takamatsu hiroyuki 高松博幸

… Alternative Names

TAKAMATSU Hiroyuki 高松博幸

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Researcher Number	70401932
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 融合科学系, 教授
Affiliation (based on the past Project Information) *help	2025: 金沢大学, 融合科学系, 教授 2022 – 2023: 金沢大学, 融合科学系, 教授 2021: 金沢大学, 融合科学系, 講師 2017 – 2020: 金沢大学, 医学系, 講師 2014 – 2016: 金沢大学, 医学系, 助教 … More 2011: 金沢大学, 医学系, 助教 2008 – 2010: 金沢大学, 医学系, 協力研究員 2007: 金沢大学, 医学系研究科, 協カ研究員 2007: 金沢大学, 医学系研究科, 協力研究員 2007: 金沢大学, 医学部附属病院, 協力研究員 2006: 金沢大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Laboratory medicine / Hematology Except Principal Investigator Hematology
Keywords	Principal Investigator 微小残存病変 / HLA抗原 / モノクローナル抗体 / HLA / 癌精巣抗原 / 多発性骨髄腫 / 自己抗体 / HLA-DP / 細胞マイクロアレイ / CAR-T … More / B細胞 / 血液腫瘍 / リンパ系腫瘍 / 再生不良性貧血 / 造血器腫瘍 / リアルタイムPCR / ディジタルPCR / マルチパラメーターフローサイトメトリー / 次世代シークエンサー / ハイブリドーマ / 骨髄不全 / モエシン / ポリクローナル抗体 / ノックアウトマウス … More Except Principal Investigator 再生不良性貧血 / 免疫抑制療法 / CD109 / 細胞傷害性T細胞 / 6pUPD / モエシン / 自己抗体 / 抗モエシン抗体 / PNH型血球 / 可溶性HLAペプチドーム / エスケープ造血 / HLA-Aアレル欠失血球 / HLA-B*40:02 / SLIT1 / ゲノム変異 / クローン性造血 / 片親性二倍体 / クロナリティ / RB遺伝子 / 13q- / GPI-アンカー膜蛋白 / 骨髄不全 / TGF-β / PNH / GPIアンカー膜蛋白 / 自己抗原 / HLA / FcRγ / TNF-α / シグナル伝達 / 肝炎後再生不良性貧血 / 抗HSP72抗体 / 2 / ERK1 / 慢性関節リウマチ / moesin / DRS-1 / hnRNPK / P同型血球 / 抗体モエシン抗体 / 抗DRS-1抗体 Less

iPS/ES細胞由来T細胞を用いた新規抗HLAーDP CAR-T細胞療法の開発Principal Investigator
- Principal Investigator
  
  高松博幸
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Development of novel anti-HLA monoclonal antibodies and CAR-T therapy using B cells derived from donorsPrincipal Investigator
- Principal Investigator
  
  高松博幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Production of monoclonal antibodies using B cells derived from patients and their clinical applicationPrincipal Investigator
- Principal Investigator
  
  Takamatsu Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kanazawa University
Development of novel treatments of myeloma based on MRD using next-generation sequencing and protein-array assayPrincipal Investigator
- Principal Investigator
  
  Takamatsu Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kanazawa University
Identification of myelosuppressive cytokines taking advantage of genomic abnormalities of leukocytes in patients with aplastic anemia
- Principal Investigator
  
  NAKAO Shinji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure
- Principal Investigator
  
  NAKAO Shinji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Generation of bone marrow failure model mice by autoantibodies inducing cytokine productionPrincipal Investigator
- Principal Investigator
  
  TAKAMATSU Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Identification of novel auto-antibodies and corresponding antigens in patients with aplastic anemia using CLIP replacement Ii chain library
- Principal Investigator
  
  NAKAO Shinji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
自己抗体による免疫担当細胞からのサイトカイン分泌増強を介した骨髄不全病態の解析
- Principal Investigator
  
  中尾眞二
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University
Establishment of a method to predict the effects of immunosuppressive therapy for aplastic anemia
- Principal Investigator
  
  YAMAZAKI Hirohito
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa University

All 2021 2020 2017 2016 2015 2014 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] ASO-PCR ～ mCRの指標として、「多発性骨髄腫Updating 第8巻多発性骨髄腫の新・診断基準 SMMとMRD Update（清水一之編集）2016
- Author(s)
  高松博幸、清水一之ほか
- Total Pages
  183
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] 多発性骨髄腫における微小残存病変 minimal residual disease (MRD)、「多発性骨髄腫の診療指針（第４版）」、日本骨髄腫学会[編]2016
- Author(s)
  高松博幸、名倉英一ほか
- Total Pages
  152
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] 微小残存病変 (MRD) 測定法、「多発性骨髄腫診療PROGRESS (赤司浩一監修)2016
- Author(s)
  高松博幸、赤司浩一ほか
- Total Pages
  100
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] 微小残存病変解析-手法と造血器腫瘍診療への応用、「造血器腫瘍アトラス（改訂第5版）」2016
- Author(s)
  高松博幸、谷脇雅史ほか
- Total Pages
  863
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] 「白血病学（上）」、日本臨床増刊号2016
- Author(s)
  高松博幸、谷脇雅史ほか
- Total Pages
  539
- Publisher
  次世代シークエンサー (NGS)によるMRD検出
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] 免疫調節薬 IMiDS 基礎と臨床2015
- Author(s)
  高松博幸
- Total Pages
  233
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K08644
[Book] ブラッシュアップ多発性骨髄腫2015
- Author(s)
  高松博幸
- Total Pages
  244
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic　anemia.2021
- Author(s)
  Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S.
- Journal Title
  
  Blood
  
  Volume: － Issue: 25 Pages: 3576-3580
- DOI
  10.1182/blood.2020010586
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18K07293, KAKENHI-PROJECT-18K08318, KAKENHI-PROJECT-19K17823, KAKENHI-PUBLICLY-21H00342
[Journal Article] A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.2020
- Author(s)
  Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Nguyen MAT, Tran DC, Elbadry MIY, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S.
- Journal Title
  
  Haematologica
  
  Volume: － Issue: 6 Pages: 247809-247809
- DOI
  10.3324/haematol.2020.247809
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08707, KAKENHI-PROJECT-20K21705, KAKENHI-PLANNED-16H06502, KAKENHI-PUBLICLY-19H05344, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-18H02689, KAKENHI-PROJECT-19H03686, KAKENHI-PROJECT-18K07293, KAKENHI-PROJECT-19K17823
[Journal Article] Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia2017
- Author(s)
  Yoshitaka Zaimoku*, Hiroyuki Takamatsu*, Kazuyoshi Hosomichi*, Tatsuhiko Ozawa, Noriharu Nakagawa, Tatsuya Imi, Hiroyuki Maruyama, Takamasa Katagiri, Hiroyuki Kishi, Atsushi Tajima, Atsushi Muraguchi, Koichi Kashiwase, and Shinji Nakao , *: contributed equally
- Journal Title
  
  Blood
  
  Volume: 129 Pages: 2908-2916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] A comparison of minimal residual disease detection in autografts among ASO-qPCR, droplet digital PCR, and next-generation sequencing in patients with multiple myeloma who underwent autologous stem cell transplantation.2017
- Author(s)
  Hiroyuki Takamatsu, Rachel K Wee et al.,
- Journal Title
  
  Br J Haematol, in press.
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 次世代シークエンサーと蛋白質アレイを用いた骨髄腫病態解析2017
- Author(s)
  高松博幸
- Journal Title
  
  Bio Clinica
  
  Volume: 32 Pages: 70-74
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 微小残存病変（MRD)測定の臨床的意義 1）アリル特異的PCR (ASO-PCR)と次世代シークエンサーを用いたMRD測定2017
- Author(s)
  高松博幸
- Journal Title
  
  血液フロンティア
  
  Volume: 27 Pages: 49-55
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Abnormal heavy/light chain ratio after treatment is associated with shorter survival in patients with IgA myeloma.2017
- Author(s)
  Suehara Y, Takamatsu H, Fukumoto K, Fujisawa M, Narita K, Usui Y, Takeuchi M, Endean K, Matsue K
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 2 Pages: 187-192
- DOI
  10.1111/cas.13125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Prognostic value of sequencing-based minimal residual disease detection in patients with multiple myeloma who underwent autologous stem cell transplantation.2017
- Author(s)
  Hiroyuki Takamatsu, Naoki Takezako et al.,
- Journal Title
  
  Ann Oncol
  
  Volume: 28 Pages: 2503-2510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Comparison of minimal residual disease detection by multiparameter flow cytometry, ASO-qPCR, droplet digital PCR, and deep sequencing in patients with multiple myeloma who underwent autologous stem cell transplantation.2017
- Author(s)
  Hiroyuki Takamatsu
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 6 Pages: 91-101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 診断と治療効果判定に必要な新たな検査法2017
- Author(s)
  高松博幸
- Journal Title
  
  Vita
  
  Volume: 34 Pages: 54-61
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Epstein-Barr virus-associated leukemic lymphoma after allogeneic stem cell transplantation.2016
- Author(s)
  Takamatsu H, Araki R, Nishimura R, Yachie A, Espinoza JL, Okumura H, Yoshida T, Kuzushima K, Nakao S
- Journal Title
  
  J Clin Virol
  
  Volume: 80 Pages: 82-86
- DOI
  10.1016/j.jcv.2016.04.020
- NAID
  120005771106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14F04419, KAKENHI-PROJECT-15K08644
[Journal Article] 微小残存病変評価方法と臨床的意義2016
- Author(s)
  高松　博幸
- Journal Title
  
  Pharma Medica
  
  Volume: 34 Pages: 59-63
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 効果判定と微小残存病変. 微小残存病変　次世代シークエンサーによる微小残存病変評価、多発性骨髄腫学-最新の診療と基礎研究2016
- Author(s)
  高松　博幸
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 565-569
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 造血器腫瘍における微小残存病変解析法とその臨床的意義2015
- Author(s)
  高松　博幸
- Journal Title
  
  金沢大学十全医学会雑誌
  
  Volume: 124 Pages: 92-96
- NAID
  120005703048
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Cord Blood Transplantation for Multiple Myeloma: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation2015
- Author(s)
  Kawamura K, Takamatsu H, Ikeda T, Komatsu T, Aotsuka N, Amano I, Yamamoto G, Watanabe K, Ohno Y, Matsue K, Kouzai Y, Tsukada N, Ishiyama K, Anzai N, Kato K, Suzuki R, Sunami K, Kanda Y
- Journal Title
  
  Biol Blood Marrow Transplant
  
  Volume: 21 Issue: 7 Pages: 1291-1298
- DOI
  10.1016/j.bbmt.2015.02.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Changing trends in prognostic factors for patients with multiple myeloma after autologous stem cell transplantation during the immunomodulator drug/proteasome inhibitor era2015
- Author(s)
  Hiroyuki Takamatsu, Sumihisa Honda, Toshihiro Miyamoto, Kenji Yokoyama, Shotaro Hagiwara, Toshiro Ito, Naoto Tomita, Shinsuke Iida, Toshihiro Iwasaki, Hisashi Sakamaki, Ritsuro Suzuki, Kazutaka Sunami.
- Journal Title
  
  Cancer Science
  
  Volume: 106 Issue: 2 Pages: 179-185
- DOI
  10.1111/cas.12594
- NAID
  120005668382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 多発性骨髄腫の微小残存病変と治療モニタリング2015
- Author(s)
  高松博幸
- Journal Title
  
  血液内科
  
  Volume: 70 Pages: 698-703
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Prognostic significance of sequencing-based MRD detection in multiple myeloma2015
- Author(s)
  高松　博幸
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 56 Issue: 8 Pages: 989-996
- DOI
  10.11406/rinketsu.56.989
- NAID
  130005096287
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] 骨髄腫患者の経過観察中に必要な検査、特集：外来で診るリンパ腫・骨髄腫2015
- Author(s)
  高松博幸
- Journal Title
  
  medicina
  
  Volume: 52 Pages: 2156-2160
- Data Source
  KAKENHI-PROJECT-15K08644
[Journal Article] Successful hyperbaric oxygen therapy for refractory BK virus-associated hemorrhagic cystitis after cord blood transplantation.2014
- Author(s)
  Hosokawa K, Yamazaki H, Nakamura T, Yoroidaka T, Imi T, Shima Y, Ohata K, Takamatsu H, Kotani T, Kondo Y, Takami A, Nakao S.
- Journal Title
  
  Transp Infectious Dis
  
  Volume: 16 Issue: 5 Pages: 843-846
- DOI
  10.1111/tid.12266
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14F04419, KAKENHI-PROJECT-24390243, KAKENHI-PROJECT-24591418, KAKENHI-PROJECT-25670448
[Journal Article] Aplastic anemia successfully treated with rituximab : the possible role of aplastic anemia-associated autoantibodies as a marker for response2011
- Author(s)
  Takamatsu, H., Yagasaki, H., Takahashi, Y., Hama, A., Saikawa, Y., Yachie, A., Koizumi, S., Kojima, S. & Nakao, S
- Journal Title
  
  Eur J Haematol
  
  Volume: 86 Pages: 541-545
- NAID
  120003141908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] Aplastic anemia successfully treated with rituximab : the possible role of aplastic anemia-associated autoantibodies as a marker for response2011
- Author(s)
  Takamatsu.H, Nakao.S, et.al.
- Journal Title
  
  European Journal of Haematology
  
  Volume: in press
- NAID
  120003141908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] Aplastic anemia successfully treated with rituximab : The possible role of aplastic anemia-associated autoantibodies as a marker for response2011
- Author(s)
  Takamatsu, H., Yagasaki, H., Takahashi, Y., Hama, A., Saikawa, Y., Yachie, A., Koizumi, S., Kojima, S., Nakao, S.
- Journal Title
  
  Eur J Haematol
  
  Volume: 86 Pages: 541-5
- NAID
  120003141908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Aplastic anemia successfully treated with rituximab : the possible role of aplastic anemia-associated autoantibodies as a marker for response2011
- Author(s)
  Takamatsu, H., Yagasaki, H., Takahashi, Y., Hama, A., Saikawa, Y., Yachie, A., Koizumi, S., Kojima, S., N akao, S.
- Journal Title
  
  Eur J Haematol
  
  Volume: 86 Pages: 541-545
- NAID
  120003141908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Aplastic anemia successfully treated with rituximab : The possible role of aplastic anemia-associated autoantibodies as a marker for response.2010
- Author(s)
  Takamatsu H, Yagasaki H, Taka hashi Y, et al.
- Journal Title
  
  Eur J Haematol
  
  Volume: (In press)
- NAID
  120003141908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] 骨髄不全における免疫病態の診断:自己抗体検出の意義2010
- Author(s)
  高松博幸, 中尾眞二
- Journal Title
  
  臨床血液
  
  Volume: Vol.51, No.8 Pages: 654-663
- NAID
  130004501439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] Autoantibodies specific to hnRNP K : a new diagnostic marker forimmune pathophysiology in aplastic anemia2010
- Author(s)
  Qi Z, Takamatsu H, Espinoza JL, Lu X, Sugimori N, Yamazaki H, Okawa K, Nakao S
- Journal Title
  
  Ann Hematol
  
  Volume: 89(12) Pages: 1255-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] Autoantibodies specific to hnRNP K : a new diagnostic marker for immune pathophysiology in aplastic anemia2010
- Author(s)
  Qi, Z., Takamatsu, H., Espinoza, J, L., Lu, X., Sugimori, N., Yamazaki, H., Okawa, K., Nakao, S.
- Journal Title
  
  Ann Hematol
  
  Volume: 89 Pages: 1255-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] 骨髄不全における免疫病態の誇断:自己抗体槍出の意義2010
- Author(s)
  高松博幸、中尾眞二
- Journal Title
  
  臨床血液
  
  Volume: 51 Pages: 654-663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] Autoantibodies specific to hnRNP K : a new diagnostic marker for immune pathophysiology in aplastic anemia.2010
- Author(s)
  Qi Z, Takamatsu H, Esninoza JL, et al.
- Journal Title
  
  Ann Hematol
  
  Volume: 89 Pages: 1255-1263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma.2009
- Author(s)
  Takamatsu H, et al
- Journal Title
  
  J Immunol 182
  
  Pages: 703-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659243
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma2009
- Author(s)
  Takamatsu H, Espinoza JL, Lu X, Qi Z, Okawa K, Nakao S
- Journal Title
  
  J Immunol 182
  
  Pages: 703-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390260
[Journal Article] Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway2009
- Author(s)
  Espinoza, J, L., Takamatsu, H., Lu, X., Qi, Z., Nakao, S.
- Journal Title
  
  Int Immunol
  
  Volume: 21 Pages: 913-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TN F-alpha and IFN-gamma.2009
- Author(s)
  Takamatsu H, Espinoza JL, Lu X, Qi Z, Okawa K, Nakao S
- Journal Title
  
  J Immunol 182
  
  Pages: 703-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-alpha through an ERK1/2-dependent pathway.2009
- Author(s)
  Espinoza JL, Takamatsu H, Lu X, Qi Z, Nakao S
- Journal Title
  
  Int Immunol 21
  
  Pages: 913-923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma2009
- Author(s)
  Takamatsu H, et al
- Journal Title
  
  J Immunol 182
  
  Pages: 703-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390260
[Journal Article] Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma2009
- Author(s)
  Takamatsu, H., Espinoza, J, L., Lu, X., Qi, Z., Okawa, K., Nakao, S.
- Journal Title
  
  J Immunol
  
  Volume: 182 Pages: 703-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390291
[Journal Article] Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-αthrough an ERK1/2 dependent pathway2009
- Author(s)
  J. Luis Espinoza, Hiroyuki Takamatsu, Xuzhang Lu, Zhirong Qi and Shinji Nakao
- Journal Title
  
  Int Immunol
  
  Volume: 21(8) Pages: 913-23
- NAID
  10025387602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591237
[Journal Article] A marked increase in myeloblasts in the peripheral blood of a patient with Burkitt lymphoma following G-CSF administration2008
- Author(s)
  Takamatsu H, Yamazaki H, Nakao S., (6人・(3)番目)
- Journal Title
  
  Acta Haematologica 120
  
  Pages: 174-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591050
[Journal Article] Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia.2007
- Author(s)
  Hiroyuki Takamatsu
- Journal Title
  
  Blood 109・6
  
  Pages: 2514-2520
- Data Source
  KAKENHI-PROJECT-18591050
[Presentation] Comparison of MRD detection in autografts of multiple myeloma patients between EuroFlow and NGS.2017
- Author(s)
  Hiroyuki Takamatsu，Naoki Takezako, Rachel Wee, Takeshi Yoroidaka, Takeshi Yamashita, Ryoichi Murata, Jianbiao Zheng, Martin Moorhead, Victoria Carlton, Malek Faham, Shinji Nakao.
- Organizer
  日本血液学会一般口演（英語セッション）
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] 多発性骨髄腫微小残存病変評価法の比較：OneFlow/DuraClone-MFC, EuroFlow, 及びNGS2017
- Author(s)
  高松博幸、鎧高健志、坂本淳、平郡雄二、野間芳弘、石田禎夫、鈴木憲史、中尾眞二、村上博和、Brian Durie、清水一之
- Organizer
  日本骨髄腫学会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] Implementation of MRD Testing in MM in Asia2017
- Author(s)
  Hiroyuki Takamatsu
- Organizer
  国際骨髄腫財団Asian Myeloma Network Summit 2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] COMPARISON BETWEEN 8-COLOR MULTIPARAMETER FLOW CYTOMETRY AND NEXT-GENERATION SEQUENCING TO DETECT MINIMAL RESIDUAL DISEASE IN MULTIPLE MYELOMA PATIENTS WHOUNDERWENT AUTO-SCT2016
- Author(s)
  Hiroyuki Takamatsu, Rachel Wee, Naoki Takezako, Jianbiao Zheng, Victoria Carlton, Martin Moorhead, Takashi　Yoshida, Malek Faham, Shinji Nakao
- Organizer
  21th congress of the European Hematology Association Meeting
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] Prognostic Value of Sequencing-Based Minimal Residual Disease Detection in Patients with Multiple Myeloma Who Underwent Autologous Stem Cell Transplantation2015
- Author(s)
  Hiroyuki Takamatsu, Ryoichi Murata, Jianbiao Zheng, Martin Moorhead, Naoki Takezako, Shigeki Ito,Toshihiro Miyamoto, Kenji Yokoyama, Kosei Matsue, Tsutomu Sato, Toshiro Kurokawa, Hideo Yagi, Yasushi Terasaki, Kinya Ohata, Takashi Yoshida, Malek Faham, Shinji Nakao
- Organizer
  米国血液学会
- Place of Presentation
  ORLANDO, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] A Comparison of Minimal Residual Disease Detection Among ASOPCR, Dd-PCR and Deep-Sequencing in Patients with Multiple Myeloma Who Underwent Autologous Stem Cell Transplantation2015
- Author(s)
  Rachel K Wee, Hiroyuki Takamatsu, Ryoichi Murata, Jianbiao Zheng, Martin Moorhead, Naoki Takezako, Shigeki Ito, Toshihiro Miyamoto, Kenji Yokoyama, Kosei Matsue, Tsutomu Sato, Toshiro Kurokawa, Hideo Yagi, Yasushi Terasaki, Kinya Ohata, Takashi Yoshida, Malek Faham and Shinji Nakao
- Organizer
  米国血液学会
- Place of Presentation
  ORLANDO, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] Comparison of MRD detection in MM between multiparameter flow cytometry and deep-sequencing2015
- Author(s)
  HIROYUKI TAKAMATSU, JIANBIAO ZHENG, MARTIN MOORHEAD, MALEK FAHAM, SHINJI NAKAO, KOSEI MATSUE
- Organizer
  日本血液学会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K08644
[Presentation] Evidence that HLA-B*40:02 and HLA-Α*31:01 are strongly involved in the presentation of autoantigens to CTLs responsible for the development of acquired aplastic anemia2014
- Author(s)
  Yoshitaka Zaimoku, Hiroyuki Maruyama, Kana Maruyama, Takamasa Katagiri, An T. T. Dao, Hiroyuki Takamatsu, Hirohito Yamazaki, Koichi Kashiwase　and Shinji Nakao
- Organizer
  The American Society of Hematology 56th Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, California, USA.
- Year and Date
  2014-12-07
- Data Source
  KAKENHI-PROJECT-24390243
[Presentation] Role of Moesin in Murine Hematopoiesis2011
- Author(s)
  Hiroyuki Takamatsu, et al
- Organizer
  第53回米国血液学会
- Place of Presentation
  米国・カリフォルニア州サンディエゴSan Diego Convention Center
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] Role of Moesin in Murine Hematopoiesis2011
- Author(s)
  Hiroyuki Takamatsu, Shinji Nakao et al.
- Organizer
  第53回米国血液学会
- Place of Presentation
  San Diego Convention Center,(USA)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] 骨髄不全における免疫病態の診断 : 自己抗体検出の意義2009
- Author(s)
  高松博幸, 中尾眞二
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都会館 (京都府)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] Identification of a Novel Auto-Antibody Highly Prevalent in Patients with Hepatitis-Associated and Idiopathic Aplastic Anemia2009
- Author(s)
  Hiroyuki Takamatsu, Shinji Nakao, et al.
- Organizer
  第51回米国血液学会
- Place of Presentation
  Ernest N. Morial Convention Center, Hall E, New Orleans, LA, (USA)
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] 骨髄不全における免疫病態の診断:自己抗体検出の意義2009
- Author(s)
  高松博幸、中尾眞二
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都会館(京都府)
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] Identification of a Novel Auto-Antibody Highly Prevalent in Patients with Hepatitis-Associated and Idiopathic Aplastic Anemia2009
- Author(s)
  Hiroyuki Takamatsu, Shinji Nakao et al.
- Organizer
  第51回米国血液学会
- Place of Presentation
  Ernest N. Morial Convention Center,(USA)
- Year and Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] Anti-HSP72 Abs are frequently detectable in serum of hepatitis-associated aplastic anemia pts2009
- Author(s)
  高松博幸, 中尾眞二, ら
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都会館 (京都府)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591237
[Presentation] Anti-HSP72 Abs are frequently detectable in serum of hepatitis-associated aplastic anemia pts2009
- Author(s)
  高松博幸、中尾眞二
- Organizer
  第71回日本血液学会学術集会
- Place of Presentation
  国立京都会館(京都府)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21591237

1. NAKAO Shinji (70217660)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. KONDO Yukio (10322116)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. YAMAZAKI Hirohito (50361994)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. TAKAMI Akiyoshi (80324078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SENJYU Satoru (50274709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISHIYAMA Ken (60377380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AKATSUKA Yoshiki (70333391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MATSUI Hirotaka (60379849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NISHIUCHI Takumi (20334790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NISHIKAWA Hiroyoshi (10444431)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉盛千春 (30422645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中尾真二

# of Collaborated Projects: 0 results

# of Collaborated Products: 24 results
13. 片桐孝和

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 細川晃平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

takamatsu hiroyuki 高松 博幸

TAKAMATSU Hiroyuki 高松 博幸

Research Projects

Research Products

Co-Researchers

iPS/ES細胞由来T細胞を用いた新規抗HLAーDP CAR-T細胞療法の開発Principal Investigator

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Development of novel anti-HLA monoclonal antibodies and CAR-T therapy using B cells derived from donorsPrincipal Investigator

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Production of monoclonal antibodies using B cells derived from patients and their clinical applicationPrincipal Investigator

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Development of novel treatments of myeloma based on MRD using next-generation sequencing and protein-array assayPrincipal Investigator

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Identification of myelosuppressive cytokines taking advantage of genomic abnormalities of leukocytes in patients with aplastic anemia

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Identification of auto-antigens which trigger the development of immune-mediated bone marrow failure

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Generation of bone marrow failure model mice by autoantibodies inducing cytokine productionPrincipal Investigator

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Identification of novel auto-antibodies and corresponding antigens in patients with aplastic anemia using CLIP replacement Ii chain library

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自己抗体による免疫担当細胞からのサイトカイン分泌増強を介した骨髄不全病態の解析

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Establishment of a method to predict the effects of immunosuppressive therapy for aplastic anemia

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[Book] ASO-PCR ～ mCRの指標として、「多発性骨髄腫Updating 第8巻 多発性骨髄腫の新・診断基準 SMMとMRD Update（清水一之編集）2016

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[Book] 多発性骨髄腫における微小残存病変 minimal residual disease (MRD)、「多発性骨髄腫の診療指針（第４版）」、日本骨髄腫学会[編]2016

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[Book] 微小残存病変 (MRD) 測定法、「多発性骨髄腫診療PROGRESS (赤司浩一 監修)2016

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Total Pages

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takamatsu hiroyuki 高松博幸

TAKAMATSU Hiroyuki 高松博幸

[Book] ASO-PCR ～ mCRの指標として、「多発性骨髄腫Updating 第8巻多発性骨髄腫の新・診断基準 SMMとMRD Update（清水一之編集）2016

[Book] 微小残存病変 (MRD) 測定法、「多発性骨髄腫診療PROGRESS (赤司浩一監修)2016

[Journal Article] HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic　anemia.2021