TAKAHASHI Toshiaki 高橋俊昭

Researcher Number	70377191
External Links
Affiliation (based on the past Project Information) *help	2011 – 2013: 新潟大学, 脳研究所, 非常勤講師 2007 – 2010: Niigata University, 医歯学系, 助教 2005 – 2006: 新潟大学, 医歯学系, 助手
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator ポリグルタミン病 / 神経変性 / 重合体 / FRET / オリゴマー / SDD-AGE / C.elegans / DRPLA / oligomer / polyglutamine … More / シリンダー構造 / 細胞膜 / モノマー / 細胞内カルシウム濃度 / 封入体 / ダイマー / PA-GFP / プロテオミクス解析 / RA-GFP / 核外移行遅延 / 核内蓄積 / 分解遅延 … More Except Principal Investigator 二量体 / アプラタキシン / DNA修復機構 / 神経変性疾患 / DNA損傷修復 / 脊髄小脳変性症 Less

Polyglutamine oligomers in human brain play a crucial role in the pathogenesis of polyglutamine diseases.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Study on a molecular basis for the cytotoxicity induced by polyglutamine proteins.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Impairment of quality control system for nucleic acids and neurodegenerative disorders.
- Principal Investigator
  
  ONODERA Osamu
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Study on the toxicity initiated by polyglutamine oligomersPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
ポリグルタミン鎖の長さ依存性分解代謝遅延および細胞内局在性の解明Principal Investigator
- Principal Investigator
  
  高橋俊昭
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] Research Advances in Spinocerebellar Degeneration and Spastic Paraplegia 20082008
- Author(s)
  高橋俊昭
- Total Pages
  18
- Publisher
  RESEARCH SIGNPOST
- Data Source
  KAKENHI-PROJECT-19790602
[Book] Research Advances in Spinocerebellar Degeneration and Spastic Paraplegia 2008[Polyglutamine disease:Theraputic strategy depends on cytotoxic structure and dysfunction.]2008
- Author(s)
  T Takahashi, S Kikuchi, O Onodera
- Publisher
  RESEARCH SIGNPOST
- Data Source
  KAKENHI-PROJECT-19790602
[Book] 神経研究の進歩(特集脊髄小脳変性症研究の最近の進歩).2006
- Author(s)
  高橋俊昭, 小野寺理(共著)
- Total Pages
  7
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17790573
[Journal Article] Polyglutamine diseases : where does toxicity come from? what is toxicity? where are we going?2010
- Author(s)
  Takahashi T, Katada S, Onodera O., (全3名中、1番)
- Journal Title
  
  J Mol Cell Biol.
  
  Volume: 2(4) Pages: 180-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790837
[Journal Article] Polyglutamine diseases : where does toxicity come from ? what is toxicity ? where are we going2010
- Author(s)
  Takahashi T, Katada S, Onodera O.
- Journal Title
  
  JMolCellBiol. 2(4)
  
  Pages: 180-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790837
[Journal Article] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008
- Author(s)
  Toshiaki Takahashi, 他
- Journal Title
  
  Human Molecular Genetics 17(3)
  
  Pages: 345-356
- Data Source
  KAKENHI-PROJECT-19790602
[Journal Article] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008
- Author(s)
  Takahashi T, Kikuchi S, Katada S, Nagai Y, Nishizawa M, Onodera O
- Journal Title
  
  Hum Mol Genet 17(3)
  
  Pages: 345-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790602
[Journal Article] Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends2007
- Author(s)
  Takahashi T, Tada M, Igarashi S, Koyama A, Date H, Yokoseki A, Shiga A, Yoshida Y, Tsuji S, Nishizawa M, Onodera O
- Journal Title
  
  Nucleic Acids Res 35(11)
  
  Pages: 3797-809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390236
[Presentation] ヒト疾患脳におけるポリグルタミン病重合体の検出2011
- Author(s)
  高橋俊昭
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-23591235
[Presentation] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2010
- Author(s)
  高橋俊昭
- Organizer
  第5回日本分子イメージング学会学術大会
- Place of Presentation
  滋賀県大津市(招待講演)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21790837
[Presentation] PML発現賦活によるポリグルタミン病の治療検討2010
- Author(s)
  高橋俊昭, 日高梓, 堅田慎一, 小野寺理, 西澤正豊
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京都千代田区
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21790837
[Presentation] ポリグルタミン蛋白の立体構造と重合様式の検討2009
- Author(s)
  高橋俊昭, 堅田慎一, 小野寺理, 西澤正豊
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-21790837
[Presentation] Aprataxinは神経細胞においてDNA単鎖切断損傷修復に関与する2008
- Author(s)
  他田正義, 佐藤達哉, 横関明男, 小山哲秀, 志賀篤, 高橋哲哉, 小宅睦郎, 五十嵐修一, 佐藤俊哉, 辻省次, 西澤正豊, 小野寺理
- Organizer
  日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19390236
[Presentation] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008
- Author(s)
  高橋俊昭
- Organizer
  The American Society for Cell Biology 48^<th> meeting
- Place of Presentation
  アメリカ合衆国San Francisco, Califbrnia
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-19790602
[Presentation] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008
- Author(s)
  高橋俊昭
- Organizer
  The American Society for Cell Biology 48th meeting
- Place of Presentation
  アメリカ合衆国サンフランシスコ
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-19790602
[Presentation] 可溶性ポリグルタミンオリゴマーは細胞毒性を惹起する(シンポジウムロ演)2007
- Author(s)
  高橋俊昭
- Organizer
  Neuro2007(合同学会;日本神経科学大会、日本神経化学会大会、日本神経回路学会大会)
- Place of Presentation
  横浜市
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-19790602
[Presentation] EAOHの病因蛋白aprataxinは校正機能を有する3'-5'exonucleaseである2007
- Author(s)
  他田正義, 横関明男, 高橋哲哉, 五十嵐修一, 西澤正豊, 小野寺理
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-19390236
[Presentation] 可溶性ポリグルタミンオリゴマーは細胞毒性を惹起する2007
- Author(s)
  高橋俊昭
- Organizer
  Neuro2007 (合同学会 ; 日本神経科学大会、日本神経化学会大会、日本神経回路学会大会)
- Place of Presentation
  横浜市
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-19790602
[Presentation] Aprataxin, the Causative Gene Product for AOA1/EAOH, Repairs Damaged 3'-ends of DNA Single Strand Breaks2007
- Author(s)
  Masayoshi Tada, Akihide Koyama, Shuichi Igarashi, Akio Yokoseki, Tetsuya Takahashi, Atsushi Shiga, Shoji Tsuji
- Organizer
  59th BOSTON AAN ANNUAL MEETING
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-05-01
- Data Source
  KAKENHI-PROJECT-19390236

1. ONODERA Osamu (20303167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. OZAWA Tetsutaro (10377153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TOYOSHIMA Yasuko (20334675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TADA Masayoshi (10467079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATADA Shinnichi (70599167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Toshiaki 高橋 俊昭

Research Projects

Research Products

Co-Researchers

Polyglutamine oligomers in human brain play a crucial role in the pathogenesis of polyglutamine diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on a molecular basis for the cytotoxicity induced by polyglutamine proteins.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impairment of quality control system for nucleic acids and neurodegenerative disorders.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the toxicity initiated by polyglutamine oligomersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリグルタミン鎖の長さ依存性分解代謝遅延および細胞内局在性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Research Advances in Spinocerebellar Degeneration and Spastic Paraplegia 20082008

Author(s)

Total Pages

Publisher

Data Source

[Book] Research Advances in Spinocerebellar Degeneration and Spastic Paraplegia 2008[Polyglutamine disease:Theraputic strategy depends on cytotoxic structure and dysfunction.]2008

Author(s)

Publisher

Data Source

[Book] 神経研究の進歩(特集 脊髄小脳変性症研究の最近の進歩).2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Polyglutamine diseases : where does toxicity come from? what is toxicity? where are we going?2010

Author(s)

Journal Title

Data Source

[Journal Article] Polyglutamine diseases : where does toxicity come from ? what is toxicity ? where are we going2010

Author(s)

Journal Title

Data Source

[Journal Article] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008

Author(s)

Journal Title

Data Source

[Journal Article] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2008

Author(s)

Journal Title

Data Source

[Journal Article] Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends2007

Author(s)

Journal Title

Data Source

[Presentation] ヒト疾患脳におけるポリグルタミン病重合体の検出2011

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] PML発現賦活によるポリグルタミン病の治療検討2010

TAKAHASHI Toshiaki 高橋俊昭

[Book] 神経研究の進歩(特集脊髄小脳変性症研究の最近の進歩).2006