TOYODA Naomi 豊田尚美

… Alternative Names

HOKAIWADO Naomi

外岩戸尚美ホカイワドナオミ

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Researcher Number	70381853
Affiliation (based on the past Project Information) *help	2016: 国立医薬品食品衛生研究所, 変異遺伝部, 非常勤職員 2013: 国立医薬品食品衛生研究所, 変異遺伝部, 非常勤職員 2006: 名古屋市立大学, 大学院医学研究科, 研究員 2005: 名古屋市立大学, 大学院・医学研究科, 研究員
Review Section/Research Field	Except Principal Investigator Risk sciences of radiation and chemicals / Experimental pathology / Risk sciences of radiation/Chemicals
Keywords	Except Principal Investigator トランスジェニックマウス遺伝子突然変異試験 / 生殖細胞突然変異 / 次世代シークエンサー / 環境変異原 / 遺伝子突然変異 / 次世代影響 / ゲノム / 遺伝毒性 / cancer stem cells / steroid hormone … More / androgen / cell culture / Prostate cancer / マイクロアレイ / 可移植腫瘍 / ヌードマウス / トランスジェニック動物 / がん / 前立腺 / siRNA / GSTP / CD133 / ラット / 細胞株 / 前立腺がん / がん幹細胞 / ステロイドホルモン / アンドロゲン / 培養細胞 / 前立腺癌 / DNA損傷 / 突然変異 / DNAポリメラーゼζ / トランスリージョンDNA合成 / 遺伝毒性発がん物質 / 閾値 Less

Studies on quantitative evaluation of inherited germline mutations
- Principal Investigator
  
  Masumura Kenichi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Health Sciences
Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta
- Principal Investigator
  
  NOHMI Takehiko
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  National Institute of Health Sciences
Mechanistic analysis for androgen independent growth of prostate cancers
- Principal Investigator
  
  ASAMOTO Makoto
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya City University

All 2017 2016 2015 2013 2011 2010 2008 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Transgenic rat models for mutagenesis and carcinogenesis2017
- Author(s)
  Nohmi T, Masumura K, Toyoda-Hokaiwado N.
- Journal Title
  
  Genes and Environment
  
  Volume: 39 Issue: 1 Pages: 11-11
- DOI
  10.1186/s41021-016-0072-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25281027, KAKENHI-PROJECT-26281029
[Journal Article] Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice.2016
- Author(s)
  Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
- Journal Title
  
  Genes and Environment
  
  Volume: 38 Issue: 1 Pages: 10-10
- DOI
  10.1186/s41021-016-0035-y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25281027
[Journal Article] Dose-dependent de novo germline mutations detected by whole-exome sequencing in progeny of ENU-treated male gpt delta mice.2016
- Author(s)
  Masumura K,Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
- Journal Title
  
  Mutation Research
  
  Volume: 810 Pages: 30-39
- DOI
  10.1016/j.mrgentox.2016.09.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25281027
[Journal Article] Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats2011
- Author(s)
  N. Toyoda-Hokaiwado
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Issue: 10 Pages: 1512-1517
- DOI
  10.1093/carcin/bgr130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-23380120
[Journal Article] Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats : in vivo mutagenicity of 2,4-diaminotoluene and 2,6-dianimotoluene structural isomers2010
- Author(s)
  N Toyoda-Hokaiwado
- Journal Title
  
  Toxicol.Sci.
  
  Volume: 114 Pages: 71-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016
[Journal Article] Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats : in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers2010
- Author(s)
  N Toyoda-Hokaiwado, T. Inoue, K. Masumura, H. Hayashi, Y. Kawamura, Y. Kurata, M. Takamune, M. Yamada, H. Sanada, T. Umemura, A. Nishikawa and T. Nohmi
- Journal Title
  
  Toxicol. Sci.
  
  Volume: 114 Issue: 1 Pages: 71-78
- DOI
  10.1093/toxsci/kfp306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22241016
[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells2008
- Author(s)
  Hokaiwado, N., Takeshita, F., Naiki-Ito, A., Asamoto, M., Ochiya, T., Shirai, T
- Journal Title
  
  Carcinogenesis., Epub ahead of print
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells.2008
- Author(s)
  Hokaiwado, N.
- Journal Title
  
  Carcinogenesis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells2008
- Author(s)
  Hokaiwado, N
- Journal Title
  
  Carcinogenesis (Epub ahead of print)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells2007
- Author(s)
  Tang, M., Ogawa, K., Asamoto, M., Hokaiwado, N., Azman, S., Suzuki, S., Takahashi, S., Tanaka, T., Ichikawa, K., Shirai, T
- Journal Title
  
  Cancer Sc 98
  
  Pages: 471-477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Limited effects of disrupted Gap Junctions in the liver on multi-organ carcinogenesis induced by Diisopropanolnitrosamine in the mutant Connexin 32 Transgenic rat2006
- Author(s)
  Murasaki, T., Asamoto, M., Hokaiwado, N., Ogawa, K., Shirai, T
- Journal Title
  
  J Toxicol Pathol 19
  
  Pages: 93-97
- NAID
  130000065694
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist2006
- Author(s)
  Said, M., Hokaiwado, N., Tang, M., Ogawa, K., Suzuki, S., Ghanem, H. N., Esmat, A. Y., Asamoto, M., Fawzia, M. R., Shirai, T
- Journal Title
  
  Cancer Sci 97
  
  Pages: 459-467
- NAID
  10018176080
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells2006
- Author(s)
  Tsujimura, K., Asamoto, M., Shugo, S., Hokaiwado, N., Ogawa, K., Shirai, T
- Journal Title
  
  Cancer Sci 97
  
  Pages: 1002-1010
- NAID
  10019377814
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Transgenic disruption of gap junctional intercellular communication protects against hepatotoxicity while increasing susceptibility to liver carcinogenesis in rats, in Carcinogenesis and Modification of Carcinogenesis2005
- Author(s)
  Asamoto, M., Hokaiwado, N., Shirai, T
- Journal Title
  
  Edited by T. Tanaka, H. Tsuda. Kerala, Research Signpost
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Transgenic disruption of gap junction enhances early but not late stage hepatocarcinogenesis in the rat.2005
- Author(s)
  Hokaiwado, N.
- Journal Title
  
  Toxicol.Pathol. 33・6
  
  Pages: 695-701
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Harman and norharman suppressed but NaNO2 enhanced the development of preneoplastic liver cell foci in 2-amino-3, 8-dimethylimidazo[4,5-f] quinoxaline (MeIQx)-reated rats2005
- Author(s)
  Sugiura, S., Asamoto, M., Hokaiwado, N., Hirose, M., Shirai, T
- Journal Title
  
  J., Toxicol. Pathol 18
  
  Pages: 99-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Journal Article] Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells2005
- Author(s)
  Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Shirai, T
- Journal Title
  
  Cancer Lett 219
  
  Pages: 105-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Presentation] Analysis of inherited germline mutations of ENU-treated mice by whole exome sequencing2016
- Author(s)
  Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
- Organizer
  Society of Toxicology 55th Annual meeting
- Place of Presentation
  New Orleans Ernest N. Morial Convention Center, LA, USA
- Year and Date
  2016-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] Estimation of the frequency of inherited germline mujtations by whole-exome sequencing in ethylnitrosourea-treated gpt delta mice2016
- Author(s)
  Masumura K, Toyoda-Hokaiwado N, Ukai A, Gondo Y, Honma M, Nohmi T
- Organizer
  47th Annual Meeting of Environmental Mutagenesis and Genomics Society
- Place of Presentation
  Westin Kansas City at Crown center
- Year and Date
  2016-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] 全エキソーム解析を用いたENU 投与雄マウスの次世代個体における生殖細胞系列突然変異頻度の測定2016
- Author(s)
  増村健一，鵜飼明子，豊田尚美，権藤洋一，能美健彦，本間正充
- Organizer
  日本環境変異原学会第45回大会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] マウス全エキソーム解析によるENU誘発生殖細胞変異スペクトルの解析2015
- Author(s)
  増村健一、鵜飼明子、豊田尚美、権藤洋一、能美健彦、本間正充
- Organizer
  日本環境変異原学会第44回大会
- Place of Presentation
  九州大学馬出キャンパス
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] Spontaneous point mutations and deletions increased with aging in gpt delta transgenic mice and rats2013
- Author(s)
  K. Masumura, N. Toyoda-Hokaiwado, N. Osugi, Y. Ishii, T. Umemura, H. Takagi, A. Nishikawa, T. Nohmi and M. Honma
- Organizer
  11th International Conference on Environmental Mutagens
- Place of Presentation
  Iguacu, Brazil
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] gpt deltaラットを用いた反復投与毒性・遺伝毒性の包括的試験法の妥当性について2013
- Author(s)
  赤木純一，チョウ・ヨンマン，豊田武士，大波冴子，水田保子，鈴木勇，能美健彦，西川秋佳，小川久美子
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] gpt deltaラット肝臓における自然突然変異および加齢に伴う変異蓄積の検討2013
- Author(s)
  増村健一，豊田尚美，石井雄二，梅村隆志，能美健彦，西川秋佳，本間正充
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] Spontaneous point mutations and deletions increased with aging in gpt delta transgenic mice and rats2013
- Author(s)
  Masumura K, Toyoda-Hokaiwado N, Osugi N, Ishii Y, Umemura T, Takagi H, Nishikawa A, Nohmi T, Honma M
- Organizer
  11th International Conference on Environmental Mutagens
- Place of Presentation
  Bourbon Cataratas Convention & Spa Resort, Foz do Iguazu, Brazil
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] gpt deltaマウスを用いたENU誘発突然変異と全エクソンシークエンスによる経世代変異の検出2013
- Author(s)
  増村健一，豊田尚美，権藤洋一，能美健彦，本間正充
- Organizer
  日本環境変異原学会第42回大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] gpt deltaマウスを用いたENU誘発突然変異と全エクソンシークエンスによる経世代変異の検出2013
- Author(s)
  増村健一，豊田尚美，権藤洋一，能美健彦，本間正充
- Organizer
  日本環境変異原学会第42回大会
- Place of Presentation
  岡山コンベンションセンター（岡山県岡山市）
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] Genotoxic thresholds : identification of mutations in vivo and mechanistic studies in vitro2011
- Author(s)
  T. Nohmi, K. Masumura, P Gruz, N. Toyoda-Hokaiwado, M. Takamune, N. Niimi, T. Suzuki, Y. Kanemaru, M. Yasui, M. Yamada, M. Honma, N. Adachi and A. Nishikawa
- Organizer
  2nd International Symposium on Genotoxic and Carcinogenic Thresholds
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] gpt delta transgenic ratにおけるシリマリンの化学予防効果2011
- Author(s)
  豊田尚美
- Organizer
  第27回日本毒性病理学会総会
- Place of Presentation
  大阪
- Year and Date
  2011-01-28
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] gpt delta transgenic ratにおける化学発がんに対するカプサイシンとシリマリンの化学予防効果2010
- Author(s)
  豊田尚美
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-22241016
[Presentation] Establishment and characterization of rat prostate carcinoma cell lines derived from the Probasin/SV40Tag transgenic rat model2007
- Author(s)
  Asamoto, M., Hokaiwado, N., Shirai, T
- Organizer
  Proceedings of the 18th Workshop on Prostate Cancer
- Place of Presentation
  Tokyo
- Year and Date
  2007-09-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590356
[Presentation] gpt deltaラットの加齢により誘発される点突然変異および欠失変異の解析
- Author(s)
  増村健一，豊田尚美，石井雄二，梅村隆志，能美健彦，西川秋佳，本間正充
- Organizer
  第37回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] マウス全エクソンシークエンス解析による経世代突然変異の測定
- Author(s)
  増村健一，豊田尚美，権藤洋一，能美健彦，本間正充
- Organizer
  日本環境変異原学会第43回大会
- Place of Presentation
  一橋講堂
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] gpt deltaマウスを用いた加齢に伴い蓄積する遺伝子突然変異の解析
- Author(s)
  増村健一，大杉直弘，豊田尚美，能美健彦，本間正充
- Organizer
  日本進化学会第16回大会
- Place of Presentation
  高槻現代劇場
- Year and Date
  2014-08-21 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25281027
[Presentation] Point mutations and deletions induced by aging in liver of gpt delta transgenic rats
- Author(s)
  Masumura K, Toyoda-Hokaiwado N, Ishii Y, Umemura T, Honma M, Nishikawa A, Nohmi T
- Organizer
  4th Asian Conference on Environmental Mutagens
- Place of Presentation
  CSIR-Indian Institute of Chemical Biology, Kolkata, India
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25281027

1. NOHMI Takehiko (30150890)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
2. MASUMURA Kenichi (40291116)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
3. YASUI Manabu (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SAJI Tetsuya (20573950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. GRUZ Petr (10321853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. ASAMOTO Makoto (50212494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. HONMA Masamitsu (30250179)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
8. 権藤洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TOYODA Naomi 豊田 尚美

HOKAIWADO Naomi

外岩戸 尚美 ホカイワド ナオミ

Research Projects

Research Products

Co-Researchers

Studies on quantitative evaluation of inherited germline mutations

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanistic analysis for androgen independent growth of prostate cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transgenic rat models for mutagenesis and carcinogenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dose-dependent de novo germline mutations detected by whole-exome sequencing in progeny of ENU-treated male gpt delta mice.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemopreventive effects of silymarin against 1,2-dimethylhydrazine plus dextran sodium sulfate-induced inflammation-associated carcinogenicity and genotoxicity in the colon of gpt delta rats2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats : in vivo mutagenicity of 2,4-diaminotoluene and 2,6-dianimotoluene structural isomers2010

Author(s)

Journal Title

Data Source

[Journal Article] Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats : in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers2010

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Glutathione S-transferase pi mediates proliferation of androgen independent prostate cancer cells2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Limited effects of disrupted Gap Junctions in the liver on multi-organ carcinogenesis induced by Diisopropanolnitrosamine in the mutant Connexin 32 Transgenic rat2006

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist2006

Author(s)

TOYODA Naomi 豊田尚美

外岩戸尚美ホカイワドナオミ