KOBAYASHI Takeshi 小林剛

Researcher Number	70380285
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2019: 愛媛大学, 医学系研究科, 寄附講座講師 2016: 愛媛大学, 医学系研究科, 助教 2012 – 2015: 愛媛大学, 医学(系)研究科(研究院), 寄附講座助教 2013: 愛媛大学, 医学(系)研究科(研究院), その他 2013: 愛媛大学, 大学院医学系研究科, 寄附講座助教 … More 2008 – 2012: Ehime University, 大学院・医学系研究科, 寄附講座助教 2011: 愛媛大学, 医学(系)研究科(研究院), 寄付講座助教 2010: 愛媛大学, 大学院・医学系研究科・寄付講座, 助教 Less
Review Section/Research Field	Principal Investigator Ophthalmology Except Principal Investigator Ophthalmology
Keywords	Principal Investigator 形質転換 / 角膜上皮 / 表皮細胞 / 培養上皮シート / 間葉系細胞由来因子 / 角膜輪部 / 角膜実質 / ケラチン12 / 角膜上皮細胞 / 表皮前駆細胞 … More / 角膜上皮再生医療 / シグナルトランスダクション / 組織特異的 / BDNF / 綱膜 / ノックアウトマウス / cfos / 脳由来神経栄養因子 / 網膜 / 正常眼圧 / 緑内障 … More Except Principal Investigator 形質転換 / 再生医療 / 角膜上皮 / 再生医学 / 上皮細胞培養 / 角膜 / 角膜輪部 / 表皮細胞 / 角膜上皮細胞 / 幹細胞マーカー / 眼科学 / ドキシサイクリン / 上皮 / 眼瞼 / 遺伝子組み換えマウス / 線維芽細胞増殖因子７ / 遺伝子組換えマウス / ドライアイ / 性ホルモン / 線維芽細胞増殖因子7 / マイボーム腺 / 培養 / マウス角膜 / ケラチン12 / マウス角膜上皮細胞 / マウス表皮細胞 / 眼発生 Less

Epithelial-mesenchymal interaction in the tras-differentiation from mouse epidermal cells to corneal epithelial cells
- Principal Investigator
  
  Shiraishi Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
An examination of factors for transdifferentiation of mouse epidermal sp cells into corneal epithelial cells
- Principal Investigator
  
  Shiraishi Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
An examination of corneal epithelium reconstruction by transdifferentiation from mouse epidermal cells to corneal epithelial-like cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
Identification of stem cell marker of mouse corneal epithelial cell
- Principal Investigator
  
  SHIRAISHI Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
Sex Hormone Effect on FGF7 Signaling andApplication for Dry Eye
- Principal Investigator
  
  HAYASHI Yasuhito
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
Examination of factors involved in transdifferentiation from mouse epidermal cells to corneal epithelial-like cellsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takeshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
Transdifferentiation induction of murine epidermal SP cells into corneal epithelial cells.
- Principal Investigator
  
  SHIRAISHI Atsushi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University
Normal tension glaucoma model: Characterization of retinal neuron specific BDNF and cfos knockoutPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Takeshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Ehime University

All 2019 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation Patent

[Journal Article] Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival nepithelial cell line.2019
- Author(s)
  Mitani A, Kobayashi T, Hayashi Y, Matsushita N, Matsushita S, Nakao S, Takahira N, Shiraishi A, Ohashi Y.
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 9 Pages: e0222454-e0222454
- DOI
  10.1371/journal.pone.0222454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11484
[Journal Article] Mechanism of Proliferation of Cultured Human Corneal Endothelial Cells.2017
- Author(s)
  Joko T, Shiraishi A, Kobayashi T, Ohashi Y, Higashiyama S.
- Journal Title
  
  Cornea.
  
  Volume: Suppl Issue: 1 Pages: S41-S45
- DOI
  10.1097/ico.0000000000001337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11484
[Journal Article] Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction2016
- Author(s)
  Inoue T, Hara Y, Kobayashi T, Zheng X, Suzuki T, Shiraishi A, Ohashi Y
- Journal Title
  
  Jpn J Ophthalmol.
  
  Volume: 60 Issue: 5 Pages: 349-56
- DOI
  10.1007/s10384-016-0459-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462691
[Journal Article] Miraflow, Soft Contact Lens Cleaner, activity against Acanthamoeba spp.2015
- Author(s)
  Kobayashi T, Higuchi-Watanabe N, Shiraishi A ,Uno T, Ohashi Y
- Journal Title
  
  Eye & Contact Lens.
  
  Volume: in press Issue: 4 Pages: 240-244
- DOI
  10.1097/icl.0000000000000112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592672
[Journal Article] Miraflow, Soft Contact Lens Cleaner: Activity Against Acanthamoeba Spp.2015
- Author(s)
  Kobayashi T, Higuchi-Watanabe N, Shiraishi A, Uno T, Ohashi Y.
- Journal Title
  
  Eye Contact Lens
  
  Volume: Jan 19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462691
[Journal Article] Stromaleepithelial interaction study: The effect of corneal epithelial cells on growth factor expression in stromal cells using organotypic culture model2015
- Author(s)
  Kobayashi T, Shiraishi A, Hara Y, Kadota Y, Yang L, Inoue T, Shirakata Y, Ohashi Y
- Journal Title
  
  Experimental Eye Research
  
  Volume: in press Pages: 109-17
- DOI
  10.1016/j.exer.2015.02.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592672, KAKENHI-PROJECT-26462691
[Journal Article] Horizontal intracorneal swirling water migration indicative of corneal endothelial function2014
- Author(s)
  Inoue T, Kobayashi T, Nakao S , Hara Y, Suzuki T, Hayashi Y, Zheng X, Shiraishi A, Ohashi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 55 Issue: 12 Pages: 8006-14
- DOI
  10.1167/iovs.14-14762
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592672, KAKENHI-PROJECT-26462691
[Journal Article] Necrotizing Keratitis Caused by Acyclovir-Resistant Herpes Simplex Virus2014
- Author(s)
  Toriyama K. Inoue T. Suzuki T. Kobayashi T. Ohashi Y
- Journal Title
  
  Case Rep Ophthalmol
  
  Volume: 5 Issue: 3 Pages: 325-328
- DOI
  10.1159/000368297
- Data Source
  KAKENHI-PROJECT-24592672
[Journal Article] Differences between niche cells and limbal stromal cells in2014
- Author(s)
  Li Y, Inoue T, Takamatsu F, Kobayashi T, Shiraishi A, Maeda N, Ohashi Y,
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 55 Issue: 3 Pages: 1453-62
- DOI
  10.1159/000357105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Genotypic analysis of Pseudomonas aeruginosa isolated from ocular infection2014
- Author(s)
  Yamaguchi S, Suzuki T, Kobayashi T, Oka N, Ishikawa E, Shinomiya H, Ohashi Y
- Journal Title
  
  J Infect Chemother
  
  Volume: 20 Issue: 7 Pages: 407-11
- DOI
  10.1016/j.jiac.2014.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592672, KAKENHI-PROJECT-25861635
[Journal Article] Differences between niche cells and limbal stromal cells in　maintenance of corneal limbal stem cells2014
- Author(s)
  Li Y, Inoue T, Takamatsu F, Kobayashi T, Shiraishi A, Maeda N, Ohashi Y,　Nishida K.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 55 Issue: 3 Pages: 1453-62
- DOI
  10.1167/iovs.13-13698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592672, KAKENHI-PROJECT-24890157, KAKENHI-PROJECT-25253093, KAKENHI-PROJECT-26462691
[Journal Article] Various pAQU plasmids possibly contribute to disseminate tetracycline resistance gene tet(M) among marine bacterial community.2014
- Author(s)
  Nonaka, L., Maruyama, F., Onishi, Y., Kobayashi, T., Ogura, Y., Hayashi, T., Suzuki, S. and Masuda, M.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 5 Pages: 1-12
- DOI
  10.3389/fmicb.2014.00152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22241014, KAKENHI-PROJECT-23780202, KAKENHI-PROJECT-24592672, KAKENHI-PROJECT-25257402
[Journal Article] Involvement of P38MAPK in human corneal endothelial cell migration induced by TGF-β2.2013
- Author(s)
  oko T, Shiraishi A, Akune Y, Tokumaru S, Kobayashi T, Miyata K, Ohashi Y.
- Journal Title
  
  Exp Eye Res.
  
  Volume: 108 Pages: 23-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Involvement of P38MAPK in human corneal endothelial cell migration induced by2013
- Author(s)
  Joko T, Shiraishi A, Akune Y, Tokumaru S, Kobayashi T, Miyata K, Ohashi Y.
- Journal Title
  
  Exp Eye Res.
  
  Volume: 108 Pages: 23-32
- DOI
  10.1016/j.exer.2012.11.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607, KAKENHI-PROJECT-24592672
[Journal Article] Involvement of P38MAPK in human corneal endothelial cell migration induced by TGF-β(2)2013
- Author(s)
  Joko T, Shiraishi A, Akune Y, Tokumaru S, Kobayashi T, Miyata K, Ohashi Y
- Journal Title
  
  Exp Eye Res
  
  Volume: 108 Pages: 23-32
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] 各種フルオロキノロン系抗菌点眼液がヒト培養角膜上皮細胞に与える影響についての検討2013
- Author(s)
  小林剛, 樋口（渡部）成美, 白石敦, 大橋裕一
- Journal Title
  
  医学と薬学
  
  Volume: 70 Pages: 61-66
- Data Source
  KAKENHI-PROJECT-24592672
[Journal Article] Involvement of stem cell factor and c-kit in corneal wound healing in mice2012
- Author(s)
  Miyamoto K, Kobayashi T, Hayashi Y, Zhang Y, Hara Y, Higashine M, Shiraishi A, Ohashi Y.
- Journal Title
  
  Mol Vis.
  
  Volume: 18 Pages: 1505-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592672
[Journal Article] Involvement of stem cell factor and c-kit in corneal wound healing inmice2012
- Author(s)
  Miyamoto, K., Kobayashi, T., Hayashi, Y., Zhang, Y., Hara, Y., Higashine, M., Shiraishi, A., Ohashi, Y
- Journal Title
  
  Mol Vis
  
  Volume: 18 Pages: 1505-1515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591943
[Journal Article] Important Role of Epiregulin in Inflammatory Responses During Corneal Epithelial Wound Healing2012
- Author(s)
  Zhang Y, Kobayashi T, Hayashi Y, Yoshioka R, Shiraishi A, Shirasawa S, Higashiyama S, Ohashi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791665
[Journal Article] Important role of epiregulin in inflammatory responses during corneal epithelial wound healing2012
- Author(s)
  Zhang Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: (In press) Issue: 4 Pages: 2414-2423
- DOI
  10.1167/iovs.11-8869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390102, KAKENHI-PROJECT-22791665, KAKENHI-PROJECT-23592607, KAKENHI-PROJECT-24592672
[Journal Article] Involvement of stem cell factor and c-kit in corneal wound healing in mice.2012
- Author(s)
  Miyamoto K, Kobayashi T, Hayashi Y, Zhang Y, Hara Y, Higashine M, Shiraishi A, Ohashi Y.
- Journal Title
  
  Mol Vis.
  
  Volume: 18 Pages: 1505-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Effect of photodynamic therapy with methylene blue on Acanthamoeba in vitro2012
- Author(s)
  Mito T, Suzuki T, Kobayashi T, Zheng X, Hayashi Y, Shiraishi A, Ohashi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53(10) Pages: 6305-13
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Important role of epiregulin in inflammatory responses during corneal epithelial wound healing2012
- Author(s)
  Zhang, Y., Kobayashi, T., Hayashi, Y., Yoshioka, R., Shiraishi,A., Shirasawa, S., Higashiyama, S., Ohashi, Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53 Pages: 2414-2423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591943
[Journal Article] Important role of epiregulin in inflammatory responses during corneal epithelial wound healing2012
- Author(s)
  Zhang Y, Kobayashi T, Hayashi Y, Yoshioka R, Shiraishi A, Shirasawa S, Higashiyama S, Ohashi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 53(4) Pages: 2414-23
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Effect of photodynamic therapy with methylene blue on acanthamoeba in vitro.2012
- Author(s)
  Mito T, Suzuki T, Kobayashi T, Zheng X, Hayashi Y, Shiraishi A, Ohashi Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 53 Pages: 6305-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Use of 5-cyano-2,3-ditolyl-tetrazolium chloride staining as an indicator of biocidal activity in a rapid assay for anti-Acanthamoeba agents2012
- Author(s)
  Kobayashi T, Mito T, Watanabe N, Suzuki T, Shiraishi A, Ohashi Y
- Journal Title
  
  J Clin Microbiol
  
  Volume: 50(5) Pages: 1606-12
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Important Role of Epiregulin in Inflammatory Responses2012
- Author(s)
  Zhang Y, Kobayashi T, Hayashi Y, Yoshioka R, Shiraishi A, Shirasawa S,
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: Mar 16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Use of 5-cyano-2, 3-ditolyl-tetrazolium chloride(CTC) staining as Indicator of Biocidal Activity in Rapid Assay for Anti-Acanthamoeba Agents2012
- Author(s)
  Kobayashi T, Mito T, Watanabe N, Suzuki T, Shiraishi A, Ohashi Y
- Journal Title
  
  J Clin Microbiol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791665
[Journal Article] Involvement of stem cell factor and c-kit in corneal wound healing in mice2012
- Author(s)
  Miyamoto K, Kobayashi T, Hayashi Y, Zhang Y, Hara Y, Higashine M, Shiraishi A, Ohashi Y
- Journal Title
  
  Mol Vis
  
  Volume: 18 Pages: 1505-15
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Mathematical projection model of visual loss due to fuchs corneal dystrophy2011
- Author(s)
  Hatou S, Shimmura S, Shimazaki J, Usui T, Amano S, Yokogawa H, Kobayashi A, Zheng X, Shiraishi A, Ohashi Y, Inatomi T, Tsubota K
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 52(11) Pages: 7888-93
- Data Source
  KAKENHI-PROJECT-23592607
[Journal Article] Efficacy of commercial soft contact lens disinfectant solutions against Acanthamoeba2011
- Author(s)
  Kobayashi T, Gibbon L, Mito T, Shiraishi A, Uno T, Ohashi, Y
- Journal Title
  
  Jpn J Ophthalmol
  
  Volume: 55 Pages: 547-557
- NAID
  10029689161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791665
[Journal Article] Use of 5-cyano-2, 3-ditolyl-tetrazolium chloride (CTC) staining as Indicator of Biocidal Activity in Rapid Assay for Anti-Acanthamoeba Agents2011
- Author(s)
  Kobayashi T, Mito T, Watanab N, Suzuki T, Shiraishi A, Ohashi Y
- Journal Title
  
  J Clin Microbiol
  
  Volume: 50 Issue: 5 Pages: 1606-612
- DOI
  10.1128/jcm.06461-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791665, KAKENHI-PROJECT-23592607
[Journal Article] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.2010
- Author(s)
  Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 51 Pages: 5630-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] Corneal Epithelial Wound Healing Impaired in Keratinocyte-Specific HB-EGF Deficient Mice In Vivo and In Vitro2010
- Author(s)
  4) Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 51 Pages: 5630-5639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791665
[Journal Article] Corneal Epithelial Wound Healing Impaired in Keratinocyte-Specific HB-EGF Deficient Mice In Vivo and In Vitro2010
- Author(s)
  Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, and Ohashi Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591943
[Journal Article] Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-deficient mice in vivo and in vitro.2010
- Author(s)
  Yoshioka R, Shiraishi A, Kobayashi T, Morita S, Hayashi Y, Higashiyama S, Ohashi Y.
- Journal Title
  
  Invest Ophthalmol Vis Sci. 51(11)
  
  Pages: 5630-5639
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections2009
- Author(s)
  Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y
- Journal Title
  
  Molecular Vision May 8;15
  
  Pages: 937-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] New technique for culturing corneal epithelial cells of normal mice2009
- Author(s)
  Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y
- Journal Title
  
  Molecular Vision Aug 14;15
  
  Pages: 1589-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] Rapid detection of Acanthamoeba cysts in frozen sections of corneal scrapings with Fungiflora Y2009
- Author(s)
  Shiraishi A, Kobayashi T, Hara Y, Yamaguchi M, Uno T, Ohashi Y
- Journal Title
  
  Br J Ophthalmol 93
  
  Pages: 1563-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Journal Article] New technique for culturing corneal epithelial cells of normal mice2009
- Author(s)
  Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y
- Journal Title
  
  Molecular Vision. 15
  
  Pages: 1589-1593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Journal Article] New technique for culturing corneal epithelial cells of normal mice.2009
- Author(s)
  Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y.
- Journal Title
  
  Mol Vis. 15
  
  Pages: 1589-1593
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections2009
- Author(s)
  Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y
- Journal Title
  
  Moleculaz Vision. 15
  
  Pages: 937-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Journal Article] Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial ells to viral infections.2009
- Author(s)
  Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y.
- Journal Title
  
  Mol Vis. 15
  
  Pages: 937-948
- Data Source
  KAKENHI-PROJECT-20592079
[Journal Article] Rapid detection of Acanthamoeba cysts in frozen sections of corneal scra pings with Fungiflora Y2009
- Author(s)
  Shiraishi A, Kobayashi T, Hara Y, Yamaguchi M, Uno T, Ohashi Y
- Journal Title
  
  Br J Ophthalmol. 93
  
  Pages: 1563-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Journal Article] Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections2009
- Author(s)
  Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y.
- Journal Title
  
  Molecular Vision. 15
  
  Pages: 7-948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Journal Article] High Occurrence Rate of Tetracycline (TC)-Resistant Bacteria and TC Resistance Genes Relates to Microbial Diversity in Sediment of Mekong River Main Waterway2008
- Author(s)
  Suzuki S, Kobayashi T, Suehiro F, Tuyen BC, Tana TS
- Journal Title
  
  Microbes and Environments. 23(2)
  
  Pages: 149-152
- NAID
  110006684366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20791257
[Patent] 眼科用組成物2013
- Inventor(s)
  大橋裕一, 白石敦, 小林剛
- Industrial Property Rights Holder
  国立大学法人愛媛大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-077862
- Filing Date
  2013-04-03
- Data Source
  KAKENHI-PROJECT-24592672
[Presentation] ドライアイモデルマウスの結膜囊内涙液貯留量に及ぼすビサコジル点眼の影響2014
- Author(s)
  小林剛
- Organizer
  第38回日本角膜学会総会
- Place of Presentation
  沖縄県宜野湾市
- Data Source
  KAKENHI-PROJECT-24592672
[Presentation] 角膜中央の上皮基底細胞層には胎生期由来の上皮幹細胞が残存する可能性がある2013
- Author(s)
  林　康人, 小林　剛, 白石　敦, 大橋裕一
- Organizer
  角膜カンファランス2013
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-23592607
[Presentation] 皮膚上皮細胞から角膜上皮様細胞への形質転換における実質の関与2013
- Author(s)
  小林剛
- Organizer
  第37回日本角膜学会総会
- Place of Presentation
  和歌山県白浜町
- Data Source
  KAKENHI-PROJECT-24592672
[Presentation] マウス表皮細胞から形質転換した角膜上皮様細胞の免疫組織学的検討2012
- Author(s)
  小林剛, 林康人, 渡部成美, 白石敦, 大橋裕一
- Organizer
  角膜カンファランス2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592607
[Presentation] プロスタグランジン系点眼液の培養眼表面細胞毒性の比較試験2012
- Author(s)
  渡部成美, 小林剛, 白石敦, 大橋裕一
- Organizer
  角膜カンファランス2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592607
[Presentation] 角膜中央の上皮基底細胞層には胎生期由来の上皮幹細胞が残存する可能性がある2012
- Author(s)
  林康人, 小林剛, 白石敦, 大橋裕一
- Organizer
  角膜カンファランス2013
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-22591943
[Presentation] 角膜上皮創傷治癒過程におけるepiregulinの役割2012
- Author(s)
  張媛, 林康人, 小林剛, 吉岡龍治, 白石敦, 大橋裕一
- Organizer
  角膜カンファランス2012
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592607
[Presentation] ソフトコンタクトレンズ用洗浄液(ミラフロー)の抗アカントアメーバ消毒効果の検討2012
- Author(s)
  小林剛, 渡部成美, 白石敦, 宇野敏彦, 大橋裕一
- Organizer
  第49回日本眼感染症学会
- Place of Presentation
  フォーサム2012横浜
- Data Source
  KAKENHI-PROJECT-22591943
[Presentation] マウス表皮細胞から形質転換した角膜上皮細胞の免疫組織学的検討2012
- Author(s)
  小林剛、林康人、渡辺成美、白石敦、大橋裕一
- Organizer
  第36回日本角膜学会総会(角膜カンファランス2012)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] 非典型的な角膜上皮病変を呈した水痘帯状疱疹ウイルス性角膜炎の3例2012
- Author(s)
  友岡真美, 井上智之, 鈴木崇, 小林剛, 原祐子, 鄭暁東, 林康人, 山口昌彦, 白石敦, 大橋裕一
- Organizer
  角膜カンファランス2013
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-22591943
[Presentation] 培養マウス表皮細胞から角膜上皮様細胞への形質転換の検討2010
- Author(s)
  小林剛
- Organizer
  第114回日本眼科学会総会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] 培養マウス表皮細胞から角膜上皮様細胞への形質転換の検討2010
- Author(s)
  小林剛、林康人、白石敦、大橋裕一
- Organizer
  第114回日本眼科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] Role of epiregulin in corneal epithelial wound healing2010
- Author(s)
  Zhang Y, Shiraishi A, Kobayashi T, Yoshioka R, Hayashi Y, Ohashi
- Organizer
  The 25th Asia-Pacific Association of Ophthalmology Meeting
- Place of Presentation
  Beijing, China
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] Epithelial sheets produced from cryooreserved human corneal epithelial cells using dermal fibroblast-embedded collagen gel.2010
- Author(s)
  白石敦, 小林剛, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一
- Organizer
  The 25^<th> APAO Congress - A Joint Meeting of APAO/AAO
- Place of Presentation
  北京、中国
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] Epithelial sheets produced from cryopreserved human corneal epithelial cells using human dermal fibroblast-embedded collagen gel2010
- Author(s)
  Kobayashi T, Shiraishi A, Yang L, Shirakata Y, Hashimoto K, Ohashi Y
- Organizer
  XIX Biennial Meeting of the International Society for Eye Research(ISER 2010)
- Place of Presentation
  Montreal, QC, Canada
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] 培養マウス表皮細胞から角膜上皮様細胞への形質転換の検討.2010
- Author(s)
  小林剛、林康人、白石敦、大橋裕一
- Organizer
  第114回日本眼科学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] 角膜上皮創傷治癒機転における epiregulin の役割の検討2010
- Author(s)
  張媛, 白石敦小林剛, 吉岡龍治, 林康人, 大橋裕一
- Organizer
  第34回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  仙台
- Year and Date
  2010-02-12
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] 凍結保存細胞によるヒト培養角膜上皮シートの作製2010
- Author(s)
  小林剛、白石敦、楊旅軍、白方裕司、橋本公二、大橋裕一
- Organizer
  第34回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] Murine Epidermal Cells Can be Transdifferentiated Into Corneal Epithelial-Like Cells in the Corneal Epithelial Environment2010
- Author(s)
  Shiraishi A, Kobayashi T, Hayshi Y, Ohashi Y
- Organizer
  The Association for Research in Vision and Ophthalmology(ARVO) 2010 Annual Meeting
- Place of Presentation
  Fort Lauderdale, Florida, U. S. A.
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] Epithelial sheets produced from cryooreserved human corneal epithelial cells using dermal fibroblast-embedded collagen gel2010
- Author(s)
  Atsushi SHIRAISHI, Takeshi KOBAYASHI, Lujun YANG, Yuji SHIRAKATA, Koji HASHIMOTO, Yuichi OHASHI
- Organizer
  The 25^<th> APAO Congress-A Joint Meeting of APAO/AAO
- Place of Presentation
  北京,中国
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] HB-EGF is Essential for Promotion of Cell Attachment and Proliferation in Corneal Wound Healing2010
- Author(s)
  Yoshioka R, Shiraishi A, Kobayashi T, Noda E, Hayashi Y, Ohashi Y
- Organizer
  The Association for Research in Vision and Ophthalmology(ARVO) 2010 Annual Meeting
- Place of Presentation
  Fort Lauderdale, Florida, U. S. A.
- Data Source
  KAKENHI-PROJECT-22791665
[Presentation] Murine Epidermal Cells can be Transdifferentiated into Corneal Epithelial-like Cells in the Corneal Epithelial Environment2010
- Author(s)
  Atsushi Shiraiahi, Takeshi Kobayashi, Yasuhito Hayashi, Yuichi Ohashi
- Organizer
  The Association for Research in Vision and Ophthalmology Annual Meeting
- Place of Presentation
  Fort Lawuderdale, USA
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] 凍結保存細胞によるヒト培養角膜上皮シートの作製2010
- Author(s)
  小林剛、白石敦、楊旅軍、白方裕司、橋本公二、大橋裕一
- Organizer
  第34回角膜カンファランス
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-20791257
[Presentation] Role of HB-EGF in corneal epithelial wound healing2009
- Author(s)
  R.Yoshioka, A.Shiraishi, T.Kobayashi, S.Morita, Y.Hayashi, S.Higashiyama, Y.Ohashi
- Organizer
  Korea Japan Joint Cornea Conference
- Place of Presentation
  京都
- Year and Date
  2009-10-17
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] コラーゲンゲルを用いた角膜上皮培養系における上皮-実質問相互作用の検討2009
- Author(s)
  小林剛, 白石敦, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一
- Organizer
  第8回日本再生医療学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] コラーゲンゲルを用いた三次元上皮培養におけるゲル内実質細胞の増殖因子発現パターン2009
- Author(s)
  小林剛、白石敦、楊旅軍、白方裕司、橋本公二、大橋裕一
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20791257
[Presentation] コラーゲンゲルを用いた三次元上皮培養におけるゲル内実質細胞の増殖因子発現パターン2009
- Author(s)
  小林剛, 白石敦, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一
- Organizer
  第33回角膜カンファランス
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] Role of HB-EGF in Corneal Epithelial Wound healing.2009
- Author(s)
  吉岡龍治, 森田真一, 林康人, 小林剛, 白石敦, 東山繁樹, 大橋裕一
- Organizer
  Korea Japan Joint Cornea Conference 2009
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] HB-EGFはマウス角膜上皮細胞の遊走と接着を促進する2009
- Author(s)
  吉岡龍治, 白石敦, 小林剛, 森田真一, 林康人, 東山繁樹, 大橋裕一
- Organizer
  第33回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] コラーゲンゲルを用いた三次元上皮培養におけるゲル内実質細胞の増殖因子発現パターン2009
- Author(s)
  小林剛, 白石敦, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一
- Organizer
  第33回角膜カンファランス・第25回日本角膜移植学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] コラーゲンゲルを用いた角膜上皮培養系における上皮-実質間相互作用の検討2009
- Author(s)
  小林剛、白石敦、楊旅軍、白方裕司、橋本公二、大橋裕一
- Organizer
  第8回日本再生医療学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20791257
[Presentation] Role of HB-EGF in corneal epithelial wound healing in vivo and in vitro.2008
- Author(s)
  吉岡龍治, 白石敦, 小林剛, 森田真一, 林康人, 東山繁樹, 大橋裕一
- Organizer
  The Association for Research in Vision and Ophthalmology Annual Meeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] コラーゲンゲルを用いた培養ヒト角膜上皮シートの作製とその評価2008
- Author(s)
  小林剛、白石敦、原祐子、門田裕子、楊旅軍、白方裕司、橋本公二、大橋裕一
- Organizer
  第62回日本臨床眼科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20791257
[Presentation] Cultivation of cornea epithelial cells on the collagen gel containing human dermal fibroblasts.2008
- Author(s)
  A.Shiraishi, T.Kobayashi, Y.Kadota, Y.Hara, Y.Shirakata, K.Hashimoto, Y.Ohashi
- Organizer
  Association for Research in Vision and Ophthalmology Annual Meeting
- Place of Presentation
  Fort Lauderdale, USA
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] Cultivation of corneal epithelial cells on the collagen gel containing human dermal fibroblasts2008
- Author(s)
  Atsushi Shiraihi. Takeshi Kobayashi, Yuko Kadota, Yuko Hara, Yuji Shirakata, Koji Hashimoto, Yuichi Ohashi
- Organizer
  視覚と眼科学研究協議会
- Place of Presentation
  アメリカ・フロリダ
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] 眼科再生医療研究会-コラーゲンゲルを用いた培養ヒト角膜上皮シートの作製とその評価2008
- Author(s)
  小林剛, 白石敦, 原祐子, 門田裕子, 楊旅軍, 白方裕司, 橋本公二, 大橋裕一
- Organizer
  第62回日本臨床眼科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] 角膜上皮創傷治癒機転におけるHB-EGFの役割-in vitro検討2008
- Author(s)
  吉岡龍治, 白石敦, 森田真一, 小林剛, 林康人, 東山繁樹, 大橋裕一
- Organizer
  第32回角膜カンファランス・第24回日本角膜移植学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20592079
[Presentation] ジフェニルメタン系下剤（ビサコジル）の新しいドライアイ点眼薬としての可能性
- Author(s)
  小林剛
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  札幌市
- Year and Date
  2015-04-16 – 2015-04-19
- Data Source
  KAKENHI-PROJECT-24592672
[Presentation] 結膜の水輸送に及ぼすジフェニルメタン系下剤（ビサコジル）の影響
- Author(s)
  小林剛、林康人、鎌尾知行、高平尚子、中尾早織、井上智之、白石敦、大橋裕
- Organizer
  第39回日本角膜学会総会
- Place of Presentation
  高知市
- Year and Date
  2015-02-11 – 2015-02-13
- Data Source
  KAKENHI-PROJECT-24592672

1. SHIRAISHI Atsushi (90314963)

# of Collaborated Projects: 4 results

# of Collaborated Products: 41 results
2. OHASHI Yuichi (00116005)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
3. SHIRAKATA Yuji (50226320)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
4. HAYASHI Yasuhito (70314953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 三谷亜里沙 (60648096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 鈴木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Takeshi 小林 剛

Research Projects

Research Products

Co-Researchers

Epithelial-mesenchymal interaction in the tras-differentiation from mouse epidermal cells to corneal epithelial cells

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An examination of factors for transdifferentiation of mouse epidermal sp cells into corneal epithelial cells

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An examination of corneal epithelium reconstruction by transdifferentiation from mouse epidermal cells to corneal epithelial-like cellsPrincipal Investigator

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Identification of stem cell marker of mouse corneal epithelial cell

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Sex Hormone Effect on FGF7 Signaling andApplication for Dry Eye

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Examination of factors involved in transdifferentiation from mouse epidermal cells to corneal epithelial-like cellsPrincipal Investigator

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Transdifferentiation induction of murine epidermal SP cells into corneal epithelial cells.

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Normal tension glaucoma model: Characterization of retinal neuron specific BDNF and cfos knockoutPrincipal Investigator

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[Journal Article] Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival nepithelial cell line.2019

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[Journal Article] Mechanism of Proliferation of Cultured Human Corneal Endothelial Cells.2017

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[Journal Article] Corona sign: manifestation of peripheral corneal epithelial edema as a possible marker of the progression of corneal endothelial dysfunction2016

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[Journal Article] Miraflow, Soft Contact Lens Cleaner, activity against Acanthamoeba spp.2015

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[Journal Article] Miraflow, Soft Contact Lens Cleaner: Activity Against Acanthamoeba Spp.2015

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[Journal Article] Stromaleepithelial interaction study: The effect of corneal epithelial cells on growth factor expression in stromal cells using organotypic culture model2015

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KOBAYASHI Takeshi 小林剛

[Journal Article] Differences between niche cells and limbal stromal cells in　maintenance of corneal limbal stem cells2014