SEKINE Shuichi 関根秀一

Researcher Number	70401007
Affiliation (based on the past Project Information) *help	2015 – 2018: 千葉大学, 大学院薬学研究院, 講師 2014 – 2015: 千葉大学, 薬学研究科(研究院), 講師 2011 – 2014: 千葉大学, 薬学研究科(研究院), 助教 2012: 千葉大学, 大学院・薬学研究院・, 助教 2007 – 2012: Chiba University, Graduate school of pharmaceutical sciences, Assistant Professor … More 2008: Chiba University, 大学院薬学研究院, 助教 2006: 千葉大学, 大学院薬学研究院, 助手 2005: Chiba University, Graduate School of Pharmaceutical Sciences, Research Associate, 大学院・薬学研究院, 助手 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Physical pharmacy
Keywords	Principal Investigator 胆汁うっ滞 / ミトコンドリア / 薬剤反応性 / 薬学 / トランスポーター / BSEP / 自然免疫 / 肝障害 / 劇症肝炎 / 胆汁鬱滞 … More / 活性代謝物 / 薬物代謝酵素 / 薬剤性肝障害 / 胆汁排泄輸送担体 / 国際情報交換 / 局在変化 / 胆汁酸 / 薬剤反応生 / 放射線 / 蛋白質 / シグナル伝達 / 胆汁排泄輪送体 / 胆汁排泄 / MRP2 / PKC / 膜動輸送 / 胆汁排泄輸送体 / 薬物動態学 … More Except Principal Investigator 肝障害 / HLA / 特異体質毒性 / 薬剤反応性 / MRP2 / 薬物性肝障害 / 国際情報交換 / 薬学 / 獲得免疫 / 自然免疫 / 免疫寛容 / keratinocytes / hepatotoxicity / innate immune response / Toll like receptor / 薬物過敏症 / 副作用個人差 / 皮疹 / Protein / Drug reactivity / Signal transduction / Biophysical / 蛋自質 / 蛋白質 / シグナル伝達 / 生物物理 / nitric oxide / protein kinase C / transporter / biliary excretion / glutathione / cholestasis / oxidative stress / 脂質過酸化 / 化学発光 / 酸化的ストレス / 一酸化窒素 / Protein kinase C / トランスポーター / 胆汁排泄 / グルタチオン / 胆汁うっ滞 / 酸化ストレス / 薬剤性肝障害 / 増悪 / 薬剤反応生 / 代謝学 / 薬物動態 / 臨床 / 放射線 / プロテオーム Less

Construction of an in vivo model for prediction of fulminant type DILI in preclinical/clinicalPrincipal Investigator
- Principal Investigator
  
  関根秀一
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Chiba University
Elucidation of the onset mechanism of abacavir-induced severe skin reaction using humanized model animal
- Principal Investigator
  
  Ito Kousei
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Elucidation of the pathogenesis of idiosyncratic drug-induced liver injury using HLA-transfected mice for establishment of preclinical prediction method
- Principal Investigator
  
  Ito Kousei
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Fundamental study for integrated understanding of the mechanism of DILI and its predictionPrincipal Investigator
- Principal Investigator
  
  Sekine Shuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Basis study for the prediction of fatal DILI risk based on MHC expression in the liver
- Principal Investigator
  
  Ito Kousei
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicity
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
The role of phosphorylation status of radixin on the localization of billiary transportersPrincipal Investigator
- Principal Investigator
  
  SEKINE Shuichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Molecular analysis of localization of biliary transporters in chronic hepatitis
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
Detection of BSEP mediated hepatotoxicity by using the intrahepatic bile acid imaging techniquePrincipal Investigator
- Principal Investigator
  
  SEKINE Shuichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Molecular analysis and biological effect of PKC isoforms dependent membrane trafficking of Mrp2/BsepPrincipal Investigator
- Principal Investigator
  
  SEKINE Shuichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Chiba University
Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox status
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University
MRP2 mediated defense against oxidative stress in liver
- Principal Investigator
  
  HORIE Toshiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Chiba University

[Journal Article] Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat2018
- Author(s)
  Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Kousei Ito
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 5 Pages: 339-351
- DOI
  10.2131/jts.43.339
- NAID
  130006733279
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06744
[Journal Article] Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice2017
- Author(s)
  Susukida Takeshi、Aoki Shigeki、Kogo Kotaro、Fujimori Sota、Song Binbin、Liu Cong、Sekine Shuichi、Ito Kousei
- Journal Title
  
  Archives of Toxicology
  
  Volume: 92 Issue: 3 Pages: 1177-1188
- DOI
  10.1007/s00204-017-2112-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18932, KAKENHI-PROJECT-15H04661, KAKENHI-PROJECT-17J03861
[Journal Article] Metabolic activation of cholestatic drug-induced bile acid-dependent toxicity in human sandwich-cultured hepatocytes2017
- Author(s)
  Eiichiro Ogimura, Mayuko Tokizono, Shuichi Sekine, Tetsuya Nakagawa, Kiyoko Bando, Kousei Ito
- Journal Title
  
  J Pharm Sci.
  
  Volume: 印刷中 Issue: 6 Pages: 1799-1799
- DOI
  10.1016/j.xphs.2016.03.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190
[Journal Article] Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes.2016
- Author(s)
  Liu C, Sekine S, Ito K.
- Journal Title
  
  Toxicol Appl Pharmacol.
  
  Volume: 302 Pages: 23-30
- DOI
  10.1016/j.taap.2016.04.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190
[Journal Article] Quantitative assessment of the effects of sulfamethoxazole on Toxoplasma gondii loads in susceptible WT C57BL/6 mice as an2016
- Author(s)
  Belal US, Norose K, Mohamed RM, Sekine S, Nukaga T, Ito K, Abdellatif MZ, Abdelgelil NH, Yano A.
- Journal Title
  
  Parasitol Int.
  
  Volume: 65 Issue: 1 Pages: 1-4
- DOI
  10.1016/j.parint.2015.09.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26460505
[Journal Article] Inhibition of bile canalicular network formation in rat sandwich cultured hepatocytes by drugs associated with risk of severe liver injury.2016
- Author(s)
  Takemura A, Izaki A, Sekine S, Ito K.
- Journal Title
  
  Toxicol In Vitro.
  
  Volume: 35 Pages: 121-130
- DOI
  10.1016/j.tiv.2016.05.016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190
[Journal Article] Establishment of a drug-induced, bile acid-dependent hepatotoxicity model using HepaRG cells2016
- Author(s)
  Susukida T, Sekine S, Nozaki M, Tokizono M, Oizumi K, Horie T, Ito K
- Journal Title
  
  J Pharm Sci
  
  Volume: 43 Issue: 4 Pages: 1550-1560
- DOI
  10.1016/j.xphs.2016.01.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084, KAKENHI-PROJECT-24390037, KAKENHI-PROJECT-16K08377
[Journal Article] Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences.2016
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Eur J Drug Metab Pharmacokinet.
  
  Volume: 41 Issue: 2 Pages: 93-108
- DOI
  10.1007/s13318-015-0296-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein2015
- Author(s)
  Sekine S, Ito K, Watanabe H, Nakano T, Moriya K, Shintani Y, Fujie H, Tsutsumi T, Miyoshi H, Fujinaga H, Shinzawa S, Koike K, Horie T.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 282 Issue: 3 Pages: 237-243
- DOI
  10.1016/j.taap.2014.12.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390183, KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo.2015
- Author(s)
  Niu X, de Graaf IA, van de Vegte D, Langelaar-Makkinje M, Sekine S, Groothuis GM.
- Journal Title
  
  Toxicol In Vitro.
  
  Volume: 29 Issue: 1 Pages: 168-175
- DOI
  10.1016/j.tiv.2014.10.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460190
[Journal Article] Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes.2015
- Author(s)
  Susukida T, Sekine S, Ogimura E, Aoki S, Oizumi K, Horie T, Ito K.
- Journal Title
  
  Toxicol In Vitro
  
  Volume: 29 Issue: 7 Pages: 1454-1463
- DOI
  10.1016/j.tiv.2015.06.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084
[Journal Article] Metabolic activation of hepatotoxic drug (benzbromarone) induced mitochondrial membrane permeability transition.2015
- Author(s)
  Shirakawa M, Sekine S, Tanaka A, Horie T, Ito K.
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 288 Issue: 1 Pages: 12-18
- DOI
  10.1016/j.taap.2015.06.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-26670084, KAKENHI-PROJECT-24390037
[Journal Article] Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay.2015
- Author(s)
  Susukida T, Sekine S, Nozaki M, Tokizono M, Ito K.
- Journal Title
  
  Drug Metab Dispos
  
  Volume: 43 Issue: 11 Pages: 1760-1768
- DOI
  10.1124/dmd.115.065425
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460190, KAKENHI-PROJECT-24390037
[Journal Article] Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats2014
- Author(s)
  Kosaka, K. Watanabe, T. Susukida, T. Aoki, S. Sekine, S. Kume, T. Ito, K.
- Journal Title
  
  Xenobiotica
  
  Volume: Dec 24 Issue: 6 Pages: 1-7
- DOI
  10.3109/00498254.2014.997820
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390037, KAKENHI-PROJECT-26460190
[Journal Article] Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: Assessing the significance on rat intestinal P-glycoprotein efflux.2013
- Author(s)
  Oga EF, Sekine S, Horie T.
- Journal Title
  
  Drug Metab Pharmacokinet.
- NAID
  50008758069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Ezrin regulates the expression of Mrp2/Abcc2 and Mdr1/Abcb1 along the rat small intestinal tract.2013
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol.
  
  Volume: 305 Issue: 11 Pages: 807-17
- DOI
  10.1152/ajpgi.00187.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] The role of cyclophilin D in interspecies differences in susceptibility to hepatotoxic drug-induced mitochondrial injury.2013
- Author(s)
  Sekine S, Kimura T, Motoyama M, Shitara Y, Wakazono H, Oida H, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 86 Issue: 10 Pages: 1507-1514
- DOI
  10.1016/j.bcp.2013.08.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] Ex Vivo and In Vivo Investigations of the Effects of Extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on Digoxin Transport and Pharmacokinetics: Assessing the Significance on Rat Intestinal P-glycoprotein Efflux2013
- Author(s)
 Oga EF, Sekine S, Horie T.
- Journal Title
 
 Drug Metabolism and Pharmacokinetics
 
 Volume: 28 Issue: 4 Pages: 314-320
- DOI
 10.2133/dmpk.DMPK-12-RG-117
- NAID
 130004463319
- ISSN
 1347-4367, 1880-0920
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina, Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics : Assessing the significance on rat intestinal P-glycoprotein efflux2013
- Author(s)
  Oga EF, Sekine S, Horie T
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 28(4) Pages: 314-20
- NAID
  50008758069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] Ex vivo and in vivo investigations of the effects of extracts of Vernonia amygdalina2013
- Author(s)
  Oga EF, Sekine S, Horie T.
- Journal Title
  
  Carica papaya and Tapinanthus sessilifolius on digoxin transport and pharmacokinetics: Assessing the significance on rat intestinalP-glycoprotein efflux. Drug Metab Pharmacokinet
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Disruption of ZO-1/claudin-4 interaction in relation to inflammatory responses in methotrexate-induced intestinal mucositis.2013
- Author(s)
  Hamada K, Kakigawa N, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 72 Issue: 4 Pages: 757-765
- DOI
  10.1007/s00280-013-2238-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 in rat liver.2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1822(6) Pages: 980-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements.2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol Pharm.
  
  Volume: 9(11) Pages: 3023-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 inrat liver2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1822(6) Pages: 980-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers : the influence of herbals on digoxin transport2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistanceassociated protein 2 in rat liver2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Potential P-glycoprotein-mediated drug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87 Issue: 1 Pages: 64-69
- DOI
  10.4269/ajtmh.2012.11-0817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol Pharm
  
  Volume: 9(11) Pages: 3023-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg.
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements.2012
- Author(s)
  Ueda K, Higashi K, Limwikrant W, Sekine S, Horie T, Yamamoto K, Moribe K.
- Journal Title
  
  Mol. Pharm.
  
  Volume: 9 Issue: 11 Pages: 3023-3033
- DOI
  10.1021/mp300083e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172, KAKENHI-PROJECT-24590045
[Journal Article] Potential P-glycoprotein-mediateddrug-drug interactions of antimalarial agents in Caco-2 cells2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  Am J Trop Med Hyg
  
  Volume: 87(1) Pages: 64-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144(3) Pages: 612-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistanceassociated protein 2 in rat liver.2012
- Author(s)
  Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1822 Issue: 6 Pages: 980-987
- DOI
  10.1016/j.bbadis.2012.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003, KAKENHI-PROJECT-22790146, KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] P-glycoprotein mediated efflux in Caco-2 cell monolayers: the influence of herbals on digoxin transport.2012
- Author(s)
  Oga EF, Sekine S, Shitara Y, Horie T.
- Journal Title
  
  J Ethnopharmacol.
  
  Volume: 144 Issue: 3 Pages: 612-617
- DOI
  10.1016/j.jep.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073, KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 81(1) Pages: 178-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status.2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status.2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrugresistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status.2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  BiochemBiophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Yano K, Hashimoto N, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81 Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1812(11) Pages: 1427-1434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 416(3-4) Pages: 313-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats2011
- Author(s)
  Saeki J, Sekine S, Horie T
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes2011
- Author(s)
  Ogimura E, Sekine S, Horie T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Yano K, Hashimoto N, Horie T.
- Journal Title
  
  Biochem Pharmacol. 81(1)
  
  Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.2011
- Author(s)
  Ogimura E, Sekine S, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 416(3-4) Pages: 313-317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1812(11) Pages: 1427-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes2011
- Author(s)
  Ogimura E, Sekine S, Horie T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 416(3-4) Issue: 3-4 Pages: 313-7
- DOI
  10.1016/j.bbrc.2011.11.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats2011
- Author(s)
  Saeki J, Sekine S, Horie T
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Issue: 1 Pages: 178-84
- DOI
  10.1016/j.bcp.2010.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2(Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Yano K, Hashimoto N, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81 Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659073
[Journal Article] Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status2011
- Author(s)
  Sekine S, Ito K, Saeki J, Horie T
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1812(11) Issue: 11 Pages: 1427-34
- DOI
  10.1016/j.bbadis.2011.07.015
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats.2011
- Author(s)
  Saeki J, Sekine S, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 81(1) Pages: 178-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790172
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.2010
- Author(s)
  Maeda, T., Miyazono, Y., Ito.K., Hamada, K., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. 65
  
  Pages: 1117-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada, K., Shitara, Y., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun. 399(2)
  
  Pages: 279-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada K, Shiara Y, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol. 66(6)
  
  Pages: 1031-1038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.2010
- Author(s)
  Maeda T, Miyazono Y, Ito K, Hamada K, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 65(6) Pages: 1117-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 399 Pages: 279-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats.2010
- Author(s)
  Hamada K, Shitara Y, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 66(6) Pages: 1031-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in therat.2010
- Author(s)
  Yano K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 80(4) Pages: 533-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys ResCommun.
  
  Volume: 399(2) Pages: 279-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Zonula Occludens-1 alterations and enhanced intestinal permeability in methotrexate-treated rats2010
- Author(s)
  Hamada, K., Shitara, Y., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats2010
- Author(s)
  Maeda, T., Miyazono, Y., Ito.K., Hamada, K., Sekine, S., Horie, T.
- Journal Title
  
  Cancer.Chemother.Pharmacol. 65
  
  Pages: 1117-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Oxidative stress is a triggering factor for LPS-induced Mrp2 internali zation in the cryopreserved rat and human liver slices.2010
- Author(s)
  Sekine S, Yano K, Saeki J, Hashimoto N, Fuwa T, Horie T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 399 Pages: 279-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat.2010
- Author(s)
  Yoan K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol. 80(4)
  
  Pages: 533-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat.2010
- Author(s)
  Yano K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 80 Pages: 533-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats.2010
- Author(s)
  Maeda T, Miyazono Y, Ito K, Hamada K, Sekine S, Horie T.
- Journal Title
  
  Cancer Chemother Pharmacol. 65(6)
  
  Pages: 1117-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp2 in the rat.2010
- Author(s)
  Yano K, Sekine S, Nemoto K, Fuwa T, Horie T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 80 Pages: 533-539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] The effect of dimerumic acid on LPS-induced downregulation of Mrp 2 in the rat2010
- Author(s)
  Yano, K., Sekine, S., Nemoto, K., Fuwa, Toru., Horie, T.
- Journal Title
  
  Biochemical Pharmacology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphoryl ation status of ezrin in rat intestine2009
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T
- Journal Title
  
  Drug Metab Dispos (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Journal Title
  
  Drug Metab Dispos. 37(7)
  
  Pages: 1521-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Canalicular Mrp2 localization is reversibly regulated by the intracellular redox status.2009
- Author(s)
  Sekine S, Ito K, Horie T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 295(5)
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano, T., Sekine, S., Ito, K., Horie, T.
- Journal Title
  
  Drug.Metab.Dispos. 37
  
  Pages: 1521-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Posttranslational regulation of Abcc2 expression by SUMOylation system2009
- Author(s)
  Minami S, Ito K, Honma M, I kebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 296(5)
  
  Pages: 406-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Journal Title
  
  Drug Metab Dispos. (Epub ahead of print)
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Posttranslational regulation of Abcc2 expression by SUMOylation system.2009
- Author(s)
  Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296(5)
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine2009
- Author(s)
  Nakano, T., Sekine, S., Ito, K., Horie, T.
- Journal Title
  
  Drug.Metab.Dispos. 37
  
  Pages: 1521-1527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine.2009
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 37(7) Pages: 1521-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249003
[Journal Article] Posttranslational regulation of Abcc2 expression by SUMOylation system2009
- Author(s)
  Minami, S., Ito, K., Honma, M., Ikebuchi, Y., Anzai, N., Kanai, Y., Nishida, T., Tsukita, S., Sekine, S., Horie, T., Suzuki, H.
- Journal Title
  
  Am.J.Physiol.Gastrointest.Liver.Physiol. 296
  
  Pages: 406-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Canalicular Mrp2 localization is reversibly regulated by the intracellular redox status2008
- Author(s)
  Sekine S, Ito K, Horie T.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol 295(5)
  
  Pages: 1035-1041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790116
[Journal Article] Posttranslational regulation of Abcc2 expression by SUMO ylation system.2008
- Author(s)
  Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol. 296(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790141
[Journal Article] Oxidative stress and Mrp2 internalization.2006
- Author(s)
  Sekine S, Ito K, Horie T.
- Journal Title
  
  Free Radic Biol Med. 40(12)
  
  Pages: 2166-74
- Data Source
  KAKENHI-PROJECT-18390012
[Journal Article] Ethacrynic acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver2004
- Author(s)
  Ji B, Ito K, Sekine S, Tajima A, Horie T
- Journal Title
  
  Free Radic.Biol.Med. 37(11)
  
  Pages: 1718-1729
- Data Source
  KAKENHI-PROJECT-16390014
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011-06-18
- Data Source
  KAKENHI-PROJECT-21249003
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23659073
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  関根秀一、堀江利治
- Industrial Property Rights Type
  特許
- Filing Date
  2011-05-08
- Acquisition Date
  2012-07-03
- Data Source
  KAKENHI-PROJECT-21249003
[Patent]2011
- Inventor(s)
  関根秀一 , 堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-21249003
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011-07-23
- Data Source
  KAKENHI-PROJECT-23790172
[Patent] 被験化合物の肝毒性を評価する方法および肝毒性を有する化合物のスクリーニング方法2011
- Inventor(s)
  関根秀一、堀江利治
- Industrial Property Rights Holder
  千葉大学
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 肝再生過程の阻害が薬物性肝障害の増悪に与える影響2018
- Author(s)
  竹村晃典、宮思敏、関根秀一、伊藤晃成
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K06744
[Presentation] Evaluation of Immune-Mediated Idiosyncratic Drug Toxicity Using Chimeric HLA Transgenic Mice.2018
- Author(s)
  Susukida T, Aoki S, Kogo K, Fujimori S, Song B, Liu C, Sekine S, Ito K
- Organizer
  57thSOT Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04661
[Presentation] 劇症肝炎誘発薬による肝再生過程の阻害が肝障害増悪に及ぼす影響2018
- Author(s)
  竹村晃典、宮思敏、関根秀一、伊藤晃成
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K06744
[Presentation] 4CYPs導入HepG2細胞における代謝物を考慮したミトコンドリア毒性評価2018
- Author(s)
  14.宮思敏、川口萌実、関根秀一、竹村晃典、佐藤大介、香月康宏、押村光雄、堀江透、伊藤晃成
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18K06744
[Presentation] 劇症肝炎誘発薬物による肝再生能の阻害を介した肝障害増悪に与える影響の評価2018
- Author(s)
  竹村晃典、関根秀一、伊藤晃成
- Organizer
  第25回HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-18K06744
[Presentation] 化粧品原料による胆汁うっ滞型肝障害発症リスク予測法の検証2016
- Author(s)
  薄田健史, 関根秀一, 時園茉由子, 廣田衞彦, 田村亜紀子, 桑田奈々, 上月裕一, 伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 全身毒性試験の代替法を目指したIn vitro肝毒性評価試験法の開発2016
- Author(s)
  関根秀一、川口萌実、額賀巧、劉聡、竹村晃典、薄田健史、廣田衞彦、太枝志帆、田村亜紀子、足利太可雄、上月裕一、伊藤晃成
- Organizer
  第29回日本動物実験代替法学会
- Place of Presentation
  博多
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 薬剤性肝障害の感受性を決めるミトコンドリア毒性評価2016
- Author(s)
  関根秀一
- Organizer
  第23回HAB研究機構学術年会
- Place of Presentation
  つくば
- Year and Date
  2016-05-26
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 毛細胆管伸長阻害に着目した薬剤性肝障害増悪リスク評価系の構築2016
- Author(s)
  伊藤晃成, 関根秀一, 竹村晃典, 伊崎彩, 額賀巧
- Organizer
  第136年会　日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Relationship between increased drug sensitivity of mitochondria in type 2 diabetes and drug induced liver injury2016
- Author(s)
  Masahiro Segawa, Shuichi Sekine, Tomoyuki Sato, Koichi Arakawa, Yugo Ikeyama, Kosuke Saito, Yoshiro Saito, Kousei Ito
- Organizer
  第31回日本薬物動態学会年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 肝毛細胆管形成阻害に着目した肝障害評価法の構築2016
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第23回HAB研究機構学術年会
- Place of Presentation
  つくば
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] ヒト・ラット初代肝細胞を用いたミトコンドリア障害に起因する薬剤性肝毒性の評価2016
- Author(s)
  劉聡, 関根秀一, 伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Evaluation of Drug-induced, Bile acids-dependent Hepatocyte Toxicity in HepaRG cells2016
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono, Kumiko Oizumi, and Kousei Ito 6/24-25
- Organizer
  The 1stWorkshop for Japan-Korea Young Scientists on Pharmaceutics
- Place of Presentation
  京都
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] HepaRG細胞を用いた薬剤性胆汁うっ滞型肝障害発症リスク予測法の確立2016
- Author(s)
  薄田健史, 関根秀一, 野崎麻友香, 時園茉由子, 大泉久美子, 堀江利治, 伊藤晃成
- Organizer
  第11回トランスポーター研究会
- Place of Presentation
  京都
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Consideration of the role of drug metabolism on sandwich cultured hepatocytes-based cholestatic drug induced liver injury assay2016
- Author(s)
  Mayuko Tokizono, Shuichi Sekine, Eiichiro Ogimura, Takeshi Susukida, Kousei Ito
- Organizer
  第31回日本薬物動態学会年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Assessment of mitochondrial dysfunction induced hepatotoxicity using primary rat hepatocytes and cryopreserved human hepatocytes2016
- Author(s)
  Cong Liu, Shuichi Sekine, Kousei Ito
- Organizer
  第31回日本薬物動態学会年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] トログリタゾンによる肝ミトコンドリア透過性遷移へのカルジオリピンの関与2016
- Author(s)
  佐藤智之, 関根秀一, 瀬川雅博, 齊藤公亮, 斎藤嘉朗, 伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] サンドイッチ培養HepG2細胞を用いた毛細胆管形成阻害の評価2016
- Author(s)
  額賀巧, 関根秀一, 廣田衛彦, 田村亜紀子, 桑田奈々, 上月裕一, 伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 臓器特異的なミトコンドリア毒性とリン脂質解析2016
- Author(s)
  瀬川雅博, 齊藤公亮, 関根秀一, 斎藤嘉朗, 伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 一過性虚血による薬剤性肝障害増悪機序の解明第23回HAB研究機構学術年会2016
- Author(s)
  佐藤智之, 荒川公一, 関根秀一, 瀬川雅博, 伊藤晃成
- Organizer
  第23回HAB研究機構学術年会
- Place of Presentation
  つくば
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Crabtree効果の回避によるミトコンドリア脂質代謝への影響2016
- Author(s)
  関根秀一, 大泉久美子, 川口萌実, 廣田衛彦, 田村亜紀子, 桑田奈々, 上月裕一,伊藤晃成
- Organizer
  第43回日本毒性学会
- Place of Presentation
  名古屋
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Mechanism based integrated assay systems for the prediction of drug induced liver injury2016
- Author(s)
  Shuichi Sekine, Moemi Kawaguchi, Takumi Nukaga, Takeshi Susukida, Akinori Takemura, Cong Liu, Morihiko Hirota, Shiho Ooeda, Akiko Tamura, Nana Kuwata, Hirokazu Kouzuki, Kousei Ito
- Organizer
  第31回日本薬物動態学会年会
- Place of Presentation
  松本
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] LPS前投与ラットにおける薬剤性肝障害増強のメカニズム研究2015
- Author(s)
  荒川公一、関根秀一、佐藤智之、伊藤晃成
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] キメラ型HLA遺伝子導入マウスを用いた細胞性免疫による特異体質薬物毒性の発現メカニズム解明2015
- Author(s)
  藤森惣大、青木重樹、向後晃太郎、劉聡、関根秀一、伊藤晃成
- Organizer
  第38回　日本分子生物学会年会、第88回　日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04661
[Presentation] Troglitazone-sulfate strongly inhibits bile canalicular network formation in vitro2015
- Author(s)
  Akinori Takemura, Aya Izaki, Shuichi Sekine, Kousei Ito
- Organizer
  第30年会　日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Crabtree効果を回避した薬物誘発性ミトコンドリア脂質代謝異常のin vitro評価系の構築2015
- Author(s)
  大泉久美子、関根秀一、廣田衛彦、田村亜紀子、桑田奈々、上月裕一、伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] キメラ型HLA遺伝子導入マウスを活用した免疫系の関与する特異体質薬物毒性発症機構の理解2015
- Author(s)
  青木重樹、向後晃太郎、劉聡、藤森惣大、関根秀一、伊藤晃成
- Organizer
  第42回日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-15K14995
[Presentation] Troglitazone-sulfate strongly inhibits bile canalicular network formation in vitro2015
- Author(s)
  Akinori Takemura, Aya Izaki, Shuichi Sekine, Kousei Ito
- Organizer
  第30年会日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] SANDWICH CULTURED HUMAN HEPATOCYTE ASSAY FOR PREDICTION OF THE CLINICAL RISK OF CHOLESTATIC DRUG-INDUCED LIVER INJURY2015
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito
- Organizer
  第30年会　日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] ヒトサンドイッチ培養肝細胞を用いた薬剤性胆汁うっ滞型肝障害発症リスク予測法2015
- Author(s)
  薄田健史、関根秀一、野崎麻友香、時園茉由子、廣田衞彦、田村亜紀子、桑田奈々、上月裕一、伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Crabtree効果の回避による薬物誘発性ミトコンドリア脂質代謝異常への影響2015
- Author(s)
  大泉久美子、関根秀一、伊藤晃成
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] CHIMERIC HLA-B*57:01 TRANSGENIC MICE ENABLE THE COMPREHENSION OF IMMUNE-MEDIATED DRUG HYPERSENSITYVITY REACTIONS2015
- Author(s)
  Cong Liu, Shigeki Aoki, Kotaro Kogo, Sota Fujimori, Shuichi Sekine, Kousei Ito
- Organizer
  第30年会日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] キメラ型HLA遺伝子導入マウスを用いた細胞性免疫による特異体質薬物毒性の発現メカニズム解明2015
- Author(s)
  藤森惣大、青木重樹、向後晃太郎、劉聡、関根秀一、伊藤晃成
- Organizer
  第38回、第88回日本分子生物学会年会、日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] CHIMERIC HLA-B*57:01 TRANSGENIC MICE ENABLE THE COMPREHENSION OF IMMUNE-MEDIATED DRUG HYPERSENSITYVITY REACTIONS2015
- Author(s)
  Cong Liu, Shigeki Aoki, Kotaro Kogo, Sota Fujimori, Shuichi Sekine, Kousei Ito
- Organizer
  第30年会　日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] ヒトサンドイッチ培養肝細胞を用いた薬剤性胆汁うっ滞型肝障害発症リスク予測法2015
- Author(s)
  薄田健史、関根秀一、野崎麻友香、時園茉由子、廣田衞彦、田村亜紀子、桑田奈々、上月裕一、伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 薬剤性肝障害の感受性を決めるミトコンドリアの関与2015
- Author(s)
  関根秀一、伊藤晃成
- Organizer
  第30年会日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 胆汁酸排泄トランスポーター阻害を介した薬剤性肝障害のリスク評価2015
- Author(s)
  関根　秀一
- Organizer
  第19回　動態談話会夏セミナー
- Place of Presentation
  東京
- Year and Date
  2015-08-19
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Crabtree効果を考慮した薬物誘発性ミトコンドリア障害に起因する肝毒性評価系の構築2015
- Author(s)
  劉聡、関根秀一、伊藤晃成
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] LPS併用薬剤性肝障害モデルラットにおけるミトコンドリア機能評価2015
- Author(s)
  荒川公一, 関根秀一, 伊藤晃成
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] PREDICTION OF THE CLINICAL RISK OF DRUG-INDUCED CHOLESTATIC LIVER INJURY USING AN IN VITRO SANDWICH CULTURED HEPATOCYTE ASSAY2015
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito
- Organizer
  第9回　次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 肝毛細胆管形成を指標にした肝障害発症リスク評価法の構築2015
- Author(s)
  竹村晃典、伊崎彩、関根秀一、伊藤晃成
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] サンドイッチ培養肝細胞を用いた薬剤性胆汁うっ滞時における胆道系酵素の細胞内動態評価2015
- Author(s)
  額賀巧、関根秀一、伊藤晃成、千田耕輔、田口明子
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] ラットサンドイッチ培養肝細胞を用いたミトコンドリア障害に起因する薬物誘発性肝毒性評価系の構築2015
- Author(s)
  川口萌実、劉聡、関根秀一、伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] SANDWICH CULTURED HUMAN HEPATOCYTE ASSAY FOR PREDICTION OF THE CLINICAL RISK OF CHOLESTATIC DRUG-INDUCED LIVER INJURY2015
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito
- Organizer
  第30年会　日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] キメラ型HLA遺伝子導入マウスを活用した免疫系の関与する特異体質薬物毒性発症機構の理解2015
- Author(s)
  青木重樹、向後晃太郎、劉聡、藤森惣大、関根秀一、伊藤晃成
- Organizer
  第42回日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 薬剤性肝障害の感受性を決めるミトコンドリアの関与2015
- Author(s)
  関根秀一、伊藤晃成
- Organizer
  第30年会　日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 肝毛細胆管形成を指標にした肝障害発症リスク評価法の構築2015
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 化粧品におけるin vitro肝毒性評価の戦略2015
- Author(s)
  伊藤晃成、関根秀一
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] キメラ型HLA遺伝子導入マウスを用いた細胞性免疫による特異体質薬物毒性の発現メカニズム解明2015
- Author(s)
  藤森惣大、青木重樹、向後晃太郎、劉聡、関根秀一、伊藤晃成
- Organizer
  第38回、第88回日本分子生物学会年会、日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14995
[Presentation] 肝毛細胆管形成を指標にした肝障害発症リスク評価法の構築2015
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第9回　次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] PREDICTION OF THE CLINICAL RISK OF DRUG-INDUCED CHOLESTATIC LIVER INJURY USING AN IN VITRO SANDWICH CULTURED HEPATOCYTE ASSAY2015
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono and Kousei Ito
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 肝毛細胆管形成を指標にした肝障害発症リスク評価法の構築2015
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第28回大会　日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] サンドイッチ培養肝細胞を用いた薬剤性胆汁うっ滞時における胆道系酵素の細胞内動態評価2015
- Author(s)
  額賀巧、関根秀一、千田耕輔、田口明子、伊藤晃成
- Organizer
  第14回　次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] キメラ型HLA遺伝子導入マウスを活用した免疫系の関与する特異体質薬物毒性発症機構の理解2015
- Author(s)
  青木重樹、向後晃太郎、劉聡、藤森惣大、関根秀一、伊藤晃成
- Organizer
  第42回　日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] LPS前投与ラットにおける薬剤性肝障害感受性増強のメカニズム研究2015
- Author(s)
  荒川公一、関根秀一、佐藤智之、伊藤晃成：第42回金沢
- Organizer
  日本毒性学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] サンドイッチ培養肝細胞における薬剤毒性評価と薬剤性胆汁うっ滞リスクの相関性の検討2014
- Author(s)
  野崎麻友香、関根秀一、伊藤晃成
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 血管側胆汁酸排泄輸送体MRPs阻害薬物による胆汁酸依存性肝細胞障害に関する検討2014
- Author(s)
  薄田健史、関根秀一、青木重樹、伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 血管側胆汁酸排泄輸送体MRPs阻害薬物による胆汁酸依存性肝細胞障害に関する検討2014
- Author(s)
  薄田健史、関根秀一、青木重樹、伊藤晃成
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 血管側胆汁酸排泄輸送体mrps阻害薬物による胆汁酸依存性肝細胞障害に関する検討2014
- Author(s)
  薄田健史, 関根秀一, 青木重樹, and 伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Crabtree効果を考慮した薬物誘発性肝細胞毒性評価系の構築2014
- Author(s)
  劉聡, 関根秀一, 伊藤晃成
- Organizer
  第 58 回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Crabtree効果を考慮した薬物誘発性肝細胞毒性評価系の構築2014
- Author(s)
  劉聡、関根秀一、伊藤晃成
- Organizer
  第５８回　日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Lps併用薬剤性肝障害モデルラットにおけるミトコンドリア機能評価2014
- Author(s)
  荒川公一, 関根秀一, 田中彩華, 劉聡, and 伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] サンドイッチ培養肝細胞における薬剤毒性評価と薬剤性胆汁うっ滞リスクの相関性の検討2014
- Author(s)
  野崎麻友香、関根秀一、伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 胆汁酸排泄輸送体阻害に伴う肝細胞毒性に寄与する胆汁酸分子種の解析2014
- Author(s)
  深貝明子、関根秀一、大泉久美子、伊藤晃成
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 特異体質毒性評価に利用可能なヒト-マウスキメラ型HLA遺伝子の構築2014
- Author(s)
  向後晃太郎、青木重樹、関根秀一、伊藤晃成
- Organizer
  第５８回　日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Hepatotoxic drugs-induced metabolic-dependent mitochondrial toxicity2014
- Author(s)
  Shuichi Sekine, Maho Shirakawa, Ayaka Tanaka, Toshiharu Horie, Kousei Ito
- Organizer
  19th North American International Society for the Study of Xenobiotics and 29th JSSX Meeting
- Place of Presentation
  Sanfrancisco, 米国
- Year and Date
  2014-10-19
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] サンドイッチ培養肝細胞での胆汁酸依存的毒性増強に関わる胆汁酸分子種の同定2014
- Author(s)
  大泉久美子、関根秀一、深貝明子、伊藤晃成
- Organizer
  第36回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] LPS併用薬剤性肝障害モデルラットにおけるミトコンドリア機能評価2014
- Author(s)
  荒川公一、関根秀一、田中彩香、劉聡、伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 胆汁酸排泄輸送体阻害に伴う肝細胞毒性に寄与する胆汁酸分子種の解析2014
- Author(s)
  深貝明子, 関根秀一, 大泉久美子, and 伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 反応性代謝物を考慮した薬剤性肝障害発症におけるミトコンドリア毒性の関与2014
- Author(s)
  田中彩香、関根秀一、白川真帆、堀江利治、伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Optimization of Cell-based assay for assessment of mitochondrial dysfunction induced hepatotoxicity2014
- Author(s)
  Cong Kiu, Shuichi Sekine, Kousei Ito
- Organizer
  日本動物実験代替法学会　第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 胆汁酸排泄輸送体阻害に伴う肝細胞毒性に寄与する胆汁酸分子種の解析2014
- Author(s)
  4深貝明子、関根秀一、大泉久美子、伊藤晃成
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] LPS併用薬剤性肝障害モデルラットにおけるミトコンドリア機能評価2014
- Author(s)
  荒川公一、関根秀一、田中彩華、劉聡、伊藤晃成
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 反応性代謝物を考慮した薬剤性肝障害発症におけるミトコンドリア毒性の評価2014
- Author(s)
  田中彩華、関根秀一、白川真帆、堀江利治、伊藤晃成
- Organizer
  日本薬学会第１３４年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 特異体質毒性評価に利用可能なヒトーマウスキメラ型HLA遺伝子の構築2014
- Author(s)
  向後晃太郎, 青木重樹, 関根秀一, 伊藤晃成
- Organizer
  第 58 回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] サンドイッチ培養肝細胞を用いた胆汁うっ滞型薬剤性肝障害発症リスク予測法の有用性2014
- Author(s)
  薄田健史, 関根秀一, 野崎麻友香, 松井等, 長田智治,堀江利治, 伊藤晃成
- Organizer
  第36回胆汁酸研究会
- Place of Presentation
  東京
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] HepaRG細胞を用いた薬物誘発性胆汁酸依存性毒性の評価系の確立2013
- Author(s)
  薄田健史、関根秀一、荻村栄一郎、橋本希美、伊藤晃成、堀江利治
- Organizer
  第40回日本毒性学会
- Place of Presentation
  千葉
- Year and Date
  2013-06-17
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] ミトコンドリアの毒性感受性決定因子としてのミトコンドリア内GSH量の検討2013
- Author(s)
  白川真帆、関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知
- Year and Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] サンドイッチ培養肝細胞を用いた胆汁うっ滞性肝障害誘発薬物の毒性評価系の構築2013
- Author(s)
  関根秀一、薄田健史、堀江利治、伊藤晃成
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-11-22
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] メトトレキサート誘発性消化管障害における好中球浸潤の関与2013
- Author(s)
  関根秀一、浅田千晶、前田友子、書川尚子、堀江利治
- Organizer
  第40回日本毒性学会
- Place of Presentation
  千葉
- Year and Date
  2013-06-17
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] The involvement of basal efflux of bile acids on drug induced bile acids-dependnt hepatotoxicity in rat sandwich cultured hepatocytes2013
- Author(s)
  薄田健史、関根秀一、
- Organizer
  第28回　日本薬物動態学会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] サンドイッチ培養肝細胞を用いた胆汁うっ滞性肝障害誘発薬物の毒性評価系の構築2013
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治、伊藤晃成
- Organizer
  第３５回　生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学薬学部
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 肝毛細胆管形成過程に及ぼす薬物暴露の影響2013
- Author(s)
  伊崎彩, 竹村晃典, 関根秀一, and 伊藤晃成
- Organizer
  第35 回胆汁酸研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Establishment od in vitro screening system for the reactive metabolite induced mitochondrial toxicity2013
- Author(s)
  田中彩華、関根秀一、白川真帆、堀江利治、伊藤晃成
- Organizer
  第28回　日本薬物動態学会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] The involvement of basal efflux of bile acids on drug induced bile acids-dependent hepatotoxicity in rat sandwich cultured hepatocytes2013
- Author(s)
  薄田健史、関根秀一、伊藤晃成
- Organizer
  第28回日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 胆汁うっ滞型肝障害における胆汁酸蓄積を制御する血管側輸送体の関与2013
- Author(s)
  薄田健史, 関根秀一, 荻村栄一朗, 堀江利治, and 伊藤晃成
- Organizer
  第 57 回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] メトトレキサート誘発性消化管障害における好中球浸潤の関与2013
- Author(s)
  関根秀一、浅田千晶、前田智子、書き川尚子、堀江利治
- Organizer
  第40回　日本毒性学会年会
- Place of Presentation
  幕張メッセ　国際会議場
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] The Involvement of Basal Efflux of Bile Acids on Drug Induced Bile Acids-Dependent Hepatotoxicity in Rat Sandwich Cultured Hepatocytes2013
- Author(s)
  T. Susukida, S. Sekine, E. Ogimura, T. Horie, and K. Ito
- Organizer
  28th JSSX meeting
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Establishment of in vitro screening system for the reactive metabolite induced mitochondrial toxicity2013
- Author(s)
  田中彩香、関根秀一、白川真帆、堀江利治、伊藤晃成
- Organizer
  第28回日本薬物動態学会
- Place of Presentation
  東京
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 肝毛細胆管形成過程に及ぼす薬物暴露の影響2013
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, and 伊藤晃成
- Organizer
  第 57 回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] ミトコンドリアの毒性感受性決定因子としてのミトコンドリア内GSH量の検討2013
- Author(s)
  白川真帆、関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会　第２８年会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] HepaRG細胞を用いた薬物誘発性胆汁酸依存性毒性の評価系の確立2013
- Author(s)
  薄田健史、関根秀一、荻村栄一郎、橋本希美、伊藤晃成、堀江利治
- Organizer
  第40回　日本毒性学会年会
- Place of Presentation
  幕張メッセ　国際会議場
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Interspecies differences in glibenclamide induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes2012
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Ken-ichi Kaneko, Takafumi Nakano, Tomoharu Osada, Hiroshi Iwata, Toshiharu Horie,
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich-cultured hepatocytes enable a predictive evaluation of BSEP/Bsep dysfunction-mediated2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  drug-inducedhepatotoxicity SOT
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治
- Organizer
  第27年会日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Inhibitory effects of high-dose tea cathechins on multidrug resistance associated protein 2 (MRP2) function,2012
- Author(s)
  Emi Okubo, Kenichi Wakabayashi, Toshio Kasamatsu, Naohiro Nishiyama, Shuichi Sekine, Toshiharu Horie
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation]2012
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治
- Organizer
  BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立第27年会日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation]2012
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  酸化ストレス誘発性胆汁っ滞時における胆汁排泄輸送体の局在制御機構の解明肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 生体成分共存下におけるカテキンの安定性とROSの生成2012
- Author(s)
  大久保江美、関根秀一、若林賢一、笠松俊夫、西山直宏、堀江利治
- Organizer
  第20回年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2012-08-25
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 小腸における薬物トランスポーターMRP2/ABCC2、MDR1/ABCB1 の細胞膜局在制御機構の解明2012
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与2012
- Author(s)
  小澤口尚子、関根秀一、堀江利治
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込みの関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第２０回　肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Interspecies differences in glibenclamide induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes2012
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Ken-ichi Kaneko, Takafumi Nakano, Tomoharu Osada, Hiroshi Iwata, Toshiharu Horie,
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation]2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes2012
- Author(s)
  Sekine S, Ogimura E, Horie T
- Organizer
  51th Society of Toxicology meeting
- Place of Presentation
  サンフランシスコ
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁っ滞時における胆汁排泄輸送体の局在制御機構の解明2012
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込みの関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第２０回　肝病態生理研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Toshiharu Horie Sandwich-cultured hepatocytes enable a predictive evaluation of BSEP/Bsep dysfunction-mediated2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura
- Organizer
  drug-induced hepatotoxicity SOT
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根　秀一、薄田　健史、荻村　栄一郎、堀江利治
- Organizer
  日本薬剤学会　第２７年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation]2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛
- Organizer
  新澤靖子C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 生体成分共存下におけるカテキンの安定性とROSの生成2012
- Author(s)
  大久保江美、関根秀一、若林賢一、笠松俊夫、西山直宏、堀江利治
- Organizer
  第20回年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2012-08-25
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス誘発性胆汁っ滞時における排泄輸送体の局在制御機構の解明2012
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 小腸における薬物トランスポーターMRP2/ABCC2、MDR1/ABCB1 の細胞膜局在制御機構の解明2012
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Evaluation of bile acid dependent drug induced liver injury in sandwich cultured hapatocytes2012
- Author(s)
  Sekine, S, Ogimura E, Horie T.
- Organizer
  The 19th International Synposium on Microsomes and Drug Oxidations
- Place of Presentation
  Noordwijik aan Zee、the Netherlands
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Evaluation of bile acid dependent drug induced liver injury in sandwich cultured hapatocytes2012
- Author(s)
  Sekine, S, Ogimura E, Horie T.
- Organizer
  The 19th International Synposium on Microsomes and Drug Oxidations
- Place of Presentation
  Noordwijik aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎の病態悪化に対するミトコンドリア鉄蓄積と鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  肝病態生理研究会
- Place of Presentation
  金沢
- Year and Date
  2012-06-06
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation]2012
- Author(s)
  小澤口尚子,関根秀一
- Organizer
  堀江利治薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Inhibitory effects of high-dose tea cathechins on multidrug resistance associated protein 2 (MRP2) function,2012
- Author(s)
  Emi Okubo, Kenichi Wakabayashi, Toshio Kasamatsu, Naohiro Nishiyama, Shuichi Sekine, Toshiharu Horie
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured rat hepatocytes2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  MDO-ISSX
- Place of Presentation
  Noordwijk aan Zee, The Netherlands
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与2012
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Inhibitory effects of high-dose tea cathechins on multidrug resistance associated protein 2 (MRP2) function,2012
- Author(s)
  Emi Okubo, Kenichi Wakabayashi, Toshio Kasamatsu, Naohiro Nishiyama, Shuichi Sekine, Toshiharu Horie
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured hapatocytes2012
- Author(s)
  Sekine, S, Ogimura E, Horie T.,
- Organizer
  The 19th International Synposium on Microsomes and Drug Oxidations
- Place of Presentation
  Noordwijik aan Zee, the Netherlands
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根　秀一、薄田　健史、荻村　栄一郎、堀江利治
- Organizer
  日本薬剤学会　第２７年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Interspecies differences in glibenclamide induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes2012
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Ken-ichi Kaneko, Takafumi Nakano, Tomoharu Osada, Hiroshi Iwata, Toshiharu Horie,
- Organizer
  the 27th JSSX Annual Meeting
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根秀一、薄田健史、荻村栄一郎、堀江利治
- Organizer
  第27年会日本薬剤学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 小腸における薬物トランスポーターMRP2/ABCC2、MDR1/ABCB1 の細胞膜局在制御機構の解明2012
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与2012
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第132年会日本薬学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Sandwich-cultured hepatocytes enable a predictive evaluation of BSEP/Bsep dysfunction-mediated2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  drug-induced hepatotoxicity SOT
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] BSEP阻害剤による胆汁酸依存的毒性のサンドイッチ培養肝細胞での評価法の確立2012
- Author(s)
  関根　秀一、薄田　健史、荻村　栄一郎、堀江　利治
- Organizer
  日本薬剤学会　第２７年会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured rat hepatocytes2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  MDO-ISSX
- Place of Presentation
  The Netherlands
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwich cultured rathepatocytes2012
- Author(s)
  Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
- Organizer
  Noordwijk aan Zee
- Place of Presentation
  The Netherlands
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質と鉄により誘発される細胞障害増悪に対するミトコンドリア鉄取り込み機構の関与2012
- Author(s)
  伊藤好美、関根秀一、堀江利治
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵,関根秀一,三ツ木香織、伊藤晃成、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Sandwich culutured rat hepatocytes を用いた胆汁酸依存性薬剤肝障害の定量的評価法2011
- Author(s)
  荻村栄一朗, 関根秀一,堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサート誘発性消化管バリア機能障害における好中球浸潤の関与2011
- Author(s)
  書川尚子,関根秀一,浅田千晶、前田智子、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Quantitative evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与2011
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 癌細胞の多剤耐性におけるPDZタンパク質の関与2011
- Author(s)
  長里美希,関根秀一、日比野翔、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝炎時の胆汁排泄輸送体Mrp2の内在化機構の解明2011
- Author(s)
  佐伯淳二郎、関根秀一、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 酸化ストレス誘発性胆汁鬱滞におけるMRP2の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 肝障害誘発性薬物による肝毒性に対する肝ミトコンドリア中のグルタチオン量の関与2011
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第19年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Sandwich culutured rat hepatocytesを用いた胆汁酸依存性薬剤肝障害の定量的評価法2011
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する鉄蓄積の関与2011
- Author(s)
  伊藤好美,関根秀一,堀江利治,小池和彦,森屋恭爾,新谷良澄,藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子, 藤江肇,堤武也,三好秀征,藤永秀剛,新澤靖子
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] POTENTIAL P-GLYCOPROTEIN MEDIATED DRUG-DRUG INTERACTIONS OF SOME ANTI-MALARIALS2011
- Author(s)
  Enoche F.Oga、関根秀一、設楽悦久、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵,関根秀一,三ツ木香織、伊藤晃成、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  日東
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝障害誘発性薬物による肝毒性に対する肝ミトコンドリア中のグルタチオン量の関与2011
- Author(s)
  小澤口尚子,関根秀一,堀江利治
- Organizer
  第19年会日本過酸化脂質・抗酸化物質学会
- Place of Presentation
  仙台
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 癌細胞の多剤耐性におけるPDZタンパク質の関与2011
- Author(s)
  長里美希,関根秀一、日比野翔、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与2011
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 肝炎症時の胆汁排泄輸送体Mrp2の内在化機構解明2011
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] POTENTIAL P-GLYCOPROTEIN MEDIATED DRUG-DRUG INTERACTIONS OF SOME ANTI-MALARIALS2011
- Author(s)
  Enoche F.Oga、関根秀一、設楽悦久、堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する徹蓄積の関与2011
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサート誘発性消化管バリア機能障害における好中球浸潤の関与2011
- Author(s)
  書川尚子,関根秀一,浅田千晶、前田智子、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵、関根秀一、三ツ木香織、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第26年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁うっ滞時におけるMRP2の局在制御機構の解明2011
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝炎症時の胆汁排泄輸送体Mrp2の内在化機構解明2011
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与2011
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Year and Date
  2011-07-11
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2011
- Author(s)
  釘岡里恵,関根秀一,三ツ木香織、伊藤晃成、堀江利治
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第26年会日本薬剤学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁鬱滞におけるMRP2の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 肝炎時の胆汁排泄輸送体Mrp2の内在化機構の解明2011
- Author(s)
  佐伯淳二郎、関根秀一、堀江利治
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡県コンベンションアーツセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Sandwich culutured rat hepatocytesを用いた胆汁酸依存性薬剤肝障害の定量的評価法2011
- Author(s)
  荻村栄一朗, 関根秀一, 堀江利治
- Organizer
  第26回日本薬物動態学会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Sandwich cultured rat hepatocytes を用いた胆汁酸依存性薬剤性肝障害の定量的評価2011
- Author(s)
  荻村栄一朗, 関根秀一,堀江利治
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス誘発性胆汁鬱滞におけるMRP2の局在制御機構の解明2011
- Author(s)
  堀江利治、関根秀一、伊藤晃成
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝炎症時の胆汁排泄輸送体Mrp2の内在化機構解明2011
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第131年会日本薬学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] C型肝炎ウイルスコア蛋白質により誘発されるミトコンドリア障害に対する徹蓄積の関与2011
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 小腸におけるMrp2,Mdr1発現部位差とezrinの発現、リン酸化状態の部位差との関連2010
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] The effect of dimerumic acid on LPS-induced internalization of MRP2 inhuman liver2010
- Author(s)
  Toshiharu Horie, Shuichi Sekine
- Organizer
  International Conference on Gastroenterology(Gastroenterology'10)
- Place of Presentation
  Malta
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滯時のMrp2機能低下に対するジメルミン酸の抑制効果について.2010
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2010
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Canalicular Mrp2 localization is reversibly regulated by the phosphorylation status of its anchoring protein2010
- Author(s)
 Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
 9^<th> International ISSX meeting
- Place of Presentation
 Istanbul, Tukery
- Data Source
 KAKENHI-PROJECT-21790141
[Presentation] 小腸炎症時における薬剤排泄トランスポーターMrp2の機能制御機構の解明.2010
- Author(s)
  小島亮人, 関根秀一, 中埜貴文, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、関根秀一
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Ezrin has a key role in the expression profile of MRP2 and MDR1 along intestinal tract2010
- Author(s)
  Shuichi Sekine, Kousei Ito, Takafumi, Nakano, Toshiharu Horie
- Organizer
  9th International ISSX meeting
- Place of Presentation
  Istanbul, Tukery
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Regulatory mechanism of drug-induced Bsep internalization by construction of screening system for Bsep internalization2010
- Author(s)
  Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMRP2,MDR1発現部位差に対するezrinの関与2010
- Author(s)
  中埜貴文,関根秀一,伊藤晃成,堀江利治
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] メトトレキサートによる小腸上皮バリア機能障害の機序解析.2010
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Canalicular Mrp2 localization is reversibly regulated by the phosphorylation status of its anchoring protein2010
- Author(s)
 Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
 9^<th> International ISSX meeting
- Place of Presentation
 イスタンブール
- Data Source
 KAKENHI-PROJECT-21790141
[Presentation] LPS誘発性胆汁うっ滞時のMrp2機能低下に対するジメルミン酸の抑制効果について2010
- Author(s)
  矢野健太郎,関根秀一,根本華奈子,不破亨,堀江利治
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMrp2, Mdrl発現部位差とezrinの発現、リン酸化状態の部位差との関連2010
- Author(s)
  関根秀一、中埜貴文、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Regulatory mechanism of drug-induced Bsep internalization by construction of screening system for Bsep internalization2010
- Author(s)
  Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2010
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] Ezrin has a key role in the expression profile of MRP2 and MDR1 along intestinal tract2010
- Author(s)
 Shuichi Sekine, Kousei Ito, Takafumi, Nakano, Toshiharu Horie
- Organizer
 9^<th> International ISSX meeting
- Place of Presentation
 イスタンブール
- Data Source
 KAKENHI-PROJECT-21790141
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、関根秀一
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] メトトレキサートによる小腸上皮バリア機能障害の機序解析2010
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 小腸におけるMrp2,Mdr1発現部位差とezrinの発現、リン酸化状態の部位差との関連2010
- Author(s)
  関根秀一、中埜貴文、伊藤晁成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] C型肝炎ウイルスコア蛋白質により誘発される酸化ストレスに対する鉄蓄積の関与2010
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第18回生体パーオキサイド研究会
- Place of Presentation
  仙台
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] The role of Nrf2 on multidrug resistance2010
- Author(s)
  Masahiro Ono, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] LPS-induced Mrp2 internalization is due to the dissociation of Mrp2 and radixin2010
- Author(s)
  Junjiro Saeki, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 薬剤性ミトコンドリア障害感受性における動物種差の検討2010
- Author(s)
  本山碧、関根秀一、木村友映、堀江利治
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] Canalicular Mrp2 localization is reversibly regulated by the phosphorylation status of its anchoring protein_2010
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  9th International ISSX meeting
- Place of Presentation
  Istanbul, Tukery
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性Mrp2内在化におけるMrp2-radixin間相互作用解消の関与2010
- Author(s)
  佐伯淳二郎,関根秀一,堀江利治
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2010
- Author(s)
  関根秀一、設楽悦久、堀江利治
- Organizer
  37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆針うっ滞時のMrp2機能低下に対するジメルミン酸の抑制効果について2010
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] The role of Nrf2 on multidrug resistance2010
- Author(s)
  Masahiro Ono, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 肝臓及び小腸における Estradiol 17β-glucuronide誘発性Mrp2機能低下機構の解明2010
- Author(s)
  松尾玲子, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] C型肝炎ウイルスコア蛋白質により誘発される酸化ストレスに対する鉄蓄積の関与2010
- Author(s)
  伊藤好美、関根秀一、堀江利治、小池和彦、森屋恭爾、新谷良澄、藤江肇、堤武也、三好秀征、藤永秀剛、新澤靖子
- Organizer
  第18回生体パーオキサイド研究会
- Place of Presentation
  仙台
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] Bsep局在スクリーニング系構築による薬剤誘発性Bsep内在化機構の解明2010
- Author(s)
  荻村栄一朗,関根秀一,堀江利治
- Organizer
  第25回日本薬物動態学会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] The role of Nrf2 on multidrug resistance2010
- Author(s)
  Masahiro Ono, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 肝臓及び小腸におけるEstradiol 17β-glucuronide誘発性Mrp2機能低下機構の解明.2010
- Author(s)
  松尾玲子, 関根秀一, 堀江利治
- Organizer
  日本薬学会第130年会講演要旨集(2009)
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬剤性ミトコンドリア障害感受性における動物種差の検討2010
- Author(s)
  本山碧、関根秀一、木村友映、堀江利治
- Organizer
  第32回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山国際会議場
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 薬剤性ミトコンドリア障害感受性における動物種差の検討2010
- Author(s)
  本山碧、関根秀一、木村友映、堀江利治
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] Regulatory mechanism of drug-induced Bsep internalization by construction of screening system for Bsep internalization2010
- Author(s)
  Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] LPS-induced Mrp2 internalization is due to the dissociation of Mrp2 and radixin2010
- Author(s)
  Junjiro Saeki, Shuichi Sekine, Toshiharu Horie
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックホール
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Ezrin has a key role in the expression profile of MRP2 and MDR1 along intestinal tract2010
- Author(s)
 Shuichi Sekine, Kousei Ito, Takafumi, Nakano, Toshiharu Horie
- Organizer
 9^<th> International ISSX meeting
- Place of Presentation
 Istanbul, Tukery
- Data Source
 KAKENHI-PROJECT-21790141
[Presentation] 小腸炎症時における薬剤排泄トラシスポーターMrp2の機能制御機構の解明2010
- Author(s)
  小島亮人, 関根秀一, 中埜貴文, 堀江利治
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 細胞内レドックス状態の変化によるMrp2-radixin複合体の局在制御機構の解明2010
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  あわぎんホール徳島県郷土文化会館
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] The mechanisms of enhanced paracellular permability in the small intestine of MTX-treated rats.2009
- Author(s)
  Hamada, K, Shitara, Y, Sekine, S, Horie, T.
- Organizer
  Advances in Inframmatory Bowel Diseases Crohn's & Colitis Foundation's & Clinical Conference
- Place of Presentation
  Hollywood, USA
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 小腸におけるMrp2発現部位差とezrinリン酸化状態との関連2009
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 小腸におけるMrp2発現部位差とezrinリン酸化状態との関連.2009
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Intracellular redox status reversibly regulates the localization of Mrp2-radixin complex.2009
- Author(s)
  Sekine, S., Ito, K., Horie, T.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Intracellular redox status reversibly regulates the localization of Mrp2-radixin complex2009
- Author(s)
  関根秀一, 伊藤晃成, 堀江利治
- Organizer
  第31 回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] メトトレキサートによる小腸上皮透過性亢進の機序検討.2009
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬剤学会第24年会講演要旨集
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滞における Dimerumic acid の抑制効果について2009
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] LPS誘発性Mrp局在変化へのRadixinの脱リン酸化の関与.2009
- Author(s)
  佐伯淳二郎, 関根秀一, 月田早智子, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Oxidative stress contributes to Methotrexate-induced small intestinal in jury caused by neutrophil infiltration.2009
- Author(s)
  Asada, C., Sekine, S., Miyazono, Y., Maeda, T., Horie, T
- Organizer
  The 1st International Conference on Lipid Hydroperoxide Byology and Medicine Sendai (ICLH2009)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性胆汁うっ滯におけるDimerumic acidの抑制効果について.2009
- Author(s)
  矢野健太郎, 関根秀一, 根本華奈子, 不破亨, 堀江利治
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] LPS誘発性Mrp2局在変化へのRadixinの脱リン酸化の関与2009
- Author(s)
  佐伯淳二郎, 関根秀一, 月田早智子, 堀江利治
- Organizer
  日本薬物動態学会第24回年会学
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2009
- Author(s)
  三ツ木香織、関根秀一、堀江利治
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] Intracellular redox status reversibly regulates the localization of Mrp2-radixin complex.2009
- Author(s)
  Sekine, Shuichi., Ito, Kousei., Horie, Toshiharu.
- Organizer
  第31回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] メトトレキサートによる小腸上皮透過性亢進の機序検討2009
- Author(s)
  濱田和真, 設楽悦久, 関根秀一, 堀江利治
- Organizer
  日本薬剤学会第24年会講演要旨集
- Place of Presentation
  静岡県コンベンションアーツセンター(グランシップ)
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] LPS誘発性Mrp2局在変化へのRadixinの脱リン酸化の関与2009
- Author(s)
  佐伯淳二郎,関根秀一,月田早智子,堀江利治
- Organizer
  第24回日本薬物動態学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与2009
- Author(s)
  三ツ木香織、関根秀一、堀江利治
- Organizer
  第129年会日本薬学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21249003
[Presentation] Oxidative stress contributes to Methotrexate-induced small intestinal in jury caused by neutrophil infiltration2009
- Author(s)
  Asada, C., Sekine, S., Miyazono, Y., Maeda, T., Horie, T
- Organizer
  The 1st International Conference on Lipid Hydroperoxide Byology and Medicine Sendai(ICLH 2009)
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21790141
[Presentation] cPKC活性化が及ぼすラット小腸Mrp2及びMdr1膜局在への影響の相違2008
- Author(s)
  中埜貴文、関根秀一、伊藤晃成、堀江利治
- Organizer
  日本薬物動態学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] LPSにより誘発されるMrp2局在変化に対するdimerumic acidの抑制効果について2008
- Author(s)
  矢野健太郎、関根秀一、堀江利治
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] LPS誘発性胆汁うっ滞に対するDimerumic acidの防御効果について2008
- Author(s)
  根本華奈子、矢野健太郎、関根秀一、平田晃陰、不破享、堀江利治
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] Estradiol 17β-glucuronideの小腸上皮トランスポーターの機能に対する影響について2008
- Author(s)
  松尾玲子、関根秀一、堀江利治
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] Estradiol 17β-glucuromideの小腸上皮トランスポーターの機能に対する影響について2008
- Author(s)
  松尾玲子、関根秀一、堀江利治
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] cAMPとGenipinによる胆汁排泄輸送体Mrp2の膜局在誘導メカニズムの解析2008
- Author(s)
  高島有紀、関根秀一、堀江利治
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] 薬物誘発性ミトコンドリア膜透過性遷移における種差の解明2008
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  日本ミトコンドリア学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] Tha phosphorylation status of ezrin regulates MrP2 localization in rat intestine2007
- Author(s)
  Takahumi Nakano, Shuichi Sekine.Kousei Ito, Toshiharu Horie
- Organizer
  8th Intemational ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Tha phosphorylation status of ezrin regulates Mrp2 localization in rat intestine2007
- Author(s)
  Takahumi Nakano, Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Phosphorylation status of ezrin correlates with membrane localization of Mrp2 in intestine2007
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T.
- Organizer
  126th meeting of pharmaceutical society of japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases.2007
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases2007
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases2007
- Author(s)
  Sekine S, Ito K, Horie T
- Organizer
  8th International ISSX
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] 小腸上皮Mrp2の膜局在と膜裏打ち蛋白質Ezrinのリン酸化状態との関連2007
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬学会第126年会
- Place of Presentation
  富山
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Tha phosphorylation status of ezrin regulates Mrp2 localization in rat intestine2007
- Author(s)
  Nakano T, Sekine S, Ito K, Horie T
- Organizer
  8th International ISSX
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] The balance of PKA/PKC activation reversibly regulates vesicular trafficking of Mrp22007
- Author(s)
  Sekine S, Ito K, Horie T
- Organizer
  29th Symposium on biomembrane-drug interaction
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] PKA/PKC活性化平衡の変動によるMrp2の可逆的膜動輸送制御について2007
- Author(s)
  関根秀一, 伊藤晃成, 堀江利治
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390012
[Presentation] Mrp2 localization is reversibly regulated by protein kinases.2007
- Author(s)
  Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] PKA/PKC活性化平衡の変動によるMrp2の可逆的膜動輸送制御について2007
- Author(s)
  関根秀一, 伊藤晃成, 堀江利治
- Organizer
  第29回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] Tha phosphorylation status of ezrin regulates Mrp2 localization in rat intestine2007
- Author(s)
  Takahumi Nakano, Shuichi Sekine, Kousei Ito, Toshiharu Horie
- Organizer
  8th International ISSX
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] 小腸上皮Mrp2の膜局在と膜裏打ち蛋白質Ezrinのリン酸化状態との関連2007
- Author(s)
  中埜貴文, 関根秀一, 伊藤晃成, 堀江利治
- Organizer
  日本薬学会第126年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19790116
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与
- Author(s)
  釘岡里恵、関根秀一、三ツ木香織、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会　第２６年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Inhibition of basolateral efflux transporter causes drug induced bile acids-dependent hepatotoxicity.
- Author(s)
  Suzukida T, Sekine S, Aoki S, Ito K.
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] トログリタゾン及びその硫酸抱合体による肝毛細胆管形成過程への影響
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 薬剤性胆汁うっ滞型肝障害発症リスク予測におけるサンドイッチ培養肝細胞を用いた肝毒性評価法の有用性
- Author(s)
  薄田健史, 関根秀一, 野崎麻友香, 松井等, 長田智治, 堀江利治, 伊藤晃成
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] FUNCTIONAL ASSESSMENT OF LIVER MITOCHONDRIA FROM LPS-PRETREATED EXPERIMENTAL DILI MODEL
- Author(s)
  Koichi Arakawa, Shuichi Sekine, Kousei Ito
- Organizer
  19th North American International Society for the Study of Xenobiotics
- Place of Presentation
  Sanfrancisco, 米国
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 胆汁酸排泄輸送体の阻害による胆汁酸の蓄積と肝細胞毒性に関わる胆汁酸分子種の同定
- Author(s)
  大泉久美子、関根秀一、深貝明子、伊藤晃成
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与
- Author(s)
  小澤口尚子、関根秀一、堀江利治
- Organizer
  日本薬学会　第１３２年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Eevaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  Sekine S, Ogimura E, Horie T.
- Organizer
  51th　Society of Toxicology meeting
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] マイクロ空間培養プレートを用いた胆汁酸依存的薬剤性肝細胞毒性の評価
- Author(s)
  関根秀一、菊田奈津子、江尻洋子、細田雅也、堀江利治、伊藤晃成
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] サンドイッチ培養肝細胞の肝毛細胆管形成を指標とした肝障害誘発性薬物の評価系の確立
- Author(s)
  伊崎　彩, 竹村　晃典, 関根　秀一, 伊藤　晃成
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] サンドイッチ培養肝細胞を用いた肝毛細胆管形成阻害を指標とした肝障害誘発性薬物評価系の確立
- Author(s)
  伊崎彩, 竹村晃典, 関根秀一, 伊藤晃成.
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Quantitative evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  日本薬物動態学会　第２６回年会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] ヒト、ラットサンドイッチ培養肝細胞を用いた臨床での薬物誘発性胆汁うっ滞型肝障害リスクの予測精度の検討
- Author(s)
  関根秀一, 野崎麻友香, 薄田健史, 堀江利治, 伊藤晃成
- Organizer
  第8回　次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2014-10-15 – 2014-10-16
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 酸化ストレス時におけるMrp2タンパク分解に対するユビキチン様修飾因子の関与
- Author(s)
  釘岡里恵、関根秀一、三ツ木香織、伊藤晃成、堀江利治
- Organizer
  日本薬剤学会　第２６年会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 劇症肝炎誘発薬物による反応性代謝を介した肝ミトコンドリア毒性評価系の構築
- Author(s)
  白川真帆、関根秀一、田中彩華、伊藤晃成
- Organizer
  第41回日本毒性学会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] 薬物誘発性ミトコンドリア障害に起因する肝毒性評価のためのIn vitro細胞培養条件の検討
- Author(s)
  劉聡, 関根秀一, 伊藤晃成
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Troglitazone and its sulfate conjugate cause dysfunction of the bile canalicular network formation
- Author(s)
  Akinori Takemura, Aya Izaki, Shuichi Sekine, Kousei Ito
- Organizer
  19th North American International Society for the Study of Xenobiotics
- Place of Presentation
  Sanfrancisco, 米国
- Year and Date
  2014-10-19 – 2014-10-23
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬剤性肝障害の感受性を決めるミトコンドリアの関与
- Author(s)
  関根秀一、堀江利治、伊藤晃成
- Organizer
  日本動物実験代替法学会　第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-05 – 2014-12-07
- Invited
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Sandwich cultured rat hepatocytesを用いた胆汁酸依存性薬剤性肝障害の定量的評価
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 薬剤性肝障害の感受性を決めるミトコンドリアの関与
- Author(s)
  関根秀一, 堀江利治, 伊藤晃成
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-06 – 2014-12-07
- Invited
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] Evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  Sekine S, Ogimura E, Horie T.
- Organizer
  51th　Society of Toxicology meeting
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] Basal efflux of bile acids contributes to drug-induced bile acid- dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes
- Author(s)
  Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Shigeki Aoki, Toshiharu Horie and Kousei Ito
- Organizer
  日本動物実験代替法学会　第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-26460190
[Presentation] Quantitative evaluation of bile acid dependent drug-induced liver injury in sandwitch cultured rat hepatocytes
- Author(s)
  荻村栄一朗，関根秀一，堀江利治
- Organizer
  日本薬物動態学会　第２６回年会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] トログリタゾン及びその硫酸抱合体による肝毛細胆管形成過程への影響
- Author(s)
  竹村晃典, 伊崎彩, 関根秀一, 伊藤晃成
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 劇症肝炎誘発薬物による代謝依存的な肝ミトコンドリア毒性評価系の構築
- Author(s)
  関根秀一, 白川真帆, 田中彩華, 堀江利治, 伊藤晃成
- Organizer
  日本動物実験代替法学会第27回大会
- Place of Presentation
  横浜
- Year and Date
  2014-12-06 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 酸化ストレス誘発性胆汁うっ滞時におけるMRP2の局在制御機構の解明
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  第３３回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] 薬物誘発性肝障害発生機序における肝ミトコンドリア内グルタチオン量の関与
- Author(s)
  小澤口尚子、関根秀一、堀江利治
- Organizer
  日本薬学会　第１３２年会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-23659073
[Presentation] ヒトにおける特異体質毒性評価を目的としたキメラ. 型 HLA 遺伝子導入マウスの作出
- Author(s)
  向後晃太郎, 青木重樹, 聡劉, 関根秀一, 伊藤晃成
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 薬物誘発性ミトコンドリア感受性の動物間種差におけるCyclophilin Dの関与
- Author(s)
  関根秀一、木村友映、本山碧、堀江利治
- Organizer
  第３８回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] 酸化ストレス誘発性胆汁うっ滞時におけるMRP2の局在制御機構の解明
- Author(s)
  関根秀一、伊藤晃成、堀江利治
- Organizer
  第３３回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山大学
- Data Source
  KAKENHI-PROJECT-23790172
[Presentation] Prediction of the clinical risk of drug-induced cholestatic liver injury from in vitro rat sandwich cultured hepatocytes assay.
- Author(s)
  Ito K, Nozaki M, Horie T, Sekine S.
- Organizer
  5th FIP Pharmaceutical Sciences World Congress
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-04-13 – 2014-04-16
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 胆汁酸排泄輸送体の阻害による胆汁酸の蓄積と肝細胞毒性に関わる胆汁酸分子種の同定
- Author(s)
  大泉久美子, 関根秀一, 深貝明子, 伊藤晃成
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390037
[Presentation] 反応性代謝物を考慮した肝ミトコンドリア毒性評価系の構築
- Author(s)
  白川真帆, 田中彩華, 関根秀一, 伊藤晃成.
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸
- Year and Date
  2014-07-02 – 2014-07-04
- Data Source
  KAKENHI-PROJECT-24390037

1. Ito Kousei (30323405)

# of Collaborated Projects: 6 results

# of Collaborated Products: 99 results
2. HORIE Toshiharu (90120154)

# of Collaborated Projects: 4 results

# of Collaborated Products: 140 results
3. SHITARA Yoshihisa (00306656)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. 青木重樹 (30728366)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 高田龍平 (90376468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 本間雅 (60401072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桝渕泰宏 (10209455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Susukida Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Song Binbin

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Fujimori Sota

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Kogo Kotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 森屋恭爾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小池和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEKINE Shuichi 関根 秀一

Research Projects

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Construction of an in vivo model for prediction of fulminant type DILI in preclinical/clinicalPrincipal Investigator

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Elucidation of the onset mechanism of abacavir-induced severe skin reaction using humanized model animal

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Elucidation of the pathogenesis of idiosyncratic drug-induced liver injury using HLA-transfected mice for establishment of preclinical prediction method

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Fundamental study for integrated understanding of the mechanism of DILI and its predictionPrincipal Investigator

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Basis study for the prediction of fatal DILI risk based on MHC expression in the liver

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Quantitative analysis of drugs induced BSEP inhibition and cholestatic hepatotoxicity

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The role of phosphorylation status of radixin on the localization of billiary transportersPrincipal Investigator

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Molecular analysis of localization of biliary transporters in chronic hepatitis

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Detection of BSEP mediated hepatotoxicity by using the intrahepatic bile acid imaging techniquePrincipal Investigator

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Molecular analysis and biological effect of PKC isoforms dependent membrane trafficking of Mrp2/BsepPrincipal Investigator

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Intrahepatic imaging and molecular analysis of MRP2 localization regulated by the intracellular redox status

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MRP2 mediated defense against oxidative stress in liver

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[Journal Article] Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat2018

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SEKINE Shuichi 関根秀一