Moriya-Ito Keiko 守屋敬子

… Alternative Names

MORIYA-ITO Keiko 守屋敬子

MORIYA Keiko 守屋敬子

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Researcher Number	70392371
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員 2025: 公益財団法人東京都医学総合研究所, 先端基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 公益財団法人東京都医学総合研究所, 脳・神経科学研究分野, 研究員 2013 – 2014: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 2010: 東京都医学研究機構, 研究員 2010: 財団法人東京都医学研究機構, 東京都神経科学総合研究所, 研究員 2008: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員 2008: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員 2007: Tokyo Metropolitan Organization for Medical Research, 東京都神経科学総合研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 44020:Developmental biology-related / Basic Section 45020:Evolutionary biology-related / Morphology/Structure Except Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Integrative animal science / Morphology/Structure / Basic veterinary science/Basic zootechnical science / Nerve anatomy/Neuropathology
Keywords	Principal Investigator 霊長類 / コモンマーモセット / 副嗅球 / 鋤鼻系 / 空間トランスクリプトーム解析 / 脳発生 / サブプレート / 霊長目 / 鋤鼻感覚 / 進化 … More / 内側扁桃体 / マーモセット / 神経トレーサー / 扁桃体内側核 / 扁桃体皮質核 / 鋤鼻器 / 神経科学 / 共焦点レーザー顕微鏡 / 樹状突起スパイン / 相反シナプス / 三次元構築 / 電子顕微鏡 / フェロモン記憶 … More Except Principal Investigator 副嗅球 / フェロモン / マウス / シナプス可塑性 / 記憶 / 嗅内野 / 記憶回路 / 海馬 / トレーサー手法 / 神経線維連絡 / マーモセット / Endopiriform nucleus / 前障 / 前海馬台 / オキシトシン / 社会記憶 / ブルース効果 / 可塑性 / 電子顕微鏡 / 鋤鼻系 / ニューロン / 主嗅球 / rostral migratory stream / 細胞移動 / rostral miratory Stream / 糸球体周辺細胞 / 生後神経新生 / 脳室周囲層 / 傍糸球体細胞 / 糸球体 / 共培養 / GFP / カルシウム / ノルアドレナリン / リアルタイムイメージング / 共焦点レーザー顕微鏡 / ノルアドレリン / 鋤鼻器 / 副嗅球ニューロン / 棘突起 / 神経可塑性 / 神経再生 Less

Primate-specific subplate functions and mechanisms leading to expansion of the cerebral cortexPrincipal Investigator
- Principal Investigator
  
  守屋敬子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
動物種を超えた記憶の基盤構造解明と霊長目マーモセットにおける付加的線維連絡の探索
- Principal Investigator
  
  本多祥子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Tokyo Women's Medical University
Would experimental attempts at evolutionary sensory deprivation lead to changes in neural circuits?Principal Investigator
- Principal Investigator
  
  MORIYA-ITO Keiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45020:Evolutionary biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Identification of cells involved in pheromonal memory governing pregnancy maintenance.
- Principal Investigator
  
  MOGI KAZUTAKA
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Integrative animal science
- Research Institution
  Azabu University
Morphological analysis of synapse underlying pheromonal memory
- Principal Investigator
  
  ICHIKAWA Masumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Real-time imaging of synapse underlying pheromonal memory
- Principal Investigator
  
  ICHIKAWA Masumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
The morphological analysis of the neural circuit about initial analysis zone of the pheromone information.
- Principal Investigator
  
  YOKOSUKA Makoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Nippon Veterinary and Life Science University
3D-microstructural analysis of accessory olfactory neurons encoding phoeromonal memoryPrincipal Investigator
- Principal Investigator
  
  MORIYA Keiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphology/Structure
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

All 2024 2023 2022 2013 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Hippocampal Connectivity of the Presubiculum in the Common Marmoset (Callithrix jacchus)2022
- Author(s)
  Honda Yoshiko、Shimokawa Tetsuya、Matsuda Seiji、Kobayashi Yasushi、Moriya-Ito Keiko
- Journal Title
  
  Frontiers in Neural Circuits
  
  Volume: 16
- DOI
  10.3389/fncir.2022.863478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06463
[Journal Article] Three-dimensional reconstruction of electron micrographs reveals intrabulbar circuit differences between accessory and main olfactory bulbs2013
- Author(s)
  Moriya-Ito　K, Endoh　K, Fujiwara-Tsukamoto　Y, Ichikawa　M
- Journal Title
  
  Frontier in Neuroanatomy
  
  Volume: ７ Pages: 1-8
- DOI
  10.3389/fnana.2013.00005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570084, KAKENHI-PROJECT-25430013
[Journal Article] Three-dimensional reconstruction of electron micrographs reveals intrabulbar circuit differences between accessory and main olfactory bulb2013
- Author(s)
  Moriya-Ito K, Endoh K, Fujiwara-Tsukamoto Y, Ichikawa M
- Journal Title
  
  Frontiers in Neuroanatomy
  
  Volume: 7(On line journal)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570084
[Journal Article] Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb.2011
- Author(s)
  Wu Y, Moriya-Ito K, Iwakura T, Tsutiya A, Ichikawa M, Ohtani-Kaneko R
- Journal Title
  
  Neuroscience Letters
  
  Volume: 500 Pages: 77-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570084
[Journal Article] Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb2011
- Author(s)
  Wu Y, Moriya-Ito K, Iwakura T, Tsuchiya A, Ichikawa M, Ohtani-Kaneko R
- Journal Title
  
  Neurosci Letter
  
  Volume: 500 Pages: 77-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570084
[Journal Article] Vomeronasal neurons promote synaptic formation on dendritic spines but not dendritic shafts in primary culture of accessory olfactory bulb neurons2009
- Author(s)
  Moriya-Ito K, Endoh K, Ichikawa M
- Journal Title
  
  Neurosci Lett 451
  
  Pages: 20-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770053
[Journal Article] 副嗅球・僧帽/房飾細胞の樹状突起におけるシナプスの三次元的配置2009
- Author(s)
  遠藤堅太郎, 守屋敬子、塚本葉子, 市川眞澄
- Journal Title
  
  日本味と匂学会誌 16
  
  Pages: 541-544
- NAID
  110007568804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20500319
[Journal Article] Vomeronasal neurons promote synaptic formation on dendritic spines but not dendritic shafts in primary culture of accessory olfactory bulb neurons.2009
- Author(s)
  Moriya-Ito K, Endoh K, Ichikawa M
- Journal Title
  
  Neurosci Lett. 451
  
  Pages: 20-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770053
[Journal Article] Vomeronasal neurons promote synaptic formation on dendritic spines but not dendritic shafts in primary culture of accessory olfactory bulb neurons.2009
- Author(s)
  Moriya-Ito K, Endo K, Ichikawa M
- Journal Title
  
  Neurosci letters 451
  
  Pages: 20-24
- Data Source
  KAKENHI-PROJECT-20500319
[Journal Article] (2009) Vomeronasal neurons promote synaptic formation on dendritic spines but not dendritic shafts in primary culture of accessory olfactory bulb neurons2009
- Author(s)
  Moriya-Ito K, Endo K, Ichikawa M
- Journal Title
  
  Neuroscience Letter 451
  
  Pages: 20-24
- Data Source
  KAKENHI-PROJECT-20500319
[Journal Article] 培養系を用いた鋤鼻器・副嗅球の形態解析2008
- Author(s)
  守屋敬子、市川眞澄
- Journal Title
  
  AROMA RESEARCH 9
  
  Pages: 6-9
- Data Source
  KAKENHI-PROJECT-19770053
[Journal Article] 陪養系を用いた鋤鼻器・副嗅球の形態解析2008
- Author(s)
  守屋敬子, 市川眞澄
- Journal Title
  
  Aroma Research 9
  
  Pages: 6-9
- Data Source
  KAKENHI-PROJECT-20500319
[Journal Article] 培養系を用いた鋤鼻器・副嗅球の形態解析2008
- Author(s)
  守屋敬子、市川眞澄
- Journal Title
  
  Aroma Research 9
  
  Pages: 6-9
- Data Source
  KAKENHI-PROJECT-20500319
[Journal Article] 培養系を用いた鋤鼻器・副嗅球の形態解析2008
- Author(s)
  守屋敬子、市川眞澄
- Journal Title
  
  AROMA RESEARCH 9
  
  Pages: 6-9
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] コモンマーモセット大脳皮質発生におけるサブプレート層の系統学的特性2024
- Author(s)
  守屋敬子
- Organizer
  第13回日本マーモセット研究会大会
- Data Source
  KAKENHI-PROJECT-21K06298
[Presentation] マーモセットにおける前海馬台ー前脳領域間結合関係2023
- Author(s)
  本多祥子, 守屋敬子, 下川哲哉, 小林靖
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] マーモセット前海馬台の神経線維連絡2023
- Author(s)
  本多祥子, 守屋敬子, 下川哲哉, 小林靖
- Organizer
  第12回日本マーモセット研究会大会
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] Afferent projections of the presubiculum from frontal brain regions and claustrum-endopiriform complex in the common marmoset.2023
- Author(s)
  HONDA Yoshiko, MORIYA-ITO Keiko, SHIMOKAWA Tetsuya, KOBAYASHI Yasushi
- Organizer
  The 46th Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] マーモセット前海馬台の神経線維連絡2023
- Author(s)
  本多祥子, 守屋敬子, 下川哲哉, 小林靖
- Organizer
  第12回日本マーモセット研究会大会
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] マーモセットにおける前海馬台ー前脳領域間結合関係2023
- Author(s)
  本多祥子, 守屋敬子, 下川哲哉, 小林靖
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] Direct hippocampo-presubicular projections in the common marmoset.2022
- Author(s)
  HONDA Yoshiko, SHIMOKAWA Tetsuya, MATSUDA Seiji, KOBAYASHI Yasushi, MORIYA-ITO Keiko
- Organizer
  NEURO 2022
- Data Source
  KAKENHI-PROJECT-22K06463
[Presentation] マーモセット鋤鼻器の形態学的解析2013
- Author(s)
  守屋敬子, 山岸公子, 田中いく子, 市川眞澄, 徳野博信
- Organizer
  第3回日本マーモセット研究会大会
- Place of Presentation
  福岡市
- Year and Date
  2013-12-12
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 鋤鼻器の形態学的解析より推察するコモンマーモセットの鋤鼻感覚能2013
- Author(s)
  守屋敬子、山岸公子、若林嘉浩、田中いく子、市川眞澄、徳野博信
- Organizer
  日本味と匂学会　第４７回大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 鋤鼻器の形態学的解析より推察するコモンマーモセットの鋤鼻感覚能2013
- Author(s)
  守屋敬子, 山岸公子, 若林嘉浩, 田中いく子, 市川眞澄, 徳野博信
- Organizer
  日本味と匂学会第47回大会
- Place of Presentation
  仙台市
- Year and Date
  2013-09-04
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 副嗅球顆粒細胞の超微細形態とシナプス可塑性2011
- Author(s)
  守屋敬子, 遠藤堅太郎, 塚元葉子, 市川眞澄
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜市
- Year and Date
  2011-09-17
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 齧歯類における副嗅球内微細構造と樹状突起スイン可塑的変化2011
- Author(s)
  守屋敬子、遠藤堅太郎、市川眞澄
- Organizer
  日本動物学会第82回大会(招待講演)
- Place of Presentation
  旭川
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 齧歯類における副嗅球内微細形態と樹状突起スパイン可塑的変化2011
- Author(s)
  守屋敬子, 遠藤堅太郎, 市川眞澄
- Organizer
  日本動物学会第82回大会、シンポジウム"視覚と嗅覚における似て非なる神経機構のリサーチフロント"
- Place of Presentation
  旭川
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23570084
[Presentation] 副嗅球におけるノルアドレナリン神経修飾とシナプス可塑的変化2010
- Author(s)
  守屋敬子、市川眞澄
- Organizer
  日本味と匂学会第44回大会
- Place of Presentation
  小倉市
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] 副嗅球におけるノルアドレナリン神経修飾とシナプス可塑的変化2010
- Author(s)
  守屋敬子、市川眞澄
- Organizer
  日本味と匂学会第44回大会
- Place of Presentation
  北九州国際会議場(福岡県)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] ノルアドレナリンにより調節される副嗅球ニューロン内カルシウム変動の解析2009
- Author(s)
  守屋敬子、市川眞澄
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋市
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] ラット副嗅球におけるシナプス結合様式の三次元的電子顕微鏡解析2009
- Author(s)
  遠藤堅太郎、守屋敬子、塚本葉子、市川眞澄
- Organizer
  日本動物学会第80回大会
- Place of Presentation
  静岡市
- Year and Date
  2009-09-17
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] 副嗅球・僧帽/房飾細胞の樹状突起におけるシナプスの三次元的配置2009
- Author(s)
  遠藤堅太郎、守屋敬子、塚本葉子、市川眞澄
- Organizer
  日本味と匂学会第43回大会
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] フェロモン記憶形成に関わるオキシトシン作用の解明2009
- Author(s)
  森泰隆、守屋敬子、町田武生、市川眞澄
- Organizer
  第61回日本動物学会関東支部大会
- Place of Presentation
  埼玉大学
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] ノルアドレナリンにより調節される副嗅球ニューロンカルシウム変動の解析2009
- Author(s)
  守屋敬子、市川眞澄
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] フェロモン記憶形成に関わるオキシトシン作用の解明2009
- Author(s)
  森泰隆、守屋敬子、町田武生、市川眞澄
- Organizer
  第61回日本動物学会関東支部大会
- Place of Presentation
  埼玉大学
- Year and Date
  2009-03-20
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] ラット副嗅球介在ニューロンの形態的特徴と樹状突起ダイナミズム2008
- Author(s)
  守屋敬子、市川眞澄,
- Organizer
  日本動物学会第79回大会
- Place of Presentation
  福岡大学
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] 培養副嗅球を用いたノルアドレナリン作用の解析2008
- Author(s)
  星田千晴、守屋敬子、市川眞澄
- Organizer
  第60回動物学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2008-03-22
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] Dendritic morphology and spine motility of interneurons in accessory olfactory bulb2008
- Author(s)
  Moriya-Ito, K. , Ichikawa, M
- Organizer
  Neuro2008
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] Dendritic morphology and spine motility of interneurons in accessory olfactory bulb.2008
- Author(s)
  守屋敬子, 市川眞澄
- Organizer
  Neuro2008
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20500319
[Presentation] ラット副嗅球介在ニューロンの形態的特徴と樹状突起ダイナミズム2008
- Author(s)
  守屋敬子、市川眞澄
- Organizer
  日本動物学会第79回大会
- Place of Presentation
  福岡大学
- Year and Date
  2008-09-05
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] 副嗅球ニューロンにおけるノルアドレナリン作用解析の解析2007
- Author(s)
  星田千晴、守屋敬子、市川眞澄
- Organizer
  日本味と匂学会第41回大会
- Place of Presentation
  江戸川区船堀
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] 副嗅球共培養条件下における副嗅球ニューロンのシナプス形態解析2007
- Author(s)
  守屋敬子、遠藤堅太郎、市川眞澄, 鋤鼻ー
- Organizer
  日本味と匂学会第41回大会
- Place of Presentation
  江戸川区船堀
- Year and Date
  2007-07-27
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] Synaptic characterization and dendritic spine motility of accessoy olfactory bulb neurons in coculture with vomeronasal neurons2007
- Author(s)
  Keiko Moriya-lto, Kentaroh Endoh and Masumi Ichikawa
- Organizer
  Neuroscience 2007
- Place of Presentation
  San Diego Convention Center(San Diego,USA)
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] Synaptic characterization and dendritic spine motility of accessory olfactory bulb neurons in coculture with vomeronasal neurons2007
- Author(s)
  Moriya-Ito,K. ,Endo,K. ,Ichikawa,M
- Organizer
  2007 Neuroscience Meeting
- Place of Presentation
  San Diego
- Year and Date
  2007-11-04
- Data Source
  KAKENHI-PROJECT-19770053
[Presentation] 鋤鼻-副嗅球共培養条件下における副嗅球ニューロンのシナプス形態解析2007
- Author(s)
  守屋敬子、遠藤堅太郎、市川眞澄
- Organizer
  日本味と匂学会第41回大会
- Place of Presentation
  タワーホール船堀(東京
- Year and Date
  2007-07-27
- Data Source
  KAKENHI-PROJECT-19770053

1. ICHIKAWA Masumi (20124414)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. YOKOSUKA Makoto (90280776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MOGI KAZUTAKA (50347308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 本多祥子 (40287313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 市川真澄

# of Collaborated Projects: 0 results

# of Collaborated Products: 24 results
6. 本田祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

Moriya-Ito Keiko 守屋 敬子

MORIYA-ITO Keiko 守屋 敬子

MORIYA Keiko 守屋 敬子

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Primate-specific subplate functions and mechanisms leading to expansion of the cerebral cortexPrincipal Investigator

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動物種を超えた記憶の基盤構造解明と霊長目マーモセットにおける付加的線維連絡の探索

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Would experimental attempts at evolutionary sensory deprivation lead to changes in neural circuits?Principal Investigator

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Identification of cells involved in pheromonal memory governing pregnancy maintenance.

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Morphological analysis of synapse underlying pheromonal memory

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Real-time imaging of synapse underlying pheromonal memory

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The morphological analysis of the neural circuit about initial analysis zone of the pheromone information.

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3D-microstructural analysis of accessory olfactory neurons encoding phoeromonal memoryPrincipal Investigator

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[Journal Article] Hippocampal Connectivity of the Presubiculum in the Common Marmoset (Callithrix jacchus)2022

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[Journal Article] Three-dimensional reconstruction of electron micrographs reveals intrabulbar circuit differences between accessory and main olfactory bulbs2013

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[Journal Article] Three-dimensional reconstruction of electron micrographs reveals intrabulbar circuit differences between accessory and main olfactory bulb2013

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[Journal Article] Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb.2011

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[Journal Article] Sexually dimorphic effects of estrogen on spines in cultures of accessory olfactory bulb2011

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[Journal Article] Vomeronasal neurons promote synaptic formation on dendritic spines but not dendritic shafts in primary culture of accessory olfactory bulb neurons2009

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Moriya-Ito Keiko 守屋敬子

MORIYA-ITO Keiko 守屋敬子

MORIYA Keiko 守屋敬子