Nonoguchi Naosuke 野々口直助

… Alternative Names

NONOGUCHI Naosuke 野々口直助

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Researcher Number	70388263
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪医科薬科大学, 医学部, 講師 2016 – 2020: 大阪医科大学, 医学部, 講師 2017: 大阪医科大学, 医学部, その他 2014 – 2016: 大阪医科大学, 医学部, 助教 2011: 大阪医科大学, 医学部, 助教 … More 2008 – 2010: Osaka Medical College, 医学部, 非常勤講師 2007: 大阪医科大学, 医学部, 助教 2005 – 2006: 大阪医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Basic Section 56010:Neurosurgery-related / Neurosurgery Except Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery / Cerebral neurosurgery / Applied health science / Radiation science
Keywords	Principal Investigator FGF-2 / 脳梗塞 / 腫瘍幹細胞 / グリオーマ / キメラ転写産物 / 浸潤脳 / 増殖能 / 低酸素 / 融合転写産物 / 悪性髄膜種 … More / 悪性グリオーマ / 悪性髄膜腫 / 悪性神経膠腫 / キメラRNA / 融合遺伝子 / 転写キメラ / バイオマーカー / メトトレキセート / 中枢神経系原発悪性リンパ種 / 分子マーカー / 化学療法単独治療 / 悪性リンパ腫 / nonsense mutation / methotrexate / biomarker / ILDR2 / BCL6 / mutation / BTG2 / complete remission / methotrexate monotherapy / PCNSL / 移植幹細胞 / 骨髄感細胞 / 移植 / Erythropoietin / 低酸素負荷 / 分化誘導 / 骨髄間葉系幹細胞 / 錐体神経細胞 / 幹細胞移植 / 神経再生 / 分化転換 / 神経分化 / 骨髄幹細胞 / 脳虚血 / VEGF / HGF / 単純ヘルペスウイルスベクター / 骨髄間葉系細胞 / 神経保護 / 血管内皮細胞成長因子 / 線維芽細胞成長因子 / 肝細胞成長因子 / 複製不能型単純ヘルペスウイルスベクター / 遺伝子治療 / ラット中大脳動脈閉塞モデル … More Except Principal Investigator ホウ素中性子捕捉療法 / 脳腫瘍 / bevacizumab / BNCT / 神経膠腫 / 悪性神経膠腫 / 浸潤能 / actin / glioma / migration / invasion / ACTA2 / ACTC1 / 悪性脳腫瘍 / 放射線壊死 / 癌 / HGF / FGF / 脳神経疾患 / ベバシズマブ / VEGF / 炎症 / 血管新生 / 脳放射線壊死 / 骨髄細胞 / lamellipodia / T細胞疲弊 / 免疫療法 / 膠芽腫 / ジアシルグリセオールキナーゼ（DGK） / 脊髄神経膠腫 / ACTC-1 / 低酸素暴露 / ACTC1遺伝子 / 悪性髄膜腫 / 葉状仮足形成能 / 細胞遊走能 / ACTC2 / ＣＥＤ / CED法 / CED / 葉酸受容体標的ホウ素化合物 / molecular analysis / carcinoma / prognosis / meningioma / glioblastoma / malignant glioma / recurrence / Pseudoprogression / プロトポルフィリンIX / アミノレブリン酸 / 外部励起光減 / 5-amino levulinic acid / 術中CT / 定位脳生検 / 外部励起光源 / 5-aminolevulinic acid / 光線力学的治療 / 光線力学的診断 / ナビゲーションシステム / 定位的脳生検術 / 5-アミノレブリン酸 / X線 / radiological diagnosis / radiation necrosis / brain tumor / 放射線学的診断 / HIF-1 / 放射線画像診断 / 量子捕獲反応 / 輸送タンパク質 / 放射線 / 輸送タンパク質TSPO / ホウ素中性子捕捉療法(BNCT) / トランスレーショナルリサーチ / 放射線治療 / cerebral ischemia / mesenchymal stromal cell / bone marrow cell / Senescence accelerated mouse / Anti-aging / 老化促進マウス / 脳萎縮 / 骨髄細胞移植 / 老化 / 骨粗しょう症 / 認知症 / 遺伝子導入 / 脳梗塞治療 / 老化予防 / 脳虚血 / 骨髄間葉系幹細胞 / 老化マウス / アンチエイジング / ベﾊﾞｼｽﾞﾏﾌﾞ / 放射線脳壊死 / 再発悪性神経膠腫 / HIF-1阻害剤 / HIF-1 alpha / 血管内皮増殖因子 / HIF-1α / マクロファージ / アストロサイト / 血液脳関門 / Convection enhanced delivery / 光線力学療法 / 中性子捕捉療法 / ポルフィリン / 粒子線治療 / 神経原生 / 遺伝子治療 / 線維芽細胞成長因子 / FGF-2 / 脳卒中 / 脳梗塞 / 脱シアル化 / アシアロエリスロポイエチン / エリスロポイエチン Less

Elucidation of the antitumor effect of diacylglycerol kinase (DGK) inhibition in glioblastoma
- Principal Investigator
  
  矢木亮吉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
グリオーマ浸潤におけるlamellipodiaの解析とα-actinの制御機構の解明
- Principal Investigator
  
  鰐渕昌彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
脊髄神経膠腫に対するホウ素中性子捕捉療法の確立に向けた基盤研究
- Principal Investigator
  
  高見俊宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
悪性神経膠腫・悪性髄膜種において新規分子標的となる転写キメラの同定とその機能解析Principal Investigator
- Principal Investigator
  
  野々口直助
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Elucidation of the relationship between infiltration ability and ACTC1 and its molecular mechanism in malignant meningioma
- Principal Investigator
  
  Yagi Ryokichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Elucidation of pathophysiology of pseudoprogression for brain tumors
- Principal Investigator
  
  Furuse Motomasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Analysis of glioma invasion mechanisms and development of pioneering therapies targeting invasive potential
- Principal Investigator
  
  Wanibuchi Masahiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Investigation regarding the progress of therapeutic effect of BNCT using folate receptor-targeted boron compound which be administered by convection enhanced delivery
- Principal Investigator
  
  Hiramatsu Ryo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Predictive map for PDT effect, malignancy and biological characteristics in malignant brain tumor
- Principal Investigator
  
  Ikeda Naokado
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka Medical College
Translocator protein (TSPO) targetting boron deliverly and neutron capture therapy against malignant brain tumors
- Principal Investigator
  
  Kawabata Shinji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka Medical College
Search for biomarkers of sensitivity to MTX monotherapy in primary central nervous system lymphomaPrincipal Investigator
- Principal Investigator
  
  Nonoguchi Naosuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka Medical College
Novel diagnostic examination and treatment of radiation necrosis based on molecular pathological mechanism
- Principal Investigator
  
  Furuse Motomasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka Medical College
Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy
- Principal Investigator
  
  Miyatake Shin-Ichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka Medical College
Patho-physiology of the radiation necrosis in the brain
- Principal Investigator
  
  MIYATAKE Shinichi
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Osaka Medical College
Usefullness of novel boronated porphyrins for both BNCT and PDT
- Principal Investigator
  
  KAWABATA Shinji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka Medical College
Induction of pyramidal neuronal cells from bone marrow stromal stemcells and application for autologous transplantation against the cerebral infarction.Principal Investigator
- Principal Investigator
  
  NONOGUCHI Naosuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka Medical College
短半減期エリスロポイエチン誘導体とFGF2を用いた神経再生と神経保護の研究
- Principal Investigator
  
  MIYATAKE Shinichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka Medical College
神経栄養遺伝子を導入した骨髄細胞の移植による神経再生と神経保護を目指した研究Principal Investigator
- Principal Investigator
  
  野々口直助
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka Medical College
Regeneration of neurons and vessels using bone marrow cells and gene delivery
- Principal Investigator
  
  KUROIWA Toshihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Osaka Medical College

All 2023 2021 2020 2019 2018 2017 2016 2015 2014 2011 2009 2006 2005

All Journal Article Presentation Book

[Book] 脳神経外科臨床マニュアル　（42章中枢神経系原発悪性リンパ腫の診断と治療）2019
- Author(s)
  端和夫・三國信啓編（分担共著：野々口直助）
- Total Pages
  1041
- Publisher
  丸善出版
- ISBN
  9784621303481
- Data Source
  KAKENHI-PROJECT-17K10880
[Journal Article] Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model2023
- Author(s)
  Fujikawa Yoshiki、Fukuo Yusuke、Nishimura Kai、Tsujino Kohei、Kashiwagi Hideki、Hiramatsu Ryo、Nonoguchi Naosuke、Furuse Motomasa、Takami Toshihiro、Hu Naonori、Miyatake Shin-Ichi、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Suzuki Minoru、Kawabata Shinji、Nakamura Hiroyuki、Wanibuchi Masahiko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 9 Pages: 1240-1240
- DOI
  10.3390/biology12091240
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09270, KAKENHI-PROJECT-23K27715
[Journal Article] Improved Boron Neutron Capture Therapy Using Integrin αvβ3-Targeted Long-Retention-Type Boron Carrier in a F98 Rat Glioma Model2023
- Author(s)
  Tsujino Kohei、Kashiwagi Hideki、Nishimura Kai、Kayama Ryo、Yoshimura Kohei、Fukuo Yusuke、Shiba Hiroyuki、Hiramatsu Ryo、Nonoguchi Naosuke、Furuse Motomasa、Takami Toshihiro、Miyatake Shin-Ichi、Hu Naonori、Takata Takushi、Tanaka Hiroki、Suzuki Minoru、Kawabata Shinji、Nakamura Hiroyuki、Wanibuchi Masahiko
- Journal Title
  
  Biology
  
  Volume: 12 Issue: 3 Pages: 377-377
- DOI
  10.3390/biology12030377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16698, KAKENHI-PROJECT-20H03797, KAKENHI-PROJECT-22K09270
[Journal Article] Radiological diagnosis of brain radiation necrosis after cranial irradiation for brain tumor: a systematic review2019
- Author(s)
  Furuse Motomasa、Nonoguchi Naosuke、Yamada Kei、Shiga Tohru、Combes Jean-Damien、Ikeda Naokado、Kawabata Shinji、Kuroiwa Toshihiko、Miyatake Shin-Ichi
- Journal Title
  
  Radiation Oncology
  
  Volume: 14 Issue: 1 Pages: 28-28
- DOI
  10.1186/s13014-019-1228-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10877, KAKENHI-PROJECT-17K10911
[Journal Article] Folate receptor-targeted novel boron compound for boron neutron capture therapy on F98 glioma-bearing rats2018
- Author(s)
  Kanemitsu Takuya、Kawabata Shinji、Fukumura Masao、Futamura Gen、Hiramatsu Ryo、Nonoguchi Naosuke、Nakagawa Fumiko、Takata Takushi、Tanaka Hiroki、Suzuki Minoru、Masunaga Shin-Ichiro、Ono Koji、Miyatake Shin-Ichi、Nakamura Hiroyuki、Kuroiwa Toshihiko
- Journal Title
  
  Radiation and Environmental Biophysics
  
  Volume: 58 Issue: 1 Pages: 59-67
- DOI
  10.1007/s00411-018-0765-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10877, KAKENHI-PROJECT-17K10878, KAKENHI-PROJECT-15H04295, KAKENHI-PROJECT-17H02202
[Journal Article] Radiation necrosis after cranial irradiation for brain tumors2018
- Author(s)
  古瀬　元雅、野々口　直助、池田　直廉、川端　信司、宮武　伸一、黒岩　敏彦
- Journal Title
  
  Progress in Neuro-Oncology
  
  Volume: 25 Issue: 1 Pages: 23-32
- DOI
  10.11452/neurooncology.25.1_23
- NAID
  130006728649
- ISSN
  1880-0742, 2187-0551
- Year and Date
  2018-04-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10911
[Journal Article] Boron Neutron Capture Therapy Combined with Early Successive Bevacizumab Treatments for Recurrent Malignant Gliomas ? A Pilot Study2018
- Author(s)
  SHIBA Hiroyuki、TAKEUCHI Koji、HIRAMATSU Ryo、FURUSE Motomasa、NONOGUCHI Naosuke、KAWABATA Shinji、KUROIWA Toshihiko、KONDO Natsuko、SAKURAI Yoshinori、SUZUKI Minoru、ONO Koji、OUE Shiro、ISHIKAWA Eiichi、MICHIUE Hiroyuki、MIYATAKE Shin-Ichi
- Journal Title
  
  Neurologia medico-chirurgica
  
  Volume: 58 Issue: 12 Pages: 487-494
- DOI
  10.2176/nmc.oa.2018-0111
- NAID
  130007531206
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10877, KAKENHI-PROJECT-17K10878, KAKENHI-PROJECT-17K10911, KAKENHI-PROJECT-18K07324, KAKENHI-PROJECT-18K08944
[Journal Article] A prospective, multicentre, single-arm clinical trial of bevacizumab for patients with surgically untreatable, symptomatic brain radiation necrosis2016
- Author(s)
  Furuse M, Nonoguchi N, Kuroiwa T, Miyamoto S, Arakawa Y, Shinoda J, Miwa K, Iuchi T, K, Houkin K, Terasaka S, Tabei Y, Nakamura H, Nagane M, Sugiyama K, Terasaki M, Abe T, Narita Y, Saito N, Mukasa A, Ogasawara K, Beppu T, Kumabe T, Nariai T, Tsuyuguchi N, Nakatani E, Kurisu S, Naakagawa Y, Miyatake S.
- Journal Title
  
  Neuro-Oncology Practice
  
  Volume: 0 Issue: 4 Pages: 1-9
- DOI
  10.1093/nop/npv064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25462281, KAKENHI-PROJECT-16H05387, KAKENHI-PROJECT-26293321, KAKENHI-PROJECT-26293327, KAKENHI-PROJECT-16K15573
[Journal Article] Pathophysiology, Diagnosis, and Treatment of Radiation Necrosis in the Brain2015
- Author(s)
  Shin-Ichi Miyatake, Noasuke Nonoguchi, Motomasa Furuse, Erina Yoritsune, Tomo Miyata, Shinji Kawabata, and Toshihiko Kuroiwa
- Journal Title
  
  Neurol. Med. Chir.(Tokyo)
  
  Volume: 55 Issue: 1 Pages: 50-59
- DOI
  10.2176/nmc.ra.2014-0188
- NAID
  130004922267
- ISSN
  0470-8105, 1349-8029
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293327, KAKENHI-PROJECT-26462192, KAKENHI-PROJECT-26462222
[Journal Article] 症候性脳放射線壊死の核医学的診断とベバシズマブによる治療（先進医療Bからの薬事承認に向けて）2015
- Author(s)
  宮武伸一、古瀬元雅、野々口直助、川端信司、黒岩敏彦
- Journal Title
  
  脳神経外科ジャーナル
  
  Volume: 24(6) Pages: 399-406
- NAID
  130005083634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293327
[Journal Article] Delayed brain radiation necrosis: pathological review and new molecular targets for treatment2015
- Author(s)
  Furuse　M.,　Nonoguchi　N.,　Kawabata　S., Miyatake S., Kuroiwa T
- Journal Title
  
  Med Mol Morphol
  
  Volume: 48(4) Issue: 4 Pages: 183-190
- DOI
  10.1007/s00795-015-0123-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293327
[Journal Article] Intratumoral and peritumoral post-irradiation changes, but not viable tumor.2015
- Author(s)
  Furuse M, Nonoguchi N, Kawabata S, Miyata T, Toho T, Kuroiwa T, Miyatake S.
- Journal Title
  
  Radiat Oncol.
  
  Volume: 10 Issue: 1 Pages: 156-156
- DOI
  10.1186/s13014-015-0446-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462192, KAKENHI-PROJECT-26462222, KAKENHI-PROJECT-26293327
[Journal Article] 脳放射線壊死とミクログリア2015
- Author(s)
  野々口　直助、古瀬　元雅、宮武　伸一
- Journal Title
  
  Clinical Neuroscience 月刊　臨床神経科学
  
  Volume: VOL.33,12 Pages: 1377-1381
- Data Source
  KAKENHI-PROJECT-26293327
[Journal Article] Inflammation as well as angiogenesis may participate in the pathophysiology of brain radiation necrosis.2014
- Author(s)
  Yoritsune E, Furuse M, Kuwabara H, Miyata T, Nonoguchi N, Kawabata S, Hana Hayasaki H, Kuroiwa T, Ono K, Shibayama Y, and Miyatake S
- Journal Title
  
  J Radiat Res
  
  Volume: 55(4) Issue: 4 Pages: 803-11
- DOI
  10.1093/jrr/rru017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293327, KAKENHI-PROJECT-26462192, KAKENHI-PROJECT-26462222
[Journal Article] The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain. - Pathological consideration of their potential roles2011
- Author(s)
  Nonoguchi N
- Journal Title
  
  J Neuro-Oncol
  
  Volume: 105 Issue: 2 Pages: 423-431
- DOI
  10.1007/s11060-011-0610-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390355, KAKENHI-PROJECT-23659596
[Journal Article] Boron neutron capture therapy for newly diagnosed glioblastoma.2009
- Author(s)
  Kawabata S, Miyatake S, Kuroiwa T,Yokoyama K, Doi A, Iida K, Miyata S,Nonoguchi N, Michiue H, Takahashi M,Inomata T, Imahori Y, Kirihata M, Sakurai Y,Maruhashi A, Kumada H, Ono K
- Journal Title
  
  J Radiat Res(Tokyo). 50
  
  Pages: 51-60
- NAID
  110007042075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591728
[Journal Article] Novel therapeutic strategy for stroke in rats by bone marrow stromal cells and ex vivo HGF gene transfer with HSV- 1 vector.2006
- Author(s)
  Ming-Zhu Zhao, Naosuke Nonoguchi, et al.
- Journal Title
  
  J Cereb Blood Flow Metab. 26
  
  Pages: 1176-1188
- Data Source
  KAKENHI-PROJECT-17790989
[Journal Article] Novel Therapeutic Strategy for Stroke in Rats by Bone Marrow Stromal Cells and Ex Vivo HGF Gene Transfer with HSV-1 Vector2006
- Author(s)
  M Zhao, N Nonoguchi, N Ikeda, T Watanabe, D Furutama, D Miyazawa, H Funakoshi, Y Kajimoto, T Nakamura, M Dezawa, M Shibata, Y Otsuki, RS. Coffin, W Liu, T Kuroiwa, S Miyatake
- Journal Title
  
  J Cereb Blood Flow Metab 26・9
  
  Pages: 1176-1188
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300224
[Journal Article] Novel Therapeutic Strategy for Stroke in Rats by Bone Marrow Stromal Cells and Ex Vivo HGF Gene Transfer with HSV-1 Vector.2006
- Author(s)
  Zhao-MZ, Nonoguchi N, Miyatake S, et al.
- Journal Title
  
  Journal of cerebral blood flow and metabolism 26
  
  Pages: 1176-1188
- Data Source
  KAKENHI-PROJECT-18659429
[Journal Article] Novel Therapeutic Strategy for Stroke in Rats by Bone Marrow Stromal Cells and Ex Vivo HGF Gene Transfer with HSV-1 Vector2006
- Author(s)
  M Zhao, N Nonoguchi, N Ikeda, T Watanabe, D Furutama, D Miyazawa, H Funakoshi, Y Kajimoto, T Nakamura, M Dezawa, M Shibata, Y Otsuki, RS. Coffin, W Liu, T Kuroiwa, S Miyatake
- Journal Title
  
  J Cereb Blood Flow Metab 26 (9)
  
  Pages: 1176-1188
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300224
[Journal Article] Novel Therapeutic Strategy for Stroke in Rats by Bone Marrow Stromal Cells and Ex Vivo HGF Gene Transfer with HSV-1 Vector2006
- Author(s)
  M Zhao, N Nonoguchi, N Ikeda, T Watanabe, D Furutama, D Miyazawa, H Funakoshi, Y Kajimoto, T Nakamura, M Dezawa, M Shibata, Y Otsuki, RS.Coffin, W Liu, S Miyatake
- Journal Title
  
  J Cereb Blood Flow Metab 26・9
  
  Pages: 1176-1188
- Data Source
  KAKENHI-PROJECT-17300224
[Journal Article] 脳梗塞に対する骨髄間質細胞移植治療と神経保護活性を有するサイトカイン遺伝子治療の融合2006
- Author(s)
  野々口直助, 宮武伸一
- Journal Title
  
  分子脳血管病 5
  
  Pages: 449-456
- Data Source
  KAKENHI-PROJECT-18659429
[Journal Article] Bone Marrow Stromal Cells That Enhanced FGF-2 Secretion by Herpes Simplex Virus Vector Improve Neurological Outcome after Transient Focal Cerebral Ischemia in Rats.2005
- Author(s)
  Ikeda N, Nonoguchi N, Zhao MZ, Watanabe T, Kajimoto Y, Furutama D, Kimura F, Dezawa M, Robert S, Otsuki Y, Kuroiwa T, Miyatake SI
- Journal Title
  
  Stroke 36・12
  
  Pages: 2725-2730
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17300224
[Journal Article] Bone Marrow Stromal Cells That Enhanced FGF-2 Secretion by Herpes Simplex Virus Vector Improve Neurological Outcome after Transient Focal Cerebral Ischemia in Rats.2005
- Author(s)
  Ikeda N, Nonoguchi N, Zhao MZ, Watanabe T, Kajimoto Y, Furutama D, Kimura F, Dezawa M, Robert S, Otsuki Y, Kuroiwa T, Miyatake SI
- Journal Title
  
  Stroke 36 (12)
  
  Pages: 2725-2730
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17300224
[Journal Article] Bone marrow stromal cells that enhanced fibroblast growth factor-2 secretion by herpes simplex virus vector improve neurological outcome after transient focal cerebral ischemia in rats.2005
- Author(s)
  Naokado Ikeda, Naosuke Nonoguchi, et wl
- Journal Title
  
  J Cereb Blood Flow Metab. 24・11
  
  Pages: 1205-1213
- Data Source
  KAKENHI-PROJECT-17790989
[Journal Article] Bone Marrow Stromal Cells That Enhanced FGF-2 Secretion by Herpes Simplex Virus Vector Improve Neurological Outcome after Transient Focal Cerebral Ischemia in Rats2005
- Author(s)
  Ikeda N, Nonoguchi N, Miyatake S, et al.
- Journal Title
  
  Stroke 36
  
  Pages: 2725-2730
- Data Source
  KAKENHI-PROJECT-18659429
[Presentation] 髄膜腫の増殖能・浸潤能に関与する可能性がある遺伝子「ACTC1」の発現の検討2023
- Author(s)
  小坂拓也、野々口直助、矢木亮吉、平松亮、亀田雅博、古瀬元雅、川端信司、宮武伸一、鰐渕昌彦
- Organizer
  第83回日本脳神経外科学会近畿支部学術集会
- Data Source
  KAKENHI-PROJECT-20K09359
[Presentation] 腫瘍遊走能に関与する可能性がある遺伝子Actin Alpha Cardiac Muscle 1（ACTC1）の髄膜腫における発現の検討2021
- Author(s)
  小坂拓也、野々口直助、矢木亮吉、平松亮、池田直廉、古瀬元雅、川端信司、宮武伸一、鰐渕昌彦
- Organizer
  第21回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-20K09359
[Presentation] 当院での経鼻内視鏡頭蓋底手術における頭蓋底再建法とその役割-縫合手技の再考ー2021
- Author(s)
  小坂拓也、池田直廉、金光拓也、矢木亮吉、辻優一郎、木村誠吾、古瀬元雅、野々口直助、川端信司、鰐渕昌彦
- Organizer
  第30回脳神経外科手術と機器学会(CNTT)
- Data Source
  KAKENHI-PROJECT-20K09359
[Presentation] 腫瘍遊走能に関与する可能性がある遺伝子「ACTC1」の髄膜腫における発現の検討2021
- Author(s)
  小坂拓也、野々口直助、矢木亮吉、平松亮、池田直廉、古瀬元雅、川端信司、宮武伸一、廣瀬善信、鰐渕昌彦
- Organizer
  第39回日本脳腫瘍病理学会（WEB開催）
- Data Source
  KAKENHI-PROJECT-20K09359
[Presentation] 脳腫瘍に対する外視鏡による術中蛍光ガイド下手術の有用性と問題点2020
- Author(s)
  池田直廉古瀬元雅矢木亮吉金光拓也福村匡央野々口直助川端信司鰐渕昌彦
- Organizer
  第16回日本脳神経外科光線力学学会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] 悪性脳腫瘍に対する術中蛍光診断における蛍光観察システムの変遷と問題点の克服2020
- Author(s)
  池田直廉川端信司片山義英古瀬元雅野々口直助矢木亮吉塩山高広梶本宜永黒岩敏彦鰐渕昌彦
- Organizer
  日本蛍光ガイド手術研究会第3回学術集会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] マルチモダリティ支援ナビゲーションシステム誘導下生検の有用性に関する検討2020
- Author(s)
  池田直廉川端信司矢木亮吉辻優一郎金光拓也木村誠吾野々口直助古瀬元雅黒岩敏彦鰐渕昌彦
- Organizer
  第79回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] グリオーマの放射線壊死鑑別に有用な画像診断 -systematic reviewのサブ解析より-2019
- Author(s)
  古瀬　元雅、野々口　直助、山田　惠、志賀　哲、Jean-Damien Combes，池田　直廉、川端　信司、鰐渕　昌彦、黒岩　敏彦、宮武　伸一
- Organizer
  第37回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] 悪性脳腫瘍に対する5-アミノレブリン酸を用いた術中蛍光診断における問題点克服のための工夫2019
- Author(s)
  池田直廉川端信司片山義英古瀬元雅　野々口直助矢木亮吉塩山高広梶本宜永黒岩敏彦鰐渕昌彦
- Organizer
  第15回日本脳神経光線力学学会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] 悪性脳腫瘍に対する5-アミノレブリン酸を用いた術中蛍光診断における問題点克服のための工夫2019
- Author(s)
  池田直廉　川端信司　片山義英　野々口直助　古瀬元雅　矢木亮吉　塩山高広梶本宜永黒岩敏彦
- Organizer
  第2回蛍光ガイド手術研究会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] ホウ素中性子捕捉療法におけるPET検査を用いたホウ素集積可視化の臨床的意義2019
- Author(s)
  川端信司、宮武伸一、松下葉子、平松亮、野々口直助、古瀬元雅、田中浩基、鈴木実、小野公二
- Organizer
  日本脳神経外科学会第78回学術総会
- Data Source
  KAKENHI-PROJECT-17K10878
[Presentation] The efficacy of Navigation-system Guided Biopsy with 5-ALA Induced Photodynamic Diagnosis for Malignant Brain Tumors2019
- Author(s)
  Naokado Ikeda, Shinji Kawabata, Yoshihide Katayama, Motomasa Furuse, Ryokichi Yagi, Naosuke Nonoguchi, Ryo Hiramatsu, Toshihiko Kuroiwa and Masahiko Wanibuchi
- Organizer
  Congress of Neurosurgeons 2019 annual meeting
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] 5-aminolevulinic acid can sensitize malignant glioma to boronophenylalanine-based boron neutron capture therapy2018
- Author(s)
  Masao Fukumura, Naosuke Nonoguchi, Shinji Kawabata, Gen Futamura, Koji Takeuchi, Takuya Kanemitsu, Takushi Takata, Minoru Suzuki, Oltea Sampetrean, Hideyuki Saya, Shin-ichi Miyatake, Toshihiko Kuroiwa
- Organizer
  18th International Congress on Neutron Capture Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10878
[Presentation] 脳腫瘍に対するマルチモダリティ併用ナビゲーション単独ガイド生検術の有用性2018
- Author(s)
  蒲原明宏, 池田直廉, 川端信司, 片山義英, 福村匡央, 古瀬元雅, 野々口直助, 黒岩敏彦
- Organizer
  第73回脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] 5-ALA光線力学的診断併用ナビゲーションシステム誘導脳針生検の有用性の検討2018
- Author(s)
  福村匡央　池田直廉　川端信司片山義英　古瀬元雅　野々口直助　黒岩敏彦
- Organizer
  第18回日本術中画像情報学会
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] Bevacizumab holidayは可能か？初発膠芽腫に対するbevacizumab治療2018
- Author(s)
  古瀬　元雅、川端　信司、池田　直廉、野々口　直助、宮武　伸一、黒岩　敏彦
- Organizer
  日本脳神経外科学会　第77回学術総会
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] The Efficacy of pure Navigation-system Guided Biopsy with 5-ALA Induced Photodynamic Diagnosis for Malignant Brain Tumors2018
- Author(s)
  Ikeda Naokado, Kawabata Shinji, Katayama Yoshihide, Fukumura Masao, Furuse Motomasa, Nonoguchi Naosuke, Kuroiwa Toshihiko
- Organizer
  第56回日本癌治療学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09011
[Presentation] Bevacizumab holidayは可能か？初発膠芽腫に対するbevacizumab治療2018
- Author(s)
  古瀬　元雅、川端　信司、池田　直廉、野々口　直助、黒岩　敏彦
- Organizer
  第56回日本癌治療学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] 原子炉を中性子源としたホウ素中性子捕捉療法による悪性神経膠腫の治療成績と加速器中性子源への移行2017
- Author(s)
  川端信司、宮武伸一、平松亮、二村元、竹内孝治、斯波宏行、金光拓也、松下葉子、池田直廉、野々口直助、古瀬元雅、田中浩基、櫻井良憲、鈴木実、小野公二、黒岩敏彦
- Organizer
  日本脳神経外科学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-17K10878
[Presentation] REACTOR-BASED BORON NEUTRON CAPTURE THERAPY (BNCT) FOR THE PATIENTS WITH RECURRENT MALIGNANT GLIOMA2017
- Author(s)
  S. Kawabata、R. Hiramatsu、Y. Matsushita、G. Futamura、T. Kanemitsu、H. Shiba、K. Takeuchi、N. Nonoguchi、T. Kuroiwa、H. Tanaka、Y. Sakurai、K. Akita、M. Suzuki、K. Ono、S.I. Miyatake
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10878
[Presentation] 放射線壊死の診断　システマティックレビュー2017
- Author(s)
  古瀬　元雅、野々口　直助、山田　惠、志賀　哲、池田　直廉、川端　信司、黒岩　敏彦、宮武　伸一
- Organizer
  日本脳神経外科学会　第76回学術総会
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] ベバシズマブは放射線脳壊死に薬事承認されるか？　 AVAnecro進捗状況の報告2017
- Author(s)
  古瀬　元雅、野々口　直助、川端　信司、黒岩　敏彦、宮武　伸一
- Organizer
  第35回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] Impact of bevacizumab in patients with recurrent glioblastoma and poor performance status.2017
- Author(s)
  Motomasa Furuse, Shinji Kawabata, Naokado Ikeda, Naosuke Nonoguchi, Yoji Tamura, Yoshinaga Kajimoto, Shin-Ichi Miyatake, Toshihiko Kuroiwa
- Organizer
  22nd Annual Meeting of the Society for Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10911
[Presentation] Gene expression landscape including miRNAs　in delayed radiation necrosis of brain2016
- Author(s)
  Miyatake S-I, Toho T, Fujita M, Furuse M,Kawabata S, Kuroiwa T, Nonoguchi N
- Organizer
  21ST ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE　SOCIETY FOR NEURO-ONCOLOGY
- Place of Presentation
  Scottsdale(U.S.A.)
- Year and Date
  2016-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293327
[Presentation] A prospective multicenter single-arm clinical trial of bevacizumab for patients with surgically untreatable symptomatic brain radiation necrosis2015
- Author(s)
  Motomasa Furuse, Naosuke Nonoguchi, Toshihiko Kuroiwa, Eiji Nakatani, Shoko Kurisu, Yoko Nakagawa, Shin-Ichi Miyatake
- Organizer
  20th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology
- Place of Presentation
  San Antonio Marriott Rivercenter, Texas（U..S.A)
- Year and Date
  2015-11-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293327
[Presentation] 再発悪性神経膠腫に対するBNCTとbevacizumabの同時併用療法は新規治療法になりうるか？2014
- Author(s)
  宮武伸一、川端信司、平松　亮、古瀬元雅、野々口直助、黒岩敏彦、鈴木　実、近藤夏子、櫻井良憲、小野公二
- Organizer
  日本脳神経外科学会　第７3回学術総会シンポジウム
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区）
- Year and Date
  2014-10-10
- Data Source
  KAKENHI-PROJECT-26293327
[Presentation] 再発悪性神経膠腫に対するBNCTとbevacizumabの同時併用療法は新規治療法になりうるか？2014
- Author(s)
  宮武伸一、川端信司、平松　亮、古瀬元雅、野々口直助、黒岩敏彦、鈴木　実、近藤夏子、櫻井良憲、小野公二
- Organizer
  第32回日本脳腫瘍学会
- Place of Presentation
  シェラトングランデトーキョーベイホテル（千葉県浦安市）
- Year and Date
  2014-12-01
- Data Source
  KAKENHI-PROJECT-26293327
[Presentation] 骨髄間葉系幹細胞の神経細胞分化誘導における酸素濃度およびグルコース濃度が与える影響2009
- Author(s)
  野々口直助
- Organizer
  2009年日本脳神経外科学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20791019
[Presentation] 骨髄間葉系幹細胞の神経分化誘導において低酸素および低グルコース濃度が与える影響についての検討2009
- Author(s)
  野々口直助
- Organizer
  第68回日本神経外科学会総会
- Place of Presentation
  東京/京王プラザホテル
- Year and Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20791019

1. KAWABATA Shinji (20340549)

# of Collaborated Projects: 11 results

# of Collaborated Products: 29 results
2. Furuse Motomasa (70340560)

# of Collaborated Projects: 10 results

# of Collaborated Products: 25 results
3. IKEDA Naokado (50434775)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
4. Wanibuchi Masahiko (30343388)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
5. MIYATAKE Shinichi (90209916)

# of Collaborated Projects: 5 results

# of Collaborated Products: 19 results
6. Hiramatsu Ryo (40609707)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
7. Yagi Ryokichi (00632283)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 中村浩之 (30274434)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 高見俊宏 (20305626)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. YAMADA Yoshitaka (00368101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUROIWA Toshihiko (30178115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. KAJIMOTO Yoshinaga (30224413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. DEZAWA Mari (50272323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. 藤田貢 (40609997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 近藤夏子 (00582131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. 奥崎大介 (00346131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 佐々木祐典 (20538136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐々木優子 (80631142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 本望修 (90285007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 亀田雅博 (50586427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MICHIUE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 小野公二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 寺崎瑞彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 斯波宏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nonoguchi Naosuke 野々口 直助

NONOGUCHI Naosuke 野々口 直助

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悪性神経膠腫・悪性髄膜種において新規分子標的となる転写キメラの同定とその機能解析Principal Investigator

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Search for biomarkers of sensitivity to MTX monotherapy in primary central nervous system lymphomaPrincipal Investigator

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Nonoguchi Naosuke 野々口直助

NONOGUCHI Naosuke 野々口直助

[Book] 脳神経外科臨床マニュアル　（42章中枢神経系原発悪性リンパ腫の診断と治療）2019