Shimizu Masato 清水真人

… Alternative Names

清水真人シミズマサト

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Researcher Number	70380277
Affiliation (Current)	2025: 大阪大学, 大学院歯学研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2016 – 2023: 大阪大学, 歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Conservative dentistry Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Basic Section 57040:Regenerative dentistry and dental engineering-related
Keywords	Principal Investigator コラーゲン / 象牙質 / 質量顕微鏡 / 歯髄内結石 / 質量イメージング / 質量分析 / 石灰化 / ２型糖尿病 / 糖化最終産物 / 高分解能質量分析 … More / 歯髄内石灰化 / 異所性石灰化 / アラゲブリウム / 質量イメージング解析 / HPLC解析 / RAGE/AGEｓシグナル / 架橋型AGEｓ / 糖化最終産物AGEｓ / AGEs受容体（ＲＡＧＥ） / 蛍光分光分析 / HPLC分析 / Western blot / 架橋型糖化最終産物 / 糖化最終産物（AGEｓ） / AGEs阻害剤（アラゲブリウム） / RAGE阻害剤（FPS-ZＭ1） / 蛍光検出 / 架橋型AGEs / AGEs受容体（RAGE） / コラーゲンの糖化 / 免疫染色 / 蛍光分析 / RAGE阻害薬FPS-ZM1 / AGEs阻害薬アラゲブリウム / 架橋型AGEsペントシジン / 糖化最終産物（AGEs） / 免疫組織染色 / RAGE / MALDI-TOF　mass / ISD / インソース分解質量分析法 / MALDインソース分解質量分析 / ラット尾腱コラーゲン / ２型糖尿病モデルラット / 象牙質コラーゲン / MALDI インソース分解質量分析 / AGEs / イメージング質量分析 / 質量顕微鏡法 / 分析科学 / 糖尿病 / 老化 / 加齢 / 蛍光 / ペントシジン … More Except Principal Investigator 象牙質 / 糖化最終産物 / 血管障害 / 老化 / 異栄養性石灰化 / 歯周病 / 糖化コラーゲン / 細胞障害 / 石灰化 / 糖尿病 / 歯髄細胞 / 歯髄 / コラーゲン / 加齢 / 糖化 / オミクス / 代謝 / 組織再生 / メタオミクス / オミクス解析 / 歯周組織再生 / FGF-2 Less

Research of glycation stress in pulp, periodontal diseases and novel therapeutic mechanisms
- Principal Investigator
  
  三浦治郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Elucidation of the mechanism of ectopic calcification by high-resolution mass spectrometryPrincipal Investigator
- Principal Investigator
  
  Shimizu Masato
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Mechanism of Ectopic Calcification of Dental Pulp Caused by Glycation and Development of Clinical Application Methods
- Principal Investigator
  
  Miura Jiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Analysis of metabolic adaptation and three-dimensional structure changes caused by regenerative therapy with FGF-2.
- Principal Investigator
  
  NOZAKI TAKENORI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Osaka University
The pathogenic calcification mechanism in the dental pulp through AGEs/RAGE signal pathway elucidated by the imaging mass spectroscopyPrincipal Investigator
- Principal Investigator
  
  Shimizu Masato
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Osaka University
Distribution of pentosidine in dentin collagenPrincipal Investigator
- Principal Investigator
  
  Shimizu Masato
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Conservative dentistry
- Research Institution
  Osaka University

All 2023 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Glycation promotes pulp calcification in Type 2 diabetes rat model2023
- Author(s)
  Takashima Aoi、Miura Jiro、Sugiyama Keita、Shimizu Masato、Okada Misa、Otani Tomohiro、Nagashima Tadashi、Tsuda Tetsuya、Araki Tsutomu
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 2 Pages: 593-603
- DOI
  10.1111/odi.14529
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09973, KAKENHI-PROJECT-21K21063, KAKENHI-PROJECT-22K17056, KAKENHI-PROJECT-21K09873
[Journal Article] Effects of advanced glycation end products on dental pulp calcification2021
- Author(s)
  Sugiyama Keita、Miura Jiro、Shimizu Masato、Takashima Aoi、Matsuda Yusuke、Kayashima Hiroki、Okamoto Motoki、Nagashima Tadashi、Araki Tsutomu
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 3 Pages: 1-11
- DOI
  10.1111/odi.13792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09973, KAKENHI-PROJECT-18K09596, KAKENHI-PROJECT-18K17047, KAKENHI-PROJECT-20H00552
[Journal Article] Evaluation of avulsed primary incisor in 3-year-old girl with hypophosphatasia who received enzyme replacement therapy2018
- Author(s)
  Okawa R, Miura J Kokomoto K,　Nakano K
- Journal Title
  
  Pediatric Dental Journal
  
  Volume: 28(3) Issue: 1 Pages: 136-140
- DOI
  10.1038/s41598-018-38137-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05517, KAKENHI-PROJECT-19K21379, KAKENHI-PROJECT-18K09596, KAKENHI-PROJECT-19K10136, KAKENHI-PROJECT-17K11712
[Journal Article] Influence of Nonenzymatic Glycation in Dentinal Collagen on Dental Caries2016
- Author(s)
  Y. Matsuda, J. Miura, M. Shimizu, T. Aoki, M. Kubo, S. Fukushima, M. Hashimoto, F. Takeshige, T. Araki T. Araki
- Journal Title
  
  J Dent Res
  
  Volume: 95 Issue: 13 Pages: 1528-1534
- DOI
  10.1177/0022034516662246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K01287, KAKENHI-PROJECT-16H05517, KAKENHI-PROJECT-16H06959
[Presentation] AGEsによる歯髄の器質変化と石灰化現象の解明2023
- Author(s)
  杉山敬多、清水真人、岡田美佐、高島葵、三浦治郎、野﨑剛徳
- Organizer
  第６５回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] AGEsによる歯髄の器質変化と石灰化現象の解明2023
- Author(s)
  杉山敬多，清水真人，高島葵，岡田美佐，野崎剛徳、三浦治郎
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09165
[Presentation] "糖化最終産物（ AGEｓ）修飾されたコラーゲンに対する AGEs阻害薬アラゲブリウムの作用機序の解析"2023
- Author(s)
  清水真人，杉山敬多，高島葵，岡田美佐，野崎剛徳、三浦治郎
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09165
[Presentation] "2型糖尿病モデルラットにおける歯髄内石灰化と AGEs阻害薬の相関について"2023
- Author(s)
  岡田美佐，清水真人，杉山敬多，高島葵，野崎剛徳、三浦治郎
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09165
[Presentation] 糖化最終産物（AGEｓ）修飾されたコラーゲンに対するAGEs阻害薬アラゲブリウムの作用機序の解析2023
- Author(s)
  清水真人、岡田美佐、杉山敬多、高島葵、野﨑剛徳、三浦治郎
- Organizer
  第６５回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] 2型糖尿病モデルラットにおける歯髄内石灰化とAGEs阻害薬の相関について2023
- Author(s)
  岡田美佐、三浦治郎、清水真人、杉山敬多、高島葵、野崎剛徳
- Organizer
  第６５回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] 架橋型糖化最終産物（AGEs）とAGEs阻害薬アラゲブリウムの相互作用の解析2022
- Author(s)
  清水真人、杉山敬多、高島葵、岡田美佐、三浦治郎
- Organizer
  第６４回歯科基礎医学会学術大会（徳島）
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] 糖化ゼラチンスポンジによるラット臼歯部への直接覆髄法の評価2022
- Author(s)
  杉山敬多、清水真人、高島葵、岡田美佐、三浦治郎
- Organizer
  第６４回歯科基礎医学会学術大会（徳島）
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] 糖尿病ラットにおける歯髄内血管糖化と阻害法の検討2022
- Author(s)
  岡田美佐，清水真人，杉山敬多，高島葵，三浦治郎
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09973
[Presentation] 架橋型糖化最終産物（AGEs）と AGEs 阻害薬アラゲブリウムの相互作用の解析2022
- Author(s)
  清水真人，杉山敬多，高島葵，岡田美佐，三浦治郎
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09973
[Presentation] 糖化ゼラチンスポンジによるラット臼歯部への直接覆髄法の評価2022
- Author(s)
  杉山敬多，清水真人，高島葵，岡田美佐，三浦治郎
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09973
[Presentation] 糖尿病ラットにおける歯髄内血管糖化と阻害法の検討2022
- Author(s)
  岡田美佐、清水真人、杉山敬多、高島葵、三浦治郎
- Organizer
  第６４回歯科基礎医学会学術大会（徳島）
- Data Source
  KAKENHI-PROJECT-21K09873
[Presentation] ラット歯髄細胞の石灰化物形成における糖化最終産物（AGEs）の影響2019
- Author(s)
  杉山敬多，三浦治郎，高島葵，清水真人，萱島浩輝
- Organizer
  第６１回歯科基礎医学会（東京）
- Data Source
  KAKENHI-PROJECT-18K09596
[Presentation] 糖化ストレスによって象牙質内に蓄積する糖化最終産物（AGEs）の分布検出方法の検討2019
- Author(s)
  清水真人，三浦治郎，杉山敬多，高島葵
- Organizer
  第６１回歯科基礎医学会（東京）
- Data Source
  KAKENHI-PROJECT-18K09596
[Presentation] 糖化ストレスによって象牙質内に蓄積する糖化最終産物（AGEｓ）の分布2018
- Author(s)
  清水真人　三浦治郎　杉山敬多　高島葵
- Organizer
  第６０回歯科基礎医学会（九州大学）
- Data Source
  KAKENHI-PROJECT-18K09596
[Presentation] Influence of dentinal collagen cross-linking on human dentin with non-enzymatic glycation2017
- Author(s)
  Miura J, Kubo M, Shimizu M, Matsuda Y, Takeshige F, Araki T,
- Organizer
  XXVI Congress of the International Society of Biomechanics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06959
[Presentation] 3-dimensional Analysis of Non-enzymatic Glycation in Caries Using Immunohistochemical FIB/SEM2017
- Author(s)
  Miura J, Matsuda Y, Shimizu M, Kubo M, Takeshige F, Enomoto S, Arai S
- Organizer
  95th General Session of the IADR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06959
[Presentation] 象牙質コラーゲン中の糖化最終産物ペントシジンの分布2017
- Author(s)
  清水真人、三浦治郎
- Organizer
  歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16H06959
[Presentation] ナノインデンテーションにおける象牙質コラーゲン線維の物性評価2016
- Author(s)
  久保　美寿穂、三浦治郎、清水真人、松田祐輔、竹重文雄
- Organizer
  第145回日本歯科保存学会　秋期学術大会
- Data Source
  KAKENHI-PROJECT-16H06959
[Presentation] 象牙質コラーゲン中の架橋型AGEsの検出2016
- Author(s)
  清水真人，三浦治郎
- Organizer
  第５８回　歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-16H06959
[Presentation] 齲蝕罹患象牙質における糖化最終産物AGEs蓄積に関する研究2016
- Author(s)
  松田祐輔、三浦治郎、清水真人、久保美寿穂、竹重文雄
- Organizer
  日本歯科保存学会2016年度春季学術大会(第144回）
- Data Source
  KAKENHI-PROJECT-16H06959

1. MIURA Jiro (70437383)

# of Collaborated Projects: 6 results

# of Collaborated Products: 24 results
2. NOZAKI TAKENORI (30263304)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 大木進野 (70250420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石濱泰 (30439244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 豊田岐聡 (80283828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 北條裕信 (00209214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上垣浩一 (00356544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 長野一也 (40548301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 橋本守

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 福島修一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Masato 清水 真人

清水 真人 シミズ マサト

Research Projects

Research Products

Co-Researchers

Research of glycation stress in pulp, periodontal diseases and novel therapeutic mechanisms

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of ectopic calcification by high-resolution mass spectrometryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of Ectopic Calcification of Dental Pulp Caused by Glycation and Development of Clinical Application Methods

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of metabolic adaptation and three-dimensional structure changes caused by regenerative therapy with FGF-2.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The pathogenic calcification mechanism in the dental pulp through AGEs/RAGE signal pathway elucidated by the imaging mass spectroscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Distribution of pentosidine in dentin collagenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycation promotes pulp calcification in Type 2 diabetes rat model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of advanced glycation end products on dental pulp calcification2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of avulsed primary incisor in 3-year-old girl with hypophosphatasia who received enzyme replacement therapy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of Nonenzymatic Glycation in Dentinal Collagen on Dental Caries2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] AGEsによる歯髄の器質変化と石灰化現象の解明2023

Author(s)

Organizer

Data Source

[Presentation] AGEsによる歯髄の器質変化と石灰化現象の解明2023

Author(s)

Organizer

Data Source

[Presentation] "糖化最終産物（ AGEｓ）修飾されたコラーゲン に対する AGEs阻害薬アラゲブリウムの作用機序 の解析"2023

Author(s)

Organizer

Data Source

[Presentation] "2型糖尿病モデルラットにおける歯髄内石灰化と AGEs阻害薬の相関について"2023

Author(s)

Organizer

Data Source

[Presentation] 糖化最終産物（AGEｓ）修飾されたコラーゲンに対するAGEs阻害薬アラゲブリウムの作用機序の解析2023

Author(s)

Organizer

Shimizu Masato 清水真人

清水真人シミズマサト

[Presentation] "糖化最終産物（ AGEｓ）修飾されたコラーゲンに対する AGEs阻害薬アラゲブリウムの作用機序の解析"2023