INOUE Takafumi 井上貴史

… Alternative Names

井上貴史イノウエタカシ

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Researcher Number	70380417
Affiliation (based on the past Project Information) *help	2009 – 2011: Kyushu University, 大学病院, 助教 2005 – 2007: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator 活性酸素種 / 分子標的治療薬 / HDAC阻害剤 / SP細胞 / 分子標的治療 / K-ras / I型、II型子宮体癌 / apoptosis / senescence / アポトーシス … More / 子宮体がん / 癌細胞老化死 / Apoptosis / 細胞老化死 / HDAG-I / p21 … More Except Principal Investigator MDM2 / p53 / p21 / ROS / 癌細胞老化 / NECC1 / HDAC inhibitor / Erα / senescence / Cancer / Molecular targeted Therapy / CDK結合領域 / mdm2 / 活性型Ras / ERα / 細胞老化誘導遺伝子 / lq42 / p21CDKインヒビター / 分子標的治療 / エストロゲン受容体α / 絨毛細胞分化 / proline hydroxylase / 細胞老化 / 癌分子標的療法 / MDM2蛋白 / 巨細胞 / トロホブラスト幹細胞 / ノックアウトマウス胎盤 / NECC1遺伝子 / NFIC / -130C/T多型 / シグナロソーム / MDM2型 / 子宮体癌 / NF1C / AHR / SNP / serum IL24 concentration / AhR transcription / AhR -130bp C/T SNP / MDM2 309 G/T SNP / Endometrial cancer / Genome diversity / がん細胞老化 / 悪性腫瘍 / ゲノム創薬 / ドミナント・ネガティブSRF / SRF / トロホブラスト分化 / 海綿層 / 巨細胞層 / ノックアウト Less

子宮内膜細胞の老化逸脱へのゲノム多様性の関与
- Principal Investigator
  
  和氣徳夫
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
婦人科癌幹細胞と細胞老化誘導および活性酸素種に着目した分子標的治療の可能性Principal Investigator
- Principal Investigator
  
  井上貴史
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
不死化能獲得に関与するp53安定化シグナルの解明とその再構築による癌ゲノム創薬
- Principal Investigator
  
  和氣徳夫
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Development of novel molecular-target therapy focus on type I, type II uterine endometrial cancerPrincipal Investigator
- Principal Investigator
  
  INOUE Takafumi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
p21による活性酸素産生系と癌細胞死誘導能との関連の解析Principal Investigator
- Principal Investigator
  
  井上貴史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
絨毛トロホブラストにおけるNECC1シグナル伝達系とその機能の解明
- Principal Investigator
  
  WAKE Norio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyushu University
Molecular targeted therapy by inducing cancer cell senesence
- Principal Investigator
  
  WAKE Norio
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYUSHU UNIVERCITY

All 2012 2011 2010 2009 2007 2006 2004

All Journal Article Presentation

[Journal Article] The Level of ROS and DNA Damage Mediate with the Type of Cell Death, Senescence or Apoptosis2012
- Author(s)
  Takafumi Inoue, Norio Wake
- Journal Title
  
  Senescence
  
  Volume: 1 Pages: 797-806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592455
[Journal Article] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response2011
- Author(s)
  Kato K, Kuhara A, Yoneda T, Inoue T, Takao T, Ohgami T, Dan L, Kuboyama A, Kusunoki S, Takeda S, Wake N
- Journal Title
  
  MolCancer Ther
  
  Volume: 10(8) Pages: 1430-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249075
[Journal Article] Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers.2010
- Author(s)
  Tatsuhiro Ohgami, Takafumi Inoue, et.al.
- Journal Title
  
  Cancer Science 101
  
  Pages: 1387-1395
- Data Source
  KAKENHI-PROJECT-21791562
[Journal Article] Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers2010
- Author(s)
  Ohgami T, Kato K, Kobayashi H, Sonoda K, Inoue T, Yamaguchi S, Yoneda T, Wake N
- Journal Title
  
  Cancer Sci
  
  Volume: 101(6) Pages: 1387-1395
- NAID
  10026593277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659385
[Journal Article] The Level of Reactive Oxygen Species inducedby p21WAF1/CIP1 is critical for the determination of cell fate.2009
- Author(s)
  Takafumi Inoue, et.al.
- Journal Title
  
  Cancer Science 100
  
  Pages: 1275-1283
- Data Source
  KAKENHI-PROJECT-21791562
[Journal Article] The Level of Reactive Oxygen Species induced by p21^<WAF1/CIP1> is critical for the determination of cell fate.2009
- Author(s)
  Takafumi Inoue, et. al.
- Journal Title
  
  Cancer Science 100
  
  Pages: 1275-1283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791562
[Journal Article] Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate2009
- Author(s)
  Inoue T, Kato K, Kato H, Asanoma K, Kuboyama A, Ueoka Y, Yamaguchi S, Ohgami T, Wake N
- Journal Title
  
  Cancer Science 100(7)
  
  Pages: 1275-83
- NAID
  10027192262
- Data Source
  KAKENHI-PROJECT-21659385
[Journal Article] Induction of human endometrial cancer cell senescence through modulation of HIF-1α activity byEGLN12006
- Author(s)
  Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N
- Journal Title
  
  International Journal of Cancer 118
  
  Pages: 1144-1153
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Induction of human endometrial cancer cell senescence through modulation of HIF-1α activity by EGLN12006
- Author(s)
  Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N
- Journal Title
  
  International Journal of Cancer 118,
  
  Pages: 1144-1153
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Activation of STAT3/5 Signal Pathways in Complete Mole and Repression in Choriocarcinoma Cell Lines2006
- Author(s)
  Kato H, Inoue T, Asanoma K, Matsuda T, Yoshikawa Y, Wake N
- Journal Title
  
  Journal of Reproductive Medicine 51
  
  Pages: 41-48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104014
[Journal Article] Retroperitoneal schwannoma bearing at the right vaginal wall.2004
- Author(s)
  Inoue T et al.
- Journal Title
  
  J Obstet Gynaecol Res. 30(6)
  
  Pages: 454-457
- Data Source
  KAKENHI-PROJECT-14104014
[Presentation] 活性化型K-rasとestrogen receptor(ER)が関与する細胞内活性酸素種を介した細胞老化誘導能に関する検討2010
- Author(s)
  井上貴史
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  東京都
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21791562
[Presentation] p21発現に伴う細胞内活性酸素種の変化と癌細胞死誘導能との解析2007
- Author(s)
  井上貴史
- Organizer
  第59回日本産婦人科学会総会
- Place of Presentation
  京都市
- Year and Date
  2007-04-12
- Data Source
  KAKENHI-PROJECT-18791160
[Presentation] 進行子宮頸癌における前斜角筋リジパ節生検術の検討2007
- Author(s)
  井上貴史
- Organizer
  第42回日本婦人科腫瘍学会
- Place of Presentation
  東京都
- Year and Date
  2007-07-12
- Data Source
  KAKENHI-PROJECT-18791160

1. KATO Kiyoko (10253527)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. KOBAYASHI Hiroaki (70260700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 浅野間和夫 (30380413)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 和氣徳夫 (60091584)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. WAKE Norio (50158606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 平川俊夫 (20218770)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 加藤秀則 (60214392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. 松田貴雄 (10304825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. 有馬隆博 (80253532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SONODA Kenzo (30294929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. UEOKA Yosuke (50372743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 谷口秀一 (70452711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 劉格 (50647998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 恒松良祐 (20380529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 高尾知佳 (40612429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 和気徳夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

INOUE Takafumi 井上 貴史

井上 貴史 イノウエ タカシ

Research Projects

Research Products

Co-Researchers

子宮内膜細胞の老化逸脱へのゲノム多様性の関与

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

婦人科癌幹細胞と細胞老化誘導および活性酸素種に着目した分子標的治療の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

不死化能獲得に関与するp53安定化シグナルの解明とその再構築による癌ゲノム創薬

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel molecular-target therapy focus on type I, type II uterine endometrial cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

p21による活性酸素産生系と癌細胞死誘導能との関連の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

絨毛トロホブラストにおけるNECC1シグナル伝達系とその機能の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular targeted therapy by inducing cancer cell senesence

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The Level of ROS and DNA Damage Mediate with the Type of Cell Death, Senescence or Apoptosis2012

Author(s)

Journal Title

Data Source

[Journal Article] Sodium butyrate inhibits the self-renewal capacity of endometrial tumor side-population cells by inducing a DNA damage response2011

Author(s)

Journal Title

Data Source

[Journal Article] Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers.2010

Author(s)

Journal Title

Data Source

[Journal Article] Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers2010

Author(s)

Journal Title

NAID

Data Source

[Journal Article] The Level of Reactive Oxygen Species inducedby p21WAF1/CIP1 is critical for the determination of cell fate.2009

Author(s)

Journal Title

Data Source

[Journal Article] The Level of Reactive Oxygen Species induced by p21^<WAF1/CIP1> is critical for the determination of cell fate.2009

Author(s)

Journal Title

Data Source

[Journal Article] Level of reactive oxygen species induced by p21Waf1/CIP1 is critical for the determination of cell fate2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Induction of human endometrial cancer cell senescence through modulation of HIF-1α activity byEGLN12006

Author(s)

Journal Title

INOUE Takafumi 井上貴史

井上貴史イノウエタカシ