Yuan Xunmei 袁勲梅

Researcher Number	70392404
Other IDs
Affiliation (Current)	2025: 名古屋大学, 環境医学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2019: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座助教 2016 – 2017: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 2014 – 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Applied health science
Keywords	Principal Investigator エピジェネティクス / DNAメチル化 / DOHaD / FGF21 / PPARα / FGF2 / FGF21遺伝子特異的DNA脱メチル化 / PGC1α / 先制医療 / DOHaD仮説 … More / エピゲノム制御 / エピゲノム記憶 / DNA脱メチル化 / エピジェネティックメモリー Less

Molecular mechanism and functional meaning of PPARalpha-dependent DNA demethylation of FGF21 genePrincipal Investigator
- Principal Investigator
  
  Yuan Xunmei
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Medical and Dental University
Analysis of epigenetic memory of FGF21 gene in the liverPrincipal Investigator
- Principal Investigator
  
  Yuan Xunmei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.2020
- Author(s)
  Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 5181-5181
- DOI
  10.1038/s41598-020-62035-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K18000, KAKENHI-PROJECT-17H03613, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-17K01840, KAKENHI-PROJECT-19K09018, KAKENHI-PROJECT-20H03381
[Journal Article] Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis2019
- Author(s)
  Asakawa M, Itoh M, Suganami T, Sakai T, Kanai S, Shirakawa I, Yuan X, Hatayama T, Shimada S, Akiyama Y, Fujiu K, Inagaki Y, Manabe I, Yamaoka S, Yamada T, Tanaka S, Ogawa Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 19601-19601
- DOI
  10.1038/s41598-019-56039-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07143, KAKENHI-PROJECT-19K07475, KAKENHI-PROJECT-19K22627, KAKENHI-PUBLICLY-18H05039, KAKENHI-PROJECT-19H01054, KAKENHI-PROJECT-19H01055, KAKENHI-PROJECT-17H04166, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-17K01840, KAKENHI-PROJECT-18K19575
[Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood2018
- Author(s)
  X Yuan, K Tsujimoto, K Hashimoto, K Kawahori, N Hanzawa, M Hamaguchi, T Seki, M Nawa, T Ehara, Y Kitamura, I Hatada, M Konishi, N Itoh, Y Nakagawa, H Shimano, T Takai-Igarashi, Y Kamei, Y Ogawa.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 636-636
- DOI
  10.1038/s41467-018-03038-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00295, KAKENHI-PROJECT-16K01811, KAKENHI-PROJECT-17K01840, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-16H03253, KAKENHI-PROJECT-16H05331, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-18K18461, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-16H04926, KAKENHI-PROJECT-17H06652
[Journal Article] Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring2018
- Author(s)
  Kawahori K, Hashimoto K, Yuan X, Tsujimoto K, Hanzawa N, Hamaguchi M, Kase S, Fujita K, Tagawa K, Okazawa H, Nakajima Y, Shibusawa N, Yamada M, Ogawa Y
- Journal Title
  
  Thyroid
  
  Volume: 28 Issue: 3 Pages: 395-406
- DOI
  10.1089/thy.2017.0331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K01840, KAKENHI-PUBLICLY-16H01354, KAKENHI-PROJECT-16H02655, KAKENHI-PROJECT-16H05331, KAKENHI-PROJECT-17H06652
[Journal Article] エネルギー代謝とDNAメチル化制御2016
- Author(s)
  辻本和峰, 橋本貢士, 袁勲梅, 川堀健一, 榛澤望, 小川佳宏
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 2493-2499
- Data Source
  KAKENHI-PROJECT-26350884
[Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.2014
- Author(s)
  Ehara T, Kamei Y, Yuan X, Takahashi M, Kanai S, Tamura E, Tsujimoto K, Tamiya T, Nakagawa Y, Shimano H, Takai-Igarashi T, Hatada I, Suganami T, Hashimoto K, Ogawa Y.
- Journal Title
  
  Diabetes.
  
  Volume: 64(3) Issue: 3 Pages: 775-84
- DOI
  10.2337/db14-0158
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390230, KAKENHI-PUBLICLY-25126701, KAKENHI-PUBLICLY-25126723, KAKENHI-PROJECT-26670448, KAKENHI-PROJECT-26350884, KAKENHI-PROJECT-15K12669, KAKENHI-PROJECT-25292076
[Presentation] PGC1α欠損マウスを用いてDNA脱メチル化の網羅的解析2019
- Author(s)
  袁勲梅
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K01840
[Presentation] Molecular Mechanism and Physiological Meaning of Epigenetic Regulation of FGF21 Gene Expression2019
- Author(s)
  袁勲梅
- Organizer
  7th International Conference on Food Factors
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01840
[Presentation] マウス乳仔期肝臓でのDNA脱メチル化における転写共役因子PGC1αの役割2018
- Author(s)
  袁勲梅
- Organizer
  第41回日本分子生物年会
- Data Source
  KAKENHI-PROJECT-17K01840
[Presentation] FGF21遺伝子発現のエピゲノム制御：その分子機構と機能の意義2017
- Author(s)
  袁勲梅
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K01840
[Presentation] 母獣が摂取する飽和脂肪酸およびn-3系脂肪酸油脂が及ぼす仔の肝臓における遺伝子発現への影響2016
- Author(s)
  高橋真由美、袁勲梅、橋本貢士、小川佳宏
- Organizer
  第70回日本栄養・食糧学会大会
- Place of Presentation
  神戸ポートピアホテル（神戸）
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] Fibroblast growth factor 21遺伝子発現のエピゲノム制御と機能的意義2016
- Author(s)
  辻本和峰, 橋本貢士, 袁勲梅, 川堀健一, 榛澤望, 小川佳宏
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル（東京）
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] Fibroblast growth factor 21遺伝子のDNAメチル化制御機構とその生理的意義2016
- Author(s)
  橋本貢士, 袁勲梅, 辻本和峰, 川堀健一, 榛澤望, 小川佳宏
- Organizer
  第34回内分泌代謝サマーセミナー
- Place of Presentation
  久山温泉　ホテル夢家（福岡）
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 胎仔期から乳仔期における母体栄養環境に応じた代謝関連遺伝子発現のDNAメチル化制御2016
- Author(s)
  袁勲梅, 橋本貢士, 辻本和峰, 川堀健一, 榛澤望, 中林一彦, 秦健一郎, 伊東宏晃, 小川佳宏
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル（東京）
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 胎仔期から乳仔期におけるFibroblast Growth Factor 21(FGF21)遺伝子発現のエピゲノム制御機構2015
- Author(s)
  辻本和峰, 橋本貢士, 袁勲梅, 川堀健一, 小川佳宏
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京(東京都、千代田区）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] マウス肝臓におけるFGF21遺伝子発現のエピゲノム制御とその分子機構の解明2015
- Author(s)
  袁勲梅, 辻本和峰, 川堀健一, 橋本貢士, 小川佳宏
- Organizer
  BMB2015:第38回日本分子生物学会年会・第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 胎生期から乳仔期におけるマウスFibroblast Growth Factor 21(FGF21)遺伝子発現のエピゲノム制御2015
- Author(s)
  辻本和峰, 橋本貢士, 袁勲梅, 川堀健一, 小川佳宏
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 胎仔期から乳仔期におけるマウスFibroblast Growth Factor 21(FGF21)遺伝子発現のエピゲノム制御2015
- Author(s)
  橋本貢士, 袁勲梅, 辻本和峰, 川堀健一, 小川佳宏
- Organizer
  第4回日本DOHaD研究会学術集会
- Place of Presentation
  昭和大学（東京都、品川区）
- Year and Date
  2015-08-01
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] Peroxisome Proliferator-activated Receptor(PPAR)αを介するFibroblast Growth Factor 21(FGF21)遺伝子発現のエピゲノム制御2015
- Author(s)
  辻本和峰, 橋本貢士, 袁勲梅, 川堀健一, 小川佳宏
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  グランプラス　セント・ヴァレンタイン（山口県、下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 胎生期から乳仔期におけるFibroblast Growth Factor (FGF) 21 遺伝子発現のエピゲノム制御2014
- Author(s)
  辻本和峰、袁勲梅、川堀健一、橋本貢士、小川佳宏
- Organizer
  第19回アディポサイエンス・シンポジウム
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2014-08-23
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] 核内受容体PPARαを介するFibroblast Growth Factor (FGF) 21 遺伝子発現のDNAメチル化制御2014
- Author(s)
  辻本和峰、橋本貢士、川堀健一、袁勲梅、小川佳宏
- Organizer
  第35回日本肥満学会
- Place of Presentation
  シーガイアコンベンションセンター
- Year and Date
  2014-10-25
- Data Source
  KAKENHI-PROJECT-26350884
[Presentation] Epigenetic regulation of hepatic lipid metabolism through neonatal milk intake2014
- Author(s)
  Xunmei Yuan, Yasutomi Kamei, Yoshihiro Ogawa
- Organizer
  第 4 回食と生命のサイエンス・フォーラム
- Place of Presentation
  東京大学伊藤謝恩ホール
- Year and Date
  2014-11-15
- Data Source
  KAKENHI-PROJECT-26350884

1. HASHIMOTO Koshi (30396642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. OGAWA Yoshihiro (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
3. TSUJIMOTO Kazutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. KAWAHORI Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
5. HANZAWA Nozomi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 五十嵐貴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 中川嘉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 島野仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森田純代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 山岡昇司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yuan Xunmei 袁 勲梅

Research Projects

Research Products

Co-Researchers

Molecular mechanism and functional meaning of PPARalpha-dependent DNA demethylation of FGF21 genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of epigenetic memory of FGF21 gene in the liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Upregulation of cancer-associated gene expression in activated fibroblasts in a mouse model of non-alcoholic steatohepatitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] エネルギー代謝とDNAメチル化制御2016

Author(s)

Journal Title

Data Source

[Journal Article] Ligand-activated PPARα-dependent DNA demethylation regulates the fatty acid β-oxidation genes in the postnatal liver.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] PGC1α欠損マウスを用いてDNA脱メチル化の網羅的解析2019

Author(s)

Organizer

Data Source

[Presentation] Molecular Mechanism and Physiological Meaning of Epigenetic Regulation of FGF21 Gene Expression2019

Author(s)

Organizer

Data Source

[Presentation] マウス乳仔期肝臓でのDNA脱メチル化における転写共役因子PGC1αの役割2018

Author(s)

Organizer

Data Source

[Presentation] FGF21遺伝子発現のエピゲノム制御：その分子機構と機能の意義2017

Author(s)

Organizer

Data Source

[Presentation] 母獣が摂取する飽和脂肪酸およびn-3系脂肪酸油脂が及ぼす仔の肝臓における遺伝子発現への影響2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Fibroblast growth factor 21遺伝子発現のエピゲノム制御と機能的意義2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Fibroblast growth factor 21遺伝子のDNAメチル化制御機構とその生理的意義2016

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 胎仔期から乳仔期における母体栄養環境に応じた代謝関連遺伝子発現のDNAメチル化制御2016

Author(s)

Organizer

Place of Presentation

Yuan Xunmei 袁勲梅