NARA Masayuki 奈良正之

Researcher Number	70374999
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 東北大学, 医学系研究科, 非常勤講師 2016 – 2017: 東北大学, 大学病院, 特任教授 2015: 東北大学, 大学病院, 教授 2014: 東北大学, 大学病院, 特任教授 2014: 東北大学, 病院, 特任教授 2013: 東北大学, 大学病院, 教授 2012: 東北大学, 大学病院, 准教授
Review Section/Research Field	Principal Investigator General internal medicine (including Psychosomatic medicine) Except Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator SF-8 / D-dimer / 血圧 / 東日本大震災 / 段ボール製ベッド / 総合医療 / 災害医療 Except Principal Investigator COPD増悪 / 気道粘膜下腺 / 気道分泌 … More / 過分泌 / 難治性喘息 / Toll様受容体 / パッチクランプ / 気道粘膜防御 / 呼吸器内科 / 粘液線毛輸送能 / 新鮮気道分泌液 / 増悪 / LABA / COPD / 酸性 / HCO3- / CFTR / 気道粘膜防御機構 / 重症喘息 / 微生物叢 / 一酸化窒素 / 電解質分泌 / アセチルコリン / LPS / Nitric oxide / Flagellin / 粘膜免疫 Less

Exploring the fragility of mucosal defense systems caused by an acquired dysregulation of airway secretion
- Principal Investigator
  
  Tamada Tsutomu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
Detection of specific antigens from lung microbiome causing a dysfunction of airway mucociliary transport and its regulation of those signaling in chronic inflammatory airway diseases
- Principal Investigator
  
  Tamada Tsutomu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
A study on the mechanisms of antigen-dependent potentiation in airway secretion via TLRs
- Principal Investigator
  
  TAMADA TSUTOMU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
The clinical utility of makeshift beds in the Great East Japan Earthquake sheltersPrincipal Investigator
- Principal Investigator
  
  NARA Masayuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Tohoku University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Effects of indacaterol on the LPS-evoked changes in fluid secretion rate and pH in swine tracheal membrane.2021
- Author(s)
  Aritake H, Tamada T, Murakami K, Gamo S, Nara M, Kazama I, Ichinose M and Sugiura H.
- Journal Title
  
  Pflügers Archiv
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08137
[Journal Article] The Clinical Features of Patients with Sarcoidosis and Malignant Diseases in Japan2021
- Author(s)
  Tamada T, Nara M, Murakami K, Gamo S, Aritake H, Shimizu M, Kazama I, Ichinose M and Sugiura H.
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 2 Pages: 209-216
- DOI
  10.2169/internalmedicine.5441-20
- NAID
  130007968940
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-01-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08137, KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-21K08148
[Journal Article] TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells2018
- Author(s)
  Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Okazaki T, Sugiura H, Ichinose M
- Journal Title
  
  Exp Physiol
  
  Volume: 103 Issue: 11 Pages: 1543-1559
- DOI
  10.1113/ep087221
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08484, KAKENHI-PROJECT-18K08137, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-16K15453
[Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy.2016
- Author(s)
  Numakura T, Tamada T, Nara M, Muramatsu S, Murakami K, Kikuchi T, Kobayashi M, Muroi M, Okazaki T, Takagi S, Eishi Y, Ichinose M.
- Journal Title
  
  BMC Pulm Med.
  
  Volume: 16 Issue: 1 Pages: 30-30
- DOI
  10.1186/s12890-016-0193-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15316, KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-15K09207
[Journal Article] A Case of Acute Sarcoidosis with Fever and Polyarthralgia2016
- Author(s)
  小野寺克洋、玉田　勉、村松聡士、村上康司、奈良正之、小松理世、小林　誠、山田充啓、杉浦久敏、一ノ瀬正和
- Journal Title
  
  Nihon Naika Gakkai Zasshi
  
  Volume: 105 Issue: 3 Pages: 540-546
- DOI
  10.2169/naika.105.540
- NAID
  130005439474
- ISSN
  0021-5384, 1883-2083
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09207
[Journal Article] 気管・気管支軟化症2015
- Author(s)
  奈良正之、玉田　勉
- Journal Title
  
  呼吸
  
  Volume: 33 Pages: 304-308
- Data Source
  KAKENHI-PROJECT-15K09207
[Journal Article] 解説【基礎】　TLRと気道分泌2014
- Author(s)
  玉田　勉、奈良正之、村上康司、村松聡士、一ノ瀬正和
- Journal Title
  
  呼吸
  
  Volume: 33 Pages: 971-981
- Data Source
  KAKENHI-PROJECT-24591150
[Journal Article] The clinical utility of makeshift beds in disaster shelters2013
- Author(s)
  Nara M, Ueda S, Aoki M, Tamada T, Yamaguchi T, Hongo M.
- Journal Title
  
  Disaster Med Public Health Preparedness
  
  Volume: 7 Issue: 6 Pages: 573-577
- DOI
  10.1017/dmp.2013.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659342
[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands.2013
- Author(s)
  Muramatsu S, Tamada T, Nara M, Murakami K, Kikuchi T, Kanehira M, Maruyama Y, Ebina M, Nukiwa T, Ichinose M.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 305 Issue: 11 Pages: L819-L830
- DOI
  10.1152/ajplung.00053.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390219, KAKENHI-PROJECT-24591150, KAKENHI-PROJECT-24659399
[Presentation] 悪性リンパ腫に対するオビヌツズマブ併用療法により肺サルコイドーシスが増悪した1例2020
- Author(s)
  村上康司、玉田　勉、奈良正之、福原規子、榊原智博、杉浦久敏
- Organizer
  第40回日本サルコイドーシス／肉芽腫性疾患学会総会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] サルコイドーシスの血漿および尿中におけるリゾリン脂質産生酵素の解析2020
- Author(s)
  村上康司、玉田　勉、三枝大輔、奈良正之、宮内栄作、有竹秀美、蒲生俊一、矢富　裕、一ノ瀬正和
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] 新鮮ブタ気道分泌液pHに対する長時間作用性β2刺激薬（LABA）の影響2020
- Author(s)
  有竹秀美、玉田　勉、村上康司、蒲生俊一、奈良正之、杉浦久敏、一ノ瀬正和
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] Long-acting bronchodilators improve lipopolysaccharide-induced swine airway hypersecretion as well as the abnormal acidification in pH.2020
- Author(s)
  Aritake H, Tamada T, Murakami K, Gamo S, Nara M, Sugiura H and Ichinose M.
- Organizer
  European Respiratory Society Virtual 2020 Annual Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] ヒトCOPD気道におけるToll様受容体 (TLR) 7の発現低下と気道分泌に与える影響の検討2019
- Author(s)
  蒲生俊一、玉田勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] Effects of long-acting bronchodilators on airway mucus quantity and quality2019
- Author(s)
  Aritake H, Tamada T, Murakami K, Gamo S, Nara M, Sugiura H and Ichinose M.
- Organizer
  ATS International Conference in Dallas TX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] Recent trends of clinical features of sarcoidosis in Japan.2019
- Author(s)
  Murakami K, Tamada T, Gamo S, Nara M, Aritake H and Ichinose M
- Organizer
  International Conference on Sarcoidosis and Interstitial Lung Diseases 2019 in Yokohama
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] 長時間作用型気管支拡張薬が新鮮気道分泌液の特性に与える影響の検討2019
- Author(s)
  有竹秀美、玉田勉、村上康司、蒲生俊一、奈良正之、杉浦久敏、一ノ瀬正和
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] The clinical features of malignant diseases in Japanese patients with sarcoidosis.2019
- Author(s)
  Aritake H, Tamada T, Murakami K, Nara M, Gamo S, Sugiura H and Ichinose M
- Organizer
  International Conference on Sarcoidosis and Interstitial Lung Diseases 2019 in Yokohama.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] TLR7刺激によるSarco/Endoplasmic Reticulum Calcium ATPase(SERCA) 作用亢進についての検討2018
- Author(s)
  蒲生俊一、玉田勉、村上康司、有竹秀美、村松聡士、奈良正之、杉浦久敏、一ノ瀬正和
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] COPDに対する気管支拡張薬が気道被覆液の質的特性に及ぼす影響2018
- Author(s)
  有竹秀美、玉田勉、村上康司、蒲生俊一、村松聡士、奈良正之、一ノ瀬正和
- Organizer
  第58回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K08137
[Presentation] Upregulation of Ca2+-ATPase by TLR7 Decreases Electrolyte Secretion from Airway Submucosal Gland Cells2017
- Author(s)
  Gamo S, Tamada T, Murakami K, Muramatsu S, Aritake H, Nara M, Kazama I, Sugiura H, Ichinose M.
- Organizer
  2017 ATS International Conference in Washington DC
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] TLR7リガンドによる気道分泌抑制作用の細胞内機序について2017
- Author(s)
  蒲生俊一、玉田勉、村上康司、村松聡士、有竹秀美、奈良正之、風間逸郎、杉浦久敏、一ノ瀬正和
- Organizer
  第57回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] 組織学的に診断された卵管サルコイドーシスの1例2016
- Author(s)
  村松聡士、玉田勉、奈良正之、村上康司、蒲生俊一、丸山和一、久野貴司、立花眞仁、杉浦久敏、八重樫伸生、一ノ瀬正和
- Organizer
  第36回日本サルコイドーシス/肉芽腫性疾患学会総会
- Place of Presentation
  東京、東京医科歯科大学　M＆Dタワー2階　鈴木章夫記念講堂
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] メタボロミクス解析を用いたサルコイドーシス新規バイオマーカーの検索2016
- Author(s)
  村松聡士, 玉田　勉, 三枝大輔, 奈良正之, 蒲生俊一, 村上康司, 杉浦久敏, 一ノ瀬正和
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] Ｔoll like receptor 7 regulates the electrolytes secretion from airway submucosal gland.2016
- Author(s)
  Gamo S, Muramatsu S, Murakami K, Tamada T, Nara M, Sugiura H, Ichinose M.
- Organizer
  2016 ATS International Conference
- Place of Presentation
  San Francisco, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] TLR7の気道粘膜下腺細胞での発現と分泌機能への影響2016
- Author(s)
  蒲生俊一、玉田勉、村松聡士、奈良正之、村上康司、杉浦久敏、一ノ瀬正和
- Organizer
  第56回日本呼吸器学会学術講演会
- Place of Presentation
  京都、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] 当院科外来で全身性サルコイドーシスのフォロー中、寛解後に増悪を認めた症例の臨床的検討2016
- Author(s)
  蒲生俊一、玉田勉、村松聡士、村上康司、奈良正之、杉浦久敏、一ノ瀬正和
- Organizer
  第36回日本サルコイドーシス/肉芽腫性疾患学会総会
- Place of Presentation
  東京、東京医科歯科大学　M＆Dタワー2階　鈴木章夫記念講堂
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] 気道分泌調整因子としてのTLRリガンドの細胞内カルシウム濃度への影響2015
- Author(s)
  蒲生俊一、玉田　勉、村松聡士、村上康司、奈良正之、菊地利明、一ノ瀬正和
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] 診断基準改訂前後の当科におけるサルコイドーシスと悪性腫瘍の合併例の検討2015
- Author(s)
  村松聡士、玉田　勉、奈良正之、村上康司、蒲生俊一、菊地利明、一ノ瀬正和
- Organizer
  第55回日本呼吸器学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] Effects of TLR ligands on the intracellular calcium signaling in tracheal submucosal gland acinar cells.2015
- Author(s)
  Muramatsu, S., T. Tamada, M. Nara, S. Gamow, K. Murakami, T. Kikuchi and M. Ichinose.
- Organizer
  ATS 2015 International Conference
- Place of Presentation
  Denver, CO, USA
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09207
[Presentation] 気道粘膜下腺細胞からのCl-およびHCO3-分泌調節におけるインダカテロールの関与2013
- Author(s)
  村上康司、玉田　勉、奈良正之、村松聡士、菊地利明、海老名雅仁、一ノ瀬正和
- Organizer
  第53回日本呼吸器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591150
[Presentation] A switching effect of indacaterol on anion secretions from Cl- to HCO3- in airway submucosal gland cells.2013
- Author(s)
  Murakami, K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. M. Ebina and M. Ichinose.
- Organizer
  ATS 2013 International Conference
- Place of Presentation
  フィラデルフィア、米国
- Data Source
  KAKENHI-PROJECT-24591150
[Presentation] Flagellin/TLR5シグナルの気道分泌に対する影響2013
- Author(s)
  村松聡士、玉田　勉、奈良正之、村上康司、菊地利明、兼平雅彦、海老名雅仁、一ノ瀬正和
- Organizer
  第53回日本呼吸器学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24591150
[Presentation] TLR 4 signaling potentiates airway secretion from the swine submucosal gland via NO/cGMP/cGK pathway.2012
- Author(s)
  Murakami, K., T. Tamada, M. Nara, S. Muramatsu, T. Kikuchi, M. Kanehira and M. Ebina.
- Organizer
  European Respiratory Society Vienna 2012 Annual Congress
- Place of Presentation
  ウィーン、オーストリア
- Data Source
  KAKENHI-PROJECT-24591150
[Presentation] 東日本大震災における避難所での段ボール製ベッドの有用性の検討2012
- Author(s)
  奈良正之、植田信策、青木正志、玉田勉、筒井美穂、金村政輝、本郷道夫
- Organizer
  第5回日本病院総合診療医学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-24659342
[Presentation] Flagellin potentiates the Ca2+-dependent electrolytes secretion from airway submucosal gland in a TLR4-independent, TLR5-dependent and cGK-dependent manner.2012
- Author(s)
  Muramatsu, S., T. Tamada, M. Nara, K. Murakami and M. Ebina
- Organizer
  European Respiratory Society Vienna 2012 Annual Congress
- Place of Presentation
  ウィーン、オーストリア
- Data Source
  KAKENHI-PROJECT-24591150
[Presentation] TLR7,8リガンドの気道粘膜下腺細胞への影響
- Author(s)
  村松聡士、玉田　勉、奈良正之、村上康司、菊地利明、一ノ瀬正和
- Organizer
  第54回日本呼吸器学会学術講演会
- Place of Presentation
  大阪国際会議場（大阪市）
- Year and Date
  2014-04-25 – 2014-04-27
- Data Source
  KAKENHI-PROJECT-24591150

1. TAMADA TSUTOMU (80396473)

# of Collaborated Projects: 4 results

# of Collaborated Products: 32 results
2. AOKI Masashi (70302148)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. FUKUDO Shin (80199249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 村松聡士 (30732549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. 村上康司 (70633725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
6. 菊地利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 風間逸郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NARA Masayuki 奈良 正之

Research Projects

Research Products

Co-Researchers

Exploring the fragility of mucosal defense systems caused by an acquired dysregulation of airway secretion

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Detection of specific antigens from lung microbiome causing a dysfunction of airway mucociliary transport and its regulation of those signaling in chronic inflammatory airway diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the mechanisms of antigen-dependent potentiation in airway secretion via TLRs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The clinical utility of makeshift beds in the Great East Japan Earthquake sheltersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of indacaterol on the LPS-evoked changes in fluid secretion rate and pH in swine tracheal membrane.2021

Author(s)

Journal Title

Data Source

[Journal Article] The Clinical Features of Patients with Sarcoidosis and Malignant Diseases in Japan2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] TLR7 agonist attenuates acetylcholine-induced, Ca2+ -dependent ionic currents in swine tracheal submucosal gland cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Case of Acute Sarcoidosis with Fever and Polyarthralgia2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] 気管・気管支軟化症2015

Author(s)

Journal Title

Data Source

[Journal Article] 解説【基礎】 TLRと気道分泌2014

Author(s)

Journal Title

Data Source

[Journal Article] The clinical utility of makeshift beds in disaster shelters2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] 悪性リンパ腫に対するオビヌツズマブ併用療法により肺サルコイドーシスが増悪した1例2020

Author(s)

Organizer

NARA Masayuki 奈良正之

[Journal Article] 解説【基礎】　TLRと気道分泌2014