Takago Hideki 鷹合秀輝

… Alternative Names

鷹合秀輝タカゴウヒデキ

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Researcher Number	70401354
Other IDs	https://orcid.org/0000-0003-2875-4667
Affiliation (Current)	2025: 昭和医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2016 – 2023: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 研究室長 2015: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 研究室長 2014: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 研究室長 2013: 国立障害者リハビリテーションセンター(研究所), 研究所感覚機能系障害研究部, 室長 2009: 医科歯科大, 医歯(薬)学総合研究科 2008: Tokyo Medical and Dental University, 医学部・附属病院, 医員 2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, COE拠点形成特別研究員
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Basic Section 46030:Function of nervous system-related
Keywords	Principal Investigator 有毛細胞 / 蝸牛 / シナプス / パッチクランプ / グルタミン酸イメージング / リボンシナプス / 内耳 / 蝸牛神経 / Cochlear synaptopathy / 薬剤性難聴 … More / STORM顕微鏡 / パッチクランプ法 / 超解像顕微鏡 / Otoferlin / 聴覚 / 加齢性難聴 / イメージング / グルタミン酸 / リボン / 国際情報交換（ドイツ） / 人工内耳 / オプトジェネティクス / 光遺伝学 / グルタミン酸興奮毒性 / 聴覚系 / ナトリウム / Gタンパク質 / 電位依存性カルシウムチャネル / NMDA受容体 / グルダミン酸興奮毒性 … More Except Principal Investigator グルタミン酸イメージング / カルシウムイメージング / パッチクランプ法 / 神経伝達物質放出 / シナプス伝達 Less

Pathophysiological study of cochlear synaptopathy in drug-induced hearing lossPrincipal Investigator
- Principal Investigator
  
  鷹合秀輝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.
- Principal Investigator
  
  大島知子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  The University of Tokyo
STORM顕微鏡を用いた有毛細胞シナプスにおけるOtoferlinの構造機能解析Principal Investigator
- Principal Investigator
  
  鷹合秀輝
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
Pathophysiological study of age-related hearing loss by glutamate imagingPrincipal Investigator
- Principal Investigator
  
  Takago Hideki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
New method for auditory nerve stimulation using optogeneticsPrincipal Investigator
- Principal Investigator
  
  Takago Hideki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  National Rehabilitation Center for Persons with Disabilities
聴覚系のグルタミン酸興奮毒性についてのパッチクランプ法による検討Principal Investigator
- Principal Investigator
  
  鷹合秀輝
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2008 2007 Other

All Journal Article Presentation

[Journal Article] Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse2019
- Author(s)
  Hideki Takago, Tomoko Oshima-Takago, Tobias Moser
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 11 Pages: 492-492
- DOI
  10.3389/fnmol.2018.00492
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals2018
- Author(s)
  Takago Hideki、Oshima-Takago Tomoko
- Journal Title
  
  Hearing Research
  
  Volume: 362 Pages: 1-13
- DOI
  10.1016/j.heares.2018.02.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups2017
- Author(s)
  Oshima-Takago Tomoko、Takago Hideki
- Journal Title
  
  Open Biology
  
  Volume: 7 Issue: 7 Pages: 170032-170032
- DOI
  10.1098/rsob.170032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11204, KAKENHI-PROJECT-16K18374
[Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015
- Author(s)
  Yoshimoto R, Iwasaki S*, Takago H, Nakajima T, Sahara Y, Kitamura K.
- Journal Title
  
  Neuroscience
  
  Volume: 284 Pages: 632-642
- DOI
  10.1016/j.neuroscience.2014.10.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293347, KAKENHI-PROJECT-25670722
[Journal Article] Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis2014
- Author(s)
  Chapochnikov NM*, Takago H*, Huang CH, Pangrsic T, Khimich D, Neef J, Auge E, Goettfert F, Hell S, Wichmann C, Wolf F, Moser T (* Co-1st authors)
- Journal Title
  
  Neuron
  
  Volume: 83 Issue: 6 Pages: 1389-1403
- DOI
  10.1016/j.neuron.2014.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] キンギョ網膜双極細胞終末端におけるシナプスリボン近位および遠位からのグルタミン酸放出の可視化2023
- Author(s)
  大島知子、坂本寛和、中村行宏、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Spatiotemporal dynamics of glutamate release from individual ribbon and non-ribbon regions in the goldfish retinal bipolar cell terminal.2023
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Probing glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2022
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 99th Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] キンギョ網膜双極細胞リボンシナプスにおけるグルタミン酸イメージング2021
- Author(s)
  大島知子, 坂本寛和, 中村行宏, 並木繁行, 廣瀬謙造, 立花政夫, 鷹合秀輝
- Organizer
  第98回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Unveiling glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2021
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Yukihiro Nakamura, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 44rd Annual Meeting of the Japan Neuroscience Society/ The CJK International Meeting
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] 網膜双極細胞リボンシナプスにおけるグルタミン酸放出の可視化2020
- Author(s)
  大島知子、坂本寛和、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] Novel imaging of glutamate release from the ribbon type synapses of goldfish retinal bipolar cell terminal2020
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  The 43rd Annual Meeting of the Japan Neuroscience Society
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] 内有毛細胞リボンシナプスにおけるBassoonとOtoferlinによるグルタミン酸放出の制御2020
- Author(s)
  鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 網膜双極細胞リボンシナプスにおけるグルタミン酸放出の可視化2020
- Author(s)
  大島知子、坂本寛和、並木繁行、廣瀬謙造、立花政夫、鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] 内有毛細胞リボンシナプスにおけるBassoonとOtoferlinによるグルタミン酸放出の制御2020
- Author(s)
  鷹合秀輝
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Optical measurements of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09880
[Presentation] Bassoon and Otoferlin-dependent regulation of glutamate release at the inner hair cell ribbon synapse2019
- Author(s)
  鷹合秀輝
- Organizer
  第124回日本解剖学会総会全国学術集会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] Optical measurements of glutamate release from multiple ribbon-type synapses at the terminal of goldfish retinal bipolar cell2019
- Author(s)
  Tomoko Oshima-Takago, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose, Masao Tachibana, Hideki Takago
- Organizer
  Ribbon Synapses Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] Presynaptic N-methyl-D-aspartate receptor inhibits Ca2+ currents at a rat central glutamatergic synapse2017
- Author(s)
  Oshima-Takago T, Takago H
- Organizer
  6th Mediterranean Neuroscience Society Conference 2017 MALTA MNS2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 中枢神経系のグルタミン酸作動性シナプスにおいてシナプス前NMDA受容体は電位依存性カルシウムチャネルを抑制する2017
- Author(s)
  鷹合秀輝, 大島知子
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 聴覚中枢におけるNMDA受容体によるシナプス前抑制2017
- Author(s)
  鷹合秀輝, 大島知子
- Organizer
  第62回日本聴覚医学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 若齢ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2017
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  浜松市
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] ラット聴覚中枢におけるシナプス前部NMDA受容体による神経伝達物質放出の抑制2017
- Author(s)
  鷹合秀輝
- Organizer
  第27回日本耳科学会
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] 幼若ラットcalyx of HeldシナプスにおけるNMDA受容体依存性シナプス前抑制2016
- Author(s)
  大島知子, 鷹合秀輝
- Organizer
  生理学研究所シナプス研究会
- Place of Presentation
  岡崎市
- Year and Date
  2016-11-21
- Data Source
  KAKENHI-PROJECT-16K11204
[Presentation] マウス内有毛細胞リボンシナプスにおけるOtoferlinによる神経伝達物質放出の制御2015
- Author(s)
  鷹合　秀輝
- Organizer
  第116回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  東京
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Presynaptic inhibition mediated by AMPARs and NMDARs at the calyx of Held synapse.2008
- Author(s)
  鷹合秀輝、中村行宏、大島-鷹合知子、喜多村健、高橋智幸
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京都新宿区
- Year and Date
  2008-03-25
- Data Source
  KAKENHI-PROJECT-19791196
[Presentation] Presynaptic AMPARs & NMDARs regulate synaptic transmission by inhibiting voltage-gated Ca^<2+> channels at the calyx of Held.2008
- Author(s)
  Takago H, Oshima-Takago T, Nakamura Y, Kitamura K and Takahashi T
- Organizer
  Inner Ear Lab Seminars
- Place of Presentation
  University of Goettingen, Goettingen, Germany
- Year and Date
  2008-01-29
- Data Source
  KAKENHI-PROJECT-19791196
[Presentation] Presynaptic NMDA receptors regulate synaptic transmission by inhibiting voltage-gated calcium channels at a central glutamatergic synapse.2007
- Author(s)
  Takago H, Oshima-Takago T, Kitamura K and Takahashi T
- Organizer
  The Society for Neuroscience 37th Annual Meeting
- Place of Presentation
  San Diego, CA, U.S.A.
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19791196
[Presentation] イオンチャネル型グルミタン酸受容体によるシナプス前抑制2007
- Author(s)
  鷹合秀輝、大島知子、中村行宏、喜多村健、高橋智幸
- Organizer
  第108回日本耳鼻咽喉科学会総会
- Place of Presentation
  金沢市
- Year and Date
  2007-05-17
- Data Source
  KAKENHI-PROJECT-19791196
[Presentation] マウス内有毛細胞求心性シナプスにおけるotoferlinの機能の分析
- Author(s)
  鷹合秀輝, Tobias Moser
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島市）
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Evaluation of synaptic function of otoferlin at the mouse inner hair cell ribbon synapse by postsynaptic recording
- Author(s)
  Hideki Takago, Tobias Moser
- Organizer
  Inner Ear Biology 2014 in Kyoto
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2014-11-01 – 2014-11-04
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] マウス内有毛細胞リボンシナプスにおける神経伝達物質放出様式
- Author(s)
  鷹合　秀輝
- Organizer
  第115回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] マウス内有毛細胞リボンシナプスにおけるBassoonとシナプスリボンによるシナプス伝達の制御
- Author(s)
  鷹合秀輝
- Organizer
  第114回日本耳鼻咽喉科学会総会・学術講演会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Otoferlin alters mode of exocytosis at the inner hair cell ribbon synapse
- Author(s)
  Hideki Takago, Tobias Moser
- Organizer
  The 1st annual meeting of the society for bioacoustics
- Place of Presentation
  Doshisha Biwako Retreat Center
- Year and Date
  2014-12-13 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25670722
[Presentation] Otoferlinはマウス内有毛細胞リボンシナプスにおいてエキソサイトーシスのモードを変える
- Author(s)
  鷹合　秀輝, 大島－鷹合　知子, トビアス　モーザー
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  神戸国際会議場・展示場
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-25670722

1. OSHIMA Tomoko (50731783)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. 中村行宏 (40460696)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 岩崎真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 中島敏明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takago Hideki 鷹合 秀輝

鷹合 秀輝 タカゴウ ヒデキ

Research Projects

Research Products

Co-Researchers

Pathophysiological study of cochlear synaptopathy in drug-induced hearing lossPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the spatio-temporal dynamics of calcium and glutamate coupling at sensory ribbon synapses.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

STORM顕微鏡を用いた有毛細胞シナプスにおけるOtoferlinの構造機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological study of age-related hearing loss by glutamate imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

New method for auditory nerve stimulation using optogeneticsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

聴覚系のグルタミン酸興奮毒性についてのパッチクランプ法による検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Disruption of otoferlin alters the mode of exocytosis at the mouse inner hair cell ribbon synapse2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pre- and postsynaptic ionotropic glutamate receptors in the auditory system of mammals2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NMDA receptor-dependent presynaptic inhibition at the calyx of Held synapse of rat pups2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Developmental increase in hyperpolarization-activated current regulates intrinsic firing properties in rat vestibular ganglion cells.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] キンギョ網膜双極細胞終末端におけるシナプスリボン近位および遠位からのグルタミン酸放出の可視化2023

Author(s)

Organizer

Data Source

[Presentation] Spatiotemporal dynamics of glutamate release from individual ribbon and non-ribbon regions in the goldfish retinal bipolar cell terminal.2023

Author(s)

Organizer

Data Source

[Presentation] Probing glutamate release sites at the ribbon-type synapses in the goldfish retinal bipolar cell terminal2022

Author(s)

Organizer

Data Source

[Presentation] キンギョ網膜双極細胞リボンシナプスにおけるグルタミン酸イメージング2021

Author(s)

Takago Hideki 鷹合秀輝

鷹合秀輝タカゴウヒデキ