OSHIRO Noriko 大城紀子

Researcher Number	70372662
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010: 神戸大学, 自然科学系先端融合研究環バイオシグナル研究センター, 助教 2008: Kobe University, 自然科学系先端融合研究環バイオシグナル研究センター, 助教 2007: Kobe University, バイオシグナル研究センター, 助教 2005 – 2006: 神戸大学, バイオシグナル研究センター, 助手
Review Section/Research Field	Principal Investigator General medical chemistry Except Principal Investigator General medical chemistry / Pathological medical chemistry / Biological Sciences
Keywords	Principal Investigator リン酸化部位特異的抗体 / PRAS40 / プロテインキナーゼ / ラパマイシン / mTOR / アミノ酸 / 栄養化学 / 細胞内シグナル伝達 Except Principal Investigator mTOR / ラパマイシン … More / アミノ酸 / PRAS40 / rapamycin / 細胞成長 / amino acids / side effect / restenosis prevention / cell growth / immunosuppressant / 血小板現象 / 中性脂肪上昇 / 創傷治癒遅延 / Rapamycin / タンパク質リン酸化 / 創傷治癒 / 血小板減少 / 4EBP1 / mTOR複合体 / raptor / リン酸化 / 副作用 / 再狭窄阻害 / 免疫抑制剤 / STAT3 / Rheb / TIP41 / PP242 / mTIP41 / AMPK / ホスファターゼ / 栄養 / シグナル伝達 / WDドメイン / mLST8 / 核酸生合成 / ピリミジン生合成 / CAD / 核酸新生 / 細胞増殖 / Tuberin / TSC / がん抑制遺伝子 / Hamartin / GAPドメイン / 結節性硬化症 Less

Regulation mechanisms of mTOR-mediated nutrient signaling by protein phosphatase PP2A
- Principal Investigator
  
  KIKKAWA Ushio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Studies of PRAS40, the novel substrate of mTOR that senses the nutritional environments and regulates cellular functionsPrincipal Investigator
- Principal Investigator
  
  OSHIRO Noriko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
mTORシグナルを介したがん抑制遺伝子TSCによる発がん機構の研究
- Principal Investigator
  
  YOSHINO Ken-ichi
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
アミノ酸バランスを感知するシグナル伝達機構と核酸生合成の研究
- Principal Investigator
  
  吉野健一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Study on the Mammalian target of rapamycin in thrombocytepoiesis, wound healing, and hyperlipemia
- Principal Investigator
  
  YOSHINO Ken-ichi, 米澤一仁
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University

All 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Mammalian Tti1 and Tel2 are critical factors in mTOR complex assembly.2010
- Author(s)
  Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S.I., Natsume, T., Mizushima, N.
- Journal Title
  
  J.Biol.Chem. 285(26)
  
  Pages: 20109-20116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390081
[Journal Article] Activation of mTORC1 in two steps : Rheb-GTP activation of catalytic function and increased binding of substrates to raptor2009
- Author(s)
  Avruch J., Long X., Lin Y., Ortiz-Vega S., Rapley J., Papageorgiou A., Oshiro N., Kikkawa U.
- Journal Title
  
  Biochem. Soc. Trans. 37
  
  Pages: 223-226
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] AMP-activated protein kinase phosphorylates glutamine:fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity2009
- Author(s)
  Eguchi S., Oshiro N., Miyamoto T., Yoshino K., Okamoto S., Ono T., Kikkawa U., Yonezawa K.
- Journal Title
  
  Genes Cells 14
  
  Pages: 179-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity.2009
- Author(s)
  Eguchi, S., Oshiro, N., Miyamoto, T., Yoshino, K., Okamoto, S., Ono, T., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  Genes Cells 14(2)
  
  Pages: 179-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390081
[Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy2009
- Author(s)
  Hosokawa N., Hara T., Kaizuka T., Kishi C., Takamura A., Miura Y., Iemura S. I., Natsume T., Takehana K., Yamada N., Guan J. L., Oshiro N., Mizushima N.
- Journal Title
  
  Mol. Biol. Cell (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] Activation of mTORC1 in two steps : Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.2009
- Author(s)
  Avruch, J., Long, X., Lin, Y., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., Oshiro, N., Kikkawa, U.
- Journal Title
  
  Biochem.Soc.Trans. 37(1)
  
  Pages: 223-226
- Data Source
  KAKENHI-PROJECT-20390081
[Journal Article] AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.2008
- Author(s)
  Miyamoto, T., Oshiro, N., Yoshino, K., Nakashima, A., Eguchi, S., Takahashi, M., Ono, Y., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  J.Biol.Chem. 283(7)
  
  Pages: 4430-4438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390081
[Journal Article] AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus2008
- Author(s)
  Miyamoto T., Oshiro N., Yoshino K., Nakashima A., Eguchi S., Takahashi M., Ono Y., Kikkawa U., Yonezawa K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 4430-4438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 12007
- Author(s)
  Oshiro, N.
- Journal Title
  
  J. Biol. Chem. 282・28
  
  Pages: 20329-20339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] The proline-Rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mTOR complex 12007
- Author(s)
  Oshiro, N., Takahashi, R., Yoshino, K., Tanimura, K., Nakashima, A., Eguchi, S., Miyamoto, T., Hara, K., Takehana, K., Avruch, J., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  J. Biol. Chem. 282(in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex2007
- Author(s)
  Nakashima A., Yoshino K., Miyamoto T., Eguchi S., Oshiro N., Kikkawa U., Yonezawa K.
- Journal Title
  
  Biochem Biophys Res Commun 361
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] The proline-Rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mTOR complex 12007
- Author(s)
  Oshiro, N.
- Journal Title
  
  J. Biol. Chem. 282(印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 12007
- Author(s)
  Oshiro N., Takahashi R., Yoshino K., Tanimura K., Nakashima A., Eguchi S., Miyamoto T., Hara K., Takehana K., Avruch J., Kikkawa U., Yonezawa K.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 20329-20339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790213
[Journal Article] Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell size2006
- Author(s)
  Eguchi, S., Tokunaga, C., Hidayat, S., Oshiro, N., Yoshino, K., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  Genes Cells 11 (7)
  
  Pages: 757-766
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin2006
- Author(s)
  Ohji, G., Hidayat, S., Nakashima, A., Tokunaga, C., Oshiro, N., Yoshino, K., Yokono, K., Kikkawa, U., Yonezawa, K.
- Journal Title
  
  J. Biochem. 139 (1)
  
  Pages: 129-135
- NAID
  10018848648
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Phosphorylation and up-regulation of diacylglycerol kinase y via its interaction with protein kinase Cy2006
- Author(s)
  Yamaguchi, Y., Shirai, Y., Matsubara, T., Sanse, K., Kuriyama, M., Oshiro, N., Yoshino, K., Yonezawa, K., Ono, Y., Saito, N.
- Journal Title
  
  J. Biol. Chem. 281 (42)
  
  Pages: 31627-31637
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization2005
- Author(s)
  Sakakibara, K., Sato, K., Yoshino, K., Oshiro, N., Hirahara, S., Hasan, A.K.M.M., Iwasaki, T., Ueda, Y., Iwao, Y., Yonezawa, K, Fukami, Y.
- Journal Title
  
  J. Biol. Chem. 280 (15)
  
  Pages: 15029-15037
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function2004
- Author(s)
  Oshiro, N.
- Journal Title
  
  Genes Cells 9(4)
  
  Pages: 359-366
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function2004
- Author(s)
  Oshiro, N., Yoshino, K., Hidayat, S., Tokunaga, C., Hara, K., Eguchi, S., Avruch, J., Yonezawa, K.
- Journal Title
  
  Genes Cells 9 (4)
  
  Pages: 359-366
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.2004
- Author(s)
  Oshiro, N.
- Journal Title
  
  Genes Cells 9・4
  
  Pages: 359-366
- Data Source
  KAKENHI-PROJECT-16390094
[Journal Article] mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells2004
- Author(s)
  Murakami, M., Ichisaka, T., Maeda, M., Oshiro, N., Hara, K., Edenhofer, F., Kiyama, H., Yonezawa, K., Yamanaka, S.
- Journal Title
  
  Mol. Cell Biol. 24 (15)
  
  Pages: 6710-6718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390094
[Presentation] The regulation of GFAT1 via AMPK signaling2008
- Author(s)
  Eguchi S., Oshiro N., Miyamoto T., Sasaki T., Yonezawa K., Kikkawa U.
- Organizer
  第60回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-19790213
[Presentation] The regulation of GFAT1 via AMPK signaling.2008
- Author(s)
  Eguchi, S., Oshiro, N., Miyamoto, T., Sasaki, T., Yonezawa, K., Kikkawa U.
- Organizer
  第60回日本細胞生物学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-20390081
[Presentation] AMPKの新規基質GFAT1の同定と機能解析2007
- Author(s)
  江口賢史, 大城紀子, 米澤一仁, 吉川潮
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学大会合同大会(BMB2007)
- Data Source
  KAKENHI-PROJECT-19790213
[Presentation] AMPK regulates the morphology of Golgi through the phosphorylation of GBF12007
- Author(s)
  宮本嵩史, 大城紀子, 米澤一仁, 吉川潮
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学大会合同大会(BMB2007)
- Data Source
  KAKENHI-PROJECT-19790213
[Presentation] Identification of PRAS40 (Proline-Rich Akt Substrate of 40 kDa) as a novel substrate of mTORC12007
- Author(s)
  大城紀子
- Organizer
  Biochemistry and Molecular Biology 2007
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19790213
[Presentation] Identification of PRAS40 (Proline-Rich Akt Substrate of 40 kDa) as a novel substrate of mTORC12007
- Author(s)
  大城紀子, 吉川潮
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学大会合同大会(BMB2007)
- Data Source
  KAKENHI-PROJECT-19790213

1. YOSHINO Ken-ichi (90280792)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. KIKKAWA Ushio (40150354)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
3. KAMADA Shinji (20243214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAKASHIMA Akio (70397818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 米澤一仁 (70283900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 徳永千春 (70335462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 鎌田振吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

OSHIRO Noriko 大城 紀子

Research Projects

Research Products

Co-Researchers

Regulation mechanisms of mTOR-mediated nutrient signaling by protein phosphatase PP2A

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of PRAS40, the novel substrate of mTOR that senses the nutritional environments and regulates cellular functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

mTORシグナルを介したがん抑制遺伝子TSCによる発がん機構の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミノ酸バランスを感知するシグナル伝達機構と核酸生合成の研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the Mammalian target of rapamycin in thrombocytepoiesis, wound healing, and hyperlipemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mammalian Tti1 and Tel2 are critical factors in mTOR complex assembly.2010

Author(s)

Journal Title

Data Source

[Journal Article] Activation of mTORC1 in two steps : Rheb-GTP activation of catalytic function and increased binding of substrates to raptor2009

Author(s)

Journal Title

Data Source

[Journal Article] AMP-activated protein kinase phosphorylates glutamine:fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity2009

Author(s)

Journal Title

Data Source

[Journal Article] AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity.2009

Author(s)

Journal Title

Data Source

[Journal Article] Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy2009

Author(s)

Journal Title

Data Source

[Journal Article] Activation of mTORC1 in two steps : Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.2009

Author(s)

Journal Title

Data Source

[Journal Article] AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.2008

Author(s)

Journal Title

Data Source

[Journal Article] AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus2008

Author(s)

Journal Title

Data Source

[Journal Article] The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 12007

Author(s)

Journal Title

Data Source

[Journal Article] The proline-Rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mTOR complex 12007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex2007

Author(s)

Journal Title

Data Source

[Journal Article] The proline-Rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mTOR complex 12007

OSHIRO Noriko 大城紀子