WATANABE HIROSHI 渡邊博志

… Alternative Names

WATANABE Hiroshi 渡邊博志

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Researcher Number	70398220
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(薬), 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 熊本大学, 大学院生命科学研究部(薬), 教授 2019 – 2022: 熊本大学, 大学院生命科学研究部(薬), 准教授 2011 – 2019: 熊本大学, 薬学部, 准教授 2008 – 2010: 熊本大学, 薬学部, 講師 2007: 熊本大, 薬学部, 講師 … More 2006: Kumamoto University, School of Pharmacy, Associate frotessor, 薬学部, 講師 2005: 熊本大学, 医学部付属病院, 助手 2005: 熊本大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 47060:Clinical pharmacy-related / Applied pharmacology Except Principal Investigator Applied pharmacology / Medical pharmacy / Basic Section 90120:Biomaterials-related / Basic Section 53040:Nephrology-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 慢性腎臓病 / アルブミン / 酸化ストレス / 尿毒症物質 / 糸球体バリア / AGP / バイオマーカー / 酸化アルブミン / 腎病態 / 筋萎縮 … More / 脂肪酸 / 腎疾患 / 尿毒素 / 腎炎症 / orosomucoid / 敗血症 / AKI to CKD / 炎症 / 蛋白尿 / オロソムコイド / 診断 / 腎臓病 / 翻訳後修飾 / AOPP / CKD / 脂肪炎症 / AOPPs / 酸化損傷蛋白質 / 酸化還元 / 慢性性腎臓病 / サルコペニア / 糖尿病性腎臓病 / α1-酸性糖タンパク質 / マクロファージ / アドリアマイシン腎障害 / α1-酸性糖蛋白質 / ビタミンD / 腎線維化 / macrophage / TLR4 / kidney disease / alfa1-acid glycoprotein / 腎-多臓器連関 / 骨格筋 / 腎ー多臓器連関 / 薬学 / ABCG2 / 副甲状腺ホルモン / 二次性副甲状腺機能亢進症 / バイカーカー / Elovl6 / 脂肪酸代謝 / CYP3A / 尿酸 / NADPH oxidase / 血管障害 / アルブミン尿 / 個別化医療 / 心血管障害 / 腎障害 / インドキシル硫酸 / PTH / 薬物動態制御タンパク質 / 個別化投与設計 / スタチン / 腎不全 / 体内動態 / 代謝酵素 / トランスポータ / コレステロール / 慢性骨髄性白血病 / 分子マーカー / P-糖蛋白質 / イマチニブ … More Except Principal Investigator アルブミン / ドラッグデリバリーシステム / ドラッグデリバリー / アルブミン融合技術 / バイオミメティック / ドラックデリバリー / DDS / 肺障害 / Pichia酵母 / ヒト血清アルブミン / 腎障害 / 急性腎障害 / 細胞膜透過性ペプチド / アジュバント / ドラックデリバリーシステム / ワクチン / 癌 / 感染症 / 免疫療法 / 膜透過ペプチド / β2-ミクログロブリン / 慢性腎臓病 / アミロイドーシス / 脂肪酸修飾環状抗体 / 血中滞留性 / 脂肪酸 / 環状一本鎖抗体 / 低分子抗体 / バイオミメティクDDS / sActRIIB / グレリン / チオレドキシン / 筋萎縮因子 / ミオスタチン / 健康寿命 / サルコペニア / ヘムオキシゲナーセ-1 / 災害医療 / アルブミン創薬プラットフォーム / 横紋筋融解症 / COデリバリーシステム / 細胞療法 / 赤血球 / 一酸化炭素 / P-glycoprotein / pharmacokinetics / therapeutic drug monitoring / amurubicinol / amurubic in / ファーマコダイナミクス / 個別化 / 薬剤耐性 / 細胞膜輸送 / P-糖蛋白質 / ファーマコキネティクス / 血中濃度モニタリング / アムルビシノール / アムルビシン / 腫瘍治療効果 / 抗がん剤 / 薬力学的評価 / 体内動態解析 / デリバリーシステム / 骨髄指向性 / リポソーム / チオレドキン / 肝障害 / 病態モデル / 多臓器不全治療 / レドックス / ナノメディスン / 毒性中和 / ハイブリッド / 毒素中和 / 分子進化工学 / 血液浄化法 / 癌治療 / 一酸化窒素 / 免疫沈降法 / ドメイン / ファージ / 変異体 / Aβ / Thioredexin 1 / 酸化ストレス / 抗酸化能 / Thioredoxin 1 / 分子標的薬 / α_<1->酸性糖タンパク質 / 肝取り込み / X線結晶構造解析 / リガンド結合 / バリアント / α_1-酸性糖タンパク質 / タンパク結合 / 体内動態 / 多型情報 / α1-酸性糖タンパク質 / 血清タンパク質 / シスプラチン / インドキシル硫酸 / 尿毒症物質 / 薬物排泄 / 腎尿細管 / 抗癌薬 / 薬物トランスポータ / 薬剤性腎障害 Less

Evaluation of fatty acid structures that improve the retention of antibody fragments in blood.
- Principal Investigator
  
  森岡弘志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kumamoto University
ウレミックトキシンによるアルブミン機能異常の解析と恒常性を回復する治療法の開発
- Principal Investigator
  
  山本卓
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
膜透過能とアジュバント活性を併せ持つ機能性アルブミンの創製と免疫療法への応用
- Principal Investigator
  
  丸山徹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kumamoto University
Elucidation of the molecular basis of proteinuria suppression by the acute phase protein orosomucoid and its application to the treatment of chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kumamoto University
Development of Biomimetic DDS to improve healthy longevity and its application to the treatment for sarcopenia
- Principal Investigator
  
  Maruyama Toru
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kumamoto University
Elucidation of CKD pathophysiology and development of diagnostic and therapeutic strategies based on comprehensive post-translational modification analysis of albuminPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kumamoto University
Development of a renal carbon monoxide delivery system for treatment of lethal rhabdomyolysis
- Principal Investigator
  
  Maruyama Toru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kumamoto University
Treatment strategy based on the pathophysiology of renal-multi-organ axis induced by pathogenic albuminPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Treatment strategy for kidney disease based on TLR4-macrophage control by alfa1-acid glycoproteinPrincipal Investigator
- Principal Investigator
  
  Watanabe Hiroshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Development of a novel carrier for tumor associated macrophage and its application to cancer immunotherapy
- Principal Investigator
  
  MARUYAMA TORU
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Development of renal delivery system for hybridized tissue regenerating factors and its application for kidney disease
- Principal Investigator
  
  MARUYAMA TORU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Strategy for the personalized CKD medicine based on the crosstalk between albumin-bound uremic toxin and kidneyPrincipal Investigator
- Principal Investigator
  
  Hiroshi Watanabe
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Construction of an Innovative Bone Marrow Delivery System of Anticancer Drug for Control of Malignant Tumors' Bone Metastasis
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Sojo University
Design and Evaluation of Next Generation Albumin-thioredoxin Fusion Protein for Multiple Organ Failure Treatment
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Sojo University
The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment
- Principal Investigator
  
  MARUYAMA Toru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Development of effective blood purification treatment method usingHSA bound toxic comnpodus designed bpyhase display tecnohlogy
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Sojo University
Development of individualized drug therapy based on the regulation of drug metabolism and transport proteins by uremic toxinsPrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Development of Redox Controlling Nanomedicine Based on Albumin Fusion
- Principal Investigator
  
  OTAGIRI Masaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Sojo University
Aβペプチド捕獲型アルブミン製剤の開発とアルツハイマー病治療への応用
- Principal Investigator
  
  小田切優樹
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Sojo University
Analysis of intestinal cholesterol absorption for the personalized medicine against hypercholesterolemiaPrincipal Investigator
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Strategy for the personalized medicine of molecular target drug based on the polymorphism information of plasma protein
- Principal Investigator
  
  MARUYAMA Toru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
イマチニブ血中濃度モニタリングと薬物動態関連遺伝子解析に基づく個別治療戦略の開発Principal Investigator
- Principal Investigator
  
  渡邊博志
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University
Strategy for protection of kidney injury based on functioal relation betwee renal specific stress response mechanisms and xenobiotic detoxication systems
- Principal Investigator
  
  SAITO Hideyuki
- Project Period (FY)
  2005 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kumamoto University
Development of dosage individualization of anti-tumor drugs based on therapeutic drug monitoring and pharmacokinetic-related gene expression
- Principal Investigator
  
  MATSUMOTO Mitsuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kumamoto University

[Book] Molecular mechanism of muscle wasting in CKD. Recent advances of sarcopenia and frailty in CKD2020
- Author(s)
  Watanabe H, Enoki Y, Maruyama T
- Publisher
  Springer
- ISBN
  9789811523656
- Data Source
  KAKENHI-PROJECT-18H02604
[Book] アンメットな腎疾患の病態制御を指向した診断・治療戦略への挑戦2020
- Author(s)
  渡邊博志、丸山徹
- Total Pages
  3
- Publisher
  ファルマシア12月号日本薬学会
- Data Source
  KAKENHI-PROJECT-20H03406
[Book] Molecular mechanism of muscle wasting in CKD. Recent advances of sarcopenia and frailty in CKD2020
- Author(s)
  Watanabe H, Enoki Y, Maruyama T
- Total Pages
  20
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] Molecular mechanism of muscle wasting in CKD. Recent advances of sarcopenia and frailty in CKD, edited by Kato A2020
- Author(s)
  Watanabe H, Enoki Y, Maruyama T
- Total Pages
  20
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20H03406
[Book] Uremic solutes and sarcopenia. Uremic toxins and organ failure, edited by Saito H and Abe T2020
- Author(s)
  Watanabe H, Kato H, Enoki Y, Maeda H, Maruyama T
- Total Pages
  18
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20H03406
[Book] 副甲状腺ホルモンの新しい標的臓器とその作用2017
- Author(s)
  丸山徹、渡邊博志、田中元子
- Total Pages
  6
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] 副甲状腺ホルモンによる高尿酸血症発症のメカニズム2017
- Author(s)
  渡邊博志、丸山徹
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] CKD-MBDにおけるリン吸着薬の進歩と治療選択～リンと鉄の関連を含めて～最新透析医療　先端技術との融合2016
- Author(s)
  田中元子、伊藤和子、奥田智子、今福匡史、渡邊博志、丸山徹、小泉賢洋、角田隆俊、深川雅史
- Total Pages
  3
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] タンパク結合率の臨床的な意義を教えて下さい。2016
- Author(s)
  渡邊博志、丸山徹
- Total Pages
  5
- Publisher
  じほう
- Data Source
  KAKENHI-PROJECT-25460190
[Book] CKD-MBDにおけるリン吸着薬の進歩と治療選択～リンと鉄の関連を含めて～最新透析医療　先端技術との融合2016
- Author(s)
  田中元子、伊藤和子、奥田智子、今福匡史、渡邊博志、丸山徹、小泉賢洋、角田隆俊、深川雅史
- Total Pages
  3
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-16K15320
[Book] Albumin as a biomarker. Human serum albumin: Pharmaceutical and medical applications, edited by Masaki Otagiri2016
- Author(s)
  Hiroshi Watanabe, Toru Maruyama
- Total Pages
  19
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] タンパク結合率の臨床的な意義を教えて下さい。2016
- Author(s)
  渡邊博志、丸山徹
- Total Pages
  5
- Publisher
  月刊薬事
- Data Source
  KAKENHI-PROJECT-16K15320
[Book] Albumin as a biomarker. Human serum albumin: Pharmaceutical and medical applications2016
- Author(s)
  Hiroshi Watanabe, Toru Maruyama
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25460190
[Book] タンパク結合率の臨床的な意義を教えて下さい。2016
- Author(s)
  渡邊博志、丸山徹
- Total Pages
  5
- Publisher
  月刊薬事
- Data Source
  KAKENHI-PROJECT-16H05114
[Book] Albumin as a biomarker Human serum albumin: Pharmaceutical and medical applications, edited by Masaki Otagiri2016
- Author(s)
  Hiroshi Watanabe, Toru Maruyama
- Total Pages
  19
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16K15320
[Book] 最新透析医療　先端技術との融合　CKD-MBDにおけるリン吸着薬の進歩と治療選択～リンと鉄の関連を含めて～2016
- Author(s)
  田中元子、伊藤和子、奥田智子、今福匡史、渡邊博志、丸山徹、小泉賢洋、角田隆俊、深川雅史
- Total Pages
  3
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] Contribution of the α1-acid glycoprotein in drug pharmacokinetics: the usefulness of α1-acid glycoprotein knock-out mice2024
- Author(s)
  2.Nakamura Y, Watanabe H, Imafuku T, Fujita I, Ganaha Y, Takeo T, Nakagata N, Maeda H, Maruyama T
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406
[Journal Article] Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation2024
- Author(s)
  Taguchi Kazuaki、Ogaki Shigeru、Maeda Hitoshi、Ishima Yu、Watanabe Hiroshi、Otagiri Masaki、Maruyama Toru
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 47 Issue: 4 Pages: 868-871
- DOI
  10.1248/bpb.b23-00917
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2024-04-20
- Language
  English
- Data Source
  KAKENHI-PROJECT-23K28431
[Journal Article] Carbon monoxide-loaded cell therapy as an exercise mimetic for sarcopenia treatment2024
- Author(s)
  Noguchi Isamu、Maeda Hitoshi、Kobayashi Kazuki、Nagasaki Taisei、Kato Hiromasa、Yanagisawa Hiroki、Wada Naoki、Kanazawa Gai、Kaji Tsubasa、Sakai Hiromi、Fujimaki Shin、Ono Yusuke、Taguchi Kazuaki、Chuang Victor Tuan Giam、Saruwatari Junji、Otagiri Masaki、Watanabe Hiroshi、Maruyama Toru
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 220 Pages: 67-77
- DOI
  10.1016/j.freeradbiomed.2024.04.231
- Data Source
  KAKENHI-PROJECT-23K28431
[Journal Article] Mouse Type-I Interferon-Mannosylated Albumin Fusion Protein for the Treatment of Chronic Hepatitis2024
- Author(s)
  Minayoshi Yuki、Maeda Hitoshi、Hamasaki Keisuke、Nagasaki Taisei、Takano Mei、Fukuda Ryo、Mizuta Yuki、Tanaka Motohiko、Sasaki Yutaka、Otagiri Masaki、Watanabe Hiroshi、Maruyama Toru
- Journal Title
  
  Pharmaceuticals
  
  Volume: 17 Issue: 2 Pages: 260-260
- DOI
  10.3390/ph17020260
- Data Source
  KAKENHI-PROJECT-23K28431
[Journal Article] Impaired Cholesterol Efflux Capacity rather than Low HDL-C Reflects Oxidative Stress under Acute Myocardial Infarction2024
- Author(s)
  Oniki Kentaro、Ogura Masatsune、Matsumoto Erika、Watanabe Hiroshi、Imafuku Tadashi、Seguchi Yuri、Arima Yuichiro、Fujisue Koichiro、Yamanaga Kenshi、Yamamoto Eiichiro、Maeda Hitoshi、Ogata Yasuhiro、Yoshida Minoru、Harada-Shiba Mariko、Maruyama Toru、Tsujita Kenichi、Saruwatari Junji
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 31 Issue: 8 Pages: 1149-1161
- DOI
  10.5551/jat.64691
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2024-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08143, KAKENHI-PROJECT-22K06700, KAKENHI-PROJECT-23K28431
[Journal Article] Albumin-fused thioredoxin ameliorates high-fat diet-induced non-alcoholic steatohepatitis2024
- Author(s)
  Murata R, Watanabe H, Iwakiri R, Chikamatsu M, Satoh T, Noguchi I, Yasuda K, Nishinoiri A, Yoshitake T, Nosaki H, Maeda H, Maruyama T
- Journal Title
  
  Heliyon
  
  Volume: 10 Issue: 3 Pages: e25485-e25485
- DOI
  10.1016/j.heliyon.2024.e25485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-23K28431
[Journal Article] Carbon Monoxide-Loaded Red Blood Cell Prevents the Onset of Cisplatin-Induced Acute Kidney Injury.2023
- Author(s)
  Nagasaki T, Maeda H, Yanagisawa H, Nishida K, Kobayashi K, Wada N, Noguchi I, Iwakiri R, Taguchi K, Sakai H, Saruwatari J, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Antioxidants (Basel).
  
  Volume: 12 Issue: 9 Pages: 1705-1705
- DOI
  10.3390/antiox12091705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K25213, KAKENHI-PROJECT-23K28431
[Journal Article] Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis2023
- Author(s)
  Yasuda K, Maeda H, Kinoshita R, Minayoshi Y, Mizuta Y, Nakamura Y, Imoto S, Nishi K, Yamasaki K, Sakuragi M, Nakamura T, Ikeda-Imafuku M, Iwao Y, Ishima Y, Ishida T, Iwakiri Y, Otagiri M, Watanabe H, Maruyama T
- Journal Title
  
  ACS Nano
  
  Volume: 17 Issue: 17 Pages: 16668-16681
- DOI
  10.1021/acsnano.3c02877
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-21H02645, KAKENHI-PROJECT-23K28431
[Journal Article] Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation2023
- Author(s)
  Arimura Nanaka、Watanabe Hiroshi、Kato Hiromasa、Imafuku Tadashi、Nakano Takehiro、Sueyoshi Miyu、Chikamatsu Mayuko、Tokumaru Kai、Nagasaki Taisei、Maeda Hitoshi、Tanaka Motoko、Matsushita Kazutaka、Maruyama Toru
- Journal Title
  
  Toxins
  
  Volume: 15 Issue: 3 Pages: 179-179
- DOI
  10.3390/toxins15030179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15315, KAKENHI-PROJECT-20H03406
[Journal Article] Therapeutic Effects of Albumin-Fused BMP7 on 2 Experimental Models of Liver Fibrosis2023
- Author(s)
  Takano M, Watanabe H, Toda S, Nishida K, Imafuku T, Minayoshi Y, Nakano T, Maeda H, Maruyama T
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 10 Pages: 1421-1426
- DOI
  10.1248/bpb.b23-00254
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-23K28431
[Journal Article] Oxidized Albumin: Evaluation of Oxidative Stress as a Marker for the Progression of Kidney Disease2022
- Author(s)
  Watanabe H
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 12 Pages: 1728-1732
- DOI
  10.1248/bpb.b22-00586
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406
[Journal Article] Engineering of a long-acting bone morphogenetic protein-7 by fusion with albumin for the treatment of renal injury2022
- Author(s)
  Takano M, Toda S, Watanabe H, Fujimura R, Nishida K, Bi J, Minayoshi Y, Miyahisa M, Maeda H, Maruyama T
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 7 Pages: 1334-1334
- DOI
  10.3390/pharmaceutics14071334
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19340, KAKENHI-PROJECT-21K15315
[Journal Article] Advanced oxidation protein products contribute to chronic kidney disease-induced muscle atrophy by inducing oxidative stress via CD36/NADPH oxidase pathway2021
- Author(s)
  Kato H, Watanabe H, Imafuku T, Arimura N, Fujita I, Noguchi I, Tanaka S, Nakano T, Tokumaru K, Enoki Y, Maeda H, Hino S, Tanaka M, Matsushita K, Fukagawa M, Maruyama T
- Journal Title
  
  J Cachexia Sarcopenia Muscle
  
  Volume: 12 Issue: 6 Pages: 1832-1847
- DOI
  10.1002/jcsm.12786
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-20H04108, KAKENHI-PROJECT-21K19513
[Journal Article] An acute phase protein alfa1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action2021
- Author(s)
  Hiroshi Watanabe*,#, Rui Fujimura*, Yuto Hiramoto*, Ryota Murata, Kento Nishida, Jing Bi, Tadashi Imafuku, Hisakazu Komori, Hitoshi Maeda, Ayumi Mukunoki, Toru Takeo, Naomi Nakagata, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama# *equal contribution; #equal correspondence
- Journal Title
  
  Sci Rep.
  
  Volume: 12;11(1) Issue: 1 Pages: 7953-7953
- DOI
  10.1038/s41598-021-87217-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18J23070, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-21K19340
[Journal Article] Indoxyl sulfate contributes to mTORC1-induced renal fibrosis via the OAT/NADPH oxidase/ROS pathway2021
- Author(s)
  Nakano T, Watanabe H, Imafuku T, Tokumaru K, Fujita I, Arimura N, Maeda H, Tanaka M, Matsushita K, Fukagawa M, Maruyama T
- Journal Title
  
  Toxins (Basel)
  
  Volume: 13 Issue: 12 Pages: 909-909
- DOI
  10.3390/toxins13120909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406
[Journal Article] Cysteinylated albumin as a potential biomarker for the progression of kidney disease in patients with type 2 diabetes2021
- Author(s)
  Imafuku T*, Watanabe H*#, Oniki K, Yoshida A, Kato H, Nakano T, Tokumaru K, Fujita I, Arimura N, Maeda H, Sakamoto Y, Kondo N, Morita A, Saruwatari J, Tanaka T, Matsushita K, Wada T, Fukagawa M, Otagiri M, Fitzgerald L. Michael, Jinnouchi H, Maruyama T# *equal contribution and #equal corresponding author
- Journal Title
  
  Diabetes Care
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03406
[Journal Article] Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin2021
- Author(s)
  Koji Nishi, Keiki Sakurama, Hiroshi Watanabe, Toru Maruyama, Keishi Yamasaki, Masaki Otagiri
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 3 Pages: 437-441
- DOI
  10.1248/bpb.b20-00929
- NAID
  130007993459
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20K06995
[Journal Article] Cysteinylated albumin as a potential biomarker for the progression of kidney disease in patients with type 2 diabetes2021
- Author(s)
  Imafuku T, Watanabe H, Oniki K, Yoshida A, Kato H, Nakano T, Tokumaru K, Fujita I, Arimura N, Maeda H, Sakamoto Y, Kondo N, Morita A, Saruwatari J, Tanaka M, Matsushita K, Wada T, Fukagawa M, Otagiri M, Fitzgerald ML, Jinnouchi H, Maruyama T.
- Journal Title
  
  Diabetes Care
  
  Volume: 26 Issue: 6 Pages: e115-e117
- DOI
  10.2337/dc20-3003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-19K07166, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-19H03557, KAKENHI-PROJECT-20K07134
[Journal Article] Advanced oxidation protein products contribute to renal tubulopathy via perturbation of renal fatty acids2020
- Author(s)
  Imafuku, T., Watanabe, H., Satoh, T., Matsuzaka, T., Inazumi, T., Kato, H., Tanaka, S., Nakamura, Y., Nakano, T., Tokumaru, K., Maeda, H., Tanaka, M., Matsushita, K., Tsuchiya, S., Sugimoto, Y., Shimano, H., Fukagawa, M., and Maruyama, T.
- Journal Title
  
  Kidney360
  
  Volume: 1 Issue: 8 Pages: 781-796
- DOI
  10.34067/kid.0000772019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22503, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-17H03990, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-18K14904
[Journal Article] α1-acid glycoprotein attenuates adriamycin-induced nephropathy via CD163 expressing macrophages induction2020
- Author(s)
  Fujimura, Watanabe H, Nishida K, Fujiwara Y, Koga T, Bi J, Imafuku T, Kobayashi K, Komori H, Miyahisa M, Maeda H, Tanaka M, Matsushita K, Wada T, Fukagawa M, Maruyama T
- Journal Title
  
  Kidney360
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604
[Journal Article] Effect of Cinacalcet on the Redox Status of Albumin in Secondary Hyperparathyroidism Patients Receiving Hemodialysis2020
- Author(s)
  Imafuku Tadashi、Tanaka Motoko、Tokunaga Koki、Miyamura Shigeyuki、Kato Hiromasa、Tanaka Shoma、Nakano Takehiro、Hirata Kenshiro、Kadowaki Daisuke、Maeda Hitoshi、Matsushita Kazutaka、Otagiri Masaki、Komaba Hirotaka、Fukagawa Masafumi、Watanabe Hiroshi、Maruyama Toru
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 10 Pages: 1583-1590
- DOI
  10.1248/bpb.b20-00472
- NAID
  130007920876
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-18K06774
[Journal Article] Carbon monoxide rescues the developmental lethality of experimental rat models of rhabdomyolysis-induced acute kidney injury2020
- Author(s)
  Taguchi K, Ogaki S, Nagasaki T, Yanagisawa H, Nishida K, Maeda H, Enoki Y, Matsumoto K, Sekijima H, Ooi K, Ishima Y, Watanabe H, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 372(3) Issue: 3 Pages: 355-365
- DOI
  10.1124/jpet.119.262485
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-18H02587
[Journal Article] Effects of surface-deacetylated chitin nanofibers on non-alcoholic steatohepatitis model rats and their gut microbiota2020
- Author(s)
  Goto Miwa、Iohara Daisuke、Michihara Akihiro、Ifuku Shinsuke、Azuma Kazuo、Kadowaki Daisuke、Maruyama Toru、Otagiri Masaki、Hirayama Fumitoshi、Anraku Makoto
- Journal Title
  
  International Journal of Biological Macromolecules
  
  Volume: 164 Pages: 659-666
- DOI
  10.1016/j.ijbiomac.2020.07.184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KT0010, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18K06774
[Journal Article] A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein2020
- Author(s)
  Watanabe Hiroshi、Bi Jing、Murata Ryota、Fujimura Rui、Nishida Kento、Imafuku Tadashi、Nakamura Yuka、Maeda Hitoshi、Mukunoki Ayumi、Takeo Toru、Nakagata Naomi、Kurauchi Yuki、Katsuki Hiroshi、Tanaka Motoko、Matsushita Kazutaka、Fukagawa Masafumi、Maruyama Toru
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 11424-11424
- DOI
  10.1038/s41598-020-68337-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20H04126
[Journal Article] Changes in redox state of albumin before and after kidney transplantation in patients with end-stage renal disease2020
- Author(s)
  Ryota Tanaka, Tadashi Imafuku, Yosuke Suzuki, Kento Nishida, Kotaro Matsusaka, Toshitaka Shin, Yuhki Sato, Yu Ishima, Hiroshi Watanabe, Hiromitsu Mimata, Toru Maruyama, Hiroki Itoh
- Journal Title
  
  Clin Biochem
  
  Volume: 81 Pages: 20-26
- DOI
  10.1016/j.clinbiochem.2020.04.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18H02587
[Journal Article] Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice2020
- Author(s)
  Kento Nishida*, Hiroshi Watanabe*,#, Masako Miyahisa, Yuto Hiramoto, Hiroto Nosaki, Rui Fujimura, Hitoshi Maeda, Masaki Otagiri, Toru Maruyama# *equal contribution; #equal correspondence
- Journal Title
  
  Sci Rep
  
  Volume: 26;10(1): Issue: 1 Pages: 20635-20635
- DOI
  10.1038/s41598-020-75025-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604
[Journal Article] Characterization of the Interaction of Daptomycin With Site II on Human Serum Albumin2020
- Author(s)
  Yamasaki Keishi、Sakurama Keiki、Nishi Koji、Watanabe Hiroshi、Maruyama Toru、Seo Hakaru、Otagiri Masaki、Taguchi Kazuaki
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 109 Issue: 9 Pages: 2919-2924
- DOI
  10.1016/j.xphs.2020.06.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20K06995
[Journal Article] Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice2020
- Author(s)
  Nishida K, Watanabe H, Miyahisa M, Hiramoto Y, Nosaki H, Fujimura R, Maeda H, Otagiri M, and Maruyama M
- Journal Title
  
  Sci Rep.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Indoxyl sulfate contributes to adipose tissue inflammation through the activation of NADPH oxidase2020
- Author(s)
  Shoma Tanaka*, Hiroshi Watanabe*,#, Takehiro Nakano, Tadashi Imafuku, Hiromasa Kato, Kai Tokumaru, Nanaka Arimura, Yuki Enoki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama# *equal contribution; #equal correspondence
- Journal Title
  
  Toxins (Basel)
  
  Volume: 5;12(8): Issue: 8 Pages: 502-502
- DOI
  10.3390/toxins12080502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-20H03406, KAKENHI-PROJECT-18K15069
[Journal Article] α1-acid glycoprotein attenuates adriamycin-induced nephropathy via CD163 expressing macrophages induction2020
- Author(s)
  Fujimura R, Watanabe H, Nishida K, Fujiwara Y, Koga T, Bi J, Imafuku T, Kobayashi K, Komori H, Miyahisa M, Maeda H, Tanaka M, Matsushita K, Wada T, Fukagawa M, Maruyama .
- Journal Title
  
  Kidney360
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions2020
- Author(s)
  Oniki K, Kawakami T, Nakashima A, Miyata K, Watanabe T, Fujikawa H, Nakashima R, Nasu A, Eto Y, Takahashi N, Nohara H, Suico MA, Kotani S, Obata Y, Sakamoto Y, Seguchi Y, Saruwatari J, Imafuku T, Watanabe H, Maruyama T, Kai H, Shuto T
- Journal Title
  
  Sci Rep
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604
[Journal Article] The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models2020
- Author(s)
  Abdullah-Al-Shoeb Mohammad、Sasaki Kenta、Kikutani Saori、Namba Nanami、Ueno Keiichi、Kondo Yuki、Maeda Hitoshi、Maruyama Toru、Irie Tetsumi、Ishitsuka Yoichi
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 10 Pages: 965-965
- DOI
  10.3390/antiox9100965
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07066, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604
[Journal Article] Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice2020
- Author(s)
  Nishida K, Watanabe H, Miyahisa M, Hiramoto Y, Nosaki H, Fujimura R, Maeda H, Otagiri M, and Maruyama M
- Journal Title
  
  Sci Rep
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604
[Journal Article] In vivo evaluation of drug dialyzability in a rat model of hemodialysis.2020
- Author(s)
  Fukunaga M, Kadowaki D, Mori M, Hagiwara S, Narita Y, Saruwatari J, Tanaka R, Watanabe H, Yamasaki K, Taguchi K, Ito H, Maruyama T, Otagiri M, Hirata S.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 6 Pages: 20-26
- DOI
  10.1371/journal.pone.0233925
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18K06774
[Journal Article] Repeated Administration of Kupffer Cells-Targeting Nanoantioxidant Ameliorates Liver Fibrosis in an Experimental Mouse Model2020
- Author(s)
  Maeda H, Minayoshi Y, Ichimizu S, Mizuta Y, Nagasaki T, Matsusaka K, Oshiro S, Oniki K, Saruwatari J, Ishima Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 43 Issue: 1 Pages: 93-101
- DOI
  10.1248/bpb.b19-00599
- NAID
  130007779193
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2020-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07166, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-17K15511, KAKENHI-PROJECT-18H02587
[Journal Article] The DsbA-L gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties2020
- Author(s)
  Oniki K, Nohara H, Nakashima R, Obata Y, Muto N, Sakamoto Y, Ueno-Shuto K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Suico MA, Kai H, Shuto T, and Saruwatari J
- Journal Title
  
  Sci Rep
  
  Volume: －
- NAID
  120007146111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604
[Journal Article] The<I> DsbA-L</I> gene is associated with respiratory function of the elderly via its adiponectin multimeric or antioxidant properties.2020
- Author(s)
  Kentaro Oniki, Hirofumi Nohara, Ryunosuke Nakashima, Yui Obata, Narumi Muto, Yuki Sakamoto, Keiko Ueno-Shuto, Tadashi Imafuku, Yu Ishima, Hiroshi Watanabe, Toru Maruyama, Koji Otake, Yasuhiro Ogata, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto, and Junji Saruwatari.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 5973-5973
- DOI
  10.1038/s41598-020-62872-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07114, KAKENHI-PROJECT-19K07166, KAKENHI-PROJECT-20K07134, KAKENHI-PROJECT-20K21485
[Journal Article] α1-acid glycoprotein attenuates adriamycin-induced nephropathy via CD163 expressing macrophages induction2020
- Author(s)
  Fujimura Rui、Watanabe Hiroshi、Nishida Kento、Fujiwara Yukio、Koga Tomoaki、Bi Jing、Imafuku Tadashi、Kobayashi Kazuki、Komori Hisakazu、Miyahisa Masako、Maeda Hitoshi、Tanaka Motoko、Matsushita Kazutaka、Wada Takashi、Fukagawa Masafumi、Maruyama Toru
- Journal Title
  
  Kidney360
  
  Volume: ー Issue: 5 Pages: 343-353
- DOI
  10.34067/kid.0000782019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J23070, KAKENHI-PROJECT-17K08664, KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604
[Journal Article] Development of a long acting FGF21 analogue-albumin fusion protein and its anti-diabetic effects2020
- Author(s)
  Hiroshi Watanabe*,#, Masako Miyahisa*, Mayuko Chikamatsu*, Kento Nishida, Yuki Minayoshi, Mei Takano, Shota Ichimizu, Yoshihiro Kobashigawa, Hiroshi Morioka, Hitoshi Maeda, Toru Maruyama# *equal contribution; #equal correspondence
- Journal Title
  
  J Control Release
  
  Volume: 10;324: Pages: 522-531
- DOI
  10.1016/j.jconrel.2020.05.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21485, KAKENHI-PROJECT-18H02604
[Journal Article] Effect of Serum Parathyroid Hormone on Tacrolimus Therapy in Kidney Transplant Patients: A Possible Biomarker for a Tacrolimus Dosage Schedule2019
- Author(s)
  Hirata K, Watanabe H, Toyoda M, Sugimoto R, Ikegami K, Imafuku T, Matsuzaka K, Ichimizu S, Maeda H, Uekihara S, Jingami S, Maruyama T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 5 Pages: 786-791
- DOI
  10.1248/bpb.b18-00976
- NAID
  130007641447
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-18H02604
[Journal Article] Effect of serum parathyroid hormone on tacrolimus therapy in kidney transplant patients：A possible biomarker for a tacrolimus dosage schedule2019
- Author(s)
  Hirata K, Watanabe H, Toyoda M, Sugimoto R, Ikegami K, Imafuku T, Matsuzaka K, Ichimizu S, Maeda H, Uekihara S, Jingami S and Maruyama T
- Journal Title
  
  Biol Pharm Bull
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Unique Hydrolysis of an Ester-Type Prodrug of Levodopa in Human Plasma: Relay-Type Role Sharing between Alpha-1 Acid Glycoprotein and Human Serum Albumin2019
- Author(s)
  Kono K, Fukuchi Y, Okawa H, Nunoya KI, Imawaka H, Watanabe H, Maruyama T.
- Journal Title
  
  Mol Pharm.
  
  Volume: 16(10) Issue: 10 Pages: 4131-4138
- DOI
  10.1021/acs.molpharmaceut.9b00435
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02604
[Journal Article] α1-Acid Glycoprotein Has the Potential to Serve as a Biomimetic Drug Delivery Carrier for Anticancer Agents.2019
- Author(s)
  Matsusaka K, Ishima Y, Maeda H, Kinoshita R, Ichimizu S, Taguchi K, Giam Chuang VT, Nishi K, Yamasaki K, Otagiri M, Watanabe H, Maruyama T
- Journal Title
  
  J Pharm Sci.
  
  Volume: 108(11) Issue: 11 Pages: 3592-3598
- DOI
  10.1016/j.xphs.2019.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-17K08261
[Journal Article] Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape2019
- Author(s)
  Ichimizu Shota、Watanabe Hiroshi、Maeda Hitoshi、Hamasaki Keisuke、Ikegami Komei、Chuang Victor Tuan Giam、Kinoshita Ryo、Nishida Kento、Shimizu Taro、Ishima Yu、Ishida Tatsuhiro、Seki Takahiro、Katsuki Hiroshi、Futaki Shiroh、Otagiri Masaki、Maruyama Toru
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 304 Pages: 156-163
- DOI
  10.1016/j.jconrel.2019.05.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-19K07123, KAKENHI-PROJECT-16H04673, KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604
[Journal Article] Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment2019
- Author(s)
  Ishima Yu、Mimono Ai、Tuan Giam Chuang Victor、Fukuda Tetsuya、Kusumoto Kohshi、Okuhira Keiichiro、Suwa Yoshiaki、Watanabe Hiroshi、Ishida Tatsuhiro、Morioka Hiroshi、Maruyama Toru、Otagiri Masaki
- Journal Title
  
  IUBMB Life
  
  Volume: 72 Issue: 4 Pages: 641-651
- DOI
  10.1002/iub.2203
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-20H04124
[Journal Article] S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics2019
- Author(s)
  Ishima Yu、Watanabe Kaori、Chuang Victor T. G.、Takeda Iyo、Kuroda Teruo、Ogawa Wakano、Watanabe Hiroshi、Iwao Yasunori、Ishida Tatsuhiro、Otagiri Masaki、Maruyama Toru
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Issue: 3 Pages: 137-150
- DOI
  10.1096/fba.1018
- NAID
  120007153321
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604
[Journal Article] Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape.2019
- Author(s)
  Ichimizu S, Watanabe H, Maeda H, Hamasaki K, Ikegami K, Chuang VTG, Kinoshita R, Nishida K, Shimizu T, Ishima Y, Ishida T, Seki T, Katsuki H, Futaki S, Otagiri M, Maruyama T
- Journal Title
  
  J Control Release.
  
  Volume: S0168-3659 Pages: 30174-30177
- DOI
  10.1016/j.jconrel.2020.03.022
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Sarcopenia in Chronic Kidney Disease: Factors, Mechanisms, and Therapeutic Interventions2019
- Author(s)
  Watanabe H, Enoki Y, Maruyama T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 9 Pages: 1437-1445
- DOI
  10.1248/bpb.b19-00513
- NAID
  130007700086
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-09-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities2019
- Author(s)
  Ikeda Mayumi、Ishima Yu、Chuang Victor T. G.、Sakai Maki、Osafune Hiroki、Ando Hidenori、Shimizu Taro、Okuhira Keiichiro、Watanabe Hiroshi、Maruyama Toru、Otagiri Masaki、Akaike Takaaki、Ishida Tatsuhiro
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 9 Pages: 1689-1689
- DOI
  10.3390/molecules24091689
- NAID
  120006995454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18J10935, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18H05277
[Journal Article] Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity.2018
- Author(s)
  Taguchi K, Nagao S, Maeda H, Yanagisawa H, Sakai H, Yamasaki K, Wakayama T, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  Drug Deliv
  
  Volume: 25 Issue: 1 Pages: 1266-1274
- DOI
  10.1080/10717544.2018.1477860
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08261, KAKENHI-PROJECT-17K08481, KAKENHI-PROJECT-18H02604
[Journal Article] A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis,2018
- Author(s)
  Ikeda M, Ishima Y, Kinoshita R, Chuang VTG, Tasaka N, Matsuo N, Watanabe H, Shimizu T, Ishida T, Otagiri M, Maruyama T,
- Journal Title
  
  Redox Biology
  
  Volume: 14 Pages: 354-360
- DOI
  10.1016/j.redox.2017.10.007
- NAID
  120007029979
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-15K08076, KAKENHI-PROJECT-18J10935, KAKENHI-PROJECT-18H02587
[Journal Article] 尿毒症物質パラクレジル硫酸によるNADPH oxidase活性化を介した尿細管および血管障害作用2018
- Author(s)
  渡邊博志
- Journal Title
  
  腎とフリーラジカル　第13集
  
  Volume: 13 Pages: 64-66
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Role of parathyroid hormone in regulating transporter and metabolizing enzyme function2018
- Author(s)
  Watanabe H, Maruyama T
- Journal Title
  
  Therapeutic Apheresis and Dialysis
  
  Volume: 22 Pages: 251-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] 尿毒症物質2018
- Author(s)
  渡邊博志、丸山徹
- Journal Title
  
  透析患者の検査値の読み方　改訂第4版
  
  Volume: 4 Pages: 221-223
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Dual therapeutic effects of an albumin-based nitric oxide donor on two experimental models of chronic kidney disease2018
- Author(s)
  Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 107 Issue: 3 Pages: 848-855
- DOI
  10.1016/j.xphs.2017.10.023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-15K08076, KAKENHI-PROJECT-16K15320, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18J10935, KAKENHI-PROJECT-18H02587
[Journal Article] A downstream molecule of 1,25-dihydroxyvitamin D3, alpha-1-acid glycoprotein, protects against mouse model of renal fibrosis2018
- Author(s)
  Bi J, Watanabe H, Fujimura R, Nishida K, Nakamura R, Oshiro S, Imafuku T, Komori H, Miyahisa M, Tanaka M, Matsushita K, Maruyama T
- Journal Title
  
  Sci Rep
  
  Volume: 26 Issue: 1 Pages: 17329-17329
- DOI
  10.1038/s41598-018-35339-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-17J11624
[Journal Article] Clinical Implications Associated With the Posttranslational Modification-Induced Functional Impairment of Albumin in Oxidative Stress-Related Diseases.2017
- Author(s)
  Watanabe H, Imafuku T, Otagiri M, Maruyama T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: S0022-3549 Issue: 9 Pages: 18-25
- DOI
  10.1016/j.xphs.2017.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-16K15320, KAKENHI-PROJECT-17J11624
[Journal Article] Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction2017
- Author(s)
  Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku K, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  J Cachexia Sarcopenia Muscle
  
  Volume: 8 Issue: 5 Pages: 735-747
- DOI
  10.1002/jcsm.12202
- NAID
  120006869527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism2017
- Author(s)
  Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 145 Pages: 192-201
- DOI
  10.1016/j.bcp.2017.08.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15320
[Journal Article] Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach2017
- Author(s)
  keda, M. Ishima, Y. Shibata, A. Chuang, V. T. G. Sawa, T. Ihara, H. Watanabe, H. Xian, M. Ouchi, Y. Shimizu, T. Ando, H. Ukawa, M. Ishida, T. Akaike, T. Otagiri, M. Maruyama, T.
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 969 Pages: 18-25
- DOI
  10.1016/j.aca.2017.03.027
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04674, KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-17K19205, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H03115, KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-15K08076, KAKENHI-PROJECT-16K15208
[Journal Article] The down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism2017
- Author(s)
  Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Kidney Int
  
  Volume: 91 Pages: 658-670
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] The down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism2017
- Author(s)
  Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura M, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Toru Maruyama
- Journal Title
  
  Kidney Int
  
  Volume: 91 Issue: 3 Pages: 658-670
- DOI
  10.1016/j.kint.2016.09.041
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15320, KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-16H05114
[Journal Article] Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction2017
- Author(s)
  Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, , Imafuku T, Nishida T, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  J Cachexia Sarcopenia Muscle
  
  Volume: 印刷中
- NAID
  120006869527
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-Nitrosated Human Serum Albumin Dimer.2017
- Author(s)
  Kinoshita R, Ishima Y, Chuang VTG, Nakamura H, Fang J, Watanabe H, Shimizu T, Okuhira K, Ishida T, Maeda H, Otagiri M, Maruyama T.
- Journal Title
  
  Biomaterials.
  
  Volume: 140 Pages: 162-169
- DOI
  10.1016/j.biomaterials.2017.06.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-15K08076
[Journal Article] Human Serum Albumin Hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease2016
- Author(s)
  Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VTG, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T
- Journal Title
  
  Biochem Biophys Res Comm
  
  Volume: 479 Pages: 578-583
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations2016
- Author(s)
  Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci.
  
  Volume: 105 Issue: 3 Pages: 1043-1049
- DOI
  10.1016/j.xphs.2015.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-26460248, KAKENHI-PROJECT-26670569
[Journal Article] Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease2016
- Author(s)
  Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VT, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 479 Issue: 3 Pages: 578-583
- DOI
  10.1016/j.bbrc.2016.09.113
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-15K08076
[Journal Article] Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study2016
- Author(s)
  Tanaka M, Miyamura S, Imafuku T, Tominaga Y, Maeda H, Anraku M, Yamasaki K, Kadowaki D, Ishima Y, Watanabe H, Okuda T, Itoh K, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 6 Pages: 1000-1006
- DOI
  10.1248/bpb.b15-01021
- NAID
  130005155137
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-26460248, KAKENHI-PROJECT-15K08100
[Journal Article] Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease2016
- Author(s)
  Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VTG, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T
- Journal Title
  
  Biochem Biophys Res Comm
  
  Volume: 479 Pages: 578-583
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] Carbon monoxide-bound hemoglobin vesicles ameliorate multiorgan injuries induced by severe acute pancreatitis in mice by their anti-inflammatory and antioxidant properties2016
- Author(s)
  Nagao S, Taguchi K, Sakai H, Yamasaki K, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 11 Pages: 5611-5620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15320
[Journal Article] Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-12016
- Author(s)
  Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Sci Rep
  
  Volume: 6 Issue: 1 Pages: 32084-32084
- DOI
  10.1038/srep32084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-16H05114, KAKENHI-PROJECT-15K15185, KAKENHI-PROJECT-16K08168, KAKENHI-PROJECT-16K15320
[Journal Article] The clinical significance of plasma neopterin in heart failure with preserved left ventricular ejection fraction2016
- Author(s)
  Yamamoto E, Hirata Y, Tokitsu T, Kusaka H, Tabata N, Tsujita K, Yamamuro M, Kaikita K, Watanabe H, Hokimoto S, Maruyama T, Ogawa H
- Journal Title
  
  ESC Heart Failure
  
  Volume: 3 Pages: 53-59
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Carbon monoxide-bound hemoglobin-vesicles ameliorates multi-organ injuries induced by severe acute pancreatitis in mice via their anti-inflammatory and anti-oxidant properties2016
- Author(s)
  Nagao S, Taguchi K, Sakai H, Yamasaki K, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 11 Pages: 5611-5620
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] Carbon monoxide-bound hemoglobin-vesicles ameliorates multi-organ injuries induced by severe acute pancreatitis in mice via their anti-inflammatory and anti-oxidant properties2016
- Author(s)
  Nagao S, Taguchi K, Sakai H, Yamasaki K, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 11 Pages: 5611-5620
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations2016
- Author(s)
  Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Pages: 1043-1049
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05114
[Journal Article] Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis2016
- Author(s)
  Nagao S, Taguchi K, Miyazaki Y, Wakayama T, Chuang VT, Yamasaki K, Watanabe H, Sakai H, Otagiri M, Maruyama T
- Journal Title
  
  J Control Release
  
  Volume: 234 Pages: 49-58
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.2015
- Author(s)
  Watanabe H, Miyamoto Y, Enoki Y, Ishima Y, Kadowaki D, Kotani S, Nakajima M, Tanaka M, Matsushita K, Mori Y, Kakuta T, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Pharmacol Res Perspect
  
  Volume: 3 Issue: 1
- DOI
  10.1002/prp2.92
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25460652
[Journal Article] Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy via the generation of nitric oxide2015
- Author(s)
  Ishima Y, Inoue A, Fang J, Kinoshita R, Ikeda M, Watanabe H, Maeda H, Otagiri M, Maruyama T
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Pages: 194-200
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model2015
- Author(s)
  Taguchi K, Hashimoto M, Ogaki S, Watanabe H, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 104 Pages: 3084-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] The pivotal role of eNOS uncoupling in vascular endothelial dysfunction in patients with heart failure with preserved ejection fraction2015
- Author(s)
  Yamamoto E, Hirata Y, Tokitsu T, Kusaka H, Sakamoto K, Yamamuro M, Kaikita K, Watanabe H, Hokimoto S, Sugiyama S, Maruyama T, Ogawa H
- Journal Title
  
  Int J Cardiol.
  
  Volume: 190 Pages: 335-337
- DOI
  10.1016/j.ijcard.2015.04.162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models2015
- Author(s)
  Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VTG, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Exp Ther
  
  Volume: 352 Pages: 244-57
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes2015
- Author(s)
  Kinoshita R, Ishima Y, Ikeda M, Kragh-Hansen U, Fang J, Nakamura H, Chuang VTG, Tanaka R, Maeda H, Kodama A, Watanabe H, Maeda H, Otagiri M, Maruyama T
- Journal Title
  
  J Control Release
  
  Volume: 217 Pages: 1-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia2015
- Author(s)
  Hashimoto M, Taguchi K, Ogaki S, Watanabe H, Kinoshita M, Nishikawa K, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 105 Pages: 3968-76
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models2015
- Author(s)
  Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VTG, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Exp Ther
  
  Volume: 352 Pages: 244-57
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury.2015
- Author(s)
  Nishida K, Watanabe H, Ogaki S, Kodama A, Tanaka R, Imafuku T, Ishima Y, Giam Chuang VT, Toyoda M, Kondoh M, Wu Q, Fukagawa M, Otagiri M, Maruyama T.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Issue: 1 Pages: 14471-14471
- DOI
  10.1038/srep14471
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15008, KAKENHI-PROJECT-15K15185, KAKENHI-PROJECT-15H04758
[Journal Article] Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy via the generation of nitric oxide2015
- Author(s)
  Ishima Y, Inoue A, Fang J, Kinoshita R, Ikeda M, Watanabe H, Maeda H, Otagiri M, Maruyama T
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Pages: 194-200
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes2015
- Author(s)
  Kinoshita R, Ishima Y, Ikeda M, Kragh-Hansen U, Fang J, Nakamura H, Chuang VTG, Tanaka R, Maeda H, Kodama A, Watanabe H, Maeda H, Otagiri M, Maruyama T
- Journal Title
  
  J Control Release
  
  Volume: 217 Pages: 1-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Journal Article] Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.2015
- Author(s)
  Ishima Y, Inoue A, Fang J, Kinoshita R, Ikeda M, Watanabe H, Maeda H, Otagiri M, Maruyama T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 Issue: 2 Pages: 194-200
- DOI
  10.1111/cas.12577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-25860118, KAKENHI-PROJECT-15K08076
[Journal Article] Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model2015
- Author(s)
  Taguchi K, Hashimoto M, Ogaki S, Watanabe H, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 104 Pages: 3084-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Continuous Reduction of Protein-Bound Uraemic Toxins with Improved Oxidative Stress by Using the Oral Charcoal Adsorbent AST-120 in Haemodialysis Patients.2015
- Author(s)
  Yamamoto S, Kazama JJ, Omori K, Matsuo K, Takahashi Y, Kawamura K, Matsuto T, Watanabe H, Maruyama T, Narita I.
- Journal Title
  
  Sci Rep.
  
  Volume: N/A Issue: 1 Pages: 14381-14381
- DOI
  10.1038/srep14381
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09249, KAKENHI-PROJECT-26670429, KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25460652, KAKENHI-PROJECT-26293201
[Journal Article] Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nano-antioxidant for the treatment of two acute hepatitis models.2015
- Author(s)
  Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 352 Issue: 2 Pages: 244-257
- DOI
  10.1124/jpet.114.219493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-15K08076, KAKENHI-PROJECT-26670569, KAKENHI-PROJECT-25293173, KAKENHI-PROJECT-25293369
[Journal Article] Pharmacokinetic Properties of Single and Repeated Injection of Liposomal Platelet Substitute in a Rat Model of Red Blood Cell Transfusion-Induced Dilutional Thrombocytopenia2015
- Author(s)
  Hashimoto M, Taguchi K, Ogaki S, Watanabe H, Kinoshita M, Nishikawa K, Takeoka S, Ikeda Y, Handa M, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 104 Pages: 3968-76
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Journal Article] Albumin Fusion Prolongs the Antioxidant and Anti-Inflammatory Activities of Thioredoxin in Mice with Acetaminophen-Induced Hepatitis.2014
- Author(s)
  Tanaka R, Ishima Y, Maeda H, Kodama A, Nagao S, Watanabe H, Chuang VT, Otagiri M, Maruyama T.
- Journal Title
  
  Mol Pharm.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043
[Journal Article] Effects of chitosan on oxidative stress and related factors in hemodialysis patients.2014
- Author(s)
  Anraku M, Tanaka M, Hiraga A, Nagumo K, Imafuku T, Maezaki Y, Iohara D, Uekama K, Watanabe H, Hirayama F, Maruyama T, Otagiri M
- Journal Title
  
  Carbohydr Polym
  
  Volume: 112 Pages: 152-157
- DOI
  10.1016/j.carbpol.2014.05.078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26460248
[Journal Article] Tuning of Poly-S-Nitrosated Human Serum Albumin as Superior Antitumor Nanomedicine2014
- Author(s)
  Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 103 Issue: 7 Pages: 2184-2188
- DOI
  10.1002/jps.24020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-25860118
[Journal Article] Therapeutic Impact of Human Serum Albumin-Thioredoxin Fusion Protein on Influenza Virus-Induced Lung Injury Mice.2014
- Author(s)
  Tanaka R, Ishima Y, Enoki Y, Kimachi K, Shirai T, Watanabe H, Chuang VT, Maruyama T, Otagiri M.
- Journal Title
  
  Front Immunol
  
  Volume: 5 Pages: 561-561
- DOI
  10.3389/fimmu.2014.00561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-25860118
[Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases2014
- Author(s)
  K. Nagumo, M. Tanaka, VT. Chuang, H. Setoyama, H. Watanabe, N. Yamada, K. Kubota, M. Tanaka, K. Matsushita, A. Yoshida, H. Jinnouchi, M. Anraku, D. Kadowaki, Y. Ishima, Y. Sasaki, M. Otagiri, T. Maruyama.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e85216-e85216
- DOI
  10.1371/journal.pone.0085216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23790211, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25860118, KAKENHI-PROJECT-26460248
[Journal Article] Albumin Fusion Prolongs the Antioxidant and Anti-Inflammatory Activities of Thioredoxin in Mice with Acetaminophen-Induced Hepatitis.2014
- Author(s)
  Tanaka R, Ishima Y, Maeda H, Kodama A, Nagao S, Watanabe H, Chuang VT, Otagiri M, Maruyama T.
- Journal Title
  
  Mol Pharm.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670085
[Journal Article] Carbon　monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by　massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450　protection in hemorrhagic shock rats.2014
- Author(s)
  Ogaki S, Taguchi K, Watanabe H, Ishima Y, Otagiri M, Maruyama T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 103 Issue: 7 Pages: 2199-2206
- DOI
  10.1002/jps.24029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860121
[Journal Article] Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.2014
- Author(s)
  Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1840 Issue: 3 Pages: 1152-1162
- DOI
  10.1016/j.bbagen.2013.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-25460190, KAKENHI-PROJECT-25670085
[Journal Article] Carbon monoxide-bound hemoglobin-vesicles for the　treatment of bleomycin-induced pulmonary fibrosis.2014
- Author(s)
  Nagao S, Taguchi K, Sakai H, Tanaka R, Horinouchi H, Watanabe H, Kobayashi K, Otagiri M, Maruyama T.
- Journal Title
  
  Biomaterials.
  
  Volume: 35 Issue: 24 Pages: 6553-6562
- DOI
  10.1016/j.biomaterials.2014.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24790159, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-26860121
[Journal Article] Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia.2014
- Author(s)
  Miyazaki Y, Taguchi K, Sou K, Watanabe H, Ishima Y, Miyakawa T, Mitsuya H,　Fukagawa M, Otagiri M, Maruyama T.
- Journal Title
  
  Mol Pharm.
  
  Volume: 11 Issue: 11 Pages: 4238-4248
- DOI
  10.1021/mp500453a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-25670085, KAKENHI-PROJECT-25860118, KAKENHI-PROJECT-26860121
[Journal Article] Albumin Fusion Prolongs the Antioxidant and Anti-Inflammatory Activities of Thioredoxin in Mice with Acetaminophen-Induced Hepatitis2014
- Author(s)
  Tanaka R, Ishima Y, Maeda H, Kodama A, Nagao S, Watanabe H, Chuang VT, Otagiri M, Maruyama T
- Journal Title
  
  Mol Pharm
  
  Volume: 印刷中 Issue: 4 Pages: 1228-1228
- DOI
  10.1021/mp400690v
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-25860118
[Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase.2013
- Author(s)
  Watanabe H, Miyamoto Y, Honda D, Tanaka H, Wu Q, Endo M, Noguchi T, Kadowaki D, Ishima Y, Kotani S, Nakajima M, Kataoka K, Kim-Mitsuyama S, Tanaka M, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Kidney Int
  
  Volume: 83 Pages: 582-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] Long-acting human serumalbumin-thioredoxin fusion proteinsuppresses bleomycin-inducedpulmonary fibrosis progression2013
- Author(s)
  Tanaka R, Watanabe H, Kodama A, ChuangVT, Ishima Y, Hamasaki K, Tanaka KI,Mizushima T, Otagiri M, Maruyama T
- Journal Title
  
  JPharmacol Exp Ther
  
  Volume: 345 Pages: 271-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38 MAPK pathways2013
- Author(s)
  Tanaka H, Iwasaki Y, Yamato H, Mori Y, Komaba H, Watanabe H, Maruyama T, Fukagawa M
- Journal Title
  
  Bone
  
  Volume: 56 Pages: 347-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] p-Cresylsulfate causes renal tubular celldamage by inducing oxidative stressthrough the activation of NADPHoxidase2013
- Author(s)
  Watanabe H, Miyamoto M, Honda D, TanakaH, Wu Q, Endo M, Noguchi T, Kadowaki D,Ishima Y, Kotani S, Nakajima M, KataokaK, Kim-Mitsuyama S, Tanaka M, FukagawaM, Otagiri M, Maruyama M
- Journal Title
  
  Kidney Int
  
  Volume: 83 Pages: 582-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy.2013
- Author(s)
  Kodama A
- Journal Title
  
  Kidney Int.
  
  Volume: 印刷中 Issue: 3 Pages: 446-54
- DOI
  10.1038/ki.2012.429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-23790187, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] Carbon Monoxide Bound Red Blood Cells Protect Red Blood Cell Transfusion-induced Hepatic Cytochrome P450 Impairment in Hemorrhagic-shock Rats. Drug Metab Dispos.2013
- Author(s)
  Ogaki S, Taguchi K, Watanabe H, Otagiri M, and Maruyama T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 41 Issue: 1 Pages: 141-8
- DOI
  10.1124/dmd.112.048744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24790159
[Journal Article] S-nitrosylated a-l-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis2013
- Author(s)
  Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, and Maruyama T.
- Journal Title
  
  FASEB J
  
  Volume: 27 Issue: 1 Pages: 391-398
- DOI
  10.1096/fj.12-217794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-22590064, KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23651239, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-25220103
[Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress byactivation of NADPH oxidase.2013
- Author(s)
  Hiroshi Watanabe^*, Yohei Miyamoto^*,Daisuke Honda, Hisae Tariaka, Qiong Wu,Masayuki Endo, Tsuyoshi Noguchi, DaisukeKadowaki, Yu Ishima, Shunsuke Kotani,Makoto Nakajima, Keiichiro Kataoka,Shokei Kim-Mitsuyama, Motoko Tanaka,Masafumi Fukagawa, Masaki Otagiri, ToruMaruyama. (^*:Hiroshi Watanabe and YoheiMiyamoto contributed equally to this work.)
- Journal Title
  
  Kidney International
  
  Volume: (印刷中) Issue: 4 Pages: 582-592
- DOI
  10.1038/ki.2012.448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05768, KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390058, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23790187, KAKENHI-PROJECT-24659076
[Journal Article] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy2013
- Author(s)
  Kodama A, Watanabe H, Tanaka R, Tanaka H, Chuang VT, Miyamoto Y, Wu Q, Endo M, Hamasaki K, Ishima Y, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  Kidney Int
  
  Volume: 83 Pages: 446-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression2013
- Author(s)
  Tanaka R, Watanabe H, Kodama A, Chuang VT, Ishima Y, Hamasaki K, Tanaka K, Mizushima T, Otagiri M, Maruyama T
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 345 Pages: 271-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460190
[Journal Article] Interaction between two sulfate-conjugated uremic toxins, p-cresyl sulfate and indoxyl sulfate, during binding with human serum albumin.2013
- Author(s)
  Watanabe H
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 40 Issue: 7 Pages: 1423-8
- DOI
  10.1124/dmd.112.045617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-23790187, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] A human serumalbumin-thioredoxin fusion proteinprevents experimentalcontrast-induced nephropathy2013
- Author(s)
  Kodama A, Watanabe H, Tanaka R, TanakaH, Chuang VTG, Miyamoto Y, Wu Q, EndoM, Hamasaki K, Ishima Y, Fukagawa M, Otagiri M, Maruyama T
- Journal Title
  
  KidneyInt
  
  Volume: 83 Pages: 446-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.2013
- Author(s)
  Tanaka R, Watanabe H, Kodama A, Chuang VT, Ishima Y, Hamasaki K, Tanaka K, Mizushima T, Otagiri M, Maruyama T.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 345 Issue: 2 Pages: 271-283
- DOI
  10.1124/jpet.112.201814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-24790077
[Journal Article] Characterization of hepatic cellular uptake of α1-acid glycoprotein (AGP), part 2: Involvement of hemoglobin β-chain on plasma membranes in the uptake of human AGP by liver parenchymal cells.2012
- Author(s)
  Komori H, Nishi K, Uehara N, Watanabe H, Shuto T, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101 Pages: 1607-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] α(1)-Acid glycoprotein up -regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.2012
- Author(s)
  Komori H, Watanabe H, Shuto T, Kodama A,Maeda H, Watanabe K, Kai H, Otagiri M, Maruyama T.
- Journal Title
  
  J Biol Chem.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] A fourteen-day observation and pharmacokinetic evaluation after a massive intravenous infusion of hemoglobin-vesicles (artificial oxygen carriers) in cynomolgus monkeys.2012
- Author(s)
  Taguchi K, Watanabe H, Sakai H, Horinouchi H, Kobayashi K, Maruyama T, and Otagiri M
- Journal Title
  
  J Drug Metab Toxicol.
  
  Volume: 3 Issue: 4 Pages: 128-34
- DOI
  10.4172/2157-7609.1000128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043
[Journal Article] Elucidation of the therapeutic enhancer mechanism of poly -S-nitrosated human serum albumin against multidrug-resistant tumor in animal models.2012
- Author(s)
  Ishima Y, Hara M, Kragh-Hansen U, Inoue A, Suenaga A, Kai T, Watanabe HOtagiri M, Maruyama T .
- Journal Title
  
  J Control Release.
  
  Volume: 164 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Interaction between twosulfate conjugated uremic toxins,p-cresyl sulfate and indoxyl sulfate,during binding with human serumalbumin2012
- Author(s)
  Watanabe H, Noguchi T, Miyamoto Y,Kadowaki D, Kotani S, Nakajima M,Miyamura S, Ishima Y, Otagiri M,Maruyama T
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 40 Pages: 1423-1428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B.2012
- Author(s)
  Kaneko K, Chuang VT, Ito T, Suenaga A, Watanabe H, Maruyama T, Otagiri M. Pharmazie.
- Journal Title
  
  Pharmazie.
  
  Volume: 67 Pages: 414-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] A uremictoxin,3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage toproximal tubular cells via thegeneration of a radical intermediate2012
- Author(s)
  Miyamoto Y, Iwao Y, Mera K, WatanabeH, Kadowaki D, Ishima Y, Chuang VT,Sato K, Otagiri M, Maruyama T
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 84 Pages: 1207-1214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.2012
- Author(s)
  Miyamoto Y, Iwao Y, Mera K, Watanabe H, Kadowaki D, Ishima Y, Chuang VT, Sato K, Otagiri M, Maruyama T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 84 Pages: 1207-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Characterization of hepatic cellular uptake of α1-acid glycoprotein (AGP), part 2: Involvement of hemoglobin β-chain on plasma membranes in the uptake of human AGP by liver parenchymal cells2012
- Author(s)
  Komori H, Nishi K, Uehara N, Watanabe H, Shuto T, Suenaga A, Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 101 Pages: 1607-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] α1-acid glycoprotein up-regulates CD163 via TLR4/CD14 pathway: possible protection against hemolysis-induced oxidative stress.2012
- Author(s)
  Komori H, Watanabe H, Shuto T, Kodama A, Maeda H, Watanabe K, Kai H, Otagiri M, Maruyama T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Issue: 36 Pages: 30688-700
- DOI
  10.1074/jbc.m112.353771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-23790188, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] Elucidation of the therapeutic enhancer mechanism of poly-S-nitrosated human serum albumin against multidrug-resistant tumor in animal models.2012
- Author(s)
  Ishima Y
- Journal Title
  
  J Control Release.
  
  Volume: 164 Issue: 1 Pages: 1-7
- DOI
  10.1016/j.jconrel.2012.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] Characterization ofhepatic cellular uptake of α1-acidglycoprotein (AGP), part 2:Involvement of hemoglobin β-chain onplasma membranes in the uptake ofhuman AGP by liver parenchymal cells2012
- Author(s)
  Komori H, Nishi K, Uehara N, WatanabeH, Shuto T, Suenaga A, Maruyama T,Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 101 Pages: 1607-1615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Characterization of the hepatic cellular uptake of α(1)-acid glycoprotein (AGP), part 1: A peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells2012
- Author(s)
  Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 101 Pages: 1599-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] α_1-Acid glycoproteinup-regulates CD163 via TLR4/CD14pathway: Possible protection againsthemolysis-induced oxidative stress2012
- Author(s)
  Komori H, Watanabe H, Shuto T, KodamaA, Maeda H, Watanabe K, Kai H, OtagiriM, Maruyama T
- Journal Title
  
  Jbiol Chem
  
  Volume: 31 Pages: 30688-30700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Characterization of the hepaticcellular uptake of α(1) -acidglycoprotein (AGP), part 1: A peptidemoiety of human AGP is recognized bythe hemoglobin β-chain on mouse liverparenchymal cells2012
- Author(s)
  Nishi K, Komori H, Kikuchi M, UeharaN, Fukunaga N, Matsumoto K, WatanabeH, Nakajou K, Misumi S, Suenaga A,Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 101 Pages: 1599-1606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain in A and Ill B.2012
- Author(s)
  Kaneko K, Chuang VT, Ito T, Suenaga A, Watanabe H, Maruyama T, Otagiri M.Pharmazie.
- Journal Title
  
  Pharmazie.
  
  Volume: 67 Pages: 414-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390043
[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
- Author(s)
  Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 101 Issue: 9 Pages: 3222-3229
- DOI
  10.1002/jps.23143
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23651239, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076, KAKENHI-ORGANIZER-20117001
[Journal Article] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.2012
- Author(s)
  Yohei Miyamoto, Yasunori Katsumi Mera, Hiroshi Watanabe, Daisuke Kadowaki, Yu Ishima, Victor Tuan Giam Chuang, Keizo Sato, Masaki Otagiri, Toru Maruyama.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 84 Issue: 9 Pages: 1207-1214
- DOI
  10.1016/j.bcp.2012.07.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J05768, KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23790187, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-24790160
[Journal Article] Characterization of the hepatic cellular uptake of α(1) -acid glycoprotein (AGP), part 1: A peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells.2012
- Author(s)
  Nishi K, Komori H, Kikuchi M, Uehara N, Fukunaga N, Matsumoto K, Watanabe H, Nakajou K, Misumi S, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 101 Pages: 1599-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and FI^*S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 26 Pages: 2498-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury2011
- Author(s)
  Furukawa M, Tanaka R, Chuang VT, Ishima Y, Taguchi K, Watanabe H, Maruyama T, Otagiri M
- Journal Title
  
  J Control Release
  
  Volume: 154 Pages: 189-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial. 15
  
  Pages: 129-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 39
  
  Pages: 484-489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 39 Pages: 484-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M
- Journal Title
  
  Ther Apher Dial
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z, 15Z-bilirubin-LXα revealed by phage display2011
- Author(s)
  Minomo A, Ishima y, Kragh-Hansen U, Chuang VT, Uchida M, Taguchi K, Watanabe H, Maruyama T, Morioka H, Otagiri M
- Journal Title
  
  FEBS J
  
  Volume: 278 Pages: 4100-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialys is patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M,, Tokunaga K,, Komaba H,, Itoh K,, Matsushita K, Watanabe H,, Kadowaki D, Maruyama T,, Otagiri M,, Fukagawa M.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and Fl^* S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human alphal-acid glycoprotein genetic variants, the A and F1*S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Update on the pharmacokinetics and redox properties of protein-bound uremic toxins2011
- Author(s)
  Watanabe H, Miyamoto Y, Otagiri M, Maruyama T
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 3682-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Update on the pharmacokinetics and redox properties of protein-bound uremic toxins.2011
- Author(s)
  Watanabe H, Miyamoto Y, Otagiri M,Maruyama T.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 3682-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Structural insights intodifferences in drug bindingselectivity between two forms of humanalpha1-acid glycoprotein geneticvariants, the A and F1*S forms2011
- Author(s)
  Nishi K, Ono T, Nakamura T, FukunagaN, Izumi M, Watanabe H, Suenaga A,Maruyama T, Yamagata Y, Curry S,Otagiri M
- Journal Title
  
  JBiol Chem
  
  Volume: 286 Pages: 14427-14434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury.2011
- Author(s)
  Furukawa M, Tanaka R, Chuang VT, Ishima Y, Taguchi K, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 154 Pages: 189-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro-and anti-oxidant.2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Fluid resuscitation with hemoglobin-vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther. 337
  
  Pages: 201-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Ther Apher Dial. 15
  
  Pages: 129-131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Characterization of the hepatic cellular uptake of α_1-acid glycoprotein (AGP), Part 1 : A peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells2011
- Author(s)
  西弘二、小森久和
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 101 Issue: 4 Pages: 1599-1606
- DOI
  10.1002/jps.23015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04581, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-23790188, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 26 Pages: 2498-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial. 15
  
  Pages: 161-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011
- Author(s)
  Miyamoto Y,, Watanabe H,, Otagiri M,, Maruyama T.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichiacoli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 39 Pages: 484-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 39 Pages: 484-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2011
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Organic aniontransporters play an important role inthe uptake of p-cresyl sulfate, auremic toxin, in the kidney2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T,Kotani S, Nakajima M, Kadowaki D,Otagiri M, Maruyama T
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 26 Pages: 2498-2502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichiacoli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2011
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci. 100
  
  Pages: 775-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Human serumalbumin-thioredoxin fusion protein with long blood retention property iseffective in suppressing lung injury2011
- Author(s)
  Furukawa M, Tanaka R, Chuang VTG,Ishima Y, Taguchi K, Watanabe H,Maruyama T, Otagiri M
- Journal Title
  
  J Control Release
  
  Volume: 154 Pages: 189-154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z,15Z-bilirubin-IXα revealed by phage display.2011
- Author(s)
  Minomo A, Ishima Y, Kragh-Hansen U, Chuang VT, Uchida M, Taguchi K, Watanabe H, Maruyama T, Morioka H, Otagiri M.
- Journal Title
  
  FEBS J.
  
  Volume: 278 Pages: 4100-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] CYS34 on antioxidativepropertie of HSA quantitativeanalysis of cysteine-34 on theanitioxidative properties of humanserum albumin in hemodialysispatients2011
- Author(s)
  Anraku M, Takeuchi K, Watanabe H,Kadowaki D, Kitamura K, Tomita K,Kuniyasu A, Suenaga A, Maruyama T,Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 3968-3976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790187
[Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 39 Pages: 484-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Repeated injection of high doses of hemoglobin encapsulated liposomes (hemoglobin-vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011
- Author(s)
  Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 39
  
  Pages: 484-489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Characterization of the hepatic cellular uptake of α_1-acid glycoprotein (AGP), Part 2 : Involvement of the hemoglobin β-chain on plasma membranes in the uptake of human AGP by liver parenchymal cells2011
- Author(s)
  小森久和
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 101 Issue: 4 Pages: 1607-1615
- DOI
  10.1002/jps.22804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04581, KAKENHI-PROJECT-21590054, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659076
[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialys is patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin.2011
- Author(s)
  Ishima Y, Yoshida F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, Otagiri M.
- Journal Title
  
  Free Radic Res.
  
  Volume: 45 Pages: 1196-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity2011
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011
- Author(s)
  Ishima Y, Yoshlda F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, Otagiri M
- Journal Title
  
  Free Radic Res
  
  Volume: 45 Pages: 1196-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T
- Journal Title
  
  Ther Apher Dial
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S,Otagiri M
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Pages: 14427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: 26 Pages: 2498-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2011
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci. 100
  
  Pages: 775-783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Fluid resuscitation with hemoglobin vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011
- Author(s)
  Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 161-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients2011
- Author(s)
  Anraku M, Takeuchi K, Watanabe H, Kadowaki D, Kitamura K, Tomita K, Kuniyasu A, Suenaga A, Maruyama T, Otagiri M
- Journal Title
  
  J Pharm Sci
  
  Volume: 100 Pages: 3968-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human{alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.2011
- Author(s)
  Nishi K,, Ono T,, Nakamura T,, Fukunaga N,, Izumi M,, Watanabe H,, Suenaga A,, Maruyama T,, Yamagata Y,, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Structural insights into differences in drug-binding selectivity between two forms of human alphal-acid glycoprotein genetic variants, the A and F1^*S forms2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 14427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
- Journal Title
  
  Nephrol Dial Transplant.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney2011
- Author(s)
  Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T
- Journal Title
  
  Nephrol Dial Transplant
  
  Volume: 26 Pages: 2498-502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki.D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 337 Pages: 201-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human {alpha}1-acid glycoprotein genetic variants, the A and F1^*S forms.2011
- Author(s)
  Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
- Journal Title
  
  J Biol Chem.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients.2011
- Author(s)
  Anraku M, Takeuchi K, Watanabe H, Kadowaki D, Kitamura K, Tomita K, Kuniyasu A, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 3968-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659088
[Journal Article] Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients.2011
- Author(s)
  Anraku M, Takeuchi K, Watanabe H, Kadowaki D, Kitamura K, Tomita K, Kuniyasu A, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011
- Author(s)
  Miyamoto Y, Watanabe H, Otagiri M, Maruyama T.
- Journal Title
  
  Ther Apher Dial.
  
  Volume: 15 Pages: 129-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011
- Author(s)
  Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharmacol Exp Ther. 337
  
  Pages: 201-208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin2011
- Author(s)
  Yu Ishima., et al
- Journal Title
  
  Free Radical Research
  
  Volume: 45 Issue: 10 Pages: 1196-1206
- DOI
  10.3109/10715762.2011.606814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-21390097, KAKENHI-PROJECT-21591000, KAKENHI-PROJECT-22790162, KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23651239
[Journal Article] Albumin fusion of thioredoxin-the production and evaluation, of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 147 Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2010
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release. 145
  
  Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2816-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Albumin fusion of thioredoxin-the production and evaluation of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VTG, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release. 147
  
  Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett. 584
  
  Pages: 2816-2820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Receptor-mediated uptake of human?acid glycoprotein into liver parenchymal cells in mice.2010
- Author(s)
  Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet. 25
  
  Pages: 101-107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties.2010
- Author(s)
  Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 200-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett. 584
  
  Pages: 2816-2820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties.2010
- Author(s)
  Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 200-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2010
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 248 Pages: 234-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Pharmacol. 248
  
  Pages: 234241-234241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2010
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horiuouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2816-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 145 Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Construction of an expression system for human?acid glycoprotein in E.coli : the role of oligosaccharide moieties on structural and functional properties.2010
- Author(s)
  Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet. 25
  
  Pages: 200-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 145 Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 38 Pages: 2124-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties.2010
- Author(s)
  Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 200-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice.2010
- Author(s)
  Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 101-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2816-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Albumin fusion of thioredoxin--the production and evaluation of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 147 Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Phamnacol.
  
  Volume: 248 Pages: 234-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 38 Pages: 2124-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 38
  
  Pages: 2124-2129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Receptor-mediated uptake of human alphal-acid glycoprotein into liver parenchymal cells in mice.2010
- Author(s)
  Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 101-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release. 145
  
  Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 38
  
  Pages: 2124-2129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 145 Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Albumin fusion of thioredoxin-the production and evaluation of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 147 Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Albumin fusion of thioredoxin-the production and evaluation of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 147 Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Pharmacol. 248
  
  Pages: 234-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010
- Author(s)
  Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
- Journal Title
  
  J Control Release.
  
  Volume: 145 Pages: 9-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 38 Pages: 2124-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice.2010
- Author(s)
  Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 101-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties.2010
- Author(s)
  Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 200-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659042
[Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice.2010
- Author(s)
  Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 25 Pages: 101-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2010
- Author(s)
  Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 100 Pages: 775-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Hepatically-metabolize and -excreted artificial oxygen carrier hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 248 Pages: 234-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010
- Author(s)
  Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2816-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
- Author(s)
  Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 248 Pages: 234-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390177
[Journal Article] Albumin fusion of thioredoxin-the production and evaluation of its biological activity for potential therapeutic applications.2010
- Author(s)
  Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
- Journal Title
  
  J Control Release. 147
  
  Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790152
[Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 38 Pages: 2124-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin-vesicles as an artificial oxygen carrier.2009
- Author(s)
  Taguchi K, Urata Y, Anraku M, Maruyama T, Watanabe H, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Kai T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 37
  
  Pages: 1456-1463
- NAID
  130004639499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha (1)-acid glycoprotein.2009
- Author(s)
  Nishi K, Ueno M, Murakami Y, Fukunaga N, Akuta T, Kadowaki D, Watanabe H, Suenaga A, Maruyama T, Otagiri M.
- Journal Title
  
  J Pharm Sci. 98
  
  Pages: 4316-4326
- NAID
  130005024241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells2009
- Author(s)
  Hirayama C, Watanabe H, Nakashima R, Nanbu T, Hamada A, Kuniyasu A, Nakayama H, Kawaguchi T, Saito H.
- Journal Title
  
  Pharm Res. 25
  
  Pages: 827-835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390158
[Journal Article] Hemoglobin vesicles, polyethylene glycol (PEG) ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice.2009
- Author(s)
  Taguchi K, Urata Y, Anraku M, Watanabe H, Kadowaki D, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Maruyama T, Otagiri M.
- Journal Title
  
  Drug Metab Dispos. 37
  
  Pages: 2197-2203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390161
[Journal Article] Role of P-glycoprotein in accumulation and cytotoxicity of amrubicin and amrubicinol in MDR1 gene-transfected LLC-PK1 cells and human A549 lung adenocarcinoma cells2008
- Author(s)
  Hira A, Watanabe H, Maeda Y, Yokoo K, Sanematsu E, Fujii J, Sasaki JI, Hamada A, Saito H.
- Journal Title
  
  Biochem Pharmacol 75
  
  Pages: 973-980
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390158
[Journal Article] Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure2007
- Author(s)
  Iwata K, Matsuzaki T, Watanabe H, Morisaki T, Ohmura T, Hamada A, SaitoH.
- Journal Title
  
  Pharm Res. 24
  
  Pages: 662-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390158
[Journal Article] Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure.2007
- Author(s)
  Matsuzaki T, Watanabe H, Yoshitome K, et al.
- Journal Title
  
  Kidney Int. (印刷中)
- Data Source
  KAKENHI-PROJECT-18790124
[Journal Article] Downregulation of organic anion transporters in rat kidney under ischemialreperfusion-induced acute renal failure.2007
- Author(s)
  Matsuzaki T, Watanabe H, Yoshitome K, Morisaki T, Hamada A, Nonoguchi H, Kohda Y, Tomita K, Inui K, Saito H.
- Journal Title
  
  Kidney Int. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-Induced Acute Renal Failure.2007
- Author(s)
  Iwata K, Watanabe H, Morisaki T, et al.
- Journal Title
  
  Pharm.Res. (印刷中)
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-Induced Acute Renal Failure.2007
- Author(s)
  Iwata K, Watanabe H, Morisaki T, et al.
- Journal Title
  
  Pharm. Res. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-Induced Acute Renal Failure.2007
- Author(s)
  Iwata K, Watanabe H, Morisaki T, Matsuzaki Ohmura T, Hamada A, Saito H.
- Journal Title
  
  Pharm Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure.2007
- Author(s)
  Matsuzaki T, Watanabe H, Yoshitome K, et al.
- Journal Title
  
  Kidney Int. (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Downregulation of organic anion transporters in rat kidney under ischemia/reperfusion-induced acute renal failure2007
- Author(s)
  Matsuzaki T, Watanabe H, Yoshitome K, Morisaki T, Hamada A, Nonoguchi H, Kohda Y, Tomita K, Inui K, Saito H
- Journal Title
  
  Kidney Int. 71
  
  Pages: 539-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390158
[Journal Article] Involvement of Indoxyl Sulfate in Renal and Central Nervous System Toxicities During Cisplatin-Induced Acute Renal Failure.2007
- Author(s)
  Iwata K, Watanabe H, Morisaki T, et al.
- Journal Title
  
  Pharm. Res. (印刷中)
- Data Source
  KAKENHI-PROJECT-18790124
[Journal Article] Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer.2006
- Author(s)
  Yokoo K, Watanabe H, Hamada A, et al.
- Journal Title
  
  Clin. Pharmacol. Ther. 80 (4)
  
  Pages: 422-424
- Data Source
  KAKENHI-PROJECT-18790124
[Journal Article] Chain Length-dependent Binding of Fatty Acid Anions to Human Serum Albumin Studied by Site-directed Mutagenesis.2006
- Author(s)
  Kragh-Hansen U, Watanabe H, Nakajou K, Iwao Y, Otagiri M.
- Journal Title
  
  J Mol Biol. 363(3)
  
  Pages: 702-712
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Chain Length-dependent Binding of Fatty Acid Anions to Human Serum Albumin Studied by Site-directed Mutagenesis.2006
- Author(s)
  Kragh-Hansen U, Watanabe H, Nakajou K, et al.
- Journal Title
  
  J. Mol. Biol. 363(3)
  
  Pages: 702-712
- Data Source
  KAKENHI-PROJECT-18790124
[Journal Article] Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer.2006
- Author(s)
  Yokoo K, Watanabe H, Hamada A, et al.
- Journal Title
  
  Clin.Pharmacol.Ther. 80 (4)
  
  Pages: 422-424
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer.2006
- Author(s)
  Yokoo K, Watanabe H, Hamada A, Masa K, Saito H, Terazaki H, Sasaki Y.
- Journal Title
  
  Clin Pharmacol Ther. 80(4)
  
  Pages: 422-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Pharmacokinetics of amrubicin and its active metabolite amrubicinol in lung cancer patients.2006
- Author(s)
  Matsunaga Y, Hamada A, Okamoto I, Sasaki J, Moriyama E, Kishi H, Matsumoto M, Hira A, Watanabe H, Saito H.
- Journal Title
  
  Ther Drug Monit. 28(1)
  
  Pages: 76-82
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Effect of S-1 on pharmacokinetics of irinotecan in a patient with colorectal cancer.2006
- Author(s)
  Yokoo K, Watanabe H, Hamada A, et al.
- Journal Title
  
  Clin. Pharmacol. Ther. 80(4)
  
  Pages: 422-424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Chain Length-dependent Binding of Fatty Acid Anions to Human Serum Albumin Studied by Site-directed Mutagenesis.2006
- Author(s)
  Kragh-Hansen U, Watanabe H, Nakajou K, et al.
- Journal Title
  
  J. Mol. Biol. 363(3)
  
  Pages: 702-712
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590131
[Journal Article] Chain Length-dependent Binding of Fatty Acid Anions to Human Serum Albumin Studied by Site-directed Mutagenesis.2006
- Author(s)
  Kragh-Hansen U, Watanabe H, Nakajou K, et al.
- Journal Title
  
  J.Mol.Biol. 363(3)
  
  Pages: 702-712
- Data Source
  KAKENHI-PROJECT-17590131
[Patent] 効率的な抗原の細胞内送達とアジュバント活性を有する化合物を有効成分とする薬剤2020
- Inventor(s)
  丸山徹、渡邊博志、前田仁志、一水翔太
- Industrial Property Rights Holder
  丸山徹、渡邊博志、前田仁志、一水翔太
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H03406
[Patent] α１－酸性糖タンパク質の血中濃度上昇をメカニズムとした慢性腎臓病治療薬2017
- Inventor(s)
  丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
- Industrial Property Rights Holder
  丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15320
[Patent] α１－酸性糖タンパク質の血中濃度上昇をメカニズムとした慢性腎臓病治療薬2017
- Inventor(s)
  丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
- Industrial Property Rights Holder
  丸山徹、渡邊博志、異島優、藤村留依、小田切優樹
- Industrial Property Rights Type
  特許
- Filing Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05114
[Patent] α１－酸性糖タンパク質の血中濃度の上昇をメカニズムとした慢性腎臓病治療薬2017
- Inventor(s)
  丸山徹、渡邊博志、異島優、藤村留衣、小田切優樹
- Industrial Property Rights Holder
  丸山徹、渡邊博志、異島優、藤村留衣、小田切優樹
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K15320
[Patent] 細胞膜透過性を有する製剤、細胞膜透過性組成物及び薬物輸送方法2012
- Inventor(s)
  渡邊博志
- Industrial Property Rights Holder
  ニプロ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-097762
- Filing Date
  2012-04-23
- Data Source
  KAKENHI-PROJECT-23390142
[Patent] 腎臓集積性を示すペプチド、薬物担体、製剤、医薬組成物2012
- Inventor(s)
  渡邊博志
- Industrial Property Rights Holder
  ニプロ株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-097763
- Filing Date
  2012-04-23
- Data Source
  KAKENHI-PROJECT-23390142
[Patent] 抗癌剤増感剤2011
- Inventor(s)
  小田切優樹、異島優、渡邊博志、丸山徹
- Industrial Property Rights Holder
  ニプロ株式会社
- Filing Date
  2011-08-12
- Data Source
  KAKENHI-PROJECT-21390177
[Patent] S-ニトロソ化α1-酸性糖タンパク質を含有する抗菌剤2011
- Inventor(s)
  渡辺佳織、異島優、末永綾香、渡邊博志、甲斐俊哉、丸山徹、小田切優樹
- Industrial Property Rights Holder
  ニプロ株式会社
- Filing Date
  2011-07-02
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] アルブミンの基礎から臨床応用へ：アルブミンを基盤とする新たな診断法の構築と次世代型DDS製剤による治療戦略2023
- Author(s)
  渡邊博志
- Organizer
  第1回アルブミン研究討論会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 急性相反応物質α1-酸性糖タンパク質による脂質代謝と不安様行動との関係2023
- Author(s)
  中村侑加、渡邊博志、佐藤崇雄、我那覇悠人、湯本奈緒、松浦叶子、丸山徹
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] NAFLD病態進展におけるα1-酸性糖蛋白質の関与と分子機構解明2023
- Author(s)
  西野入彩乃、渡邊博志、前田仁志、丸山徹
- Organizer
  第40回日本薬学会九州山口支部大会（第一薬科大学）
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] CKD誘発脂肪萎縮における酸化損傷蛋白質 AOPPsの関与2023
- Author(s)
  中野武大、渡邊博志、有村菜々華、加藤大雅、今福匡司、田中元子、松下和孝、前田仁志、丸山徹
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] The pathophysiological role of α1-acid glycoprotein (AGP) in LPS-induced sepsis2023
- Author(s)
  Nao Yumoto, Hiroshi Watanabe, Shunsuke Kamei, Takashi Minami, Hitoshi Maeda, Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2023
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] The uremic toxin indoxyl sulfate contributes to renal fibrosis via mTORC1 signaling pathway2023
- Author(s)
  Takehiro Nakano, Hiroshi Watanabe, Toru Maruyama
- Organizer
  ASN Kidney Week 2023
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 肥満病態進展における急性相反応物質α1-酸性糖タンパク質の関与2023
- Author(s)
  西野入彩乃、渡邊博志、前田仁志、丸山徹
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] 糖・脂質代謝異常における急性相反応物質α1-酸性糖タンパク質の関与2023
- Author(s)
  西野入彩乃、渡邊博志、前田仁志、丸山徹
- Organizer
  第2回ダウン症基礎研究会熊本大会
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] Omega 3 fatty acids attenuated AKI to CKD transition and renal fibrosis: Identification of anti-fibrotic metabolites2023
- Author(s)
  Kai Tokumaru, Hiroshi Watanabe, Tadashi Imafuku, Takao Sato, Tomoaki Inazumi, Hitoshi Maeda, Yukihiko Sugimoto and Toru Maruyama
- Organizer
  ASN Kidney Week 2023
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 慢性腎臓病に対するアルブミン融合チオレドキシンの腎保護効果2023
- Author(s)
  岩切瞭太郎、渡邊博志、村田遼太、前田仁志、丸山徹
- Organizer
  第40回日本薬学会九州山口支部大会（第一薬科大学）
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] Utility of AGP KO mice to assess the contribution of AGP in drug pharmacokinetics2023
- Author(s)
  Yuka Nakamura, Hiroshi Watanabe, Issei Fujita, Yuto Ganaha, Hitoshi Maeda, Toru Maruyama
- Organizer
  日本薬物動態学会第38回年会/第23回シトクロムP450国際会議
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] Utility of AGP-KO mice to assess the contribution of AGP in drug pharmacokinetics2023
- Author(s)
  Yuka Nakamura, Hiroshi Watanabe, Issei Fujita, Yuto Ganaha, Hitoshi Maeda, Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2023
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] 糸球体内皮バリア機能に対するα1-酸性糖タンパク質の保護効果2023
- Author(s)
  湯本奈緒、渡邊博志、藤村留衣、前田仁志、丸山徹
- Organizer
  第2回ダウン症基礎研究会熊本大会
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] ω3系脂肪酸によるAKI to CKD抑制効果と脂肪酸活性代謝物の同定2023
- Author(s)
  徳丸碧海、渡邊博志、今福匡司、佐藤崇雄、稲住知明、前田仁志、杉本幸彦、丸山徹
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 腎病態を制御するアルブミン融合蛋白質の創製2022
- Author(s)
  渡邊博志
- Organizer
  第3回超分子薬剤学FGシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] 透析患者における酸化ストレスの評価: 酸化型アルブミンの臨床的意義2022
- Author(s)
  渡邊博志
- Organizer
  日本透析医学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 蛋白質過酸化物AOPPsによるCKD誘発サルコペニアの分子機構解析2022
- Author(s)
  有村菜々華、渡邊博志、加藤大雅、田中元子、松下和孝、前田仁志、丸山徹
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 尿毒素インドキシル硫酸によるmTORC1を介した腎線維化作用2022
- Author(s)
  中野武大、渡邊博志、今福匡司、田中元子、松下和孝、深川雅史、前田仁志、丸山徹
- Organizer
  フォーラム2022 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K19340
[Presentation] CKD誘発サルコペニアにおける蛋白質過酸化物の関与とその分子機構解明2022
- Author(s)
  加藤大雅、渡邊博志、有村菜々華、今福匡司、田中元子、松下和孝、前田仁志、丸山徹
- Organizer
  日本薬学会第142年会（名古屋）
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 酸化ストレスが誘発する腎病態生理の分子機構学的解明と新たな診断・治療戦略の構築2022
- Author(s)
  渡邊博志
- Organizer
  日本薬学会第142年会（名古屋）：2022年日本薬学会学術振興賞
- Invited
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 尿毒素インドキシル硫酸によるmTORC1を介した腎線維化作用2022
- Author(s)
  中野武大、渡邊博志、今福匡司、田中元子、松下和孝、深川雅史、前田仁志、丸山徹
- Organizer
  フォーラム2022 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] AKI to CKD transition抑制効果に関与するω3系脂肪酸代謝物の同定2021
- Author(s)
  徳丸碧海、今福匡司、渡邊博志、佐藤崇雄、稲住知明、前田仁志、杉本幸彦、丸山徹
- Organizer
  第57回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] AKI to CKDに対するω3系脂肪酸の有効性と脂肪酸活性代謝物の同定2021
- Author(s)
  徳丸碧海、渡邊博志、今福匡司、佐藤崇雄、稲住知明、前田仁志、杉本幸彦、丸山徹
- Organizer
  第3８回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] インドキシル硫酸はmTORC1シグナルを介して腎線維化に寄与する2021
- Author(s)
  中野武大、渡邊博志、今福匡司、田中元子、松下和孝、深川雅史、前田仁志、丸山徹
- Organizer
  第57回日本腎臓学会総会 
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 急性相反応物質であるalpha-1 酸性糖タンパク質によるアルブミン尿抑制作用2020
- Author(s)
  藤村留衣、渡邊博志、宮原麻衣、前田仁志、深川雅史、丸山徹
- Organizer
  第56回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] インドキシル硫酸が誘発する脂肪組織炎症とその分子機構2020
- Author(s)
  中野武大、渡邊博志、田中翔馬、今福匡司、深川雅史、丸山徹
- Organizer
  第56回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] CKD誘発サルコペニアにおける蛋白質過酸化物AOPPsの関与とその分子機構2020
- Author(s)
  加藤大雅、今福匡司、渡邊博志、田中元子、松下和孝、前田仁志、三和高市、丸山徹
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] インドキシル硫酸はmTORC1シグナルを介して腎線維化に寄与する2020
- Author(s)
  中野武大、渡邊博志、今福匡司、田中元子、松下和孝、深川雅史、前田仁志、丸山徹
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] ω3系脂肪酸によるAKI to CKD transition抑制効果2020
- Author(s)
  徳丸碧海,今福匡司,渡邊博志,佐藤崇雄,前田仁志,杉本幸彦,丸山徹
- Organizer
  第56回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] タンパク質過酸化物による腎組織中脂肪酸変動と尿細管障害の分子機構2020
- Author(s)
  徳丸碧海、今福匡司、渡邊博志、佐藤崇雄、松坂賢、稲住知明、田中元子、松下和孝、杉本幸彦、前田仁志、丸山徹
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20H03406
[Presentation] 尿毒症物質が誘発する脂肪組織炎症の分子機構と治療戦略2019
- Author(s)
  田中翔馬、渡邊博志、今福匡司、榎木裕紀、前田仁志、丸山徹
- Organizer
  第43回西日本薬剤学研究会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] CKD誘発骨格筋萎縮における蛋白質過酸化物AOPPsの役割2019
- Author(s)
  渡邊博志、加藤大雅、今福匡司、田中元子、松下和孝、丸山徹
- Organizer
  Reasearch PlaNet 2019
- Invited
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Alpha-1 acid glycoprotein ameliorates hemolysis-induced renal oxidative stress via accelerating plasma free hemoglobin clearance through CD163 induction2019
- Author(s)
  Rui Fujimura, Hiroshi Watanabe, Kento Nishida, Jing Bi, Toru Maruyama
- Organizer
  ASN kidney week2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] CKD誘発筋萎縮病態における蛋白質過酸化物AOPPsの関与2019
- Author(s)
  加藤大雅、渡邊博志、今福匡司、田中元子、松下和孝、丸山徹
- Organizer
  第62回日本腎臓学会学術総会2019
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 副甲状腺ホルモンによる肝臓及び小腸CYP3A発現抑制は腎移植患者における初回タクロリムス投与量の規定因子となる2019
- Author(s)
  渡邊博志、平田憲史郎、杉本龍星、池上孝明、前田仁志、陣上祥子、深川雅史、丸山徹
- Organizer
  第2回日本Uremic Toxin研究会学術集会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 合成レチノイン酸タミバロテンによる腎線維化抑制作用2019
- Author(s)
  中村遼太、Bi Jing、渡邊博志、今福匡司、藤村留衣、大城俊、西田健人、丸山徹
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 酸化修飾アルブミンが誘発する腎組織中脂肪酸組成の変動と尿細管障害の分子機構2019
- Author(s)
  今福匡司、渡邊博志、佐藤崇雄、田中元子、松下和孝、深川雅史、丸山徹
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 腎虚血再灌流障害における急性相反応物質α1-酸性糖蛋白質の病態生理学的役割に関する検討2019
- Author(s)
  平元勇斗、渡邊博志、西田健人、ビージュン、藤村留衣、前田仁志、椋木歩、竹尾透、中潟直己、深川雅史、丸山徹
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Co-treatment of EPR enhancer increases the anti-tumor effect of nab-paclitaxel against pancreatic cancer；EPR増強剤の併用は膵臓癌に対するnab-パクリタキセルの治療効果を増強する2019
- Author(s)
  丸山徹、木下遼、前田仁志、渡邊博志、小田切優樹、異島優
- Organizer
  第30回　日本消化器癌発生学会総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] 副甲状腺ホルモン関連蛋白質は癌病態においてCYP3A発現を抑制する2019
- Author(s)
  松坂幸太朗、藤田一星、渡邊博志、杉本龍星、池上孝明、前田仁志、丸山徹
- Organizer
  第4回日本臨床薬理学会九州・沖縄地方会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Long-acting thioredoxin prevents AKI to CKD transition via its anti-oxidative and anti-inflammatory action2019
- Author(s)
  Hiroshi Watanabe, Kento Nishida, Rui Fujimura, Toru Maruyama
- Organizer
  ASN kidney week2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 尿毒症物質により誘発される脂肪組織炎症-腎障害連関の分子機構解明2019
- Author(s)
  田中翔馬、渡邊博志、今福匡司、榎木裕紀、前田仁志、丸山徹
- Organizer
  第36回日本薬学会九州支部大会2019
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] CKDとサルコペニア～要因、分子機構、治療介入～2019
- Author(s)
  渡邊博志
- Organizer
  第13回日本腎臓病薬物療法学会学術集会・総会2019
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 酸化ストレスが誘発する腎組織中脂肪酸の質的変動と腎病態との関連2019
- Author(s)
  今福匡司、渡邊博志、佐藤崇雄、田中元子、松下和孝、丸山徹
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 腎組織の脂肪酸代謝異常を基軸とした新規腎病態形成機序の解明2018
- Author(s)
  今福匡司、渡邊博志、佐藤祟雄、田中元子、松下和孝、深川雅史、丸山徹
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 副甲状腺ホルモンによる肝臓及び小腸CYP3A発現抑制の分子機構解明と腎移植患者におけるタクロリムス血中濃度との関連2018
- Author(s)
  池上孝明、渡邊博志、杉本龍星、前田仁志、丸山徹
- Organizer
  九重セミナー第42回西日本薬剤学研究会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] クラッシュ症候群誘発急性腎障害に対する一酸化炭素デリバリーの有用性評価2018
- Author(s)
  永崎　太清、柳澤　洋輝、大柿　滋、渡邊　博志、深川　雅史、丸山　徹
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] 腎線維化病態に対するバイオミメティックな一酸化窒素デリバリーシステムの有用性評価2018
- Author(s)
  大城俊、異島優、渡邊博志、前田仁志、深川雅史、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] Parathyroid hormone-related protein secreted from cancer tissues contributes to the down-regulation of CYP3A2018
- Author(s)
  Ikegami K, Watanabe H, Sugimoto R, Maeda H, Maruyama T
- Organizer
  日本薬物動態学会第33回年会／MDO国際合同学会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Albumin based nitric oxide delivery system ameliorates the kidney fibrosis in unilateral ureteral obstruction-treated mice2018
- Author(s)
  Shun Oshiro, Yu Ishima, Hitoshi Maeda, Hiroshi Watanabe , Masaki Otagiri, Toru Maruyama
- Organizer
  米国薬学会 American Association of Pharmaceutical Scientists (AAPS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] 脂質クオリティに着目した腎不全病態の新規メカニズム2018
- Author(s)
  今福匡司、渡邊博志、佐藤崇雄、鬼木健太郎、猿渡淳二、田中元子、松下和孝、深川雅史、丸山徹
- Organizer
  第30回腎と脂質研究会
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 肝腎および腸腎連関における副甲状腺ホルモンの関与と腎外クリアランス変動の分子機構2018
- Author(s)
  渡邊博志、杉本龍星、池上孝明、平田憲史郎、陣上祥子、田中元子、深川雅史、丸山徹
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 急性腎障害に対する一酸化炭素デリバリーシステムの有用性評価2018
- Author(s)
  永崎　太清、柳澤　洋輝、田口　和明、西田　健人、前田　仁志、酒井　宏水、渡邊　博志、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第25回日本血液代替物学会
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] バイオミメティックな一酸化炭素デリバリーは脂肪肝の再生不全を改善する2018
- Author(s)
  和田　直樹、柳澤　洋輝、田口　和明、前田　仁志、木下　学、酒井　宏水、渡邊　博志、小田切　優樹、丸山　徹
- Organizer
  第25回日本血液代替物学会
- Data Source
  KAKENHI-PROJECT-18H02604
[Presentation] 腎組織中脂肪酸の質的変動から見出した新規腎障害メカニズム2018
- Author(s)
  今福匡司、渡邊博志、佐藤崇雄、田中元子、松下和孝、丸山徹
- Organizer
  第17回次世代を担う若手ファーマ・バイオフォーラム2018
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] In silico解析へ向けたα1-酸性糖タンパク質異型間の薬物結合選択性に寄与するアミノ酸残基の同定2018
- Author(s)
  中村侑加、渡邊博志、中村照也、池鯉鮒麻美、石躍華奈、前田仁志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 副甲状腺ホルモンはcAMP/PI3K/PKC/PKA/NF-κBシグナル経路を介してシトクロームP450 3Aの発現低下に寄与する2017
- Author(s)
  池上孝明、渡邊博志、杉本龍星、平田憲史郎、陣上祥子、田中元子、深川雅史、小田切優樹、丸山徹
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 脂質クオリティに着目した腎不全病態の新規メカニズム2017
- Author(s)
  今福匡司、渡邊博志、佐藤崇雄、鬼木健太郎、猿渡淳二、田中元子、松下和孝、深川雅史、丸山徹
- Organizer
  第8回腎不全研究会
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 副甲状腺ホルモンによるABCG2の発現抑制を介した尿酸蓄積機構2017
- Author(s)
  渡邊博志、杉本龍星、池上孝明、田中元子、深川雅史、小田切優樹、丸山徹
- Organizer
  日本薬剤学会　第32回年会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Systemic effects of long-acting albumin-thioredoxin fusion protein against distant organ injury following AKI2017
- Author(s)
  Nishida Kento, Watanabe Hiroshi, Fukagawa Masafumi, Maruyama Toru
- Organizer
  米国腎臓学会議 Kidney Week-ASN 2017
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 持続型BMP7誘導体の肝線維化モデルに対する有用性評価2017
- Author(s)
  高野芽依、渡邊博志、前田仁志、小田切優樹、丸山徹
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 腎機能低下に伴う薬物動態の臨床的意義～副甲状腺ホルモンによる新たな制御機構～2017
- Author(s)
  渡邊博志、田中元子、深川雅史、丸山徹
- Organizer
  医療薬学フォーラム2017　第25回クリニカルファーマシーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through cAMP/PI3K/Akt signaling pathway in secondary hyperparathyroidism2017
- Author(s)
  Hiroshi Watanabe, Ryusei Sugimoto, Masafumi Fukagawa and Toru Maruyama
- Organizer
  Kidney Week-ASN 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 副甲状腺ホルモンはcAMP/PI3K/PKC/PKA/NF-κBシグナル経路を介してシトクロームP450 3Aの発現低下に寄与する2017
- Author(s)
  池上孝明、渡邊博志、杉本龍星、平田憲史郎、陣上祥子、田中元子、深川雅史、小田切優樹、丸山徹
- Organizer
  日本薬物動態学会第32回年会
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 慢性腎臓病が誘発する骨格筋萎縮における尿毒素の関与とその分子機構（口頭発表）2017
- Author(s)
  丸山　徹、渡邊　博志、榎木　裕紀、荒毛　里歩、田中　元子、松下　和孝、深川　雅史
- Organizer
  第1回日本Uremic Toxin研究会学術集会
- Place of Presentation
  東京：ベルサール八重洲
- Year and Date
  2017-02-18
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 尿毒素誘発骨格筋萎縮の分子機構を基盤した既存薬による治療戦略（口頭発表）2017
- Author(s)
  渡邊博志、榎木裕紀、田中元子、松下和孝、駒場大峰、深川雅史、丸山徹
- Organizer
  第1回日本CKD-MBD研究会学術集会・総会
- Place of Presentation
  東京：コクヨホール
- Year and Date
  2017-03-04
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 慢性腎臓病が誘発する骨格筋萎縮における尿毒素の関与とその分子機構（口頭発表）*最優秀演題賞2016
- Author(s)
  渡邊博志、榎木裕紀、荒毛里歩、田中元子、松下和孝、深川雅史、丸山徹
- Organizer
  第3回日本サルコペニア・フレイル研究会研究発表会
- Place of Presentation
  名古屋：今池ガスビル
- Year and Date
  2016-11-06
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 腎線維化マウスに対するビタミンD受容体活性化剤とビタミンA誘導体の治療効果（口頭発表）2016
- Author(s)
  Bi Jing、西田健人、藤村留衣、今福匡司、富永結菜、渡邊博志、小田切優樹、丸山徹
- Organizer
  第31回日本薬物動態学会
- Place of Presentation
  長野：キッセイ文化ホール　松本市総合体育館
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] CKD誘発骨格筋紹介に対するAST-120の有効性評価（口頭発表）2016
- Author(s)
  荒毛　里歩、榎木　裕紀、渡邊　博志、異島　優、田中　元子、松下　和孝、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  神奈川 : パシフィコ横浜、会議センター
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 新規酸化ストレス早期発見に向けた血清パースルフィド定量の有用性評価（口頭発表）2016
- Author(s)
  池田真由美、異島優、渡邊博志、石田竜弘、小田切優樹、丸山徹
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋市立大学大学院薬学研究科・薬学部
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Molecular mechanism of uremic toxin induced-skeletal muscle atrophy in chronic kidney disease（ポスター発表）2016
- Author(s)
  Hiroshi Watanabe, Yuki Enoki, Riho Arake, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa and Toru Maruyama
- Organizer
  The 2nd Asian Conference for Frailty and Sarcopenia (ACFS)
- Place of Presentation
  名古屋：今池ガスビル
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Long-acting albumin-thioredoxin fusion protein prevents AKI-associated acute lung injury2016
- Author(s)
  Kento Nishida, Hiroshi Watanabe, Masafumi Fukagawa and Toru Maruyama
- Organizer
  Kidney Week-ASN 2016
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] S-Nitrosated human serum albumin dimer as a novel nano EPR enhancer applied to nanotechnology based anticancer drugs2016
- Author(s)
  Ryo Kinoshita , Yu Ishima, Mayumi Ikeda, Jun Fang, Hiroshi Maeda,Masaki Otagiri, Toru Maruyama
- Organizer
  2016 Controlled Release Society Annual Meeting & Exposition
- Place of Presentation
  Washington State Convention Center,USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] 質量分析によるアルブミンの翻訳後修飾解析を基軸とした糖尿病患者の酸化ストレス評価（ポスター発表）2016
- Author(s)
  今福匡司、宮村重幸、異島優、渡邊博志、吉田陽、陣内秀昭、丸山徹
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Downregulation of ABCG2, a Urate Exporter, by Parathyroid Hormone Enhances Urate Accumulation in Secondary Hyperparathyroidism2016
- Author(s)
  Hiroshi Watanabe, Ryusei Sugimoto, Motoko Tanaka, Hirotaka Komaba, Masafumi Fukagawa and Toru Maruyama
- Organizer
  第49回米国腎臓学会議 Kidney Week-ASN 2016
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] Molecular mechanism of uremic toxin induced-skeletal muscle atrophy in chronic kidney disease2016
- Author(s)
  Hiroshi Watanabe, Yuki Enoki, Riho Arake, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa and Toru Maruyama
- Organizer
  The 2nd Asian Conference for Frailty and Sarcopenia
- Place of Presentation
  Japan, Nagoya
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] Design and evaluation of long-acting thioredoxin by using albumin fusion technology as a superior therapeutic agent for acute kidney injury (口頭発表、シンポジウム)2016
- Author(s)
  Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
- Organizer
  第1回日韓若手薬剤学研究者ワークショップ(The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics )
- Place of Presentation
  京都：京都教育文化センター
- Year and Date
  2016-06-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 副甲状腺ホルモンは尿酸排泄トランスポーターの発現抑制を介して尿酸の蓄積を促進する（口頭発表）2016
- Author(s)
  杉本　龍星、渡邊　博志、異島　優、田中　元子、松下　和孝、駒場　大峰、深川　雅史、丸山　徹
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  神奈川 : パシフィコ横浜、会議センター
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] Renoprotective Effect of Long Acting Thioredoxin by Modulating Oxidative Stress and Macrophage Migration Inhibitory Factor Against Rhabdomyolysis associated Acute Kidney Injury（ポスター）2016
- Author(s)
  Kento Nishida, Hiroshi Watanabe, Tadashi Imafuku, Yu Ishima, Masaki Otagiri, Toru Maruyama
- Organizer
  第1回日韓若手薬剤学研究者ワークショップ(The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics )
- Place of Presentation
  京都：京都教育文化センター
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 慢性腎臓病における腎-多臓器連関に関わる尿毒素の関与とその分子機構2016
- Author(s)
  渡邊博志、異島優、小田切優樹、丸山徹
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Downregulation of ABCG2, a Urate Exporter, by Parathyroid Hormone Enhances Urate Accumulation in Secondary Hyperparathyroidism2016
- Author(s)
  Hiroshi Watanabe, Ryusei Sugimoto, Motoko Tanaka, Hirotaka Komaba, Masafumi Fukagawa and Toru Maruyama
- Organizer
  Kidney Week-ASN 2016
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] Long-acting albumin-thioredoxin fusion protein prevents AKI-associated acute lung injury（ポスター発表）2016
- Author(s)
  Kento Nishida, Hiroshi Watanabe, Masafumi Fukagawa and Toru Maruyama
- Organizer
  第49回米国腎臓学会議 Kidney Week-ASN
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] AKI誘発急性肺障害モデルにおける血中滞留型チオレドキシンの有効性評価（口頭発表）2016
- Author(s)
  西田　健人、宮久　優子、渡邊　博志、異島　優、小田切　優樹、深川　雅史、丸山　徹
- Organizer
  第7回腎不全研究会
- Place of Presentation
  東京：全社協・灘尾ホール
- Year and Date
  2016-12-10
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 腎線維化マウスに対するビタミンD受容体活性化剤とビタミンA誘導体の治療効果 (口頭発表) *優秀演題賞2016
- Author(s)
  Bi Jing、西田健人、藤村留衣、今福匡司、富永結菜、渡邊博志、小田切優樹、丸山徹
- Organizer
  第23回日本血液代替物学会年次大会
- Place of Presentation
  早稲田大学・西早稲田キャンパス55号館
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] Molecular mechanism of uremic toxin induced-skeletal muscle atrophy in chronic kidney disease2016
- Author(s)
  Hiroshi Watanabe, Yuki Enoki, Riho Arake, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa and Toru Maruyama
- Organizer
  The 2nd Asian Conference for Frailty and Sarcopenia
- Place of Presentation
  Japan, Nagoya
- Year and Date
  2016-11-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] Long-acting albumin-thioredoxin fusion protein ameliorates acute kidney injury and its associated acute lung injury*The APSTJ Global Education Seminar Presentation Award 20162016
- Author(s)
  Kento Nishida, Hiroshi Watanabe, Masako Miyahisa, Yu Ishima, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
- Organizer
  The APSTJ Global Education Seminar
- Place of Presentation
  長崎大学薬学部
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] 腎糸球体への移行性を有するα 1-酸性糖蛋白質は糸球体バリア保持機能と抗炎症作用により慢性腎不全を改善する（ポスター発表）2016
- Author(s)
  藤村留衣、西田健人、渡邊博志、小田切　優樹、丸山徹
- Organizer
  第31回日本薬物動態学会
- Place of Presentation
  長野：キッセイ文化ホール　松本市総合体育館
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] S-Nitrosated human serum albumin dimer as a novel nano EPR enhancer applied to nanotechnology based anticancer drug2016
- Author(s)
  Ryo Kinoshita (D2), Yu Ishima, Mayumi Ikeda, Jun Fang, Hiroshi Maeda,Masaki Otagiri, Toru Maruyama
- Organizer
  2016 Controlled Release Society Annual Meeting & Exposition
- Place of Presentation
  Washington State Convention Center,USA
- Year and Date
  2016-07-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 急性相蛋白質であるα1-酸性糖蛋白質は抗炎症性作用によりアドリアマイシン腎症を改善する（口頭発表）2016
- Author(s)
  藤村　留衣、西田　健人、渡邊　博志、異島　優、小田切　優樹、丸山　徹
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜、会議センター
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K15320
[Presentation] Long-acting albumin-thioredoxin fusion protein prevents AKI-associated acute lung injury2016
- Author(s)
  Kento Nishida, Hiroshi Watanabe, Masafumi Fukagawa and Toru Maruyama
- Organizer
  第49回米国腎臓学会議 Kidney Week-ASN 2016
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] Downregulation of ABCG2, a Urate Exporter, by Parathyroid Hormone Enhances Urate Accumulation in Secondary Hyperparathyroidism（ポスター発表）2016
- Author(s)
  Hiroshi Watanabe, Ryusei Sugimoto, Motoko Tanaka, Hirotaka Komaba, Masafumi Fukagawa and Toru Maruyama
- Organizer
  第49回米国腎臓学会議 Kidney Week-ASN
- Place of Presentation
  USA：Chicago McCormick Place
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 慢性腎臓病が誘発する骨格筋萎縮に対するAST-120の有効性評価2016
- Author(s)
  渡邊　博志、榎木　裕紀、荒毛　里歩、田中　元子、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第31回日本薬物動態学会
- Place of Presentation
  長野：キッセイ文化ホール　松本市総合体育館
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H05114
[Presentation] 慢性腎臓病における定量的酸化ストレス評価法の確立とそれを基盤とした治療戦略2015
- Author(s)
  渡邊博志、田中元子、深川雅史、小田切優樹、丸山徹
- Organizer
  第32回和漢医薬学会学術大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2015-08-21
- Invited
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdommyolysis-associated acute kidney injury2015
- Author(s)
  Hiroshi Watanabe, Kento Nishida, Masafumi Fukagawa, Toru Maruyama
- Organizer
  第48回米国腎臓学会議
- Place of Presentation
  USA：San Diego Convention Center
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 新規ナノEPR増強剤である一酸化窒素付加アルブミンダイマーを用いた高分子抗癌剤治療の効率化2015
- Author(s)
  木下遼、異島優、池田真由美、方軍、前田浩、渡邊博志、小田切優樹、丸山徹
- Organizer
  第22回日本血液代替物学会年次大会
- Place of Presentation
  熊本：熊本大学薬学部
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] 遺伝子工学的手法を用いた血中滞留型BMP7の設計と持続的腎保護作用の評価2015
- Author(s)
  戸田翔太、渡邊博志、異島優、小田切優樹、丸山徹
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  愛知：名古屋国際会議場
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] Poly-S-二トロソ化ヒト血清アルブミンのHIF-1alpha抑制効果2015
- Author(s)
  異島優、井上亜希、小田切優樹、渡邊博志、丸山徹
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京：京王プラザホテル
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] 腎指向型アルブミン-BMP7ハイブリット体の創製と腎保護効果の検討2015
- Author(s)
  戸田翔太、渡邊博志、弥永直樹、濱崎慶輔、國安明彦、長谷川功紀、後藤久美子、異島優、小田切優樹、丸山徹
- Organizer
  第32回日本薬学会九州支部大会
- Place of Presentation
  宮崎：九州保健福祉大学
- Year and Date
  2015-11-28
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] Anti-tumor effect of Poly-S-nitrosated Human Serum Albumin is enhanced by phosphodiesterase 5 inhibitors2015
- Author(s)
  Mayumi Ikeda, Yu Ishima, Ryo Kinoshita, Hiroshi Watanabe, Tsuyoshi Ikeda, Masaki Otagiri, Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2015
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2015-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to nano-anticancer drugs2015
- Author(s)
  Ryo Kinoshita, Yu Ishima, Mayumi Ikeda, Jun Fang, Hiroshi Maeda, Masaki Otagiri, Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2015
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2015-11-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] 急性及び慢性肝炎モデルマウスにおけるCD68+/CD206+クッパ―細胞由来活性酸素種を標的としたナノ抗酸化アルブミンの治療効果2015
- Author(s)
  前田仁志、一水翔太、渡邊博志、異島優、小田切優樹、丸山徹
- Organizer
  第31回日本DDS学会学術集
- Place of Presentation
  東京：京王プラザホテル
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K15185
[Presentation] アルブミン融合技術を利用した血中滞留型チオレドキシンの創製と難治性肺疾患治療への応用2015
- Author(s)
  渡邊博志、田中遼大、異島優、Chuang VTG、小田切優樹、丸山徹
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会合同大会ワークショップ
- Place of Presentation
  兵庫：神戸ポートアイランド
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 市販のアルブミン製剤に対する機能と翻訳後修飾の関連性2015
- Author(s)
  今福匡司、宮村重幸、安楽誠、山崎啓之、富永結菜、異島優、渡邊博志、小田切優樹、丸山徹
- Organizer
  第30回日本薬物動態学会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] アルブミン融合技術を利用した血中滞留型BMP7の作製と腎線維化抑制作用2015
- Author(s)
  渡邊博志、戸田翔太、異島優、小田切優樹、丸山徹
- Organizer
  第30回日本薬物動態学会
- Place of Presentation
  東京：タワーホール船堀
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15H04758
[Presentation] 新規尿毒症物質ニトロ化インドキシル硫酸の活性酸素誘導能2014
- Author(s)
  丸山　徹、成底　徹、渡邊　博志、小田切　優樹、深川　雅史、異島　優
- Organizer
  第5回腎不全研究会
- Place of Presentation
  東京：全社協・灘尾ホール
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] ヒト血清アルブミンにおけるCys34-Cysteinylationの機序解明-肝硬変の影響-2014
- Author(s)
  南雲恒平（D3）、今福匡司、山田尚之、渡邊博志、異島優、田中基彦、佐々木裕、小田切優樹、丸山徹
- Organizer
  日本薬学会第134年会2014/3/27-30（熊本）
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] ESI-TOFMSを用いた透析患者由来ヒト血清アルブミンの翻訳後修飾解析2014
- Author(s)
  宮村重幸（D3社会人）、南雲恒平、杉森剛志、渡邊博志、山田尚之、小田切優樹、丸山徹
- Organizer
  日本薬学会第134年会2014/3/27-30（熊本）
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 尿毒症物質パラクレジル硫酸によるNADPH oxidase活性化を介した尿細管及び血管障害作用2014
- Author(s)
  渡邊　博志、宮本　洋平、異島　優、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第26回腎とフリーラジカル研究会
- Place of Presentation
  産業労働センターウインクあいち
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate2014
- Author(s)
  Hiroshi Watanabe, Yoshiaki Sakaguchi, Ryusei Sugimoto, Yu Ishima, Ken-ichi Kaneko, Hiroshi Iwata, Masaki Otagiri and Toru Maruyama
- Organizer
  8th International Society on Uremia Research and Toxicity
- Place of Presentation
  Okinawa convention hall
- Invited
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 尿毒症物質p-クレジル硫酸の酸化ストレス誘導を介した尿細管障害作用2013
- Author(s)
  渡邊博志、宮本洋平、田中寿絵、異島優、田中元子、松下和孝、深川雅史、小田切優樹、丸山徹
- Organizer
  第58回日本透析医学会学術集会総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] アルブミン-チオレドキシン融合蛋白質はヨード造影剤腎症の発症を予防する2013
- Author(s)
  渡邊博志
- Organizer
  第56回　日本腎臓学会学術総会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression2013
- Author(s)
  Ryota Tanaka, Hiroshi Watanabe, Yu Ishima, Masaki Otagiri, Toru Maruyama
- Organizer
  The 5th Asian Arden conference
- Place of Presentation
  Aichi Gakuin University
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 遺伝子組換え型糖鎖付加アルブミンによるクッパー細胞選択的チオール送達は急性肝障害を改善する2013
- Author(s)
  前田仁志, 平田憲史郎, 渡邊博志, 異島優, 末永綾香, 小田切優樹, 丸山徹
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 尿毒症物質インドキシル硫酸の生物活性に及ぼす活性酸化窒素種の影響2013
- Author(s)
  成底徹, 異島優, 小谷俊介, 中島誠, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  第13回日本NO学会学術集会
- Place of Presentation
  沖縄県医師会館
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] MECHANISM OF ENHANCED CYSTEINYLATION OF Cys34 IN HUMAN SERUM ALBUMIN IN CHRONIC LIVER DISEASE2013
- Author(s)
  Kohei Nagumo（D3）, Tsuyosi Sugimori, Naoyuki Yamada, Hiroshi Watanabe, Yu Ishima, Motohiko Tanaka, Yutaka Sasaki, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 高分子抗癌剤の腫瘍集積性を高めるS-ニトロソ化アルブミンダイマーのEPR効果増強作用2013
- Author(s)
  異島優, 方軍, 前田浩, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  第13回日本NO学会学術集会
- Place of Presentation
  沖縄県医師会館
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 尿毒素の酸化ストレス誘導を介したマウス骨格筋細胞障害作用2013
- Author(s)
  榎木裕紀（D2）、渡邊博志、異島優、小田切優樹、丸山徹
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎国際大学
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 尿毒症物質p-クレジル硫酸の腎排泄過程におけるhOATsの関与2013
- Author(s)
  坂口義明（B6）、渡邊博志、宮本洋平、異島優、金子健一、岩田宏、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] ESI-TOF MSを用いた透析患者由来ヒト血清アルブミンの翻訳後修飾解析2013
- Author(s)
  南雲恒平（D3）、杉森剛志、阿部貴弥、申曽洙、渡邊博志、山田尚之、田中元子、松下和孝、小田切優樹、丸山徹
- Organizer
  第58回日本透析医学会学術集会総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Therapeutic impact of human serum albumin-thioredoxin fusion protein, long-acting anti-oxidative and anti-inflammatory modulator, against acetaminophen-induced acute liver failure2013
- Author(s)
  Ryota Tanaka, Hitoshi Maeda, Azusa Kodama, Hiroshi Watanabe, Yu Ishima, Toru Maruyama and Masaki Otagiri
- Organizer
  Asian Federation for Pharmaceutical Sciences 2013
- Place of Presentation
  Ramada Plaza Jeju Hotel
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy2013
- Author(s)
  Azusa Kodama, Hiroshi Watanabe, Ryota Tanaka, Hisae Tanaka, Victor Tuan Giam Chuang, Yohei Miyamoto, Yu Ishima, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
- Organizer
  The 5th Asian Arden conference
- Place of Presentation
  Aichi Gakuin University
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] ヒト有機アニオントランスポーターは尿毒症物質p-クレジル硫酸の高容量性トランスポーターとして機能する（2013
- Author(s)
  杉本龍星（D1）、渡邊博志、坂口義明、宮本洋平、異島優、金子健一、岩田宏、小田切優樹、丸山徹
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎国際大学
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Mechanism of enhanced cysteinylation of Cys34 in human serum albumin in chronic liver disease2013
- Author(s)
  Kohei Nagumo (D3), Tadashi Imafuku, Naoyuki Yamada, Hiroshi Watanabe, Yu Ishima, Motohiko Tanaka, Yutaka Sasaki, Masaki Otagiri and Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2013
- Place of Presentation
  Ramada Plaza Jeju Hotel
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] TRANSPORT OF P-CRESYL SULFATE, A UREMIC TOXIN, VIA HUMAN ORGANIC ANION TRANSPORTER2013
- Author(s)
  Hiroshi Watanabe, Yoshiaki Sakaguchi, Ryusei Sugimoto, Yu Ishima, Ken-ichi Kaneko, Hiroshi Iwata, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Kupffer cell selective delivery of thiols by genetically engineered mannosylated-albumin as a new therapeutic strategy for hepatitis2013
- Author(s)
  Hitoshi Maeda, Hiroshi Watanabe, Yu Ishima, Masaki Otagiri, Toru Maruyama
- Organizer
  The 5th Asian Arden conference
- Place of Presentation
  Aichi Gakuin University
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] アルブミン-チオレドキシン融合蛋白質はヨード造影剤腎症の発症を予防する2013
- Author(s)
  渡邊博志, 小玉あずさ, 田中遼大, 田中寿絵, 異島優, 深川雅史, 小田切優樹, 丸山徹
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知, ウインクあいち
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy2013
- Author(s)
  Hiroshi Watanabe, Azusa Kodama, Ryota Tanaka, Hisae Tanaka, Victor Tuan Giam Chuang, Yu Ishima, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama
- Organizer
  Asian Federation for Pharmaceutical Sciences 2013
- Place of Presentation
  Ramada Plaza Jeju Hotel
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] アルブミン-チオレドキシン融合体によるシスプラチン腎症予防効果2013
- Author(s)
  小玉あずさ, 田中遼大, 渡邊博志, 異島優, 深川雅史, 小田切優樹, 丸徹日
- Organizer
  本薬剤学会第28年会
- Place of Presentation
  愛知, ウインクあいち
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] アルブミンーチオレドキシン誘導体による薬剤性急性腎障害の発症予防と機序解明2013
- Author(s)
  小玉あずさ, 渡邊博志, 田中遼大, 田中寿絵, 異島優, 深川雅史, 小田切優樹, 丸山徹
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学本郷キャンパス
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 高分子抗癌剤の腫瘍集積性を高めるS-ニトロソ化アルブミンダイマーのEPR効果増強作用2013
- Author(s)
  異島優, 方軍, 前田浩, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知, ウインクあいち
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] Poly-S-nitrosated Human Serum Albumin inhibits the Expression of P-glycoprotein Transporter in Human Multidrug-resistant Tumor2013
- Author(s)
  Yu Ishima, Marie Hara, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
- Organizer
  The 5th Asian Arden conference
- Place of Presentation
  Aichi Gakuin University
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 骨髄標的化エリスロポエチンの製剤設計と腎性貧血治療への応用2013
- Author(s)
  丸山徹, 宮崎裕理, 田口和明, 渡邊博志, 宗慶太郎, 田中元子, 松下和孝, 深川雅史, 小田切優樹
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知, ウインクあいち
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] クッパー細胞選択的チオール送達によるアセトアミノフェン肝障害治療法の開発2013
- Author(s)
  前田仁志, 平田憲史郎 , 渡邊博志, 異島優, 末永綾香, 小田切優樹, 丸山徹
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知, ウインクあいち
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] S-ニトロソ化アルブミンダイマーはEPR 効果を増強する2012
- Author(s)
  井上亜希, 異島優, 方軍, 前田浩, 小田切優樹, 渡邊博志, 丸山徹
- Organizer
  日本薬剤学会第27年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 尿毒症物質p-クレジル硫酸のレドックス特性と腎障害、心血管疾患発症機序解明2012
- Author(s)
  宮本洋平、渡邊博志、本田大輔、門脇大介、異島優、深川雅史、小田切優樹、丸山徹
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate accumulates in proximal tubular cells and induces cell damage through increasing oxidative stress2012
- Author(s)
  Yohei Miyamoto, Yasunori Iwao, Katsumi Mera, Hiroshi Watanabe, Daisuke Kadowaki, Yu Ishima, Victor Tuan Giam Chuang, Keizo Sato, Masaki Otagiri and Toru Maruyama
- Organizer
  49th ERA-EDTA Congress, Paris 2012
- Place of Presentation
  Paris（フランス）
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] p-Cresyl sulfate causesrenal tubular cell damage by inducingoxidative stress through theactivation of NADPH oxidase2012
- Author(s)
  Hiroshi Watanabe, Daisuke Honda,Yohei Miyamoto, Tsuyoshi Noguchi,Daisuke Kadowaki, Yu Ishima, MotokoTanaka, Hisae Tanaka, MasafumiFukagawa, Masaki Otagiri and Toru Maruyama
- Organizer
  49th ERA-EDTA Congress, Paris 2012
- Place of Presentation
  Paris (France)
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] p -Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress through the activation of NADPH oxidase2012
- Author(s)
  Hiroshi Watanabe
- Organizer
  49th ERA-EDTA Congress, Paris 2012
- Place of Presentation
  Paris(France)
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] 尿毒症物質 p-クレジル硫酸は OATsを介して近位尿細管上皮、血管内皮及び血管平滑筋細胞に取り込まれ酸化ストレス障害を誘発する2012
- Author(s)
  渡邊博志,宮本洋平,本田大輔,田中寿絵,深川雅史,異島優,小田切優樹,丸山徹
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀(千葉)
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質（AGP）の抗菌機能獲得と感染症治療への応用2012
- Author(s)
  渡辺佳織
- Organizer
  第12回日本NO学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] S・ニトロソ化に伴うα1・酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用(第34回生体膜と薬物の相互作用シンポジウム2012
- Author(s)
  渡辺佳織
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部(京都府)
- Data Source
  KAKENHI-PROJECT-24390043
[Presentation] 急性腎障害に対するアルブミン-チオレドキシン融合体の治療効果と機序解明2012
- Author(s)
  小玉　あずさ、田中　遼大、渡邊　博志、田中　寿絵、異島　優、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第29回　日本薬学会九州支部大会
- Place of Presentation
  熊本大学薬学部
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 尿毒症物質p-クレジル硫酸はOATsを介して近位尿細管上皮、血管内皮及び血管平滑筋細胞に取り込まれ酸化ストレス障害を誘発する2012
- Author(s)
  渡邊博志
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] 尿毒症物質, p-クレジル硫酸の酸化ストレス誘導を介した腎障害作用2012
- Author(s)
  渡邊博志, 本田大輔, 宮本洋平, 野口剛,門脇大介,異島優,小谷俊介,中島誠,深川雅史,小田切優樹,丸山徹
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  北海道大学 (北海道)
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 尿毒症物質p-クレジル硫酸はOATsを介して近位尿細管上皮、血管内皮及び血管平滑筋細胞に取り込まれ酸化ストレス障害を誘発する2012
- Author(s)
  渡邊博志、宮本洋平、本田大輔、田中寿絵、深川雅史、異島優、小田切優樹、丸山徹
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress through the activation of NADPH oxidase2012
- Author(s)
  Hiroshi Watanabe
- Organizer
  49th ERA-EDTA Congress
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] p-Cresyl sulfate causes renal tubular cell damage by kmiducing oxidative stress through the activation of NADPH oxidase.2012
- Author(s)
  Watanabe H
- Organizer
  49th ERA-EDTA Congress, Paris 2012.
- Place of Presentation
  Paris (France)
- Data Source
  KAKENHI-PROJECT-24390043
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質（AGP）の抗菌機能獲得と感染症治療への応用　(第34回生体膜と薬物の相互作用シンポジウム2012
- Author(s)
  渡辺佳織
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部（京都府）
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果と機序解明2012
- Author(s)
  異島優, 原茉梨絵, 末永綾香, 甲斐俊哉, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress through the activation of NADPH oxidase.2012
- Author(s)
  Watanabe H
- Organizer
  49th ERA-EDTA Congress, Paris 2012.
- Place of Presentation
  Paris（France）
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質（AGP）の抗菌機能獲得と感染症治療への応用2012
- Author(s)
  渡辺佳織
- Organizer
  第12回日本NO学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] ヒト血清アルブミン－チオレドキシン融合タンパク質は抗酸化作用によりシスプラチン誘発腎障害を抑制する2012
- Author(s)
  小玉　あずさ, 田中　遼大, 渡邊　博志, 異島　優, 小田切　優樹, 丸山　徹
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用2012
- Author(s)
  渡辺佳織
- Organizer
  第12回日本NO学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress through the activation of NADPH oxidase2012
- Author(s)
  Hiroshi Watanabe, Daisuke Honda, Yohei Miyamoto, Tsuyoshi Noguchi, Daisuke Kadowaki, Yu Ishima, Motoko Tanaka, Hisae Tanaka, Masafumi Fukagawa, Masaki Otagiri and Toru Maruyama
- Organizer
  49th ERA-EDTA Congress, Paris 2012
- Place of Presentation
  Paris（フランス）
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] A uremictoxin, CMPF accumulates in proximaltubular cells and induces cell damagethrough increasing oxidative stress2012
- Author(s)
  Yohei Miyamoto, Yasunori Iwao,Katsumi Mera, Hiroshi Watanabe,Daisuke Kadowaki, Yu Ishima1, VictorTuan Giam Chuang, Keizo Sato, MasakiOtagiri and Toru Maruyama
- Organizer
  49th ERA-EDTA Congress, Paris 2012
- Place of Presentation
  Paris (France)
- Year and Date
  2012-05-24
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用2012
- Author(s)
  渡辺佳織
- Organizer
  第12回日本NO学会学術集会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-24390043
[Presentation] S-ニトロソ化に伴うα1-酸性糖タンパク質(AGP)の抗菌機能獲得と感染症治療への応用2012
- Author(s)
  渡辺佳織
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学薬学部
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] 尿毒症物質 p-クレジル硫酸のレドックス特性と腎障害、心血管疾患発症機序解明2012
- Author(s)
  宮本洋平,渡邊博志,本田大輔,門脇大介,異島優,深川雅史,小田切優樹,丸山徹
- Organizer
  第34回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学(京都)
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] ブレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価2011
- Author(s)
  田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡, グランシップ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響2011
- Author(s)
  本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果2011
- Author(s)
  渡邊博志、丸山徹、小田切優樹, 他
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響2011
- Author(s)
  本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] MS解析を用いた慢性肝炎時におけるヒト血清アルブミンのレドックス解析と構造及び機能との関連性2011
- Author(s)
  南雲恒平、杉森剛志、窪田和幸、山田尚之、異島優、渡邊博志、田申基彦、佐々木裕、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] MS解析を用いた慢性肝炎時におけるヒト血清アルブミンのレドックス解析と構造及び機能との関連性2011
- Author(s)
  南雲恒平、杉森剛志、窪田和幸、山田尚之、異島優、渡邊博志、田中基彦、佐々木裕、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果2011
- Author(s)
  大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡,グランシップ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions2011
- Author(s)
  Yohei Miyamoto, Yasunori Iwao, YukaTasaki, Keizo Sato, Yu Ishima, HiroshiWatanabe, Daisuke Kadowaki, ToruMaruyama and Masaki Otagiri
- Organizer
  4^th Asia Pacific ISSX Meeting 2011
- Place of Presentation
  Tainan (Taiwan)
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] Interaction between p-cresyl sulfate and indoxyl sulfate during body disposition can influence their serum free concentrations in chronic kidney disease2011
- Author(s)
  Watanabe H, Otagiri M, et al.
- Organizer
  Asian Federation for Pharmaceutical Sciences 2011
- Place of Presentation
  Malaysia, Kuala Lumpur
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] 尿毒症物質p-クレジル硫酸が慢性腎臓病の酸化ストレスに及ぼす影響2011
- Author(s)
  本田大輔, 宮本洋平, 渡邊博志, 門脇大介, 小田切優樹, 丸山徹
- Organizer
  日本薬剤学会 26年会
- Place of Presentation
  タワーホール船堀(千葉)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム2011
- Author(s)
  宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] プレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価2011
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 抗酸化作用に対するオルメサルタンとアゼルニジピンの併用効果2011
- Author(s)
  末永綾香、麻生美紗子、宮本洋平、門脇大介、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Interaction betweenp-cresol sulfate and indoxyl sulfateduring body disposition can influencetheir serum free concntrations inchronic kidney disease2011
- Author(s)
  Watanabe H, Miyamoto Y, Noguchi T,Suenaga A, Kadowaki D, Otagiri M,Maruyama T
- Organizer
  AsianFederation For PharmaceuticalSciences Conference
- Place of Presentation
  KualaLumpur (Malaysia)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果2011
- Author(s)
  大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] MS解析を用いた慢性肝炎時におけるヒト血清アルブミンのレドックス解析と構造及び機能との関連性2011
- Author(s)
  南雲恒平, 杉森剛志, 窪田和幸, 山田尚之, 異島優, 渡邊博志, 田中基彦, 佐々木裕, 小田切優樹, 丸山徹
- Organizer
  日本薬学会大131年会
- Place of Presentation
  静岡, グランシップ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 112位と114位のアミノ酸残基はα1・酸性糖タンパク質バリアント間の薬物結合選択機構に寄与する2011
- Author(s)
  丸山徹、和泉実代子、中村照也、西弘二、小野知実、渡邊博志、山縣ゆり子、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果2011
- Author(s)
  大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響2011
- Author(s)
  本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Interaction between p-cresyl sulfate and indoxyl sulfate during body disposition can influence their serum free concentrations in chronic kidney disease2011
- Author(s)
  Hiroshi Watanabe, Masaki Otagiri, et al
- Organizer
  Asian Federation for Pharmaceutical Sciences 2011
- Place of Presentation
  Malaysia, Kuala Lumpur
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] CMPF causes renal cell damage viaoxidative stress induction2011
- Author(s)
  Yohei Miyamoto, Yasunori Iwao,Katsumi Mera, Hiroshi Watanabe,Daisuke Kadowaki Keizo Sato, MasakiOtagiri, Toru Maruyama, Uremic toxin
- Organizer
  7th International Congress on UremiaResearch and Toxicity 2011
- Place of Presentation
  Nagoya Congress Center (Nagoya)
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 尿毒症物質 p-クレジル硫酸とインドキシル硫酸との相互作用の動態学的機序解明2011
- Author(s)
  野口剛,宮本洋平,渡邊博志,小田切優樹,丸山徹
- Organizer
  日本薬剤学会 26 年会
- Place of Presentation
  タワーホール船堀(千葉)
- Year and Date
  2011-05-29
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 抗酸化作用に対するオルメサルタンとアゼルニジピンの併用効果2011
- Author(s)
  末永綾香、麻生美紗子、宮本洋平、門脇大介、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム2011
- Author(s)
  宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果2011
- Author(s)
  大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡,グランシップ
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Poly-SNO-アルブミンによる抗癌剤耐性克服効果2011
- Author(s)
  渡邊博志、原茉梨絵、異島優、末永綾香、丸山徹、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響2011
- Author(s)
  本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 112位と114位のアミノ酸残基はα1-酸性糖タンパク質バリアント間の薬物結合選択機構に寄与する2011
- Author(s)
  丸山徹、和泉実代子、中村照也、西弘二、小野知実、渡邊博志、山縣ゆり子、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム2011
- Author(s)
  宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Acute-phase protein alpha1-acid glycoprotein acquires anti-bacterial activity through S-nitrosylation by a nitric oxide-dependent mechanism2011
- Author(s)
  Kaori Watanabe, Masaki Otagiri, et al.
- Organizer
  4th Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan. Taiwan
- Data Source
  KAKENHI-PROJECT-23659088
[Presentation] プレオマイシン誘発肺線維症に対するアルブミン-チオレドキシン融合体の有用性評価2011
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 臓器移植保存液としてのS-ニトロソ化アルブミンの有用性評価2011
- Author(s)
  品川拓也, 異島優, 米重梓二, 末永綾香, 渡邊博志, 丸山徹, 小田切優樹
- Organizer
  第18回日本血液代替物学会年次大会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23390142
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム2011
- Author(s)
  宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  ツインメッセ静岡
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] 尿毒症物質はインドキシル硫酸の生合成を促進する2011
- Author(s)
  村田道哉,児玉彬,渡邊博志,異島優,小田切優樹,丸山徹
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡大学薬学部(福岡)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 尿毒症物質はインドキシル硫酸の生合成を促進する2011
- Author(s)
  村田　道哉、児玉　彬、渡邊　博志、異島　優、小田切　優樹、丸山　徹
- Organizer
  第28回日本薬学会九州支部大会
- Place of Presentation
  福岡大学
- Data Source
  KAKENHI-PROJECT-23790187
[Presentation] 出血性ショックモデルラットにおけるヘモグロビン小胞体頻回投与時での体内動態について2011
- Author(s)
  田口和明、渡邊博志、酒井宏水、丸山徹、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 出血性ショックモデルラットにおけるヘモグロビン小胞体頻回投与時での体内動態について2011
- Author(s)
  田口和明、渡邊博志、酒井宏水、丸山徹、小田切優樹
- Organizer
  日本薬学会年会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Acute-phase protein alphal-acid glycoprotein acquires anti-bacterial activity through S-nitrosylation by a nitric oxide-dependent mechanism2011
- Author(s)
  Kaori Watanabe, Masaki Otagiri, et al
- Organizer
  4th Asia Pacific Regional ISSX Meeting
- Place of Presentation
  Tainan. Taiwan
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE2010
- Author(s)
  Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] S-ニトロソアルブミンによる細胞内NO輸送におけるNO修飾率の影響2010
- Author(s)
  渡邊博志
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] S-ニトロソ化α_1-酸性糖タンパク質の抗菌活性評価2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] α1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE2010
- Author(s)
  Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 尿毒症物質CMPFの生体内レドックス特性2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  京都,烟川
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Hepatic uptake of alfal-acid glycoprotein through hemoglobin beta-chain-mediated endocytic pathway2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  9^<th> International ISSX meeting
- Place of Presentation
  Istanbul
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] 一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 尿毒症物質CMPFの生体内レドックス特性2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  京都, 烟川
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発機序解明2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] チオレドキシンとアルブミン融合体の作製と生物活性の評価2010
- Author(s)
  小田切優樹, 生田祥太郎、Tuan Giam Chung Victor, 異島優, 中城圭介, 古川真斗, 渡邊博志, 丸山徹
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] alfa1-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  九重共同研修所
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 肝疾患時におけるアルブミンの構造及び機能評価2010
- Author(s)
  南雲恒平, 杉森剛志, 田中基彦, 佐々木裕, 異島優, 渡邊博志, 窪田和幸, 山田尚之, 小田切優樹, 丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 尿毒症物質CMPFの生体内レドックス特性2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 丸山徹尿毒症物質CMPFの酸化ストレス誘発機序解明2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球の肝チトクロームP450保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] PROTECTIVE EFFECT OF S-NITROSYLATED HUMAN SERUM ALBUMINS TO ORGAN INJURY2010
- Author(s)
  Shinji Yoneshige, Yu Ishima, Ayaka Suenaga, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Involvement of hemoglobin b-chain on plasma membrane in uptake of human al-acid glycoprotein into liver2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  The Pharmaceutical Sciences World Congress 2010
- Place of Presentation
  New Orleans, LA, USA
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価2010
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] S-ニトロソ化α_1-酸性糖タンパク質の抗菌活性評価2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] alfa1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] α1-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS2010
- Author(s)
  田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] ヒトα_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島郷土文化会館
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  第26回日本薬学会九州支部大会
- Place of Presentation
  長崎大学
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] Involvement of hemoglobin・chain on plasma membrane in uptake of human・1-acid glycoprotein into liver2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  The Pharmaceutical Sciences World Congress 2010
- Place of Presentation
  Morial Convention Center, New Orleans,USA
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 一酸化炭素結合型赤血球による肝チトクロームP450の保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Involvement of hemoglobin b-chain on plasma membrane in uptake of human a1-acid glycoprotein into liver2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  The Phannaceutical Sciences World Congress 2010
- Place of Presentation
  New Orleans Morial Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  第26回日本薬学会九州支部大会
- Place of Presentation
  長崎大学
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] ヘモグロビン小胞体の体内動態と慢性肝障害の関係に関する検討2010
- Author(s)
  田口和明, 宮里麻友美, 渡邊博志, 土田英俊, 小林紘一, 丸山徹, 小田切優樹
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010
- Author(s)
  Miyoko Izumi., Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Effect OF combination treatment of Azelnidipine on Antioxidative activity of Ol mesaltan In human vascular endothelial cells2010
- Author(s)
  Misako Aso, Yohei Miyamoto, Daisuke Kadowaki, Hiroshi Watanabe, Ayaka Suenaga, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] S-ニトロソアルブミンによる細胞内NO輸送におけるNO修飾率の影響2010
- Author(s)
  渡邊博志
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発機序解明2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] alfa1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] チオレドキシンとアルブミン融合体の作製と生物活性の評価2010
- Author(s)
  小田切優樹, 生田祥太郎, Tuan Giam Chung Victor, 異島優, 中城圭介, 古川真斗, 渡邊博志, 丸山徹
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] S-ニトロソアルブミンによる細胞内NO輸送におけるNO修飾率の影響2010
- Author(s)
  渡邊博志
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010
- Author(s)
  Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] α1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] PROTECTIVE EFFECT OF S-NITROSYLATED HUMAN SERUM ALBUMINS TO ORGAN INJURY2010
- Author(s)
  Shinji Yoneshige, Yu Ishima, Ayaka Suenaga, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS2010
- Author(s)
  田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE2010
- Author(s)
  Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOP ROTEIN AND DRUG COMPLEX2010
- Author(s)
  Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 臓器障害に対する各種SNO-HSAの保護効果2010
- Author(s)
  米重梓二、異島優、末永綾香、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] α_1-酸性糖タンパク質はS-ニトロソ化により抗菌活性を獲得する2010
- Author(s)
  渡辺佳織, 異島優, 末永綾香, 渡邊博志, 甲斐俊哉, 丸山徹, 小田切優樹
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] ヘモグロビン小胞体の出血性ショックモデルラットにおける大腸菌増殖抑制効果2010
- Author(s)
  田口和明、渡邊博志、丸山徹、小田切優樹, 他
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] Hepatic uptake of alfa1-acid glycoprotein through hemoglobin b-chain-mediated endocytic pathway2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  9^<th> International ISSX meeting
- Place of Presentation
  Istanbul, Turkey Convention and Exhibition Center-Harbiye
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] オルメサルタンの抗酸化作用に及ぼすアゼルニジピンの影響2010
- Author(s)
  麻生美紗子、宮本洋平、門脇大介、渡邊博志、末永綾香、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] 尿毒症物質CMPFの酸化ストレス誘発機序解明2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価2010
- Author(s)
  田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価2010
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] Effect OF combination treatment of Azelnidipine on Antioxidative activity of Olmesaltan In human vascular endothelial cells2010
- Author(s)
  Misako Aso, Yohei Miyamoto, Daisuke Kadowaki, Hiroshi Watanabe, Ayaka Suenaga, Masaki Otagiri, Toru Maruyama
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球の肝チトクロームP450保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] ヘモグロビン小胞体の体内動態と慢性肝障害の関係に関する検討2010
- Author(s)
  田口和明, 宮里麻友美, 渡邊博志, 土田英俊, 小林紘一, 丸山徹, 小田切優樹
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] ヒトalfal-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010
- Author(s)
  和泉実代子、小野知実、中村照也、西弘二、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] α1-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] リポソーム型人工酸素運搬体ヘモグロビン小胞体の脂質膜構成成分の安全性に関する検討2010
- Author(s)
  田口和明, 渡邊博志, 酒井宏水, 丸山徹, 小田切優樹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] Hepatic uptake of・1-acid glycoprotein through hemoglobin・-chain-mediated endocytic pathway2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  9^<th> International ISSX meeting
- Place of Presentation
  Istanbul Lutfi Kirdar Convention and Exhibition Center-Harbiye, Istanbul, Turkey
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 一酸化炭素結合型赤血球による肝チトクロームP450の保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第25回日本薬剤学会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 1-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  Komori H, Watanabe H, Syuto T,Maruyama T, Otagiri M
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  大分, 九重共同研修所
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] alfa1-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  九重共同研修所
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] オルメサルタンの抗酸化作用に及ぼすアゼルニジピンの影響2010
- Author(s)
  麻生美紗子、宮本洋平、門脇大介、渡邊博志、末永綾香、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] リポソーム型人工酸素運搬体ヘモグロビン小胞体の脂質膜構成成分の安全性に関する検討2010
- Author(s)
  田口和明, 渡邊博志, 酒井宏水, 丸山徹, 小田切優樹
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球のチトクロームP450の保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本国際交流会館
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Hepatic uptake of alfa1-acid glycoprotein through hemoglobin b-chain-mediated endocytic pathway2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  9^<th> International ISSX meeting
- Place of Presentation
  Istanbul Lutfi Kirdar Convention and Exhibition Center-Harbiye (Turkey)
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球のチトクロームP450の保護効果2010
- Author(s)
  大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本国際交流会館
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価2010
- Author(s)
  田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎大学薬学部
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] 尿毒症物質CMPFの生体内レドックス特性2010
- Author(s)
  宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
- Organizer
  第27回臨床フリーラジカル会議
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  Komori H, Watanabe H, Syuto T, Maruyama T, Otagiri M
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学武田先端知ビル
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010
- Author(s)
  Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] 1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010
- Author(s)
  Komori H, Watanabe H, Syuto T, Maruyama T, Otagiri M
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京大学武田先端知ビル
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] ヘモグロビン小胞体の出血性ショックモデルラットにおける大腸菌増殖抑制効果2010
- Author(s)
  田口和明, 渡邊博志, 酒井宏水, 堀之内宏久, 小林絋一, 丸山徹, 小田切優樹
- Organizer
  第17回日本血液代替物学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] 臓器障害に対する各種SNO-HSAの保護効果2010
- Author(s)
  米重梓二、異島優、末永綾香、渡邊博志、小田切優樹、丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 肝疾患時におけるアルブミンの構造及び機能評価2010
- Author(s)
  南雲恒平, 杉森剛志, 田中基彦, 佐々木裕, 異島優, 渡邊博志, 窪田和幸, 山田尚之, 小田切優樹, 丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS2010
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE2010
- Author(s)
  Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-21790152
[Presentation] ヒトα_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010
- Author(s)
  和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島郷土文化会館
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] Involvement of hemoglobin beta-chain on plasma membrane in uptake of human alfal-acid glycoprotein into liver2010
- Author(s)
  Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
- Organizer
  The Pharmaceutical Sciences World Congress 2010
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010
- Author(s)
  Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 肝疾患時におけるアルブミンの構造及び機能評価2010
- Author(s)
  南雲恒平, 杉森剛志, 田中基彦, 佐々木裕, 異島優, 渡邊博志, 窪田和幸, 山田尚之, 小田切優樹, 丸山徹
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS2010
- Author(s)
  田中遼大、古川真斗、異島優、田中健一郎、水島徹、渡邊博志、小田切優樹、丸山徹
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] ヒトa_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010
- Author(s)
  和泉実代子、小野知実、中村照也、西弘二、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21659042
[Presentation] alfal-酸性糖タンパク質によるCD163の発現誘導2010
- Author(s)
  Komori H, Watanabe H, Syuto T, Maruyama T, Otagiri M
- Organizer
  第35回西日本薬剤学研究会
- Place of Presentation
  大分,九重共同研修所
- Data Source
  KAKENHI-PROJECT-20390161
[Presentation] ヒトa_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010
- Author(s)
  和泉実代子、小野知実、中村照也、西弘二、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21390177
[Presentation] 尿毒症物質インドキシル硫酸の酸化修飾体に関する構造特性と生物活性
- Author(s)
  丸山　徹、異島　優、成底　徹、小谷　俊介、中島　誠、渡邊　博志、小田切　優樹
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] Renal Drug Delivery Systemを可能とする腎標的化ペプチドの網羅的探索
- Author(s)
  戸田　翔太、渡邊　博志、弥永　直樹、濱崎　慶輔、國安　明彦、異島　優、小田切　優樹、丸山　徹
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] アルブミン-チオレドキシン融合体によるシスプラチン腎症予防効果
- Author(s)
  小玉　あずさ、渡邊　博志、田中　遼大、近藤　真澄、WU　Qiong、遠藤　正之、異島　優、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 透析患者における新規酸化ストレスマーカーとしてのシステイン付加Cys34アルブミンの有用性評価
- Author(s)
  今福　匡史、南雲　恒平、杉森　剛志、阿部　貴弥、申　曽洙、渡邊　博志、山田　尚之、田中　元子、松下　和孝、小田切　優樹、丸山　徹
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] OAT-dependent cellular accumulation of p-cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.
- Author(s)
  Hiroshi Watanabe, Yohei Miyamoto, Yuki Enoki, Yu Ishima, Masafumi Fukagawa, Masaki Otagiri and Toru Maruyama
- Organizer
  19th North American ISSX Meeting and 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 尿毒症物質 p‐クレジル硫酸の酸化ストレス誘導を介した血管障害作用
- Author(s)
  渡邊　博志、宮本　洋平、榎木　裕紀、異島　優、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] 酸化ストレス関連疾患とトランスレーショナルリサーチ
- Author(s)
  渡邊　博志、南雲　恒平、田中　遼大、小玉　あずさ、異島　優、山田　尚之、瀬戸山　博子、田中　基彦、佐々木　裕、田中　元子、深川　雅史、小田切　優樹、丸山　徹
- Organizer
  第8回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本大学薬学部
- Year and Date
  2014-11-15 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-25460190
[Presentation] MOLECULAR PHARMACOKINETIC MECHANISMS OF OXIDATIVE STRESS-INDUCED TISSUE DAMAGE IN CHRONIC KIDNEY DISEASE FOR MEDICAL DEVELOPMENT AND THERAPEUTIC APPLICATION
- Author(s)
  Hiroshi Watanabe
- Organizer
  19th North American ISSX Meeting and 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco, California, USA
- Year and Date
  2014-10-19 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460190
[]

1. MARUYAMA Toru (90423657)

# of Collaborated Projects: 17 results

# of Collaborated Products: 412 results
2. OTAGIRI MASAKI (80120145)

# of Collaborated Projects: 10 results

# of Collaborated Products: 276 results
3. ISHIMA Yu (00457590)

# of Collaborated Projects: 3 results

# of Collaborated Products: 49 results
4. 前田仁志 (80791483)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
5. SAITO Hideyuki (40225727)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NONOGUCHI Hiroshi (30218341)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. HAMADA Akinobu (00322313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. MATSUMOTO Mitsuhiro (70253755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 森岡弘志 (20230097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 小谷俊介 (50551280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小橋川敬博 (90455600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 佐藤卓史 (70555755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 亀澤世奈 (21000621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山本卓 (70444156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 後藤祐児 (40153770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 山口圭一 (90432187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. IFUKU Shinsuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. KURAUCHI Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. YAMASAKI Keishi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. ISHITSUKA Youichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. IHARA Hideshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. SARUWATARI Junji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. KAZAMA Junichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. SHUTO Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 斎藤秀之

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
26. 田口和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
27. 杉本幸彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 小森久和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 澤智裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 成田一衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 石田竜弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 安楽誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WATANABE HIROSHI 渡邊 博志

WATANABE Hiroshi 渡邊 博志

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Elucidation of the molecular basis of proteinuria suppression by the acute phase protein orosomucoid and its application to the treatment of chronic kidney diseasePrincipal Investigator

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Elucidation of CKD pathophysiology and development of diagnostic and therapeutic strategies based on comprehensive post-translational modification analysis of albuminPrincipal Investigator

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Treatment strategy based on the pathophysiology of renal-multi-organ axis induced by pathogenic albuminPrincipal Investigator

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Treatment strategy for kidney disease based on TLR4-macrophage control by alfa1-acid glycoproteinPrincipal Investigator

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Strategy for the personalized CKD medicine based on the crosstalk between albumin-bound uremic toxin and kidneyPrincipal Investigator

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WATANABE HIROSHI 渡邊博志

WATANABE Hiroshi 渡邊博志