Isayama Hiroyuki 伊佐山浩通

… Alternative Names

ISAYAMA Hiroyuki 伊佐山浩通

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Researcher Number	70376458
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 順天堂大学, 医学部, 教授 2013 – 2018: 東京大学, 医学部附属病院, 准教授 2012: 東京大学, 医学部附属病院, 講師 2010 – 2011: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Tumor biology / Tumor biology Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Gastroenterology / Tumor biology
Keywords	Principal Investigator CXCR2 / 膵癌 / 線維芽細胞 / 腫瘍間質相互作用 / 微小環境 / ケモカイン / CCR2 / 微小環 / 膵発癌モデル / ノックアウトマウス … More / ケモカインシグナル / CXCケモカイン / CCケモカイン / デスモプラジア / 遺伝子改変マウス / CTGF / マクロファージ … More Except Principal Investigator 膵癌 / 神経浸潤 / 膵臓癌 / ポリフェノール / Gemcitabine / 転移 / 浸潤 / IL-13Rα2 / EUS-FNA / 抗癌剤抵抗性 / IL13Ra2 / 化学療法抵抗性 / 代謝経路 / 術前化学療法 / 超音波内視鏡 / EUS-FNB / HDAC inhibitor / Histone修飾 / IL-13 receptor alpha2 / エピジェネティクス / epigenetics / 動物モデル / 浸潤転移 / 予測因子 / gemcitabine / 化学療法 / バイオマーカー / 抗癌剤効果予測 / 予後 / 浸潤・転移 / 緑茶ポリフェノール / IL-13Ra2 / エピジェネテイクス / 胆道癌 / 胆管がん / 胆管癌 / 細胞接着 / acinar-ductal metaplasia / BMPII型受容体 / BMP / BMPシグナル / ＰＳＣＡ / PSCA Less

Elucidation and clinical application of mechanism for chemotherapy resistance enhanced by IL-13Ralpha2 in pancreatic cancer.
- Principal Investigator
  
  藤澤聡郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
An Efficacy of polyphenols for Il13Ra2-positive advanced pancreatic cancer
- Principal Investigator
  
  FUJISAWA Toshio
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Juntendo University
Impact of chemokine signals in the tumor microenvironment of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  ISAYAMA Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Juntendo University
  The University of Tokyo
Roles of BMP signaling in pancreatic cancer initiation and progression using a genetically-engineered mouse model
- Principal Investigator
  
  Ijichi Hideaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Analysys of epigenetic system related to the development of cholangiocarcinoma using 3D culture system.
- Principal Investigator
  
  MATSUBARA SABURO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Saitama Medical University
  The University of Tokyo
Fibloblast response to the tumor in the desmoplasia involved in the malignant potential of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  ISAYAMA Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Functional analysis of pancreatic cancer-specific antigen highly expressed throughout the disease stage
- Principal Investigator
  
  IJICHI Hideaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  The University of Tokyo
Targeting tumor microenvironment as a novel therapeutic strategy for pancreatic cancer using a genetically-engineered mouse modelPrincipal Investigator
- Principal Investigator
  
  ISAYAMA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Dedicated Echoendoscope for Interventional Endoscopic Ultrasound: Comparison with a Conventional Echoendoscope2024
- Author(s)
  Fujisawa Toshio、Ishii Shigeto、Nakai Yousuke、Kogure Hirofumi、Tomishima Ko、Takasaki Yusuke、Ito Koichi、Takahashi Sho、Suzuki Akinori、Isayama Hiroyuki
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 13 Issue: 10 Pages: 2840-2840
- DOI
  10.3390/jcm13102840
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07227
[Journal Article] STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: an open label, phase I/IIa trial2023
- Author(s)
  Fujisawa Toshio、Tsuchiya Takayoshi、Kato Motohiko、Mizuide Masafumi、Takakura Kazuki、Nishimura Makoto、Kutsumi Hiromu、Matsuda Yoko、Arai Tomio、Ryozawa Shomei、Itoi Takao、Isayama Hiroyuki、Saya Hideyuki、Yahagi Naohisa
- Journal Title
  
  eClinicalMedicine
  
  Volume: 55 Pages: 101731-101731
- DOI
  10.1016/j.eclinm.2022.101731
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07227
[Journal Article] Pancreatic Adenocarcinoma With Strong Expression of Interleukin-13 Receptor α2 Shows a Poor Response to Gemcitabine-Based Chemotherapy.2022
- Author(s)
  Tomishima K, Fujisawa T, Fukumura Y, Ushio M, Fukuma T, Takahashi S, Takasaki Y, Suzuki A, Ito K, Ishii S, Yao T, Nagahara A, Isayama H.
- Journal Title
  
  Pancreas
  
  Volume: 51 Issue: 9 Pages: 1133-1139
- DOI
  10.1097/mpa.0000000000002151
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06912, KAKENHI-PROJECT-21K07227, KAKENHI-PROJECT-18K07332
[Journal Article] IL-13Rα2 Is a Biomarker of Diagnosis and Therapeutic Response in Human Pancreatic Cancer2021
- Author(s)
  Fujisawa T, Joshi BH, Takahashi S, Takasaki Y, Suzuki A, Ito K, Ochiai K, Tomishima K, Ishii S, Puri RK, Isayama H.
- Journal Title
  
  Diagnostics
  
  Volume: 11 Issue: 7 Pages: 1140-1140
- DOI
  10.3390/diagnostics11071140
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07332, KAKENHI-PROJECT-21K07227
[Journal Article] Immunotherapy for Pancreatic Cancer2020
- Author(s)
  Toshio Fujisawa, Hiroyuki Isayama
- Journal Title
  
  Juntendo Medical Journal
  
  Volume: 66 Issue: 3 Pages: 238-244
- DOI
  10.14789/jmj.2020.66.JMJ20-LN02
- NAID
  130007867030
- ISSN
  2187-9737, 2188-2126
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07332
[Journal Article] A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and Its Association With Poor Prognosis of Patients With Pancreatic Ductal Adenocarcinoma2020
- Author(s)
  Toshio Fujisawa, Takeshi Shimamura, Kaku Goto, Ryo Nakagawa, Ryosuke Muroyama, Yoshinori Ino, Hajime Horiuchi, Itaru Endo, Shin Maeda, Yasushi Harihara, Atsushi Nakajima,, Nobuyuki Matsuhashi, Naoya Kato, Hiroyuki Isayama, Ankit Puri, Akiko Suzuki, Ian Bellayr, Pamela Leland, Bharat H Joshi, Raj K Puri
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 5 Pages: 1294-1294
- DOI
  10.3390/cancers12051294
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07332
[Journal Article] Blocking CXCLs?CXCR2 axis in tumor?stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment2019
- Author(s)
  Sano Makoto、Ijichi Hideaki、Takahashi Ryota、Miyabayashi Koji、Fujiwara Hiroaki、Yamada Tomoharu、Kato Hiroyuki、Nakatsuka Takuma、Tanaka Yasuo、Tateishi Keisuke、Morishita Yasuyuki、Moses Harold L.、Isayama Hiroyuki、Koike Kazuhiko
- Journal Title
  
  Oncogenesis
  
  Volume: 8 Issue: 2 Pages: 8-8
- DOI
  10.1038/s41389-018-0117-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-17K09454, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-19K08435, KAKENHI-PROJECT-16K07109
[Journal Article] Comparison of early and delayed EUS-guided drainage of pancreatic fluid collection2018
- Author(s)
  Chantarojanasiri Tanyaporn、Yamamoto Natsuyo、Nakai Yousuke、Saito Tomotaka、Saito Kei、Hakuta Ryunosuke、Ishigaki Kazunaga、Takeda Tsuyoshi、Uchino Rie、Takahara Naminatsu、Mizuno Suguru、Kogure Hirofumi、Matsubara Saburo、Tada Minoru、Isayama Hiroyuki、Koike Kazuhiko
- Journal Title
  
  Endoscopy International Open
  
  Volume: 06 Issue: 12 Pages: E1398-E1405
- DOI
  10.1055/a-0751-2698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09391
[Journal Article] A phase II trial of gemcitabine, S-1 and LV combination (GSL) therapy in patients with advanced pancreatic cancer2018
- Author(s)
  Saito K、Isayama H、Nakai Y、Takahara N、Ishigaki K、Takeda T、Hakuta R、Saito T、Uchino R、Kishikawa T、Hamada T、Mizuno S、Sasaki T、Kogure H、Matsubara S、Yamamoto N、Ijichi H、Tateishi K、Tada M、Koike K
- Journal Title
  
  Investigational New Drugs
  
  Volume: 37 Issue: 2 Pages: 338-344
- DOI
  10.1007/s10637-018-0691-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-16K09391
[Journal Article] A Multicenter Open-Label Randomized Controlled Trial of Pancreatic Enzyme Replacement Therapy in Unresectable Pancreatic Cancer2018
- Author(s)
  Saito T、Nakai Y、Isayama H、Hirano K、Ishigaki K、Hakuta R、Takeda T、Saito K、Umefune G、Akiyama Dai、Watanabe Takeo、Takagi Kaoru、Takahara Naminatsu、Hamada T、Uchino R、Mizuno S、Mouri D、Yagioka H、Kogure H、Togawa O、Matsubara S、Ito Y、Yamamoto N、Tada M、Koike K
- Journal Title
  
  Pancreas
  
  Volume: 47 Issue: 7 Pages: 800-806
- DOI
  10.1097/mpa.0000000000001079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09391
[Presentation] 膵癌抗癌剤治療におけるIL-13 receptorα2 発現による効果予測と感受性低下機序の解明2023
- Author(s)
  藤澤聡郎, 冨嶋享, 伊佐山浩通.
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] 膵癌におけるIL-13 receptorα2発現とジェムシタビン感受性の関連性2023
- Author(s)
  藤澤　聡郎、冨嶋　享、伊佐山　浩通
- Organizer
  第109回日本消化器病学会総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌抗癌剤治療におけるIL-13 receptorα2 発現による効果予測と感受性低下機序の解明2023
- Author(s)
  藤澤聡郎, 冨嶋享, 伊佐山浩通.
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] Pancreatic Adenocarcinoma with Strong Expression of IL-13Rα2 Shows a Poor Response to Gemcitabine-based Chemotherapy2023
- Author(s)
  Ko Tomishima, Toshio Fujisawa, Yuki Fukumura, Hiroto Ota, Daishi Kabemura, Mako Ushio, Taito Fukuma, Sho Takahashi, Yusuke Takasaki, Akinori Suzuki, Koichi Ito, Shigeto Ishii, Takashi Yao, Hiroyuki Isayama
- Organizer
  United European Gastroenterology Week 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌化学療法効果予測におけるIL-13 receptor α2のバイオマーカーとしての役割2023
- Author(s)
  藤澤　聡郎、冨嶋　享、福村　由紀、齋浦　明夫、伊佐山　浩通
- Organizer
  第54回日本膵臓学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] PANCREATIC ADENOCARCINOMA WITH STRONG EXPRESSION OF IL-13R?2 SHOWS A POOR RESPONSE TO GEMCITABINE-BASED CHEMOTHERAPY.2022
- Author(s)
  Ko Tomishima, Toshio Fujisawa, Hiroyuki Isayama
- Organizer
  United-European Gastrointestinal Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌EUS-FNA検体で評価し得たIL-13 receptor&alpha2発現と化学療法効果について.2022
- Author(s)
  冨嶋享, 藤澤聡郎, 伊佐山浩通, 福村由紀
- Organizer
  第103回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌EUS-FNA検体で評価し得たIL-13 receptor a2発現と化学療法効果について2022
- Author(s)
  冨嶋　享、藤澤　聡郎、伊佐山　浩通、福村　由紀
- Organizer
  第103回　日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] PANCREATIC ADENOCARCINOMA WITH STRONG EXPRESSION OF IL-13RA2 SHOWS A POOR RESPONSE TO GEMCITABINE-BASED CHEMOTHERAPY.2022
- Author(s)
  Ko Tomishima, Toshio Fujisawa, Hiroyuki Isayama
- Organizer
  United-European Gastrointestinal Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] 膵癌EUS-FNA検体で評価し得たIL-13 receptor&alpha2発現と化学療法効果について.2022
- Author(s)
  冨嶋享, 藤澤聡郎, 伊佐山浩通, 福村由紀.
- Organizer
  第103回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] 膵癌の化学療法選択においてIL-13 receptorα2発現の示す意義.2022
- Author(s)
  冨嶋享, 藤澤聡郎, 伊佐山浩通
- Organizer
  U45消化器疾患イノベーションカンファレンス ~サイエンスでつながる次世代の会~
- Invited
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌の化学療法の選択においてIL-13 receptor a2発現の示す意義2022
- Author(s)
  冨嶋　享、藤澤　聡郎、伊佐山　浩通
- Organizer
  第108回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌の化学療法選択においてIL-13 receptorα2発現の示す意義.2022
- Author(s)
  冨嶋享, 藤澤聡郎, 伊佐山浩通.
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] 膵癌の化学療法の選択においてIL-13 receptor a2発現の示す意義2022
- Author(s)
  冨嶋　享、藤澤　聡郎、伊佐山　浩通
- Organizer
  第108回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] 膵癌の化学療法選択においてIL-13 receptorα2発現の示す意義.2022
- Author(s)
  冨嶋享, 藤澤聡郎, 伊佐山浩通.
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07227
[Presentation] 膵癌EUS-FNA検体で評価し得たIL-13 receptor a2発現と化学療法効果について2022
- Author(s)
  冨嶋　享、藤澤　聡郎、伊佐山　浩通、福村　由紀
- Organizer
  第103回　日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-18K07332
[Presentation] Blocking CXCLs-CXCR2 axis contributes to the survival in a mouse model of pancreatic ductal adenocarcinoma via reduced invasion and a shift of immune-inflammatory microenvironment2018
- Author(s)
  Sano Makoto, Ijichi Hideaki , Takahashi Ryota, Miyabayashi Koji, Tateishi Keisuke, Isayama Hiroyuki, Harold L Moses, Koike Kazuhiko
- Organizer
  AACR Special Conference: Pancreatic Cancer 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07109
[Presentation] 膵癌におけるCXCLs/CXCR2阻害は癌免疫環境を修飾し生存に寄与する2018
- Author(s)
  佐野誠、伊地知秀明、立石敬介、多田稔、伊佐山浩通、小池和彦
- Organizer
  第49回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-16K07109

1. IJICHI Hideaki (70463841)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. FUJISAWA Toshio (50627346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. SANO Makoto

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. MATSUBARA SABURO (40750550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 立石敬介 (20396948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Miyabayashi Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJIWARA hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中井陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 水野卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 福村由紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Isayama Hiroyuki 伊佐山 浩通

ISAYAMA Hiroyuki 伊佐山 浩通

Research Projects

Research Products

Co-Researchers

Elucidation and clinical application of mechanism for chemotherapy resistance enhanced by IL-13Ralpha2 in pancreatic cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An Efficacy of polyphenols for Il13Ra2-positive advanced pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of chemokine signals in the tumor microenvironment of pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of BMP signaling in pancreatic cancer initiation and progression using a genetically-engineered mouse model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysys of epigenetic system related to the development of cholangiocarcinoma using 3D culture system.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fibloblast response to the tumor in the desmoplasia involved in the malignant potential of pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of pancreatic cancer-specific antigen highly expressed throughout the disease stage

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting tumor microenvironment as a novel therapeutic strategy for pancreatic cancer using a genetically-engineered mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dedicated Echoendoscope for Interventional Endoscopic Ultrasound: Comparison with a Conventional Echoendoscope2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STNM01, the RNA oligonucleotide targeting carbohydrate sulfotransferase 15, as second-line therapy for chemotherapy-refractory patients with unresectable pancreatic cancer: an open label, phase I/IIa trial2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pancreatic Adenocarcinoma With Strong Expression of Interleukin-13 Receptor α2 Shows a Poor Response to Gemcitabine-Based Chemotherapy.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IL-13Rα2 Is a Biomarker of Diagnosis and Therapeutic Response in Human Pancreatic Cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunotherapy for Pancreatic Cancer2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Isayama Hiroyuki 伊佐山浩通

ISAYAMA Hiroyuki 伊佐山浩通