Hara Hiromichi 原弘道

… Alternative Names

HARA Hiromichi 原弘道

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Researcher Number	70398791
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 東京慈恵会医科大学, 医学部, 教授 2022 – 2023: 東京慈恵会医科大学, 医学部, 教授 2019 – 2021: 東京慈恵会医科大学, 医学部, 准教授 2014 – 2018: 東京慈恵会医科大学, 医学部, 講師 2017: 東京慈恵会医科大学, 医学部, 助教 2013: 東京慈恵会医科大学, 医学部, 助教 2010 – 2011: 東京慈恵会医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine
Keywords	Principal Investigator COPD / cgas-sting / cGAS-STING / ミトコンドリアUPR / IPF / 特発性肺線維症 / PGE-MUM / 間質性肺炎 / ミトコンドリア / マイトファジー … More / ミトコンドリア動態 / CKB / クレアチンキナーゼB(CKB) / オートファジー / 慢性閉塞性肺疾患 … More Except Principal Investigator COPD / 気管支喘息 / 難治性喘息 / フェロトーシス / 小胞体 / 特発性肺線維症 / オートファジー / SASP / Bcl-2 / PDL-1 / MICA / 老化細胞除去 / 線維芽細胞 / 肺線維化 / 細胞老化 / 線維化 / IPF / 肺癌 / PGE-MUM / 肺腺癌 / 尿中PGE-MUM Less

慢性閉塞性肺疾患、特発性肺線維症における老化細胞の違いと病態への関連性の解明Principal Investigator
- Principal Investigator
  
  原弘道
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
COPD病態におけるcGAS-STINGの重要性Principal Investigator
- Principal Investigator
  
  原弘道
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
喫煙による喘息難治化におけるフェロトーシスの役割
- Principal Investigator
  
  宮川英恵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
the role of endoplasmic reticulum selective autophagy in the pathogenesis of idiopathic pulmonary fibrosis
- Principal Investigator
  
  NUMATA Takanori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
mitochondria UPR in Idiopathic interstitial pneumoniaPrincipal Investigator
- Principal Investigator
  
  hara hiromichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Jikei University School of Medicine
Prostaglandin E- major urinary metabolite (PGE-MUM) as a tumor marker for lung adenocarcinoma
- Principal Investigator
  
  UTSUMI HIROFUMI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Role of senescent cell removal mechanism in the pathogenesis of idiopathic pulmonary fibrosis
- Principal Investigator
  
  Haruhiko Yanagisawa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Clinical evaluation of PGE-MUM as a biomarker in IPFPrincipal Investigator
- Principal Investigator
  
  Hara Hiromichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
Role of mitophagy and mitochondrial dynamics in cigarette smoke-induced bronchial epithelial cell senescence.Principal Investigator
- Principal Investigator
  
  HARA Hiromichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine
The role of autophagy in COPD pathogenesisPrincipal Investigator
- Principal Investigator
  
  HARA Hiromichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Jikei University School of Medicine

All 2017 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017
- Author(s)
  Horikiri T, Hara H, Saito N, Araya J, Takasaka N, Utsumi H, Yanagisawa H, Hashimoto M, Yoshii Y, Wakui H, Minagawa S, Ishikawa T, Shimizu K, Numata T, Arihiro S, Kaneko Y, Nakayama K, Matsuura T, Matsuura M, Fujiwara M, Okayasu I, Ito S, Kuwano K.
- Journal Title
  
  Respir Med.
  
  Volume: 122 Pages: 43-50
- DOI
  10.1016/j.rmed.2016.11.017
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09194, KAKENHI-PROJECT-15K09233, KAKENHI-PROJECT-16K09558
[Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.2015
- Author(s)
  Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Autophagy
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860661
[Journal Article] Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.2014
- Author(s)
  Takasaka N, Nakayama K, et al.
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 3 Pages: 958-968
- DOI
  10.4049/jimmunol.1302341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-24591178, KAKENHI-PROJECT-25860660, KAKENHI-PROJECT-25860661
[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.2013
- Author(s)
  Hara H, Araya J, Ito S, Kobayashi K, Takasaka N, Yoshii Y, Wakui H, Kojima J, Shimizu K, Numata T, Kawaishi M, Kamiya N, Odaka M, Morikawa T, Kaneko Y, Nakayama K, Kuwano K.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol.
  
  Volume: 305(10) Issue: 10 Pages: L737-L746
- DOI
  10.1152/ajplung.00146.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591162, KAKENHI-PROJECT-24591139, KAKENHI-PROJECT-25860661
[Journal Article] Involvement of creatin kinase B in cigarette smoke-induced bronchial epithelial cell senescence2012
- Author(s)
  Hiromichi Hara
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46(3) Pages: 306-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790771
[Journal Article]2012
- Author(s)
  Hara H, Araya J, Takasaka N, Fujii S, Kojima J, Yumino Y, Shimizu K, Ishikawa T, Numata T, Kawaishi M, Saito K, Hirano J, Odaka M, Morikawa T, Hano H, Nakayama K, Kuwano K
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 46(3) Pages: 306-312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790771
[Journal Article]2011
- Author(s)
  原弘道, 藤井さと子, 荒屋潤, 皆川俊介, 弓野陽子, 小島淳, 沼田尊功, 河石真, 中山勝敏, 桑野和善
- Journal Title
  
  分子呼吸器病学
  
  Volume: Vol.15, No.1 Pages: 94-96
- Data Source
  KAKENHI-PROJECT-22790771
[Journal Article]
- Author(s)
  Fujii S, Hara H, Araya J, Takasaka N, Kojima J, Ito S, Minagawa S, Yumino Y, Ishikawa T, Numata T, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura S L, Nakayama K, Kuwano K
- Journal Title
  
  Oncoimmunology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790771
[Presentation] Cigarette smoke-induced oxidative modification of CKB is involved in the pathogenesis of COPD in terms of acceleration of bronchial epithelial cell senescence2011
- Author(s)
  H Hara, J Araya, N Takasaka, J Kojima, Y Yumino, S Fujii, T Numata, M Kawaishi, J Hirano, M Odaka, T Morikawa, K Nakayama, and K Kuwano
- Organizer
  European Respiratory Society Annual congress
- Place of Presentation
  Amsterdam
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-22790771
[Presentation] COPDにおける細胞老化とクレアチニンキナーゼに関する検討2011
- Author(s)
  原弘道、荒屋潤、高坂直樹、弓野陽子、藤井さと子、小島淳、石川威夫、沼田尊功、河石真、中山勝敏、桑野和善
- Organizer
  日本呼吸器学学会総会
- Place of Presentation
  東京
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22790771
[Presentation] The Involvement of Autophagy in Cigarette Smoking Extract-induced Cellular Senescence in Human Bronchial Epithelial Cells American2010
- Author(s)
  H Hara, S Nojiri, J Araya, Y Yumino, S Minagawa, J Kojima, T Numata, M Kawaishi, M Odaka, K Nakayama, T Morikawa, K Kuwano
- Organizer
  Thoracic Society International Conference
- Place of Presentation
  New Orleans
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-22790771

1. 荒屋潤 (90468679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. KUWANO KAZUYOSHI (40205266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. UTSUMI HIROFUMI (00773855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Haruhiko Yanagisawa (00773425)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NUMATA Takanori (30366257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮川英恵 (90869413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 皆川俊介 (70468685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 中山勝敏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hara Hiromichi 原 弘道

HARA Hiromichi 原 弘道

Research Projects

Research Products

Co-Researchers

慢性閉塞性肺疾患、特発性肺線維症における老化細胞の違いと病態への関連性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

COPD病態におけるcGAS-STINGの重要性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

喫煙による喘息難治化におけるフェロトーシスの役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

the role of endoplasmic reticulum selective autophagy in the pathogenesis of idiopathic pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

mitochondria UPR in Idiopathic interstitial pneumoniaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prostaglandin E- major urinary metabolite (PGE-MUM) as a tumor marker for lung adenocarcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of senescent cell removal mechanism in the pathogenesis of idiopathic pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical evaluation of PGE-MUM as a biomarker in IPFPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of mitophagy and mitochondrial dynamics in cigarette smoke-induced bronchial epithelial cell senescence.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of autophagy in COPD pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 2. Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.2015

Author(s)

Journal Title

Data Source

[Journal Article] Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence.2013

Hara Hiromichi 原弘道

HARA Hiromichi 原弘道