Shinohara Ken-ichi 篠原憲一

… Alternative Names

SHINOHARA Kenichi 篠原憲一

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Researcher Number	70378561
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2019: 千葉大学, 大学院医学研究院, 助教 2016: 千葉大学, 大学院医学研究院, 特任助教 2014 – 2015: 千葉大学, 医学(系)研究科(研究院), 特任助教 2010: 京都大学, 理学研究科, 助教 2007 – 2010: 京都大学, 大学院・理学研究科, 助教 … More 2008: Kyoto University, 理学研究科, 助教 2006: 京都大学, 大学院理学研究科, 助手 2005: 京都大学, 大学院・理学研究科, 研究員 Less
Review Section/Research Field	Principal Investigator Chemical biology / Living organism molecular science Except Principal Investigator Digestive surgery / Chemistry related to living body
Keywords	Principal Investigator ピロール・イミダゾールポリアミド / エピゲノム制御 / ヒストンメチル化 / 発現制御 / 核酸化学 / ピロール-イミダゾールポリアミド / 核酸 / DNAアルキル化 / テロメア / 遺伝子発現制御 … More / エピジェネティクス / DNA配列認識 / エピゲノム / ピロール・イミダゾール・ポリアミド / 白血病 / PIポリアミド / 細胞老化 / Py-Imポリアミド / 遺伝子 / 配列特異的DNAアルキル化 / ジーンサイレンシング / ピロールイミダゾールポリアミド / 遺伝子発現抑制 / 抗癌剤 … More Except Principal Investigator エピゲノム / 癌 / DNA / 5-ハロウラシル / 修飾塩基 / 光反応性 / 構造機能解析 / 蛋白質 / 核酸 Less

Novel approach to selective modification of histone methylation using DNA-binding small moleculesPrincipal Investigator
- Principal Investigator
  
  Shinohara Ken-ichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Chiba University
Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration
- Principal Investigator
  
  Kaneda Atsushi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Chiba University
Selective modification of histone methylation using DNA binding-small moleculesPrincipal Investigator
- Principal Investigator
  
  Shinohara Ken-ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Chiba University
Cell-biological analysis of sequence-specific DNA alkylating molecules.Principal Investigator
- Principal Investigator
  
  KEN-ICHI Shinohara
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
Chemical Biology of DNA Structure and Functions
- Principal Investigator
  
  SUGIYAMA Hiroshi
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Kyoto University
アルキル化ピロール-イミダゾールポリアミドによる細胞内在性遺伝子の特異的発現抑制Principal Investigator
- Principal Investigator
  
  篠原憲一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University

All 2019 2018 2017 2016 2015 2014 2010 2009 2008 2007 2006

All Journal Article Presentation Patent

[Journal Article] Synthsis of LSD1 Inhibitor-Pyrrole-Imidazole Polyamide Conjugates for Region-Specific Alterations of Histone Modification2019
- Author(s)
  Qin R, Takayanagi S, Kondo Y, Li J, Shiga N, Nakajima M, Shinohara K, Yoda N, Suzuki T, Kaneda A, and Nemoto T
- Journal Title
  
  Heterocycles
  
  Volume: － Issue: 2 Pages: 891-905
- DOI
  10.3987/com-18-s(f)57
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-18K19572
[Journal Article] Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide2018
- Author(s)
  Alagarswamy K, Shinohara K, Takayanagi S, Fukuyo M, Okabe A, Rahmutulla B, Yoda N, Qin R, Shiga N, Sugiura M, Sato H, Kita K, Suzuki T, Nemoto T, Kaneda A
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 50 Pages: 29316-29335
- DOI
  10.18632/oncotarget.25451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-18K19572
[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017
- Author(s)
  篠原憲一、金田篤志
- Journal Title
  
  Medical Science Digest
  
  Volume: 43 Pages: 116-121
- Data Source
  KAKENHI-PROJECT-26350977
[Journal Article] Synthesis of Pyrrole-Imidazole Polyamide Oligomers Based on a Copper-Catalyzed Cross-Coupling Strategy.2017
- Author(s)
  Shiga N, Takayanagi S, Muramoto R, Murakami T, Qin R, Suzuki Y, Shinohara K, Kaneda A, Nemoto T.
- Journal Title
  
  Bioorg Med Chem Lett,
  
  Volume: 27 Issue: 10 Pages: 2197-2200
- DOI
  10.1016/j.bmcl.2017.03.052
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-16K15608
[Journal Article] Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.2017
- Author(s)
  Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A.
- Journal Title
  
  Cancer Letters
  
  Volume: 407 Pages: 21-31
- DOI
  10.1016/j.canlet.2017.08.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08729, KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16530
[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017
- Author(s)
  篠原憲一、金田篤志
- Journal Title
  
  Medical Science Digest
  
  Volume: 43 Pages: 72-75
- Data Source
  KAKENHI-PROJECT-17K01959
[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017
- Author(s)
  篠原憲一、金田篤志
- Journal Title
  
  Medical Science Digest
  
  Volume: 43 Pages: 72-75
- Data Source
  KAKENHI-PROJECT-16K15608
[Journal Article] ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression2017
- Author(s)
  Watanabe Yosuke、Ishizuka Yoshiaki、Hirano Takayuki、Nagasaki-Maeoka Eri、Hoshi Reina、Yoshizawa Shinsuke、Uekusa Shota、Kawashima Hiroyuki、Sugito Kiminobu、Shinohara Kenichi、Fukuda Noboru、Nagase Hiroki、Soma Masayoshi、Koshinaga Tsugumichi、Fujiwara Kyoko
- Journal Title
  
  Med Oncol
  
  Volume: 34 Issue: 9 Pages: 158-158
- DOI
  10.1007/s12032-017-0999-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01959, KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-17H03602
[Journal Article] Platinum-Catalyzed Friedel-Crafts-Type C–H Coupling–Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles2016
- Author(s)
  Yuta Suzuki, Yuito Tanaka, Shun-ichi Nakano, Kousuke Dodo, Natsumi Yoda, Ken-ichi Shinohara, Kazuko Kita, Atushi Kaneda, Mikiko Sodeoka, Yasumasa Hamada, and Tetsuhiro Nemoto
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 22 Issue: 13 Pages: 4418-4421
- DOI
  10.1002/chem.201600375
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07850, KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-14J02661, KAKENHI-PLANNED-26110004
[Journal Article] Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide.2016
- Author(s)
  Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A.
- Journal Title
  
  ACS Omega
  
  Volume: 1 Issue: 6 Pages: 1164-1172
- DOI
  10.1021/acsomega.6b00229
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001, KAKENHI-PROJECT-16K15608
[Journal Article] Double beta-alanine substitutions incorporated in 12-ring pyrrole-Imidazole Polyamides for lengthened DNA minor groove recognition.2016
- Author(s)
  Watanabe T, Shinohara K, Shinozaki Y, Uekusa S, Wang X, Koshikawa N, Hiraoka K, Inoue T, Lin J, Bando T, Sugiyama H and Nagase H.
- Journal Title
  
  Advanced Techniques in Biology & Medicine.
  
  Volume: 4 Issue: 02 Pages: 175-175
- DOI
  10.4172/2379-1764.1000175
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01579, KAKENHI-PROJECT-16J05439, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001
[Journal Article] Silencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death.2015
- Author(s)
  Sugimoto H, Nakamura M, Yoda H, Hiraoka K, Shinohara K, Sang M, Fujiwara K, Shimozato O, Nagase H, Ozaki T.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 6 Issue: 10 Pages: e1914-e1914
- DOI
  10.1038/cddis.2015.242
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060
[Journal Article] Inhibition of KRAS Codon 12 Mutants Using a Novel DNA-alkylating Pyrrole-imidazole Polyamide Conjugate2015
- Author(s)
  Hiraoka, K.; Inoue, T.; Taylor, R. D.; Watanabe, T.; Koshikawa, N.; Yoda, H.; Shinohara, K.; Takatori, A.; Sugimoto, K.; Maru, Y.; Denda, T.; Fujiwara, K.; Balmain, A.; Ozaki, T.; Bando, T.; Sugiyama, H.; Nagase, H.
- Journal Title
  
  Nature. Comm.
  
  Volume: in press
- NAID
  120006460100
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26350977
[Journal Article] Modulation of the EMT/MET Process by Pyrrole-Imidazole Polyamide Targeting Human Transforming Growth Factor-β1.2015
- Author(s)
  Saito, K.; Fukuda, N.; Shinohara, K.; Masuhiro, Y.; Hanazawa, S.; Matsuda, H.; Fujiwara, K.; Ueno, T.; Soma, M.
- Journal Title
  
  Int. J. Biochem. Cell Biol.
  
  Volume: 66 Pages: 112-20
- DOI
  10.1016/j.biocel.2015.07.011
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-26830134
[Journal Article] Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate.2014
- Author(s)
  Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H.
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Issue: 1 Pages: 6706-6706
- DOI
  10.1038/ncomms7706
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PUBLICLY-25134718, KAKENHI-PROJECT-25871150, KAKENHI-PUBLICLY-26112517, KAKENHI-PROJECT-26290060, KAKENHI-PROJECT-15K08412, KAKENHI-PROJECT-26350977, KAKENHI-PROJECT-25461573, KAKENHI-PROJECT-24310155, KAKENHI-PROJECT-24225005
[Journal Article] Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates.2010
- Author(s)
  Kashiwazaki, G.; Bando, T.; Shinohara, K.; Mioshima, M.; Kumamoto, H.; Nishijima, S.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.18
  
  Pages: 2887-2893
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Comparative Analysis of DNA Alkylation by Conjugates between Pyrrole-Imidazole Hairpin Polyamides and Chlorambucil or seco-CBI.2010
- Author(s)
  Minoshima, M.; Bando, T.; Shinohara, K.; Kashiwazaki, K.; Nishijima, S.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.18
  
  Pages: 1236-1243
- NAID
  120001887644
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Chiral Wedge Moleculeinhibits Telomerase Activity.2010
- Author(s)
  Shinohara, K., Sannohe,Y., Kaieda, S., Tanaka, K., Osuga, H., Xu, Y., Bando, T., Sugiyama, H.
- Journal Title
  
  J.Am.Chem.Soc. 132
  
  Pages: 3778-3782
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Chiral Wedge Molecule inhibits Telomerase Activity.2010
- Author(s)
  Shinohara, K.; Sannohe, Y.; Kaieda, S.; Tanaka, K.; Osuga, H.; Xu, Y.; Bando, T.; Sugiyama, H.
- Journal Title
  
  J. Am. Chem Soc. vol.132
  
  Pages: 3778-3782
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Alkylation of a human telomere sequence by heterotrimeric chlorambucil PI polyamide conjugates.2010
- Author(s)
  Gengo Kashiwazaki, Toshikazu Bando, Ken-ichi Shinohara, Masafumi Minoshima, Hana Kumamoto, Shigeki Nishijima, Hiroshi Sugiyama
- Journal Title
  
  Bioorganic & Medicinal Chemistry 18
  
  Pages: 2887-2893
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Cell Permeability of Py-Im Polyamide - Fluorescein Conjugates: Influence of Molecular Size and Py/Im Content.2010
- Author(s)
  Nishijima, S; Shinohara, K.; Bando, T.; Minoshima, M.; Kashiwazaki, G.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.18
  
  Pages: 978-983
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Potent Activity against K562 Cells by Polyamide - seco -CBI Conjugates Targeting Histone H4 Genes.2010
- Author(s)
  Minoshima, M.; Chou, J.C.; Lefebvre, S.; Bando, T.; Shinohara, K.; Gottesfeld, J.M.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.18
  
  Pages: 168-174
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Anticancer Activities of Alkylating Pyrrole-Imidazole Polyamides with Specific Sequence Recognition.2010
- Author(s)
  Shinohara, K.; Bando, T.; Sugiyama, H.
- Journal Title
  
  Anti - Cancer Drug vol.21
  
  Pages: 228-242
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Alkylation of a Human Telomere Sequence by Heterotrimeric Chlorambucil PI Polyamide Conjugates.2010
- Author(s)
  Kashiwazaki, G., Bando, T., Shinohara, K., Mioshima, M., Kumamoto, H., Nishijima, S., Sugiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 2887-2893
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Comparative Analysis of DNA Alkylation by Conjugates between Pyrrole-Imidazole Hairpin Polyamides and Chlorambucil or seco-CBI.2010
- Author(s)
  Minoshima, M., Bando, T., Shinohara, K., Kashiwazaki, K., Nishijima, S., Sugiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 18
  
  Pages: 1236-1243
- NAID
  120001887644
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Anticancer Activities of Alkylating Pyrrole-Imidazole Polyamides with Specific Sequence Recognition2010
- Author(s)
  Ken-ichi Shinohara, Toshikazu Bando, Hiroshi Sugiyama
- Journal Title
  
  Anti-Cancer Drug 21
  
  Pages: 228-242
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Chiral wedge molecule inhibits telomerase activity2010
- Author(s)
  Ken-ichi Shinohara, Yuta Sannohe, Shuji Kaieda, Ken-ichi Tanaka, Hideji Osuga, Hidetoshi Tahara, Yan Xu, Takashi Kawase, Toshikazu Bando, Hiroshi
- Journal Title
  
  Journal of the American Chemical Society 132
  
  Pages: 3778-3782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Chiral Wedge Molecule inhibits Telomerase Activity.2010
- Author(s)
  Shinohara, K., Sugiyama, H.
- Journal Title
  
  J.Am.Chem.Soc.
  
  Volume: 132 Pages: 3778-3782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Cooperative Alkylation of Double-strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-pair Recognition Based on a Heterotrimeric Design2009
- Author(s)
  Kashiwazaki, G. Bando, T. ; Shinohara, K. ; Minoshima, M. ; Nishijima, S. ; Sugiyama, H.
- Journal Title
  
  Bioorganic Medicinal Chemistry 17
  
  Pages: 1393-1397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Synthesis and Properties of Polyamide - SAHA Conjugate.2009
- Author(s)
  Ohtsuki, A.; Kimura, M.T.; Minoshima, M.; Suzuki, T.; Ikeda, M.; Bando, T.; Nagase, H.; Shinohara, K.; Sugiyama, H.
- Journal Title
  
  Tetrahedron Lett. vol.50
  
  Pages: 7288-7292
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Cooperative Alkylation of Double strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-pair Recognition Based on a Heterotrimeric Design.2009
- Author(s)
  Kashiwazaki, G., Bando, T., Shinohara, K., Minoshima, M., Nishijima, S., Sugiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 1393-1397
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] The Orientation of the Ends of G-Quadruplex Structures Investigated using End-Extended Oligonucleotides2009
- Author(s)
  Sannohe, Y., Sato, K., Matsugami, A., Shinohara, K., Mashimo, T., Katahira, M., Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. 17
  
  Pages: 1870-1875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Cooperative Alkylation of Double-strand Human Telomere Repeat Sequences by PI Polyamides with 11-Base-pair Recognition Based on a Heterotrimeric Design.2009
- Author(s)
  Kashiwazaki, G. Bando, T.; Shinohara, K.; Minoshima, M.; Nishijima, S.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.17
  
  Pages: 1393-1397
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] The Orientation of the Ends of G-Quadruplex Structures Investigated using End-Extended Oligonucleotides.2009
- Author(s)
  Sannohe, Y., Sato, K., Matsugami, A., Shinohara, K., Mashimo, T., Katahira, M., Sugiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 19
  
  Pages: 1870-1875
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Sequence-Specific Alkylation by Y-Shaped and Tandem Hairpin Pyrrole-Imidazole Polyamides.2008
- Author(s)
  Sasaki, S., Bando, T., Minoshima, M., Shinohara, K., Sugiyama, H.
- Journal Title
  
  Chem.Eur.J. 18
  
  Pages: 864-870
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Detection of Triplet Repeat Sequences in the Double - Stranded DNA using Pyrene - Functionalized Pyrrole - Imidazole Polyamides with Rigid Linkers.2008
- Author(s)
  Fujimoto, J.; Bando, T.; Minoshima, M.; Uchida, S.; Iwasaki, M.; Shinohara, K.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.16
  
  Pages: 5899-5907
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Perylene - Conjugated Pyrrole Polyamide as a Sequence-Specific Fluorescent Probe.2008
- Author(s)
  Fujimoto, J.; Bando, T.; Minoshima, M.; Kashiwazaki, G.; Nishijima, S.; Shinohara, K.; Sugiyama, H.
- Journal Title
  
  Bioorg. Med. Chem. vol.16
  
  Pages: 9741-9744
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Perylene-Conjugated Pyrrole Polyamide as a Sequence-Specific Fluorescent Probe2008
- Author(s)
  Fujimoto, J. ; Bando, T. ; Minoshima, M. ; Kashiwazaki, G. ; Nishijima, S. ; Shinohara. K. ; Sugiyama, H.
- Journal Title
  
  Bioorganic & Medicinal Chemistry 16
  
  Pages: 9741-9749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Requirement of β-Alanine Components in Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Conjugates with Seven-Base Pair Recognition.2008
- Author(s)
  Bando, T., Minoshima, M., Kashiwazaki, G., Shinohara, K., Sasaki, S., Fujimoto, J., Ohtsuki, A., Murakami, M., Nakazono, S., Sugiyama, H.
- Journal Title
  
  Bioorg.Med.Chem. 16
  
  Pages: 2286-2291
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Stable Lariat Formation Based on a G-quadruplex Scaffold2008
- Author(s)
  Xu, Y. ; Sato, H. ; Sannohe, Y. ; Shinohara, K. : Sueivama. H.
- Journal Title
  
  Journal of the American Chemical Society 130
  
  Pages: 16470-16471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20710164
[Journal Article] Stable Lariat Formation Based on a G-Quadruplex Scaffold.2008
- Author(s)
  Xu, Y., Sato, H., Sannohe, Y., Shinohara, K., Sugiyama, H.
- Journal Title
  
  J.Am.Chem.Soc. 130
  
  Pages: 16470-16471
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker : Sequence-Specific DNA Alkylation with Ten-Base-Pair Recognition through Hetelodimer Formation.2007
- Author(s)
  Minoshima, M., Bando, T., Sasaki, S., Shinohara, K., Shimizu, T., Fujimoto, J., Sugiyama, H.
- Journal Title
  
  Journal of the American Chemical Society (印刷中)
- Data Source
  KAKENHI-PROJECT-17710185
[Journal Article] DNA Alkylation by Pyrrole-Imidazole seco-CBI Conjugates with an Indole Linker : Sequence-Specific DNA Alkylation with Ten-Base-Pair Recognition throug Hetelodimer Formation.2007
- Author(s)
  Minoshima, M., Bando, T., Sasaki, S., Shinohara, K., Shimizu, T., Fujimoto, J., Sugiyama, H.
- Journal Title
  
  J.Am.Chem.Soc. 129
  
  Pages: 5384-5390
- Data Source
  KAKENHI-PROJECT-19205023
[Journal Article] Alkylation of templae strand of coding region causes effective gene silencing2006
- Author(s)
  Shinohara, K., Bando, T., Sugiyama, H.
- Journal Title
  
  Nucleic Acids Research 34・4
  
  Pages: 1189-1195
- Data Source
  KAKENHI-PROJECT-17710185
[Journal Article] Sequence-Specific Alkylation of Double-Strand Human Telomere Repeat Sequence by Pyrrole-Imidazole Polyamides with Indole Linkers.2006
- Author(s)
  Sasaki, S., Bando, T., Minoshima, M., Shimizu, T., Shinohara, K., Takaoka, T.
- Journal Title
  
  Journal of the American Chemical Society 128
  
  Pages: 12162-12168
- Data Source
  KAKENHI-PROJECT-17710185
[Journal Article] Antitumor activity of sequence-specific alkylating agents : Pyrolle-imidazole CBI conjugates with indole linker2006
- Author(s)
  Shinohara, K., Bando, T., Sugiyama, H.
- Journal Title
  
  Cancer Science 97・3
  
  Pages: 219-225
- NAID
  10018177438
- Data Source
  KAKENHI-PROJECT-17710185
[Patent] 配列特異的で設計可能な標的遺伝子の転写抑制阻害剤およびこれを含む組成物並びにその使用2017
- Inventor(s)
  金田篤志、篠原憲一、根本哲宏
- Industrial Property Rights Holder
  金田篤志、篠原憲一、根本哲宏
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-01
- Overseas
- Data Source
  KAKENHI-PROJECT-26350977
[Patent] 配列特異的で設計可能な標的遺伝子の転写抑制阻害剤およびこれを含む組成物並びにその使用2017
- Inventor(s)
  金田篤志、篠原憲一、根本哲宏
- Industrial Property Rights Holder
  金田篤志、篠原憲一、根本哲宏
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-01
- Overseas
- Data Source
  KAKENHI-PROJECT-16K15608
[Patent] 遷移金属触媒反応を利用した 3,4 位中員環縮環 3-アルキリデンインドリン類、および 3,4 位中員環縮インドール類の合成法2016
- Inventor(s)
  根本哲宏、濱田康正、鈴木雄太、仲野駿一、篠原憲一、金田篤志、他
- Industrial Property Rights Holder
  根本哲宏、濱田康正、鈴木雄太、仲野駿一、篠原憲一、金田篤志、他
- Industrial Property Rights Type
  特許
- Filing Date
  2016-08-12
- Data Source
  KAKENHI-PROJECT-26350977
[Presentation] がんエピゲノム異常に焦点を当てた塩基配列選択的 DNA 結合小分子の開発2019
- Author(s)
  篠原憲一, 依田夏美, 覃睿, 福世真樹, 岡部篤史, 中島誠也, 鈴木孝禎, Rahmutulla Bahityar, 根本哲宏, 金田篤志
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] PIP-LSD1選択的阻害剤ハイブリッド分子の合成と機能評価2019
- Author(s)
  Rui Qin，高柳志穂理，滋賀直樹，Kokiladevi Alagarswamy，篠原憲一，鈴木孝禎，金田篤志，根本哲宏
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] LSD1 Inhibitor Conjugated with PI Polyamide Enhances Region Specific Activation of Genomic Regions2018
- Author(s)
  Kokiladevi Alagarswamy, Ken-ichi Shinohara, Shihori Takayanagi, Masaki Fukuyo, Atsushi Okabe, Bahityar Rahmutulla, Natsumi Yoda, Rui Qin, Naoki Shiga, Kazuko Kita, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda
- Organizer
  Vanderbilt-Ingram Cancer Center Annual Scientific Retreat
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] 癌エピゲノム異常の制御を目指した塩基配列選択的DNA結合小分子の開発2018
- Author(s)
  篠原憲一, 依田夏美, 覃睿, 福世真樹, 岡部篤史, Alagarswamy Kokiladevi, 仲野駿一, 鈴木孝禎, 根本哲宏, 金田篤志
- Organizer
  第27回日本癌病態治療研究会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] PIP-LSD1選択的阻害剤ハイブリッド分子の合成と機能評価2018
- Author(s)
  覃睿、高柳志穂里, 滋賀直樹、Alagarswamy KOKILADEVI、篠原憲一、鈴木孝禎、金田篤志、根本哲宏
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] DNA結合小分子を応用した領域選択的エピゲノム制御概念の開発2018
- Author(s)
  篠原憲一, 依田夏美, 福世真樹, 岡部篤史, Kokiladevi Alagarswamy, Bahityar Rahmutulla, 覃睿, 中島誠也, 喜多和子, 鈴木孝禎, 根本哲宏, 金田篤志
- Organizer
  第41回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] DNA結合小分子とLSD1阻害剤の融合化合物による新規エピゲノム標的薬剤の開発2018
- Author(s)
  依田夏美, 篠原憲一, 岡部篤史, 根本哲宏, 福世真樹, 喜多和子, 金田篤志
- Organizer
  平成30年度関東研究医養成コンソーシアム　第9回夏のリトリート
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] Region specific alteration of histone modification using LSD1 inhibitor conjugated with Pyrrole Imidazole Polyamide.2017
- Author(s)
  Kokiladevi Alagarswamy, Ken-ichi Shinohara, Atsushi Okabe, Masaki Fukuyo, Natsumi Yoda, Hiroki Nagase, Takayoshi Suzuki, Tetsuhiro Nemoto, Atsushi Kaneda.
- Organizer
  76th Annual Meeting of the Japanese Cancer Association,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15608
[Presentation] DNA配列を認識する小分子による選択的 DNAメチル化阻害.2017
- Author(s)
  篠原憲一、依田夏美、福世真樹、喜多和子、根本哲宏、金田篤志.
- Organizer
  2017年度生命科学系学会合同年次大会、
- Data Source
  KAKENHI-PROJECT-16K15608
[Presentation] Epigenetic driver of tumorigenesis in gastrointestinal cancer2017
- Author(s)
  Atsushi Kaneda, Keisuke Matsusaka, Eiji Sakai, Kenichi Shinohara, Natsumi Yoda, Hiroki Nagase, Tetsuhiro Nemoto, Kokiladevi Alagarswamy, Takayoshi Suzuki, Masaki Fukuyo, Atsushi Okabe, Kiyoko Takane, Sayaka Funata, Hiroe Namba
- Organizer
  International symposium for the drug-discovery of the pyrrole-imidazole polyamides as novel biomedicines
- Place of Presentation
  日本大学桜門会館（東京都・東京）
- Year and Date
  2017-02-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15608
[Presentation] DNA配列を認識する小分子による選択的 DNAメチル化阻害2017
- Author(s)
  篠原憲一、依田夏美、福世真樹、喜多和子、根本哲宏、金田篤志
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K01959
[Presentation] DNA結合小分子を用いた選択的DNAメチル化阻害2016
- Author(s)
  篠原憲一
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Place of Presentation
  京都テルサテルサホール（京都府・京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26350977
[Presentation] DNA配列認識小分子によるエピゲノム制御2015
- Author(s)
  篠原憲一, 依田夏美, 渡部隆義, 永瀬浩喜, 金田篤志
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市中央区）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26350977
[Presentation] PIポリアミドコンジュゲートによる配列特異的DNAアルキル化反応2009
- Author(s)
  板東俊和, 蓑島維文, 篠原・憲一, 杉山弘
- Organizer
  第12回がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19205023
[Presentation] Chiral wedge molecule inhibits telomerase activity2009
- Author(s)
  篠原憲一、三戸祐太、大須賀秀次、徐岩、杉山弘
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20710164
[Presentation] Chiral wedge molecule inhibits telomerase activity2009
- Author(s)
  篠原憲一
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20710164
[Presentation] テロメアを標的とするピロール-イミダゾールポリアミド2008
- Author(s)
  篠原憲一、板東俊和、杉山弘
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20710164

1. SUGIYAMA Hiroshi (50183843)

# of Collaborated Projects: 3 results

# of Collaborated Products: 29 results
2. BANDO Toshikazu (20345284)

# of Collaborated Projects: 2 results

# of Collaborated Products: 24 results
3. KANEDA Atsushi (10313024)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. NEMOTO Tetsuhiro (80361450)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. SUZUKI Takayoshi (90372838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. NAGASE Hiroki (90322073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. WATANABE Takayoshi (60526060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. YODA Natsumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. FUKUYO Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. TAKANE Kiyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. FUJIWARA Kyoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. KITA Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUKUDA Noboru

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 尾崎俊文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 篠原隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinohara Ken-ichi 篠原 憲一

SHINOHARA Kenichi 篠原 憲一

Research Projects

Research Products

Co-Researchers

Novel approach to selective modification of histone methylation using DNA-binding small moleculesPrincipal Investigator

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Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration

Principal Investigator

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Selective modification of histone methylation using DNA binding-small moleculesPrincipal Investigator

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Cell-biological analysis of sequence-specific DNA alkylating molecules.Principal Investigator

Principal Investigator

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Chemical Biology of DNA Structure and Functions

Principal Investigator

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アルキル化ピロール-イミダゾールポリアミドによる細胞内在性遺伝子の特異的発現抑制Principal Investigator

Principal Investigator

Project Period (FY)

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[Journal Article] Synthsis of LSD1 Inhibitor-Pyrrole-Imidazole Polyamide Conjugates for Region-Specific Alterations of Histone Modification2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of Pyrrole-Imidazole Polyamide Oligomers Based on a Copper-Catalyzed Cross-Coupling Strategy.2017

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[Journal Article] Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.2017

Author(s)

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[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017

Author(s)

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[Journal Article] ゲノム領域選択的なエピゲノム制御アプローチ2017

Author(s)

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[Journal Article] ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression2017

Author(s)

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Data Source

[Journal Article] Platinum-Catalyzed Friedel-Crafts-Type C&#8211;H Coupling&#8211;Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles2016

Author(s)

Shinohara Ken-ichi 篠原憲一

SHINOHARA Kenichi 篠原憲一

[Journal Article] Platinum-Catalyzed Friedel-Crafts-Type C–H Coupling–Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles2016