Yamazaki S
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09911
[Presentation] Skin regulatory T cells expanded by ultraviolet B exposure have a unique gene expression profile compared to other tissue Treg cells.2021
- Author(s)
  Odanaka M, Shime H, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S.
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Transient depletion of Treg cells induces adaptive immunity to SARS-CoV-2 antigens.2021
- Author(s)
  Uraki R, Imai M, Shime H, Kawaoka Y, Yamazaki S.
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Skin regulatory T cells producing proenkephalin expand upon ultraviolet B exposure without ST2-IL33 axis and promote keratinocyte outgrowth.2021
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第46回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.2021
- Author(s)
  Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito AJ, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, Yamazaki S
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09911
[Presentation] Proenkephalin+ regulatory T cells expanded by ultraviolet-B exposure maintain skin homeostasis with a healing function.2021
- Author(s)
  Shime H, Odanaka M, Tsuiji M, Imai M, Yasumizu Y, Uraki R, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, and Yamazaki S.
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] 制御性T細胞を標的としたSARS-CoV-2に対する新規予防法の開発.2021
- Author(s)
  浦木隆太, 今井優樹, 伊藤睦美, 志馬寛明, 小田中瑞夕, 奥田萌, 河岡義裕, 山崎小百合
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure.2021
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第45回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure2020
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A
- Organizer
  The 45 th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-20K09911
[Presentation] Skin regulatory T cells possessing a healing function are expanded by ultraviolet-B exposure.2020
- Author(s)
  Yamazaki S, Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito A, Fukuyama H, Ohkura N, Sakaguchi S, Morita A.
- Organizer
  第45回日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells upon ultraviolet B exposure2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  Japan-Singapore Skin International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Regulatory T cells with a distinctive feature expand through dermal dendritic cells in the ultraviolet B exposed skin2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  16th international workshop on Langerhans cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] Regulatory T cells with a distinctive feature expand through dermal dendritic cells in the ultraviolet B exposed skin2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  16th international workshop on Langerhans cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Dermal dendritic cells present neo-self antigens induced by ultraviolet B exposure to expand Foxp3+ regulatory T cells2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  77th annual meeting of Society for investigative dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] 乾癬によって引き起こされる高血糖-臨床とマウスモデルによる解析2019
- Author(s)
  井汲今日子、小田中瑞夕、志馬寛明、今井優樹、大佐賀智、田口修、西田絵美、邊見弘明、改正恒康、山崎小百合、森田明理
- Organizer
  第34回日本乾癬学会学術大会
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Successful treatment of psoriatic inflammation improves hyperglycemia in humans and mice.2019
- Author(s)
  Mizuyu Odanaka, Kyoko Ikumi, Hiroaki Shime, Masaki Imai, Emi Nishida, Hiroaki Hemmi, Tsuneyasu Kaisho, Akimichi Morita, Sayuri Yamazaki
- Organizer
  The 48 th Annual Meeting of the Japanese Society of Immunology
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Dermal dendritic cells present neo-self antigens induced by ultraviolet B exposure to expand Foxp3+ regulatory T cells2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  77th annual meeting of Society for investigative dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Functional characterization of regulatory T (Treg) cells in UVB-irradiated skin2019
- Author(s)
  Hiroaki Shime, Mizuyu Odanaka, Masaki Imai, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, Sayuri Yamazaki
- Organizer
  第48回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in ApcMin/+ mice2019
- Author(s)
  Hiroaki Shime, Misako Matsumoto, Sayuri Yamazaki, Tsukasa Seya
- Organizer
  Nagoya Immunology Network in NCU
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] Functional characterization of regulatory T (Treg) cells in UVB-irradiated skin.2019
- Author(s)
  Hiroaki Shime, Mizuyu Odanaka, Masaki Imai, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, Sayuri Yamazaki
- Organizer
  The 48 th Annual Meeting of the Japanese Society of Immunology
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Skin dendritic cells expressing a unique set of genes associated with immunological tolerance are specialized to expand thymus-derived Foxp3+ regulatory T cells upon ultraviolet B exposure2019
- Author(s)
  Sayuri Yamazaki, Mizuyu Odanaka, Hiroaki Shime, Masaki Imai, Hiroaki Hemmi, Tsuneyasu Kaisho, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita
- Organizer
  Japan-Singapore Skin International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0202
[Presentation] Characterization of Foxp3+ Regulatory T cells Expanded in Ultraviolet-B-irradiated Skin2019
- Author(s)
  兼子ひとみ、小田中瑞夕、志馬寛明、山崎小百合
- Organizer
  【新学術ネオ・セルフ】第3回若手の会
- Data Source
  KAKENHI-PROJECT-19K07510
[Presentation] トル様受容体3リガンドは放射線の増感性免疫アジュバントとして機能する2018
- Author(s)
  吉田純人、志馬寛明、武田洋平、松本美佐子、瀬谷司
- Organizer
  第22回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in ApcMin/+ mice2018
- Author(s)
  Hiroaki Shime, Misako Matsumoto, Sayuri Yamazaki, Tsukasa Seya
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] TLR2シグナルはミエロイド由来抑制性細胞のがん免疫抑制作用を増強する2018
- Author(s)
  志馬寛明、松本美佐子、山崎小百合、瀬谷司
- Organizer
  第28回日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] Toll-like receptor 2 ligand and interferon-γ suppress anti-tumor T cell responses by enhancing the immunosuppressive activity of monocytic myeloid-derived suppressor cell.2017
- Author(s)
  Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.2017
- Author(s)
  Ken Takashima, Yohei Takeda, Hiroyuki Oshiumi, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
- Organizer
  The 36th Sapporo international cancer symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] Double-stranded RNA induces CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway2017
- Author(s)
  Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
- Organizer
  The 36th Sapporo international cancer symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] TLR3 adjuvant enhances tumor regression in concert with radiation therapy in mouse tumor-implant models.2017
- Author(s)
  Sumito Yoshida, Hiroaki Shime, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya
- Organizer
  The 36th Sapporo international cancer symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] PolyI:C-induced, TLR3/RIP3-dependent necroptosis backs up immune effector-mediated tumor elimination in vivo.2017
- Author(s)
  Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
- Organizer
  The 36th Sapporo international cancer symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] TLRシグナルの活性化による腫瘍内ミエロイド系免疫細胞の機能変化と腫瘍退縮機構2016
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Organizer
  日本インターフェロンサイトカイン学会
- Place of Presentation
  長崎大学坂本キャンパス良順会館　ポンペ会館（長崎県・長崎市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] T cell-derived IFN-γ is a critical factor for enhanced suppressive activity of M-MDSCs induced by TLR2 activation2016
- Author(s)
  Hiroaki Shime, Akira Maruyama, Misako Matsumoto, Tsukasa Seya
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] ApcMin/+マウスでのTICAM-1遺伝子欠損は腸ポリープ形成を促進する2016
- Author(s)
  尾野純也、志馬寛明、松本美佐子、瀬谷司
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08704
[Presentation] dsRNA adjuvant induces the antitumor function of tumor-associated myeloid cells.2014
- Author(s)
  Shime H, Matsumoto M, Seya T
- Organizer
  4th International symposium on carcinogenic spiral
- Place of Presentation
  札幌（京王プラザホテル）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] RNAアジュバントによる腫瘍随伴ミエロイド系細胞を介した抗癌作用2014
- Author(s)
  志馬　寛明、松本　美佐子、瀬谷　司
- Organizer
  がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  東京（一橋講堂）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] Supportive involvement of tumor-associated myeloid cells in RNA adjuvant therapy for cancer.2013
- Author(s)
  Shime H, Matsumoto M, Oshiumi H, Seya T
- Organizer
  ICI2013
- Place of Presentation
  ミラノ（MiCo）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] RNAアジュバントによる腫瘍内マクロファージの機能転換を介した新規抗腫瘍作用2013
- Author(s)
  志馬寛明、松本美佐子、押海裕之、瀬谷司
- Organizer
  「がん研究分野の特性等を踏まえた支援活動」　公開シンポジウム
- Place of Presentation
  学術総合センター一橋記念講堂（東京都）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] 担癌宿主で増加するCD11b+Gr1+細胞は2本鎖RNAの投与によりNK細胞活性化能を獲得する2012
- Author(s)
  志馬　寛明、児島　絢子、松本　美佐子、瀬谷　司
- Organizer
  日本がん免疫学会
- Place of Presentation
  北海道大学（札幌）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] NK cell activation by tumor-associated myeloid cells during RNA adjuvant therapy for cancer2012
- Author(s)
  Hiroaki SHIME, Misako MATSUMOTO, Tsukasa SEYA
- Organizer
  IEIIS2012
- Place of Presentation
  学術総合センター一橋記念講堂（東京都）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] A crucial RNA adjuvant for immunotherapy for cancer2012
- Author(s)
  Tsukasa Seya, Misako Matsumoto, Hiroaki Shime, Masahiro Azuma
- Organizer
  日本癌学会
- Place of Presentation
  さっぽろ芸文館（北海道）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] Splenic CD11b+Gr1+ cells turn NK activators by dsRNA in tumor-implant mice2012
- Author(s)
  Hiroaki SHIME, Misako MATSUMOTO, Tsukasa SEYA
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際展示場（兵庫県）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] The role of tumor-associated myeloid cells in RNA adjuvant therapy2012
- Author(s)
  Hiroaki SHIME, Misako MATSUMOTO, Tsukasa SEYA
- Organizer
  日本癌学会
- Place of Presentation
  札幌市教育文化会館（北海道）
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] Tumor-infiltrating macrophages turn tumoricidal through TLR3/TICAM-1 signal by dsRNA stimulation2011
- Author(s)
  Shime H
- Organizer
  The 16th Korea-Japan cancer research workshop
- Place of Presentation
  北海道大学(札幌市)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] 二本鎖RNAアジュバントによる腫瘍随伴マクロファージの活性化と抗腫瘍免疫応答2011
- Author(s)
  志馬寛明
- Organizer
  日本がん免疫学会
- Place of Presentation
  千里ライフサイエンスセンタービル(大阪府)
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Tumoricidal activity of tumor-associated macrophages induced by RNA adjuvant therapy2011
- Author(s)
  Shime H
- Organizer
  日本免疫学会
- Place of Presentation
  幕張メッセ(千葉県)
- Year and Date
  2011-12-28
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Tumoricidal activity of tumor-associated macrophages activated by RNA adjuvant2011
- Author(s)
  Shime H
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] 樹状細胞と腫瘍浸潤マクロファージのアジュバント応答2010
- Author(s)
  志馬寛明
- Organizer
  第14回日本がん免疫学会総会
- Place of Presentation
  KKRホテル熊本(熊本)
- Year and Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] 樹状細胞と腫瘍浸潤マクロファージのアジュバント応答2010
- Author(s)
  志馬寛明
- Organizer
  第14回日本がん免疫学会総会
- Place of Presentation
  KKRホテル熊本(熊本)(招待講演)
- Year and Date
  2010-07-23
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Possible contribution of tumor-infiltrating myeloid cells to anti-tumor immune response during RNA adjuvant therapy2010
- Author(s)
  志馬寛明
- Organizer
  平成22年度がん若手研究者ワークショップ
- Place of Presentation
  アートランドホテル蓼科(長野)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Tumor-infiltrating myeloid cells evoke in vivo tumoricidal activity by RNA adjuvant therapy2010
- Author(s)
  志馬寛明
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Tumor-infiltrating myeloid cells evoke in vivo tumoricidal activity by RNA adjuvant therapy2010
- Author(s)
  Shime H
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] Possible contribution of tumor-infiltrating myeloid cells to anti-tumor immune response during RNA adjuvant therapy2010
- Author(s)
  志馬寛明
- Organizer
  平成22年度がん若手研究者ワークショップ
- Place of Presentation
  アートランドホテル蓼科(長野)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22790371
[Presentation] 癌から分泌される乳酸はIL-23/IL-17経路を誘導する2008
- Author(s)
  志馬明
- Organizer
  日本分子生物学会第8回春季シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2008-05-26
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] 癌から分泌される乳酸はIL-23/IL-17経路を誘導する2008
- Author(s)
  志馬明
- Organizer
  第4回北海道癌免疫制御研究会
- Place of Presentation
  札幌
- Year and Date
  2008-06-07
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] Tumor-secreted lactic acid enhances IL-23-IL-17 pathway2008
- Author(s)
  Shime, H
- Organizer
  Keystone symposia
- Place of Presentation
  Santa Fe, USA
- Year and Date
  2008-02-13
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] Lactic acid is a modulator to activate the IL-23/IL-17 pathway in an Ag-dependent manner2008
- Author(s)
  志馬寛明
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] 癌から分泌される乳酸によるIL-23-IL-17炎症経路の誘導2007
- Author(s)
  志馬寛明
- Organizer
  第44回補体シンポジウム
- Place of Presentation
  神奈川
- Year and Date
  2007-08-25
- Data Source
  KAKENHI-PROJECT-19790302
[Presentation] TICAM-1 signaling is essential for Ly6G+ cell-mediated inhibition of tumor growth induced by dsRNA adjuvant
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] RNAアジュバントによるLy6G陽性細胞を介した抗がん作用
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Organizer
  日本がん免疫学会
- Place of Presentation
  ひめぎんホール（愛媛県・松山市）
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] TLR2 signal enhances survival and immune-suppressive activity of MDSCs
- Author(s)
  丸山　晃、志馬寛明、松本美佐子、瀬谷　司
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24590470
[Presentation] What immune responses are evoked by selective stimulation of the TLR3/TICAM-1 pathway in vaccination?
- Author(s)
  Seya T., Azuma M., Shime H., Matsumoto M.
- Organizer
  Keystone Symposia
- Place of Presentation
  Fairmont Chateau Laurier（Ottawa, Canada）
- Data Source
  KAKENHI-PROJECT-23390120
[Presentation] Ly6G+ cell-mediated retardation of tumor growth in RNA adjuvant therapy
- Author(s)
  志馬寛明、松本美佐子、瀬谷　司
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24590470

1. Imai Masaki (30440936)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
2. SEYA Tsukasa (10301805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
3. MATSUMOTO Misako (30332456)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. 山崎小百合 (70567255)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
5. OSHIUMI Hiroyuki (50379103)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 櫨木薫 (50146007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. PENMETCHA Kumar (80357938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小田中瑞夕 (00510281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
9. 的場拓磨 (40790712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 浦木隆太 (70843027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 上岡裕治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井上徳光

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 赤澤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 武田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 邊見弘明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 笠原正典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 築地信

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SHIME HIROAKI 志馬 寛明

Shime Hiroaki 志馬 寛明

SHIME Hiroaki 志馬 寛明

志馬 寛明 シメ ヒロアキ

Research Projects

Research Products

Co-Researchers

Elucidation of a novel control mechanism of regulatory T cells in human head and neck squamous cell carcinoma

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Functional characterization of ultraviolet-expanded regulatory T cells in skinPrincipal Investigator

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Mechanisms of autoimmune diseases triggered by infectious foci and treatment strategies

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Anti-tumor immune responses mediated by TLR-activated tumor-associated myeloid cellsPrincipal Investigator

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Regulation of function of tumor-infiltrating myeloid cells by RNA adjuvantPrincipal Investigator

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Molecular mechanisms of dendritic cell maturation in response to pattern sensing

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感染発がんを変調する宿主炎症応答機構

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Functional conversion of tumor-supporting myeloid cells to tumoricidal effectors by dsRNA adjuvantPrincipal Investigator

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Analysis of the immune response enhanced by tumor-secreted lactic acidPrincipal Investigator

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微生物成分に対する自然免疫応答を癌が増強するメカニズムの解析Principal Investigator

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[Book] Advanced technologies for adjuvant research and development抗がん免疫アジュバントの開発と現状2011

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[Journal Article] Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer2023

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[Journal Article] Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens2021

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DOI

SHIME HIROAKI 志馬寛明

Shime Hiroaki 志馬寛明

SHIME Hiroaki 志馬寛明

志馬寛明シメヒロアキ